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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF13-TM4SF4 (FusionGDB2 ID:74315)

Fusion Gene Summary for RNF13-TM4SF4

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF13-TM4SF4
Fusion gene ID: 74315
HgeneTgene
Gene symbol

RNF13

TM4SF4

Gene ID

11342

7104

Gene namering finger protein 13transmembrane 4 L six family member 4
SynonymsEIEE73|RZFILTMP|il-TMP
Cytomap

3q25.1

3q25.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF13RING zinc finger proteinRING-type E3 ubiquitin transferase RNF13transmembrane 4 L6 family member 4intestinal and liver (il) tetraspan membrane proteinintestine and liver tetraspan membrane proteintransmembrane 4 superfamily member 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000392894, ENST00000344229, 
ENST00000361785, 		ENST00000305354, 
Fusion gene scores* DoF score10 X 9 X 7=6305 X 6 X 6=180
# samples 138
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF13 [Title/Abstract] AND TM4SF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF13(149531140)-TM4SF4(149216509), # samples:3
RNF13(149589941)-TM4SF4(149205406), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TM4SF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01ARNF13chr3

149531140

+TM4SF4chr3

149216509

+
ChimerDB4GBMTCGA-4W-AA9R-01ARNF13chr3

149570383

+TM4SF4chr3

149193610

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

+TM4SF4chr3

149192762

+
ChimerDB4UCSTCGA-N5-A4RA-01ARNF13chr3

149589941

+TM4SF4chr3

149205406

+
ChimerDB4BRCATCGA-A7-A26G-01ARNF13chr3

149531140

+TM4SF4chr3

149216509

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

+TM4SF4chr3

149192762

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

+TM4SF4chr3

149205406

+
ChimerDB4UCSTCGA-N5-A4RARNF13chr3

149589941

+TM4SF4chr3

149205406

+
ChimerDB4OVTCGA-13-1495-01ARNF13chr3

149531140

-TM4SF4chr3

149193610

+
ChimerDB4BRCATCGA-A7-A26G-01ARNF13chr3

149531140

-TM4SF4chr3

149216509

+
ChimerDB4UCSTCGA-N5-A4RA-01ARNF13chr3

149589941

-TM4SF4chr3

149205406

+


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Fusion Gene ORF analysis for RNF13-TM4SF4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149216509

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149216509

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149216509

+
In-frameENST00000392894ENST00000305354RNF13chr3

149570383

+TM4SF4chr3

149193610

+
In-frameENST00000344229ENST00000305354RNF13chr3

149570383

+TM4SF4chr3

149193610

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149570383

+TM4SF4chr3

149193610

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149192762

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149192762

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149192762

+
In-frameENST00000392894ENST00000305354RNF13chr3

149589941

+TM4SF4chr3

149205406

+
In-frameENST00000344229ENST00000305354RNF13chr3

149589941

+TM4SF4chr3

149205406

+
5UTR-3CDSENST00000361785ENST00000305354RNF13chr3

149589941

+TM4SF4chr3

149205406

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149205406

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149205406

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

+TM4SF4chr3

149205406

+
5UTR-3CDSENST00000392894ENST00000305354RNF13chr3

149531140

-TM4SF4chr3

149193610

+
5UTR-3CDSENST00000344229ENST00000305354RNF13chr3

149531140

-TM4SF4chr3

149193610

+
intron-3CDSENST00000361785ENST00000305354RNF13chr3

149531140

-TM4SF4chr3

149193610

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392894RNF13chr3149570383+ENST00000305354TM4SF4chr3149193610+18808576621291209
ENST00000344229RNF13chr3149570383+ENST00000305354TM4SF4chr3149193610+19208977021331209
ENST00000392894RNF13chr3149589941+ENST00000305354TM4SF4chr3149205406+19169836621327221
ENST00000344229RNF13chr3149589941+ENST00000305354TM4SF4chr3149205406+195610237021367221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392894ENST00000305354RNF13chr3149570383+TM4SF4chr3149193610+0.0015970590.9984029
ENST00000344229ENST00000305354RNF13chr3149570383+TM4SF4chr3149193610+0.0020369210.9979631
ENST00000392894ENST00000305354RNF13chr3149589941+TM4SF4chr3149205406+0.0010270120.998973
ENST00000344229ENST00000305354RNF13chr3149589941+TM4SF4chr3149205406+0.0016445650.99835545

