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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF38-FLNB (FusionGDB2 ID:74605)

Fusion Gene Summary for RNF38-FLNB

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF38-FLNB
Fusion gene ID: 74605
HgeneTgene
Gene symbol

RNF38

FLNB

Gene ID

152006

2317

Gene namering finger protein 38filamin B
Synonyms-ABP-278|ABP-280|AOI|FH1|FLN-B|FLN1L|LRS1|SCT|TABP|TAP
Cytomap

9p13.2

3p14.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38filamin-BABP-280 homologLarsen syndrome 1 (autosomal dominant)actin binding protein 278actin-binding-like proteinbeta-filaminfilamin B, betafilamin homolog 1filamin-3thyroid autoantigen
Modification date2020031320200313
UniProtAcc.

O75369

Ensembl transtripts involved in fusion geneENST00000259605, ENST00000353739, 
ENST00000357058, ENST00000350199, 
ENST00000377885, ENST00000377877, 
ENST00000491349, 		ENST00000490882, 
ENST00000429972, ENST00000295956, 
ENST00000358537, ENST00000357272, 
ENST00000348383, ENST00000493452, 
ENST00000419752, ENST00000484981, 
Fusion gene scores* DoF score12 X 6 X 9=64819 X 22 X 8=3344
# samples 1323
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3344*10)=-3.86186908113651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF38 [Title/Abstract] AND FLNB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF38(36487305)-FLNB(58062773), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF38

GO:0016567

protein ubiquitination

23973461


check buttonFusion gene breakpoints across RNF38 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FLNB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01ARNF38chr9

36487305

-FLNBchr3

58062773

+


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Fusion Gene ORF analysis for RNF38-FLNB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000259605ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000259605ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000259605ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000259605ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000259605ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000259605ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000259605ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000259605ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000259605ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000353739ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000353739ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000353739ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000353739ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000353739ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000353739ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000353739ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000353739ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000353739ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000357058ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000357058ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000357058ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000357058ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000357058ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000357058ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000357058ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000357058ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000357058ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000350199ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000350199ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000350199ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000350199ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000350199ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000350199ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000350199ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000350199ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000350199ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377885ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377885ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377885ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377885ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377885ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377885ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000377885ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000377885ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000377885ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377877ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377877ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377877ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377877ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377877ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000377877ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000377877ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000377877ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000377877ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000491349ENST00000490882RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000491349ENST00000429972RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000491349ENST00000295956RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000491349ENST00000358537RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000491349ENST00000357272RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-3CDSENST00000491349ENST00000348383RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000491349ENST00000493452RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000491349ENST00000419752RNF38chr9

36487305

-FLNBchr3

58062773

+
intron-intronENST00000491349ENST00000484981RNF38chr9

36487305

-FLNBchr3

58062773

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RNF38-FLNB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF38-FLNB


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FLNB

O75369

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RNF38-FLNB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RNF38-FLNB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF38-FLNB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF38-FLNB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFLNBC0175778Larsen syndrome2GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFLNBC0432201Boomerang dysplasia2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFLNBC0265283Atelosteogenesis, type 11CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFLNBC1848934SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME1CTD_human;GENOMICS_ENGLAND
TgeneFLNBC2931648Larsen syndrome, dominant type1CTD_human;ORPHANET
TgeneFLNBC3668942Atelosteogenesis Type 31CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT