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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF144B-NUP153 (FusionGDB2 ID:74354)

Fusion Gene Summary for RNF144B-NUP153

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF144B-NUP153
Fusion gene ID: 74354
HgeneTgene
Gene symbol

RNF144B

NUP153

Gene ID

255488

9972

Gene namering finger protein 144Bnucleoporin 153
SynonymsIBRDC2|PIR2|bA528A10.3|p53RFPHNUP153|N153
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF144BIBR domain containing 2IBR domain-containing protein 2p53-inducible RING finger proteinnuclear pore complex protein Nup153153 kDa nucleoporinnuclear pore complex protein hnup153nucleoporin 153kDnucleoporin 153kDanucleoporin Nup153
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000429054, ENST00000259939, 
ENST00000486622, 		ENST00000262077, 
ENST00000537253, 
Fusion gene scores* DoF score11 X 5 X 7=38512 X 11 X 4=528
# samples 914
** MAII scorelog2(9/385*10)=-2.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF144B [Title/Abstract] AND NUP153 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF144B(18399930)-NUP153(17649531), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF144B

GO:0006511

ubiquitin-dependent protein catabolic process

12853982

HgeneRNF144B

GO:0043066

negative regulation of apoptotic process

20300062

TgeneNUP153

GO:0046832

negative regulation of RNA export from nucleus

22253824


check buttonFusion gene breakpoints across RNF144B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUP153 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GY-01ARNF144Bchr6

18399930

+NUP153chr6

17649531

-


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Fusion Gene ORF analysis for RNF144B-NUP153

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000429054ENST00000262077RNF144Bchr6

18399930

+NUP153chr6

17649531

-
intron-3CDSENST00000429054ENST00000537253RNF144Bchr6

18399930

+NUP153chr6

17649531

-
In-frameENST00000259939ENST00000262077RNF144Bchr6

18399930

+NUP153chr6

17649531

-
In-frameENST00000259939ENST00000537253RNF144Bchr6

18399930

+NUP153chr6

17649531

-
3UTR-3CDSENST00000486622ENST00000262077RNF144Bchr6

18399930

+NUP153chr6

17649531

-
3UTR-3CDSENST00000486622ENST00000537253RNF144Bchr6

18399930

+NUP153chr6

17649531

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000259939RNF144Bchr618399930+ENST00000262077NUP153chr617649531-457448221535141099
ENST00000259939RNF144Bchr618399930+ENST00000537253NUP153chr617649531-356948221535141099

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259939ENST00000262077RNF144Bchr618399930+NUP153chr617649531-0.0004442340.99955577
ENST00000259939ENST00000537253RNF144Bchr618399930+NUP153chr617649531-0.0009834450.9990165

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Fusion Genomic Features for RNF144B-NUP153


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF144B-NUP153


check button Go to

FGviewer for the breakpoints of chr6:18399930-chr6:17649531

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221350_1475465.01476.0Region(Microbial infection) Interacts with HIV-1 capsid protein p24 (CA)
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221000_1001465.01476.0Repeat9
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221024_1025465.01476.0Repeat10
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221084_1085465.01476.0Repeat11
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221118_1119465.01476.0Repeat12
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221135_1136465.01476.0Repeat13
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221173_1174465.01476.0Repeat14
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221212_1213465.01476.0Repeat15
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221228_1229465.01476.0Repeat16
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221240_1241465.01476.0Repeat17
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221275_1276465.01476.0Repeat18
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221289_1290465.01476.0Repeat19
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221291_1292465.01476.0Repeat20
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221306_1307465.01476.0Repeat21
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221319_1320465.01476.0Repeat22
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221327_1328465.01476.0Repeat23
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221341_1342465.01476.0Repeat24
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221362_1363465.01476.0Repeat25
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221374_1375465.01476.0Repeat26
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221383_1384465.01476.0Repeat27
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221397_1398465.01476.0Repeat28
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710221417_1418465.01476.0Repeat29
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022652_653465.01476.0Repeat2
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022715_716465.01476.0Repeat3
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022786_787465.01476.0Repeat4
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022905_906465.01476.0Repeat5
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022926_927465.01476.0Repeat6
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022961_962465.01476.0Repeat7
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022983_984465.01476.0Repeat8
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022657_687465.01476.0Zinc fingerRanBP2-type 1
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022722_751465.01476.0Zinc fingerRanBP2-type 2
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022793_822465.01476.0Zinc fingerRanBP2-type 3
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022851_880465.01476.0Zinc fingerRanBP2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF144Bchr6:18399930chr6:17649531ENST00000259939+2826_24455.0304.0RegionTRIAD supradomain
HgeneRNF144Bchr6:18399930chr6:17649531ENST00000259939+28258_27855.0304.0TransmembraneHelical
HgeneRNF144Bchr6:18399930chr6:17649531ENST00000259939+28101_16655.0304.0Zinc fingerIBR-type
HgeneRNF144Bchr6:18399930chr6:17649531ENST00000259939+28193_22255.0304.0Zinc fingerRING-type 2%3B atypical
HgeneRNF144Bchr6:18399930chr6:17649531ENST00000259939+2830_8055.0304.0Zinc fingerRING-type 1
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022443_447465.01476.0Compositional biasNote=Poly-Gly
TgeneNUP153chr6:18399930chr6:17649531ENST0000026207710224_14465.01476.0Compositional biasNote=Gly-rich
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022236_1418465.01476.0Region29 X 2 AA repeats of F-G
TgeneNUP153chr6:18399930chr6:17649531ENST000002620771022236_237465.01476.0Repeat1


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Fusion Gene Sequence for RNF144B-NUP153


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000259939_ENST00000262077_TCGA-HU-A4GY-01A_RNF144B_chr6_18399930_+_NUP153_chr6_17649531_length(transcript)=4574nt_BP=482nt
GAGCTGTGCCCCACGCTCCCGCTGCAACAGTCCCGGGCATCGCAGCTGCCAGTCAAGGCTAGGAGGCGGTCGGGGACTCCGCCTCCTCCC
GACCCGTAGGTCTGGGAGCGCAAGTCCTGTTGCAGTCTTGCAAAGTGTAAAGCTGTCAGCCGCAGAGCACGGAGGAAAGACGGAGAGAAT
GGAAGAGCTCCTGTCCGGTGTGCCAGCAGCCCGGACTGGCGGTGAGCGCGAGGGAGGCTACTGAGAAGCCCGGCGACGGAGGAACGCAGG
TCTGCTGCCAGGGATTGAGGAGACTGAAGAATGCTGAAGACAGGCTGATGGGCTCAGCTGGTAGGCTCCACTATCTCGCCATGACTGCTG
AAAATCCCACTCCTGGAGACCTGGCTCCGGCCCCCCTCATCACTTGCAAACTCTGCCTGTGTGAGCAGTCTCTGGACAAGATGACCACAC
TCCAGGAATGCCAGTGCATCTTTTGCACAGCTGAAATGGAAGTTCCAGTATTACCGAAAATCTCTCTACCGATCACCAGTTCTTCACTGC
CTACCTTTAATTTTAGTTCCCCTGAGATCACAACTTCCTCTCCATCACCCATCAATTCGTCTCAAGCATTAACAAACAAGGTACAAATGA
CCTCTCCGAGCAGCACTGGCAGTCCCATGTTTAAATTTTCATCTCCAATCGTAAAATCTACTGAGGCAAATGTACTACCTCCATCATCTA
TTGGATTTACATTTAGTGTGCCTGTTGCAAAAACAGCAGAACTTTCTGGTTCTAGTAGTACTTTAGAACCAATTATAAGTAGTTCAGCTC
ATCATGTCACTACAGTGAACAGTACAAATTGTAAGAAGACACCACCTGAAGATTGTGAGGGTCCTTTTAGACCTGCAGAAATCCTGAAAG
AAGGAAGTGTTCTAGATATTCTGAAAAGCCCTGGTTTCGCATCGCCGAAGATAGATTCTGTTGCTGCTCAGCCCACCGCAACAAGCCCAG
TAGTTTATACAAGACCAGCAATAAGTAGCTTTTCTTCTAGTGGAATTGGGTTTGGGGAGAGTTTAAAAGCTGGGTCATCATGGCAGTGTG
ATACATGTCTACTCCAGAACAAAGTTACAGACAACAAATGCATAGCCTGTCAAGCAGCAAAATTGTCACCCAGAGATACTGCTAAACAGA
CTGGAATTGAAACACCAAATAAAAGTGGCAAAACAACTCTTTCTGCATCAGGGACAGGCTTTGGAGACAAATTTAAACCAGTGATAGGCA
CTTGGGATTGTGATACCTGTTTAGTGCAAAATAAACCTGAAGCAATAAAATGTGTAGCCTGTGAAACACCGAAACCTGGAACTTGTGTGA
AGCGAGCCCTTACATTGACAGTGGTTTCGGAAAGTGCTGAGACTATGACTGCTTCATCTTCCAGCTGCACTGTAACCACTGGTACCTTAG
GATTTGGAGATAAATTCAAAAGGCCCATTGGATCTTGGGAGTGTTCAGTATGCTGTGTTTCTAATAATGCAGAAGACAATAAGTGTGTGT
CCTGTATGTCTGAGAAACCAGGAAGTTCAGTACCTGCTTCAAGTAGCAGCACTGTACCTGTCTCTCTGCCTTCTGGAGGCTCTCTAGGAT
TGGAAAAGTTCAAGAAACCCGAGGGAAGCTGGGACTGTGAATTGTGCCTAGTGCAGAATAAGGCAGACTCTACCAAATGTTTGGCATGTG
AAAGTGCAAAGCCAGGCACAAAATCTGGGTTTAAAGGCTTTGACACATCTTCCTCATCTTCGAACTCAGCAGCCTCCTCATCCTTCAAAT
TTGGTGTCTCATCATCCTCTTCTGGGCCTTCTCAGACTTTAACAAGCACTGGAAATTTTAAATTTGGAGATCAGGGAGGATTCAAAATAG
GTGTGTCATCCGATTCTGGGTCTATAAACCCCATGAGTGAAGGCTTTAAATTTTCTAAACCAATAGGAGATTTTAAATTTGGAGTTTCAT
CTGAATCTAAGCCCGAAGAAGTTAAAAAAGATAGTAAGAATGATAATTTTAAGTTTGGACTTTCTTCTGGTTTAAGCAACCCAGTTTCTT
TAACTCCATTTCAATTTGGGGTATCTAATCTTGGACAGGAAGAAAAGAAAGAGGAACTGCCCAAATCTTCCTCTGCAGGTTTTAGCTTTG
