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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ROCK2-DTNB (FusionGDB2 ID:74857) |
Fusion Gene Summary for ROCK2-DTNB |
Fusion gene summary |
Fusion gene information | Fusion gene name: ROCK2-DTNB | Fusion gene ID: 74857 | Hgene | Tgene | Gene symbol | ROCK2 | DTNB | Gene ID | 9475 | 1838 |
Gene name | Rho associated coiled-coil containing protein kinase 2 | dystrobrevin beta | |
Synonyms | ROCK-II | - | |
Cytomap | 2p25.1 | 2p23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II | dystrobrevin betaDTN-Bbeta-dystrobrevin | |
Modification date | 20200329 | 20200327 | |
UniProtAcc | . | Q96EV8 | |
Ensembl transtripts involved in fusion gene | ENST00000315872, ENST00000462366, ENST00000401753, | ENST00000496972, ENST00000405222, ENST00000407661, ENST00000406818, ENST00000407038, ENST00000404103, ENST00000407186, ENST00000288642, ENST00000545439, ENST00000472690, | |
Fusion gene scores | * DoF score | 16 X 11 X 9=1584 | 14 X 13 X 9=1638 |
# samples | 17 | 15 | |
** MAII score | log2(17/1584*10)=-3.21996568394191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1638*10)=-3.44890095114513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ROCK2 [Title/Abstract] AND DTNB [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ROCK2(11484122)-DTNB(25656864), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ROCK2 | GO:0006468 | protein phosphorylation | 18559669 |
Fusion gene breakpoints across ROCK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across DTNB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-67-3770-01A | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
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Fusion Gene ORF analysis for ROCK2-DTNB |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000315872 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
In-frame | ENST00000315872 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
5CDS-intron | ENST00000315872 | ENST00000472690 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000462366 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-intron | ENST00000462366 | ENST00000472690 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-3CDS | ENST00000401753 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
intron-intron | ENST00000401753 | ENST00000472690 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000496972 | DTNB | chr2 | 25656864 | - | 1527 | 590 | 449 | 1141 | 230 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000405222 | DTNB | chr2 | 25656864 | - | 1446 | 590 | 449 | 1105 | 218 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000407661 | DTNB | chr2 | 25656864 | - | 1503 | 590 | 449 | 1162 | 237 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000406818 | DTNB | chr2 | 25656864 | - | 1557 | 590 | 449 | 1216 | 255 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000407038 | DTNB | chr2 | 25656864 | - | 1467 | 590 | 449 | 1126 | 225 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000404103 | DTNB | chr2 | 25656864 | - | 1467 | 590 | 449 | 1126 | 225 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000407186 | DTNB | chr2 | 25656864 | - | 1521 | 590 | 449 | 1195 | 248 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000288642 | DTNB | chr2 | 25656864 | - | 1448 | 590 | 449 | 1126 | 225 |
ENST00000315872 | ROCK2 | chr2 | 11484122 | - | ENST00000545439 | DTNB | chr2 | 25656864 | - | 1263 | 590 | 449 | 1195 | 248 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000315872 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.020974854 | 0.9790252 |
ENST00000315872 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.007351719 | 0.9926483 |
ENST00000315872 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.012134508 | 0.9878655 |
ENST00000315872 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.005707629 | 0.9942924 |
ENST00000315872 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.00487301 | 0.99512696 |
ENST00000315872 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.00487301 | 0.99512696 |
ENST00000315872 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.008680699 | 0.99131924 |
ENST00000315872 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.004470892 | 0.9955291 |
ENST00000315872 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - | 0.008695015 | 0.991305 |
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Fusion Genomic Features for ROCK2-DTNB |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ROCK2-DTNB |
Go to FGviewer for the breakpoints of chr2:11484122-chr2:25656864 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | DTNB |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269|PubMed:15345706, ECO:0000269|PubMed:16837549, ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:17989303, ECO:0000269|PubMed:19094965, ECO:0000269|PubMed:20180862, ECO:0000269|PubMed:20921223}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000404103 | 11 | 20 | 428_529 | 419.0 | 607.3333333333334 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000405222 | 10 | 18 | 428_529 | 389.0 | 570.3333333333334 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000406818 | 11 | 21 | 428_529 | 419.0 | 637.3333333333334 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407038 | 10 | 19 | 428_529 | 389.0 | 577.3333333333334 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407661 | 11 | 20 | 428_529 | 419.0 | 619.3333333333334 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000496972 | 10 | 18 | 428_529 | 362.0 | 581.3333333333334 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000405222 | 10 | 18 | 399_448 | 389.0 | 570.3333333333334 | Region | Note=Syntrophin-binding region | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407038 | 10 | 19 | 399_448 | 389.0 | 577.3333333333334 | Region | Note=Syntrophin-binding region | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000496972 | 10 | 18 | 399_448 | 362.0 | 581.3333333333334 | Region | Note=Syntrophin-binding region |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 1053_1131 | 47.0 | 1389.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 429_1024 | 47.0 | 1389.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 1150_1349 | 47.0 | 1389.0 | Domain | PH |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 357_425 | 47.0 | 1389.0 | Domain | AGC-kinase C-terminal |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 497_573 | 47.0 | 1389.0 | Domain | REM-1 |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 92_354 | 47.0 | 1389.0 | Domain | Protein kinase |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 98_106 | 47.0 | 1389.0 | Nucleotide binding | ATP |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 979_1047 | 47.0 | 1389.0 | Region | RHOA binding |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 1260_1315 | 47.0 | 1389.0 | Zinc finger | Phorbol-ester/DAG-type |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000404103 | 11 | 20 | 399_448 | 419.0 | 607.3333333333334 | Region | Note=Syntrophin-binding region | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000406818 | 11 | 21 | 399_448 | 419.0 | 637.3333333333334 | Region | Note=Syntrophin-binding region | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407661 | 11 | 20 | 399_448 | 419.0 | 619.3333333333334 | Region | Note=Syntrophin-binding region | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000404103 | 11 | 20 | 237_284 | 419.0 | 607.3333333333334 | Zinc finger | ZZ-type | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000405222 | 10 | 18 | 237_284 | 389.0 | 570.3333333333334 | Zinc finger | ZZ-type | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000406818 | 11 | 21 | 237_284 | 419.0 | 637.3333333333334 | Zinc finger | ZZ-type | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407038 | 10 | 19 | 237_284 | 389.0 | 577.3333333333334 | Zinc finger | ZZ-type | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407661 | 11 | 20 | 237_284 | 419.0 | 619.3333333333334 | Zinc finger | ZZ-type | |
Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000496972 | 10 | 18 | 237_284 | 362.0 | 581.3333333333334 | Zinc finger | ZZ-type |
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Fusion Gene Sequence for ROCK2-DTNB |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000315872_ENST00000496972_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1527nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGG TGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCA GGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCAC ACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGT GGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAG >In-frame_ENST00000315872_ENST00000496972_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=230AA_start in transcript=449_stop in transcript=1141 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000405222_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1446nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGA TGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATG GCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTC CACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGC ATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAG >In-frame_ENST00000315872_ENST00000405222_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=218AA_start in transcript=449_stop in transcript=1105 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000407661_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1503nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAA ACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGGTTAGCAGAGGA GCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTC CTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTG GGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGC >In-frame_ENST00000315872_ENST00000407661_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=237AA_start in transcript=449_stop in transcript=1162 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000406818_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1557nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAA ACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ENST00000315872_ENST00000406818_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=255AA_start in transcript=449_stop in transcript=1216 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000407038_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1467nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ENST00000315872_ENST00000407038_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=225AA_start in transcript=449_stop in transcript=1126 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000404103_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1467nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ENST00000315872_ENST00000404103_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=225AA_start in transcript=449_stop in transcript=1126 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000407186_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1521nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGG TGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGA TGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATG GCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTC CACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGC >In-frame_ENST00000315872_ENST00000407186_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=248AA_start in transcript=449_stop in transcript=1195 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000288642_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1448nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAAGCTGAGGCAC GAGAATCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ENST00000315872_ENST00000288642_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=225AA_start in transcript=449_stop in transcript=1126 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEAEARESAQATGSPHTSPTHGGGRPMPMPVRSTS -------------------------------------------------------------- >In-frame_ENST00000315872_ENST00000545439_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(transcript)=1263nt_BP=590nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGG TGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGA TGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATG >In-frame_ENST00000315872_ENST00000545439_TCGA-67-3770-01A_ROCK2_chr2_11484122_-_DTNB_chr2_25656864_length(amino acids)=248AA_start in transcript=449_stop in transcript=1195 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ROCK2-DTNB |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 373_420 | 47.0 | 1389.0 | NPM1 |
Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 363_784 | 47.0 | 1389.0 | PPP1R12A |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ROCK2-DTNB |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ROCK2-DTNB |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ROCK2 | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | ROCK2 | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ROCK2 | C0018802 | Congestive heart failure | 1 | CTD_human |
Hgene | ROCK2 | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Hgene | ROCK2 | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Hgene | ROCK2 | C0600519 | Ventricular Remodeling | 1 | CTD_human |
Hgene | ROCK2 | C0600520 | Left Ventricle Remodeling | 1 | CTD_human |
Hgene | ROCK2 | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
Hgene | ROCK2 | C1959583 | Myocardial Failure | 1 | CTD_human |
Hgene | ROCK2 | C1961112 | Heart Decompensation | 1 | CTD_human |