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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATF6-STX6 (FusionGDB2 ID:7535)

Fusion Gene Summary for ATF6-STX6

Fusion gene summary

Fusion gene information	Fusion gene name: ATF6-STX6
	Fusion gene ID: 7535
		Hgene	Tgene
	Gene symbol	ATF6	STX6
	Gene ID	22926	10228
	Gene name	activating transcription factor 6	syntaxin 6
	Synonyms	ACHM7\|ATF6A	-
	Cytomap	1q23.3	1q25.3
	Type of gene	protein-coding	protein-coding
	Description	cyclic AMP-dependent transcription factor ATF-6 alphacAMP-dependent transcription factor ATF-6 alpha	syntaxin-6
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000367942, ENST00000476437,	ENST00000258301, ENST00000469135, ENST00000542060,
Fusion gene scores	* DoF score	12 X 10 X 8=960	3 X 3 X 3=27
	# samples	12	3
	** MAII score	log2(12/960*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ATF6 [Title/Abstract] AND STX6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATF6(161772062)-STX6(180962561), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATF6	GO:0043065	positive regulation of apoptotic process	14752510
Hgene	ATF6	GO:0045944	positive regulation of transcription by RNA polymerase II	14973138
Hgene	ATF6	GO:1903893	positive regulation of ATF6-mediated unfolded protein response	9837962
Hgene	ATF6	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	11163209\|11256944\|16469704

Fusion gene breakpoints across ATF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STX6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A49M	ATF6	chr1	161772062	+	STX6	chr1	180962561	-
ChimerDB4	ESCA	TCGA-LN-A49M	ATF6	chr1	161772062	+	STX6	chr1	180962561	-

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Fusion Gene ORF analysis for ATF6-STX6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000367942	ENST00000258301	ATF6	chr1	161772062	+	STX6	chr1	180962561	-
5CDS-intron	ENST00000367942	ENST00000469135	ATF6	chr1	161772062	+	STX6	chr1	180962561	-
5CDS-5UTR	ENST00000367942	ENST00000542060	ATF6	chr1	161772062	+	STX6	chr1	180962561	-
intron-3CDS	ENST00000476437	ENST00000258301	ATF6	chr1	161772062	+	STX6	chr1	180962561	-
intron-intron	ENST00000476437	ENST00000469135	ATF6	chr1	161772062	+	STX6	chr1	180962561	-
intron-5UTR	ENST00000476437	ENST00000542060	ATF6	chr1	161772062	+	STX6	chr1	180962561	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000367942

ATF6

chr1

161772062

ENST00000258301

STX6

chr1

180962561

5289

976

1443

477

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367942	ENST00000258301	ATF6	chr1	161772062	+	STX6	chr1	180962561	-	0.000383763	0.99961627

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Fusion Genomic Features for ATF6-STX6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATF6-STX6

Go to
FGviewer for the breakpoints of chr1:161772062-chr1:180962561
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

124_127

303.0

671.0

Compositional bias

Note=Poly-Ser

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

1_150

303.0

671.0

Region

Transcription activation

Tgene

STX6

chr1:161772062

chr1:180962561

ENST00000258301

163_225

100.0

256.0

Domain

t-SNARE coiled-coil homology

Tgene

STX6

chr1:161772062

chr1:180962561

ENST00000258301

235_255

100.0

256.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

325_328

303.0

671.0

Compositional bias

Note=Poly-Lys

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

463_466

303.0

671.0

Compositional bias

Note=Poly-Pro

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

306_369

303.0

671.0

Domain

bZIP

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

308_339

303.0

671.0

Region

Note=Basic motif

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

348_355

303.0

671.0

Region

Note=Leucine-zipper

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

1_377

303.0

671.0

Topological domain

Cytoplasmic

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

399_670

303.0

671.0

Topological domain

Lumenal

Hgene

ATF6

chr1:161772062

chr1:180962561

ENST00000367942

378_398

303.0

671.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

STX6

chr1:161772062

chr1:180962561

ENST00000258301

41_74

100.0

256.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STX6

chr1:161772062

chr1:180962561

ENST00000258301

2_234

100.0

256.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for ATF6-STX6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000367942_ENST00000258301_TCGA-LN-A49M_ATF6_chr1_161772062_+_STX6_chr1_180962561_length(transcript)=5289nt_BP=976nt
TTTTGTCCGCCTGCCGCCGCCGTCCCAGATATTAATCACGGAGTTCCAGGGAGAAGGAACTTGTGAAATGGGGGAGCCGGCTGGGGTTGC
CGGCACCATGGAGTCACCTTTTAGCCCGGGACTCTTTCACAGGCTGGATGAAGATTGGGATTCTGCTCTCTTTGCTGAACTCGGTTATTT
CACAGACACTGATGAGCTGCAATTGGAAGCAGCAAATGAGACGTATGAAAACAATTTTGATAATCTTGATTTTGATTTGGATTTGATGCC
TTGGGAGTCAGACATTTGGGACATCAACAACCAAATCTGTACAGTTAAAGATATTAAGGCAGAACCTCAGCCACTTTCTCCAGCCTCCTC
AAGTTATTCAGTCTCGTCTCCTCGGTCAGTGGACTCTTATTCTTCAACTCAGCATGTTCCTGAGGAGTTGGATTTGTCTTCTAGTTCTCA
GATGTCTCCCCTTTCCTTATATGGTGAAAACTCTAATAGTCTCTCTTCAGCGGAGCCACTGAAGGAAGATAAGCCTGTCACTGGTCCTAG
GAACAAGACTGAAAATGGACTGACTCCAAAGAAAAAAATTCAGGTGAATTCAAAACCTTCAATTCAGCCCAAGCCTTTATTGCTTCCAGC
AGCACCCAAGACTCAAACAAACTCCAGTGTTCCAGCAAAAACCATCATTATTCAGACAGTACCAACGCTTATGCCATTGGCAAAGCAGCA
ACCAATTATCAGTTTACAACCTGCACCCACTAAAGGCCAGACGGTTTTGCTGTCTCAGCCTACTGTGGTACAACTTCAAGCACCTGGAGT
TCTGCCCTCTGCTCAGCCAGTCCTTGCTGTTGCTGGGGGAGTCACACAGCTCCCTAATCACGTGGTGAATGTGGTACCAGCCCCTTCAGC
GAATAGCCCAGTGAATGGAAAACTTTCCGTGACTAAACCTGTCCTACAAAGTACCATGAGAAATGTCGGTTCAGATGACATGAAAGATCA
GATGTCAACTTCATCTGTGCAGGCATTAGCTGAAAGAAAAAATAGACAGGCACTGCTGGGAGACAGTGGCAGCCAGAACTGGAGCACTGG
AACAACAGATAAATATGGGCGTCTGGACCGAGAGCTCCAGAGAGCCAATTCTCATTTCATTGAGGAGCAGCAGGCACAGCAGCAGTTGAT
CGTGGAACAGCAGGATGAGCAGTTGGAGCTGGTCTCTGGCAGCATCGGGGTGCTGAAGAACATGTCCCAGCGCATCGGAGGGGAGCTGGA
GGAACAGGCAGTTATGTTGGAAGATTTCTCTCACGAATTGGAGAGCACTCAGTCCCGGCTGGACAATGTGATGAAGAAACTTGCAAAAGT
ATCTCATATGACCAGTGATCGGCGCCAATGGTGTGCCATAGCCATCCTCTTTGCAGTCCTGTTGGTTGTGCTCATCCTCTTCTTAGTGCT
GTGACGGCGGGGCCTCTGGGTGCGAGTTCCTCCTGCATATGAACCGAGGGGAGGAGGAGAAGCTGAGCACGTGTGACATTGCCGTCTACT
CACATTCCTATCCTGGAAACATACTGCTGCACTGACTTTTCTCCGTGTGACCCCACAATTGACATGGCTCCTCCATCCCAGCGCTGGAAG
GGCCAGTGGGAAGAGGAAATAGATGTCTGCACTCCTGGCTGCAGCTGGACAACAGAAGCCCCATGCCGCCTGTCCAGTTCGGAGGAGAAC
TAGCTGCTGCCTTGCCTTCCGGGACCTCGTTTGCTGAGGAGGGACTTACAGACTCCACTGGTGTTTTGCTGTTGCTCATTCCATGCATCT
TTGGCAGCTCTTTTCTTCTGCTCAGACCCTTCCCCGTGCTCAGACAGTGCACCGCTGTCCCATCTAAAGAAACCTGTCAGGAATACGAGC
TTCTGGGTATGTTTCGTTTCCCATTGCTGTAGCATTTCTTATCCCCTGAGAGCTGATGATTATTGAGGACAGAAGGCTCAGAAACAGTTT
GTGACAGAAAATGCAGTGTTTCATTTTTCAGGGATAAATGCTAAGATAAAATTGCTTTTCCAGGTCATTTTTTTTTGTGGTAAGAATAAC
TAATGGAAAATAATGAAACACCCTGGGGTTTGGGGGTGCTAACAACTTGTGGCTTTAACTGACAGGAGCAATTAAAAAGAGCAAGAGGGT
TCTGCATTGGCATAGCTTAGGGAAGGGTTAATGATGTCGCCACAGGTCAGCTCCTGATCCTTGCCGACTTGATGTTGCTGTACCAGGGCT
TCCTCCCCAGAGGTGCAGCTTGCGTTTTGAGGGTGATTGCTACATATGTTGTTGCTAAACAGCTCAGTAACACACTTGAATGAATTTGGA
TACCAGATTGTCCTCATTACAGTTCTTTTACTCTTAGGGCACTCTACACTGGGGGTTGGGGTTGGGAGTGGTTAGTACATTTATTACATT
TATTAAGAAACGTAATGACATAAAAGGTTAGCTCTGGGCCAGACTTCTCTTACTCTGTGGGTAATGGCAAGGATGTGTAGGTAAACTTGG
TTCTTTTTTTTCCCTAAGATGACAGCTTGATTTTATCATCTGCAGTCAAATAACTGAGCCAATCCAAATTTAAATGATAGATGCTTTAAT
TGAGTTTAAGTAGCTGAAACTGCTGAGACACTAAACTTTAACCTTCTGATGACTTTTTAAAATGCCTCAAATGTGCACATGTATATAGGA
TATTTTTATAACTTCCCTGATGAATAATCTGATATTAAAGTAGTATTTGGACCCAGAGCCAGAACTCGGTGGTGGAGGCTGCTGGTCTCT
CCTCACCACCTTCTTTTGCACTTGGAAAGAACAGCAACATCTGGATAGAGTTCTAGCTTTGACTTCTCATTTCCTTGTCTTTTTGGGTGC
ATTCCTCAGCACACTTTTTTTTTAAACCTTTTTGTTTTGTTTTGTTTGTATTTCATGTGGTTTTATTTGGGGGTTTTGGTTTTTTCACCC
TTTTTTGTGATTTGCAATGATGTGCTTGCCCAGCTAACTTTTGAATTGCACTTTTTAATAAATATTCTTAACAATTTTTGAAGAAGGATA
TTTTATCTCATTTGAGATCATGGTAGGTTAAGAAAATATGCCTGTTGATGAAAGCTAAAAGCAAATTTATGAAACTAAAAGGGTGATTGA
CATCCATGTTTACACTCCGCTCTAATGTTTGATATATAAATAAGTTATTTTCAAATTAGGAAAAAACAGTGAGTATTACAAAGGGCTTCA
GATGTTTAGAGTACTAGGTTATTTATGTTTTACAAAGTTTGAATCTTCTATAAACTAAGAAAGGGGATGATCCTTAGATTTGCATTAAAA
TATAGAAGTCTTTTAAAGTAAATGTGAACCTTGTCTAAGTACTGTAATCCACACAACACATTATAAGAAGCAAACCAGCATCTTAAGGAA
TTATAAAATTACCCTATTTAAAAGCCATGCTATTGTTCTGCTATTACCAGATTTATTGTGCCACACAAAAGGATCATGTGTGTCAGCAGG
GGCCGTTTGGAACAAACCTAGTCATTAATGAGTAAGATACTCCTGTTAGTTCAGGGACCAAGTTTTATGACCCAGAGGCTTAATGATGTT
TGGATATATTTCAAATCGGCGTGCTTACCTCACTGATTTAAATTATTTTCTAAATAGTGGCCATTGTAGACCTGACTCAGGCTGAAGCTA
AATAGAGAACAATTTAGAAAGTTAACTAACAATACAGTGCATTCTACCCGTAGGGCCACCATGCCCTTCTGCCCCTGGCTGATTTGATCC
TGTGTCTGATCCCATTGCACCCTGACTGGGCAGTCCCTACAGAACCAGTGTTAATTTGAAGGGCCTCCACTCAGGCTCCAAATGTGGCAG
CCAAAGAGAACAATCCAGGGAACCTACATTTATTTTTAAGGACAAATATTTCCTCCTCAGTGGTCCTAATGTTCAGGGCTTTAGAGGGAA
CCCAGGTGGTCTCTTCACCCTGTGTCCTAGAATGGGAGAGTAAGTAGACAGTGGTGATAACCCCACACTGCTTATAAGTGCATCTTTATA
GTATTTGGGGCTTTCCTACCCCTTTAGCCTTCTGTACCTAGTACCATATTCCAGTTTTAAAGAACTGGCAGAATGTGATGGATAACAGAG
GAAGAGCTCAATTTATGTTTATTGGAAGAACATTTTACTTAAATGATTTGAGGGGTGGGAGGGAGTGAACTACTGAGTTTGCCAGAGTGA
AAATCCATCTGAAAAACTCAGCTACCTTTAGTTTTTAGTCCTCATTTTTGGTCTTGTCTCTGCGGACTGTGAAGAATCACAATGCTCTAT
ATGCCCTGGACTGTGTGGCAAATGCAGGTTGCAGCGTGTGTGTTACATGAGGATCTTCCACAATTTCAGAATGCACGCCAGAGCTGAAGG
GGGAAACTTGGTAACTTGCCCATTATTCTCTGCTTTTAGCCAGAGTTAAACAGACTGATGGGTCTGGTAGCCAACAACTTGGCAACTTCC
ACTCCTTCTCACCTCGTGAGATTAAGGGCTGTGAAAAGAAATCTAGTCTAACTCCAACAGAAATCTGTCTCTGTTAAGTGTTTTACCTTC
TGTAAGTAGAGATGGTAGAGCCAAGATTTTTCTTTTGGTAATTTCCCTGTCTATAAAGTGAGACCAAAGGGATATCTGTTCCCTGTTACC
TTTTTGGAGAATTCATAACATTTGAAGATCAAAAAATTGAATGATAAATATGAATGGCTTTTCAATTCTGTGGACTTTGTACCATTTGGC
TTCACCTTGTACTGCAAGATGAATTTGTAAACAAAACAAAATTGGACTGTCTGGAAAGCTAAAGTTCTGAAATATGGAATGTACTGCCTC
TAATTTTTCTTTGTCTTCCTCTCACTGGCATTTTTTTCTCTCCCAGGTTTCTTAAGAATAATGTTTTTTAAAGGAGGCTTTTTGCCCATC
AAGAATAAAAAGAAATAAAACCAAAGGGTTACCGGACTTAAGCCCCCGCAGTCACTGTGCGCCATCCCTGAGCAAAGTCCGCCCCTGAGG
ACAGTGCCCCTGCCCCAGTGACAGGCCTTACTCCTCCCAGGGCCTTTGCTTCTAATAGGGGGTGGTCTTTCTTTTCTTTCTCTCCTTTTT
TTTTTTTTGATTAAAAAATAAAACCAAACCAGAATTTGCTGAAAGCAGGTACCTTTCAGTAGCTCCGATCAGAGTAACTCAGCTTAGAGA

>In-frame_ENST00000367942_ENST00000258301_TCGA-LN-A49M_ATF6_chr1_161772062_+_STX6_chr1_180962561_length(amino acids)=477AA_start in transcript=10_stop in transcript=1443
MPPPSQILITEFQGEGTCEMGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWES
DIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKT
ENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPS
AQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNVGSDDMKDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTD
KYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATF6-STX6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ATF6	chr1:161772062	chr1:180962561	ENST00000367942	+	7	16	468_589	303.0	671.0	THBS4

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATF6-STX6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATF6-STX6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ATF6	C0152200	Achromatopsia	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	ATF6	C4225297	ACHROMATOPSIA 7	2	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	ATF6	C0003949	Asbestosis	1	CTD_human
Hgene	ATF6	C0009398	Color vision defect	1	CTD_human
Hgene	ATF6	C0022336	Creutzfeldt-Jakob disease	1	CTD_human
Hgene	ATF6	C0035334	Retinitis Pigmentosa	1	CTD_human
Hgene	ATF6	C0036457	Scrapie	1	CTD_human
Hgene	ATF6	C0085636	Photophobia	1	CTD_human
Hgene	ATF6	C0155015	Color Blindness, Red	1	CTD_human
Hgene	ATF6	C0155016	Color Blindness, Red-Green	1	CTD_human
Hgene	ATF6	C0155017	Color Blindness, Blue	1	CTD_human
Hgene	ATF6	C0155018	Color Blindness, Acquired	1	CTD_human
Hgene	ATF6	C0239777	Color Blindness, Green	1	CTD_human
Hgene	ATF6	C0242225	Color blindness	1	CTD_human
Hgene	ATF6	C0376329	New Variant Creutzfeldt-Jakob Disease	1	CTD_human
Hgene	ATF6	C0700501	Congenital nystagmus	1	CTD_human
Hgene	ATF6	C0751042	Color Blindness, Inherited	1	CTD_human
Hgene	ATF6	C0751043	Monochromatopsia	1	CTD_human
Hgene	ATF6	C0751254	Creutzfeldt-Jakob Disease, Familial	1	CTD_human
Hgene	ATF6	C2930617	Pulmonary Fibrosis - from Asbestos Exposure	1	CTD_human
Hgene	ATF6	C3489532	Cone-Rod Dystrophy 2	1	ORPHANET
Tgene	STX6	C0038868	Progressive supranuclear palsy	1	CTD_human
Tgene	STX6	C1866282	CEROID LIPOFUSCINOSIS, NEURONAL, 6	1	CTD_human
Tgene	STX6	C4551862	Ophthalmoplegia, Progressive Supranuclear	1	CTD_human
Tgene	STX6	C4551863	Supranuclear Palsy, Progressive, 1	1	CTD_human