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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RNF213-IL22RA1 (FusionGDB2 ID:74516) |
Fusion Gene Summary for RNF213-IL22RA1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RNF213-IL22RA1 | Fusion gene ID: 74516 | Hgene | Tgene | Gene symbol | RNF213 | IL22RA1 | Gene ID | 57674 | 58985 |
Gene name | ring finger protein 213 | interleukin 22 receptor subunit alpha 1 | |
Synonyms | ALO17|C17orf27|KIAA1618|MYMY2|MYSTR|NET57 | CRF2-9|IL22R|IL22R1 | |
Cytomap | 17q25.3 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterin | interleukin-22 receptor subunit alpha-1IL-22 receptor subunit alpha-1IL-22R-alpha-1IL-22RA1cytokine receptor class-II member 9cytokine receptor family 2 member 9interleukin 22 receptor, alpha 1zcytoR11 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q8N6P7 | |
Ensembl transtripts involved in fusion gene | ENST00000508628, ENST00000456466, ENST00000582970, ENST00000319921, ENST00000336301, ENST00000427003, | ENST00000270800, | |
Fusion gene scores | * DoF score | 34 X 32 X 16=17408 | 2 X 2 X 2=8 |
# samples | 41 | 2 | |
** MAII score | log2(41/17408*10)=-5.40798274174489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RNF213 [Title/Abstract] AND IL22RA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RNF213(78237577)-IL22RA1(24465204), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RNF213 | GO:0016567 | protein ubiquitination | 21799892 |
Hgene | RNF213 | GO:0051260 | protein homooligomerization | 24658080|26126547 |
Hgene | RNF213 | GO:0051865 | protein autoubiquitination | 21799892 |
Fusion gene breakpoints across RNF213 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across IL22RA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-GV-A3JZ-01A | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
ChimerDB4 | BLCA | TCGA-GV-A3JZ | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
ChimerDB4 | BLCA | TCGA-GV-A3JZ-01A | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
ChimerDB4 | BLCA | TCGA-GV-A3JZ-01A | RNF213 | chr17 | 78237577 | - | IL22RA1 | chr1 | 24465204 | - |
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Fusion Gene ORF analysis for RNF213-IL22RA1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000508628 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
In-frame | ENST00000456466 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
In-frame | ENST00000582970 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
In-frame | ENST00000319921 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
intron-3CDS | ENST00000336301 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
intron-3CDS | ENST00000427003 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000508628 | RNF213 | chr17 | 78237577 | + | ENST00000270800 | IL22RA1 | chr1 | 24465204 | - | 2958 | 242 | 145 | 1923 | 592 |
ENST00000456466 | RNF213 | chr17 | 78237577 | + | ENST00000270800 | IL22RA1 | chr1 | 24465204 | - | 2956 | 240 | 143 | 1921 | 592 |
ENST00000582970 | RNF213 | chr17 | 78237577 | + | ENST00000270800 | IL22RA1 | chr1 | 24465204 | - | 2956 | 240 | 143 | 1921 | 592 |
ENST00000319921 | RNF213 | chr17 | 78237577 | + | ENST00000270800 | IL22RA1 | chr1 | 24465204 | - | 2954 | 238 | 141 | 1919 | 592 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000508628 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - | 0.019823523 | 0.98017645 |
ENST00000456466 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - | 0.019954702 | 0.9800454 |
ENST00000582970 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - | 0.019954702 | 0.9800454 |
ENST00000319921 | ENST00000270800 | RNF213 | chr17 | 78237577 | + | IL22RA1 | chr1 | 24465204 | - | 0.019903643 | 0.9800963 |
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Fusion Genomic Features for RNF213-IL22RA1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RNF213-IL22RA1 |
Go to FGviewer for the breakpoints of chr17:78237577-chr1:24465204 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | IL22RA1 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | IL22RA1 | chr17:78237577 | chr1:24465204 | ENST00000270800 | 0 | 7 | 141_221 | 14.333333333333334 | 575.0 | Domain | Fibronectin type-III 2 | |
Tgene | IL22RA1 | chr17:78237577 | chr1:24465204 | ENST00000270800 | 0 | 7 | 17_124 | 14.333333333333334 | 575.0 | Domain | Fibronectin type-III 1 | |
Tgene | IL22RA1 | chr17:78237577 | chr1:24465204 | ENST00000270800 | 0 | 7 | 16_228 | 14.333333333333334 | 575.0 | Topological domain | Extracellular | |
Tgene | IL22RA1 | chr17:78237577 | chr1:24465204 | ENST00000270800 | 0 | 7 | 250_574 | 14.333333333333334 | 575.0 | Topological domain | Cytoplasmic | |
Tgene | IL22RA1 | chr17:78237577 | chr1:24465204 | ENST00000270800 | 0 | 7 | 229_249 | 14.333333333333334 | 575.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RNF213 | chr17:78237577 | chr1:24465204 | ENST00000319921 | + | 2 | 17 | 343_374 | 32.333333333333336 | 1064.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RNF213 | chr17:78237577 | chr1:24465204 | ENST00000508628 | + | 2 | 69 | 343_374 | 32.333333333333336 | 5257.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RNF213 | chr17:78237577 | chr1:24465204 | ENST00000582970 | + | 2 | 68 | 343_374 | 32.333333333333336 | 5208.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RNF213 | chr17:78237577 | chr1:24465204 | ENST00000319921 | + | 2 | 17 | 3997_4036 | 32.333333333333336 | 1064.0 | Zinc finger | RING-type |
Hgene | RNF213 | chr17:78237577 | chr1:24465204 | ENST00000508628 | + | 2 | 69 | 3997_4036 | 32.333333333333336 | 5257.0 | Zinc finger | RING-type |
Hgene | RNF213 | chr17:78237577 | chr1:24465204 | ENST00000582970 | + | 2 | 68 | 3997_4036 | 32.333333333333336 | 5208.0 | Zinc finger | RING-type |
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Fusion Gene Sequence for RNF213-IL22RA1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000508628_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(transcript)=2958nt_BP=242nt GACAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGC TGCCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGA GGAAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGCTCACGCCCCTGAGGACCCCTCGGATCT GCTCCAGCACGTGAAATTCCAGTCCAGCAACTTTGAAAACATCCTGACGTGGGACAGCGGGCCGGAGGGCACCCCAGACACGGTCTACAG CATCGAGTATAAGACGTACGGAGAGAGGGACTGGGTGGCAAAGAAGGGCTGTCAGCGGATCACCCGGAAGTCCTGCAACCTGACGGTGGA GACGGGCAACCTCACGGAGCTCTACTATGCCAGGGTCACCGCTGTCAGTGCGGGAGGCCGGTCAGCCACCAAGATGACTGACAGGTTCAG CTCTCTGCAGCACACTACCCTCAAGCCACCTGATGTGACCTGTATCTCCAAAGTGAGATCGATTCAGATGATTGTTCATCCTACCCCCAC GCCAATCCGTGCAGGCGATGGCCACCGGCTAACCCTGGAAGACATCTTCCATGACCTGTTCTACCACTTAGAGCTCCAGGTCAACCGCAC CTACCAAATGCACCTTGGAGGGAAGCAGAGAGAATATGAGTTCTTCGGCCTGACCCCTGACACAGAGTTCCTTGGCACCATCATGATTTG CGTTCCCACCTGGGCCAAGGAGAGTGCCCCCTACATGTGCCGAGTGAAGACACTGCCAGACCGGACATGGACCTACTCCTTCTCCGGAGC CTTCCTGTTCTCCATGGGCTTCCTCGTCGCAGTACTCTGCTACCTGAGCTACAGATATGTCACCAAGCCGCCTGCACCTCCCAACTCCCT GAACGTCCAGCGAGTCCTGACTTTCCAGCCGCTGCGCTTCATCCAGGAGCACGTCCTGATCCCTGTCTTTGACCTCAGCGGCCCCAGCAG TCTGGCCCAGCCTGTCCAGTACTCCCAGATCAGGGTGTCTGGACCCAGGGAGCCCGCAGGAGCTCCACAGCGGCATAGCCTGTCCGAGAT CACCTACTTAGGGCAGCCAGACATCTCCATCCTCCAGCCCTCCAACGTGCCACCTCCCCAGATCCTCTCCCCACTGTCCTATGCCCCAAA CGCTGCCCCTGAGGTCGGGCCCCCATCCTATGCACCTCAGGTGACCCCCGAAGCTCAATTCCCATTCTACGCCCCACAGGCCATCTCTAA GGTCCAGCCTTCCTCCTATGCCCCTCAAGCCACTCCGGACAGCTGGCCTCCCTCCTATGGGGTATGCATGGAAGGTTCTGGCAAAGACTC CCCCACTGGGACACTTTCTAGTCCTAAACACCTTAGGCCTAAAGGTCAGCTTCAGAAAGAGCCACCAGCTGGAAGCTGCATGTTAGGTGG CCTTTCTCTGCAGGAGGTGACCTCCTTGGCTATGGAGGAATCCCAAGAAGCAAAATCATTGCACCAGCCCCTGGGGATTTGCACAGACAG AACATCTGACCCAAATGTGCTACACAGTGGGGAGGAAGGGACACCACAGTACCTAAAGGGCCAGCTCCCCCTCCTCTCCTCAGTCCAGAT CGAGGGCCACCCCATGTCCCTCCCTTTGCAACCTCCTTCCCGTCCATGTTCCCCCTCGGACCAAGGTCCAAGTCCCTGGGGCCTGCTGGA GTCCCTTGTGTGTCCCAAGGATGAAGCCAAGAGCCCAGCCCCTGAGACCTCAGACCTGGAGCAGCCCACAGAACTGGATTCTCTTTTCAG AGGCCTGGCCCTGACTGTGCAGTGGGAGTCCTGAGGGGAATGGGAAAGGCTTGGTGCTTCCTCCCTGTCCCTACCCAGTGTCACATCCTT GGCTGTCAATCCCATGCCTGCCCACGCCACACACTCTGCGATCTGGCCTCAGACGGGTGCCCTTGAGAGAAGCAGAGGGAGTGGCATGCA GGGCCCCTGCCATGGGTGCGCTCCTCACCGGAGCAAAGCAGCATGATAAGGACTGCAGCGGGGGAGCTCTGGGGAGCAGCTTGTGTAGAC AAGCGCGTGCTCGCTGAGCCCTGCAAGGCAGAAATGACAGTGCAAGGAGGAAATGCAGGGAAACTCCCGAGGTCCAGAGCCCCACCTCCT AACACCATGGATTCAAAGTGCTCAGGGAATTTGCCTCTCCTTGCCCCATTCCTGGCCAGTTTCACAATCTAGCTCGACAGAGCATGAGGC CCCTGCCTCTTCTGTCATTGTTCAAAGGTGGGAAGAGAGCCTGGAAAAGAACCAGGCCTGGAAAAGAACCAGAAGGAGGCTGGGCAGAAC CAGAACAACCTGCACTTCTGCCAAGGCCAGGGCCAGCAGGACGGCAGGACTCTAGGGAGGGGTGTGGCCTGCAGCTCATTCCCAGCCAGG GCAACTGCCTGACGTTGCACGATTTCAGCTTCATTCCTCTGATAGAACAAAGCGAAATGCAGGTCCACCAGGGAGGGAGACACACAAGCC TTTTCTGCAGGCAGGAGTTTCAGACCCTATCCTGAGAATGGGGTTTGAAAGGAAGGTGAGGGCTGTGGCCCCTGGACGGGTACAATAACA CACTGTACTGATGTCACAACTTTGCAAGCTCTGCCTTGGGTTCAGCCCATCTGGGCTCAAATTCCAGCCTCACCACTCACAAGCTGTGTG ACTTCAAACAAATGAAATCAGTGCCCAGAACCTCGGTTTCCTCATCTGTAATGTGGGGATCATAACACCTACCTCATGGAGTTGTGGTGA >In-frame_ENST00000508628_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(amino acids)=592AA_start in transcript=145_stop in transcript=1923 MECPSCQHVSKEETPKFCSQCGERLPPAAPIAAHAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQ RITRKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIFHD LFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDRTWTYSFSGAFLFSMGFLVAVLCYLSYR YVTKPPAPPNSLNVQRVLTFQPLRFIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPP PQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYAPQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQ KEPPAGSCMLGGLSLQEVTSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSP -------------------------------------------------------------- >In-frame_ENST00000456466_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(transcript)=2956nt_BP=240nt CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGCTCACGCCCCTGAGGACCCCTCGGATCTGC TCCAGCACGTGAAATTCCAGTCCAGCAACTTTGAAAACATCCTGACGTGGGACAGCGGGCCGGAGGGCACCCCAGACACGGTCTACAGCA TCGAGTATAAGACGTACGGAGAGAGGGACTGGGTGGCAAAGAAGGGCTGTCAGCGGATCACCCGGAAGTCCTGCAACCTGACGGTGGAGA CGGGCAACCTCACGGAGCTCTACTATGCCAGGGTCACCGCTGTCAGTGCGGGAGGCCGGTCAGCCACCAAGATGACTGACAGGTTCAGCT CTCTGCAGCACACTACCCTCAAGCCACCTGATGTGACCTGTATCTCCAAAGTGAGATCGATTCAGATGATTGTTCATCCTACCCCCACGC CAATCCGTGCAGGCGATGGCCACCGGCTAACCCTGGAAGACATCTTCCATGACCTGTTCTACCACTTAGAGCTCCAGGTCAACCGCACCT ACCAAATGCACCTTGGAGGGAAGCAGAGAGAATATGAGTTCTTCGGCCTGACCCCTGACACAGAGTTCCTTGGCACCATCATGATTTGCG TTCCCACCTGGGCCAAGGAGAGTGCCCCCTACATGTGCCGAGTGAAGACACTGCCAGACCGGACATGGACCTACTCCTTCTCCGGAGCCT TCCTGTTCTCCATGGGCTTCCTCGTCGCAGTACTCTGCTACCTGAGCTACAGATATGTCACCAAGCCGCCTGCACCTCCCAACTCCCTGA ACGTCCAGCGAGTCCTGACTTTCCAGCCGCTGCGCTTCATCCAGGAGCACGTCCTGATCCCTGTCTTTGACCTCAGCGGCCCCAGCAGTC TGGCCCAGCCTGTCCAGTACTCCCAGATCAGGGTGTCTGGACCCAGGGAGCCCGCAGGAGCTCCACAGCGGCATAGCCTGTCCGAGATCA CCTACTTAGGGCAGCCAGACATCTCCATCCTCCAGCCCTCCAACGTGCCACCTCCCCAGATCCTCTCCCCACTGTCCTATGCCCCAAACG CTGCCCCTGAGGTCGGGCCCCCATCCTATGCACCTCAGGTGACCCCCGAAGCTCAATTCCCATTCTACGCCCCACAGGCCATCTCTAAGG TCCAGCCTTCCTCCTATGCCCCTCAAGCCACTCCGGACAGCTGGCCTCCCTCCTATGGGGTATGCATGGAAGGTTCTGGCAAAGACTCCC CCACTGGGACACTTTCTAGTCCTAAACACCTTAGGCCTAAAGGTCAGCTTCAGAAAGAGCCACCAGCTGGAAGCTGCATGTTAGGTGGCC TTTCTCTGCAGGAGGTGACCTCCTTGGCTATGGAGGAATCCCAAGAAGCAAAATCATTGCACCAGCCCCTGGGGATTTGCACAGACAGAA CATCTGACCCAAATGTGCTACACAGTGGGGAGGAAGGGACACCACAGTACCTAAAGGGCCAGCTCCCCCTCCTCTCCTCAGTCCAGATCG AGGGCCACCCCATGTCCCTCCCTTTGCAACCTCCTTCCCGTCCATGTTCCCCCTCGGACCAAGGTCCAAGTCCCTGGGGCCTGCTGGAGT CCCTTGTGTGTCCCAAGGATGAAGCCAAGAGCCCAGCCCCTGAGACCTCAGACCTGGAGCAGCCCACAGAACTGGATTCTCTTTTCAGAG GCCTGGCCCTGACTGTGCAGTGGGAGTCCTGAGGGGAATGGGAAAGGCTTGGTGCTTCCTCCCTGTCCCTACCCAGTGTCACATCCTTGG CTGTCAATCCCATGCCTGCCCACGCCACACACTCTGCGATCTGGCCTCAGACGGGTGCCCTTGAGAGAAGCAGAGGGAGTGGCATGCAGG GCCCCTGCCATGGGTGCGCTCCTCACCGGAGCAAAGCAGCATGATAAGGACTGCAGCGGGGGAGCTCTGGGGAGCAGCTTGTGTAGACAA GCGCGTGCTCGCTGAGCCCTGCAAGGCAGAAATGACAGTGCAAGGAGGAAATGCAGGGAAACTCCCGAGGTCCAGAGCCCCACCTCCTAA CACCATGGATTCAAAGTGCTCAGGGAATTTGCCTCTCCTTGCCCCATTCCTGGCCAGTTTCACAATCTAGCTCGACAGAGCATGAGGCCC CTGCCTCTTCTGTCATTGTTCAAAGGTGGGAAGAGAGCCTGGAAAAGAACCAGGCCTGGAAAAGAACCAGAAGGAGGCTGGGCAGAACCA GAACAACCTGCACTTCTGCCAAGGCCAGGGCCAGCAGGACGGCAGGACTCTAGGGAGGGGTGTGGCCTGCAGCTCATTCCCAGCCAGGGC AACTGCCTGACGTTGCACGATTTCAGCTTCATTCCTCTGATAGAACAAAGCGAAATGCAGGTCCACCAGGGAGGGAGACACACAAGCCTT TTCTGCAGGCAGGAGTTTCAGACCCTATCCTGAGAATGGGGTTTGAAAGGAAGGTGAGGGCTGTGGCCCCTGGACGGGTACAATAACACA CTGTACTGATGTCACAACTTTGCAAGCTCTGCCTTGGGTTCAGCCCATCTGGGCTCAAATTCCAGCCTCACCACTCACAAGCTGTGTGAC TTCAAACAAATGAAATCAGTGCCCAGAACCTCGGTTTCCTCATCTGTAATGTGGGGATCATAACACCTACCTCATGGAGTTGTGGTGAAG >In-frame_ENST00000456466_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(amino acids)=592AA_start in transcript=143_stop in transcript=1921 MECPSCQHVSKEETPKFCSQCGERLPPAAPIAAHAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQ RITRKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIFHD LFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDRTWTYSFSGAFLFSMGFLVAVLCYLSYR YVTKPPAPPNSLNVQRVLTFQPLRFIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPP PQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYAPQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQ KEPPAGSCMLGGLSLQEVTSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSP -------------------------------------------------------------- >In-frame_ENST00000582970_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(transcript)=2956nt_BP=240nt CAGCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTG CCAGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGG AAACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGCTCACGCCCCTGAGGACCCCTCGGATCTGC TCCAGCACGTGAAATTCCAGTCCAGCAACTTTGAAAACATCCTGACGTGGGACAGCGGGCCGGAGGGCACCCCAGACACGGTCTACAGCA TCGAGTATAAGACGTACGGAGAGAGGGACTGGGTGGCAAAGAAGGGCTGTCAGCGGATCACCCGGAAGTCCTGCAACCTGACGGTGGAGA CGGGCAACCTCACGGAGCTCTACTATGCCAGGGTCACCGCTGTCAGTGCGGGAGGCCGGTCAGCCACCAAGATGACTGACAGGTTCAGCT CTCTGCAGCACACTACCCTCAAGCCACCTGATGTGACCTGTATCTCCAAAGTGAGATCGATTCAGATGATTGTTCATCCTACCCCCACGC CAATCCGTGCAGGCGATGGCCACCGGCTAACCCTGGAAGACATCTTCCATGACCTGTTCTACCACTTAGAGCTCCAGGTCAACCGCACCT ACCAAATGCACCTTGGAGGGAAGCAGAGAGAATATGAGTTCTTCGGCCTGACCCCTGACACAGAGTTCCTTGGCACCATCATGATTTGCG TTCCCACCTGGGCCAAGGAGAGTGCCCCCTACATGTGCCGAGTGAAGACACTGCCAGACCGGACATGGACCTACTCCTTCTCCGGAGCCT TCCTGTTCTCCATGGGCTTCCTCGTCGCAGTACTCTGCTACCTGAGCTACAGATATGTCACCAAGCCGCCTGCACCTCCCAACTCCCTGA ACGTCCAGCGAGTCCTGACTTTCCAGCCGCTGCGCTTCATCCAGGAGCACGTCCTGATCCCTGTCTTTGACCTCAGCGGCCCCAGCAGTC TGGCCCAGCCTGTCCAGTACTCCCAGATCAGGGTGTCTGGACCCAGGGAGCCCGCAGGAGCTCCACAGCGGCATAGCCTGTCCGAGATCA CCTACTTAGGGCAGCCAGACATCTCCATCCTCCAGCCCTCCAACGTGCCACCTCCCCAGATCCTCTCCCCACTGTCCTATGCCCCAAACG CTGCCCCTGAGGTCGGGCCCCCATCCTATGCACCTCAGGTGACCCCCGAAGCTCAATTCCCATTCTACGCCCCACAGGCCATCTCTAAGG TCCAGCCTTCCTCCTATGCCCCTCAAGCCACTCCGGACAGCTGGCCTCCCTCCTATGGGGTATGCATGGAAGGTTCTGGCAAAGACTCCC CCACTGGGACACTTTCTAGTCCTAAACACCTTAGGCCTAAAGGTCAGCTTCAGAAAGAGCCACCAGCTGGAAGCTGCATGTTAGGTGGCC TTTCTCTGCAGGAGGTGACCTCCTTGGCTATGGAGGAATCCCAAGAAGCAAAATCATTGCACCAGCCCCTGGGGATTTGCACAGACAGAA CATCTGACCCAAATGTGCTACACAGTGGGGAGGAAGGGACACCACAGTACCTAAAGGGCCAGCTCCCCCTCCTCTCCTCAGTCCAGATCG AGGGCCACCCCATGTCCCTCCCTTTGCAACCTCCTTCCCGTCCATGTTCCCCCTCGGACCAAGGTCCAAGTCCCTGGGGCCTGCTGGAGT CCCTTGTGTGTCCCAAGGATGAAGCCAAGAGCCCAGCCCCTGAGACCTCAGACCTGGAGCAGCCCACAGAACTGGATTCTCTTTTCAGAG GCCTGGCCCTGACTGTGCAGTGGGAGTCCTGAGGGGAATGGGAAAGGCTTGGTGCTTCCTCCCTGTCCCTACCCAGTGTCACATCCTTGG CTGTCAATCCCATGCCTGCCCACGCCACACACTCTGCGATCTGGCCTCAGACGGGTGCCCTTGAGAGAAGCAGAGGGAGTGGCATGCAGG GCCCCTGCCATGGGTGCGCTCCTCACCGGAGCAAAGCAGCATGATAAGGACTGCAGCGGGGGAGCTCTGGGGAGCAGCTTGTGTAGACAA GCGCGTGCTCGCTGAGCCCTGCAAGGCAGAAATGACAGTGCAAGGAGGAAATGCAGGGAAACTCCCGAGGTCCAGAGCCCCACCTCCTAA CACCATGGATTCAAAGTGCTCAGGGAATTTGCCTCTCCTTGCCCCATTCCTGGCCAGTTTCACAATCTAGCTCGACAGAGCATGAGGCCC CTGCCTCTTCTGTCATTGTTCAAAGGTGGGAAGAGAGCCTGGAAAAGAACCAGGCCTGGAAAAGAACCAGAAGGAGGCTGGGCAGAACCA GAACAACCTGCACTTCTGCCAAGGCCAGGGCCAGCAGGACGGCAGGACTCTAGGGAGGGGTGTGGCCTGCAGCTCATTCCCAGCCAGGGC AACTGCCTGACGTTGCACGATTTCAGCTTCATTCCTCTGATAGAACAAAGCGAAATGCAGGTCCACCAGGGAGGGAGACACACAAGCCTT TTCTGCAGGCAGGAGTTTCAGACCCTATCCTGAGAATGGGGTTTGAAAGGAAGGTGAGGGCTGTGGCCCCTGGACGGGTACAATAACACA CTGTACTGATGTCACAACTTTGCAAGCTCTGCCTTGGGTTCAGCCCATCTGGGCTCAAATTCCAGCCTCACCACTCACAAGCTGTGTGAC TTCAAACAAATGAAATCAGTGCCCAGAACCTCGGTTTCCTCATCTGTAATGTGGGGATCATAACACCTACCTCATGGAGTTGTGGTGAAG >In-frame_ENST00000582970_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(amino acids)=592AA_start in transcript=143_stop in transcript=1921 MECPSCQHVSKEETPKFCSQCGERLPPAAPIAAHAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQ RITRKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIFHD LFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDRTWTYSFSGAFLFSMGFLVAVLCYLSYR YVTKPPAPPNSLNVQRVLTFQPLRFIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPP PQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYAPQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQ KEPPAGSCMLGGLSLQEVTSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSP -------------------------------------------------------------- >In-frame_ENST00000319921_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(transcript)=2954nt_BP=238nt GCGCGCGGCAGGCGGCGAGCTCGGGGGCCGCAGAAAATGAAACTGAAGCCGTGGTCACGTGACAGGACATGTAGTATATAGCAGGCTGCC AGCGACTCCTGCTCTTGCTTCTGGATCTGCAGGGCAGTCCCAGCAGGACCCATGGAGTGTCCTTCGTGCCAGCATGTCTCCAAGGAGGAA ACCCCCAAGTTCTGCAGCCAGTGCGGAGAGAGGCTGCCTCCTGCAGCCCCCATAGCAGCTCACGCCCCTGAGGACCCCTCGGATCTGCTC CAGCACGTGAAATTCCAGTCCAGCAACTTTGAAAACATCCTGACGTGGGACAGCGGGCCGGAGGGCACCCCAGACACGGTCTACAGCATC GAGTATAAGACGTACGGAGAGAGGGACTGGGTGGCAAAGAAGGGCTGTCAGCGGATCACCCGGAAGTCCTGCAACCTGACGGTGGAGACG GGCAACCTCACGGAGCTCTACTATGCCAGGGTCACCGCTGTCAGTGCGGGAGGCCGGTCAGCCACCAAGATGACTGACAGGTTCAGCTCT CTGCAGCACACTACCCTCAAGCCACCTGATGTGACCTGTATCTCCAAAGTGAGATCGATTCAGATGATTGTTCATCCTACCCCCACGCCA ATCCGTGCAGGCGATGGCCACCGGCTAACCCTGGAAGACATCTTCCATGACCTGTTCTACCACTTAGAGCTCCAGGTCAACCGCACCTAC CAAATGCACCTTGGAGGGAAGCAGAGAGAATATGAGTTCTTCGGCCTGACCCCTGACACAGAGTTCCTTGGCACCATCATGATTTGCGTT CCCACCTGGGCCAAGGAGAGTGCCCCCTACATGTGCCGAGTGAAGACACTGCCAGACCGGACATGGACCTACTCCTTCTCCGGAGCCTTC CTGTTCTCCATGGGCTTCCTCGTCGCAGTACTCTGCTACCTGAGCTACAGATATGTCACCAAGCCGCCTGCACCTCCCAACTCCCTGAAC GTCCAGCGAGTCCTGACTTTCCAGCCGCTGCGCTTCATCCAGGAGCACGTCCTGATCCCTGTCTTTGACCTCAGCGGCCCCAGCAGTCTG GCCCAGCCTGTCCAGTACTCCCAGATCAGGGTGTCTGGACCCAGGGAGCCCGCAGGAGCTCCACAGCGGCATAGCCTGTCCGAGATCACC TACTTAGGGCAGCCAGACATCTCCATCCTCCAGCCCTCCAACGTGCCACCTCCCCAGATCCTCTCCCCACTGTCCTATGCCCCAAACGCT GCCCCTGAGGTCGGGCCCCCATCCTATGCACCTCAGGTGACCCCCGAAGCTCAATTCCCATTCTACGCCCCACAGGCCATCTCTAAGGTC CAGCCTTCCTCCTATGCCCCTCAAGCCACTCCGGACAGCTGGCCTCCCTCCTATGGGGTATGCATGGAAGGTTCTGGCAAAGACTCCCCC ACTGGGACACTTTCTAGTCCTAAACACCTTAGGCCTAAAGGTCAGCTTCAGAAAGAGCCACCAGCTGGAAGCTGCATGTTAGGTGGCCTT TCTCTGCAGGAGGTGACCTCCTTGGCTATGGAGGAATCCCAAGAAGCAAAATCATTGCACCAGCCCCTGGGGATTTGCACAGACAGAACA TCTGACCCAAATGTGCTACACAGTGGGGAGGAAGGGACACCACAGTACCTAAAGGGCCAGCTCCCCCTCCTCTCCTCAGTCCAGATCGAG GGCCACCCCATGTCCCTCCCTTTGCAACCTCCTTCCCGTCCATGTTCCCCCTCGGACCAAGGTCCAAGTCCCTGGGGCCTGCTGGAGTCC CTTGTGTGTCCCAAGGATGAAGCCAAGAGCCCAGCCCCTGAGACCTCAGACCTGGAGCAGCCCACAGAACTGGATTCTCTTTTCAGAGGC CTGGCCCTGACTGTGCAGTGGGAGTCCTGAGGGGAATGGGAAAGGCTTGGTGCTTCCTCCCTGTCCCTACCCAGTGTCACATCCTTGGCT GTCAATCCCATGCCTGCCCACGCCACACACTCTGCGATCTGGCCTCAGACGGGTGCCCTTGAGAGAAGCAGAGGGAGTGGCATGCAGGGC CCCTGCCATGGGTGCGCTCCTCACCGGAGCAAAGCAGCATGATAAGGACTGCAGCGGGGGAGCTCTGGGGAGCAGCTTGTGTAGACAAGC GCGTGCTCGCTGAGCCCTGCAAGGCAGAAATGACAGTGCAAGGAGGAAATGCAGGGAAACTCCCGAGGTCCAGAGCCCCACCTCCTAACA CCATGGATTCAAAGTGCTCAGGGAATTTGCCTCTCCTTGCCCCATTCCTGGCCAGTTTCACAATCTAGCTCGACAGAGCATGAGGCCCCT GCCTCTTCTGTCATTGTTCAAAGGTGGGAAGAGAGCCTGGAAAAGAACCAGGCCTGGAAAAGAACCAGAAGGAGGCTGGGCAGAACCAGA ACAACCTGCACTTCTGCCAAGGCCAGGGCCAGCAGGACGGCAGGACTCTAGGGAGGGGTGTGGCCTGCAGCTCATTCCCAGCCAGGGCAA CTGCCTGACGTTGCACGATTTCAGCTTCATTCCTCTGATAGAACAAAGCGAAATGCAGGTCCACCAGGGAGGGAGACACACAAGCCTTTT CTGCAGGCAGGAGTTTCAGACCCTATCCTGAGAATGGGGTTTGAAAGGAAGGTGAGGGCTGTGGCCCCTGGACGGGTACAATAACACACT GTACTGATGTCACAACTTTGCAAGCTCTGCCTTGGGTTCAGCCCATCTGGGCTCAAATTCCAGCCTCACCACTCACAAGCTGTGTGACTT CAAACAAATGAAATCAGTGCCCAGAACCTCGGTTTCCTCATCTGTAATGTGGGGATCATAACACCTACCTCATGGAGTTGTGGTGAAGAT >In-frame_ENST00000319921_ENST00000270800_TCGA-GV-A3JZ-01A_RNF213_chr17_78237577_+_IL22RA1_chr1_24465204_length(amino acids)=592AA_start in transcript=141_stop in transcript=1919 MECPSCQHVSKEETPKFCSQCGERLPPAAPIAAHAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQ RITRKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIFHD LFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDRTWTYSFSGAFLFSMGFLVAVLCYLSYR YVTKPPAPPNSLNVQRVLTFQPLRFIQEHVLIPVFDLSGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPP PQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISKVQPSSYAPQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQ KEPPAGSCMLGGLSLQEVTSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RNF213-IL22RA1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RNF213-IL22RA1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RNF213-IL22RA1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RNF213 | C1846689 | MOYAMOYA DISEASE 2 | 9 | CTD_human;UNIPROT |
Hgene | RNF213 | C0026654 | Moyamoya Disease | 3 | ORPHANET |
Hgene | RNF213 | C2931384 | Moyamoya disease 1 | 3 | ORPHANET |