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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ROR1-ALG6 (FusionGDB2 ID:74885)

Fusion Gene Summary for ROR1-ALG6

check button Fusion gene summary
Fusion gene informationFusion gene name: ROR1-ALG6
Fusion gene ID: 74885
HgeneTgene
Gene symbol

ROR1

ALG6

Gene ID

6095

29929

Gene nameRAR related orphan receptor AALG6 alpha-1,3-glucosyltransferase
SynonymsIDDECA|NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRACDG1C
Cytomap

15q22.2

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4trandolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferaseMan(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferaseasparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)asparagine-linked glycosylation 6 homolog (yeast
Modification date2020032220200313
UniProtAcc.

Q9Y672

Ensembl transtripts involved in fusion geneENST00000371080, ENST00000371079, 
ENST00000482426, ENST00000545203, 
ENST00000371108, ENST00000263440, 
ENST00000494765, 
Fusion gene scores* DoF score15 X 10 X 7=10505 X 6 X 5=150
# samples 176
** MAII scorelog2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROR1 [Title/Abstract] AND ALG6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointROR1(64516388)-ALG6(63867924), # samples:1
ROR1(64516388)-ALG6(63902494), # samples:1
Anticipated loss of major functional domain due to fusion event.ROR1-ALG6 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ROR1-ALG6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ROR1-ALG6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ROR1-ALG6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROR1

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneROR1

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneROR1

GO:0036315

cellular response to sterol

19965867

HgeneROR1

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneROR1

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433

TgeneALG6

GO:0006487

protein N-linked glycosylation

10924277


check buttonFusion gene breakpoints across ROR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALG6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0765ROR1chr1

64516388

+ALG6chr1

63867924

+
ChimerDB4STADTCGA-HU-A4GN-01AROR1chr1

64516388

+ALG6chr1

63902494

+


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Fusion Gene ORF analysis for ROR1-ALG6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371080ENST00000371108ROR1chr1

64516388

+ALG6chr1

63867924

+
In-frameENST00000371080ENST00000263440ROR1chr1

64516388

+ALG6chr1

63867924

+
5CDS-intronENST00000371080ENST00000494765ROR1chr1

64516388

+ALG6chr1

63867924

+
In-frameENST00000371079ENST00000371108ROR1chr1

64516388

+ALG6chr1

63867924

+
In-frameENST00000371079ENST00000263440ROR1chr1

64516388

+ALG6chr1

63867924

+
5CDS-intronENST00000371079ENST00000494765ROR1chr1

64516388

+ALG6chr1

63867924

+
3UTR-3CDSENST00000482426ENST00000371108ROR1chr1

64516388

+ALG6chr1

63867924

+
3UTR-3CDSENST00000482426ENST00000263440ROR1chr1

64516388

+ALG6chr1

63867924

+
3UTR-intronENST00000482426ENST00000494765ROR1chr1

64516388

+ALG6chr1

63867924

+
intron-3CDSENST00000545203ENST00000371108ROR1chr1

64516388

+ALG6chr1

63867924

+
intron-3CDSENST00000545203ENST00000263440ROR1chr1

64516388

+ALG6chr1

63867924

+
intron-intronENST00000545203ENST00000494765ROR1chr1

64516388

+ALG6chr1

63867924

+
Frame-shiftENST00000371080ENST00000371108ROR1chr1

64516388

+ALG6chr1

63902494

+
In-frameENST00000371080ENST00000263440ROR1chr1

64516388

+ALG6chr1

63902494

+
5CDS-3UTRENST00000371080ENST00000494765ROR1chr1

64516388

+ALG6chr1

63902494

+
Frame-shiftENST00000371079ENST00000371108ROR1chr1

64516388

+ALG6chr1

63902494

+
In-frameENST00000371079ENST00000263440ROR1chr1

64516388

+ALG6chr1

63902494

+
5CDS-3UTRENST00000371079ENST00000494765ROR1chr1

64516388

+ALG6chr1

63902494

+
3UTR-3CDSENST00000482426ENST00000371108ROR1chr1

64516388

+ALG6chr1

63902494

+
3UTR-3CDSENST00000482426ENST00000263440ROR1chr1

64516388

+ALG6chr1

63902494

+
3UTR-3UTRENST00000482426ENST00000494765ROR1chr1

64516388

+ALG6chr1

63902494

+
intron-3CDSENST00000545203ENST00000371108ROR1chr1

64516388

+ALG6chr1

63902494

+
intron-3CDSENST00000545203ENST00000263440ROR1chr1

64516388

+ALG6chr1

63902494

+
intron-3UTRENST00000545203ENST00000494765ROR1chr1

64516388

+ALG6chr1

63902494

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371080ROR1chr164516388+ENST00000371108ALG6chr163867924+37778783572234625
ENST00000371080ROR1chr164516388+ENST00000263440ALG6chr163867924+23988783572240627
ENST00000371079ROR1chr164516388+ENST00000371108ALG6chr163867924+37568573362213625
ENST00000371079ROR1chr164516388+ENST00000263440ALG6chr163867924+23778573362219627
ENST00000371080ROR1chr164516388+ENST00000263440ALG6chr163902494+1233878357911184
ENST00000371079ROR1chr164516388+ENST00000263440ALG6chr163902494+1212857336890184

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371080ENST00000371108ROR1chr164516388+ALG6chr163867924+0.0011141870.9988858
ENST00000371080ENST00000263440ROR1chr164516388+ALG6chr163867924+0.0035342390.9964658
ENST00000371079ENST00000371108ROR1chr164516388+ALG6chr163867924+0.0010779780.9989221
ENST00000371079ENST00000263440ROR1chr164516388+ALG6chr163867924+0.003289530.9967104
ENST00000371080ENST00000263440ROR1chr164516388+ALG6chr163902494+0.078641320.9213587
ENST00000371079ENST00000263440ROR1chr164516388+ALG6chr163902494+0.058598090.94140184

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Fusion Genomic Features for ROR1-ALG6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ROR1chr164516388+ALG6chr163902493+0.0092321020.9907679
ROR1chr164516388+ALG6chr163867924+0.0066837030.99331635
ROR1chr164516388+ALG6chr163902493+0.0092321020.9907679
ROR1chr164516388+ALG6chr163867924+0.0066837030.99331635

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROR1-ALG6


check button Go to

FGviewer for the breakpoints of chr1:64516388-chr1:63867924

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ALG6

Q9Y672

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+4942_147160.66666666666666938.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+4742_147160.66666666666666394.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+4942_147160.66666666666666938.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+4742_147160.66666666666666394.0DomainNote=Ig-like C2-type
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215115_13555.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215144_16455.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215173_19355.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215227_24755.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215298_31855.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215324_34455.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215362_38255.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215388_40855.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215438_45855.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST00000371108215473_49355.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315473_493442.0508.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49753_782160.66666666666666938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49784_851160.66666666666666938.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49853_876160.66666666666666938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47753_782160.66666666666666394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47784_851160.66666666666666394.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47853_876160.66666666666666394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16753_7820389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16784_8510389.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16853_8760389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49753_782160.66666666666666938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49784_851160.66666666666666938.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49853_876160.66666666666666938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47753_782160.66666666666666394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47784_851160.66666666666666394.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47853_876160.66666666666666394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16753_7820389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16784_8510389.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16853_8760389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49165_299160.66666666666666938.0DomainFZ
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49312_391160.66666666666666938.0DomainKringle
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49473_746160.66666666666666938.0DomainProtein kinase
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47165_299160.66666666666666394.0DomainFZ
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47312_391160.66666666666666394.0DomainKringle
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47473_746160.66666666666666394.0DomainProtein kinase
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16165_2990389.0DomainFZ
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16312_3910389.0DomainKringle
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+1642_1470389.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16473_7460389.0DomainProtein kinase
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49165_299160.66666666666666938.0DomainFZ
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49312_391160.66666666666666938.0DomainKringle
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49473_746160.66666666666666938.0DomainProtein kinase
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47165_299160.66666666666666394.0DomainFZ
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47312_391160.66666666666666394.0DomainKringle
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47473_746160.66666666666666394.0DomainProtein kinase
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16165_2990389.0DomainFZ
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16312_3910389.0DomainKringle
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+1642_1470389.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16473_7460389.0DomainProtein kinase
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49479_487160.66666666666666938.0Nucleotide bindingATP
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47479_487160.66666666666666394.0Nucleotide bindingATP
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16479_4870389.0Nucleotide bindingATP
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49479_487160.66666666666666938.0Nucleotide bindingATP
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47479_487160.66666666666666394.0Nucleotide bindingATP
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16479_4870389.0Nucleotide bindingATP
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+4930_406160.66666666666666938.0Topological domainExtracellular
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49428_937160.66666666666666938.0Topological domainCytoplasmic
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+4730_406160.66666666666666394.0Topological domainExtracellular
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47428_937160.66666666666666394.0Topological domainCytoplasmic
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+1630_4060389.0Topological domainExtracellular
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16428_9370389.0Topological domainCytoplasmic
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+4930_406160.66666666666666938.0Topological domainExtracellular
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49428_937160.66666666666666938.0Topological domainCytoplasmic
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+4730_406160.66666666666666394.0Topological domainExtracellular
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47428_937160.66666666666666394.0Topological domainCytoplasmic
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+1630_4060389.0Topological domainExtracellular
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16428_9370389.0Topological domainCytoplasmic
HgeneROR1chr1:64516388chr1:63867924ENST00000371079+49407_427160.66666666666666938.0TransmembraneHelical
HgeneROR1chr1:64516388chr1:63867924ENST00000371080+47407_427160.66666666666666394.0TransmembraneHelical
HgeneROR1chr1:64516388chr1:63867924ENST00000545203+16407_4270389.0TransmembraneHelical
HgeneROR1chr1:64516388chr1:63902494ENST00000371079+49407_427160.66666666666666938.0TransmembraneHelical
HgeneROR1chr1:64516388chr1:63902494ENST00000371080+47407_427160.66666666666666394.0TransmembraneHelical
HgeneROR1chr1:64516388chr1:63902494ENST00000545203+16407_4270389.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63867924ENST000003711082154_2455.666666666666664508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315115_135442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315144_164442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315173_193442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315227_247442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315298_318442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315324_344442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315362_382442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315388_408442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST000003711081315438_458442.0508.0TransmembraneHelical
TgeneALG6chr1:64516388chr1:63902494ENST0000037110813154_24442.0508.0TransmembraneHelical


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Fusion Gene Sequence for ROR1-ALG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000371080_ENST00000371108_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(transcript)=3777nt_BP=878nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATTCTTACCTGACCCTCGATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCAC
TGCAAAGTCTCTGGGAATCCACCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGG
TCCACCATCTATGGCTCTCGGCTGCGGATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAG
GTGGTTTCTTCCACTGGAGTCTTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCGTATTTTAACAGCAGTGATAAC
AATTTACAGTATTGGGGATTGGATTACCCACCTCTTACAGCTTATCATAGTCTCCTATGTGCATATGTGGCAAAGTTTATAAATCCAGAC
TGGATTGCTCTCCATACATCACGTGGATATGAGAGTCAGGCACATAAGCTCTTCATGCGTACAACAGTTTTAATTGCTGATCTGCTGATT
TACATACCTGCAGTGGTTTTGTACTGTTGTTGCTTAAAAGAAATCTCAACTAAGAAAAAGATTGCTAATGCATTATGCATCTTGCTGTAT
CCAGGCCTTATTCTTATAGACTATGGACATTTTCAATATAATTCTGTGAGTCTTGGCTTTGCTTTGTGGGGTGTTCTTGGAATATCTTGT
GACTGCGACCTCCTAGGGTCACTGGCATTTTGCTTAGCTATAAATTATAAACAGATGGAACTTTACCACGCCTTGCCATTTTTTTGCTTT
TTACTTGGCAAGTGTTTTAAAAAAGGCCTCAAAGGAAAGGGGTTTGTGTTGCTAGTTAAGCTAGCTTGTATTGTTGTGGCTTCCTTCGTT
CTCTGCTGGCTGCCATTCTTTACAGAAAGGGAACAAACCCTGCAGGTTCTAAGAAGACTCTTCCCGGTTGATCGTGGATTATTTGAGGAT
AAAGTAGCCAATATTTGGTGCAGCTTCAATGTCTTTCTGAAGATTAAGGATATTTTGCCACGTCACATCCAATTAATAATGAGCTTTTGT
TCTACGTTTTTGAGCCTGCTTCCTGCATGCATAAAATTAATACTTCAGCCCTCTTCCAAAGGATTCAAATTTACACTGGTTAGCTGTGCG
CTATCATTCTTTTTATTTTCTTTCCAAGTACATGAAAAATCCATTCTCTTGGTGTCACTACCAGTCTGCTTAGTTTTAAGTGAAATTCCT
TTTATGTCTACTTGGTTTTTACTTGTGTCAACATTTAGTATGCTACCTCTTCTATTGAAGGATGAACTCCTAATGCCCTCTGTTGTGACA
ACAATGGCATTTTTTATAGCTTGTGTAACTTCCTTTTCAATATTTGAAAAGACTTCTGAAGAAGAACTGCAGTTGAAATCCTTTTCCATT
TCTGTGAGGAAATATCTTCCATGTTTTACATTTCTTTCCAGAATTATACAATATTTGTTTCTTATCTCAGTCATCACTATGGTGCTTCTG
ACGTTGATGACTGTCACACTGGATCCTCCTCAGAAACTACCGGACTTGTTTTCTGTATTGGTGTGTTTTGTATCTTGCTTGAACTTCCTG
TTCTTCTTGGTATACTTTAACATTATTATTATGTGGGATTCCAAAAGTGGAAGAAATCAGAAGAAAATCAGCTAGCTGTATTCCTAAACA
AATTGTTTCCTAAACAAATGTGAAAATGTGAACAGTGCTGAAAGGTTTTGTGAACTTTTTGCTATGTATAAATGAAATTACCATTTTGAG
AACCATGGAACCACAGGAAAGGAAATGGTGAAAAGTCATTGTTGTCTACACAAAATAAATGTATATGGAGACCAAAGACCAATGGAGGCT
TGTCTAAGTACTGCTTGGCCAAAACATGTGGTTTTATTATTCACAGCTATTCAAGTGGGGAAAAAAGAGAAACATGTCCTTAATCCCATT
GTTTACTCAGGAAATGCACTTTTTAAATGTCTTTAAAAAACTGAGAAATATTTCTTGATATTTGCTTTGTCTAAACCTACTTCCTTCATC
AGACCATATAGTGAGCTTCATGGGAGAATTGAGCCCCTTCTTTTTAATGGAAATCACTAATTTTGGTATTCAAACTTACATTTTAGAATG
CAAGTAGTGTGTATTTCACTGTTTAGAAGTCATATCTTAGGGAATTAAATTTGTGATAATCTTTTTAATTACTGAGAAGGCAATTTAAAC
TGCTTGAAGTTTGAATATGCCTTATTACACATGCAAATTTGATTGTTTTAACAAGGCAAATAAACCATAATCTTATTTATTTCCAAGAAT
GCATATTTTAATACAATTAAAAATGAATTTTCCTGAATTTAAATGTAAGCTTTAACTTAACTTTAAGTGGTTTGAGTGAAGTCTTCTAAA
TTACACATAATCACTGGTTCTAAACTTCCAGAACCATTCTGTTTAATTAAACATTATATTATATATATATTATTATTGACATGGTTCAGG
GTTACCACTGCCAGAGCATTGATTCATGTTAACTTCATCCTATTAATACTGTATCACCCTGTATTAGCAGAAGCCAATATTTATTATAGT
ATTCAACTGGTAAAAATAATACATGATATCCATGTTGCAGTTTCTCATATAAAGATATGTTTTCTTTAGCCTCTGTAATAAAGATAATCA
TTTTCCCATCAACATTTTTTAAGGAATATATTTCTTCTTTCATAAGATAGCCATTAAACTATATTAAGTGGTGGTATATTTTAATATAGT
GCAAATCAAACCACATACAAAAAAAAACTGGTTCTAGACACGGACAGTCACAGGCTGATATAAGAAGGTATGTGTTTCTAAGTCTGGTAA
AGGAAGTGGGTTTAGACAAAGCAAAAATCTAGAAAGGTTTCTTTCTCAAAGCAAATGTGCATAAAGACTCAAAGGGCAGGTCAACGCAGA
ATAGCAGCCTTGAATCACTGCCGAATCAGCAAGAACATTGCTGTCCATGGTCACCATCTGTAATCACTGTGCCCAAATGTCAGCATCTTG
GCTGGCTGGTGTAGCTTTATTTTTAAAAATATTTTTTGTAATAGTACACTTGTGTTTAACATAGAATGTTGACTTAGATAAATGATGAGG

>In-frame_ENST00000371080_ENST00000371108_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(amino acids)=625AA_start in transcript=357_stop in transcript=2234
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSYFNSSD
NNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILL
YPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASF
VLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSC
ALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFS

--------------------------------------------------------------
>In-frame_ENST00000371080_ENST00000263440_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(transcript)=2398nt_BP=878nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATTCTTACCTGACCCTCGATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCAC
TGCAAAGTCTCTGGGAATCCACCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGG
TCCACCATCTATGGCTCTCGGCTGCGGATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAG
GTGGTTTCTTCCACTGGAGTCTTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCGTATTTTAACAGCAGTGATAAC
AATTTACAGTATTGGGGATTGGATTACCCACCTCTTACAGCTTATCATAGTCTCCTATGTGCATATGTGGCAAAGTTTATAAATCCAGAC
TGGATTGCTCTCCATACATCACGTGGATATGAGAGTCAGGCACATAAGCTCTTCATGCGTACAACAGTTTTAATTGCTGATCTGCTGATT
TACATACCTGCAGTGGTTTTGTACTGTTGTTGCTTAAAAGAAATCTCAACTAAGAAAAAGATTGCTAATGCATTATGCATCTTGCTGTAT
CCAGGCCTTATTCTTATAGACTATGGACATTTTCAGAACATATATAATTCTGTGAGTCTTGGCTTTGCTTTGTGGGGTGTTCTTGGAATA
TCTTGTGACTGCGACCTCCTAGGGTCACTGGCATTTTGCTTAGCTATAAATTATAAACAGATGGAACTTTACCACGCCTTGCCATTTTTT
TGCTTTTTACTTGGCAAGTGTTTTAAAAAAGGCCTCAAAGGAAAGGGGTTTGTGTTGCTAGTTAAGCTAGCTTGTATTGTTGTGGCTTCC
TTCGTTCTCTGCTGGCTGCCATTCTTTACAGAAAGGGAACAAACCCTGCAGGTTCTAAGAAGACTCTTCCCGGTTGATCGTGGATTATTT
GAGGATAAAGTAGCCAATATTTGGTGCAGCTTCAATGTCTTTCTGAAGATTAAGGATATTTTGCCACGTCACATCCAATTAATAATGAGC
TTTTGTTCTACGTTTTTGAGCCTGCTTCCTGCATGCATAAAATTAATACTTCAGCCCTCTTCCAAAGGATTCAAATTTACACTGGTTAGC
TGTGCGCTATCATTCTTTTTATTTTCTTTCCAAGTACATGAAAAATCCATTCTCTTGGTGTCACTACCAGTCTGCTTAGTTTTAAGTGAA
ATTCCTTTTATGTCTACTTGGTTTTTACTTGTGTCAACATTTAGTATGCTACCTCTTCTATTGAAGGATGAACTCCTAATGCCCTCTGTT
GTGACAACAATGGCATTTTTTATAGCTTGTGTAACTTCCTTTTCAATATTTGAAAAGACTTCTGAAGAAGAACTGCAGTTGAAATCCTTT
TCCATTTCTGTGAGGAAATATCTTCCATGTTTTACATTTCTTTCCAGAATTATACAATATTTGTTTCTTATCTCAGTCATCACTATGGTG
CTTCTGACGTTGATGACTGTCACACTGGATCCTCCTCAGAAACTACCGGACTTGTTTTCTGTATTGGTGTGTTTTGTATCTTGCTTGAAC
TTCCTGTTCTTCTTGGTATACTTTAACATTATTATTATGTGGGATTCCAAAAGTGGAAGAAATCAGAAGAAAATCAGCTAGCTGTATTCC
TAAACAAATTGTTTCCTAAACAAATGTGAAAATGTGAACAGTGCTGAAAGGTTTTGTGAACTTTTTGCTATGTATAAATGAAATTACCAT

>In-frame_ENST00000371080_ENST00000263440_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(amino acids)=627AA_start in transcript=357_stop in transcript=2240
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSYFNSSD
NNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILL
YPGLILIDYGHFQNIYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVA
SFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLV
SCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKS

--------------------------------------------------------------
>In-frame_ENST00000371079_ENST00000371108_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(transcript)=3756nt_BP=857nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
TCTTACCTGACCCTCGATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCACTGCAAAGTCTCTGGGAATCCA
CCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGGTCCACCATCTATGGCTCTCGG
CTGCGGATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAGGTGGTTTCTTCCACTGGAGTC
TTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCGTATTTTAACAGCAGTGATAACAATTTACAGTATTGGGGATTG
GATTACCCACCTCTTACAGCTTATCATAGTCTCCTATGTGCATATGTGGCAAAGTTTATAAATCCAGACTGGATTGCTCTCCATACATCA
CGTGGATATGAGAGTCAGGCACATAAGCTCTTCATGCGTACAACAGTTTTAATTGCTGATCTGCTGATTTACATACCTGCAGTGGTTTTG
TACTGTTGTTGCTTAAAAGAAATCTCAACTAAGAAAAAGATTGCTAATGCATTATGCATCTTGCTGTATCCAGGCCTTATTCTTATAGAC
TATGGACATTTTCAATATAATTCTGTGAGTCTTGGCTTTGCTTTGTGGGGTGTTCTTGGAATATCTTGTGACTGCGACCTCCTAGGGTCA
CTGGCATTTTGCTTAGCTATAAATTATAAACAGATGGAACTTTACCACGCCTTGCCATTTTTTTGCTTTTTACTTGGCAAGTGTTTTAAA
AAAGGCCTCAAAGGAAAGGGGTTTGTGTTGCTAGTTAAGCTAGCTTGTATTGTTGTGGCTTCCTTCGTTCTCTGCTGGCTGCCATTCTTT
ACAGAAAGGGAACAAACCCTGCAGGTTCTAAGAAGACTCTTCCCGGTTGATCGTGGATTATTTGAGGATAAAGTAGCCAATATTTGGTGC
AGCTTCAATGTCTTTCTGAAGATTAAGGATATTTTGCCACGTCACATCCAATTAATAATGAGCTTTTGTTCTACGTTTTTGAGCCTGCTT
CCTGCATGCATAAAATTAATACTTCAGCCCTCTTCCAAAGGATTCAAATTTACACTGGTTAGCTGTGCGCTATCATTCTTTTTATTTTCT
TTCCAAGTACATGAAAAATCCATTCTCTTGGTGTCACTACCAGTCTGCTTAGTTTTAAGTGAAATTCCTTTTATGTCTACTTGGTTTTTA
CTTGTGTCAACATTTAGTATGCTACCTCTTCTATTGAAGGATGAACTCCTAATGCCCTCTGTTGTGACAACAATGGCATTTTTTATAGCT
TGTGTAACTTCCTTTTCAATATTTGAAAAGACTTCTGAAGAAGAACTGCAGTTGAAATCCTTTTCCATTTCTGTGAGGAAATATCTTCCA
TGTTTTACATTTCTTTCCAGAATTATACAATATTTGTTTCTTATCTCAGTCATCACTATGGTGCTTCTGACGTTGATGACTGTCACACTG
GATCCTCCTCAGAAACTACCGGACTTGTTTTCTGTATTGGTGTGTTTTGTATCTTGCTTGAACTTCCTGTTCTTCTTGGTATACTTTAAC
ATTATTATTATGTGGGATTCCAAAAGTGGAAGAAATCAGAAGAAAATCAGCTAGCTGTATTCCTAAACAAATTGTTTCCTAAACAAATGT
GAAAATGTGAACAGTGCTGAAAGGTTTTGTGAACTTTTTGCTATGTATAAATGAAATTACCATTTTGAGAACCATGGAACCACAGGAAAG
GAAATGGTGAAAAGTCATTGTTGTCTACACAAAATAAATGTATATGGAGACCAAAGACCAATGGAGGCTTGTCTAAGTACTGCTTGGCCA
AAACATGTGGTTTTATTATTCACAGCTATTCAAGTGGGGAAAAAAGAGAAACATGTCCTTAATCCCATTGTTTACTCAGGAAATGCACTT
TTTAAATGTCTTTAAAAAACTGAGAAATATTTCTTGATATTTGCTTTGTCTAAACCTACTTCCTTCATCAGACCATATAGTGAGCTTCAT
GGGAGAATTGAGCCCCTTCTTTTTAATGGAAATCACTAATTTTGGTATTCAAACTTACATTTTAGAATGCAAGTAGTGTGTATTTCACTG
TTTAGAAGTCATATCTTAGGGAATTAAATTTGTGATAATCTTTTTAATTACTGAGAAGGCAATTTAAACTGCTTGAAGTTTGAATATGCC
TTATTACACATGCAAATTTGATTGTTTTAACAAGGCAAATAAACCATAATCTTATTTATTTCCAAGAATGCATATTTTAATACAATTAAA
AATGAATTTTCCTGAATTTAAATGTAAGCTTTAACTTAACTTTAAGTGGTTTGAGTGAAGTCTTCTAAATTACACATAATCACTGGTTCT
AAACTTCCAGAACCATTCTGTTTAATTAAACATTATATTATATATATATTATTATTGACATGGTTCAGGGTTACCACTGCCAGAGCATTG
ATTCATGTTAACTTCATCCTATTAATACTGTATCACCCTGTATTAGCAGAAGCCAATATTTATTATAGTATTCAACTGGTAAAAATAATA
CATGATATCCATGTTGCAGTTTCTCATATAAAGATATGTTTTCTTTAGCCTCTGTAATAAAGATAATCATTTTCCCATCAACATTTTTTA
AGGAATATATTTCTTCTTTCATAAGATAGCCATTAAACTATATTAAGTGGTGGTATATTTTAATATAGTGCAAATCAAACCACATACAAA
AAAAAACTGGTTCTAGACACGGACAGTCACAGGCTGATATAAGAAGGTATGTGTTTCTAAGTCTGGTAAAGGAAGTGGGTTTAGACAAAG
CAAAAATCTAGAAAGGTTTCTTTCTCAAAGCAAATGTGCATAAAGACTCAAAGGGCAGGTCAACGCAGAATAGCAGCCTTGAATCACTGC
CGAATCAGCAAGAACATTGCTGTCCATGGTCACCATCTGTAATCACTGTGCCCAAATGTCAGCATCTTGGCTGGCTGGTGTAGCTTTATT
TTTAAAAATATTTTTTGTAATAGTACACTTGTGTTTAACATAGAATGTTGACTTAGATAAATGATGAGGAAGTTATAAATAATTGGAGTA

>In-frame_ENST00000371079_ENST00000371108_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(amino acids)=625AA_start in transcript=336_stop in transcript=2213
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSYFNSSD
NNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILL
YPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASF
VLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSC
ALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFS

--------------------------------------------------------------
>In-frame_ENST00000371079_ENST00000263440_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(transcript)=2377nt_BP=857nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
TCTTACCTGACCCTCGATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCACTGCAAAGTCTCTGGGAATCCA
CCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGGTCCACCATCTATGGCTCTCGG
CTGCGGATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAGGTGGTTTCTTCCACTGGAGTC
TTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCGTATTTTAACAGCAGTGATAACAATTTACAGTATTGGGGATTG
GATTACCCACCTCTTACAGCTTATCATAGTCTCCTATGTGCATATGTGGCAAAGTTTATAAATCCAGACTGGATTGCTCTCCATACATCA
CGTGGATATGAGAGTCAGGCACATAAGCTCTTCATGCGTACAACAGTTTTAATTGCTGATCTGCTGATTTACATACCTGCAGTGGTTTTG
TACTGTTGTTGCTTAAAAGAAATCTCAACTAAGAAAAAGATTGCTAATGCATTATGCATCTTGCTGTATCCAGGCCTTATTCTTATAGAC
TATGGACATTTTCAGAACATATATAATTCTGTGAGTCTTGGCTTTGCTTTGTGGGGTGTTCTTGGAATATCTTGTGACTGCGACCTCCTA
GGGTCACTGGCATTTTGCTTAGCTATAAATTATAAACAGATGGAACTTTACCACGCCTTGCCATTTTTTTGCTTTTTACTTGGCAAGTGT
TTTAAAAAAGGCCTCAAAGGAAAGGGGTTTGTGTTGCTAGTTAAGCTAGCTTGTATTGTTGTGGCTTCCTTCGTTCTCTGCTGGCTGCCA
TTCTTTACAGAAAGGGAACAAACCCTGCAGGTTCTAAGAAGACTCTTCCCGGTTGATCGTGGATTATTTGAGGATAAAGTAGCCAATATT
TGGTGCAGCTTCAATGTCTTTCTGAAGATTAAGGATATTTTGCCACGTCACATCCAATTAATAATGAGCTTTTGTTCTACGTTTTTGAGC
CTGCTTCCTGCATGCATAAAATTAATACTTCAGCCCTCTTCCAAAGGATTCAAATTTACACTGGTTAGCTGTGCGCTATCATTCTTTTTA
TTTTCTTTCCAAGTACATGAAAAATCCATTCTCTTGGTGTCACTACCAGTCTGCTTAGTTTTAAGTGAAATTCCTTTTATGTCTACTTGG
TTTTTACTTGTGTCAACATTTAGTATGCTACCTCTTCTATTGAAGGATGAACTCCTAATGCCCTCTGTTGTGACAACAATGGCATTTTTT
ATAGCTTGTGTAACTTCCTTTTCAATATTTGAAAAGACTTCTGAAGAAGAACTGCAGTTGAAATCCTTTTCCATTTCTGTGAGGAAATAT
CTTCCATGTTTTACATTTCTTTCCAGAATTATACAATATTTGTTTCTTATCTCAGTCATCACTATGGTGCTTCTGACGTTGATGACTGTC
ACACTGGATCCTCCTCAGAAACTACCGGACTTGTTTTCTGTATTGGTGTGTTTTGTATCTTGCTTGAACTTCCTGTTCTTCTTGGTATAC
TTTAACATTATTATTATGTGGGATTCCAAAAGTGGAAGAAATCAGAAGAAAATCAGCTAGCTGTATTCCTAAACAAATTGTTTCCTAAAC
AAATGTGAAAATGTGAACAGTGCTGAAAGGTTTTGTGAACTTTTTGCTATGTATAAATGAAATTACCATTTTGAGAACCATGGAACCACA

>In-frame_ENST00000371079_ENST00000263440_TCGA-13-0765_ROR1_chr1_64516388_+_ALG6_chr1_63867924_length(amino acids)=627AA_start in transcript=336_stop in transcript=2219
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSYFNSSD
NNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILL
YPGLILIDYGHFQNIYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVA
SFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLV
SCALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKS

--------------------------------------------------------------
>In-frame_ENST00000371080_ENST00000263440_TCGA-HU-A4GN-01A_ROR1_chr1_64516388_+_ALG6_chr1_63902494_length(transcript)=1233nt_BP=878nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATTCTTACCTGACCCTCGATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCAC
TGCAAAGTCTCTGGGAATCCACCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGG
TCCACCATCTATGGCTCTCGGCTGCGGATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAG
GTGGTTTCTTCCACTGGAGTCTTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCTTTCTTATCTCAGTCATCACTA
TGGTGCTTCTGACGTTGATGACTGTCACACTGGATCCTCCTCAGAAACTACCGGACTTGTTTTCTGTATTGGTGTGTTTTGTATCTTGCT
TGAACTTCCTGTTCTTCTTGGTATACTTTAACATTATTATTATGTGGGATTCCAAAAGTGGAAGAAATCAGAAGAAAATCAGCTAGCTGT
ATTCCTAAACAAATTGTTTCCTAAACAAATGTGAAAATGTGAACAGTGCTGAAAGGTTTTGTGAACTTTTTGCTATGTATAAATGAAATT

>In-frame_ENST00000371080_ENST00000263440_TCGA-HU-A4GN-01A_ROR1_chr1_64516388_+_ALG6_chr1_63902494_length(amino acids)=184AA_start in transcript=357_stop in transcript=911
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSFLSQSS

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>In-frame_ENST00000371079_ENST00000263440_TCGA-HU-A4GN-01A_ROR1_chr1_64516388_+_ALG6_chr1_63902494_length(transcript)=1212nt_BP=857nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
TCTTACCTGACCCTCGATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCACTGCAAAGTCTCTGGGAATCCA
CCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGGTCCACCATCTATGGCTCTCGG
CTGCGGATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAGGTGGTTTCTTCCACTGGAGTC
TTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCTTTCTTATCTCAGTCATCACTATGGTGCTTCTGACGTTGATGA
CTGTCACACTGGATCCTCCTCAGAAACTACCGGACTTGTTTTCTGTATTGGTGTGTTTTGTATCTTGCTTGAACTTCCTGTTCTTCTTGG
TATACTTTAACATTATTATTATGTGGGATTCCAAAAGTGGAAGAAATCAGAAGAAAATCAGCTAGCTGTATTCCTAAACAAATTGTTTCC
TAAACAAATGTGAAAATGTGAACAGTGCTGAAAGGTTTTGTGAACTTTTTGCTATGTATAAATGAAATTACCATTTTGAGAACCATGGAA

>In-frame_ENST00000371079_ENST00000263440_TCGA-HU-A4GN-01A_ROR1_chr1_64516388_+_ALG6_chr1_63902494_length(amino acids)=184AA_start in transcript=336_stop in transcript=890
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSFLSQSS

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Fusion Gene PPI Analysis for ROR1-ALG6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ROR1-ALG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ROR1-ALG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneROR1C0005586Bipolar Disorder1PSYGENET
HgeneROR1C0006142Malignant neoplasm of breast1CTD_human;UNIPROT
HgeneROR1C0027627Neoplasm Metastasis1CTD_human
HgeneROR1C0678222Breast Carcinoma1CTD_human
HgeneROR1C1257931Mammary Neoplasms, Human1CTD_human
HgeneROR1C1458155Mammary Neoplasms1CTD_human
HgeneROR1C3711374Nonsyndromic Deafness1CLINGEN
HgeneROR1C4539997DEAFNESS, AUTOSOMAL RECESSIVE 1081GENOMICS_ENGLAND;UNIPROT
HgeneROR1C4704874Mammary Carcinoma, Human1CTD_human
TgeneALG6C2930997Congenital disorder of glycosylation type 1C8CTD_human;GENOMICS_ENGLAND;UNIPROT