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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF146-ECHDC1 (FusionGDB2 ID:74364)

Fusion Gene Summary for RNF146-ECHDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF146-ECHDC1
Fusion gene ID: 74364
HgeneTgene
Gene symbol

RNF146

ECHDC1

Gene ID

81847

55862

Gene namering finger protein 146ethylmalonyl-CoA decarboxylase 1
Synonyms-HEL-S-76|MMCD|dJ351K20.2
Cytomap

6q22.33

6q22.33

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF146RING-type E3 ubiquitin transferase RNF146dactylidinidunaethylmalonyl-CoA decarboxylaseenoyl CoA hydratase domain containing 1enoyl Coenzyme A hydratase domain containing 1enoyl-CoA hydratase domain-containing protein 1epididymis secretory protein Li 76methylmalonyl-CoA decarboxylase
Modification date2020031320200313
UniProtAcc.

Q9NTX5

Ensembl transtripts involved in fusion geneENST00000368314, ENST00000476956, 
ENST00000609447, ENST00000356799, 
ENST00000477776, ENST00000309649, 
ENST00000489534, ENST00000608991, 
ENST00000610153, ENST00000480444, 
ENST00000454859, ENST00000474289, 
ENST00000528402, ENST00000454591, 
ENST00000368291, ENST00000309620, 
ENST00000430841, ENST00000368289, 
ENST00000531967, ENST00000488087, 
Fusion gene scores* DoF score3 X 4 X 3=368 X 7 X 6=336
# samples 411
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF146 [Title/Abstract] AND ECHDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF146(127610430)-ECHDC1(127610646), # samples:1
RNF146(127610374)-ECHDC1(127611073), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF146

GO:0051865

protein autoubiquitination

21478859


check buttonFusion gene breakpoints across RNF146 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ECHDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE768171RNF146chr6

127610430

+ECHDC1chr6

127610646

-
ChiTaRS5.0N/ABF245573RNF146chr6

127610374

-ECHDC1chr6

127611073

-


Top

Fusion Gene ORF analysis for RNF146-ECHDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000368314ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000368314ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000368314ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000368314ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000368314ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000368314ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000368314ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000368314ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000368314ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000368314ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000476956ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000476956ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000476956ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000476956ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000476956ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000476956ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000476956ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000476956ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000476956ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000476956ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000609447ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000609447ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000609447ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000609447ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000609447ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000609447ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000609447ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000609447ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000609447ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000609447ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000356799ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000356799ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000356799ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000356799ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000356799ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000356799ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000356799ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000356799ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000356799ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000356799ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000477776ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000477776ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000477776ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000477776ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000477776ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000477776ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000477776ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000477776ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000477776ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000477776ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000309649ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000309649ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000309649ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000309649ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000309649ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000309649ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000309649ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000309649ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000309649ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000309649ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000489534ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000489534ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000489534ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000489534ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000489534ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000489534ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000489534ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000489534ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000489534ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000489534ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000608991ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000608991ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000608991ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000608991ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000608991ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000608991ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000608991ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000608991ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000608991ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000608991ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000610153ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000610153ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000610153ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000610153ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000610153ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000610153ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000610153ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000610153ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000610153ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000610153ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000480444ENST00000454859RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000480444ENST00000474289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000480444ENST00000528402RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000480444ENST00000454591RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000480444ENST00000368291RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000480444ENST00000309620RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000480444ENST00000430841RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000480444ENST00000368289RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3UTRENST00000480444ENST00000531967RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-intronENST00000480444ENST00000488087RNF146chr6

127610430

+ECHDC1chr6

127610646

-
intron-3CDSENST00000368314ENST00000454859RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000368314ENST00000474289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000528402RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000454591RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000368291RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000309620RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000430841RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000368289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000368314ENST00000531967RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-intronENST00000368314ENST00000488087RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000476956ENST00000454859RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000476956ENST00000474289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000528402RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000454591RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000368291RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000309620RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000430841RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000368289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000476956ENST00000531967RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-intronENST00000476956ENST00000488087RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000609447ENST00000454859RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000609447ENST00000474289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000528402RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000454591RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000368291RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000309620RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000430841RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000368289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000609447ENST00000531967RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-intronENST00000609447ENST00000488087RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000356799ENST00000454859RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000356799ENST00000474289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000528402RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000454591RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000368291RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000309620RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000430841RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000368289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000356799ENST00000531967RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-intronENST00000356799ENST00000488087RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000477776ENST00000454859RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3CDSENST00000477776ENST00000474289RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000477776ENST00000528402RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000477776ENST00000454591RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000477776ENST00000368291RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000477776ENST00000309620RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000477776ENST00000430841RNF146chr6

127610374

-ECHDC1chr6

127611073

-
intron-3UTRENST00000477776ENST00000368289RNF146chr6

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-ECHDC1chr6

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intron-3UTRENST00000477776ENST00000531967RNF146chr6

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intron-intronENST00000477776ENST00000488087RNF146chr6

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intron-3CDSENST00000309649ENST00000454859RNF146chr6

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intron-3CDSENST00000309649ENST00000474289RNF146chr6

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intron-3UTRENST00000309649ENST00000528402RNF146chr6

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intron-3UTRENST00000309649ENST00000454591RNF146chr6

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intron-3UTRENST00000309649ENST00000368291RNF146chr6

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intron-3UTRENST00000309649ENST00000309620RNF146chr6

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intron-3UTRENST00000309649ENST00000430841RNF146chr6

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intron-3UTRENST00000309649ENST00000368289RNF146chr6

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intron-3UTRENST00000309649ENST00000531967RNF146chr6

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intron-intronENST00000309649ENST00000488087RNF146chr6

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intron-3CDSENST00000489534ENST00000454859RNF146chr6

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intron-3CDSENST00000489534ENST00000474289RNF146chr6

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intron-3UTRENST00000489534ENST00000528402RNF146chr6

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intron-3UTRENST00000489534ENST00000454591RNF146chr6

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intron-3UTRENST00000489534ENST00000368291RNF146chr6

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intron-3UTRENST00000489534ENST00000309620RNF146chr6

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intron-3UTRENST00000489534ENST00000430841RNF146chr6

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intron-3UTRENST00000489534ENST00000368289RNF146chr6

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intron-3UTRENST00000489534ENST00000531967RNF146chr6

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intron-intronENST00000489534ENST00000488087RNF146chr6

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intron-3CDSENST00000608991ENST00000454859RNF146chr6

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intron-3CDSENST00000608991ENST00000474289RNF146chr6

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intron-3UTRENST00000608991ENST00000528402RNF146chr6

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intron-3UTRENST00000608991ENST00000454591RNF146chr6

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intron-3UTRENST00000608991ENST00000368291RNF146chr6

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intron-3UTRENST00000608991ENST00000309620RNF146chr6

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intron-3UTRENST00000608991ENST00000430841RNF146chr6

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intron-3UTRENST00000608991ENST00000368289RNF146chr6

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intron-3UTRENST00000608991ENST00000531967RNF146chr6

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intron-intronENST00000608991ENST00000488087RNF146chr6

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intron-3CDSENST00000610153ENST00000454859RNF146chr6

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intron-3CDSENST00000610153ENST00000474289RNF146chr6

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intron-3UTRENST00000610153ENST00000528402RNF146chr6

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intron-3UTRENST00000610153ENST00000454591RNF146chr6

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intron-3UTRENST00000610153ENST00000368291RNF146chr6

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intron-3UTRENST00000610153ENST00000309620RNF146chr6

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intron-3UTRENST00000610153ENST00000430841RNF146chr6

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intron-3UTRENST00000610153ENST00000368289RNF146chr6

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intron-3UTRENST00000610153ENST00000531967RNF146chr6

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intron-intronENST00000610153ENST00000488087RNF146chr6

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intron-3CDSENST00000480444ENST00000454859RNF146chr6

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intron-3CDSENST00000480444ENST00000474289RNF146chr6

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intron-3UTRENST00000480444ENST00000528402RNF146chr6

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intron-3UTRENST00000480444ENST00000454591RNF146chr6

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intron-3UTRENST00000480444ENST00000368291RNF146chr6

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intron-3UTRENST00000480444ENST00000309620RNF146chr6

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intron-3UTRENST00000480444ENST00000430841RNF146chr6

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intron-3UTRENST00000480444ENST00000368289RNF146chr6

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intron-3UTRENST00000480444ENST00000531967RNF146chr6

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intron-intronENST00000480444ENST00000488087RNF146chr6

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check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RNF146-ECHDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF146-ECHDC1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ECHDC1

Q9NTX5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RNF146-ECHDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RNF146-ECHDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF146-ECHDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF146-ECHDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneECHDC1C0019193Hepatitis, Toxic1CTD_human
TgeneECHDC1C0025202melanoma1CTD_human
TgeneECHDC1C0860207Drug-Induced Liver Disease1CTD_human
TgeneECHDC1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneECHDC1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneECHDC1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneECHDC1C4279912Chemically-Induced Liver Toxicity1CTD_human