GTACAGGTGTTATTAACTCCACCCCTGCTCCTGCTAACACCATAGTGACCTCTGAGAACAAGAGCAGCTTCAACCTTGGAACCATAGAAA
CCAAGAGTGCTTCAGTGGCTCCTTTCACATGTAAGACATCAGAAGCTAAAAAAGAAGAAATGCCTGCCACCAAAGGAGGATTCTCTTTTG
GCAACGTGGAGCCTGCCTCTCTGCCATCTGCCTCAGTGTTTGTTTTGGGAAGGACAGAAGAGAAACAGCAAGAGCCTGTCACTTCTACTT
CCCTAGTTTTTGGGAAGAAAGCTGACAATGAAGAGCCAAAGTGTCAACCAGTGTTTTCCTTTGGGAATTCAGAGCAAACCAAAGATGAGA
ATTCTTCAAAGTCCACATTTAGTTTTAGTATGACAAAACCATCTGAGAAGGAATCTGAACAGCCAGCAAAAGCCACTTTTGCCTTTGGAG
CTCAAACTAGTACTACAGCTGATCAAGGTGCAGCAAAGCCAGTTTTTAGTTTCTTGAACAACAGTTCCTCTAGTTCAAGTACACCAGCCA
CTTCTGCTGGTGGTGGCATATTTGGTAGTTCCACCTCTTCCTCCAATCCACCTGTGGCTACCTTTGTGTTTGGACAGTCCAGCAATCCTG
TGAGCAGCTCTGCCTTTGGTAACACTGCTGAATCCAGCACCTCTCAGTCTTTGCTATTTTCTCAAGATAGCAAACTAGCAACCACATCCA
GCACAGGTACAGCTGTCACCCCATTTGTCTTTGGTCCAGGAGCCAGCAGTAATAATACTACCACCTCTGGTTTCGGCTTTGGAGCCACAA
CCACATCTAGCTCTGCAGGATCCTCCTTTGTATTTGGAACTGGACCCTCAGCACCATCTGCCAGTCCAGCATTTGGTGCTAACCAGACCC
CAACATTTGGACAAAGTCAAGGTGCCAGCCAGCCCAATCCCCCAGGCTTTGGATCTATATCATCTTCCACAGCATTATTTCCCACTGGTT
CTCAGCCTGCACCACCTACTTTTGGGACAGTGTCAAGCAGTAGCCAGCCCCCTGTGTTTGGACAGCAACCTAGTCAGTCTGCATTTGGCT
CTGGAACAACTCCTAATTCTAGTTCGGCTTTCCAGTTTGGCAGCAGCACTACAAATTTCAACTTCACAAACAACAGTCCATCAGGAGTGT
TCACATTTGGTGCAAATTCTAGCACACCTGCAGCCTCAGCCCAGCCTTCAGGCTCGGGGGGCTTTCCATTTAACCAGTCTCCAGCAGCAT
TTACAGTGGGGTCAAATGGGAAAAATGTGTTCTCTTCTTCTGGAACTTCATTCTCTGGTCGCAAGATAAAGACTGCTGTTAGACGCAGGA
AATAAAGGTCACATTGGTGTTGTACTCAATTTTAACAACAGCTGGTGCCCTGCTTTCAGATACTGGATTGTACTTTGTGCTGGGGTTATC
TGAAGTCAGATCTGCCTAAGGACTTCTTTAATTTTGGAATTTTCCTCCTTTCTCTTTCGTTACAGAAGCCCCACCCTGCCTCACCCACCC
TTTTTTAAATAAATAAATAGCTAGACTGGTGACTGATTCTTCAGCAAAAATATTTTATGATCCAGCAGATTATTCACTGATTTGACATAG
TCTGGCTGTACCCAGGAATGGAGCCTGCACGGTGAATGGCTTTGTATAGAACCTCTTTGTCTACACCATTATGTGCGCTGATAAGCGTTC
ATGGAACGCGTTGAAATTGTAATTATATCTGAGGAATTCTGTATAGATTAGAATTCTGTATAGATTAGAGAGTGTTGAAACGGATGATTT
CTATGCTGAGTTTGTGCTGGTGTATGTGTGAAGTGAGTGAGTTGGGTGTATTGTGCGCTAAACTTTTCTGATAGAGGAAGCCTGATTAAA
GAATGGTCCGTGCTAAGGACTTGTTAGATCTAGTTCACTCTCCATTTAATAATTATATGCTATTTCTATATTTTCATTCTCCTATCACCT
GTCTTGCCTTTTTCATTATTTTATTATGAAACTTGTGTAAATACAATTTTGTTTCTGTACTTTTTGGCATAACATAAATCTGTGAACTTG
AAATTTGAATTTTGTGTTAGAGATTTTTTTGTTGTTTGTTTAGTCTTGTCTCAGATTTTATTATGTAAATCCCATTATTCAAAGTTGCCT
AAATCCATTTGGAAATCTTTAAAAAAAAAATTGGGGATTCTTAAAGTTGAATTTATTGGCTTTTCTGATCCAGTTTTGTTTGGACCAAAA
ACCAGTATTGTACAAAGTATTAAGCATATATTTTTATATTTACTAAAATGGACTGTGGTGACTTTGGATAATAAGGAAAAGTTTAATATT

>In-frame_ENST00000259939_ENST00000262077_TCGA-HU-A4GY-01A_RNF144B_chr6_18399930_+_NUP153_chr6_17649531_length(amino acids)=1099AA_start in transcript=215_stop in transcript=3514
MAVSAREATEKPGDGGTQVCCQGLRRLKNAEDRLMGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTAE
MEVPVLPKISLPITSSSLPTFNFSSPEITTSSPSPINSSQALTNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPPSSIGFTFSVPVAKT
AELSGSSSTLEPIISSSAHHVTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPKIDSVAAQPTATSPVVYTRPAISSFS
SSGIGFGESLKAGSSWQCDTCLLQNKVTDNKCIACQAAKLSPRDTAKQTGIETPNKSGKTTLSASGTGFGDKFKPVIGTWDCDTCLVQNK
PEAIKCVACETPKPGTCVKRALTLTVVSESAETMTASSSSCTVTTGTLGFGDKFKRPIGSWECSVCCVSNNAEDNKCVSCMSEKPGSSVP
ASSSSTVPVSLPSGGSLGLEKFKKPEGSWDCELCLVQNKADSTKCLACESAKPGTKSGFKGFDTSSSSSNSAASSSFKFGVSSSSSGPSQ
TLTSTGNFKFGDQGGFKIGVSSDSGSINPMSEGFKFSKPIGDFKFGVSSESKPEEVKKDSKNDNFKFGLSSGLSNPVSLTPFQFGVSNLG
QEEKKEELPKSSSAGFSFGTGVINSTPAPANTIVTSENKSSFNLGTIETKSASVAPFTCKTSEAKKEEMPATKGGFSFGNVEPASLPSAS
VFVLGRTEEKQQEPVTSTSLVFGKKADNEEPKCQPVFSFGNSEQTKDENSSKSTFSFSMTKPSEKESEQPAKATFAFGAQTSTTADQGAA
KPVFSFLNNSSSSSSTPATSAGGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLLFSQDSKLATTSSTGTAVTPFVFG
PGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPGFGSISSSTALFPTGSQPAPPTFGTVS
SSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNVFS

--------------------------------------------------------------
>In-frame_ENST00000259939_ENST00000537253_TCGA-HU-A4GY-01A_RNF144B_chr6_18399930_+_NUP153_chr6_17649531_length(transcript)=3569nt_BP=482nt
GAGCTGTGCCCCACGCTCCCGCTGCAACAGTCCCGGGCATCGCAGCTGCCAGTCAAGGCTAGGAGGCGGTCGGGGACTCCGCCTCCTCCC
GACCCGTAGGTCTGGGAGCGCAAGTCCTGTTGCAGTCTTGCAAAGTGTAAAGCTGTCAGCCGCAGAGCACGGAGGAAAGACGGAGAGAAT
GGAAGAGCTCCTGTCCGGTGTGCCAGCAGCCCGGACTGGCGGTGAGCGCGAGGGAGGCTACTGAGAAGCCCGGCGACGGAGGAACGCAGG
TCTGCTGCCAGGGATTGAGGAGACTGAAGAATGCTGAAGACAGGCTGATGGGCTCAGCTGGTAGGCTCCACTATCTCGCCATGACTGCTG
AAAATCCCACTCCTGGAGACCTGGCTCCGGCCCCCCTCATCACTTGCAAACTCTGCCTGTGTGAGCAGTCTCTGGACAAGATGACCACAC
TCCAGGAATGCCAGTGCATCTTTTGCACAGCTGAAATGGAAGTTCCAGTATTACCGAAAATCTCTCTACCGATCACCAGTTCTTCACTGC
CTACCTTTAATTTTAGTTCCCCTGAGATCACAACTTCCTCTCCATCACCCATCAATTCGTCTCAAGCATTAACAAACAAGGTACAAATGA
CCTCTCCGAGCAGCACTGGCAGTCCCATGTTTAAATTTTCATCTCCAATCGTAAAATCTACTGAGGCAAATGTACTACCTCCATCATCTA
TTGGATTTACATTTAGTGTGCCTGTTGCAAAAACAGCAGAACTTTCTGGTTCTAGTAGTACTTTAGAACCAATTATAAGTAGTTCAGCTC
ATCATGTCACTACAGTGAACAGTACAAATTGTAAGAAGACACCACCTGAAGATTGTGAGGGTCCTTTTAGACCTGCAGAAATCCTGAAAG
AAGGAAGTGTTCTAGATATTCTGAAAAGCCCTGGTTTCGCATCGCCGAAGATAGATTCTGTTGCTGCTCAGCCCACCGCAACAAGCCCAG
TAGTTTATACAAGACCAGCAATAAGTAGCTTTTCTTCTAGTGGAATTGGGTTTGGGGAGAGTTTAAAAGCTGGGTCATCATGGCAGTGTG
ATACATGTCTACTCCAGAACAAAGTTACAGACAACAAATGCATAGCCTGTCAAGCAGCAAAATTGTCACCCAGAGATACTGCTAAACAGA
CTGGAATTGAAACACCAAATAAAAGTGGCAAAACAACTCTTTCTGCATCAGGGACAGGCTTTGGAGACAAATTTAAACCAGTGATAGGCA
CTTGGGATTGTGATACCTGTTTAGTGCAAAATAAACCTGAAGCAATAAAATGTGTAGCCTGTGAAACACCGAAACCTGGAACTTGTGTGA
AGCGAGCCCTTACATTGACAGTGGTTTCGGAAAGTGCTGAGACTATGACTGCTTCATCTTCCAGCTGCACTGTAACCACTGGTACCTTAG
GATTTGGAGATAAATTCAAAAGGCCCATTGGATCTTGGGAGTGTTCAGTATGCTGTGTTTCTAATAATGCAGAAGACAATAAGTGTGTGT
CCTGTATGTCTGAGAAACCAGGAAGTTCAGTACCTGCTTCAAGTAGCAGCACTGTACCTGTCTCTCTGCCTTCTGGAGGCTCTCTAGGAT
TGGAAAAGTTCAAGAAACCCGAGGGAAGCTGGGACTGTGAATTGTGCCTAGTGCAGAATAAGGCAGACTCTACCAAATGTTTGGCATGTG
AAAGTGCAAAGCCAGGCACAAAATCTGGGTTTAAAGGCTTTGACACATCTTCCTCATCTTCGAACTCAGCAGCCTCCTCATCCTTCAAAT
TTGGTGTCTCATCATCCTCTTCTGGGCCTTCTCAGACTTTAACAAGCACTGGAAATTTTAAATTTGGAGATCAGGGAGGATTCAAAATAG
GTGTGTCATCCGATTCTGGGTCTATAAACCCCATGAGTGAAGGCTTTAAATTTTCTAAACCAATAGGAGATTTTAAATTTGGAGTTTCAT
CTGAATCTAAGCCCGAAGAAGTTAAAAAAGATAGTAAGAATGATAATTTTAAGTTTGGACTTTCTTCTGGTTTAAGCAACCCAGTTTCTT
TAACTCCATTTCAATTTGGGGTATCTAATCTTGGACAGGAAGAAAAGAAAGAGGAACTGCCCAAATCTTCCTCTGCAGGTTTTAGCTTTG
GTACAGGTGTTATTAACTCCACCCCTGCTCCTGCTAACACCATAGTGACCTCTGAGAACAAGAGCAGCTTCAACCTTGGAACCATAGAAA
CCAAGAGTGCTTCAGTGGCTCCTTTCACATGTAAGACATCAGAAGCTAAAAAAGAAGAAATGCCTGCCACCAAAGGAGGATTCTCTTTTG
GCAACGTGGAGCCTGCCTCTCTGCCATCTGCCTCAGTGTTTGTTTTGGGAAGGACAGAAGAGAAACAGCAAGAGCCTGTCACTTCTACTT
CCCTAGTTTTTGGGAAGAAAGCTGACAATGAAGAGCCAAAGTGTCAACCAGTGTTTTCCTTTGGGAATTCAGAGCAAACCAAAGATGAGA
ATTCTTCAAAGTCCACATTTAGTTTTAGTATGACAAAACCATCTGAGAAGGAATCTGAACAGCCAGCAAAAGCCACTTTTGCCTTTGGAG
CTCAAACTAGTACTACAGCTGATCAAGGTGCAGCAAAGCCAGTTTTTAGTTTCTTGAACAACAGTTCCTCTAGTTCAAGTACACCAGCCA
CTTCTGCTGGTGGTGGCATATTTGGTAGTTCCACCTCTTCCTCCAATCCACCTGTGGCTACCTTTGTGTTTGGACAGTCCAGCAATCCTG
TGAGCAGCTCTGCCTTTGGTAACACTGCTGAATCCAGCACCTCTCAGTCTTTGCTATTTTCTCAAGATAGCAAACTAGCAACCACATCCA
GCACAGGTACAGCTGTCACCCCATTTGTCTTTGGTCCAGGAGCCAGCAGTAATAATACTACCACCTCTGGTTTCGGCTTTGGAGCCACAA
CCACATCTAGCTCTGCAGGATCCTCCTTTGTATTTGGAACTGGACCCTCAGCACCATCTGCCAGTCCAGCATTTGGTGCTAACCAGACCC
CAACATTTGGACAAAGTCAAGGTGCCAGCCAGCCCAATCCCCCAGGCTTTGGATCTATATCATCTTCCACAGCATTATTTCCCACTGGTT
CTCAGCCTGCACCACCTACTTTTGGGACAGTGTCAAGCAGTAGCCAGCCCCCTGTGTTTGGACAGCAACCTAGTCAGTCTGCATTTGGCT
CTGGAACAACTCCTAATTCTAGTTCGGCTTTCCAGTTTGGCAGCAGCACTACAAATTTCAACTTCACAAACAACAGTCCATCAGGAGTGT
TCACATTTGGTGCAAATTCTAGCACACCTGCAGCCTCAGCCCAGCCTTCAGGCTCGGGGGGCTTTCCATTTAACCAGTCTCCAGCAGCAT
TTACAGTGGGGTCAAATGGGAAAAATGTGTTCTCTTCTTCTGGAACTTCATTCTCTGGTCGCAAGATAAAGACTGCTGTTAGACGCAGGA

