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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RNF13-ATP8A2 (FusionGDB2 ID:74306) |
Fusion Gene Summary for RNF13-ATP8A2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RNF13-ATP8A2 | Fusion gene ID: 74306 | Hgene | Tgene | Gene symbol | RNF13 | ATP8A2 | Gene ID | 11342 | 51761 |
Gene name | ring finger protein 13 | ATPase phospholipid transporting 8A2 | |
Synonyms | EIEE73|RZF | ATP|ATPIB|CAMRQ4|IB|ML-1 | |
Cytomap | 3q25.1 | 13q12.13 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RNF13RING zinc finger proteinRING-type E3 ubiquitin transferase RNF13 | phospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | Q9NTI2 | |
Ensembl transtripts involved in fusion gene | ENST00000392894, ENST00000344229, ENST00000361785, | ENST00000381655, ENST00000255283, ENST00000491840, | |
Fusion gene scores | * DoF score | 10 X 9 X 7=630 | 13 X 13 X 7=1183 |
# samples | 13 | 15 | |
** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1183*10)=-2.97941566784391 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RNF13 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RNF13(149570383)-ATP8A2(26273311), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across RNF13 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ATP8A2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A7-A4SE-01A | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
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Fusion Gene ORF analysis for RNF13-ATP8A2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000392894 | ENST00000381655 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
In-frame | ENST00000392894 | ENST00000255283 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
5CDS-3UTR | ENST00000392894 | ENST00000491840 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
In-frame | ENST00000344229 | ENST00000381655 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
In-frame | ENST00000344229 | ENST00000255283 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
5CDS-3UTR | ENST00000344229 | ENST00000491840 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
intron-3CDS | ENST00000361785 | ENST00000381655 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
intron-3CDS | ENST00000361785 | ENST00000255283 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
intron-3UTR | ENST00000361785 | ENST00000491840 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000392894 | RNF13 | chr3 | 149570383 | - | ENST00000381655 | ATP8A2 | chr13 | 26273311 | + | 8079 | 857 | 662 | 2212 | 516 |
ENST00000392894 | RNF13 | chr3 | 149570383 | - | ENST00000255283 | ATP8A2 | chr13 | 26273311 | + | 2394 | 857 | 662 | 2137 | 491 |
ENST00000344229 | RNF13 | chr3 | 149570383 | - | ENST00000381655 | ATP8A2 | chr13 | 26273311 | + | 8119 | 897 | 702 | 2252 | 516 |
ENST00000344229 | RNF13 | chr3 | 149570383 | - | ENST00000255283 | ATP8A2 | chr13 | 26273311 | + | 2434 | 897 | 702 | 2177 | 491 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000392894 | ENST00000381655 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + | 0.000673992 | 0.999326 |
ENST00000392894 | ENST00000255283 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + | 0.003653481 | 0.99634653 |
ENST00000344229 | ENST00000381655 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + | 0.000728399 | 0.9992716 |
ENST00000344229 | ENST00000255283 | RNF13 | chr3 | 149570383 | - | ATP8A2 | chr13 | 26273311 | + | 0.004145431 | 0.9958546 |
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Fusion Genomic Features for RNF13-ATP8A2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RNF13-ATP8A2 |
Go to FGviewer for the breakpoints of chr3:149570383-chr13:26273311 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | ATP8A2 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. {ECO:0000250|UniProtKB:C7EXK4}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 1019_1028 | 737.0 | 1189.0 | Topological domain | Cytoplasmic | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 1050_1063 | 737.0 | 1189.0 | Topological domain | Extracellular | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 1085_1188 | 737.0 | 1189.0 | Topological domain | Cytoplasmic | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 909_910 | 737.0 | 1189.0 | Topological domain | Extracellular | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 932_959 | 737.0 | 1189.0 | Topological domain | Cytoplasmic | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 981_997 | 737.0 | 1189.0 | Topological domain | Extracellular | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 1029_1049 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 1064_1084 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 888_908 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 911_931 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 960_980 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 998_1018 | 737.0 | 1189.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000344229 | - | 4 | 11 | 65_160 | 65.0 | 382.0 | Domain | Note=PA |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000392894 | - | 3 | 10 | 65_160 | 65.0 | 382.0 | Domain | Note=PA |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000344229 | - | 4 | 11 | 204_381 | 65.0 | 382.0 | Topological domain | Cytoplasmic |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000344229 | - | 4 | 11 | 35_182 | 65.0 | 382.0 | Topological domain | Lumenal |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000392894 | - | 3 | 10 | 204_381 | 65.0 | 382.0 | Topological domain | Cytoplasmic |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000392894 | - | 3 | 10 | 35_182 | 65.0 | 382.0 | Topological domain | Lumenal |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000344229 | - | 4 | 11 | 183_203 | 65.0 | 382.0 | Transmembrane | Helical |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000392894 | - | 3 | 10 | 183_203 | 65.0 | 382.0 | Transmembrane | Helical |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000344229 | - | 4 | 11 | 240_282 | 65.0 | 382.0 | Zinc finger | RING-type%3B atypical |
Hgene | RNF13 | chr3:149570383 | chr13:26273311 | ENST00000392894 | - | 3 | 10 | 240_282 | 65.0 | 382.0 | Zinc finger | RING-type%3B atypical |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 116_119 | 737.0 | 1189.0 | Topological domain | Extracellular | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 141_316 | 737.0 | 1189.0 | Topological domain | Cytoplasmic | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 1_94 | 737.0 | 1189.0 | Topological domain | Cytoplasmic | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 338_364 | 737.0 | 1189.0 | Topological domain | Extracellular | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 386_887 | 737.0 | 1189.0 | Topological domain | Cytoplasmic | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 120_140 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 317_337 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 365_385 | 737.0 | 1189.0 | Transmembrane | Helical | |
Tgene | ATP8A2 | chr3:149570383 | chr13:26273311 | ENST00000381655 | 23 | 37 | 95_115 | 737.0 | 1189.0 | Transmembrane | Helical |
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Fusion Gene Sequence for RNF13-ATP8A2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000392894_ENST00000381655_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(transcript)=8079nt_BP=857nt CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCCACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGA ATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACCCTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCC TGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCTCTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGG TGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATGATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATG AAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCCTACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCT ACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTCCTGTATATTATTGAGCTTTGGTTCGCCTTTGTTAATGGAT TTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTGATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTG AGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCT GGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTG GTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAG CTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCA TTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCT GTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTC GAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGC CCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGG AAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATT CAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTA GCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAG TGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATAT TTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACA CTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTCC TGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTT GAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCCGCACCCTCTCCAGGTGCACTCGGCCCAGTCC TGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCC AAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAG AAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAGA ACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAG AACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTTATAACATGCCTGCACAGCGAAGGAACACACC TGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAG TCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATA GGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAAT TCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATC AGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACTTTCCCAACTGCAGAGTCCCACACTTAAATCT CAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTT GCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACT GTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACCC TGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGG CATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGAGGTGACCAGGATGCAGAGAGGGCCTGAGGGG CAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTA CCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTG CACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTGT CTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTT CCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTTACATTAGAGTTCATATTTTCTGGGATTTAAG GATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGA GATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTC ACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACAC AACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCG CCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTGACTCTGGATTGAGCTAAACTGGCAGAATCCA CTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGA GACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGA GCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAGT GCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAAAAACATGGTAACTCT TTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAACACTTGTAGAGGAATATCCTGAGAAGTGAACC TGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCT GTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGT ATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATCT TGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAA ACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTTTCAGCCAGGGTTTGAGTTACTGCCCAGGGTC ATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGG GAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACAC TCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAAA ATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATT CTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTTTCGGAGGTGAGGGCCCAAGACCCCCATAATG ACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAG TTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTT GTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAGC CACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGG CTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTTTCAAGTGACAATCTCGGGCTCTAGTTGCCTT TGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGC TGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGT TGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCCG TGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTT AAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAAAAAAAAAAAAAAAAAAGGAAGAAAAGAAAAA AAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGA AACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTC CCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTTT GTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGG GAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCTCCCAGCAGCGTGGGGGGTGCTTCTATGGTGT GTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTAC AGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGC >In-frame_ENST00000392894_ENST00000381655_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(amino acids)=516AA_start in transcript=662_stop in transcript=2212 MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR FPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVW GSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDS -------------------------------------------------------------- >In-frame_ENST00000392894_ENST00000255283_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(transcript)=2394nt_BP=857nt CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCCACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGA ATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACCCTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCC TGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCTCTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGG TGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATGATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATG AAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCCTACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCT ACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTCCTGTATATTATTGAGATTTTCACCGCTTTGCCGCCCTTCA CTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCA ACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATA CTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTG GTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGA CCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTC TGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGC TGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGC TGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACG GAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGAT CTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACAC ATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTC >In-frame_ENST00000392894_ENST00000255283_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(amino acids)=491AA_start in transcript=662_stop in transcript=2137 MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIEIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCIN ALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPD MRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFR -------------------------------------------------------------- >In-frame_ENST00000344229_ENST00000381655_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(transcript)=8119nt_BP=897nt CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCC ACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGAATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACC CTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCCTGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCT CTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGGTGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATG ATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATGAAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCC TACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCTACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTC CTGTATATTATTGAGCTTTGGTTCGCCTTTGTTAATGGATTTTCTGGGCAGATTTTATTTGAACGTTGGTGCATCGGCCTGTACAATGTG ATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTTCCCCAGCTCTACAAA ATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTCATCCTCTTCTGGTTT CCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATTGTTTACACATATGTT GTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGAAGCATGCTGACCTGG CTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACTATGGTCCTGAGCTCC GCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAG ACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAAC GAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGG TATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAA TAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGT CAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGAC CACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTC TGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGT TGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGC AGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTCCTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACA AAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAA GAGTCTTCCGCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGC CACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAA AATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTG TCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAGAACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCA ACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATG AATGAATTTATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAG TATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGA GGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGC TTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAATTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTT CCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAA TCACTGACTTTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTT ACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTG GTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACAC CTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACCCTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGC TTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCT CACTTATGAGGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTT TCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGC CTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGA ATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTGTCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATT CTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTT TTGTTTCTTACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTT GCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGAC TAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTC ATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACACAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCT GTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTC CAGGGCCTGACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTG TTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACAC GTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCA TAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAGTGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAA CACACACATGCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTT TCTTTTAACACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCT TGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGT GGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATA GTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATCTTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGG ATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACT GCACACTTTTCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGT AGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAG TTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCAC AATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAAAATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTT AACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTT TGAGGGGTTTCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGT GTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCC CAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGA AAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAGCCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACC CCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCT GGCGCATTTTCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACAT GCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTC AGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCA AGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTG CGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAA CAACAAAAAAAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAG ACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGC CAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGG GCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTTTGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTC ACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTT TAATTGGCTCCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCT ATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTT GTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGACTGGTGTATGTCTGCGCAAACCTGTTTCAAAT >In-frame_ENST00000344229_ENST00000381655_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(amino acids)=516AA_start in transcript=702_stop in transcript=2252 MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR FPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVW GSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDS -------------------------------------------------------------- >In-frame_ENST00000344229_ENST00000255283_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(transcript)=2434nt_BP=897nt CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGCC ACAAGGGCAGCCATTACTCAGCACTGCACTGACCTTGGGAATTTGCTGGGCAAGGAAAATGACGTGGCCCTGATCATCGATGGCCACACC CTGAAGTACGCGCTCTCCTTCGAAGTCCGGAGGAGTTTCCTGGATTTGGCACTCTCGTGCAAAGCGGTCATATGCTGCAGAGTGTCTCCT CTGCAGAAGTCTGAGATAGTGGATGTGGTGAAGAAGCGGGTGAAGGCCATCACCCTCGCCATCGGAGACGGCGCCAACGATGTCGGGATG ATCCAGACAGCCCACGTGGGTGTGGGAATCAGTGGGAATGAAGGCATGCAGGCCACCAACAACTCGGATTACGCCATCGCACAGTTTTCC TACTTAGAGAAGCTTCTGTTGGTTCATGGAGCCTGGAGCTACAACCGGGTGACCAAGTGCATCTTGTACTGCTTCTATAAGAACGTGGTC CTGTATATTATTGAGATTTTCACCGCTTTGCCGCCCTTCACTCTGGGAATCTTTGAGAGGTCTTGCACTCAGGAGAGCATGCTCAGGTTT CCCCAGCTCTACAAAATCACCCAGAATGGCGAAGGCTTCAACACAAAGGTTTTCTGGGGTCACTGCATCAACGCCTTGGTCCACTCCCTC ATCCTCTTCTGGTTTCCCATGAAAGCTCTGGAGCATGATACTGTGTTGACAAGTGGTCATGCTACCGACTATTTATTTGTTGGAAATATT GTTTACACATATGTTGTTGTTACTGTTTGTCTGAAAGCTGGTTTGGAGACCACAGCTTGGACTAAATTCAGTCATCTGGCTGTCTGGGGA AGCATGCTGACCTGGCTGGTGTTTTTTGGCATCTACTCGACCATCTGGCCCACCATTCCCATTGCTCCAGATATGAGAGGACAGGCAACT ATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAG CACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAAT GGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAG GGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAG AAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTC AGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAA ACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAG >In-frame_ENST00000344229_ENST00000255283_TCGA-A7-A4SE-01A_RNF13_chr3_149570383_-_ATP8A2_chr13_26273311_length(amino acids)=491AA_start in transcript=702_stop in transcript=2177 MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKATRAAITQHCTDLGNLLGKENDVAL IIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDY AIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIEIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCIN ALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPD MRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RNF13-ATP8A2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RNF13-ATP8A2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RNF13-ATP8A2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RNF13 | C0015544 | Failure to Thrive | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C0232466 | Feeding difficulties | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C0234398 | Visual Cortex Disorder | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C0852413 | Abnormal muscle tone | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C2677180 | Congenital microcephaly | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Hgene | RNF13 | C4048268 | Cortical visual impairment | 1 | GENOMICS_ENGLAND |
Tgene | ATP8A2 | C3808977 | CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 4 | 2 | GENOMICS_ENGLAND;UNIPROT |
Tgene | ATP8A2 | C0394006 | Dysequilibrium syndrome | 1 | ORPHANET |
Tgene | ATP8A2 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |