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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RHOD-PFDN4 (FusionGDB2 ID:73504)

Fusion Gene Summary for RHOD-PFDN4

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOD-PFDN4
Fusion gene ID: 73504
HgeneTgene
Gene symbol

RHOD

PFDN4

Gene ID

29984

5203

Gene nameras homolog family member Dprefoldin subunit 4
SynonymsARHD|RHOHP1|RHOM|RhoC1|PFD4
Cytomap

11q13.2

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho-related GTP-binding protein RhoDRho-related protein HP1ras homolog Dras homolog gene family, member Aras homolog gene family, member Dprefoldin subunit 4prefoldin 4protein C-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000308831, ENST00000533360, 
ENST00000532559, 		ENST00000371419, 
ENST00000487129, 
Fusion gene scores* DoF score1 X 2 X 1=27 X 6 X 5=210
# samples 29
** MAII scorelog2(2/2*10)=3.32192809488736log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RHOD [Title/Abstract] AND PFDN4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRHOD(66834318)-PFDN4(52830890), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RHOD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PFDN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01ARHODchr11

66834318

+PFDN4chr20

52830890

+
ChimerDB4BRCATCGA-A1-A0SNRHODchr11

66824505

+PFDN4chr20

52830889

+
ChimerDB4BRCATCGA-A1-A0SN-01ARHODchr11

66834318

+PFDN4chr20

52830890

+
ChimerDB4BRCATCGA-A1-A0SN-01ARHODchr11

66824505

+PFDN4chr20

52830890

+


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Fusion Gene ORF analysis for RHOD-PFDN4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000308831ENST00000371419RHODchr11

66834318

+PFDN4chr20

52830890

+
5CDS-3UTRENST00000308831ENST00000487129RHODchr11

66834318

+PFDN4chr20

52830890

+
In-frameENST00000533360ENST00000371419RHODchr11

66834318

+PFDN4chr20

52830890

+
5CDS-3UTRENST00000533360ENST00000487129RHODchr11

66834318

+PFDN4chr20

52830890

+
intron-3CDSENST00000532559ENST00000371419RHODchr11

66834318

+PFDN4chr20

52830890

+
intron-3UTRENST00000532559ENST00000487129RHODchr11

66834318

+PFDN4chr20

52830890

+
In-frameENST00000308831ENST00000371419RHODchr11

66824505

+PFDN4chr20

52830889

+
5CDS-3UTRENST00000308831ENST00000487129RHODchr11

66824505

+PFDN4chr20

52830889

+
In-frameENST00000533360ENST00000371419RHODchr11

66824505

+PFDN4chr20

52830889

+
5CDS-3UTRENST00000533360ENST00000487129RHODchr11

66824505

+PFDN4chr20

52830889

+
In-frameENST00000532559ENST00000371419RHODchr11

66824505

+PFDN4chr20

52830889

+
5CDS-3UTRENST00000532559ENST00000487129RHODchr11

66824505

+PFDN4chr20

52830889

+
In-frameENST00000308831ENST00000371419RHODchr11

66824505

+PFDN4chr20

52830890

+
5CDS-3UTRENST00000308831ENST00000487129RHODchr11

66824505

+PFDN4chr20

52830890

+
In-frameENST00000533360ENST00000371419RHODchr11

66824505

+PFDN4chr20

52830890

+
5CDS-3UTRENST00000533360ENST00000487129RHODchr11

66824505

+PFDN4chr20

52830890

+
In-frameENST00000532559ENST00000371419RHODchr11

66824505

+PFDN4chr20

52830890

+
5CDS-3UTRENST00000532559ENST00000487129RHODchr11

66824505

+PFDN4chr20

52830890

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308831RHODchr1166834318+ENST00000371419PFDN4chr2052830890+15994154795263
ENST00000533360RHODchr1166834318+ENST00000371419PFDN4chr2052830890+155737343753236
ENST00000308831RHODchr1166824505+ENST00000371419PFDN4chr2052830889+14012174597197
ENST00000533360RHODchr1166824505+ENST00000371419PFDN4chr2052830889+135917543555170
ENST00000532559RHODchr1166824505+ENST00000371419PFDN4chr2052830889+133014614526170
ENST00000308831RHODchr1166824505+ENST00000371419PFDN4chr2052830890+14012174597197
ENST00000533360RHODchr1166824505+ENST00000371419PFDN4chr2052830890+135917543555170
ENST00000532559RHODchr1166824505+ENST00000371419PFDN4chr2052830890+133014614526170

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308831ENST00000371419RHODchr1166834318+PFDN4chr2052830890+0.0002141360.99978584
ENST00000533360ENST00000371419RHODchr1166834318+PFDN4chr2052830890+0.0002143170.9997857
ENST00000308831ENST00000371419RHODchr1166824505+PFDN4chr2052830889+0.0002276340.99977237
ENST00000533360ENST00000371419RHODchr1166824505+PFDN4chr2052830889+0.000264420.99973553
ENST00000532559ENST00000371419RHODchr1166824505+PFDN4chr2052830889+0.0002494260.99975055
ENST00000308831ENST00000371419RHODchr1166824505+PFDN4chr2052830890+0.0002276340.99977237
ENST00000533360ENST00000371419RHODchr1166824505+PFDN4chr2052830890+0.000264420.99973553
ENST00000532559ENST00000371419RHODchr1166824505+PFDN4chr2052830890+0.0002494260.99975055

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Fusion Genomic Features for RHOD-PFDN4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RHODchr1166834318+PFDN4chr2052830889+4.46E-081
RHODchr1166824505+PFDN4chr2052830889+1.06E-081
RHODchr1166824505+PFDN4chr2052830889+1.06E-081
RHODchr1166834318+PFDN4chr2052830889+4.46E-081
RHODchr1166824505+PFDN4chr2052830889+1.06E-081
RHODchr1166824505+PFDN4chr2052830889+1.06E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RHOD-PFDN4


check button Go to

FGviewer for the breakpoints of chr11:66834318-chr20:52830890

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHODchr11:66834318chr20:52830890ENST00000308831+3546_54110.0211.0MotifEffector region
HgeneRHODchr11:66824505chr20:52830889ENST00000308831+1524_3144.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66824505chr20:52830890ENST00000308831+1524_3144.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66834318chr20:52830890ENST00000308831+3524_31110.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66834318chr20:52830890ENST00000308831+3571_75110.0211.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHODchr11:66824505chr20:52830889ENST00000308831+1546_5444.0211.0MotifEffector region
HgeneRHODchr11:66824505chr20:52830890ENST00000308831+1546_5444.0211.0MotifEffector region
HgeneRHODchr11:66824505chr20:52830889ENST00000308831+15129_13244.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66824505chr20:52830889ENST00000308831+1571_7544.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66824505chr20:52830890ENST00000308831+15129_13244.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66824505chr20:52830890ENST00000308831+1571_7544.0211.0Nucleotide bindingGTP
HgeneRHODchr11:66834318chr20:52830890ENST00000308831+35129_132110.0211.0Nucleotide bindingGTP


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Fusion Gene Sequence for RHOD-PFDN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000308831_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66834318_+_PFDN4_chr20_52830890_length(transcript)=1599nt_BP=415nt
ATTCCTGCCCCGCCGGGCCTGCCCCGCGCAGTCTGGGTCTCTGCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGAC
GGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTC
GCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGG
CAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCT
GCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATCA
ACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACCT
AGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTCA
AGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGCG
AGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATAC
TTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTAA
AAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTATG
TATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTTA
GAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGGG
GAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATATA
TTTTATTTAAATATATGTTACATATTATATTTAAACATACATATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAAG
AATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATGT
GCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGAT

>In-frame_ENST00000308831_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66834318_+_PFDN4_chr20_52830890_length(amino acids)=263AA_start in transcript=4_stop in transcript=795
MPRRACPAQSGSLRRSRPPARSAPGPGMTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGK
PVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLE

--------------------------------------------------------------
>In-frame_ENST00000533360_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66834318_+_PFDN4_chr20_52830890_length(transcript)=1557nt_BP=373nt
GCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCG
GTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGAGCTA
CACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGA
TGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAA
CATCTTTAACCGGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATCAACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCAC
AGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACCTAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTG
CTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTCAAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTT
GCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGCGAGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGG
GAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATACTTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGA
TAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTAAAAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATG
TCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTATGTATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTC
ATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTTAGAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAG
TTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGGGGAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTA
TTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATATATTTTATTTAAATATATGTTACATATTATATTTAAACATACAT
ATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAAGAATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTAT
ACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATGTGCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGA
TTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGATGTGGAAGTTAAACAGCTATGTATGTAAAAGTAAGGCTTATTT

