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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF6B-TMEM138 (FusionGDB2 ID:7544)

Fusion Gene Summary for ATF6B-TMEM138

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF6B-TMEM138
Fusion gene ID: 7544
HgeneTgene
Gene symbol

ATF6B

TMEM138

Gene ID

1388

51524

Gene nameactivating transcription factor 6 betatransmembrane protein 138
SynonymsCREB-RP|CREBL1|G13HSPC196
Cytomap

6p21.32

11q12.2

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-6 betaCreb-related proteincAMP response element-binding protein-related proteincAMP-dependent transcription factor ATF-6 betacAMP-responsive element-binding protein-like 1protein G13transmembrane protein 138
Modification date2020031320200313
UniProtAcc

Q99941

.
Ensembl transtripts involved in fusion geneENST00000375203, ENST00000375201, 
ENST00000468502, ENST00000549095, 
ENST00000427136, ENST00000439240, 
ENST00000475964, ENST00000547111, 
ENST00000293709, ENST00000383156, 
ENST00000467437, ENST00000553220, 
ENST00000425571, ENST00000435768, 
ENST00000476416, 		ENST00000278826, 
ENST00000542946, ENST00000540194, 
ENST00000381787, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 4 X 5=100
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATF6B [Title/Abstract] AND TMEM138 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF6B(32088547)-TMEM138(61136068), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF6B

GO:0045944

positive regulation of transcription by RNA polymerase II

14973138

HgeneATF6B

GO:1903892

negative regulation of ATF6-mediated unfolded protein response

9837962

HgeneATF6B

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

11256944


check buttonFusion gene breakpoints across ATF6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMEM138 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5728-11AATF6Bchr6

32088547

-TMEM138chr11

61136068

+


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Fusion Gene ORF analysis for ATF6B-TMEM138

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375203ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
5CDS-intronENST00000375203ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
5CDS-intronENST00000375203ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
5CDS-intronENST00000375203ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
In-frameENST00000375201ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
5CDS-intronENST00000375201ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
5CDS-intronENST00000375201ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
5CDS-intronENST00000375201ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000468502ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000468502ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000468502ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000468502ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000549095ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000549095ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000549095ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000549095ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000427136ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000427136ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000427136ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000427136ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000439240ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000439240ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000439240ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000439240ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000475964ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000475964ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000475964ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000475964ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000547111ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000547111ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000547111ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000547111ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000293709ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000293709ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000293709ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000293709ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000383156ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000383156ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000383156ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000383156ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000467437ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000467437ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000467437ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000467437ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000553220ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000553220ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000553220ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000553220ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000425571ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000425571ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000425571ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000425571ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000435768ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000435768ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000435768ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000435768ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-3CDSENST00000476416ENST00000278826ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000476416ENST00000542946ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000476416ENST00000540194ATF6Bchr6

32088547

-TMEM138chr11

61136068

+
intron-intronENST00000476416ENST00000381787ATF6Bchr6

32088547

-TMEM138chr11

61136068

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375203ATF6Bchr632088547-ENST00000278826TMEM138chr1161136068+17788659977322
ENST00000375201ATF6Bchr632088547-ENST00000278826TMEM138chr1161136068+178286922981319

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375203ENST00000278826ATF6Bchr632088547-TMEM138chr1161136068+0.0117540290.9882459
ENST00000375201ENST00000278826ATF6Bchr632088547-TMEM138chr1161136068+0.0099853660.9900147

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Fusion Genomic Features for ATF6B-TMEM138


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATF6Bchr632088547-TMEM138chr1161136068+0.57205290.4279471
ATF6Bchr632088547-TMEM138chr1161136068+0.57205290.4279471

