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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RHPN2-ZNF677 (FusionGDB2 ID:73570)

Fusion Gene Summary for RHPN2-ZNF677

check button Fusion gene summary
Fusion gene informationFusion gene name: RHPN2-ZNF677
Fusion gene ID: 73570
HgeneTgene
Gene symbol

RHPN2

ZNF677

Gene ID

85415

342926

Gene namerhophilin Rho GTPase binding protein 2zinc finger protein 677
SynonymsP76RBE|RHOBP-
Cytomap

19q13.11

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionrhophilin-276 kDa RhoB effector proteinGTP-Rho-binding protein 2rhophilin-like Rho-GTPase binding proteinzinc finger protein 677hypothetical protein MGC48625
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000254260, ENST00000400226, 
ENST00000588683, 		ENST00000333952, 
ENST00000598513, ENST00000599012, 
ENST00000594681, ENST00000598806, 
ENST00000601828, ENST00000601413, 
ENST00000595293, 
Fusion gene scores* DoF score18 X 12 X 11=23761 X 1 X 1=1
# samples 292
** MAII scorelog2(29/2376*10)=-3.03441003078583
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/1*10)=4.32192809488736
Context

PubMed: RHPN2 [Title/Abstract] AND ZNF677 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRHPN2(33535155)-ZNF677(53747150), # samples:2
Anticipated loss of major functional domain due to fusion event.RHPN2-ZNF677 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RHPN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZNF677 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HD-01ARHPN2chr19

33535155

-ZNF677chr19

53747150

-
ChimerDB4STADTCGA-HU-A4HDRHPN2chr19

33535154

-ZNF677chr19

53747150

-
ChimerDB4STADTCGA-HU-A4HD-01ARHPN2chr19

33535155

-ZNF677chr19

53747150

-


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Fusion Gene ORF analysis for RHPN2-ZNF677

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000254260ENST00000333952RHPN2chr19

33535155

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000598513RHPN2chr19

33535155

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000599012RHPN2chr19

33535155

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000594681RHPN2chr19

33535155

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000598806RHPN2chr19

33535155

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000601828RHPN2chr19

33535155

-ZNF677chr19

53747150

-
In-frameENST00000254260ENST00000601413RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5CDS-intronENST00000254260ENST00000595293RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000333952RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000598513RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000599012RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000594681RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000598806RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000601828RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000601413RHPN2chr19

33535155

-ZNF677chr19

53747150

-
5UTR-intronENST00000400226ENST00000595293RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000333952RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000598513RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000599012RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000594681RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000598806RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000601828RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000601413RHPN2chr19

33535155

-ZNF677chr19

53747150

-
intron-intronENST00000588683ENST00000595293RHPN2chr19

33535155

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000333952RHPN2chr19

33535154

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000598513RHPN2chr19

33535154

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000599012RHPN2chr19

33535154

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000594681RHPN2chr19

33535154

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000598806RHPN2chr19

33535154

-ZNF677chr19

53747150

-
Frame-shiftENST00000254260ENST00000601828RHPN2chr19

33535154

-ZNF677chr19

53747150

-
In-frameENST00000254260ENST00000601413RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5CDS-intronENST00000254260ENST00000595293RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000333952RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000598513RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000599012RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000594681RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000598806RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000601828RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-3CDSENST00000400226ENST00000601413RHPN2chr19

33535154

-ZNF677chr19

53747150

-
5UTR-intronENST00000400226ENST00000595293RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000333952RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000598513RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000599012RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000594681RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000598806RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000601828RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-3CDSENST00000588683ENST00000601413RHPN2chr19

33535154

-ZNF677chr19

53747150

-
intron-intronENST00000588683ENST00000595293RHPN2chr19

33535154

-ZNF677chr19

53747150

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254260RHPN2chr1933535155-ENST00000601413ZNF677chr1953747150-5632212493172
ENST00000254260RHPN2chr1933535154-ENST00000601413ZNF677chr1953747150-5632212493172

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254260ENST00000601413RHPN2chr1933535155-ZNF677chr1953747150-0.248203320.75179666
ENST00000254260ENST00000601413RHPN2chr1933535154-ZNF677chr1953747150-0.248203320.75179666

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Fusion Genomic Features for RHPN2-ZNF677


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RHPN2-ZNF677


check button Go to

FGviewer for the breakpoints of chr19:33535155-chr19:53747150

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF677chr19:33535154chr19:53747150ENST00000333952278_905.03323.3333333333335DomainKRAB
TgeneZNF677chr19:33535154chr19:53747150ENST00000598513258_905.0585.0DomainKRAB
TgeneZNF677chr19:33535155chr19:53747150ENST00000333952278_905.03323.3333333333335DomainKRAB
TgeneZNF677chr19:33535155chr19:53747150ENST00000598513258_905.0585.0DomainKRAB
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227263_2855.03323.3333333333335Zinc fingerC2H2-type 1
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227291_3135.03323.3333333333335Zinc fingerC2H2-type 2
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227319_3415.03323.3333333333335Zinc fingerC2H2-type 3
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227347_3695.03323.3333333333335Zinc fingerC2H2-type 4
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227375_3975.03323.3333333333335Zinc fingerC2H2-type 5
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227403_4255.03323.3333333333335Zinc fingerC2H2-type 6
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227431_4535.03323.3333333333335Zinc fingerC2H2-type 7
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227459_4815.03323.3333333333335Zinc fingerC2H2-type 8
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227487_5095.03323.3333333333335Zinc fingerC2H2-type 9
TgeneZNF677chr19:33535154chr19:53747150ENST0000033395227515_5375.03323.3333333333335Zinc fingerC2H2-type 10
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325263_2855.0585.0Zinc fingerC2H2-type 1
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325291_3135.0585.0Zinc fingerC2H2-type 2
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325319_3415.0585.0Zinc fingerC2H2-type 3
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325347_3695.0585.0Zinc fingerC2H2-type 4
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325375_3975.0585.0Zinc fingerC2H2-type 5
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325403_4255.0585.0Zinc fingerC2H2-type 6
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325431_4535.0585.0Zinc fingerC2H2-type 7
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325459_4815.0585.0Zinc fingerC2H2-type 8
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325487_5095.0585.0Zinc fingerC2H2-type 9
TgeneZNF677chr19:33535154chr19:53747150ENST0000059851325515_5375.0585.0Zinc fingerC2H2-type 10
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227263_2855.03323.3333333333335Zinc fingerC2H2-type 1
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227291_3135.03323.3333333333335Zinc fingerC2H2-type 2
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227319_3415.03323.3333333333335Zinc fingerC2H2-type 3
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227347_3695.03323.3333333333335Zinc fingerC2H2-type 4
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227375_3975.03323.3333333333335Zinc fingerC2H2-type 5
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227403_4255.03323.3333333333335Zinc fingerC2H2-type 6
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227431_4535.03323.3333333333335Zinc fingerC2H2-type 7
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227459_4815.03323.3333333333335Zinc fingerC2H2-type 8
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227487_5095.03323.3333333333335Zinc fingerC2H2-type 9
TgeneZNF677chr19:33535155chr19:53747150ENST0000033395227515_5375.03323.3333333333335Zinc fingerC2H2-type 10
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325263_2855.0585.0Zinc fingerC2H2-type 1
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325291_3135.0585.0Zinc fingerC2H2-type 2
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325319_3415.0585.0Zinc fingerC2H2-type 3
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325347_3695.0585.0Zinc fingerC2H2-type 4
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325375_3975.0585.0Zinc fingerC2H2-type 5
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325403_4255.0585.0Zinc fingerC2H2-type 6
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325431_4535.0585.0Zinc fingerC2H2-type 7
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325459_4815.0585.0Zinc fingerC2H2-type 8
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325487_5095.0585.0Zinc fingerC2H2-type 9
TgeneZNF677chr19:33535155chr19:53747150ENST0000059851325515_5375.0585.0Zinc fingerC2H2-type 10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHPN2chr19:33535154chr19:53747150ENST00000254260-215623_62661.666666666666664687.0Compositional biasNote=Poly-Asp
HgeneRHPN2chr19:33535155chr19:53747150ENST00000254260-215623_62661.666666666666664687.0Compositional biasNote=Poly-Asp
HgeneRHPN2chr19:33535154chr19:53747150ENST00000254260-215111_46061.666666666666664687.0DomainBRO1
HgeneRHPN2chr19:33535154chr19:53747150ENST00000254260-21526_10061.666666666666664687.0DomainREM-1
HgeneRHPN2chr19:33535154chr19:53747150ENST00000254260-215515_59361.666666666666664687.0DomainNote=PDZ
HgeneRHPN2chr19:33535155chr19:53747150ENST00000254260-215111_46061.666666666666664687.0DomainBRO1
HgeneRHPN2chr19:33535155chr19:53747150ENST00000254260-21526_10061.666666666666664687.0DomainREM-1
HgeneRHPN2chr19:33535155chr19:53747150ENST00000254260-215515_59361.666666666666664687.0DomainNote=PDZ


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Fusion Gene Sequence for RHPN2-ZNF677


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000254260_ENST00000601413_TCGA-HU-A4HD-01A_RHPN2_chr19_33535155_-_ZNF677_chr19_53747150_length(transcript)=563nt_BP=221nt
AGTCCGCCGTCCGCCCTCCGCGCCCGCGCCGCTAGCATGACCGACGCGCTGTTGCCCGCGGCCCCCCAGCCGCTGGAGAAGGAGAACGAC
GGCTACTTTCGGAAGGGCTGTAATCCCCTTGCACAAACCGGCCGGAGTAAATTGCAGAATCAAAGAGCTGCTTTGAATCAGCAGATCCTG
AAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTTCTGAAGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGT
GGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTACAGGGACGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACA
TCCCTCCAGAAGATGGTAACCACCCTTGTACATCTTTACATTTTTCCTTGTGAGTCTCTTGGGAGGCCCTGATGTGCTTGTCTGAATCCG
ATCCCTGTTCTAAAAGGGGAGATTGAAACTTTTTGATTGAGAGTGGAAAGGCTTCATAATGTAGCATATAGACTTTAAACTTCCCCTTTC

>In-frame_ENST00000254260_ENST00000601413_TCGA-HU-A4HD-01A_RHPN2_chr19_33535155_-_ZNF677_chr19_53747150_length(amino acids)=72AA_start in transcript=249_stop in transcript=31

--------------------------------------------------------------
>In-frame_ENST00000254260_ENST00000601413_TCGA-HU-A4HD_RHPN2_chr19_33535154_-_ZNF677_chr19_53747150_length(transcript)=563nt_BP=221nt
AGTCCGCCGTCCGCCCTCCGCGCCCGCGCCGCTAGCATGACCGACGCGCTGTTGCCCGCGGCCCCCCAGCCGCTGGAGAAGGAGAACGAC
GGCTACTTTCGGAAGGGCTGTAATCCCCTTGCACAAACCGGCCGGAGTAAATTGCAGAATCAAAGAGCTGCTTTGAATCAGCAGATCCTG
AAAGCCGTGCGGATGAGGACCGGAGCGGAAAACCTTCTGAAGGACTGTTTACATTCAAGGATGTGGCCATAGAATTCTCTCAAGAGGAGT
GGGAGTGCCTGGACCCTGCCCAGAGGGCCTTGTACAGGGACGTGATGTTGGAGAACTACAGGAACCTGCTTTCTCTCGATGAGGATAACA
TCCCTCCAGAAGATGGTAACCACCCTTGTACATCTTTACATTTTTCCTTGTGAGTCTCTTGGGAGGCCCTGATGTGCTTGTCTGAATCCG
ATCCCTGTTCTAAAAGGGGAGATTGAAACTTTTTGATTGAGAGTGGAAAGGCTTCATAATGTAGCATATAGACTTTAAACTTCCCCTTTC

>In-frame_ENST00000254260_ENST00000601413_TCGA-HU-A4HD_RHPN2_chr19_33535154_-_ZNF677_chr19_53747150_length(amino acids)=72AA_start in transcript=249_stop in transcript=31

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RHPN2-ZNF677


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRHPN2chr19:33535154chr19:53747150ENST00000254260-21546_6661.666666666666664687.0Rho
HgeneRHPN2chr19:33535155chr19:53747150ENST00000254260-21546_6661.666666666666664687.0Rho


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RHPN2-ZNF677


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RHPN2-ZNF677


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRHPN2C0009402Colorectal Carcinoma1CTD_human
HgeneRHPN2C0009404Colorectal Neoplasms1CTD_human