>In-frame_ENST00000259939_ENST00000537253_TCGA-HU-A4GY-01A_RNF144B_chr6_18399930_+_NUP153_chr6_17649531_length(amino acids)=1099AA_start in transcript=215_stop in transcript=3514
MAVSAREATEKPGDGGTQVCCQGLRRLKNAEDRLMGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTAE
MEVPVLPKISLPITSSSLPTFNFSSPEITTSSPSPINSSQALTNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPPSSIGFTFSVPVAKT
AELSGSSSTLEPIISSSAHHVTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPKIDSVAAQPTATSPVVYTRPAISSFS
SSGIGFGESLKAGSSWQCDTCLLQNKVTDNKCIACQAAKLSPRDTAKQTGIETPNKSGKTTLSASGTGFGDKFKPVIGTWDCDTCLVQNK
PEAIKCVACETPKPGTCVKRALTLTVVSESAETMTASSSSCTVTTGTLGFGDKFKRPIGSWECSVCCVSNNAEDNKCVSCMSEKPGSSVP
ASSSSTVPVSLPSGGSLGLEKFKKPEGSWDCELCLVQNKADSTKCLACESAKPGTKSGFKGFDTSSSSSNSAASSSFKFGVSSSSSGPSQ
TLTSTGNFKFGDQGGFKIGVSSDSGSINPMSEGFKFSKPIGDFKFGVSSESKPEEVKKDSKNDNFKFGLSSGLSNPVSLTPFQFGVSNLG
QEEKKEELPKSSSAGFSFGTGVINSTPAPANTIVTSENKSSFNLGTIETKSASVAPFTCKTSEAKKEEMPATKGGFSFGNVEPASLPSAS
VFVLGRTEEKQQEPVTSTSLVFGKKADNEEPKCQPVFSFGNSEQTKDENSSKSTFSFSMTKPSEKESEQPAKATFAFGAQTSTTADQGAA
KPVFSFLNNSSSSSSTPATSAGGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLLFSQDSKLATTSSTGTAVTPFVFG
PGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPGFGSISSSTALFPTGSQPAPPTFGTVS
SSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNVFS

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Fusion Gene PPI Analysis for RNF144B-NUP153


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF144B-NUP153


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF144B-NUP153


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRNF144BC0014170Endometrial Neoplasms1CTD_human
HgeneRNF144BC0476089Endometrial Carcinoma1CTD_human