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATF6B-TMEM138


check button Go to

FGviewer for the breakpoints of chr6:32088547-chr11:61136068

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF6B

Q99941

.
FUNCTION: [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-81896_105274.3333333333333701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-81896_105277.3333333333333704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-8182_86274.3333333333333701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-8182_86277.3333333333333704.0RegionNote=Transcription activation
TgeneTMEM138chr6:32088547chr11:61136068ENST0000054294603110_1300106.0TransmembraneHelical
TgeneTMEM138chr6:32088547chr11:61136068ENST000005429460341_610106.0TransmembraneHelical
TgeneTMEM138chr6:32088547chr11:61136068ENST00000542946037_270106.0TransmembraneHelical
TgeneTMEM138chr6:32088547chr11:61136068ENST000005429460380_1000106.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-11896_1050704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-11896_1050701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-11896_1050704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-11896_1050704.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-11896_1050701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-11896_1050701.0Compositional biasNote=Poly-Ser
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-118325_3880704.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-818325_388274.3333333333333701.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-818325_388277.3333333333333704.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-118325_3880701.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-118325_3880704.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-118325_3880704.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-118325_3880701.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-118325_3880701.0DomainbZIP
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-1182_860704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-118327_3470704.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-118350_3570704.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-818327_347274.3333333333333701.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-818350_357274.3333333333333701.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-818327_347277.3333333333333704.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-818350_357277.3333333333333704.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-1182_860701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-118327_3470701.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-118350_3570701.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-1182_860704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-118327_3470704.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-118350_3570704.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-1182_860704.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-118327_3470704.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-118350_3570704.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-1182_860701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-118327_3470701.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-118350_3570701.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-1182_860701.0RegionNote=Transcription activation
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-118327_3470701.0RegionBasic motif
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-118350_3570701.0RegionLeucine-zipper
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-1182_3960704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-118418_7030704.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-8182_396274.3333333333333701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-818418_703274.3333333333333701.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-8182_396277.3333333333333704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-818418_703277.3333333333333704.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-1182_3960701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-118418_7030701.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-1182_3960704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-118418_7030704.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-1182_3960704.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-118418_7030704.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-1182_3960701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-118418_7030701.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-1182_3960701.0Topological domainCytoplasmic
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-118418_7030701.0Topological domainLumenal
HgeneATF6Bchr6:32088547chr11:61136068ENST00000293709-118397_4170704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375201-818397_417274.3333333333333701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000375203-818397_417277.3333333333333704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000383156-118397_4170701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000425571-118397_4170704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000427136-118397_4170704.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000435768-118397_4170701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneATF6Bchr6:32088547chr11:61136068ENST00000439240-118397_4170701.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMEM138chr6:32088547chr11:61136068ENST0000027882635110_130125.33333333333333163.0TransmembraneHelical
TgeneTMEM138chr6:32088547chr11:61136068ENST000002788263541_61125.33333333333333163.0TransmembraneHelical
TgeneTMEM138chr6:32088547chr11:61136068ENST00000278826357_27125.33333333333333163.0TransmembraneHelical
TgeneTMEM138chr6:32088547chr11:61136068ENST000002788263580_100125.33333333333333163.0TransmembraneHelical


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Fusion Gene Sequence for ATF6B-TMEM138


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375203_ENST00000278826_TCGA-CG-5728-11A_ATF6B_chr6_32088547_-_TMEM138_chr11_61136068_length(transcript)=1778nt_BP=865nt
AACCGTCTCCTGGTTGGGGGGTGGGGGGGAAAGATGGCGGAGCTGATGCTGCTCAGCGAGATTGCTGACCCGACGCGTTTCTTCACCGAC
AACCTGCTTAGCCCGGAGGACTGGGGTCTGCAGAACAGCACCTTGTATTCTGGCCTAGATGAAGTGGCCGAGGAGCAGACGCAGCTCTTC
CGTTGCCCGGAGCAGGATGTCCCGTTTGACGGCAGCTCCCTGGACGTGGGGATGGATGTCAGCCCCTCTGAGCCCCCATGGGAACTCCTG
CCGATCTTCCCAGATCTTCAGGTGAAGTCTGAGCCATCTTCCCCCTGCTCTTCCTCCTCCCTCAGCTCCGAGTCATCGCGTCTCTCCACA
GAGCCATCCAGCGAGGCTCTTGGGGTAGGGGAGGTGCTCCATGTGAAGACAGAGTCCTTGGCACCCCCACTGTGTCTCCTGGGAGATGAC
CCAACATCCTCATTTGAAACCGTCCAGATCAACGTTATCCCCACCTCTGATGATTCCTCAGATGTCCAGACCAAGATAGAACCTGTCTCT
CCATGTTCTTCCGTCAACTCTGAGGCCTCCCTGCTCTCAGCCGACTCCTCCAGCCAGGCTTTTATAGGAGAGGAGGTCCTGGAAGTGAAG
ACAGAGTCCCTGTCCCCTTCAGGATGCCTCCTGTGGGATGTCCCAGCCCCCTCACTTGGAGCTGTCCAGATCAGCATGGGCCCATCCCTT
GATGGCTCCTCAGGCAAAGCCCTGCCCACCCGGAAGCCGCCACTGCAGCCCAAACCTGTAGTGCTAACCACTGTCCCAATGCCATCCAGA
GCTGTGCCTCCCAGCACCACAGTCCTTCTGCAGTCCCTCGTCCAGCCACCCCCAGCAGCAGTGTTGTACTGCTACTTCTATAAACGGACA
GCCGTAAGACTAGGCGATCCTCACTTCTACCAGGACTCTTTGTGGCTGCGCAAGGAGTTCATGCAAGTTCGAAGGTGACCTCTTGTCACA
CTGATGGATACTTTTCCTTCCTGATAGAAGCCACATTTGCTGCTTTGCAGGGAGAGTTGGCCCTATGCATGGGCAAACAGCTGGACTTTC
CAAGGAAGGTTCAGACTAGCTGTGTTCAGCATTCAAGAAGGAAGATCCTCCCTCTTGCACAATTAGAGTGTCCCCATCGGTCTCCAGTGC
GGCATCCCTTCCTTGCCTTCTACCTCTGTTCCACCCCCTTTCCTTCCTTTCCTCTCTGTACCATTCATTCTCCCTGACCGGCCTTTCTTG
CCGAGGGTTCTGTGGCTCTTACCCTTGTGAAGCTTTTCCTTTAGCCTGGGACAGAAGGACCTCCCAGCCCCCAAAGGATCTCCCAGTGAC
CAAAGGATGCGAAGAGTGATAGTTACGTGCTCCTGACTGATCACACCGCAGACATTTAGATTTTTATACCCAAGGCACTTTAAAAAAATG
TTTTATAAATAGAGAATAAATTGAATTCTTGTTCCATAAATGGGGGAGTCTGTCTGTCTAGCTAGATCTCTTCATGTTAAGAGGCGTGCC
AAGGTCCAGCTTAACATCTACTTGACCCAGAGGGAAGATGGAGCCACAGATGAAATACAGATCTTTGTTGAGATCCATTATGAGTACAAA
GTATTTTAGCAGAAATTCAAGATGGAATCTGATGCTGCATCCCCCACTCCTGGAGCTCCAGATGTGTGTGCTCTGTTCAGACTCTCTTTC

>In-frame_ENST00000375203_ENST00000278826_TCGA-CG-5728-11A_ATF6B_chr6_32088547_-_TMEM138_chr11_61136068_length(amino acids)=322AA_start in transcript=9_stop in transcript=977
MVGGWGGKMAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIF
PDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCS
SVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVP

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>In-frame_ENST00000375201_ENST00000278826_TCGA-CG-5728-11A_ATF6B_chr6_32088547_-_TMEM138_chr11_61136068_length(transcript)=1782nt_BP=869nt
GGCGGGCCTTGGGAACCGTCTCCTGGTTGGGGGGTGGGGGGGAAAGATGGCGGAGCTGATGCTGCTCAGCGAGATTGCTGACCCGACGCG
TTTCTTCACCGACAACCTGCTTAGCCCGGAGGACTGGGACAGCACCTTGTATTCTGGCCTAGATGAAGTGGCCGAGGAGCAGACGCAGCT
CTTCCGTTGCCCGGAGCAGGATGTCCCGTTTGACGGCAGCTCCCTGGACGTGGGGATGGATGTCAGCCCCTCTGAGCCCCCATGGGAACT
CCTGCCGATCTTCCCAGATCTTCAGGTGAAGTCTGAGCCATCTTCCCCCTGCTCTTCCTCCTCCCTCAGCTCCGAGTCATCGCGTCTCTC
CACAGAGCCATCCAGCGAGGCTCTTGGGGTAGGGGAGGTGCTCCATGTGAAGACAGAGTCCTTGGCACCCCCACTGTGTCTCCTGGGAGA
TGACCCAACATCCTCATTTGAAACCGTCCAGATCAACGTTATCCCCACCTCTGATGATTCCTCAGATGTCCAGACCAAGATAGAACCTGT
CTCTCCATGTTCTTCCGTCAACTCTGAGGCCTCCCTGCTCTCAGCCGACTCCTCCAGCCAGGCTTTTATAGGAGAGGAGGTCCTGGAAGT
GAAGACAGAGTCCCTGTCCCCTTCAGGATGCCTCCTGTGGGATGTCCCAGCCCCCTCACTTGGAGCTGTCCAGATCAGCATGGGCCCATC
CCTTGATGGCTCCTCAGGCAAAGCCCTGCCCACCCGGAAGCCGCCACTGCAGCCCAAACCTGTAGTGCTAACCACTGTCCCAATGCCATC
CAGAGCTGTGCCTCCCAGCACCACAGTCCTTCTGCAGTCCCTCGTCCAGCCACCCCCAGCAGCAGTGTTGTACTGCTACTTCTATAAACG
GACAGCCGTAAGACTAGGCGATCCTCACTTCTACCAGGACTCTTTGTGGCTGCGCAAGGAGTTCATGCAAGTTCGAAGGTGACCTCTTGT
CACACTGATGGATACTTTTCCTTCCTGATAGAAGCCACATTTGCTGCTTTGCAGGGAGAGTTGGCCCTATGCATGGGCAAACAGCTGGAC
TTTCCAAGGAAGGTTCAGACTAGCTGTGTTCAGCATTCAAGAAGGAAGATCCTCCCTCTTGCACAATTAGAGTGTCCCCATCGGTCTCCA
GTGCGGCATCCCTTCCTTGCCTTCTACCTCTGTTCCACCCCCTTTCCTTCCTTTCCTCTCTGTACCATTCATTCTCCCTGACCGGCCTTT
CTTGCCGAGGGTTCTGTGGCTCTTACCCTTGTGAAGCTTTTCCTTTAGCCTGGGACAGAAGGACCTCCCAGCCCCCAAAGGATCTCCCAG
TGACCAAAGGATGCGAAGAGTGATAGTTACGTGCTCCTGACTGATCACACCGCAGACATTTAGATTTTTATACCCAAGGCACTTTAAAAA
AATGTTTTATAAATAGAGAATAAATTGAATTCTTGTTCCATAAATGGGGGAGTCTGTCTGTCTAGCTAGATCTCTTCATGTTAAGAGGCG
TGCCAAGGTCCAGCTTAACATCTACTTGACCCAGAGGGAAGATGGAGCCACAGATGAAATACAGATCTTTGTTGAGATCCATTATGAGTA
CAAAGTATTTTAGCAGAAATTCAAGATGGAATCTGATGCTGCATCCCCCACTCCTGGAGCTCCAGATGTGTGTGCTCTGTTCAGACTCTC

>In-frame_ENST00000375201_ENST00000278826_TCGA-CG-5728-11A_ATF6B_chr6_32088547_-_TMEM138_chr11_61136068_length(amino acids)=319AA_start in transcript=22_stop in transcript=981
MVGGWGGKMAELMLLSEIADPTRFFTDNLLSPEDWDSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDL
QVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVN
SEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVPPST

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Fusion Gene PPI Analysis for ATF6B-TMEM138


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF6B-TMEM138


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF6B-TMEM138


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMEM138C0431399Familial aplasia of the vermis1GENOMICS_ENGLAND
TgeneTMEM138C1855675Arima syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneTMEM138C3280906JOUBERT SYNDROME 161GENOMICS_ENGLAND;UNIPROT