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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RMDN3-SKA2 (FusionGDB2 ID:73782)

Fusion Gene Summary for RMDN3-SKA2

check button Fusion gene summary
Fusion gene informationFusion gene name: RMDN3-SKA2
Fusion gene ID: 73782
HgeneTgene
Gene symbol

RMDN3

SKA2

Gene ID

55177

348235

Gene nameregulator of microtubule dynamics 3spindle and kinetochore associated complex subunit 2
SynonymsFAM82A2|FAM82C|RMD-3|RMD3|ptpip51FAM33A
Cytomap

15q15.1

17q22

Type of geneprotein-codingprotein-coding
Descriptionregulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interactingspindle and kinetochore-associated protein 2family with sequence similarity 33, member Aspindle and KT (kinetochore) associated 2
Modification date2020031320200313
UniProtAcc

Q96TC7

.
Ensembl transtripts involved in fusion geneENST00000260385, ENST00000338376, 
ENST00000558560, 		ENST00000330137, 
ENST00000580541, ENST00000578105, 
ENST00000583927, ENST00000581068, 
ENST00000437036, ENST00000583380, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 4 X 3=72
# samples 56
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RMDN3 [Title/Abstract] AND SKA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRMDN3(41043624)-SKA2(57189706), # samples:2
Anticipated loss of major functional domain due to fusion event.RMDN3-SKA2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSKA2

GO:0031110

regulation of microtubule polymerization or depolymerization

19289083


check buttonFusion gene breakpoints across RMDN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SKA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HI-01ARMDN3chr15

41043624

-SKA2chr17

57189706

-
ChimerDB4BRCATCGA-C8-A1HI-01ARMDN3chr15

41037175

-SKA2chr17

57196856

-
ChimerDB4BRCATCGA-C8-A1HI-01ARMDN3chr15

41043624

-SKA2chr17

57189706

-


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Fusion Gene ORF analysis for RMDN3-SKA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260385ENST00000330137RMDN3chr15

41043624

-SKA2chr17

57189706

-
Frame-shiftENST00000260385ENST00000580541RMDN3chr15

41043624

-SKA2chr17

57189706

-
Frame-shiftENST00000260385ENST00000578105RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000260385ENST00000583927RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000260385ENST00000581068RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000260385ENST00000437036RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000260385ENST00000583380RMDN3chr15

41043624

-SKA2chr17

57189706

-
Frame-shiftENST00000338376ENST00000330137RMDN3chr15

41043624

-SKA2chr17

57189706

-
Frame-shiftENST00000338376ENST00000580541RMDN3chr15

41043624

-SKA2chr17

57189706

-
In-frameENST00000338376ENST00000578105RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000338376ENST00000583927RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000338376ENST00000581068RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000338376ENST00000437036RMDN3chr15

41043624

-SKA2chr17

57189706

-
5CDS-5UTRENST00000338376ENST00000583380RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-3CDSENST00000558560ENST00000330137RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-3CDSENST00000558560ENST00000580541RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-3CDSENST00000558560ENST00000578105RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-5UTRENST00000558560ENST00000583927RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-5UTRENST00000558560ENST00000581068RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-5UTRENST00000558560ENST00000437036RMDN3chr15

41043624

-SKA2chr17

57189706

-
5UTR-5UTRENST00000558560ENST00000583380RMDN3chr15

41043624

-SKA2chr17

57189706

-
In-frameENST00000260385ENST00000330137RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000260385ENST00000580541RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000260385ENST00000578105RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000260385ENST00000583927RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000260385ENST00000581068RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000260385ENST00000437036RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000260385ENST00000583380RMDN3chr15

41037175

-SKA2chr17

57196856

-
Frame-shiftENST00000338376ENST00000330137RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000338376ENST00000580541RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000338376ENST00000578105RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000338376ENST00000583927RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000338376ENST00000581068RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000338376ENST00000437036RMDN3chr15

