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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF214-AKR1A1 (FusionGDB2 ID:74536)

Fusion Gene Summary for RNF214-AKR1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF214-AKR1A1
Fusion gene ID: 74536
HgeneTgene
Gene symbol

RNF214

AKR1A1

Gene ID

257160

10327

Gene namering finger protein 214aldo-keto reductase family 1 member A1
Synonyms-ALDR1|ALR|ARM|DD3|HEL-S-6
Cytomap

11q23.3

1p34.1

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 214aldo-keto reductase family 1 member A1HEL-S-165mPalcohol dehydrogenasealdehyde reductasedihydrodiol dehydrogenase 3epididymis secretory protein Li 6epididymis secretory sperm binding protein Li 165mPglucuronate reductaseglucuronolactone reductase
Modification date2020031320200313
UniProtAcc.

P14550

Ensembl transtripts involved in fusion geneENST00000531287, ENST00000531452, 
ENST00000530849, ENST00000300650, 
ENST00000524917, 		ENST00000372070, 
ENST00000351829, ENST00000471651, 
ENST00000473038, 
Fusion gene scores* DoF score7 X 5 X 6=2103 X 3 X 3=27
# samples 93
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNF214 [Title/Abstract] AND AKR1A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF214(117105095)-AKR1A1(46033654), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAKR1A1

GO:0044597

daunorubicin metabolic process

18276838

TgeneAKR1A1

GO:0044598

doxorubicin metabolic process

18276838


check buttonFusion gene breakpoints across RNF214 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AKR1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5734-11ARNF214chr11

117105095

+AKR1A1chr1

46033654

+


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Fusion Gene ORF analysis for RNF214-AKR1A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000531287ENST00000372070RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000531287ENST00000351829RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-intronENST00000531287ENST00000471651RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-3UTRENST00000531287ENST00000473038RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000531452ENST00000372070RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000531452ENST00000351829RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-intronENST00000531452ENST00000471651RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-3UTRENST00000531452ENST00000473038RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000530849ENST00000372070RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000530849ENST00000351829RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-intronENST00000530849ENST00000471651RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-3UTRENST00000530849ENST00000473038RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000300650ENST00000372070RNF214chr11

117105095

+AKR1A1chr1

46033654

+
In-frameENST00000300650ENST00000351829RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-intronENST00000300650ENST00000471651RNF214chr11

117105095

+AKR1A1chr1

46033654

+
5CDS-3UTRENST00000300650ENST00000473038RNF214chr11

117105095

+AKR1A1chr1

46033654

+
intron-3CDSENST00000524917ENST00000372070RNF214chr11

117105095

+AKR1A1chr1

46033654

+
intron-3CDSENST00000524917ENST00000351829RNF214chr11

117105095

+AKR1A1chr1

46033654

+
intron-intronENST00000524917ENST00000471651RNF214chr11

117105095

+AKR1A1chr1

46033654

+
intron-3UTRENST00000524917ENST00000473038RNF214chr11

117105095

+AKR1A1chr1

46033654

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000531287RNF214chr11117105095+ENST00000372070AKR1A1chr146033654+86815346774242
ENST00000531287RNF214chr11117105095+ENST00000351829AKR1A1chr146033654+86815346774242
ENST00000531452RNF214chr11117105095+ENST00000372070AKR1A1chr146033654+86815346774242
ENST00000531452RNF214chr11117105095+ENST00000351829AKR1A1chr146033654+86815346774242
ENST00000530849RNF214chr11117105095+ENST00000372070AKR1A1chr146033654+83211710738242
ENST00000530849RNF214chr11117105095+ENST00000351829AKR1A1chr146033654+83211710738242
ENST00000300650RNF214chr11117105095+ENST00000372070AKR1A1chr146033654+8311169737242
ENST00000300650RNF214chr11117105095+ENST00000351829AKR1A1chr146033654+8311169737242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531287ENST00000372070RNF214chr11117105095+AKR1A1chr146033654+0.0047113320.9952886
ENST00000531287ENST00000351829RNF214chr11117105095+AKR1A1chr146033654+0.0047113320.9952886
ENST00000531452ENST00000372070RNF214chr11117105095+AKR1A1chr146033654+0.0047113320.9952886
ENST00000531452ENST00000351829RNF214chr11117105095+AKR1A1chr146033654+0.0047113320.9952886
ENST00000530849ENST00000372070RNF214chr11117105095+AKR1A1chr146033654+0.0044839280.9955161
ENST00000530849ENST00000351829RNF214chr11117105095+AKR1A1chr146033654+0.0044839280.9955161
ENST00000300650ENST00000372070RNF214chr11117105095+AKR1A1chr146033654+0.0043665370.9956334
ENST00000300650ENST00000351829RNF214chr11117105095+AKR1A1chr146033654+0.0043665370.9956334

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Fusion Genomic Features for RNF214-AKR1A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF214chr11117105095+AKR1A1chr146033653+2.76E-050.99997246
RNF214chr11117105095+AKR1A1chr146033653+2.76E-050.99997246

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF214-AKR1A1


check button Go to

FGviewer for the breakpoints of chr11:117105095-chr1:46033654

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AKR1A1

P14550

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:11306097, ECO:0000269|PubMed:18276838}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKR1A1chr11:117105095chr1:46033654ENST0000035182939162_163118.66666666666667326.0Nucleotide bindingNADP
TgeneAKR1A1chr11:117105095chr1:46033654ENST0000035182939210_217118.66666666666667326.0Nucleotide bindingNADP
TgeneAKR1A1chr11:117105095chr1:46033654ENST0000035182939261_273118.66666666666667326.0Nucleotide bindingNADP
TgeneAKR1A1chr11:117105095chr1:46033654ENST00000372070410162_163118.66666666666667326.0Nucleotide bindingNADP
TgeneAKR1A1chr11:117105095chr1:46033654ENST00000372070410210_217118.66666666666667326.0Nucleotide bindingNADP
TgeneAKR1A1chr11:117105095chr1:46033654ENST00000372070410261_273118.66666666666667326.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF214chr11:117105095chr1:46033654ENST00000300650+114220_37935.666666666666664704.0Coiled coilOntology_term=ECO:0000255
HgeneRNF214chr11:117105095chr1:46033654ENST00000531452+215220_37935.666666666666664704.0Coiled coilOntology_term=ECO:0000255
HgeneRNF214chr11:117105095chr1:46033654ENST00000300650+114432_55135.666666666666664704.0Compositional biasNote=Pro-rich
HgeneRNF214chr11:117105095chr1:46033654ENST00000531452+215432_55135.666666666666664704.0Compositional biasNote=Pro-rich
HgeneRNF214chr11:117105095chr1:46033654ENST00000300650+114658_70035.666666666666664704.0Zinc fingerRING-type%3B atypical
HgeneRNF214chr11:117105095chr1:46033654ENST00000531452+215658_70035.666666666666664704.0Zinc fingerRING-type%3B atypical
TgeneAKR1A1chr11:117105095chr1:46033654ENST000003518293921_23118.66666666666667326.0Nucleotide bindingNADP
TgeneAKR1A1chr11:117105095chr1:46033654ENST0000037207041021_23118.66666666666667326.0Nucleotide bindingNADP


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Fusion Gene Sequence for RNF214-AKR1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000531287_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=868nt_BP=153nt
GTCCCTCCCCCACTTTCCTCCCGGGGGCGCGGCGCGGGAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAG
TCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATCAGACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAA
TGCTGATGGGACTATATGCTACGACTCCACCCACTACAAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGC
GCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCA
CCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGCCAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCG
TGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGAT
CTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGCATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGA
CTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAA
GAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCCTTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCA

>In-frame_ENST00000531287_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=46_stop in transcript=774
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000531287_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=868nt_BP=153nt
GTCCCTCCCCCACTTTCCTCCCGGGGGCGCGGCGCGGGAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAG
TCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATCAGACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAA
TGCTGATGGGACTATATGCTACGACTCCACCCACTACAAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGC
GCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCA
CCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGCCAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCG
TGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGAT
CTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGCATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGA
CTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAA
GAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCCTTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCA

>In-frame_ENST00000531287_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=46_stop in transcript=774
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000531452_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=868nt_BP=153nt
GTCCCTCCCCCACTTTCCTCCCGGGGGCGCGGCGCGGGAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAG
TCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATCAGACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAA
TGCTGATGGGACTATATGCTACGACTCCACCCACTACAAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGC
GCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCA
CCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGCCAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCG
TGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGAT
CTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGCATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGA
CTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAA
GAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCCTTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCA

>In-frame_ENST00000531452_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=46_stop in transcript=774
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000531452_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=868nt_BP=153nt
GTCCCTCCCCCACTTTCCTCCCGGGGGCGCGGCGCGGGAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAG
TCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATCAGACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAA
TGCTGATGGGACTATATGCTACGACTCCACCCACTACAAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGC
GCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCA
CCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGCCAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCG
TGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGAT
CTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGCATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGA
CTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAA
GAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCCTTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCA

>In-frame_ENST00000531452_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=46_stop in transcript=774
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000530849_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=832nt_BP=117nt
ACAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAGTCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATC
AGACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTA
CAAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGA
TGACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTG
CCAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGA
GGAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTG
CATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAA
TGCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCC
CTTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCAGCTAATGAGGTCCTGCCACAACGGAAAGAGGGAGTT

>In-frame_ENST00000530849_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=10_stop in transcript=738
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000530849_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=832nt_BP=117nt
ACAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAGTCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATC
AGACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTA
CAAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGA
TGACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTG
CCAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGA
GGAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTG
CATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAA
TGCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCC
CTTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCAGCTAATGAGGTCCTGCCACAACGGAAAGAGGGAGTT

>In-frame_ENST00000530849_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=10_stop in transcript=738
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000300650_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=831nt_BP=116nt
CAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAGTCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATCA
GACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC
AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGAT
GACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC
CAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGAG
GAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC
ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAAT
GCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC
TTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCAGCTAATGAGGTCCTGCCACAACGGAAAGAGGGAGTTA

>In-frame_ENST00000300650_ENST00000372070_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=9_stop in transcript=737
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------
>In-frame_ENST00000300650_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(transcript)=831nt_BP=116nt
CAGAGCATAATGGCAGCGTCTGAGGTTGCTGGTGTTGTGGCCAATGCCCCCAGTCCTCCGGAATCTTCTAGTTTATGTGCTTCCAAATCA
GACGAAGGTCTCCCAGATGGTCTAAGGCGGGGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC
AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGCCTGTCCAACTTCAACAGTCGGCAGATTGAT
GACATACTCAGTGTGGCCTCCGTGCGTCCAGCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC
CAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGGCGTGATCCTGATGAGCCTGTCCTGCTGGAG
GAACCAGTAGTCCTGGCATTGGCTGAAAAGTATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC
ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACCTTTAGCCCAGAAGAGATGAAGCAGCTAAAT
GCCCTGAACAAAAATTGGAGATATATTGTGCCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC
TTTAATGACCCGTACTGAGACCACAGCTTCTTGGCCTCCCTTCCAGCTCTGCAGCTAATGAGGTCCTGCCACAACGGAAAGAGGGAGTTA

>In-frame_ENST00000300650_ENST00000351829_TCGA-CG-5734-11A_RNF214_chr11_117105095_+_AKR1A1_chr1_46033654_length(amino acids)=242AA_start in transcript=9_stop in transcript=737
MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLRRGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDIL
SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF214-AKR1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF214-AKR1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAKR1A1P14550DB09130CopperSmall moleculeApproved|Investigational
TgeneAKR1A1P14550DB09130CopperSmall moleculeApproved|Investigational
TgeneAKR1A1P14550DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for RNF214-AKR1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAKR1A1C0001969Alcoholic Intoxication5PSYGENET
TgeneAKR1A1C0001973Alcoholic Intoxication, Chronic5PSYGENET
TgeneAKR1A1C0085762Alcohol abuse5PSYGENET
TgeneAKR1A1C0036341Schizophrenia1PSYGENET
TgeneAKR1A1C0520459Necrotizing Enterocolitis1CTD_human