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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF4-BTF3 (FusionGDB2 ID:74617)

Fusion Gene Summary for RNF4-BTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF4-BTF3
Fusion gene ID: 74617
HgeneTgene
Gene symbol

RNF4

BTF3

Gene ID

6047

10384

Gene namering finger protein 4butyrophilin subfamily 3 member A3
SynonymsRES4-26|SLX5|SNURFBTF3|BTN3.3
Cytomap

4p16.3

6p22.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF4E3 ubiquitin ligase RNF4RING-type E3 ubiquitin transferase RNF4small nuclear RING finger proteinbutyrophilin subfamily 3 member A3butyrophilin 3butyrophilin subfamily 3 member A3 secreted isoform
Modification date2020031320200313
UniProtAcc.

Q96K17

Ensembl transtripts involved in fusion geneENST00000314289, ENST00000541204, 
ENST00000509258, ENST00000511843, 
ENST00000511859, ENST00000506706, 
ENST00000511600, 		ENST00000335895, 
ENST00000514505, ENST00000380591, 
Fusion gene scores* DoF score9 X 9 X 7=5679 X 7 X 6=378
# samples 1411
** MAII scorelog2(14/567*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/378*10)=-1.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF4 [Title/Abstract] AND BTF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF4(2492229)-BTF3(72798313), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNF4

GO:0045944

positive regulation of transcription by RNA polymerase II

12885770

HgeneRNF4

GO:0046685

response to arsenic-containing substance

20943951


check buttonFusion gene breakpoints across RNF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8372-01ARNF4chr4

2492229

+BTF3chr5

72798313

+


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Fusion Gene ORF analysis for RNF4-BTF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314289ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000314289ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000314289ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+
In-frameENST00000541204ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000541204ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000541204ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+
In-frameENST00000509258ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000509258ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000509258ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+
intron-3CDSENST00000511843ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
intron-3UTRENST00000511843ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
intron-3UTRENST00000511843ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+
In-frameENST00000511859ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000511859ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000511859ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+
In-frameENST00000506706ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000506706ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000506706ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+
In-frameENST00000511600ENST00000335895RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000511600ENST00000514505RNF4chr4

2492229

+BTF3chr5

72798313

+
5CDS-3UTRENST00000511600ENST00000380591RNF4chr4

2492229

+BTF3chr5

72798313

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314289RNF4chr42492229+ENST00000335895BTF3chr572798313+1165488398907169
ENST00000541204RNF4chr42492229+ENST00000335895BTF3chr572798313+1022345255764169
ENST00000509258RNF4chr42492229+ENST00000335895BTF3chr572798313+996319229738169
ENST00000511859RNF4chr42492229+ENST00000335895BTF3chr572798313+962285195704169
ENST00000506706RNF4chr42492229+ENST00000335895BTF3chr572798313+15568797891298169
ENST00000511600RNF4chr42492229+ENST00000335895BTF3chr572798313+2201152421659212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314289ENST00000335895RNF4chr42492229+BTF3chr572798313+0.0028816950.99711835
ENST00000541204ENST00000335895RNF4chr42492229+BTF3chr572798313+0.0019664970.99803346
ENST00000509258ENST00000335895RNF4chr42492229+BTF3chr572798313+0.0029404520.9970595
ENST00000511859ENST00000335895RNF4chr42492229+BTF3chr572798313+0.0032838960.99671614
ENST00000506706ENST00000335895RNF4chr42492229+BTF3chr572798313+0.0035495970.9964504
ENST00000511600ENST00000335895RNF4chr42492229+BTF3chr572798313+0.440263120.55973685

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Fusion Genomic Features for RNF4-BTF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF4chr42492229+BTF3chr572798312+2.29E-060.99999774
RNF4chr42492229+BTF3chr572798312+2.29E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNF4-BTF3


check button Go to

FGviewer for the breakpoints of chr4:2492229-chr5:72798313

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BTF3

Q96K17

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBTF3chr4:2492229chr5:72798313ENST0000033589516185_18823.0163.0Compositional biasNote=Poly-Asp
TgeneBTF3chr4:2492229chr5:72798313ENST0000038059116185_18867.0207.0Compositional biasNote=Poly-Asp
TgeneBTF3chr4:2492229chr5:72798313ENST000003358951682_14723.0163.0DomainNAC-A/B
TgeneBTF3chr4:2492229chr5:72798313ENST000003805911682_14767.0207.0DomainNAC-A/B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF4chr4:2492229chr5:72798313ENST00000314289+281_163.0191.0RegionRequired for ubiquitination activity
HgeneRNF4chr4:2492229chr5:72798313ENST00000506706+391_163.0191.0RegionRequired for ubiquitination activity
HgeneRNF4chr4:2492229chr5:72798313ENST00000511600+281_163.0191.0RegionRequired for ubiquitination activity
HgeneRNF4chr4:2492229chr5:72798313ENST00000511859+271_163.0114.0RegionRequired for ubiquitination activity
HgeneRNF4chr4:2492229chr5:72798313ENST00000314289+28132_1773.0191.0Zinc fingerRING-type
HgeneRNF4chr4:2492229chr5:72798313ENST00000506706+39132_1773.0191.0Zinc fingerRING-type
HgeneRNF4chr4:2492229chr5:72798313ENST00000511600+28132_1773.0191.0Zinc fingerRING-type
HgeneRNF4chr4:2492229chr5:72798313ENST00000511859+27132_1773.0114.0Zinc fingerRING-type