>In-frame_ENST00000533360_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66834318_+_PFDN4_chr20_52830890_length(amino acids)=236AA_start in transcript=43_stop in transcript=753
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDAS
VLLLCFDVTSPNSFDNIFNRAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISH

--------------------------------------------------------------
>In-frame_ENST00000308831_ENST00000371419_TCGA-A1-A0SN_RHOD_chr11_66824505_+_PFDN4_chr20_52830889_length(transcript)=1401nt_BP=217nt
ATTCCTGCCCCGCCGGGCCTGCCCCGCGCAGTCTGGGTCTCTGCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGAC
GGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTC
GCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATCAACAAAAGATAAACAAATT
TGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACCTAGAAGATGCTTGTGATGA
CATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTCAAGAAGAAACGCAAGAAAT
GTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGCGAGTGTTAGCAGATTTGAA
AGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATACTTTTTTTATTTGTTTAAT
AAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTAAAAATTTTCATTTATTTAA
TGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTATGTATTTTGCATAACGATTA
TATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTTAGAATATTTGTTGTTGCAA
TTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGGGGAAAGCACGATGAAAAGA
TGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATATATTTTATTTAAATATATGT
TACATATTATATTTAAACATACATATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAAGAATGGGTAATGTTTAAAC
ATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATGTGCAGAAAGAAATGTTTAG
TGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGATGTGGAAGTTAAACAGCTA

>In-frame_ENST00000308831_ENST00000371419_TCGA-A1-A0SN_RHOD_chr11_66824505_+_PFDN4_chr20_52830889_length(amino acids)=197AA_start in transcript=4_stop in transcript=597
MPRRACPAQSGSLRRSRPPARSAPGPGMTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPEAAEDVNVTFEDQQKINKFA
RNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKV

--------------------------------------------------------------
>In-frame_ENST00000533360_ENST00000371419_TCGA-A1-A0SN_RHOD_chr11_66824505_+_PFDN4_chr20_52830889_length(transcript)=1359nt_BP=175nt
GCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCG
GTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGGCTGC
AGAAGATGTCAATGTTACTTTCGAAGATCAACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAAT
AGAAGTAAAAAAGAAACAACTCCAAAACCTAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCA
AATTGGTGATGTCTTCATTAGCCATTCTCAAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGC
CTTAGAATCCAGAGTGGAATCAATTCAGCGAGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGA
AGCTGATGAAAGTTAAACATTTTATAATACTTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAA
TGACATGGAAAGCAAAACTTTCTTTTTTAAAAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTAT
ATTTTTAAAAGAAGACAGTATTCACCTATGTATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTT
AAGCAATCTTTTATGTTTCTATATTATTTAGAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCT
GTCTGATTTTAATTGCTGTCTAATGACGGGGAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTT
GTCATAGACTTCAAAATATATATGTATATATTTTATTTAAATATATGTTACATATTATATTTAAACATACATATTTAACATTTTTTACAT
ATCTATCAATATCAGAGATTTGGGTAAAAGAATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCA
CAGAAGAACGTTTTAGAAACCAAGAGATGTGCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTG
TAATTAATTGGGGTTTATATTGATAAAGATGTGGAAGTTAAACAGCTATGTATGTAAAAGTAAGGCTTATTTCTTAAATAAAGGATGCAT

>In-frame_ENST00000533360_ENST00000371419_TCGA-A1-A0SN_RHOD_chr11_66824505_+_PFDN4_chr20_52830889_length(amino acids)=170AA_start in transcript=43_stop in transcript=555
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPEAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDAC

--------------------------------------------------------------
>In-frame_ENST00000532559_ENST00000371419_TCGA-A1-A0SN_RHOD_chr11_66824505_+_PFDN4_chr20_52830889_length(transcript)=1330nt_BP=146nt
CGCCCGGCCCCGGGATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACG
GCGGCTGCGGGAAGACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATC
AACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACC
TAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTC
AAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGC
GAGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATA
CTTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTA
AAAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTAT
GTATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTT
AGAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGG
GGAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATAT
ATTTTATTTAAATATATGTTACATATTATATTTAAACATACATATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAA
GAATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATG
TGCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGA

>In-frame_ENST00000532559_ENST00000371419_TCGA-A1-A0SN_RHOD_chr11_66824505_+_PFDN4_chr20_52830889_length(amino acids)=170AA_start in transcript=14_stop in transcript=526
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPEAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDAC

--------------------------------------------------------------
>In-frame_ENST00000308831_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66824505_+_PFDN4_chr20_52830890_length(transcript)=1401nt_BP=217nt
ATTCCTGCCCCGCCGGGCCTGCCCCGCGCAGTCTGGGTCTCTGCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGAC
GGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTC
GCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATCAACAAAAGATAAACAAATT
TGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACCTAGAAGATGCTTGTGATGA
CATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTCAAGAAGAAACGCAAGAAAT
GTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGCGAGTGTTAGCAGATTTGAA
AGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATACTTTTTTTATTTGTTTAAT
AAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTAAAAATTTTCATTTATTTAA
TGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTATGTATTTTGCATAACGATTA
TATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTTAGAATATTTGTTGTTGCAA
TTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGGGGAAAGCACGATGAAAAGA
TGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATATATTTTATTTAAATATATGT
TACATATTATATTTAAACATACATATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAAGAATGGGTAATGTTTAAAC
ATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATGTGCAGAAAGAAATGTTTAG
TGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGATGTGGAAGTTAAACAGCTA

>In-frame_ENST00000308831_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66824505_+_PFDN4_chr20_52830890_length(amino acids)=197AA_start in transcript=4_stop in transcript=597
MPRRACPAQSGSLRRSRPPARSAPGPGMTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPEAAEDVNVTFEDQQKINKFA
RNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKV

--------------------------------------------------------------
>In-frame_ENST00000533360_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66824505_+_PFDN4_chr20_52830890_length(transcript)=1359nt_BP=175nt
GCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCG
GTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGGCTGC
AGAAGATGTCAATGTTACTTTCGAAGATCAACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAAT
AGAAGTAAAAAAGAAACAACTCCAAAACCTAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCA
AATTGGTGATGTCTTCATTAGCCATTCTCAAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGC
CTTAGAATCCAGAGTGGAATCAATTCAGCGAGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGA
AGCTGATGAAAGTTAAACATTTTATAATACTTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAA
TGACATGGAAAGCAAAACTTTCTTTTTTAAAAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTAT
ATTTTTAAAAGAAGACAGTATTCACCTATGTATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTT
AAGCAATCTTTTATGTTTCTATATTATTTAGAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCT
GTCTGATTTTAATTGCTGTCTAATGACGGGGAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTT
GTCATAGACTTCAAAATATATATGTATATATTTTATTTAAATATATGTTACATATTATATTTAAACATACATATTTAACATTTTTTACAT
ATCTATCAATATCAGAGATTTGGGTAAAAGAATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCA
CAGAAGAACGTTTTAGAAACCAAGAGATGTGCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTG
TAATTAATTGGGGTTTATATTGATAAAGATGTGGAAGTTAAACAGCTATGTATGTAAAAGTAAGGCTTATTTCTTAAATAAAGGATGCAT

>In-frame_ENST00000533360_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66824505_+_PFDN4_chr20_52830890_length(amino acids)=170AA_start in transcript=43_stop in transcript=555
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPEAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDAC

--------------------------------------------------------------
>In-frame_ENST00000532559_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66824505_+_PFDN4_chr20_52830890_length(transcript)=1330nt_BP=146nt
CGCCCGGCCCCGGGATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACG
GCGGCTGCGGGAAGACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATC
AACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACC
TAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTC
AAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGC
GAGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATA
CTTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTA
AAAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTAT
GTATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTT
AGAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGG
GGAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATAT
ATTTTATTTAAATATATGTTACATATTATATTTAAACATACATATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAA
GAATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATG
TGCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGA

>In-frame_ENST00000532559_ENST00000371419_TCGA-A1-A0SN-01A_RHOD_chr11_66824505_+_PFDN4_chr20_52830890_length(amino acids)=170AA_start in transcript=14_stop in transcript=526
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPEAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDAC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RHOD-PFDN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RHOD-PFDN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RHOD-PFDN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource