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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RND3-B2M (FusionGDB2 ID:74198)

Fusion Gene Summary for RND3-B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: RND3-B2M
Fusion gene ID: 74198
HgeneTgene
Gene symbol

RND3

B2M

Gene ID

390

567

Gene nameRho family GTPase 3beta-2-microglobulin
SynonymsARHE|Rho8|RhoE|memBIMD43
Cytomap

2q23.3

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionrho-related GTP-binding protein RhoEprotein MemBras homolog gene family, member Erho-related GTP-binding protein Rho8small GTP binding protein Rho8beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2020031320200329
UniProtAcc.

P61769

Ensembl transtripts involved in fusion geneENST00000375734, ENST00000263895, 
ENST00000409557, ENST00000472416, 
ENST00000558401, ENST00000559916, 
ENST00000544417, ENST00000559220, 
Fusion gene scores* DoF score6 X 6 X 2=7264 X 31 X 17=33728
# samples 671
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(71/33728*10)=-5.56998393724517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RND3 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRND3(151343208)-B2M(45007621), # samples:1
Anticipated loss of major functional domain due to fusion event.RND3-B2M seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RND3-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RND3-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:0007611

learning or memory

26147761

TgeneB2M

GO:0050680

negative regulation of epithelial cell proliferation

28213472

TgeneB2M

GO:0050768

negative regulation of neurogenesis

26147761

TgeneB2M

GO:0090647

modulation of age-related behavioral decline

26147761

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039

TgeneB2M

GO:1990000

amyloid fibril formation

28468825

TgeneB2M

GO:2000774

positive regulation of cellular senescence

28213472

TgeneB2M

GO:2000978

negative regulation of forebrain neuron differentiation

26147761


check buttonFusion gene breakpoints across RND3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-8238-01ARND3chr2

151343208

-B2Mchr15

45007621

+


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Fusion Gene ORF analysis for RND3-B2M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375734ENST00000558401RND3chr2

151343208

-B2Mchr15

45007621

+
In-frameENST00000375734ENST00000559916RND3chr2

151343208

-B2Mchr15

45007621

+
Frame-shiftENST00000375734ENST00000544417RND3chr2

151343208

-B2Mchr15

45007621

+
5CDS-intronENST00000375734ENST00000559220RND3chr2

151343208

-B2Mchr15

45007621

+
In-frameENST00000263895ENST00000558401RND3chr2

151343208

-B2Mchr15

45007621

+
In-frameENST00000263895ENST00000559916RND3chr2

151343208

-B2Mchr15

45007621

+
Frame-shiftENST00000263895ENST00000544417RND3chr2

151343208

-B2Mchr15

45007621

+
5CDS-intronENST00000263895ENST00000559220RND3chr2

151343208

-B2Mchr15

45007621

+
intron-3CDSENST00000409557ENST00000558401RND3chr2

151343208

-B2Mchr15

45007621

+
intron-3CDSENST00000409557ENST00000559916RND3chr2

151343208

-B2Mchr15

45007621

+
intron-3CDSENST00000409557ENST00000544417RND3chr2

151343208

-B2Mchr15

45007621

+
intron-intronENST00000409557ENST00000559220RND3chr2

151343208

-B2Mchr15

45007621

+
5UTR-3CDSENST00000472416ENST00000558401RND3chr2

151343208

-B2Mchr15

45007621

+
5UTR-3CDSENST00000472416ENST00000559916RND3chr2

151343208

-B2Mchr15

45007621

+
5UTR-3CDSENST00000472416ENST00000544417RND3chr2

151343208

-B2Mchr15

45007621

+
5UTR-intronENST00000472416ENST00000559220RND3chr2

151343208

-B2Mchr15

45007621

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375734RND3chr2151343208-ENST00000558401B2Mchr1545007621+2066488250780176
ENST00000375734RND3chr2151343208-ENST00000559916B2Mchr1545007621+1468488250780176
ENST00000263895RND3chr2151343208-ENST00000558401B2Mchr1545007621+2000422103714203
ENST00000263895RND3chr2151343208-ENST00000559916B2Mchr1545007621+1402422103714203

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375734ENST00000558401RND3chr2151343208-B2Mchr1545007621+0.0006243670.99937564
ENST00000375734ENST00000559916RND3chr2151343208-B2Mchr1545007621+0.0010186260.9989813
ENST00000263895ENST00000558401RND3chr2151343208-B2Mchr1545007621+0.0010105230.9989895
ENST00000263895ENST00000559916RND3chr2151343208-B2Mchr1545007621+0.0013034550.9986966

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Fusion Genomic Features for RND3-B2M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RND3chr2151343207-B2Mchr1545007620+0.221683730.77831626
RND3chr2151343207-B2Mchr1545007620+0.221683730.77831626