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Fusion Gene Sequence for RNF4-BTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000314289_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(transcript)=1165nt_BP=488nt
AGTGCGCTCGATTGTGGGCGGGGGCGGAAAGAGGCGCGTTTTAAAGTGGTAACAGATGGTTTTCTTATCCAATAGGATTAAAAAATTTGT
CCTTACCCGGCCGACCGCGGAAGTAGAGTAGGCGGGCGGCCAATGGGGACATGATGGGGGGCGGAGCCGAGGCCTCCGAAGCGGAAGTGG
GTTGCTGTTGAGGCGGCGGCATCTTTCTCGAGGAGCTCTCCTGGGCGGCTGAAGAAGGAGCTTCTTCTCCGGAGTGCGCCGGCGGTGGCG
CCTGCGGACCTAACTAGCTCCAGGTTAGGCCGAGCTTTGCGGGAAAGCAGCGGACTTGAAAATACTGGAAATCTGTCCGGATCCAAATTA
TTTTGCAAGCCAGATGAGTAACCAGAGGGCATGAAAGGTTGAGAACATTTGACTTCCCTGCAAACCTTGGTATAGATCACTTCCTTTTCT
GTAGGAAAGGAAAGGCACCAAAGAGCACAATGAGTACAGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATG
ACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAG
TGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAG
AAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGG
ATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGG
CAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTT
TTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATAC

>In-frame_ENST00000314289_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(amino acids)=169AA_start in transcript=398_stop in transcript=907
MRTFDFPANLGIDHFLFCRKGKAPKSTMSTGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASL

--------------------------------------------------------------
>In-frame_ENST00000541204_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(transcript)=1022nt_BP=345nt
ATGGGGGGCGGAGCCGAGGCCTCCGAAGCGGAAGTGGGTTGCTGTTGAGGCGGCGGCATCTTTCTCGAGGAGCTCTCCTGGGCGGCTGAA
GAAGGAGCTTCTTCTCCGGAGTGCGCCGGCGGTGGCGCCTGCGGACCTAACTAGCTCCAGGTTAGGCCGAGCTTTGCGGGAAAGCAGCGG
ACTTGAAAATACTGGAAATCTGTCCGGATCCAAATTATTTTGCAAGCCAGATGAGTAACCAGAGGGCATGAAAGGTTGAGAACATTTGAC
TTCCCTGCAAACCTTGGTATAGATCACTTCCTTTTCTGTAGGAAAGGAAAGGCACCAAAGAGCACAATGAGTACAGGAACTGCTCGCAGA
AAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGT
ATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTC
ACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTA
AGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGAT
CTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAG
CTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCC
CTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTG

>In-frame_ENST00000541204_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(amino acids)=169AA_start in transcript=255_stop in transcript=764
MRTFDFPANLGIDHFLFCRKGKAPKSTMSTGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASL

--------------------------------------------------------------
>In-frame_ENST00000509258_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(transcript)=996nt_BP=319nt
AGCGGAAGTGGGTTGCTGTTGAGGCGGCGGCATCTTTCTCGAGGAGCTCTCCTGGGCGGCTGAAGAAGGAGCTTCTTCTCCGGAGTGCGC
CGGCGGTGGCGCCTGCGGACCTAACTAGCTCCAGGTTAGGCCGAGCTTTGCGGGAAAGCAGCGGACTTGAAAATACTGGAAATCTGTCCG
GATCCAAATTATTTTGCAAGCCAGATGAGTAACCAGAGGGCATGAAAGGTTGAGAACATTTGACTTCCCTGCAAACCTTGGTATAGATCA
CTTCCTTTTCTGTAGGAAAGGAAAGGCACCAAAGAGCACAATGAGTACAGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGC
CACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAA
CCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAA
GCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAA
ACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTC
CAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTT
TTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTT
TTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAAAGATTAATAAAGTTCTTTGC

>In-frame_ENST00000509258_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(amino acids)=169AA_start in transcript=229_stop in transcript=738
MRTFDFPANLGIDHFLFCRKGKAPKSTMSTGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASL

--------------------------------------------------------------
>In-frame_ENST00000511859_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(transcript)=962nt_BP=285nt
TTTCTCGAGGAGCTCTCCTGGGCGGCTGAAGAAGGAGCTTCTTCTCCGGAGTGCGCCGGCGGTGGCGCCTGCGGACCTAACTAGCTCCAG
GTTAGGCCGAGCTTTGCGGGAAAGCAGCGGACTTGAAAATACTGGAAATCTGTCCGGATCCAAATTATTTTGCAAGCCAGATGAGTAACC
AGAGGGCATGAAAGGTTGAGAACATTTGACTTCCCTGCAAACCTTGGTATAGATCACTTCCTTTTCTGTAGGAAAGGAAAGGCACCAAAG
AGCACAATGAGTACAGGAACTGCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTA
AAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAA
GTTCAGGCATCTCTGGCAGCGAACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAAC
CAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACT
GGAGAGGATGATGATGATGAAGTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCT
GAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATC
TAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAAT

>In-frame_ENST00000511859_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(amino acids)=169AA_start in transcript=195_stop in transcript=704
MRTFDFPANLGIDHFLFCRKGKAPKSTMSTGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASL

--------------------------------------------------------------
>In-frame_ENST00000506706_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(transcript)=1556nt_BP=879nt
AGAAGTTAGGAGGTCTGCGTCTGGGTCTCGGCTCACCCTGGGGGGCCGCGGCCATGGGGCTTAGTTCCTAGCCTAGGAAGGGAAACTGAG
ACTCTGGGAGGGGCAGGAACGCCCCCAAGGTCACTTGGAAAGTCGGGCAGGATGTGCTGTTAGGGGGAAGACCCGGGCAGGGTTTTTGTT
CCCCGCTGACGACGCCTCCTTTGTGTGTTCGCGCCGCCGCCCCGCCATCGTGGGGCCTGCGAGTTTGCCGGGGTGCGTGGGCCGCGTGGC
GGGGCCTTTTGTAGGTCGGGAGGATCTGAGTACGGGTGCGGGCCTGACCGTGGGGGCGCCGAGGTCGCAGTCTAAAACTTAGTAGGGCCT
CGATTTCCGGGCGCGCTTCCGGGCCCCGGCTGGTGGTTGGTGGAACGTGCGACTGTGAGGCTTGCGGCCCAGCCCTGCACCGCTCGGGCC
CTTCACCGCTCTGGCGCGCCTATAGACAGGTGTATGAAGATTCTCACGACCCGAAACAGAGTTGCTAGTAAACACCGCTTTTCCGCCTTT
GATCCATCGAGGGAAGAGGGAAAAGGATAGAGCTTGGGCAAGCCGTTTTGGTGGAATCTCACTCTGTCACCCAGGATGCAGTGCACTGGC
GTGTTCTCGGTCTCACTGTAACCTCTGCCATCTGGGCTCAAGTGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGACTTGA
AAATACTGGAAATCTGTCCGGATCCAAATTATTTTGCAAGCCAGATGAGTAACCAGAGGGCATGAAAGGTTGAGAACATTTGACTTCCCT
GCAAACCTTGGTATAGATCACTTCCTTTTCTGTAGGAAAGGAAAGGCACCAAAGAGCACAATGAGTACAGGAACTGCTCGCAGAAAGAAG
AAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAATATCTCTGGTATTGAA
GAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCGAACACTTTCACCATT
ACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTGACTAGTTTAAGGAGA
CTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAAGTTCCAGATCTTGTG
GAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGTTACTGGGAGCTGCTA
TTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAGCCCAAGCCCCTTGGA
CACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAATCAAGTTTGAAACAA

>In-frame_ENST00000506706_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(amino acids)=169AA_start in transcript=789_stop in transcript=1298
MRTFDFPANLGIDHFLFCRKGKAPKSTMSTGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASL

--------------------------------------------------------------
>In-frame_ENST00000511600_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(transcript)=2201nt_BP=1524nt
TTTTTCTCTTTCAAAAACACTCTGCCATCTTTTCAAGGTATCCGCCATCTCTTTCAAGCATGTGAGGAGCTTGATAACTTTTGTTGGGGG
TCGGTGTTCAGAATGACAAGGGTCTTGCCCAGGCTGGAGTGCAGTAGCACAGTCATAACTCACTCTAGCCTCAACCTCCCAGGGCACAAG
CGATCCTCCCATCTTAGCCTCCTGAGTAACTGGGACTACAGGCACGTGCCACCACACCCTGCTAATTTTTTTTTTTCTTTGGTATTAATA
TTTTGTAGAGAAGGAGTTTCACCATGTTGCCCAGGCTGGTCCAGAACTCCTGGGCTCAAGCAATCCTGCCTTGGCTTCCCAAAGTGCTGG
GATTACAGGCATGAGCCACCATGCCTGGCCCTAGAGCTTGATAATTTCATTCATTCATTCTTTTTTTTTTTTTTTTTTGAGACAAAGTCT
CAGTCTGTCACCCAGGTTGGAGTGCAATGGCGCAATCTTGGCTCACTGCAACTTCTGCCTCCCGAGTTCAAGGGGTTCTCCTGCCTCAGC
CTCCTGAGTGGCAGGGATTACAGATGCCCACCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGGTGGGGTTTCACCATGTTGGCCA
GGTTGGTCTCAAACTCCCAACCTCAGGTAATCTGCCCACCTTGGCCTCCCAGAGTGCTGGGATTACAGGTGTGAGCTCAGACCTTGATAA
TTTCAGTGAGGAAAAAAAAAAAATCTCATTTACATGTTTGTGCCAAGTGCTGTGCTAGTGGGTGGGGACACCATGATAAGTATTTGATAA
GTTATGTTTCTTGATTTAAGGGAGTATAGAAGAAATGGTTAAGTCAGGACTAGGAGGAGTGAGAGAAATGGAAGCAACCTTTGAGGTAGG
CCCTGAAGAACGAGCAGAAATTCCCTAAAGCGGGGTGGGAGCGGCAGGACCAACCTGGCCAACTTCGGACCTTCTTTGAGGTCCAAAGTC
AGGTACTTTGAACTGACTTCCAGGATACCTGGAGTAAAGTACAGTTCTGTTTGAAGTGTTTGTTTGGAAAGATGAGTTTGTTCCAGTGAG
GTTGCTGTATTAGAGAACCACTTGAGAGTTTGCTGCCCACAGTGTCATCTGTGAGAAATATTAGGTGAACGCAAAAAGTTGAGGCCAGCT
GAACCAAGCCATGTAATATACACACCTTCCACATAGATCAGTCACCTCAGTTGACTTGTATGTGAGCCACATTTGTGTCCATCTGATGTT
ACAGCATTCACTCTCTTTGCCTCCACTTCTCAATAACTCACAATCTGTAAACTGACTGAGGCCCGCTTCCACAGAGCAAGCTTCAGGCCT
TTTTCAAGGACTTGAAAATACTGGAAATCTGTCCGGATCCAAATTATTTTGCAAGCCAGATGAGTAACCAGAGGGCATGAAAGGTTGAGA
ACATTTGACTTCCCTGCAAACCTTGGTATAGATCACTTCCTTTTCTGTAGGAAAGGAAAGGCACCAAAGAGCACAATGAGTACAGGAACT
GCTCGCAGAAAGAAGAAGGTGGTTCATAGAACAGCCACAGCAGATGACAAAAAACTTCAGTTCTCCTTAAAGAAGTTAGGGGTAAACAAT
ATCTCTGGTATTGAAGAGGTGAATATGTTTACAAACCAAGGAACAGTGATCCACTTTAACAACCCTAAAGTTCAGGCATCTCTGGCAGCG
AACACTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGACAGAAATGCTACCCAGCATCTTAAACCAGCTTGGTGCGGATAGTCTG
ACTAGTTTAAGGAGACTGGCCGAAGCTCTGCCCAAACAATCTGTGGATGGAAAAGCACCACTTGCTACTGGAGAGGATGATGATGATGAA
GTTCCAGATCTTGTGGAGAATTTTGATGAGGCTTCCAAGAATGAGGCAAACTGAATTGAGTCAACTTCTGAAGATAAAACCTGAAGAAGT
TACTGGGAGCTGCTATTTTATATTATGACTGCTTTTTAAGAAATTTTTGTTTATGGATCTGATAAAATCTAGATCTCTAATATTTTTAAG
CCCAAGCCCCTTGGACACTGCAGCTCTTTTCAGTTTTTGCTTATACACAATTCATTCTTTGCAGCTAATTAAGCCGAAGAAGCCTGGGAA

>In-frame_ENST00000511600_ENST00000335895_TCGA-BR-8372-01A_RNF4_chr4_2492229_+_BTF3_chr5_72798313_length(amino acids)=212AA_start in transcript=21_stop in transcript=659
MPSFQGIRHLFQACEELDNFCWGSVFRMTRVLPRLECSSTVITHSSLNLPGHKRSSHLSLLSNWDYRHVPPHPANFFFSLVLIFCREGVS
PCCPGWSRTPGLKQSCLGFPKCWDYRHEPPCLALELDNFIHSFFFFFFFETKSQSVTQVGVQWRNLGSLQLLPPEFKGFSCLSLLSGRDY

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Fusion Gene PPI Analysis for RNF4-BTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF4-BTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF4-BTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource