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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF3-SNX1 (FusionGDB2 ID:7506)

Fusion Gene Summary for ATF3-SNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF3-SNX1
Fusion gene ID: 7506
HgeneTgene
Gene symbol

ATF3

SNX1

Gene ID

467

6642

Gene nameactivating transcription factor 3sorting nexin 1
Synonyms-HsT17379|VPS5
Cytomap

1q32.3

15q22.31

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-3cAMP-dependent transcription factor ATF-3sorting nexin-1sorting nexin 1A
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000366987, ENST00000341491, 
ENST00000366985, ENST00000492118, 
ENST00000336937, ENST00000366983, 
ENST00000560829, ENST00000353874, 
ENST00000261889, ENST00000559844, 
ENST00000561026, ENST00000559339, 
Fusion gene scores* DoF score3 X 2 X 3=1811 X 8 X 6=528
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF3 [Title/Abstract] AND SNX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF3(212791575)-SNX1(64426920), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF3

GO:0000122

negative regulation of transcription by RNA polymerase II

8622660

HgeneATF3

GO:0045944

positive regulation of transcription by RNA polymerase II

16300731

HgeneATF3

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

24939851

TgeneSNX1

GO:0072673

lamellipodium morphogenesis

20604901


check buttonFusion gene breakpoints across ATF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SNX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW998144ATF3chr1

212791575

+SNX1chr15

64426920

+
ChiTaRS5.0N/AAW998147ATF3chr1

212791575

+SNX1chr15

64426920

+


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Fusion Gene ORF analysis for ATF3-SNX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366987ENST00000560829ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366987ENST00000353874ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366987ENST00000261889ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366987ENST00000559844ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366987ENST00000561026ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366987ENST00000559339ATF3chr1

212791575

+SNX1chr15

64426920

+
In-frameENST00000341491ENST00000560829ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000341491ENST00000353874ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000341491ENST00000261889ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000341491ENST00000559844ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000341491ENST00000561026ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000341491ENST00000559339ATF3chr1

212791575

+SNX1chr15

64426920

+
In-frameENST00000366985ENST00000560829ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366985ENST00000353874ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366985ENST00000261889ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366985ENST00000559844ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366985ENST00000561026ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366985ENST00000559339ATF3chr1

212791575

+SNX1chr15

64426920

+
intron-3CDSENST00000492118ENST00000560829ATF3chr1

212791575

+SNX1chr15

64426920

+
intron-intronENST00000492118ENST00000353874ATF3chr1

212791575

+SNX1chr15

64426920

+
intron-intronENST00000492118ENST00000261889ATF3chr1

212791575

+SNX1chr15

64426920

+
intron-intronENST00000492118ENST00000559844ATF3chr1

212791575

+SNX1chr15

64426920

+
intron-intronENST00000492118ENST00000561026ATF3chr1

212791575

+SNX1chr15

64426920

+
intron-intronENST00000492118ENST00000559339ATF3chr1

212791575

+SNX1chr15

64426920

+
In-frameENST00000336937ENST00000560829ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000336937ENST00000353874ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000336937ENST00000261889ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000336937ENST00000559844ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000336937ENST00000561026ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000336937ENST00000559339ATF3chr1

212791575

+SNX1chr15

64426920

+
In-frameENST00000366983ENST00000560829ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366983ENST00000353874ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366983ENST00000261889ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366983ENST00000559844ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366983ENST00000561026ATF3chr1

212791575

+SNX1chr15

64426920

+
5CDS-intronENST00000366983ENST00000559339ATF3chr1

212791575

+SNX1chr15

64426920

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366987ATF3chr1212791575+ENST00000560829SNX1chr1564426920+1159481133582149
ENST00000341491ATF3chr1212791575+ENST00000560829SNX1chr1564426920+1291613235714159
ENST00000366985ATF3chr1212791575+ENST00000560829SNX1chr1564426920+9402623680123
ENST00000336937ATF3chr1212791575+ENST00000560829SNX1chr1564426920+9392610362120
ENST00000366983ATF3chr1212791575+ENST00000560829SNX1chr1564426920+10263480449149

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366987ENST00000560829ATF3chr1212791575+SNX1chr1564426920+0.193528970.80647105
ENST00000341491ENST00000560829ATF3chr1212791575+SNX1chr1564426920+0.372852390.6271476
ENST00000366985ENST00000560829ATF3chr1212791575+SNX1chr1564426920+0.100530520.8994695
ENST00000336937ENST00000560829ATF3chr1212791575+SNX1chr1564426920+0.3991570.600843
ENST00000366983ENST00000560829ATF3chr1212791575+SNX1chr1564426920+0.228557750.77144223

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Fusion Genomic Features for ATF3-SNX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATF3-SNX1


check button Go to

FGviewer for the breakpoints of chr1:212791575-chr15:64426920

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF3chr1:212791575chr15:64426920ENST00000341491+3488_110116.0182.0RegionBasic motif
HgeneATF3chr1:212791575chr15:64426920ENST00000366983+2388_110116.0136.0RegionBasic motif
HgeneATF3chr1:212791575chr15:64426920ENST00000366987+3488_110116.0182.0RegionBasic motif
TgeneSNX1chr1:212791575chr15:64426920ENST00000261889015143_2720558.0DomainPX
TgeneSNX1chr1:212791575chr15:64426920ENST00000261889015302_5220558.0DomainNote=BAR
TgeneSNX1chr1:212791575chr15:64426920ENST00000559844015143_2720523.0DomainPX
TgeneSNX1chr1:212791575chr15:64426920ENST00000559844015302_5220523.0DomainNote=BAR
TgeneSNX1chr1:212791575chr15:64426920ENST00000561026013143_2720.0458.0DomainPX
TgeneSNX1chr1:212791575chr15:64426920ENST00000561026013302_5220.0458.0DomainNote=BAR
TgeneSNX1chr1:212791575chr15:64426920ENST00000261889015281_2980558.0RegionMembrane-binding amphipathic helix
TgeneSNX1chr1:212791575chr15:64426920ENST00000559844015281_2980523.0RegionMembrane-binding amphipathic helix
TgeneSNX1chr1:212791575chr15:64426920ENST00000561026013281_2980.0458.0RegionMembrane-binding amphipathic helix

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF3chr1:212791575chr15:64426920ENST00000336937+3486_14987.0107.0DomainbZIP
HgeneATF3chr1:212791575chr15:64426920ENST00000341491+3486_149116.0182.0DomainbZIP
HgeneATF3chr1:212791575chr15:64426920ENST00000366983+2386_149116.0136.0DomainbZIP
HgeneATF3chr1:212791575chr15:64426920ENST00000366985+4586_14959.0125.0DomainbZIP
HgeneATF3chr1:212791575chr15:64426920ENST00000366987+3486_149116.0182.0DomainbZIP
HgeneATF3chr1:212791575chr15:64426920ENST00000336937+34114_14287.0107.0RegionLeucine-zipper
HgeneATF3chr1:212791575chr15:64426920ENST00000336937+3488_11087.0107.0RegionBasic motif
HgeneATF3chr1:212791575chr15:64426920ENST00000341491+34114_142116.0182.0RegionLeucine-zipper
HgeneATF3chr1:212791575chr15:64426920ENST00000366983+23114_142116.0136.0RegionLeucine-zipper
HgeneATF3chr1:212791575chr15:64426920ENST00000366985+45114_14259.0125.0RegionLeucine-zipper
HgeneATF3chr1:212791575chr15:64426920ENST00000366985+4588_11059.0125.0RegionBasic motif
HgeneATF3chr1:212791575chr15:64426920ENST00000366987+34114_142116.0182.0RegionLeucine-zipper


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Fusion Gene Sequence for ATF3-SNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366987_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(transcript)=1159nt_BP=481nt
AGTTGACCAACCATGCCTTGAGGATAAATTGGATGGGATCAGATGGGAAGATGTGACAAGAAGAGAAATCCTCCTCTATATAGGATGCTC
TGCTGTTTCCTAAGGATTTTCAGCACCTTGCCCCAAAATCAAAATGATGCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGTGAGTGC
TTCTGCCATCGTCCCCTGCCTGTCCCCTCCTGGGTCACTGGTGTTTGAGGATTTTGCTAACCTGACGCCCTTTGTCAAGGAAGAGCTGAG
GTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCCTCTGCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCAT
CACAAAAGCCGAGGTAGCCCCTGAAGAAGATGAAAGGAAAAAGAGGCGACGAGAAAGAAATAAGATTGCAGCTGCAAAGTGCCGAAACAA
GAAGAAGGAGAAGACGGAGTGCCTGCAGAAATGCAGAAGAAGCGGGAGGCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTG
CAGCAGGCCAAGGACGAGATCCTCGAGTGGGAGTCTCGGGTGACTCAATATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAA
GAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGACTTCAAGAACCACGTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAG
CTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGGCCATCTCCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCC
TTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAGTGATGCATCCTGCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACG
ACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTAGCTTCCATATATATTTTCTTACCTAAGAGAATAGTTTCCTGCTTTAAGCAA
AAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGGAGTATTGATATAAATATATAAATACAAATGTATATTTTTCAGGATGTGGTT

>In-frame_ENST00000366987_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(amino acids)=149AA_start in transcript=133_stop in transcript=582
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKK

--------------------------------------------------------------
>In-frame_ENST00000341491_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(transcript)=1291nt_BP=613nt
ATTACGTCAGCCTGGGACTGGCAACACGGAGTAAACGACCGCGCCGCCAGCCTGAGGGCTATAAAAGGGGTGATGCAACGCTCTCCAAGC
CACAGTCGCACGCAGCCAGGCGCGCACTGCACAGCTCTCTTCTCTCGCCGCCGCCCGAGCGCACCCTTCAGCCCGCGCGCCGGCCGTGAG
TCCTCGGTGCTCGCCCGCCGGCCAGACAAACAGCCCGCCCGACCCCGTCCCGACCCTGGCCGCCCCGAGCGGAGCCTGGAGCAAAATGAT
GCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGTGAGTGCTTCTGCCATCGTCCCCTGCCTGTCCCCTCCTGGGTCACTGGTGTTTGA
GGATTTTGCTAACCTGACGCCCTTTGTCAAGGAAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCCTCTGCGCT
GGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAGGTAGCCCCTGAAGAAGATGAAAGGAAAAAGAGGCG
ACGAGAAAGAAATAAGATTGCAGCTGCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAATGCAGAAGAAGCGGGAG
GCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTGCAGCAGGCCAAGGACGAGATCCTCGAGTGGGAGTCTCGGGTGACTCAA
TATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGACTTCAAGAACCAC
GTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGGCCATCTCC
TAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCCTTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAGTGATGCAT
CCTGCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTAGCTTCCATA
TATATTTTCTTACCTAAGAGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGGAGTATTGAT
ATAAATATATAAATACAAATGTATATTTTTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACTCCTGATGGTGCCATGAAA

>In-frame_ENST00000341491_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(amino acids)=159AA_start in transcript=235_stop in transcript=714
MAAPSGAWSKMMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAE

--------------------------------------------------------------
>In-frame_ENST00000366985_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(transcript)=940nt_BP=262nt
CGAGCGGAGCCTGGAGCAAAATGATGCTTCAACACCCAGGCCAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTC
CTCTGCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAGGTAGCCCCTGAAGAAGATGAAAGGAA
AAAGAGGCGACGAGAAAGAAATAAGATTGCAGCTGCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAATGCAGAAG
AAGCGGGAGGCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTGCAGCAGGCCAAGGACGAGATCCTCGAGTGGGAGTCTCGG
GTGACTCAATATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGACTTC
AAGAACCACGTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAG
GCCATCTCCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCCTTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTA
GTGATGCATCCTGCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTA
GCTTCCATATATATTTTCTTACCTAAGAGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGG
AGTATTGATATAAATATATAAATACAAATGTATATTTTTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACTCCTGATGGT

>In-frame_ENST00000366985_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(amino acids)=123AA_start in transcript=368_stop in transcript=0
MSHPRLPLEDLVLGLLQLIRLVGPQQPSLGLPLLLHFCRHSVFSFFLFRHFAAAILFLSRRLFFLSSSSGATSAFVMDTPRGLSLTVTDS

--------------------------------------------------------------
>In-frame_ENST00000336937_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(transcript)=939nt_BP=261nt
ATGATGCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGAAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCC
TCTGCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAGGTAGCCCCTGAAGAAGATGAAAGGAAA
AAGAGGCGACGAGAAAGAAATAAGATTGCAGCTGCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAATGCAGAAGA
AGCGGGAGGCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTGCAGCAGGCCAAGGACGAGATCCTCGAGTGGGAGTCTCGGG
TGACTCAATATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGACTTCA
AGAACCACGTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGG
CCATCTCCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCCTTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAG
TGATGCATCCTGCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTAG
CTTCCATATATATTTTCTTACCTAAGAGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGGA
GTATTGATATAAATATATAAATACAAATGTATATTTTTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACTCCTGATGGTG

>In-frame_ENST00000336937_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(amino acids)=120AA_start in transcript=0_stop in transcript=362
MMLQHPGQVSASEEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKCRR

--------------------------------------------------------------
>In-frame_ENST00000366983_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(transcript)=1026nt_BP=348nt
ATGATGCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGTGAGTGCTTCTGCCATCGTCCCCTGCCTGTCCCCTCCTGGGTCACTGGTG
TTTGAGGATTTTGCTAACCTGACGCCCTTTGTCAAGGAAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCCTCT
GCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAGGTAGCCCCTGAAGAAGATGAAAGGAAAAAG
AGGCGACGAGAAAGAAATAAGATTGCAGCTGCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAATGCAGAAGAAGC
GGGAGGCCGAGGCTCGGCTGCTGTGGGCCAACAAGCCTGATAAGCTGCAGCAGGCCAAGGACGAGATCCTCGAGTGGGAGTCTCGGGTGA
CTCAATATGAAAGGGACTTCGAGAGGATTTCAACAGTGGTCCGAAAAGAAGTGATACGGTTTGAGAAAGAGAAATCCAAGGACTTCAAGA
ACCACGTGATCAAGTACCTTGAGACACTCCTTTACTCACAGCAGCAGCTGGCAAAGTACTGGGAAGCCTTCCTTCCTGAGGCAAAGGCCA
TCTCCTAATGGACCAAGGACCCCAGAGCCCACCTGTGTGACGCTGCCTTTTTATACACTGTCCTCCTCCACCTTGATGGACCCCTAGTGA
TGCATCCTGCCTAGGCTGGACTTAACCCCTTCCTCCCTGTCCCCACGACCAACTGTCCCCAGTTACTCTAACCGTTATTTCATTTAGCTT
CCATATATATTTTCTTACCTAAGAGAATAGTTTCCTGCTTTAAGCAAAAGACCTACAATAGGTGGTGGAATTATGGGATGGGGTGGAGTA
TTGATATAAATATATAAATACAAATGTATATTTTTCAGGATGTGGTTTAGGAACTGGGAATAACGTTTTCTGTTACTCCTGATGGTGCCA

>In-frame_ENST00000366983_ENST00000560829_AW998144_ATF3_chr1_212791575_+_SNX1_chr15_64426920_length(amino acids)=149AA_start in transcript=0_stop in transcript=449
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKK

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Fusion Gene PPI Analysis for ATF3-SNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF3-SNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF3-SNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATF3C0027765nervous system disorder2CTD_human
HgeneATF3C0002152Alloxan Diabetes1CTD_human
HgeneATF3C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneATF3C0011570Mental Depression1PSYGENET
HgeneATF3C0011581Depressive disorder1PSYGENET
HgeneATF3C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneATF3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneATF3C0021400Influenza1CTD_human
HgeneATF3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneATF3C0023903Liver neoplasms1CTD_human
HgeneATF3C0033141Cardiomyopathies, Primary1CTD_human
HgeneATF3C0033578Prostatic Neoplasms1CTD_human
HgeneATF3C0036529Myocardial Diseases, Secondary1CTD_human
HgeneATF3C0038433Streptozotocin Diabetes1CTD_human
HgeneATF3C0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneATF3C0345904Malignant neoplasm of liver1CTD_human
HgeneATF3C0376358Malignant neoplasm of prostate1CTD_human
HgeneATF3C0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneATF3C0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneATF3C0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneATF3C0751845Middle Cerebral Artery Embolus1CTD_human
HgeneATF3C0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneATF3C0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneATF3C0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneATF3C0751849Right Middle Cerebral Artery Infarction1CTD_human
HgeneATF3C0848558Hypospadias1CTD_human
HgeneATF3C0878544Cardiomyopathies1CTD_human
HgeneATF3C0919267ovarian neoplasm1CTD_human
HgeneATF3C1140680Malignant neoplasm of ovary1CTD_human
HgeneATF3C4721453Peripheral Nervous System Diseases1CTD_human