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Fusion Genomic Features for RNF13-TM4SF4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF13chr3149531140+TM4SF4chr3149216508+1.52E-050.99998486
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149570383+TM4SF4chr3149193609+9.42E-070.99999905
RNF13chr3149531140+TM4SF4chr3149205405+3.42E-081
RNF13chr3149531140+TM4SF4chr3149216508+1.52E-050.99998486
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149589941+TM4SF4chr3149205405+1.17E-050.9999883
RNF13chr3149570383+TM4SF4chr3149193609+9.42E-070.99999905
RNF13chr3149531140+TM4SF4chr3149205405+3.42E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF13-TM4SF4


check button Go to

FGviewer for the breakpoints of chr3:149570383-chr3:149193610

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTM4SF4chr3:149570383chr3:149193610ENST0000030535405115_15858.0203.0Topological domainExtracellular
TgeneTM4SF4chr3:149570383chr3:149193610ENST0000030535405180_20258.0203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540567_9358.0203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149589941chr3:149205406ENST0000030535415115_15888.0203.0Topological domainExtracellular
TgeneTM4SF4chr3:149589941chr3:149205406ENST0000030535415180_20288.0203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST0000030535405159_17958.0203.0TransmembraneHelical
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540594_11458.0203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST0000030535415159_17988.0203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541594_11488.0203.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+41165_16065.0382.0DomainNote=PA
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+31065_16065.0382.0DomainNote=PA
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+51165_160107.0382.0DomainNote=PA
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+41065_160107.0382.0DomainNote=PA
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+411204_38165.0382.0Topological domainCytoplasmic
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+41135_18265.0382.0Topological domainLumenal
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+310204_38165.0382.0Topological domainCytoplasmic
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+31035_18265.0382.0Topological domainLumenal
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+511204_381107.0382.0Topological domainCytoplasmic
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+51135_182107.0382.0Topological domainLumenal
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+410204_381107.0382.0Topological domainCytoplasmic
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+41035_182107.0382.0Topological domainLumenal
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+411183_20365.0382.0TransmembraneHelical
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+310183_20365.0382.0TransmembraneHelical
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+511183_203107.0382.0TransmembraneHelical
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+410183_203107.0382.0TransmembraneHelical
HgeneRNF13chr3:149570383chr3:149193610ENST00000344229+411240_28265.0382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149570383chr3:149193610ENST00000392894+310240_28265.0382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149589941chr3:149205406ENST00000344229+511240_282107.0382.0Zinc fingerRING-type%3B atypical
HgeneRNF13chr3:149589941chr3:149205406ENST00000392894+410240_282107.0382.0Zinc fingerRING-type%3B atypical
TgeneTM4SF4chr3:149570383chr3:149193610ENST00000305354051_958.0203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540531_4558.0203.0Topological domainExtracellular
TgeneTM4SF4chr3:149589941chr3:149205406ENST00000305354151_988.0203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541531_4588.0203.0Topological domainExtracellular
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541567_9388.0203.0Topological domainCytoplasmic
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540510_3058.0203.0TransmembraneHelical
TgeneTM4SF4chr3:149570383chr3:149193610ENST000003053540546_6658.0203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541510_3088.0203.0TransmembraneHelical
TgeneTM4SF4chr3:149589941chr3:149205406ENST000003053541546_6688.0203.0TransmembraneHelical


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Fusion Gene Sequence for RNF13-TM4SF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000392894_ENST00000305354_TCGA-4W-AA9R-01A_RNF13_chr3_149570383_+_TM4SF4_chr3_149193610_length(transcript)=1880nt_BP=857nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGATGATCTTCCCTGCGCTGGTGTTCTTGGGCCTGAAGAACAATG
ACTGCTGTGGGTGCTGCGGCAACGAGGGCTGTGGGAAGCGATTTGCGATGTTCACCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAG
CTGGATACTCGTTTATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAATGCCTCATGGCCAATAGTACATGGGGCTACCCCTTCCACG
ACGGGGATTATCTCAATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCTCTCAATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCC
TGCTGGTCGTAGGAGGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTCAATGGCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTT
GTGGCTGCTGTGGGGGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGCTCAGACTCTACAGCATGACGACTACAATTTCTTTTCATAA
AACTTCTTCTCTTCTTGGAATTATTAATTCCTATCTGCTTCCTAGCTGATAAAGCTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGC
TTTGCTCGAGTTAGAATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCACTTAACAAATTTGATTTATAAATCTTTCAAATTAGTTCCT
TTTTAGAATTTACCAACAGGTTCAAAGCATACTTTTCATGATTTTTTTATTACAAATGTAAAATGTATAAAGTCACATGTACTGCCATAC
TACTTCTTTGTATATAAAGATGTTTATATCTTTGGAAGTTTTACATAAATCAAAGGAAGAAAGCACATTTAAAATGAGAAACTAAGACCA
ATTTCTGTTTTTAAGAGGAAAAAGAATGATTGATGTATCCTAAGTATTGTTATTTGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTG

>In-frame_ENST00000392894_ENST00000305354_TCGA-4W-AA9R-01A_RNF13_chr3_149570383_+_TM4SF4_chr3_149193610_length(amino acids)=209AA_start in transcript=662_stop in transcript=1291
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKMIFPALVFLGLKNNDCCGCCGNEGC
GKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVL

--------------------------------------------------------------
>In-frame_ENST00000344229_ENST00000305354_TCGA-4W-AA9R-01A_RNF13_chr3_149570383_+_TM4SF4_chr3_149193610_length(transcript)=1920nt_BP=897nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGATG
ATCTTCCCTGCGCTGGTGTTCTTGGGCCTGAAGAACAATGACTGCTGTGGGTGCTGCGGCAACGAGGGCTGTGGGAAGCGATTTGCGATG
TTCACCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAGCTGGATACTCGTTTATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAA
TGCCTCATGGCCAATAGTACATGGGGCTACCCCTTCCACGACGGGGATTATCTCAATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCT
CTCAATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCCTGCTGGTCGTAGGAGGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTC
AATGGCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTTGTGGCTGCTGTGGGGGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGC
TCAGACTCTACAGCATGACGACTACAATTTCTTTTCATAAAACTTCTTCTCTTCTTGGAATTATTAATTCCTATCTGCTTCCTAGCTGAT
AAAGCTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGCTTTGCTCGAGTTAGAATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCA
CTTAACAAATTTGATTTATAAATCTTTCAAATTAGTTCCTTTTTAGAATTTACCAACAGGTTCAAAGCATACTTTTCATGATTTTTTTAT
TACAAATGTAAAATGTATAAAGTCACATGTACTGCCATACTACTTCTTTGTATATAAAGATGTTTATATCTTTGGAAGTTTTACATAAAT
CAAAGGAAGAAAGCACATTTAAAATGAGAAACTAAGACCAATTTCTGTTTTTAAGAGGAAAAAGAATGATTGATGTATCCTAAGTATTGT
TATTTGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTGTGACTGATCTTTTGAGGCTGTCATCATGGCTAGGGTTCTTTTATGTATGT

>In-frame_ENST00000344229_ENST00000305354_TCGA-4W-AA9R-01A_RNF13_chr3_149570383_+_TM4SF4_chr3_149193610_length(amino acids)=209AA_start in transcript=702_stop in transcript=1331
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKMIFPALVFLGLKNNDCCGCCGNEGC
GKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFSILLVVGGIQMVL

--------------------------------------------------------------
>In-frame_ENST00000392894_ENST00000305354_TCGA-N5-A4RA-01A_RNF13_chr3_149589941_+_TM4SF4_chr3_149205406_length(transcript)=1916nt_BP=983nt
CTCTTTAGTAGGTCGGGTGAGTGTAGTGTGCAGGGAAGAGACGCGTCAGCGCCAGGGCCAGGCCCGCCCGGGGGCAGCCCGGCAGCCGAA
TCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGTCCCGCGCCCTCCAGACCCTACGGTCTCC
GTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCCCTTCCTCTGCCAAGAGCAGCTTCTTCAG
CCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATCACGCGGCCAAGAACGAGACTCGCAAACT
GGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGCCTTAACAGGCAACCATGTTGCCCAGTGG
GTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTAGGTGTTGTCGTCCCTGCTAGTACTCCGG
GCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGACGCGGCTGGCAAGACTGTTTGTGTTGCG
GGGGCCGGACTTCAAGGTGATTTTACAACGAGATGCTGCTCTCCATAGGGATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGA
CTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATTTTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATG
ACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGGTTTTTTGATTAACTCAAAACCAGAGAATGCCTGTGAACCCA
TAGTGCCTCCACCAGTAAAAGACAATTCATCTGGCACTTTCATCGTGTTAATTAGAAGACTTGATTGTAATTTTGATATAAAGATGTTCA
CCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAGCTGGATACTCGTTTATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAATGCC
TCATGGCCAATAGTACATGGGGCTACCCCTTCCACGACGGGGATTATCTCAATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCTCTCA
ATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCCTGCTGGTCGTAGGAGGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTCAATG
GCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTTGTGGCTGCTGTGGGGGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGCTCAG
ACTCTACAGCATGACGACTACAATTTCTTTTCATAAAACTTCTTCTCTTCTTGGAATTATTAATTCCTATCTGCTTCCTAGCTGATAAAG
CTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGCTTTGCTCGAGTTAGAATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCACTTA
ACAAATTTGATTTATAAATCTTTCAAATTAGTTCCTTTTTAGAATTTACCAACAGGTTCAAAGCATACTTTTCATGATTTTTTTATTACA
AATGTAAAATGTATAAAGTCACATGTACTGCCATACTACTTCTTTGTATATAAAGATGTTTATATCTTTGGAAGTTTTACATAAATCAAA
GGAAGAAAGCACATTTAAAATGAGAAACTAAGACCAATTTCTGTTTTTAAGAGGAAAAAGAATGATTGATGTATCCTAAGTATTGTTATT
TGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTGTGACTGATCTTTTGAGGCTGTCATCATGGCTAGGGTTCTTTTATGTATGTTAAA

>In-frame_ENST00000392894_ENST00000305354_TCGA-N5-A4RA-01A_RNF13_chr3_149589941_+_TM4SF4_chr3_149205406_length(amino acids)=221AA_start in transcript=662_stop in transcript=1327
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSS
GTFIVLIRRLDCNFDIKMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFS

--------------------------------------------------------------
>In-frame_ENST00000344229_ENST00000305354_TCGA-N5-A4RA-01A_RNF13_chr3_149589941_+_TM4SF4_chr3_149205406_length(transcript)=1956nt_BP=1023nt
CCCGCCCGGGGGCAGCCCGGCAGCCGAATCTTGGGCTACTCTGTCCCAACAGCCGGAGCAGATCAGACCGACCGGCCCTGCCCGCTCGGT
CCCGCGCCCTCCAGACCCTACGGTCTCCGTTTCTAGGGGCACATGGTTAGCGGCAGGCGCCCACAGCCAATCCACTTTGCCAGCCTGCCC
CTTCCTCTGCCAAGAGCAGCTTCTTCAGCCGCGCTCCAGTTCCGCAGACGCCTGCCCCACCCTGCTCTTCCCTTCCAGGGAAGACGGATC
ACGCGGCCAAGAACGAGACTCGCAAACTGGGCATTTCTCCGAGCCGGGCTAGAGCAAGTAGCGAGACTCCGCGTGAGAGTGGGAAAGAGC
CTTAACAGGCAACCATGTTGCCCAGTGGGTTTTCTGTGCCTTTGGGTGCGGACCAATGAGGCGCGTGGGGCGGGACTTCCGCTTCGCCTA
GGTGTTGTCGTCCCTGCTAGTACTCCGGGCTGTGGGGGTCGGTGCGGATATTCAGTCATGAAATCAGGGTAGGGACTTCTCCCGCAGCGA
CGCGGCTGGCAAGACTGTTTGTGTTGCGGGGGCCGGACTTCAAGAGAGAAAGAGAGAGTGGGCAGACATCGAAGCCAAACAGCAGTATCC
CGGAAGCACTCATGCAACTTTGGTGGCGGCCACTCAGTTTTCTCTGCCAGTGTCTGGTGATTTTACAACGAGATGCTGCTCTCCATAGGG
ATGCTCATGCTGTCAGCCACACAAGTCTACACCATCTTGACTGTCCAGCTCTTTGCATTCTTAAACCTACTGCCTGTAGAAGCAGACATT
TTAGCATATAACTTTGAAAATGCATCTCAGACATTTGATGACCTCCCTGCAAGATTTGGTTATAGACTTCCAGCTGAAGGTTTAAAGGGT
TTTTTGATTAACTCAAAACCAGAGAATGCCTGTGAACCCATAGTGCCTCCACCAGTAAAAGACAATTCATCTGGCACTTTCATCGTGTTA
ATTAGAAGACTTGATTGTAATTTTGATATAAAGATGTTCACCTCCACGATATTTGCTGTGGTTGGATTCTTGGGAGCTGGATACTCGTTT
ATCATCTCAGCCATTTCAATCAACAAGGGTCCTAAATGCCTCATGGCCAATAGTACATGGGGCTACCCCTTCCACGACGGGGATTATCTC
AATGATGAGGCCTTATGGAACAAGTGCCGAGAGCCTCTCAATGTGGTTCCCTGGAATCTGACCCTCTTCTCCATCCTGCTGGTCGTAGGA
GGAATCCAGATGGTTCTCTGCGCCATCCAGGTGGTCAATGGCCTCCTGGGGACCCTCTGTGGGGACTGCCAGTGTTGTGGCTGCTGTGGG
GGAGATGGACCCGTTTAAACCTCCGAGATGAGCTGCTCAGACTCTACAGCATGACGACTACAATTTCTTTTCATAAAACTTCTTCTCTTC
TTGGAATTATTAATTCCTATCTGCTTCCTAGCTGATAAAGCTTAGAAAAGGCAGTTATTCCTTCTTTCCAACCAGCTTTGCTCGAGTTAG
AATTTTGTTATTTTCAAATAAAAAATAGTTTGGCCACTTAACAAATTTGATTTATAAATCTTTCAAATTAGTTCCTTTTTAGAATTTACC
AACAGGTTCAAAGCATACTTTTCATGATTTTTTTATTACAAATGTAAAATGTATAAAGTCACATGTACTGCCATACTACTTCTTTGTATA
TAAAGATGTTTATATCTTTGGAAGTTTTACATAAATCAAAGGAAGAAAGCACATTTAAAATGAGAAACTAAGACCAATTTCTGTTTTTAA
GAGGAAAAAGAATGATTGATGTATCCTAAGTATTGTTATTTGTTGTCTTTTTTTGCTGCCTTGCTTGAGTTGCTTGTGACTGATCTTTTG

>In-frame_ENST00000344229_ENST00000305354_TCGA-N5-A4RA-01A_RNF13_chr3_149589941_+_TM4SF4_chr3_149205406_length(amino acids)=221AA_start in transcript=702_stop in transcript=1367
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSS
GTFIVLIRRLDCNFDIKMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDEALWNKCREPLNVVPWNLTLFS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF13-TM4SF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF13-TM4SF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF13-TM4SF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF13C0015544Failure to Thrive1GENOMICS_ENGLAND
HgeneRNF13C0018784Sensorineural Hearing Loss (disorder)1GENOMICS_ENGLAND
HgeneRNF13C0036572Seizures1GENOMICS_ENGLAND
HgeneRNF13C0232466Feeding difficulties1GENOMICS_ENGLAND
HgeneRNF13C0234398Visual Cortex Disorder1GENOMICS_ENGLAND
HgeneRNF13C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneRNF13C0852413Abnormal muscle tone1GENOMICS_ENGLAND
HgeneRNF13C2677180Congenital microcephaly1GENOMICS_ENGLAND
HgeneRNF13C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneRNF13C4048268Cortical visual impairment1GENOMICS_ENGLAND
TgeneTM4SF4C0023895Liver diseases1CTD_human
TgeneTM4SF4C0086565Liver Dysfunction1CTD_human