41037175

-SKA2chr17

57196856

-
5CDS-intronENST00000338376ENST00000583380RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-3CDSENST00000558560ENST00000330137RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-intronENST00000558560ENST00000580541RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-intronENST00000558560ENST00000578105RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-intronENST00000558560ENST00000583927RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-intronENST00000558560ENST00000581068RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-intronENST00000558560ENST00000437036RMDN3chr15

41037175

-SKA2chr17

57196856

-
intron-intronENST00000558560ENST00000583380RMDN3chr15

41037175

-SKA2chr17

57196856

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338376RMDN3chr1541043624-ENST00000578105SKA2chr1757189706-116770983721212
ENST00000260385RMDN3chr1541037175-ENST00000330137SKA2chr1757196856-4447187510322120362

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338376ENST00000578105RMDN3chr1541043624-SKA2chr1757189706-0.169842080.83015794
ENST00000260385ENST00000330137RMDN3chr1541037175-SKA2chr1757196856-0.0003045810.9996954

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Fusion Genomic Features for RMDN3-SKA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RMDN3-SKA2


check button Go to

FGviewer for the breakpoints of chr15:41043624-chr17:57189706

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RMDN3

Q96TC7

.
FUNCTION: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRMDN3chr15:41037175chr17:57196856ENST00000260385-41292_124269.0471.0Coiled coilOntology_term=ECO:0000255
HgeneRMDN3chr15:41037175chr17:57196856ENST00000338376-51392_124269.0471.0Coiled coilOntology_term=ECO:0000255
HgeneRMDN3chr15:41043624chr17:57189706ENST00000260385-31292_124174.66666666666666471.0Coiled coilOntology_term=ECO:0000255
HgeneRMDN3chr15:41043624chr17:57189706ENST00000338376-41392_124174.66666666666666471.0Coiled coilOntology_term=ECO:0000255
HgeneRMDN3chr15:41037175chr17:57196856ENST00000260385-4121_12269.0471.0Topological domainMitochondrial intermembrane
HgeneRMDN3chr15:41037175chr17:57196856ENST00000338376-5131_12269.0471.0Topological domainMitochondrial intermembrane
HgeneRMDN3chr15:41043624chr17:57189706ENST00000260385-3121_12174.66666666666666471.0Topological domainMitochondrial intermembrane
HgeneRMDN3chr15:41043624chr17:57189706ENST00000338376-4131_12174.66666666666666471.0Topological domainMitochondrial intermembrane
HgeneRMDN3chr15:41037175chr17:57196856ENST00000260385-41213_35269.0471.0TransmembraneHelical
HgeneRMDN3chr15:41037175chr17:57196856ENST00000338376-51313_35269.0471.0TransmembraneHelical
HgeneRMDN3chr15:41043624chr17:57189706ENST00000260385-31213_35174.66666666666666471.0TransmembraneHelical
HgeneRMDN3chr15:41043624chr17:57189706ENST00000338376-41313_35174.66666666666666471.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRMDN3chr15:41037175chr17:57196856ENST00000260385-41236_470269.0471.0Topological domainCytoplasmic
HgeneRMDN3chr15:41037175chr17:57196856ENST00000338376-51336_470269.0471.0Topological domainCytoplasmic
HgeneRMDN3chr15:41043624chr17:57189706ENST00000260385-31236_470174.66666666666666471.0Topological domainCytoplasmic
HgeneRMDN3chr15:41043624chr17:57189706ENST00000338376-41336_470174.66666666666666471.0Topological domainCytoplasmic


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Fusion Gene Sequence for RMDN3-SKA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000338376_ENST00000578105_TCGA-C8-A1HI-01A_RMDN3_chr15_41043624_-_SKA2_chr17_57189706_length(transcript)=1167nt_BP=709nt
GACGTCACGGTCACTGACAGCGTGAGCCCGCGGCGGCTGCTGCCATGGTGGCTGGCGGCCGGGTAAGGGTCTGAGTGGATCTCCTGCCAG
GCCAGAGCGCCTTCGGGGGCCGCGGCGGAAGGCCAGGAGTTTGCAGCCAGGGCGCCGGGTTTGTGGTCTGCAGTGTCGTGAGGCTGAGGT
GCAGCATGTCTAGACTGGGAGCCCTGGGTGGTGCCCGTGCCGGGCTGGGACTGTTGCTGGGTACCGCCGCCGGCCTTGGATTCCTGTGCC
TCCTTTACAGCCAGCGATGGAAACGGACCCAGCGTCATGGCCGCAGCCAGAGCCTGCCCAACTCCCTGGACTATACGCAGACTTCAGATC
CCGGACGCCACGTGATGCTCCTGCGGGCTGTCCCAGGTGGGGCTGGAGATGCCTCAGTGCTGCCCAGCCTTCCACGGGAAGGACAGGAGA
AGGTGCTGGACCGCCTGGACTTTGTGCTGACCAGCCTTGTGGCGCTGCGGCGGGAGGTGGAGGAGCTGAGAAGCAGCCTGCGAGGGCTTG
CGGGGGAGATTGTTGGGGAGGTCCGATGCCACATGGAAGAGAACCAGAGAGTGGCTCGGCGGCGAAGGTTTCCGTTTGTCCGGGAGAGGA
GTGACTCCACTGGCTCCAGCTCTGTCTACTTCACGGCCTCCTCGGGAGCCACGTTCACAGATGCTGAGAGTGAAGGGGGCTGTCACCACT
GACTAAAGAAGAGAAAACTGCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGA
GAAGAGCTTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCA
ATGACTGGATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGA
GAATAAAACGATTTAAATATATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGC

>In-frame_ENST00000338376_ENST00000578105_TCGA-C8-A1HI-01A_RMDN3_chr15_41043624_-_SKA2_chr17_57189706_length(amino acids)=212AA_start in transcript=83_stop in transcript=721
MPGQSAFGGRGGRPGVCSQGAGFVVCSVVRLRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQT
SDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVR

--------------------------------------------------------------
>In-frame_ENST00000260385_ENST00000330137_TCGA-C8-A1HI-01A_RMDN3_chr15_41037175_-_SKA2_chr17_57196856_length(transcript)=4447nt_BP=1875nt
TGTTATCATAGTCCATAAAATCGGTCTTTTTAGTTGCCACAATTATAAGAAGTTGCATACAATTACAAGAGTAAAACAGAATTATAAGAC
AGCACGTTAGGTTTAAGATTTATGGCCGGGTGCGGCGGCTCACGCACTTTGGGAGCCCGAGGCGGGCGGATCGCACTTTGAGAGACCAGG
AGAGCGGGACCCAGTCTCTACAAAATAAAAATAAAAATAAAATGTGGGGAGAGCGTGACGTTTTCCAGGTACAGAGGGGAGGTCCAGGCA
GAAGCGCAGGTAGAAAGTGTGAATATGCTGAGCGTATTCCGGGAGCAGCAAGTTAAGCCGGTGTGACCGGAGGGAAATGGAGGCCTGGCT
GCCGGACGGTGAGGGTGACTGCGCGAGCGTCCGCCCAAGAAGTCTCCCTGCCTTCCCGCCTTTCCCCTGTCTTGGGCCCCTTCTTGCTTT
CCTTTCGCGCTCTGTGCTGACTCCGCCCCTCCGGCGGCGCCCGTGGCCCCGCCCCTGAGGGAAACAGACAAGGGGCGGGGCCGGCGCGGT
CATCTCTCTGCGCCTTCCCGCAGGGCGCCGAGCACCTGGCGCCGCCTGCCTGACGTCACGGTCACTGACAGCGTGAGCCCGCGGCGGCTG
CTGCCATGGTGGCTGGCGGCCGGGTAAGGGTCTGAGTGGATCTCCTGCCAGGCCAGAGCGCCTTCGGGGGCCGCGGCGGAAGGCCAGGAG
TTTGCAGCCAGGGCGCCGGGTTTGTGGTCTGCAGTGTCGTGAGGCTGAGGTGGGGGTTGAAGGCCCAGAAGCCGGACTCTGTGACCCGGG
TCGGGGGGTGTACTGGAGGGGCGGCTACGTCCAGGCTGGGTGAGAAGAGAGGCAGTGGGGCCCAGGAGGCTGGAGGAAGCCTTAGGGTTC
AGACTGGGGTGCACGTAGTCGAGAGCTCAGGGTTTGGGCAAGGGGATACCTGCCGGGGTTCAGCCTTGAGGGTGGGTTTACCGGGTTCAC
GAATCTCTCTCTCTCCTTACCCCCGCCCGCCCGCCCGCCTGCCTGCTCCCGGTGACTTCTGCTGGCCGCAGGTGCAGCATGTCTAGACTG
GGAGCCCTGGGTGGTGCCCGTGCCGGGCTGGGACTGTTGCTGGGTACCGCCGCCGGCCTTGGATTCCTGTGCCTCCTTTACAGCCAGCGA
TGGAAACGGACCCAGCGTCATGGCCGCAGCCAGAGCCTGCCCAACTCCCTGGACTATACGCAGACTTCAGATCCCGGACGCCACGTGATG
CTCCTGCGGGCTGTCCCAGGTGGGGCTGGAGATGCCTCAGTGCTGCCCAGCCTTCCACGGGAAGGACAGGAGAAGGTGCTGGACCGCCTG
GACTTTGTGCTGACCAGCCTTGTGGCGCTGCGGCGGGAGGTGGAGGAGCTGAGAAGCAGCCTGCGAGGGCTTGCGGGGGAGATTGTTGGG
GAGGTCCGATGCCACATGGAAGAGAACCAGAGAGTGGCTCGGCGGCGAAGGTTTCCGTTTGTCCGGGAGAGGAGTGACTCCACTGGCTCC
AGCTCTGTCTACTTCACGGCCTCCTCGGGAGCCACGTTCACAGATGCTGAGAGTGAAGGGGGTTACACAACAGCCAATGCGGAGTCTGAC
AATGAGCGGGACTCTGACAAAGAAAGTGAGGACGGGGAAGATGAAGTGAGCTGTGAGACTGTGAAGATGGGGAGAAAGGATTCTCTTGAC
TTGGAGGAAGAGGCAGCTTCAGGTGCCTCCAGTGCCCTGGAGGCTGGAGGTTCCTCAGGCTTGGAGGATGTGCTGCCCCTCCTGCAGCAG
GCCGACGAGCTGCACAGGGGTGATGAGCAAGGCAAGCGGGAGGGCTTCCAGCTGCTGCTCAACAACAAGCTGGTGAAAAATCCAGTTACA
CTCTTAAAGGAATTGTCAGTGATAAAGTCTCGATATCAAACTTTGTATGCCCGCTTTAAACCAGTTGCTGTTGAGCAGAAAGAGAGTAAG
AGCCGCATTTGTGCTACTGTGAAAAAGACTATGAATATGATACAAAAACTACAGAAGCAAACAGACCTGGAGCTGTCACCACTGACTAAA
GAAGAGAAAACTGCGGCAGAGCAATTCAAATTTCACATGCCAGATTTATGAAGAAATGGACTTGGAAAGGAAATTCTAACAGAGAAGAGC
TTAATTCCGGAGAAATTTAGGAAGATGTCTTGTTAACCCTTGATGTCTAGAGATTGGGGGCTGGTGAAGGGGGTTTGGCTTCAATGACTG
GATAATGATATCTTTCATGAGAGAGATTATAAGAAGAAGGGCAGATAATATATGAATAAAGTTCAGCCAAAAGGATCAAATGAGAATAAA
ACGATTTAAATATATGTACACACGCATGCACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTGTT
TTCTTTTTCTAAGTCATGATAATATAGATGTTCTGGTCTATCATAAAAGAATGTTTATGTACATTTCAGTCATTCGGTATGTGGCTTTGT
AAATTAAAGTATAGGCAAAACATTTGTGTTATACATGATATATAATTTCATTTTGTAAATGTTGATTGCACATGTGGTCACATTATTGTT
GAGACTGCTTTTATGTGACCTGTAGTCTCCCACAGAACCTAAAGTAATAAGCTGGCTTTTCTGTGATAGCCACGTTTGCGTATTTCTTTC
CCTATTTCCCTTGCCTGCTAATGTTGAACAGCATGAACTTGCTTTCTGATGCTGTTTTAGACTGTCCCTGTTGTATCTCAATAATATCTT
TGTTTTCCTTCAGCCTTTATTACTATAATTGTTCATTCTACATGAAAGCTAGGAAACTGAAATTAGAAGAGCACTTATCTGCTACTTGCC
AGTTTTGCGTGAGTGTGTTATATGTATGTGTCAATTTCCCTTTAAAATAACTATTTATTTTAAAATAACTATTGGCAATAAGGAAACTGT
TCAAAGTAGAGGCAGATCTTGATAGAAAGATGTTAATCACAGGGTTGTTTATAATAGCAATATACATACACATTTGGCTAGTACTAGGTG
AATAGGAAAATAAATCATGCTGTATGTATACAATAAGAGGTCAAGTTGCCAATAAATTATTACTGTTAATGTTCTGGGAAATGCTGAAAC
TATGCTAAGTGGGGGAGAGGGAAAGCAGGTATTGCAGTTTTGTAGTGAAGATTGGGCTTTGGAGTCATATCTGAGATGTAAGTAGCAGCT
TTTAAATTCTAGCTATGACCCTGTGCAGATCACTTAACTTTTGAGTGTCAGGATGTTTGGAAGGACAAGACAGGAAAGTGTTTTAATACA
GGGTTCAGTATTTAGTAAGCCTTCAATAAGTGATATTACATACATGTAATAAAAACTAAGCATTGAAAGGACTAGGAAAAATGCATCAAA
TGTTAGTTCTGCAGGTTATAGAATTATACTTTTATGTAATTTTAAAATTTCAGTTATGAACATGTTTGTCCATTAACAAACTTATAATAG
CTGAAAAACAGGGTTGTGAGAACAGCTTCAGTTAAAATTGTCCTGTCTAGTTTGAATATTTCAAGAACAGAAAGCCTTTTTTTTTTTTTT
TTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAATGCAGTGGTACGCTCTCAGCTCACTGCAACCTCCACCTCCCAGGTTC
AAGCAGTTCTCTGCCCCACCCTCCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGAT
GGGGCTTCACCATCTTGACCAGGCTGGTCTTTAACTCCTGATGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATG
AGCTACCGTGCCTGGCCCCCTTTTTTTTAATTACAGAGAAATAAGTTACACCTTAGTATCAGATATTAATTTTCTTCAGTGTTCAGGCAA
TTAGTATTTAGAAAGCTCTTGTCATGAGATGGCTCTGGGATGTGATGATGATTGTTGGGATTGAAAAAACGGTAGTATCATGGAGAGATC
ATAATAAATTCTTAGTATTAAAAGTGGTTTTGCTTTCAGTTAGGGAGAAAAATTAGATTGTACTATTTTTCCTCTATGATTTCCTTCAGT
TATCTTCCAAATGTTGTTTTTTCCCCACAGCCCCCTTAACATTGTTCTCTATGCACTTCTCAATACATTTTCATTTGTTTCTCAAGCCTC
TTTGTGGATGACTCCTAAATATAACTTCTTCCACTAGCTCTAGATCCGTATTTCCAATAAAATCCCCTACCTGAATATTCAAGTTAAACA
TGTCCAGAATACTTACTGATTTTATTGTTAATAGCCACTATTCTGTTGTCTGGAATTAAAACCTGTATAACTAATTTGCATCCCTTTATC

>In-frame_ENST00000260385_ENST00000330137_TCGA-C8-A1HI-01A_RMDN3_chr15_41037175_-_SKA2_chr17_57196856_length(amino acids)=362AA_start in transcript=1032_stop in transcript=2120
MLPVTSAGRRCSMSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASV
LPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFT
DAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKRE
GFQLLLNNKLVKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKKTMNMIQKLQKQTDLELSPLTKEEKTAAEQFKFHMP

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Fusion Gene PPI Analysis for RMDN3-SKA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RMDN3-SKA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RMDN3-SKA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource