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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ROCK2-PPP2CA (FusionGDB2 ID:74869)

Fusion Gene Summary for ROCK2-PPP2CA

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK2-PPP2CA
	Fusion gene ID: 74869
		Hgene	Tgene
	Gene symbol	ROCK2	PPP2CA
	Gene ID	9475	5515
	Gene name	Rho associated coiled-coil containing protein kinase 2	protein phosphatase 2 catalytic subunit alpha
	Synonyms	ROCK-II	NEDLBA\|PP2Ac\|PP2CA\|PP2Calpha\|RP-C
	Cytomap	2p25.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformPP2A-alphaprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprotein phosphatase 2, catalytic subunit, alpha isozymereplication protein Cserine/threonine protein
	Modification date	20200329	20200315
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000315872, ENST00000462366, ENST00000401753,	ENST00000481195, ENST00000231504,
Fusion gene scores	* DoF score	16 X 11 X 9=1584	8 X 8 X 5=320
	# samples	17	11
	** MAII score	log2(17/1584*10)=-3.21996568394191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/320*10)=-1.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ROCK2 [Title/Abstract] AND PPP2CA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK2(11484122)-PPP2CA(133541822), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK2	GO:0006468	protein phosphorylation	18559669
Tgene	PPP2CA	GO:0035970	peptidyl-threonine dephosphorylation	30611118

Fusion gene breakpoints across ROCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP2CA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0HL-01A	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
ChimerDB4	BRCA	TCGA-BH-A0HL	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
ChimerDB4	BRCA	TCGA-BH-A0HL-01A	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-

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Fusion Gene ORF analysis for ROCK2-PPP2CA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000315872	ENST00000481195	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
5CDS-5UTR	ENST00000315872	ENST00000231504	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
intron-3CDS	ENST00000462366	ENST00000481195	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
intron-5UTR	ENST00000462366	ENST00000231504	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
intron-3CDS	ENST00000401753	ENST00000481195	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
intron-5UTR	ENST00000401753	ENST00000231504	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-
In-frame	ENST00000315872	ENST00000481195	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
5CDS-5UTR	ENST00000315872	ENST00000231504	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
intron-3CDS	ENST00000462366	ENST00000481195	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
intron-5UTR	ENST00000462366	ENST00000231504	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
intron-3CDS	ENST00000401753	ENST00000481195	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-
intron-5UTR	ENST00000401753	ENST00000231504	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000315872	ROCK2	chr2	11484122	-	ENST00000481195	PPP2CA	chr5	133541822	-	4856	590	449	1417	322
ENST00000315872	ROCK2	chr2	11484121	-	ENST00000481195	PPP2CA	chr5	133541822	-	4856	590	449	1417	322

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000315872	ENST00000481195	ROCK2	chr2	11484122	-	PPP2CA	chr5	133541822	-	0.000151764	0.99984825
ENST00000315872	ENST00000481195	ROCK2	chr2	11484121	-	PPP2CA	chr5	133541822	-	0.000151764	0.99984825

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Fusion Genomic Features for ROCK2-PPP2CA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROCK2-PPP2CA

Go to
FGviewer for the breakpoints of chr2:11484122-chr5:133541822
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

1053_1131

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

429_1024

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

1053_1131

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

429_1024

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

1150_1349

47.0

1389.0

Domain

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

357_425

47.0

1389.0

Domain

AGC-kinase C-terminal

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

497_573

47.0

1389.0

Domain

REM-1

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

92_354

47.0

1389.0

Domain

Protein kinase

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

1150_1349

47.0

1389.0

Domain

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

357_425

47.0

1389.0

Domain

AGC-kinase C-terminal

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

497_573

47.0

1389.0

Domain

REM-1

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

92_354

47.0

1389.0

Domain

Protein kinase

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

98_106

47.0

1389.0

Nucleotide binding

ATP

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

98_106

47.0

1389.0

Nucleotide binding

ATP

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

979_1047

47.0

1389.0

Region

RHOA binding

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

979_1047

47.0

1389.0

Region

RHOA binding

Hgene

ROCK2

chr2:11484121

chr5:133541822

ENST00000315872

1260_1315

47.0

1389.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

ROCK2

chr2:11484122

chr5:133541822

ENST00000315872

1260_1315

47.0

1389.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Gene Sequence for ROCK2-PPP2CA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000315872_ENST00000481195_TCGA-BH-A0HL-01A_ROCK2_chr2_11484122_-_PPP2CA_chr5_133541822_length(transcript)=4856nt_BP=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGCTAAAGAAATCCTGACAAAAGAATCCAACGTGCAAGAGG
TTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGGCAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATA
CAAATTACTTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTTGTAGCTCTTAAGGTTCGTTACC
GTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGCAGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATATG
GAAATGCAAATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGATGGGCAGATCTTCTGTCTACATG
GTGGTCTCTCGCCATCTATAGATACACTGGATCATATCAGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGACT
TGCTGTGGTCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTTGGGCAAGATATTTCTGAGACAT
TTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCTCACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTAA
CGATTTTCAGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGATACTCTAAAATACTCTTTCTTGC
AGTTTGACCCAGCACCTCGTAGAGGCGAGCCACATGTTACTCGTCGTACCCCAGACTACTTCCTGTAATGAAATTTTAAACTTGTACAGT
ATTGCCATGAACCATATATCGACCTAATGGAAATGGGAAGAGCAACAGTAACTCCAAAGTGTCAGAAAATAGTTAACATTCAAAAAACTT
GTTTTCACATGGACCAAAAGATGTGCCATATAAAAATACAAAGCCTCTTGTCATCAACAGCCGTGACCACTTTAGAATGAACCAGTTCAT
TGCATGCTGAAGCGACATTGTTGGTCAAGAAACCAGTTTCTGGCATAGCGCTATTTGTAGTTACTTTTGCTTTCTCTGAGAGACTGCAGA
TAATAAGATGTAAACATTAACACCTCGTGAATACAATTTAACTTCCATTTAGCTATAGCTTTACTCAGCATGACTGTAGATAAGGATAGC
AGCAAACAATCATTGGAGCTTAATGAACATTTTTAAAAATAATTACCAAGGCCTCCCTTCTACTTGTGAGTTTTGAAATTGTTCTTTTTA
TTTTCAGGGATACCGTTTAATTTAATTATATGATTTGTCTGCACTCAGTTTATTCCCTACTCAAATCTCAGCCCCATGTTGTTCTTTGTT
ATTGTCAGAACCTGGTGAGTTGTTTTGAACAGAACTGTTTTTTCCCCTTCCTGTAAGACGATGTGACTGCACAAGAGCACTGCAGTGTTT
TTCATAATAAACTTGTGAACTAAGAACTGAGAAGGTCAAATTTTAATTGTATCAATGGGCAAGACTGGTGCTGTTTATTAAAAAAGTTAA
ATCAATTGAGTAAATTTTAGAATTTGTAGACTTGTAGGTAAAATAAAAATCAAGGGCACTACATAACCTCTCTGGTAACTCCTTGACATT
CTTCAGATTAACTTCAGGATTTATTTGTATTTCACATATTACAATTTGTCACATTGTTGGTGTGCACTTTGTGGGTTCTTCCTGCATATT
AACTTGTTTGTAAGAAAGGAAATCTGTGCTGCTTCAGTAAGACTTAATTGTAAAACCATATAACTTGAGATTTAAGTCTTTGGGTTTTGT
TTTAATAAAACAGCATGTTTTCAGGTAGAGCTTAAACTAAATGATGTGTTTACTTAGTGCAGTTTCTGGTTATGAATATTATATTGCTAT
GTGTATATTATATGGACTCTTTAAAATGATTGACAGATTGGCAAATTCTTAAATCTTTGTACATTGTTGAGTCATATGTTCTTAGAGTTA
AATTTGTCTCAGATAAGAAAGTGTTAAAGCATTAGCCTGTGTCAAGTTCTTTGAGTGATACTAGTGAAACCAAATAGAAAACTATTGTTG
GATCATGATTTAGTCTTATGTACATTCACCCGAAGACAAAAATGGTACTTAAAGTGGCAGTGTTCAACATTTAATGAGTTTTTCCCCTTT
TATCCTTCGAATAGGATTAGATGTTTAAAAAAAAGTTCTTCTGTGGGAACTAATATTTGATATTTTAACCTACCAGAGTAAACAGGAACA
CTTAATCATACTTGTGAGTGTAGTAAATAAAAGTTTTCTTGCTTTGTGCTGTGTTGAATCTGGAACCAACAGGGAAGTTATAGCATATCC
CCTTTCTAAAATGCTTGAGGAACACATACATACCGAATGTCTTTTCTGATCTAATTGATAGTATTTTTAGTGGCTTGTGGAGTTAATTTT
CCAAAGCAAAAGGCCATTAGGGTTTCTACATTTCATTTCATTTCATTCTTTTCTTTCACAAGAAATACATTCTCTGTGTGTCTTTTTGTT
GCTCTGTCACTCTATGCCCTTTCTCTCCGACTGAACAAATAGCTTATCCATGTGCAGTGGTTTTAATACCCAAACAATCTAGACACCAAG
CAGCTATTTTTTCCGGTCCTGTGATATCAGAATTGACCAAGGAATACGTATATTGTAATTGACACGTGGTGGTATCTTCCAGGTACAAAT
TCTCTAAATTTTGTGGTTAGCAGAATGGGACTTGTGATAAGAATAGCTTGGTTTTAGCATAACTAGGGTTTAAAATAATTGTTTAATTAT
AGAGACTGACCGGGCTTTGGCCATCTAAACTGGAAAGTGTTAGTACCCTACCTTCTTTTGAAAATGGCTATGGTAAGGAAAATGTGTTAG
TAAATTATGTATTTTCTTGAAAAATACATAATTATGGTTGGATGGGAATCACTAAGTTGGGTGTTAACTGATGTCTCAATTAGTAACATT
AGGATTTTCATTAATAAACCTAAAAAGCTTTCCCTAAGAACAGGCCTGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACC
AGGGTGGGTGGATCCCTTGAGGTCAGGAGTTGAAGAGCAGCCTGGCCAACATGGCAAAACCCCATCTCTACAAAAAATATGAAAATCAGC
CGGGCTTGGTGGCATACCATAGTCCCAGCTACTTGGGAGGCTGAGGTGAGAGGATCGCCTGAGCCCAGGAGATGGAGGTTGCAGTGGGCT
GAGATTGTGCCACTGTACTCCAGTCTGGGTGACAGAGCCAGACCCTGTCTCAAAAATAAAGAGGATTCTGAGTTTGTATAGTGAGGGCTT
GCAGAAATTTTGAAACTTATTTTGTAAGTTTACAATGAATTTGTACATGATGTGCTCATGTCTTGGGTTGAGTATCCTAGACATGATTTT
TTCATTTGCTGCATATTAAACATTTGTTGGTTGTAGTCGGTATTTCTTAAATAGAAGTTTGTCAATATTAGATTAGTTTCAAGAAGGACT
TAGCTCAGGAAAAGGATAGTTATTTCTGTGGTTCTCAGCTTTGATGCCTACAGAGATTCTGATTTAAATTGCTGGAGGAGGGCCCAGGCA
TACATTTTTTAAGTTTCCCAAGTGATTCTAATTTACATCTAGGGTTAAAAACAGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACT
TGGGGAGGCCGGGGTGGGTGGATCACCTGATGTCAGGAGATCGAGACCAGCCTGGCCAGCGTGGTGAAACCCCATCTCTATTAAAAATAC
AAAACTGACCGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGAGGAGGT
TACAGTGAGCCCAGATCGTGCCATTGCACTCCAGCCTGGGCAAAAAGAGCAAAACTCCATCTCAAAAAACAAAAACACCTCACTGCTGTT
TCCTAAGTACATACTTAAGAAAATTGGGATACATGGTGGTGGTTCATGGATGTTGATAAGGAATTAAAATGTACCGTGCGACTCTCTGTT
TCAGTGGTGACTTTTACCTGTTTAGTATAAATATTCCTTTGCTTCCAACCATAAATGTGTTCTTAGAAATGGGCCTATAGTTTAGTAACC

>In-frame_ENST00000315872_ENST00000481195_TCGA-BH-A0HL-01A_ROCK2_chr2_11484122_-_PPP2CA_chr5_133541822_length(amino acids)=322AA_start in transcript=449_stop in transcript=1417
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPD
TNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLH
GGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVV

--------------------------------------------------------------
>In-frame_ENST00000315872_ENST00000481195_TCGA-BH-A0HL_ROCK2_chr2_11484121_-_PPP2CA_chr5_133541822_length(transcript)=4856nt_BP=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGCTAAAGAAATCCTGACAAAAGAATCCAACGTGCAAGAGG
TTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGGCAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATA
CAAATTACTTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTTGTAGCTCTTAAGGTTCGTTACC
GTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGCAGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATATG
GAAATGCAAATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGATGGGCAGATCTTCTGTCTACATG
GTGGTCTCTCGCCATCTATAGATACACTGGATCATATCAGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGACT
TGCTGTGGTCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTTGGGCAAGATATTTCTGAGACAT
TTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCTCACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTAA
CGATTTTCAGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGATACTCTAAAATACTCTTTCTTGC
AGTTTGACCCAGCACCTCGTAGAGGCGAGCCACATGTTACTCGTCGTACCCCAGACTACTTCCTGTAATGAAATTTTAAACTTGTACAGT
ATTGCCATGAACCATATATCGACCTAATGGAAATGGGAAGAGCAACAGTAACTCCAAAGTGTCAGAAAATAGTTAACATTCAAAAAACTT
GTTTTCACATGGACCAAAAGATGTGCCATATAAAAATACAAAGCCTCTTGTCATCAACAGCCGTGACCACTTTAGAATGAACCAGTTCAT
TGCATGCTGAAGCGACATTGTTGGTCAAGAAACCAGTTTCTGGCATAGCGCTATTTGTAGTTACTTTTGCTTTCTCTGAGAGACTGCAGA
TAATAAGATGTAAACATTAACACCTCGTGAATACAATTTAACTTCCATTTAGCTATAGCTTTACTCAGCATGACTGTAGATAAGGATAGC
AGCAAACAATCATTGGAGCTTAATGAACATTTTTAAAAATAATTACCAAGGCCTCCCTTCTACTTGTGAGTTTTGAAATTGTTCTTTTTA
TTTTCAGGGATACCGTTTAATTTAATTATATGATTTGTCTGCACTCAGTTTATTCCCTACTCAAATCTCAGCCCCATGTTGTTCTTTGTT
ATTGTCAGAACCTGGTGAGTTGTTTTGAACAGAACTGTTTTTTCCCCTTCCTGTAAGACGATGTGACTGCACAAGAGCACTGCAGTGTTT
TTCATAATAAACTTGTGAACTAAGAACTGAGAAGGTCAAATTTTAATTGTATCAATGGGCAAGACTGGTGCTGTTTATTAAAAAAGTTAA
ATCAATTGAGTAAATTTTAGAATTTGTAGACTTGTAGGTAAAATAAAAATCAAGGGCACTACATAACCTCTCTGGTAACTCCTTGACATT
CTTCAGATTAACTTCAGGATTTATTTGTATTTCACATATTACAATTTGTCACATTGTTGGTGTGCACTTTGTGGGTTCTTCCTGCATATT
AACTTGTTTGTAAGAAAGGAAATCTGTGCTGCTTCAGTAAGACTTAATTGTAAAACCATATAACTTGAGATTTAAGTCTTTGGGTTTTGT
TTTAATAAAACAGCATGTTTTCAGGTAGAGCTTAAACTAAATGATGTGTTTACTTAGTGCAGTTTCTGGTTATGAATATTATATTGCTAT
GTGTATATTATATGGACTCTTTAAAATGATTGACAGATTGGCAAATTCTTAAATCTTTGTACATTGTTGAGTCATATGTTCTTAGAGTTA
AATTTGTCTCAGATAAGAAAGTGTTAAAGCATTAGCCTGTGTCAAGTTCTTTGAGTGATACTAGTGAAACCAAATAGAAAACTATTGTTG
GATCATGATTTAGTCTTATGTACATTCACCCGAAGACAAAAATGGTACTTAAAGTGGCAGTGTTCAACATTTAATGAGTTTTTCCCCTTT
TATCCTTCGAATAGGATTAGATGTTTAAAAAAAAGTTCTTCTGTGGGAACTAATATTTGATATTTTAACCTACCAGAGTAAACAGGAACA
CTTAATCATACTTGTGAGTGTAGTAAATAAAAGTTTTCTTGCTTTGTGCTGTGTTGAATCTGGAACCAACAGGGAAGTTATAGCATATCC
CCTTTCTAAAATGCTTGAGGAACACATACATACCGAATGTCTTTTCTGATCTAATTGATAGTATTTTTAGTGGCTTGTGGAGTTAATTTT
CCAAAGCAAAAGGCCATTAGGGTTTCTACATTTCATTTCATTTCATTCTTTTCTTTCACAAGAAATACATTCTCTGTGTGTCTTTTTGTT
GCTCTGTCACTCTATGCCCTTTCTCTCCGACTGAACAAATAGCTTATCCATGTGCAGTGGTTTTAATACCCAAACAATCTAGACACCAAG
CAGCTATTTTTTCCGGTCCTGTGATATCAGAATTGACCAAGGAATACGTATATTGTAATTGACACGTGGTGGTATCTTCCAGGTACAAAT
TCTCTAAATTTTGTGGTTAGCAGAATGGGACTTGTGATAAGAATAGCTTGGTTTTAGCATAACTAGGGTTTAAAATAATTGTTTAATTAT
AGAGACTGACCGGGCTTTGGCCATCTAAACTGGAAAGTGTTAGTACCCTACCTTCTTTTGAAAATGGCTATGGTAAGGAAAATGTGTTAG
TAAATTATGTATTTTCTTGAAAAATACATAATTATGGTTGGATGGGAATCACTAAGTTGGGTGTTAACTGATGTCTCAATTAGTAACATT
AGGATTTTCATTAATAAACCTAAAAAGCTTTCCCTAAGAACAGGCCTGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACC
AGGGTGGGTGGATCCCTTGAGGTCAGGAGTTGAAGAGCAGCCTGGCCAACATGGCAAAACCCCATCTCTACAAAAAATATGAAAATCAGC
CGGGCTTGGTGGCATACCATAGTCCCAGCTACTTGGGAGGCTGAGGTGAGAGGATCGCCTGAGCCCAGGAGATGGAGGTTGCAGTGGGCT
GAGATTGTGCCACTGTACTCCAGTCTGGGTGACAGAGCCAGACCCTGTCTCAAAAATAAAGAGGATTCTGAGTTTGTATAGTGAGGGCTT
GCAGAAATTTTGAAACTTATTTTGTAAGTTTACAATGAATTTGTACATGATGTGCTCATGTCTTGGGTTGAGTATCCTAGACATGATTTT
TTCATTTGCTGCATATTAAACATTTGTTGGTTGTAGTCGGTATTTCTTAAATAGAAGTTTGTCAATATTAGATTAGTTTCAAGAAGGACT
TAGCTCAGGAAAAGGATAGTTATTTCTGTGGTTCTCAGCTTTGATGCCTACAGAGATTCTGATTTAAATTGCTGGAGGAGGGCCCAGGCA
TACATTTTTTAAGTTTCCCAAGTGATTCTAATTTACATCTAGGGTTAAAAACAGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACT
TGGGGAGGCCGGGGTGGGTGGATCACCTGATGTCAGGAGATCGAGACCAGCCTGGCCAGCGTGGTGAAACCCCATCTCTATTAAAAATAC
AAAACTGACCGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGAGGAGGT
TACAGTGAGCCCAGATCGTGCCATTGCACTCCAGCCTGGGCAAAAAGAGCAAAACTCCATCTCAAAAAACAAAAACACCTCACTGCTGTT
TCCTAAGTACATACTTAAGAAAATTGGGATACATGGTGGTGGTTCATGGATGTTGATAAGGAATTAAAATGTACCGTGCGACTCTCTGTT
TCAGTGGTGACTTTTACCTGTTTAGTATAAATATTCCTTTGCTTCCAACCATAAATGTGTTCTTAGAAATGGGCCTATAGTTTAGTAACC

>In-frame_ENST00000315872_ENST00000481195_TCGA-BH-A0HL_ROCK2_chr2_11484121_-_PPP2CA_chr5_133541822_length(amino acids)=322AA_start in transcript=449_stop in transcript=1417
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPD
TNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLH
GGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVV

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Fusion Gene PPI Analysis for ROCK2-PPP2CA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ROCK2	chr2:11484121	chr5:133541822	ENST00000315872	-	1	33	373_420	47.0	1389.0	NPM1
Hgene	ROCK2	chr2:11484122	chr5:133541822	ENST00000315872	-	1	33	373_420	47.0	1389.0	NPM1
Hgene	ROCK2	chr2:11484121	chr5:133541822	ENST00000315872	-	1	33	363_784	47.0	1389.0	PPP1R12A
Hgene	ROCK2	chr2:11484122	chr5:133541822	ENST00000315872	-	1	33	363_784	47.0	1389.0	PPP1R12A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ROCK2-PPP2CA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ROCK2-PPP2CA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ROCK2	C0018800	Cardiomegaly	1	CTD_human
Hgene	ROCK2	C0018801	Heart failure	1	CTD_human
Hgene	ROCK2	C0018802	Congestive heart failure	1	CTD_human
Hgene	ROCK2	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	ROCK2	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	ROCK2	C0600519	Ventricular Remodeling	1	CTD_human
Hgene	ROCK2	C0600520	Left Ventricle Remodeling	1	CTD_human
Hgene	ROCK2	C1383860	Cardiac Hypertrophy	1	CTD_human
Hgene	ROCK2	C1959583	Myocardial Failure	1	CTD_human
Hgene	ROCK2	C1961112	Heart Decompensation	1	CTD_human
Tgene	PPP2CA	C0004096	Asthma	1	CTD_human
Tgene	PPP2CA	C0018799	Heart Diseases	1	CTD_human
Tgene	PPP2CA	C0023015	Language Disorders	1	GENOMICS_ENGLAND
Tgene	PPP2CA	C0026827	Muscle hypotonia	1	GENOMICS_ENGLAND
Tgene	PPP2CA	C0036572	Seizures	1	GENOMICS_ENGLAND
Tgene	PPP2CA	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	PPP2CA	C0232466	Feeding difficulties	1	GENOMICS_ENGLAND
Tgene	PPP2CA	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Tgene	PPP2CA	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene	PPP2CA	C4022810	Abnormality of nervous system morphology	1	GENOMICS_ENGLAND