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RND3-B2M


check button Go to

FGviewer for the breakpoints of chr2:151343208-chr15:45007621

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.B2M

P61769

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRND3chr2:151343208chr15:45007621ENST00000263895-3652_6079.33333333333333245.0MotifEffector region
HgeneRND3chr2:151343208chr15:45007621ENST00000375734-2552_6079.33333333333333245.0MotifEffector region
HgeneRND3chr2:151343208chr15:45007621ENST00000263895-3630_3779.33333333333333245.0Nucleotide bindingGTP
HgeneRND3chr2:151343208chr15:45007621ENST00000263895-3677_8179.33333333333333245.0Nucleotide bindingGTP
HgeneRND3chr2:151343208chr15:45007621ENST00000375734-2530_3779.33333333333333245.0Nucleotide bindingGTP
HgeneRND3chr2:151343208chr15:45007621ENST00000375734-2577_8179.33333333333333245.0Nucleotide bindingGTP
TgeneB2Mchr2:151343208chr15:45007621ENST000005584010425_11322.333333333333332498.0DomainNote=Ig-like C1-type
TgeneB2Mchr2:151343208chr15:45007621ENST000005599160325_11322.333333333333332120.0DomainNote=Ig-like C1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRND3chr2:151343208chr15:45007621ENST00000263895-36135_13879.33333333333333245.0Nucleotide bindingGTP
HgeneRND3chr2:151343208chr15:45007621ENST00000375734-25135_13879.33333333333333245.0Nucleotide bindingGTP


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Fusion Gene Sequence for RND3-B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375734_ENST00000558401_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(transcript)=2066nt_BP=488nt
GCAGTCGGCTCGGAATTGGACTTGGGAGGCGCGGTGAGGAGTCAGGCTTAAAACTTGTTGGAGGGGAGTAACCAGCCTGCTCCTCTCGCT
CTCCTCCTCGTCTGCGCCGCGTTTCAGAGGTTGCCCATCAGCCTTGTGATTTATTTTTATATCTGCTTTTTATAAAGAGAGAAATATATA
TATATATATATATTTTTTTTTTTCTTCTTAAGAGAAAATTCCTGTTCCAAGAGAAAATAAGGCAACATCAATGAAGGAGAGAAGAGCCAG
CCAGAAATTATCCAGCAAATCTATCATGGATCCTAATCAGAACGTGAAATGCAAGATAGTTGTGGTGGGAGACAGTCAGTGTGGAAAAAC
TGCGCTGCTCCATGTCTTCGCCAAGGACTGCTTCCCCGAGAATTACGTTCCTACAGTGTTTGAGAATTACACGGCCAGTTTTGAAATCGA
CACACAAAGAATAGAGTTGAGCCTGTGGGACACTTCGGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTC
AAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGA
GCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTG
CCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGC
ATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTACACTTTATGCACAAAATGTAGGGT
TATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCAC
AGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTC
AATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAAT
TTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCATATTTACTTCTTATACATT
TGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATA
TCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGA
GTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGT
GACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAA
GAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGG
ACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGT
ATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAA
GAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGAT

>In-frame_ENST00000375734_ENST00000558401_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(amino acids)=176AA_start in transcript=250_stop in transcript=780
MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGTPKIQVYSRH

--------------------------------------------------------------
>In-frame_ENST00000375734_ENST00000559916_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(transcript)=1468nt_BP=488nt
GCAGTCGGCTCGGAATTGGACTTGGGAGGCGCGGTGAGGAGTCAGGCTTAAAACTTGTTGGAGGGGAGTAACCAGCCTGCTCCTCTCGCT
CTCCTCCTCGTCTGCGCCGCGTTTCAGAGGTTGCCCATCAGCCTTGTGATTTATTTTTATATCTGCTTTTTATAAAGAGAGAAATATATA
TATATATATATATTTTTTTTTTTCTTCTTAAGAGAAAATTCCTGTTCCAAGAGAAAATAAGGCAACATCAATGAAGGAGAGAAGAGCCAG
CCAGAAATTATCCAGCAAATCTATCATGGATCCTAATCAGAACGTGAAATGCAAGATAGTTGTGGTGGGAGACAGTCAGTGTGGAAAAAC
TGCGCTGCTCCATGTCTTCGCCAAGGACTGCTTCCCCGAGAATTACGTTCCTACAGTGTTTGAGAATTACACGGCCAGTTTTGAAATCGA
CACACAAAGAATAGAGTTGAGCCTGTGGGACACTTCGGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTC
AAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGA
GCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTG
CCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCT
TGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAGAG
TAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATG
GCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCA
AGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTT
TTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAG
GCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAG
AGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTCTACTGCCCAGGGTACATTGATGCT

>In-frame_ENST00000375734_ENST00000559916_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(amino acids)=176AA_start in transcript=250_stop in transcript=780
MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGTPKIQVYSRH

--------------------------------------------------------------
>In-frame_ENST00000263895_ENST00000558401_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(transcript)=2000nt_BP=422nt
AAAGCCGCGCAGAGAGCGTGAAACAAAGCAGTCGGCTCGGAATTGGACTTGGGAGGCGCGGTGAGGAGTCAGGCTTAAAACTTGTTGGAG
GGGAGTAACCAGCCTGCTCCTCTCGCTCTCCTCCTCGTCTGCGCCGCGTTTCAGAGAGAAAATTCCTGTTCCAAGAGAAAATAAGGCAAC
ATCAATGAAGGAGAGAAGAGCCAGCCAGAAATTATCCAGCAAATCTATCATGGATCCTAATCAGAACGTGAAATGCAAGATAGTTGTGGT
GGGAGACAGTCAGTGTGGAAAAACTGCGCTGCTCCATGTCTTCGCCAAGGACTGCTTCCCCGAGAATTACGTTCCTACAGTGTTTGAGAA
TTACACGGCCAGTTTTGAAATCGACACACAAAGAATAGAGTTGAGCCTGTGGGACACTTCGGGTACTCCAAAGATTCAGGTTTACTCACG
TCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAA
TGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCC
CACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGC
ATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTA
CACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTG
ATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAAC
ATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATAC
TCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAG
ATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATA
AAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAA
AAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAA
GAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGG
TCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGG
TCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCA
TATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTG
TTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGAT
CCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAATAACAGATTTAAAATTTTCA

>In-frame_ENST00000263895_ENST00000558401_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(amino acids)=203AA_start in transcript=103_stop in transcript=714
MLLSLSSSSAPRFREKIPVPRENKATSMKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTAS
FEIDTQRIELSLWDTSGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKD

--------------------------------------------------------------
>In-frame_ENST00000263895_ENST00000559916_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(transcript)=1402nt_BP=422nt
AAAGCCGCGCAGAGAGCGTGAAACAAAGCAGTCGGCTCGGAATTGGACTTGGGAGGCGCGGTGAGGAGTCAGGCTTAAAACTTGTTGGAG
GGGAGTAACCAGCCTGCTCCTCTCGCTCTCCTCCTCGTCTGCGCCGCGTTTCAGAGAGAAAATTCCTGTTCCAAGAGAAAATAAGGCAAC
ATCAATGAAGGAGAGAAGAGCCAGCCAGAAATTATCCAGCAAATCTATCATGGATCCTAATCAGAACGTGAAATGCAAGATAGTTGTGGT
GGGAGACAGTCAGTGTGGAAAAACTGCGCTGCTCCATGTCTTCGCCAAGGACTGCTTCCCCGAGAATTACGTTCCTACAGTGTTTGAGAA
TTACACGGCCAGTTTTGAAATCGACACACAAAGAATAGAGTTGAGCCTGTGGGACACTTCGGGTACTCCAAAGATTCAGGTTTACTCACG
TCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAA
TGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCC
CACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGC
ATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTC
ACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGA
AGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGC
AGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCAC
TCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTG
TGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTA
ACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTC

>In-frame_ENST00000263895_ENST00000559916_TCGA-HU-8238-01A_RND3_chr2_151343208_-_B2M_chr15_45007621_length(amino acids)=203AA_start in transcript=103_stop in transcript=714
MLLSLSSSSAPRFREKIPVPRENKATSMKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTAS
FEIDTQRIELSLWDTSGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKD

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Fusion Gene PPI Analysis for RND3-B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RND3-B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneB2MP61769DB09130CopperSmall moleculeApproved|Investigational
TgeneB2MP61769DB09130CopperSmall moleculeApproved|Investigational
TgeneB2MP61769DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for RND3-B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRND3C2239176Liver carcinoma1CTD_human
TgeneB2MC0022658Kidney Diseases3CTD_human
TgeneB2MC0022660Kidney Failure, Acute3CTD_human
TgeneB2MC1565662Acute Kidney Insufficiency3CTD_human
TgeneB2MC2609414Acute kidney injury3CTD_human
TgeneB2MC1855796Hypoproteinemia, Hypercatabolic2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneB2MC0004364Autoimmune Diseases1CTD_human
TgeneB2MC0013221Drug toxicity1CTD_human
TgeneB2MC0018799Heart Diseases1CTD_human
TgeneB2MC0020455Hypergammaglobulinemia1CTD_human
TgeneB2MC0033578Prostatic Neoplasms1CTD_human
TgeneB2MC0041755Adverse reaction to drug1CTD_human
TgeneB2MC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneB2MC0079774Peripheral T-Cell Lymphoma1CTD_human
TgeneB2MC0268389Amyloidosis, familial visceral1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneB2MC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneB2MC0376358Malignant neoplasm of prostate1CTD_human
TgeneB2MC1858266Bare Lymphocyte Syndrome, Type I1ORPHANET
TgeneB2MC4302669Autosomal dominant beta2-microglobulinic amyloidosis1ORPHANET