FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RNGTT-TBC1D32 (FusionGDB2 ID:74690)

Fusion Gene Summary for RNGTT-TBC1D32

check button Fusion gene summary
Fusion gene informationFusion gene name: RNGTT-TBC1D32
Fusion gene ID: 74690
HgeneTgene
Gene symbol

RNGTT

TBC1D32

Gene ID

8732

221322

Gene nameRNA guanylyltransferase and 5'-phosphataseTBC1 domain family member 32
SynonymsCAP1A|HCE|HCE1|hCAPBROMI|C6orf170|C6orf171
Cytomap

6q15

6q22.31

Type of geneprotein-codingprotein-coding
DescriptionmRNA-capping enzymeHCAP1protein broad-mindedbroad-minded homolog
Modification date2020031320200313
UniProtAcc.

Q96NH3

Ensembl transtripts involved in fusion geneENST00000369485, ENST00000265607, 
ENST00000538899, ENST00000369475, 
ENST00000275159, ENST00000398212, 
ENST00000398197, 
Fusion gene scores* DoF score14 X 13 X 5=9103 X 3 X 2=18
# samples 153
** MAII scorelog2(15/910*10)=-2.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RNGTT [Title/Abstract] AND TBC1D32 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNGTT(89388072)-TBC1D32(121642940), # samples:2
Anticipated loss of major functional domain due to fusion event.RNGTT-TBC1D32 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRNGTT

GO:0006370

7-methylguanosine mRNA capping

9473487

HgeneRNGTT

GO:0006396

RNA processing

21636784


check buttonFusion gene breakpoints across RNGTT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TBC1D32 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UVMTCGA-VD-A8KJ-01ARNGTTchr6

89388072

-TBC1D32chr6

121642940

-
ChimerDB4UVMTCGA-VD-A8KJRNGTTchr6

89388072

-TBC1D32chr6

121642940

-


Top

Fusion Gene ORF analysis for RNGTT-TBC1D32

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369485ENST00000275159RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
Frame-shiftENST00000369485ENST00000398212RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
5CDS-intronENST00000369485ENST00000398197RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
Frame-shiftENST00000265607ENST00000275159RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
Frame-shiftENST00000265607ENST00000398212RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
5CDS-intronENST00000265607ENST00000398197RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
In-frameENST00000538899ENST00000275159RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
In-frameENST00000538899ENST00000398212RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
5CDS-intronENST00000538899ENST00000398197RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
intron-3CDSENST00000369475ENST00000275159RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
intron-3CDSENST00000369475ENST00000398212RNGTTchr6

89388072

-TBC1D32chr6

121642940

-
intron-intronENST00000369475ENST00000398197RNGTTchr6

89388072

-TBC1D32chr6

121642940

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538899RNGTTchr689388072-ENST00000275159TBC1D32chr6121642940-58121536148352771264
ENST00000538899RNGTTchr689388072-ENST00000398212TBC1D32chr6121642940-51551536148351541224

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538899ENST00000275159RNGTTchr689388072-TBC1D32chr6121642940-0.0005475540.9994524
ENST00000538899ENST00000398212RNGTTchr689388072-TBC1D32chr6121642940-0.0009243890.99907553

Top

Fusion Genomic Features for RNGTT-TBC1D32


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RNGTT-TBC1D32


check button Go to

FGviewer for the breakpoints of chr6:89388072-chr6:121642940

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TBC1D32

Q96NH3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-1315195_205479.0575.0Compositional biasNote=Asp/Glu-rich
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-1416195_205502.0598.0Compositional biasNote=Asp/Glu-rich
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-131525_183479.0575.0DomainTyrosine-protein phosphatase
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-141625_183502.0598.0DomainTyrosine-protein phosphatase
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-1315343_345479.0575.0Nucleotide bindingGTP
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-1315458_460479.0575.0Nucleotide bindingGTP
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-1416343_345502.0598.0Nucleotide bindingGTP
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-1416458_460502.0598.0Nucleotide bindingGTP
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-13151_212479.0575.0RegionNote=TPase
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-14161_212502.0598.0RegionNote=TPase
TgeneTBC1D32chr6:89388072chr6:121642940ENST000002751590331119_124251.6666666666666641299.0DomainNote=Rab-GAP TBC
TgeneTBC1D32chr6:89388072chr6:121642940ENST000003982120321119_124251.6666666666666641258.0DomainNote=Rab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-1315528_533479.0575.0Nucleotide bindingGTP
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-1416528_533502.0598.0Nucleotide bindingGTP
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-1315229_597479.0575.0RegionNote=GTase
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-1416229_597502.0598.0RegionNote=GTase


Top

Fusion Gene Sequence for RNGTT-TBC1D32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000538899_ENST00000275159_TCGA-VD-A8KJ-01A_RNGTT_chr6_89388072_-_TBC1D32_chr6_121642940_length(transcript)=5812nt_BP=1536nt
GCATTGTGGGTTCTCCTGGAGCTGTGGAGTTGATCCTGAATGAAAGTGGCGCGCCGCCCCTGACGTTACCCGGATCGGAGAGGTTGGAAT
TCAGATTACGGCTGCGATTCGGGTGTCTCGGACCCCGGTGTGCACCGGACCACGGGGAGGCGGCTCCAAAGGCGCGGTGAACGTTGGTGA
GGGAGGGCAGCTCTGCGCAGCCCCAAGACATGGCTCACAACAAGATCCCGCCGCGGTGGCTGAACTGTCCCCGGCGCGGCCAGCCGGTGG
CAGGTTAAAATGGGCTTGTTGGTGGACCTGACAAATACTTCAAGGTTCTATGACCGAAATGACATAGAAAAAGAAGGAATCAAATATATA
AAACTTCAGTGTAAAGGACATGGTGAGTGCCCTACCACTGAGAATACTGAGACCTTTATTCGTCTGTGTGAGCGGTTTAATGAAAGAAAT
CCACCTGAACTTATAGGTGTTCATTGTACTCATGGCTTCAATCGCACTGGTTTCCTCATATGTGCCTTTTTGGTGGAGAAAATGGATTGG
AGTATCGAAGCAGCAGTTGCTACTTTTGCCCAAGCCAGACCACCAGGAATCTACAAGGGTGATTATTTGAAGGAACTTTTTCGTCGGTAT
GGTGACATAGAGGAAGCACCACCCCCACCTCTATTGCCAGATTGGTGTTTTGAGGATGATGAAGACGAAGATGAGGATGAGGATGGAAAG
AAGGAATCAGAACCCGGGTCAAGTGCTTCTTTTGGCAAAAGGAGAAAAGAACGGTTAAAACTGGGCGCTATTTTCTTGGAAGGTGTTACT
GTTAAAGGTGTAACTCAAGTAACAACACAACCAAAGTTAGGAGAGGTACAGCAGAAGTGTCATCAATTCTGTGGCTGGGAAGGGTCTGGA
TTCCCTGGAGCACAGCCTGTTTCCATGGACAAGCAAAATATTAAACTTTTAGACCTGAAGCCATACAAAGTAAGCTGGAAAGCAGATGGT
ACTCGGTACATGATGTTGATTGATGGCACAAATGAAGTTTTTATGATTGATAGAGACAATTCAGTATTTCATGTTTCAAATCTGGAATTT
CCATTTCGTAAAGATCTTCGTATGCATTTATCAAATACTCTCTTGGATGGCGAGATGATTATTGACAGAGTAAATGGACAGGCTGTTCCT
AGATATTTGATATATGACATAATTAAATTCAATTCACAGCCCGTTGGAGATTGTGATTTTAATGTTCGTCTGCAGTGTATAGAACGAGAA
ATTATAAGTCCTCGACACGAAAAAATGAAGACTGGGCTCATTGACAAAACACAGGAACCATTTAGCGTCAGAAATAAGCCGTTTTTTGAC
ATCTGTACTTCAAGAAAGAAATACAAACCTGGTCGATGTGATGATATTTTGAAATGGAAGCCTCCCAGTCTGAATTCTGTGGATTTTCGT
CTAAAAATAACAAGAATGGGAGGAGAAGGGTTACTTCCTCAGAATGTTGGCCTCCTGTATGTTGGAGGTTATGAAAGACCCTTTGCACAA
ATCAAGCTATGAATTTGTGAAATACCTCAGGCAGCATATAGGCAACACTTTGGGTTCTATGATTGAAGAAGAAATGGAAAAATGCACATC
TGATCGGAATCAGGGTGAAGAATGCGGCTATGATACAGTTGTACAGCAGGTCACTAAAAGAACTCAAGAATCTAAAGAGTACAAAGAAAT
GATGCATTACCTGAAGAACATTATGATAGCTGTGGTCGAGTCTATGATTAACAAGTTTGAAGAAGATGAGACACGAAATCAAGAAAGGCA
GAAAAAAATCCAAAAGGAGAAAAGCCATAGTTACCGCACAGACAATTGCTCTGATAGTGATTCATCATTGAATCAGAGTTACAAATTTTG
TCAAGGAAAATTACAATTGATTTTAGACCAGTTGGATCCTGGGCAACCTAAAGAGGTGAGATATGAAGCCTTGCAAACATTATGTTCAGC
TCCTCCATCTGATGTCCTCAACTGTGAAAATTGGACTACTCTCTGCGAAAAACTGACCGTGTCTCTTTCAGATCCTGATCCTGTGTTTAG
TGACCGGATTTTAAAATTCTGTGCACAGACATTTTTGCTTTCTCCATTACATATGACCAAGGAAATTTATACAAGCTTAGCTAAGTATTT
GGAGTCATACTTTCTTTCTAGGGAAAATCATATTCCTACTCTTTCAGCTGGTGTAGATATAACTAATCCTAATATGACTCGCTTACTTAA
AAAGGTTCGTCTTCTAAATGAATATCAGAAAGAAGCTCCATCTTTCTGGATTCGTCATCCAGAGAAGTATATGGAAGAAATTGTGGAGAG
TACTTTGTCCTTGTTAACAGTTAAACATAATCAAAGCCATGTTGTCTCACAAAAGATTTTGGATCCGATCTACTTTTTTGCATTAGTTGA
TACCAAGGCTGTGTGGTTCAAAAAGTGGATGCATGCACATTATAGCAGAACTACAGTATTAAGACTTCTTGAAACGAAATATAAGTCTCT
GGTAACTACAGCCATTCAACAGTGTGTTCAGTACTTTGAAATGTGTAAGACTAGGAAAGCTGATGAAACTTTGGGACATTCAAAGCATTG
CAGAAACAAGCAGAAAACTTTCTACTACTTAGGACAAGAATTACAATATATTTATTTCATTCACTCACTGTGCCTTTTAGGAAGATTATT
GATCTATAAACAAGGCAGAAAACTATTTCCTATTAAGCTGAAGAATAAAAAAGGTTTGGTATCCCTCATAGATCTGCTTGTTCTTTTTAC
CCAACTTATCTATTACTCACCAAGTTGTCCAAAGATGACATCAGCTGCCCATTCAGAGAATTACTCTCCTGCAAGTATGGTGACTGAAGT
TCTGTGGATACTCAGTGATCAAAAAGAATGTGCAGTGGAATGCTTATATAACAACATTGTAATAGAGACACTTCTTCAGCCTATTCACAA
TTTAATGAAAGGAAATGAGGCATCTCCAAATTGCTCTGAGACAGCTTTAATTCATATAGCTGGTATTTTGGCAAGAATTGCATCTGTAGA
AGAAGGGCTTATTTTACTCCTTTATGGAGCAAATATGAACTCTTCTGAAGAAAGTCCTACAGGTGCTCATATAATTGCCCAGTTTTCGAA
AAAACTTCTCGATGAAGATATTTCTATATTTTCTGGATCAGAAATGTTGCCTGTGGTTAAAGGAGCTTTTATTTCTGTGTGTCGTCACAT
ATATAGTACATGTGAAGGTTTGCAGGTGTTAATCACTTATAATTTGCATGAATCTATAGCAAAGGCATGGAAAAAGACAAGTTTGCTATC
AGAAAGAATTCCTACTCCAGTAGAGGGTTCTGATTCTGTTTCTTCAGTAAGCCAGGAATCCCAAAACATTATGGCTTGGGAAGATAATTT
GTTAGATGATTTACTACATTTTGCTGCCACCCCCAAAGGATTACTACTTCTTCAAAGAACAGGTGCTATCAATGAATGTGTGACATTTAT
ATTCAATCGATATGCAAAAAAATTACAGGTCAGCAGGCATAAAAAATTTGGCTATGGAGTTTTGGTTACACGAGTGGCATCAACAGCAGC
AGGTGGCATTGCACTAAAAAAGTCAGGGTTTATTAATGAACTTATAACTGAATTATGGTCCAATCTGGAATATGGAAGAGATGATGTTAG
GGTAACCCATCCCAGAACTACTCCAGTGGATCCTATTGACCGAAGCTGTCAAAAGTCTTTTTTAGCACTGGTGAACTTGTTATCCTATCC
TGCTATTTATGAGCTTGTAAGGAATCAAGATCTTCCTAATAAAACAGAATATTCTCTTCGTGAAGTCCCAACATGTGTTATTGATATTAT
TGATAGACTTATAATTTTGAATTCTGAAGCTAAGATTCGTTCTTTATTCAACTATGAACAATCACATATCTTTGGTCTAAGGTTATTAAG
TGTGATATGCTGTGATCTGGACACTCTTCTCCTGTTAGAGGCTCAGTATCAGGTATCTGAAATGTTACTAAATGCTCAAGAAGAAAATAT
CTTGGAGATTTCTGAGAGCCACAGGGACTTTATAATTGATGGCTTATCAGTGGAGAGAAATCATGTTCTTGTTAGAATAAATCTTGTTGG
TGGGCCATTGGAACGGATTTTGCCTCCGAGGTTACTCGAAAAGAGTGATAATCCATATCCTTGGCCAATGTTTTCATCATATCCATTGCC
AAACTGCTATCTGTCAGACATTACAAGAAATGCTGGTATAAAACAAGACAATGATCTTGACAAGCTTTTATTATGCCTCAAAATATCTGA
TAAACAAACTGAATGGATAGAAAACTGCCAAAGACAATTTTGCAAAATGATGAAAGCCAAACCTGATATAATCAGTGGAGAGGCCTTAAT
AGAATTACTTGAAAAATTTGTGCTTCATCTCACTGAAAGCCCATCTGAATGCTACTTCCCTTCAGTGGAGTATACAGCTACTGATGCAAA
TGTGAAGAATGAAAGTCTTTCATCTGTGCAGCAGCTTGGCATTAAAATGACTGTCAGGTATGGCAAATTCCTCAGTCTCTTAAAAGATGG
TGCAGAAAATGATCTTACCTGGGTTTTAAAGCATTGTGAGAGATTCCTGAAACAGCAGCAAACTTCCATAAAATCTTCTCTTCTCTGCCT
GCAAGGGAATTATGCTGGCCATGACTGGTTTGTATCTTCTCTGTTCATGATAATGTTGGGAGACAAAGAAAAAACATTCCAATTTCTTCA
TCAATTCTCCAGGCTTCTGACTTCTGCTTTTCTTTGGTTGCCAAGGCTACATATTTCTAGTTACCTTCCTAATGACACTGTAGAATCTGG
CATCCATCCAGTATATTTTTGCAGCACCCATTATATTGAAATGCTACTGAAGGCTGAGTTGCCTCTTGTGTTTTCAGCTTTTCACATGTC
TGGTTTTGCACCATCACAGATTTGCCTGCAATGGATAACCCAGTGTTTTTGGAATTACTTAGATTGGATAGAAATCTGCCATTATATTGC
TACTTGTGTTTTCCTTGGTCCTGATTATCAAGTGTATATCTGTATAGCTGTATTCAAACATTTACAGCAAGACATTCTACAGCACACTCA
GACTCAAGATCTGCAAGTTTTCCTAAAAGAAGAAGCACTGCATGGGTTTCGAGTGAGTGATTATTTTGAATACATGGAAATTTTGGAACA
AAACTACCGAACAGTGCTGCTGAGAGACATGCGGAACATTAGACTGCAGAGCACATAGATCATGAGACACACGGTTTAAATTTAGGTTTT
ATTTATTTTTAAACACAGCAGGGGGGCTTGATGTTTTTCTGTGTCTGTAACAACATTTACTTTGTGAATATACATATTGTAAATACTGAG
AAGTATAACGATATATTTAAGTAGGTATGAGCTCAATTTGTGAATTCATTTTTGTAAATTTGTTGTTTTGTAAGGTTATTATAGAATCAG
ATCTAGCTTACTTTTAGTTCTTATTCATGTTTAAGAGTTAGTCCTGGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAG
TCTGAGGTGGGCGGATCACGAGGTCAAGAGATCGAGACCATCCTGGCCAAAATGGTGAAACCTCGTCTCTGCTAACAATACTGAAATTAG
CTGGGTGCAGTGATGCGCCTGTAGTCCCTGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAG

>In-frame_ENST00000538899_ENST00000275159_TCGA-VD-A8KJ-01A_RNGTT_chr6_89388072_-_TBC1D32_chr6_121642940_length(amino acids)=1264AA_start in transcript=1483_stop in transcript=5277
MLASCMLEVMKDPLHKSSYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYDTVVQQVTKRTQESKEYKEMMHYLKNIMIAVVES
MINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKFCQGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTL
CEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPS
FWIRHPEKYMEEIVESTLSLLTVKHNQSHVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEM
CKTRKADETLGHSKHCRNKQKTFYYLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTS
AAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNS
SEESPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSDSVS
SVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAGGIALKKSGFINEL
ITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLLSYPAIYELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRS
LFNYEQSHIFGLRLLSVICCDLDTLLLLEAQYQVSEMLLNAQEENILEISESHRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEK
SDNPYPWPMFSSYPLPNCYLSDITRNAGIKQDNDLDKLLLCLKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESP
SECYFPSVEYTATDANVKNESLSSVQQLGIKMTVRYGKFLSLLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSL
FMIMLGDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPNDTVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWITQ
CFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDILQHTQTQDLQVFLKEEALHGFRVSDYFEYMEILEQNYRTVLLRDMRNIR

--------------------------------------------------------------
>In-frame_ENST00000538899_ENST00000398212_TCGA-VD-A8KJ-01A_RNGTT_chr6_89388072_-_TBC1D32_chr6_121642940_length(transcript)=5155nt_BP=1536nt
GCATTGTGGGTTCTCCTGGAGCTGTGGAGTTGATCCTGAATGAAAGTGGCGCGCCGCCCCTGACGTTACCCGGATCGGAGAGGTTGGAAT
TCAGATTACGGCTGCGATTCGGGTGTCTCGGACCCCGGTGTGCACCGGACCACGGGGAGGCGGCTCCAAAGGCGCGGTGAACGTTGGTGA
GGGAGGGCAGCTCTGCGCAGCCCCAAGACATGGCTCACAACAAGATCCCGCCGCGGTGGCTGAACTGTCCCCGGCGCGGCCAGCCGGTGG
CAGGTTAAAATGGGCTTGTTGGTGGACCTGACAAATACTTCAAGGTTCTATGACCGAAATGACATAGAAAAAGAAGGAATCAAATATATA
AAACTTCAGTGTAAAGGACATGGTGAGTGCCCTACCACTGAGAATACTGAGACCTTTATTCGTCTGTGTGAGCGGTTTAATGAAAGAAAT
CCACCTGAACTTATAGGTGTTCATTGTACTCATGGCTTCAATCGCACTGGTTTCCTCATATGTGCCTTTTTGGTGGAGAAAATGGATTGG
AGTATCGAAGCAGCAGTTGCTACTTTTGCCCAAGCCAGACCACCAGGAATCTACAAGGGTGATTATTTGAAGGAACTTTTTCGTCGGTAT
GGTGACATAGAGGAAGCACCACCCCCACCTCTATTGCCAGATTGGTGTTTTGAGGATGATGAAGACGAAGATGAGGATGAGGATGGAAAG
AAGGAATCAGAACCCGGGTCAAGTGCTTCTTTTGGCAAAAGGAGAAAAGAACGGTTAAAACTGGGCGCTATTTTCTTGGAAGGTGTTACT
GTTAAAGGTGTAACTCAAGTAACAACACAACCAAAGTTAGGAGAGGTACAGCAGAAGTGTCATCAATTCTGTGGCTGGGAAGGGTCTGGA
TTCCCTGGAGCACAGCCTGTTTCCATGGACAAGCAAAATATTAAACTTTTAGACCTGAAGCCATACAAAGTAAGCTGGAAAGCAGATGGT
ACTCGGTACATGATGTTGATTGATGGCACAAATGAAGTTTTTATGATTGATAGAGACAATTCAGTATTTCATGTTTCAAATCTGGAATTT
CCATTTCGTAAAGATCTTCGTATGCATTTATCAAATACTCTCTTGGATGGCGAGATGATTATTGACAGAGTAAATGGACAGGCTGTTCCT
AGATATTTGATATATGACATAATTAAATTCAATTCACAGCCCGTTGGAGATTGTGATTTTAATGTTCGTCTGCAGTGTATAGAACGAGAA
ATTATAAGTCCTCGACACGAAAAAATGAAGACTGGGCTCATTGACAAAACACAGGAACCATTTAGCGTCAGAAATAAGCCGTTTTTTGAC
ATCTGTACTTCAAGAAAGAAATACAAACCTGGTCGATGTGATGATATTTTGAAATGGAAGCCTCCCAGTCTGAATTCTGTGGATTTTCGT
CTAAAAATAACAAGAATGGGAGGAGAAGGGTTACTTCCTCAGAATGTTGGCCTCCTGTATGTTGGAGGTTATGAAAGACCCTTTGCACAA
ATCAAGCTATGAATTTGTGAAATACCTCAGGCAGCATATAGGCAACACTTTGGGTTCTATGATTGAAGAAGAAATGGAAAAATGCACATC
TGATCGGAATCAGGGTGAAGAATGCGGCTATGATACAGTTGTACAGCAGGTCACTAAAAGAACTCAAGAATCTAAAGAGTACAAAGAAAT
GATGCATTACCTGAAGAACATTATGATAGCTGTGGTCGAGTCTATGATTAACAAGTTTGAAGAAGATGAGACACGAAATCAAGAAAGGCA
GAAAAAAATCCAAAAGGAGAAAAGCCATAGTTACCGCACAGACAATTGCTCTGATAGTGATTCATCATTGAATCAGAGTTACAAATTTTG
TCAAGGAAAATTACAATTGATTTTAGACCAGTTGGATCCTGGGCAACCTAAAGAGGTGAGATATGAAGCCTTGCAAACATTATGTTCAGC
TCCTCCATCTGATGTCCTCAACTGTGAAAATTGGACTACTCTCTGCGAAAAACTGACCGTGTCTCTTTCAGATCCTGATCCTGTGTTTAG
TGACCGGATTTTAAAATTCTGTGCACAGACATTTTTGCTTTCTCCATTACATATGACCAAGGAAATTTATACAAGCTTAGCTAAGTATTT
GGAGTCATACTTTCTTTCTAGGGAAAATCATATTCCTACTCTTTCAGCTGGTGTAGATATAACTAATCCTAATATGACTCGCTTACTTAA
AAAGGTTCGTCTTCTAAATGAATATCAGAAAGAAGCTCCATCTTTCTGGATTCGTCATCCAGAGAAGTATATGGAAGAAATTGTGGAGAG
TACTTTGTCCTTGTTAACAGTTAAACATAATCAAAGCCATGTTGTCTCACAAAAGATTTTGGATCCGATCTACTTTTTTGCATTAGTTGA
TACCAAGGCTGTGTGGTTCAAAAAGTGGATGCATGCACATTATAGCAGAACTACAGTATTAAGACTTCTTGAAACGAAATATAAGTCTCT
GGTAACTACAGCCATTCAACAGTGTGTTCAGTACTTTGAAATGTGTAAGACTAGGAAAGCTGATGAAACTTTGGGACATTCAAAGCATTG
CAGAAACAAGCAGAAAACTTTCTACTACTTAGGACAAGAATTACAATATATTTATTTCATTCACTCACTGTGCCTTTTAGGAAGATTATT
GATCTATAAACAAGGCAGAAAACTATTTCCTATTAAGCTGAAGAATAAAAAAGGTTTGGTATCCCTCATAGATCTGCTTGTTCTTTTTAC
CCAACTTATCTATTACTCACCAAGTTGTCCAAAGATGACATCAGCTGCCCATTCAGAGAATTACTCTCCTGCAAGTATGGTGACTGAAGT
TCTGTGGATACTCAGTGATCAAAAAGAATGTGCAGTGGAATGCTTATATAACAACATTGTAATAGAGACACTTCTTCAGCCTATTCACAA
TTTAATGAAAGGAAATGAGGCATCTCCAAATTGCTCTGAGACAGCTTTAATTCATATAGCTGGTATTTTGGCAAGAATTGCATCTGTAGA
AGAAGGGCTTATTTTACTCCTTTATGGAGCAAATATGAACTCTTCTGAAGAAAGTCCTACAGGTGCTCATATAATTGCCCAGTTTTCGAA
AAAACTTCTCGATGAAGATATTTCTATATTTTCTGGATCAGAAATGTTGCCTGTGGTTAAAGGAGCTTTTATTTCTGTGTGTCGTCACAT
ATATAGTACATGTGAAGGTTTGCAGGTGTTAATCACTTATAATTTGCATGAATCTATAGCAAAGGCATGGAAAAAGACAAGTTTGCTATC
AGAAAGAATTCCTACTCCAGTAGAGGGTTCTGATTCTGTTTCTTCAGTAAGCCAGGAATCCCAAAACATTATGGCTTGGGAAGATAATTT
GTTAGATGATTTACTACATTTTGCTGCCACCCCCAAAGGATTACTACTTCTTCAAAGAACAGGTGCTATCAATGAATGTGTGACATTTAT
ATTCAATCGATATGCAAAAAAATTACAGGTCAGCAGGCATAAAAAATTTGGCTATGGAGTTTTGGTTACACGAGTGGCATCAACAGCAGC
AGGTGGCATTGCACTAAAAAAGTCAGGGTTTATTAATGAACTTATAACTGAATTATGGTCCAATCTGGAATATGGAAGAGATGATGTTAG
GGTAACCCATCCCAGAACTACTCCAGTGGATCCTATTGACCGAAGCTGTCAAAAGTCTTTTTTAGCACTGGTGAACTTGTTATCCTATCC
TGCTATTTATGAGCTTGTAAGGAATCAAGATCTTCCTAATAAAACAGAATATTCTCTTCGTGAAGTCCCAACATGTGTTATTGATATTAT
TGATAGACTTATAATTTTGAATTCTGAAGCTAAGATTCGTTCTTTATTCAACTATGAACAATCACATATCTTTGGTCTAAGGGACTTTAT
AATTGATGGCTTATCAGTGGAGAGAAATCATGTTCTTGTTAGAATAAATCTTGTTGGTGGGCCATTGGAACGGATTTTGCCTCCGAGGTT
ACTCGAAAAGAGTGATAATCCATATCCTTGGCCAATGTTTTCATCATATCCATTGCCAAACTGCTATCTGTCAGACATTACAAGAAATGC
TGGTATAAAACAAGACAATGATCTTGACAAGCTTTTATTATGCCTCAAAATATCTGATAAACAAACTGAATGGATAGAAAACTGCCAAAG
ACAATTTTGCAAAATGATGAAAGCCAAACCTGATATAATCAGTGGAGAGGCCTTAATAGAATTACTTGAAAAATTTGTGCTTCATCTCAC
TGAAAGCCCATCTGAATGCTACTTCCCTTCAGTGGAGTATACAGCTACTGATGCAAATGTGAAGAATGAAAGTCTTTCATCTGTGCAGCA
GCTTGGCATTAAAATGACTGTCAGGTATGGCAAATTCCTCAGTCTCTTAAAAGATGGTGCAGAAAATGATCTTACCTGGGTTTTAAAGCA
TTGTGAGAGATTCCTGAAACAGCAGCAAACTTCCATAAAATCTTCTCTTCTCTGCCTGCAAGGGAATTATGCTGGCCATGACTGGTTTGT
ATCTTCTCTGTTCATGATAATGTTGGGAGACAAAGAAAAAACATTCCAATTTCTTCATCAATTCTCCAGGCTTCTGACTTCTGCTTTTCT
TTGGTTGCCAAGGCTACATATTTCTAGTTACCTTCCTAATGACACTGTAGAATCTGGCATCCATCCAGTATATTTTTGCAGCACCCATTA
TATTGAAATGCTACTGAAGGCTGAGTTGCCTCTTGTGTTTTCAGCTTTTCACATGTCTGGTTTTGCACCATCACAGATTTGCCTGCAATG
GATAACCCAGTGTTTTTGGAATTACTTAGATTGGATAGAAATCTGCCATTATATTGCTACTTGTGTTTTCCTTGGTCCTGATTATCAAGT
GTATATCTGTATAGCTGTATTCAAACATTTACAGCAAGACATTCTACAGCACACTCAGACTCAAGATCTGCAAGTTTTCCTAAAAGAAGA
AGCACTGCATGGGTTTCGAGTGAGTGATTATTTTGAATACATGGAAATTTTGGAACAAAACTACCGAACAGTGCTGCTGAGAGACATGCG

>In-frame_ENST00000538899_ENST00000398212_TCGA-VD-A8KJ-01A_RNGTT_chr6_89388072_-_TBC1D32_chr6_121642940_length(amino acids)=1224AA_start in transcript=1483_stop in transcript=5154
MLASCMLEVMKDPLHKSSYEFVKYLRQHIGNTLGSMIEEEMEKCTSDRNQGEECGYDTVVQQVTKRTQESKEYKEMMHYLKNIMIAVVES
MINKFEEDETRNQERQKKIQKEKSHSYRTDNCSDSDSSLNQSYKFCQGKLQLILDQLDPGQPKEVRYEALQTLCSAPPSDVLNCENWTTL
CEKLTVSLSDPDPVFSDRILKFCAQTFLLSPLHMTKEIYTSLAKYLESYFLSRENHIPTLSAGVDITNPNMTRLLKKVRLLNEYQKEAPS
FWIRHPEKYMEEIVESTLSLLTVKHNQSHVVSQKILDPIYFFALVDTKAVWFKKWMHAHYSRTTVLRLLETKYKSLVTTAIQQCVQYFEM
CKTRKADETLGHSKHCRNKQKTFYYLGQELQYIYFIHSLCLLGRLLIYKQGRKLFPIKLKNKKGLVSLIDLLVLFTQLIYYSPSCPKMTS
AAHSENYSPASMVTEVLWILSDQKECAVECLYNNIVIETLLQPIHNLMKGNEASPNCSETALIHIAGILARIASVEEGLILLLYGANMNS
SEESPTGAHIIAQFSKKLLDEDISIFSGSEMLPVVKGAFISVCRHIYSTCEGLQVLITYNLHESIAKAWKKTSLLSERIPTPVEGSDSVS
SVSQESQNIMAWEDNLLDDLLHFAATPKGLLLLQRTGAINECVTFIFNRYAKKLQVSRHKKFGYGVLVTRVASTAAGGIALKKSGFINEL
ITELWSNLEYGRDDVRVTHPRTTPVDPIDRSCQKSFLALVNLLSYPAIYELVRNQDLPNKTEYSLREVPTCVIDIIDRLIILNSEAKIRS
LFNYEQSHIFGLRDFIIDGLSVERNHVLVRINLVGGPLERILPPRLLEKSDNPYPWPMFSSYPLPNCYLSDITRNAGIKQDNDLDKLLLC
LKISDKQTEWIENCQRQFCKMMKAKPDIISGEALIELLEKFVLHLTESPSECYFPSVEYTATDANVKNESLSSVQQLGIKMTVRYGKFLS
LLKDGAENDLTWVLKHCERFLKQQQTSIKSSLLCLQGNYAGHDWFVSSLFMIMLGDKEKTFQFLHQFSRLLTSAFLWLPRLHISSYLPND
TVESGIHPVYFCSTHYIEMLLKAELPLVFSAFHMSGFAPSQICLQWITQCFWNYLDWIEICHYIATCVFLGPDYQVYICIAVFKHLQQDI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RNGTT-TBC1D32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRNGTTchr6:89388072chr6:121642940ENST00000265607-1315330_386479.0575.0POLR2A
HgeneRNGTTchr6:89388072chr6:121642940ENST00000369485-1416330_386502.0598.0POLR2A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RNGTT-TBC1D32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RNGTT-TBC1D32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTBC1D32C0796102Orofaciodigital syndrome 91GENOMICS_ENGLAND
TgeneTBC1D32C1709353Osteofibrous Dysplasia1GENOMICS_ENGLAND
TgeneTBC1D32C4085248OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO1GENOMICS_ENGLAND