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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF6-TENM3 (FusionGDB2 ID:7536)

Fusion Gene Summary for ATF6-TENM3

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF6-TENM3
Fusion gene ID: 7536
HgeneTgene
Gene symbol

ATF6

TENM3

Gene ID

22926

55714

Gene nameactivating transcription factor 6teneurin transmembrane protein 3
SynonymsACHM7|ATF6AMCOPCB9|MCOPS15|ODZ3|TEN3|TNM3|Ten-m3|ten-3
Cytomap

1q23.3

4q34.3-q35.1

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-6 alphacAMP-dependent transcription factor ATF-6 alphateneurin-3ODZ3-like proteinodz, odd Oz/ten-m homolog 3protein Odd Oz/ten-m homolog 3tenascin-M3testicular tissue protein Li 195
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367942, ENST00000476437, 
ENST00000511685, ENST00000406950, 
ENST00000502950, 
Fusion gene scores* DoF score12 X 10 X 8=96012 X 12 X 2=288
# samples 1213
** MAII scorelog2(12/960*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/288*10)=-1.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF6 [Title/Abstract] AND TENM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF6(161762117)-TENM3(183522077), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF6

GO:0043065

positive regulation of apoptotic process

14752510

HgeneATF6

GO:0045944

positive regulation of transcription by RNA polymerase II

14973138

HgeneATF6

GO:1903893

positive regulation of ATF6-mediated unfolded protein response

9837962

HgeneATF6

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

11163209|11256944|16469704


check buttonFusion gene breakpoints across ATF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TENM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-VT-A80J-01AATF6chr1

161762117

+TENM3chr4

183522077

+


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Fusion Gene ORF analysis for ATF6-TENM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367942ENST00000511685ATF6chr1

161762117

+TENM3chr4

183522077

+
In-frameENST00000367942ENST00000406950ATF6chr1

161762117

+TENM3chr4

183522077

+
5CDS-intronENST00000367942ENST00000502950ATF6chr1

161762117

+TENM3chr4

183522077

+
intron-3CDSENST00000476437ENST00000511685ATF6chr1

161762117

+TENM3chr4

183522077

+
intron-3CDSENST00000476437ENST00000406950ATF6chr1

161762117

+TENM3chr4

183522077

+
intron-intronENST00000476437ENST00000502950ATF6chr1

161762117

+TENM3chr4

183522077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367942ATF6chr1161762117+ENST00000511685TENM3chr4183522077+110177551083432777
ENST00000367942ATF6chr1161762117+ENST00000406950TENM3chr4183522077+86727551083432777

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367942ENST00000511685ATF6chr1161762117+TENM3chr4183522077+0.0001789220.9998211
ENST00000367942ENST00000406950ATF6chr1161762117+TENM3chr4183522077+0.0004202070.99957985

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Fusion Genomic Features for ATF6-TENM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATF6chr1161762117+TENM3chr4183522076+0.0001580020.9998419
ATF6chr1161762117+TENM3chr4183522076+0.0001580020.9998419

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATF6-TENM3


check button Go to

FGviewer for the breakpoints of chr1:161762117-chr4:183522077

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616124_127229.33333333333334671.0Compositional biasNote=Poly-Ser
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+6161_150229.33333333333334671.0RegionTranscription activation
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127514_545170.333333333333342700.0DomainEGF-like 1
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127546_576170.333333333333342700.0DomainEGF-like 2
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127578_610170.333333333333342700.0DomainEGF-like 3
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127611_642170.333333333333342700.0DomainEGF-like 4
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127644_677170.333333333333342700.0DomainEGF-like 5
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127678_709170.333333333333342700.0DomainEGF-like 6
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127710_739170.333333333333342700.0DomainEGF-like 7
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127740_774170.333333333333342700.0DomainEGF-like 8
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228514_545170.333333333333342700.0DomainEGF-like 1
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228546_576170.333333333333342700.0DomainEGF-like 2
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228578_610170.333333333333342700.0DomainEGF-like 3
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228611_642170.333333333333342700.0DomainEGF-like 4
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228644_677170.333333333333342700.0DomainEGF-like 5
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228678_709170.333333333333342700.0DomainEGF-like 6
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228710_739170.333333333333342700.0DomainEGF-like 7
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228740_774170.333333333333342700.0DomainEGF-like 8
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271200_1244170.333333333333342700.0RepeatNote=NHL 1
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271270_1314170.333333333333342700.0RepeatNote=NHL 2
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271331_1371170.333333333333342700.0RepeatNote=NHL 3
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271402_1429170.333333333333342700.0RepeatNote=NHL 4
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271458_1501170.333333333333342700.0RepeatNote=NHL 5
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271511_1530170.333333333333342700.0RepeatNote=YD 1
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271547_1567170.333333333333342700.0RepeatNote=YD 2
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271610_1629170.333333333333342700.0RepeatNote=YD 3
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271630_1652170.333333333333342700.0RepeatNote=YD 4
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271823_1842170.333333333333342700.0RepeatNote=YD 5
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271864_1882170.333333333333342700.0RepeatNote=YD 6
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271883_1903170.333333333333342700.0RepeatNote=YD 7
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271910_1927170.333333333333342700.0RepeatNote=YD 8
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271928_1949170.333333333333342700.0RepeatNote=YD 9
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271950_1967170.333333333333342700.0RepeatNote=YD 10
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271970_1990170.333333333333342700.0RepeatNote=YD 11
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271993_2013170.333333333333342700.0RepeatNote=YD 12
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272021_2040170.333333333333342700.0RepeatNote=YD 13
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272046_2063170.333333333333342700.0RepeatNote=YD 14
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272064_2090170.333333333333342700.0RepeatNote=YD 15
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272092_2105170.333333333333342700.0RepeatNote=YD 16
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272106_2129170.333333333333342700.0RepeatNote=YD 17
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272132_2152170.333333333333342700.0RepeatNote=YD 18
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272153_2173170.333333333333342700.0RepeatNote=YD 19
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272175_2195170.333333333333342700.0RepeatNote=YD 20
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272207_2227170.333333333333342700.0RepeatNote=YD 21
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272229_2249170.333333333333342700.0RepeatNote=YD 22
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501272275_2316170.333333333333342700.0RepeatNote=YD 23
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281200_1244170.333333333333342700.0RepeatNote=NHL 1
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281270_1314170.333333333333342700.0RepeatNote=NHL 2
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281331_1371170.333333333333342700.0RepeatNote=NHL 3
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281402_1429170.333333333333342700.0RepeatNote=NHL 4
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281458_1501170.333333333333342700.0RepeatNote=NHL 5
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281511_1530170.333333333333342700.0RepeatNote=YD 1
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281547_1567170.333333333333342700.0RepeatNote=YD 2
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281610_1629170.333333333333342700.0RepeatNote=YD 3
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281630_1652170.333333333333342700.0RepeatNote=YD 4
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281823_1842170.333333333333342700.0RepeatNote=YD 5
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281864_1882170.333333333333342700.0RepeatNote=YD 6
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281883_1903170.333333333333342700.0RepeatNote=YD 7
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281910_1927170.333333333333342700.0RepeatNote=YD 8
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281928_1949170.333333333333342700.0RepeatNote=YD 9
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281950_1967170.333333333333342700.0RepeatNote=YD 10
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281970_1990170.333333333333342700.0RepeatNote=YD 11
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281993_2013170.333333333333342700.0RepeatNote=YD 12
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282021_2040170.333333333333342700.0RepeatNote=YD 13
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282046_2063170.333333333333342700.0RepeatNote=YD 14
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282064_2090170.333333333333342700.0RepeatNote=YD 15
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282092_2105170.333333333333342700.0RepeatNote=YD 16
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282106_2129170.333333333333342700.0RepeatNote=YD 17
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282132_2152170.333333333333342700.0RepeatNote=YD 18
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282153_2173170.333333333333342700.0RepeatNote=YD 19
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282175_2195170.333333333333342700.0RepeatNote=YD 20
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282207_2227170.333333333333342700.0RepeatNote=YD 21
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282229_2249170.333333333333342700.0RepeatNote=YD 22
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852282275_2316170.333333333333342700.0RepeatNote=YD 23
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127332_2699170.333333333333342700.0Topological domainExtracellular
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228332_2699170.333333333333342700.0Topological domainExtracellular
TgeneTENM3chr1:161762117chr4:183522077ENST00000406950127311_331170.333333333333342700.0TransmembraneHelical
TgeneTENM3chr1:161762117chr4:183522077ENST00000511685228311_331170.333333333333342700.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616325_328229.33333333333334671.0Compositional biasNote=Poly-Lys
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616463_466229.33333333333334671.0Compositional biasNote=Poly-Pro
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616306_369229.33333333333334671.0DomainbZIP
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616308_339229.33333333333334671.0RegionNote=Basic motif
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616348_355229.33333333333334671.0RegionNote=Leucine-zipper
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+6161_377229.33333333333334671.0Topological domainCytoplasmic
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616399_670229.33333333333334671.0Topological domainLumenal
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616378_398229.33333333333334671.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271_309170.333333333333342700.0DomainTeneurin N-terminal
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281_309170.333333333333342700.0DomainTeneurin N-terminal
TgeneTENM3chr1:161762117chr4:183522077ENST000004069501271_310170.333333333333342700.0Topological domainCytoplasmic
TgeneTENM3chr1:161762117chr4:183522077ENST000005116852281_310170.333333333333342700.0Topological domainCytoplasmic


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Fusion Gene Sequence for ATF6-TENM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000367942_ENST00000511685_TCGA-VT-A80J-01A_ATF6_chr1_161762117_+_TENM3_chr4_183522077_length(transcript)=11017nt_BP=755nt
TTTTGTCCGCCTGCCGCCGCCGTCCCAGATATTAATCACGGAGTTCCAGGGAGAAGGAACTTGTGAAATGGGGGAGCCGGCTGGGGTTGC
CGGCACCATGGAGTCACCTTTTAGCCCGGGACTCTTTCACAGGCTGGATGAAGATTGGGATTCTGCTCTCTTTGCTGAACTCGGTTATTT
CACAGACACTGATGAGCTGCAATTGGAAGCAGCAAATGAGACGTATGAAAACAATTTTGATAATCTTGATTTTGATTTGGATTTGATGCC
TTGGGAGTCAGACATTTGGGACATCAACAACCAAATCTGTACAGTTAAAGATATTAAGGCAGAACCTCAGCCACTTTCTCCAGCCTCCTC
AAGTTATTCAGTCTCGTCTCCTCGGTCAGTGGACTCTTATTCTTCAACTCAGCATGTTCCTGAGGAGTTGGATTTGTCTTCTAGTTCTCA
GATGTCTCCCCTTTCCTTATATGGTGAAAACTCTAATAGTCTCTCTTCAGCGGAGCCACTGAAGGAAGATAAGCCTGTCACTGGTCCTAG
GAACAAGACTGAAAATGGACTGACTCCAAAGAAAAAAATTCAGGTGAATTCAAAACCTTCAATTCAGCCCAAGCCTTTATTGCTTCCAGC
AGCACCCAAGACTCAAACAAACTCCAGTGTTCCAGCAAAAACCATCATTATTCAGACAGTACCAACGCTTATGCCATTGGCAAAGCAGCA
ACCAATTATCAGTTTACAACCTGCACCCACTAAAGAGCAACCTGCAAGCAATCAAGGCCAGTCTACCCTGCAGCCCTTGCCGCCTTCCCA
TAAGCAGCACTCTGCACAGCATCATCCATCCATCACTTCTCTCAACAGAAACTCCCTGACCAATAGAAGGAACCAGAGTCCGGCCCCGCC
GGCTGCTTTGCCCGCCGAGCTGCAAACCACACCCGAGTCCGTCCAGCTGCAGGACAGCTGGGTCCTTGGCAGTAATGTACCACTGGAAAG
CAGGCATTTCCTATTCAAAACAGGAACAGGTACAACGCCACTGTTCAGTACTGCAACCCCAGGATACACAATGGCATCTGGCTCTGTTTA
TTCACCACCTACTCGGCCACTACCTAGAAACACCCTATCAAGAAGTGCTTTTAAATTCAAGAAGTCTTCAAAGTACTGTAGCTGGAAATG
CACTGCACTGTGTGCCGTAGGGGTCTCGGTGCTCCTGGCAATACTCCTGTCTTATTTTATAGCAATGCATCTCTTTGGCCTCAACTGGCA
GCTACAGCAGACTGAAAATGACACATTTGAGAATGGAAAAGTGAATTCTGATACCATGCCAACAAACACTGTGTCATTACCTTCTGGAGA
CAATGGAAAATTAGGTGGATTTACGCAAGAAAATAACACCATAGATTCCGGAGAACTTGATATTGGCCGAAGAGCAATTCAAGAGATTCC
TCCCGGGATCTTCTGGAGATCACAGCTCTTCATTGATCAGCCACAGTTTCTTAAATTCAATATCTCTCTTCAGAAGGATGCATTGATTGG
AGTATATGGCCGGAAAGGCTTACCGCCTTCCCATACTCAGTATGACTTCGTGGAGCTCCTGGATGGCAGCAGGCTGATTGCCAGAGAGCA
GCGGAGCCTGCTTGAGACGGAGAGAGCCGGGCGGCAGGCGAGATCCGTCAGCCTTCATGAGGCCGGCTTTATCCAGTACTTGGATTCTGG
AATCTGGCATCTGGCTTTTTATAATGATGGGAAAAATGCAGAGCAGGTGTCTTTTAATACCATTGTTATAGAGTCTGTGGTGGAATGTCC
CCGAAATTGCCATGGAAATGGAGAATGCGTTTCTGGAACTTGCCATTGTTTTCCAGGATTTCTGGGTCCGGATTGTTCAAGAGCCGCCTG
TCCAGTGTTATGTAGTGGCAACGGGCAGTACTCCAAGGGCCGCTGCCTGTGTTTCAGCGGCTGGAAGGGCACCGAGTGTGATGTGCCGAC
TACCCAGTGTATTGACCCACAGTGTGGGGGTCGTGGGATTTGTATCATGGGCTCTTGTGCTTGCAACTCAGGATACAAAGGAGAAAGTTG
TGAAGAAGCTGACTGTATAGACCCTGGGTGTTCTAATCATGGTGTGTGTATCCACGGGGAATGTCACTGCAGTCCAGGATGGGGAGGTAG
CAATTGTGAAATACTGAAGACCATGTGTCCAGACCAGTGCTCCGGCCACGGAACGTATCTTCAAGAAAGTGGCTCCTGCACGTGTGACCC
TAACTGGACTGGCCCAGACTGCTCAAACGAAATATGTTCTGTGGACTGTGGCTCACACGGCGTTTGCATGGGGGGGACGTGTCGCTGTGA
AGAAGGCTGGACGGGCCCAGCCTGTAATCAGAGAGCCTGCCACCCCCGCTGTGCCGAGCACGGGACCTGCAAGGATGGCAAGTGTGAATG
CAGCCAGGGCTGGAATGGAGAGCACTGCACTATCGAGGGTTGTCCTGGTCTGTGCAACAGCAATGGAAGATGTACCCTGGACCAAAATGG
CTGGCATTGTGTGTGCCAGCCTGGATGGAGAGGAGCAGGCTGTGACGTAGCCATGGAGACTCTTTGCACAGATAGCAAGGACAATGAAGG
AGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCCAGAATCAGCCCTATTGTCGGGGACTGCCGGATCCTCA
GGACATCATTAGCCAAAGCCTTCAATCGCCTTCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAGGATCTGATAG
CACCCATGTTATACCTGGAGAAAGTCCTTTCAATAAGAGCCTTGCATCTGTCATCAGAGGCCAAGTACTGACTGCTGATGGAACTCCACT
TATTGGAGTAAATGTCTCGTTTTTCCATTACCCAGAATATGGATATACTATTACCCGCCAGGACGGAATGTTTGACTTGGTGGCAAATGG
TGGGGCCTCTCTAACTTTGGTATTTGAACGATCCCCATTCCTCACTCAGTATCATACTGTGTGGATTCCATGGAATGTCTTTTATGTGAT
GGATACCCTAGTCATGAAGAAAGAAGAGAATGATATTCCCAGCTGTGATCTGAGTGGATTCGTGAGGCCAAATCCCATCATTGTGTCATC
ACCTTTATCCACCTTTTTCAGATCTTCTCCTGAAGACAGTCCCATCATTCCCGAAACACAGGTACTCCACGAGGAAACTACAATTCCAGG
AACAGATTTGAAACTCTCCTACTTGAGTTCCAGAGCTGCAGGGTATAAGTCAGTTCTCAAGATCACCATGACCCAGTCTATTATTCCATT
TAATTTAATGAAGGTTCATCTTATGGTAGCTGTAGTAGGAAGACTCTTCCAAAAGTGGTTTCCTGCCTCACCAAACTTGGCCTATACTTT
CATATGGGATAAAACAGATGCATATAATCAGAAAGTCTATGGTCTATCTGAAGCTGTTGTGTCAGTTGGATATGAGTATGAGTCGTGTTT
GGACCTGACTCTGTGGGAAAAGAGGACTGCCATTCTGCAGGGCTATGAATTGGATGCGTCCAACATGGGTGGCTGGACATTAGATAAACA
TCACGTGCTGGATGTACAGAACGGTATACTGTACAAGGGAAACGGGGAAAACCAGTTCATCTCCCAGCAGCCTCCAGTCGTGAGTAGCAT
CATGGGCAATGGGCGAAGGCGCAGCATTTCCTGCCCCAGTTGCAATGGTCAAGCTGATGGTAACAAGTTACTGGCCCCAGTGGCGCTAGC
TTGTGGGATCGATGGCAGTCTGTACGTAGGCGATTTCAACTATGTGCGGCGGATATTCCCTTCTGGAAATGTAACAAGTGTCTTAGAACT
AAGCAGCAACCCAGCTCATAGATACTACCTTGCAACGGATCCAGTCACGGGAGATCTGTACGTTTCTGACACAAACACCCGCAGAATTTA
TCGCCCAAAGTCACTTACGGGGGCAAAAGACTTGACTAAAAATGCAGAAGTCGTCGCAGGGACAGGGGAGCAATGCCTTCCGTTTGACGA
GGCGAGATGTGGGGATGGAGGGAAGGCCGTGGAAGCCACACTCATGAGTCCCAAAGGAATGGCAGTTGATAAGAATGGATTAATCTACTT
TGTTGATGGAACCATGATTAGGAAAGTTGACCAAAATGGAATCATATCAACTCTTCTGGGCTCTAACGATTTGACTTCAGCCAGACCTTT
AACTTGTGACACCAGCATGCACATCAGCCAGGTACGTCTGGAATGGCCCACTGACCTAGCCATTAACCCTATGGATAACTCCATTTATGT
CCTGGATAATAATGTAGTTTTACAGATCACTGAAAATCGTCAAGTTCGCATTGCTGCTGGACGGCCCATGCACTGTCAGGTTCCCGGAGT
GGAATATCCTGTGGGGAAGCACGCGGTGCAGACAACACTGGAATCAGCCACTGCCATTGCTGTGTCCTACAGTGGGGTCCTGTACATTAC
TGAAACTGATGAGAAGAAAATTAACCGGATAAGGCAGGTCACAACAGATGGAGAAATCTCCTTAGTGGCCGGAATACCTTCAGAGTGTGA
CTGCAAAAATGATGCCAACTGTGACTGTTACCAGAGTGGAGATGGCTACGCCAAGGATGCCAAACTCAGTGCCCCATCCTCCCTGGCTGC
TTCTCCAGATGGTACACTGTATATTGCAGATCTAGGGAATATCCGGATCCGGGCTGTGTCAAAGAATAAGCCTTTACTTAACTCTATGAA
CTTCTATGAAGTTGCGTCTCCAACTGATCAAGAACTCTACATCTTTGACATCAATGGTACTCACCAATATACTGTAAGTTTAGTCACTGG
TGATTACCTTTACAATTTTAGCTACAGCAATGACAATGATATTACTGCTGTGACAGACAGCAATGGCAACACCCTTAGAATTAGACGGGA
CCCAAATCGCATGCCAGTTCGAGTGGTGTCTCCTGATAACCAAGTGATATGGTTGACAATAGGAACAAATGGATGTTTGAAAAGCATGAC
TGCTCAAGGACTGGAATTAGTTTTGTTTACTTACCATGGCAATAGTGGCCTTTTAGCCACTAAAAGTGATGAAACTGGATGGACAACGTT
TTTTGACTATGACAGTGAAGGTCGTCTGACAAATGTTACGTTTCCAACTGGAGTGGTCACAAACCTGCATGGGGACATGGACAAGGCTAT
CACAGTGGACATTGAGTCATCTAGCCGAGAAGAAGATGTCAGCATCACTTCAAATCTGTCCTCGATCGATTCTTTCTACACCATGGTTCA
AGATCAGTTAAGAAACAGCTACCAGATTGGTTATGACGGCTCCCTCAGAATTATCTACGCCAGTGGCCTGGACTCACACTACCAAACAGA
GCCGCACGTTCTGGCTGGCACCGCTAATCCGACGGTTGCCAAAAGAAACATGACTTTGCCTGGCGAGAACGGTCAAAACTTGGTGGAATG
GAGATTCCGAAAAGAGCAAGCCCAAGGGAAAGTCAATGTCTTTGGCCGCAAGCTCAGGGTTAATGGCAGAAACCTCCTTTCAGTTGACTT
TGATCGAACAACAAAGACAGAAAAGATCTATGACGACCACCGTAAATTTCTACTGAGGATCGCCTACGACACGTCTGGGCACCCGACTCT
CTGGCTGCCAAGCAGCAAGCTGATGGCCGTCAATGTCACCTATTCATCCACAGGTCAAATTGCCAGCATCCAGCGAGGCACCACTAGCGA
GAAAGTAGATTATGACGGACAGGGGAGGATCGTGTCTCGGGTCTTTGCTGATGGTAAAACATGGAGTTACACATATTTAGAAAAGTCCAT
GGTTCTTCTGCTTCATAGCCAGCGGCAGTACATCTTCGAATACGATATGTGGGACCGCCTGTCTGCCATCACCATGCCCAGTGTGGCTCG
CCACACCATGCAGACCATCCGATCCATTGGCTACTACCGCAACATATACAACCCCCCGGAAAGCAACGCCTCCATCATCACGGACTACAA
CGAGGAAGGGCTGCTTCTACAAACAGCTTTCTTGGGTACAAGTCGGAGGGTCTTATTCAAATACAGAAGGCAGACTAGGCTCTCAGAAAT
TTTATATGATAGCACAAGAGTCAGTTTTACCTATGATGAAACAGCAGGAGTCCTAAAGACAGTAAACCTCCAGAGTGATGGTTTTATTTG
CACCATTAGATACAGGCAAATTGGTCCCCTGATTGACAGGCAGATTTTCCGCTTTAGTGAAGATGGGATGGTAAATGCAAGATTTGACTA
TAGCTATGACAACAGCTTTCGAGTGACCAGCATGCAGGGTGTGATCAATGAAACGCCACTGCCTATTGATCTGTATCAGTTTGATGACAT
TTCTGGCAAAGTTGAGCAGTTTGGAAAGTTTGGAGTTATATATTATGATATTAACCAGATCATTTCTACAGCTGTAATGACCTATACGAA
GCACTTTGATGCTCATGGCCGTATCAAGGAGATTCAATATGAGATATTCAGGTCGCTCATGTACTGGATTACAATTCAGTATGATAACAT
GGGTCGGGTAACCAAGAGAGAGATTAAAATAGGGCCCTTTGCCAACACCACCAAATATGCTTATGAATATGATGTTGATGGACAGCTCCA
AACAGTTTACCTCAATGAAAAGATAATGTGGCGGTACAACTACGATCTGAATGGAAACCTCCATTTACTGAACCCAAGTAACAGTGCGCG
TCTGACACCCCTTCGCTATGACCTGCGAGACAGAATCACTCGACTGGGTGATGTTCAATATCGGTTGGATGAAGATGGTTTCCTACGTCA
AAGGGGCACGGAAATCTTTGAATATAGCTCCAAGGGGCTTCTAACTCGAGTTTACAGTAAAGGCAGTGGCTGGACAGTGATCTACCGTTA
TGACGGCCTGGGAAGGCGTGTTTCTAGCAAAACCAGTCTAGGACAGCACCTGCAGTTTTTTTATGCTGACTTAACTTATCCCACTAGGAT
TACTCATGTCTACAACCATTCGAGTTCAGAAATTACCTCCCTGTATTATGATCTCCAAGGACATCTTTTTGCCATGGAAATCAGCAGTGG
GGATGAATTCTATATTGCATCGGATAACACAGGGACACCACTGGCTGTGTTCAGTAGCAATGGGCTTATGCTGAAACAGATTCAGTACAC
TGCATATGGGGAAATCTATTTTGACTCTAATATTGACTTTCAACTGGTAATTGGATTTCATGGTGGCCTGTATGACCCACTCACCAAATT
AATCCACTTTGGAGAAAGAGATTATGACATTTTGGCAGGACGGTGGACAACACCTGACATAGAAATCTGGAAAAGAATTGGGAAGGACCC
AGCTCCTTTTAACTTGTACATGTTTAGGAATAACAACCCTGCAAGCAAAATCCATGACGTGAAAGATTACATCACAGATGTTAACAGCTG
GCTGGTGACATTTGGTTTCCATCTGCACAATGCTATTCCTGGATTCCCTGTTCCCAAATTTGATTTAACAGAACCTTCTTACGAACTTGT
GAAGAGTCAGCAGTGGGATGATATACCGCCCATCTTCGGAGTCCAGCAGCAAGTGGCGCGGCAGGCCAAGGCCTTCCTGTCGCTGGGGAA
GATGGCCGAGGTGCAGGTGAGCCGGCGCCGGGCCGGCGGCGCGCAGTCCTGGCTGTGGTTCGCCACGGTCAAGTCGCTGATCGGCAAGGG
CGTCATGCTGGCCGTCAGCCAGGGCCGCGTGCAGACCAACGTGCTCAACATCGCCAACGAGGACTGCATCAAGGTGGCGGCCGTGCTCAA
CAACGCCTTCTACCTGGAGAACCTGCACTTCACCATCGAGGGCAAGGACACGCACTACTTCATCAAGACCACCACGCCCGAGAGCGACCT
GGGCACGCTGCGGTTGACCAGCGGCCGCAAGGCGCTGGAGAACGGCATCAACGTGACGGTGTCGCAGTCCACCACGGTGGTGAACGGCAG
GACGCGCAGGTTCGCGGACGTGGAGATGCAGTTCGGCGCGCTGGCGCTGCACGTGCGCTACGGCATGACCCTGGACGAGGAGAAGGCGCG
CATCCTGGAGCAGGCGCGGCAGCGCGCGCTCGCCCGGGCCTGGGCGCGCGAGCAGCAGCGCGTGCGCGACGGCGAGGAGGGCGCGCGCCT
CTGGACGGAGGGCGAGAAGCGGCAGCTGCTGAGCGCCGGCAAGGTGCAGGGCTACGACGGGTACTACGTACTCTCGGTGGAGCAGTACCC
CGAGCTGGCCGACAGCGCCAACAACATCCAGTTCCTGCGGCAGAGCGAGATCGGCAGGAGGTAACGCCCGGGCCGCGCCCGCCGAGCCGC
TCACGCCCTGCCCACATTGTCCTGTGGCACAACCCGAGTGGGACTCTCCAACGCCCAAGAGCCTTCCTCCCGGGGGAATGAGACTGCTGT
TACGACCCACACCCACACCGCGAAAACAAGGACCGCTTTTTTCCGAATGACCTTAAAGGTGATCGGCTTTAACGAATATGTTTACATATG
CATAGCGCTGCACTCAGTCGGACTGAACGTAGCCAGAGGAAAAAAAAATCATCAAGGACAAAGGCCTCGACCTGTTGCGCTGGGCCGTCT
GTTCCTTCTAGGCACTGTATTTAACTAACTTTAAAAAAGAAAAAAAAATGTGTACAGTGTTTCCAAATAGTCCCGAATTGTCGACCTTTG
CTTACAAGAAGTAGTCTGTCTGCATAGGATGTGATAGCTATCTCTGTTCATTTTACAATGTGGGGCAAAGTTACTGTTTCTAGACAACCC
AACTGCTTTCCCTGTGCAGCTTTGTAGAAGGACATTGGCACAGTGACTTCTGCGGCGGGGATTTATTAATGGATTTTACAATGCTAACGT
GGTTTCCCTTCGGGGAAAAAACTGGCAACTAGAATCCTTGTCACTGATAAGCAAAGGAAATCCTGATTTTTTTGTAAATTATGTGAGACA
AGTTGTTTATGGATTTTTATATGAATTACAATTTACTGTACATCAAATCTTAGTCTCAGAGGAGTTAATTTATGTAAAGTGTTTAAAAAT
TTATACTTAAAAATAAAATGATAAAAACGTGAACTGTGTGATTTTTTTAAAAGGATTGCACCTTTTGTTATCTGTTATAGCTGTACAGTA
TGAATTATTATATTGTAGAGATATAACAACTTATGCCTATAATGTCCAGAAGTGTTAATATTTTTGTATTAGGTTGAAAAAATGTGCAAG
CTTCTATCACTAGATGGATAGGACCGTGCAATTCTAGGTGGGTGGCGAATCAGAGAGCTCCTTTCTCTTCCCTCTCTCACGCATCAGGCC
AGTGTCCTCAGCATTGTCAACTGAGAGGCACAGTAGACAACTAGGGCTGGTGGAATGTAAGGGAAGAAGATTGAAAAAACGGGAGGAAGG
GTTCTCTGGCCCTCTCTCAACCTTGCAAGTCAATGGGGAGTTGTTGATATAATTAACCCCGAGGTTTTTACTGTTACTGTTCCAAAGCTC
TGTCTCTTGATGGAGGAGAGACCACATCAGATGCTGGGGAAATAGGAGGAGGAAAGGTTCTGATGTAGTCGTGATCCTAAACACGTGTCT
TAAGATCTAGGAAAGACAGCAGAAACCGAGCAGTGGTGGGTGAGCCAGATGGAGCCGGTCAGGGTTACTCTAAGCCCACATGACCAAACC
ATCTTGGGGGGCTGGTTTGAATGACAGCCTCTGCTCTGTCTCGGGGAAGCCGGGGGTGGCAGATCCAGCTGGAAGTGAACTGACAGCCGC
GCCCTCCTGCACACATGCATGCACGCGTGTGGGAACGAGCCCAGCCGCCATCTGCACTTCCGTGTCGGCTCAGCTCTGACAAATCTCTTT
CCTGAGCACTAAATTCAGCCACGAAAATATTTTTAGAAGATATTTCTCAGTTCATCGAGCTATAGTACACACTGTTTTCCTCTATGTATA
ATGGTGATAAAATATAGCAAGTGAACATGTCGTAAATATAAAGGTTCAAGTGATGTATTGAAAATAATTTTCTAACTGCTTTGTATGTAT
CACATACTCTAAATTGCACAGTAGGCGTGTTTATTAAACAGATGATTGGCTGGGAAAGTTTCAAAATAGCTACTGAATTTACAGTATCAG
TGCTATTACTGTCTTTGTGTATTTGGTAGAGCATACCGAAGTAATTAATCTTCTAATGAATGCTGATGATATTTTATTAGAATGAAAGCA
CAGATTAGCATTAATATTTTTTATTCTGGAAATCCTTTGGCAAGTATTATGAAGCCCAAATTTAGAAAACTATGAGATTTCAAACCACAT
AAACATGATTCTGTTTTCCATTTTATTTTTTAACTGTTAGGTATTTGCAGTTCTGTTCCGTGGAACTTCTGCAGGCCTGTATTTAGCATG
CTGTAAGTACTTTTGGGTGAAATAGGCTCTGAGTCTAAATTCTCAGACATGTTTCTGATGTATTACCATGAAAAGCTTGTGCCACATGAC
AGAAGTGAGATCATAGTCTTAACCTCTTCTTGACGTGGACTGGTCTTCACTCGGGCACCGATAAATAACAGATTTGGAGTATCTCCTGGT
GCTTATTTTAGATGATGAAGTCAAATCAACCCAATTAGTGTCCTGTTAGTAGGTATAATGAGCCTATTTCTTTCTAAAAAGACTTGTGAT
CTGGACATGCTTTTACAAGAAATAGTGACCTTGGGGAATATGTAAACAAAAGACCTTTTTCTAAGAGTTGGGAGGGGGTGGGGGACTGTA
TAATGAAAAGAATTAGCTTACAAAAAAGAAATTGATATTCAAAGTATTTTAGGCAAAGCCAGTCAAAATGCTTTCATGATATTTTGAGAT
GTAAATTTTGTCTGATTTGTATTGTTCTTTTCATTTGCCTTCTTAACTTTATATGTGACCTGAATTTTCCATAACTTGATGACTATAGAT

>In-frame_ENST00000367942_ENST00000511685_TCGA-VT-A80J-01A_ATF6_chr1_161762117_+_TENM3_chr4_183522077_length(amino acids)=2777AA_start in transcript=10_stop in transcript=8343
MPPPSQILITEFQGEGTCEMGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWES
DIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKT
ENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKEQPASNQGQSTLQPLPPSHKQH
SAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPP
TRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPTNTVSLPSGDNGK
LGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSL
LETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVL
CSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCE
ILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQG
WNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDII
SQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGAS
LTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDL
KLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLT
LWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGI
DGSLYVGDFNYVRRIFPSGNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARC
GDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDN
NVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKN
DANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYL
YNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDY
DSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHV
LAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLP
SSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTM
QTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIR
YRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFD
AHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP
LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHV
YNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHF
GERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQ
QWDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVAAVLNNAF
YLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILE

--------------------------------------------------------------
>In-frame_ENST00000367942_ENST00000406950_TCGA-VT-A80J-01A_ATF6_chr1_161762117_+_TENM3_chr4_183522077_length(transcript)=8672nt_BP=755nt
TTTTGTCCGCCTGCCGCCGCCGTCCCAGATATTAATCACGGAGTTCCAGGGAGAAGGAACTTGTGAAATGGGGGAGCCGGCTGGGGTTGC
CGGCACCATGGAGTCACCTTTTAGCCCGGGACTCTTTCACAGGCTGGATGAAGATTGGGATTCTGCTCTCTTTGCTGAACTCGGTTATTT
CACAGACACTGATGAGCTGCAATTGGAAGCAGCAAATGAGACGTATGAAAACAATTTTGATAATCTTGATTTTGATTTGGATTTGATGCC
TTGGGAGTCAGACATTTGGGACATCAACAACCAAATCTGTACAGTTAAAGATATTAAGGCAGAACCTCAGCCACTTTCTCCAGCCTCCTC
AAGTTATTCAGTCTCGTCTCCTCGGTCAGTGGACTCTTATTCTTCAACTCAGCATGTTCCTGAGGAGTTGGATTTGTCTTCTAGTTCTCA
GATGTCTCCCCTTTCCTTATATGGTGAAAACTCTAATAGTCTCTCTTCAGCGGAGCCACTGAAGGAAGATAAGCCTGTCACTGGTCCTAG
GAACAAGACTGAAAATGGACTGACTCCAAAGAAAAAAATTCAGGTGAATTCAAAACCTTCAATTCAGCCCAAGCCTTTATTGCTTCCAGC
AGCACCCAAGACTCAAACAAACTCCAGTGTTCCAGCAAAAACCATCATTATTCAGACAGTACCAACGCTTATGCCATTGGCAAAGCAGCA
ACCAATTATCAGTTTACAACCTGCACCCACTAAAGAGCAACCTGCAAGCAATCAAGGCCAGTCTACCCTGCAGCCCTTGCCGCCTTCCCA
TAAGCAGCACTCTGCACAGCATCATCCATCCATCACTTCTCTCAACAGAAACTCCCTGACCAATAGAAGGAACCAGAGTCCGGCCCCGCC
GGCTGCTTTGCCCGCCGAGCTGCAAACCACACCCGAGTCCGTCCAGCTGCAGGACAGCTGGGTCCTTGGCAGTAATGTACCACTGGAAAG
CAGGCATTTCCTATTCAAAACAGGAACAGGTACAACGCCACTGTTCAGTACTGCAACCCCAGGATACACAATGGCATCTGGCTCTGTTTA
TTCACCACCTACTCGGCCACTACCTAGAAACACCCTATCAAGAAGTGCTTTTAAATTCAAGAAGTCTTCAAAGTACTGTAGCTGGAAATG
CACTGCACTGTGTGCCGTAGGGGTCTCGGTGCTCCTGGCAATACTCCTGTCTTATTTTATAGCAATGCATCTCTTTGGCCTCAACTGGCA
GCTACAGCAGACTGAAAATGACACATTTGAGAATGGAAAAGTGAATTCTGATACCATGCCAACAAACACTGTGTCATTACCTTCTGGAGA
CAATGGAAAATTAGGTGGATTTACGCAAGAAAATAACACCATAGATTCCGGAGAACTTGATATTGGCCGAAGAGCAATTCAAGAGATTCC
TCCCGGGATCTTCTGGAGATCACAGCTCTTCATTGATCAGCCACAGTTTCTTAAATTCAATATCTCTCTTCAGAAGGATGCATTGATTGG
AGTATATGGCCGGAAAGGCTTACCGCCTTCCCATACTCAGTATGACTTCGTGGAGCTCCTGGATGGCAGCAGGCTGATTGCCAGAGAGCA
GCGGAGCCTGCTTGAGACGGAGAGAGCCGGGCGGCAGGCGAGATCCGTCAGCCTTCATGAGGCCGGCTTTATCCAGTACTTGGATTCTGG
AATCTGGCATCTGGCTTTTTATAATGATGGGAAAAATGCAGAGCAGGTGTCTTTTAATACCATTGTTATAGAGTCTGTGGTGGAATGTCC
CCGAAATTGCCATGGAAATGGAGAATGCGTTTCTGGAACTTGCCATTGTTTTCCAGGATTTCTGGGTCCGGATTGTTCAAGAGCCGCCTG
TCCAGTGTTATGTAGTGGCAACGGGCAGTACTCCAAGGGCCGCTGCCTGTGTTTCAGCGGCTGGAAGGGCACCGAGTGTGATGTGCCGAC
TACCCAGTGTATTGACCCACAGTGTGGGGGTCGTGGGATTTGTATCATGGGCTCTTGTGCTTGCAACTCAGGATACAAAGGAGAAAGTTG
TGAAGAAGCTGACTGTATAGACCCTGGGTGTTCTAATCATGGTGTGTGTATCCACGGGGAATGTCACTGCAGTCCAGGATGGGGAGGTAG
CAATTGTGAAATACTGAAGACCATGTGTCCAGACCAGTGCTCCGGCCACGGAACGTATCTTCAAGAAAGTGGCTCCTGCACGTGTGACCC
TAACTGGACTGGCCCAGACTGCTCAAACGAAATATGTTCTGTGGACTGTGGCTCACACGGCGTTTGCATGGGGGGGACGTGTCGCTGTGA
AGAAGGCTGGACGGGCCCAGCCTGTAATCAGAGAGCCTGCCACCCCCGCTGTGCCGAGCACGGGACCTGCAAGGATGGCAAGTGTGAATG
CAGCCAGGGCTGGAATGGAGAGCACTGCACTATCGAGGGTTGTCCTGGTCTGTGCAACAGCAATGGAAGATGTACCCTGGACCAAAATGG
CTGGCATTGTGTGTGCCAGCCTGGATGGAGAGGAGCAGGCTGTGACGTAGCCATGGAGACTCTTTGCACAGATAGCAAGGACAATGAAGG
AGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCCAGAATCAGCCCTATTGTCGGGGACTGCCGGATCCTCA
GGACATCATTAGCCAAAGCCTTCAATCGCCTTCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAGGATCTGATAG
CACCCATGTTATACCTGGAGAAAGTCCTTTCAATAAGAGCCTTGCATCTGTCATCAGAGGCCAAGTACTGACTGCTGATGGAACTCCACT
TATTGGAGTAAATGTCTCGTTTTTCCATTACCCAGAATATGGATATACTATTACCCGCCAGGACGGAATGTTTGACTTGGTGGCAAATGG
TGGGGCCTCTCTAACTTTGGTATTTGAACGATCCCCATTCCTCACTCAGTATCATACTGTGTGGATTCCATGGAATGTCTTTTATGTGAT
GGATACCCTAGTCATGAAGAAAGAAGAGAATGATATTCCCAGCTGTGATCTGAGTGGATTCGTGAGGCCAAATCCCATCATTGTGTCATC
ACCTTTATCCACCTTTTTCAGATCTTCTCCTGAAGACAGTCCCATCATTCCCGAAACACAGGTACTCCACGAGGAAACTACAATTCCAGG
AACAGATTTGAAACTCTCCTACTTGAGTTCCAGAGCTGCAGGGTATAAGTCAGTTCTCAAGATCACCATGACCCAGTCTATTATTCCATT
TAATTTAATGAAGGTTCATCTTATGGTAGCTGTAGTAGGAAGACTCTTCCAAAAGTGGTTTCCTGCCTCACCAAACTTGGCCTATACTTT
CATATGGGATAAAACAGATGCATATAATCAGAAAGTCTATGGTCTATCTGAAGCTGTTGTGTCAGTTGGATATGAGTATGAGTCGTGTTT
GGACCTGACTCTGTGGGAAAAGAGGACTGCCATTCTGCAGGGCTATGAATTGGATGCGTCCAACATGGGTGGCTGGACATTAGATAAACA
TCACGTGCTGGATGTACAGAACGGTATACTGTACAAGGGAAACGGGGAAAACCAGTTCATCTCCCAGCAGCCTCCAGTCGTGAGTAGCAT
CATGGGCAATGGGCGAAGGCGCAGCATTTCCTGCCCCAGTTGCAATGGTCAAGCTGATGGTAACAAGTTACTGGCCCCAGTGGCGCTAGC
TTGTGGGATCGATGGCAGTCTGTACGTAGGCGATTTCAACTATGTGCGGCGGATATTCCCTTCTGGAAATGTAACAAGTGTCTTAGAACT
AAGCAGCAACCCAGCTCATAGATACTACCTTGCAACGGATCCAGTCACGGGAGATCTGTACGTTTCTGACACAAACACCCGCAGAATTTA
TCGCCCAAAGTCACTTACGGGGGCAAAAGACTTGACTAAAAATGCAGAAGTCGTCGCAGGGACAGGGGAGCAATGCCTTCCGTTTGACGA
GGCGAGATGTGGGGATGGAGGGAAGGCCGTGGAAGCCACACTCATGAGTCCCAAAGGAATGGCAGTTGATAAGAATGGATTAATCTACTT
TGTTGATGGAACCATGATTAGGAAAGTTGACCAAAATGGAATCATATCAACTCTTCTGGGCTCTAACGATTTGACTTCAGCCAGACCTTT
AACTTGTGACACCAGCATGCACATCAGCCAGGTACGTCTGGAATGGCCCACTGACCTAGCCATTAACCCTATGGATAACTCCATTTATGT
CCTGGATAATAATGTAGTTTTACAGATCACTGAAAATCGTCAAGTTCGCATTGCTGCTGGACGGCCCATGCACTGTCAGGTTCCCGGAGT
GGAATATCCTGTGGGGAAGCACGCGGTGCAGACAACACTGGAATCAGCCACTGCCATTGCTGTGTCCTACAGTGGGGTCCTGTACATTAC
TGAAACTGATGAGAAGAAAATTAACCGGATAAGGCAGGTCACAACAGATGGAGAAATCTCCTTAGTGGCCGGAATACCTTCAGAGTGTGA
CTGCAAAAATGATGCCAACTGTGACTGTTACCAGAGTGGAGATGGCTACGCCAAGGATGCCAAACTCAGTGCCCCATCCTCCCTGGCTGC
TTCTCCAGATGGTACACTGTATATTGCAGATCTAGGGAATATCCGGATCCGGGCTGTGTCAAAGAATAAGCCTTTACTTAACTCTATGAA
CTTCTATGAAGTTGCGTCTCCAACTGATCAAGAACTCTACATCTTTGACATCAATGGTACTCACCAATATACTGTAAGTTTAGTCACTGG
TGATTACCTTTACAATTTTAGCTACAGCAATGACAATGATATTACTGCTGTGACAGACAGCAATGGCAACACCCTTAGAATTAGACGGGA
CCCAAATCGCATGCCAGTTCGAGTGGTGTCTCCTGATAACCAAGTGATATGGTTGACAATAGGAACAAATGGATGTTTGAAAAGCATGAC
TGCTCAAGGACTGGAATTAGTTTTGTTTACTTACCATGGCAATAGTGGCCTTTTAGCCACTAAAAGTGATGAAACTGGATGGACAACGTT
TTTTGACTATGACAGTGAAGGTCGTCTGACAAATGTTACGTTTCCAACTGGAGTGGTCACAAACCTGCATGGGGACATGGACAAGGCTAT
CACAGTGGACATTGAGTCATCTAGCCGAGAAGAAGATGTCAGCATCACTTCAAATCTGTCCTCGATCGATTCTTTCTACACCATGGTTCA
AGATCAGTTAAGAAACAGCTACCAGATTGGTTATGACGGCTCCCTCAGAATTATCTACGCCAGTGGCCTGGACTCACACTACCAAACAGA
GCCGCACGTTCTGGCTGGCACCGCTAATCCGACGGTTGCCAAAAGAAACATGACTTTGCCTGGCGAGAACGGTCAAAACTTGGTGGAATG
GAGATTCCGAAAAGAGCAAGCCCAAGGGAAAGTCAATGTCTTTGGCCGCAAGCTCAGGGTTAATGGCAGAAACCTCCTTTCAGTTGACTT
TGATCGAACAACAAAGACAGAAAAGATCTATGACGACCACCGTAAATTTCTACTGAGGATCGCCTACGACACGTCTGGGCACCCGACTCT
CTGGCTGCCAAGCAGCAAGCTGATGGCCGTCAATGTCACCTATTCATCCACAGGTCAAATTGCCAGCATCCAGCGAGGCACCACTAGCGA
GAAAGTAGATTATGACGGACAGGGGAGGATCGTGTCTCGGGTCTTTGCTGATGGTAAAACATGGAGTTACACATATTTAGAAAAGTCCAT
GGTTCTTCTGCTTCATAGCCAGCGGCAGTACATCTTCGAATACGATATGTGGGACCGCCTGTCTGCCATCACCATGCCCAGTGTGGCTCG
CCACACCATGCAGACCATCCGATCCATTGGCTACTACCGCAACATATACAACCCCCCGGAAAGCAACGCCTCCATCATCACGGACTACAA
CGAGGAAGGGCTGCTTCTACAAACAGCTTTCTTGGGTACAAGTCGGAGGGTCTTATTCAAATACAGAAGGCAGACTAGGCTCTCAGAAAT
TTTATATGATAGCACAAGAGTCAGTTTTACCTATGATGAAACAGCAGGAGTCCTAAAGACAGTAAACCTCCAGAGTGATGGTTTTATTTG
CACCATTAGATACAGGCAAATTGGTCCCCTGATTGACAGGCAGATTTTCCGCTTTAGTGAAGATGGGATGGTAAATGCAAGATTTGACTA
TAGCTATGACAACAGCTTTCGAGTGACCAGCATGCAGGGTGTGATCAATGAAACGCCACTGCCTATTGATCTGTATCAGTTTGATGACAT
TTCTGGCAAAGTTGAGCAGTTTGGAAAGTTTGGAGTTATATATTATGATATTAACCAGATCATTTCTACAGCTGTAATGACCTATACGAA
GCACTTTGATGCTCATGGCCGTATCAAGGAGATTCAATATGAGATATTCAGGTCGCTCATGTACTGGATTACAATTCAGTATGATAACAT
GGGTCGGGTAACCAAGAGAGAGATTAAAATAGGGCCCTTTGCCAACACCACCAAATATGCTTATGAATATGATGTTGATGGACAGCTCCA
AACAGTTTACCTCAATGAAAAGATAATGTGGCGGTACAACTACGATCTGAATGGAAACCTCCATTTACTGAACCCAAGTAACAGTGCGCG
TCTGACACCCCTTCGCTATGACCTGCGAGACAGAATCACTCGACTGGGTGATGTTCAATATCGGTTGGATGAAGATGGTTTCCTACGTCA
AAGGGGCACGGAAATCTTTGAATATAGCTCCAAGGGGCTTCTAACTCGAGTTTACAGTAAAGGCAGTGGCTGGACAGTGATCTACCGTTA
TGACGGCCTGGGAAGGCGTGTTTCTAGCAAAACCAGTCTAGGACAGCACCTGCAGTTTTTTTATGCTGACTTAACTTATCCCACTAGGAT
TACTCATGTCTACAACCATTCGAGTTCAGAAATTACCTCCCTGTATTATGATCTCCAAGGACATCTTTTTGCCATGGAAATCAGCAGTGG
GGATGAATTCTATATTGCATCGGATAACACAGGGACACCACTGGCTGTGTTCAGTAGCAATGGGCTTATGCTGAAACAGATTCAGTACAC
TGCATATGGGGAAATCTATTTTGACTCTAATATTGACTTTCAACTGGTAATTGGATTTCATGGTGGCCTGTATGACCCACTCACCAAATT
AATCCACTTTGGAGAAAGAGATTATGACATTTTGGCAGGACGGTGGACAACACCTGACATAGAAATCTGGAAAAGAATTGGGAAGGACCC
AGCTCCTTTTAACTTGTACATGTTTAGGAATAACAACCCTGCAAGCAAAATCCATGACGTGAAAGATTACATCACAGATGTTAACAGCTG
GCTGGTGACATTTGGTTTCCATCTGCACAATGCTATTCCTGGATTCCCTGTTCCCAAATTTGATTTAACAGAACCTTCTTACGAACTTGT
GAAGAGTCAGCAGTGGGATGATATACCGCCCATCTTCGGAGTCCAGCAGCAAGTGGCGCGGCAGGCCAAGGCCTTCCTGTCGCTGGGGAA
GATGGCCGAGGTGCAGGTGAGCCGGCGCCGGGCCGGCGGCGCGCAGTCCTGGCTGTGGTTCGCCACGGTCAAGTCGCTGATCGGCAAGGG
CGTCATGCTGGCCGTCAGCCAGGGCCGCGTGCAGACCAACGTGCTCAACATCGCCAACGAGGACTGCATCAAGGTGGCGGCCGTGCTCAA
CAACGCCTTCTACCTGGAGAACCTGCACTTCACCATCGAGGGCAAGGACACGCACTACTTCATCAAGACCACCACGCCCGAGAGCGACCT
GGGCACGCTGCGGTTGACCAGCGGCCGCAAGGCGCTGGAGAACGGCATCAACGTGACGGTGTCGCAGTCCACCACGGTGGTGAACGGCAG
GACGCGCAGGTTCGCGGACGTGGAGATGCAGTTCGGCGCGCTGGCGCTGCACGTGCGCTACGGCATGACCCTGGACGAGGAGAAGGCGCG
CATCCTGGAGCAGGCGCGGCAGCGCGCGCTCGCCCGGGCCTGGGCGCGCGAGCAGCAGCGCGTGCGCGACGGCGAGGAGGGCGCGCGCCT
CTGGACGGAGGGCGAGAAGCGGCAGCTGCTGAGCGCCGGCAAGGTGCAGGGCTACGACGGGTACTACGTACTCTCGGTGGAGCAGTACCC
CGAGCTGGCCGACAGCGCCAACAACATCCAGTTCCTGCGGCAGAGCGAGATCGGCAGGAGGTAACGCCCGGGCCGCGCCCGCCGAGCCGC
TCACGCCCTGCCCACATTGTCCTGTGGCACAACCCGAGTGGGACTCTCCAACGCCCAAGAGCCTTCCTCCCGGGGGAATGAGACTGCTGT
TACGACCCACACCCACACCGCGAAAACAAGGACCGCTTTTTTCCGAATGACCTTAAAGGTGATCGGCTTTAACGAATATGTTTACATATG
CATAGCGCTGCACTCAGTCGGACTGAACGTAGCCAGAGGAAAAAAAAATCATCAAGGACAAAGGCCTCGACCTGTTGCGCTGGGCCGTCT

>In-frame_ENST00000367942_ENST00000406950_TCGA-VT-A80J-01A_ATF6_chr1_161762117_+_TENM3_chr4_183522077_length(amino acids)=2777AA_start in transcript=10_stop in transcript=8343
MPPPSQILITEFQGEGTCEMGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWES
DIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKT
ENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKEQPASNQGQSTLQPLPPSHKQH
SAQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGSVYSPP
TRPLPRNTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLLAILLSYFIAMHLFGLNWQLQQTENDTFENGKVNSDTMPTNTVSLPSGDNGK
LGGFTQENNTIDSGELDIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDGSRLIAREQRSL
LETERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNAEQVSFNTIVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVL
CSGNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGESCEEADCIDPGCSNHGVCIHGECHCSPGWGGSNCE
ILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQG
WNGEHCTIEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDII
SQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFFHYPEYGYTITRQDGMFDLVANGGAS
LTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDL
KLSYLSSRAAGYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESCLDLT
LWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQFISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGI
DGSLYVGDFNYVRRIFPSGNVTSVLELSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARC
GDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDN
NVVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTTDGEISLVAGIPSECDCKN
DANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLVTGDYL
YNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDY
DSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHV
LAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLP
SSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTM
QTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIR
YRQIGPLIDRQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFD
AHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP
LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLTYPTRITHV
YNHSSSEITSLYYDLQGHLFAMEISSGDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKLIHF
GERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQ
QWDDIPPIFGVQQQVARQAKAFLSLGKMAEVQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIKVAAVLNNAF
YLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQSTTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILE

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Fusion Gene PPI Analysis for ATF6-TENM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATF6chr1:161762117chr4:183522077ENST00000367942+616468_589229.33333333333334671.0THBS4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF6-TENM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATF6-TENM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATF6C0152200Achromatopsia2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneATF6C4225297ACHROMATOPSIA 72CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneATF6C0003949Asbestosis1CTD_human
HgeneATF6C0009398Color vision defect1CTD_human
HgeneATF6C0022336Creutzfeldt-Jakob disease1CTD_human
HgeneATF6C0035334Retinitis Pigmentosa1CTD_human
HgeneATF6C0036457Scrapie1CTD_human
HgeneATF6C0085636Photophobia1CTD_human
HgeneATF6C0155015Color Blindness, Red1CTD_human
HgeneATF6C0155016Color Blindness, Red-Green1CTD_human
HgeneATF6C0155017Color Blindness, Blue1CTD_human
HgeneATF6C0155018Color Blindness, Acquired1CTD_human
HgeneATF6C0239777Color Blindness, Green1CTD_human
HgeneATF6C0242225Color blindness1CTD_human
HgeneATF6C0376329New Variant Creutzfeldt-Jakob Disease1CTD_human
HgeneATF6C0700501Congenital nystagmus1CTD_human
HgeneATF6C0751042Color Blindness, Inherited1CTD_human
HgeneATF6C0751043Monochromatopsia1CTD_human
HgeneATF6C0751254Creutzfeldt-Jakob Disease, Familial1CTD_human
HgeneATF6C2930617Pulmonary Fibrosis - from Asbestos Exposure1CTD_human
HgeneATF6C3489532Cone-Rod Dystrophy 21ORPHANET
TgeneTENM3C0009171Cocaine Abuse1CTD_human
TgeneTENM3C0236736Cocaine-Related Disorders1CTD_human
TgeneTENM3C0264423Asthma, Occupational1CTD_human
TgeneTENM3C0600427Cocaine Dependence1CTD_human
TgeneTENM3C2931501Microphthalmia associated with colobomatous cyst1ORPHANET
TgeneTENM3C3554592MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 91CTD_human;GENOMICS_ENGLAND