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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:RPL28-EPB41L1 (FusionGDB2 ID:75899) |
Fusion Gene Summary for RPL28-EPB41L1 |
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Fusion gene information | Fusion gene name: RPL28-EPB41L1 | Fusion gene ID: 75899 | Hgene | Tgene | Gene symbol | RPL28 | EPB41L1 | Gene ID | 6158 | 2036 |
Gene name | ribosomal protein L28 | erythrocyte membrane protein band 4.1 like 1 | |
Synonyms | L28 | 4.1N|MRD11 | |
Cytomap | 19q13.42 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | 60S ribosomal protein L28large ribosomal subunit protein eL28 | band 4.1-like protein 1neuron-type nonerythroid protein 4.1neuronal protein 4.1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q9H4G0 | |
Ensembl transtripts involved in fusion gene | ENST00000344063, ENST00000431533, ENST00000428193, ENST00000558815, ENST00000560583, ENST00000560055, ENST00000559463, ENST00000558131, ENST00000558752, ENST00000458349, | ENST00000202028, ENST00000373950, ENST00000441639, ENST00000373946, ENST00000338074, ENST00000373941, ENST00000479336, | |
Fusion gene scores | * DoF score | 22 X 17 X 5=1870 | 13 X 14 X 8=1456 |
# samples | 24 | 18 | |
** MAII score | log2(24/1870*10)=-2.96193195916648 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1456*10)=-3.01594154386902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPL28 [Title/Abstract] AND EPB41L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RPL28(55899611)-EPB41L1(34776411), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | AA776201 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
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Fusion Gene ORF analysis for RPL28-EPB41L1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000344063 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000344063 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000344063 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000344063 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000344063 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000344063 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000344063 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000431533 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000431533 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000431533 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000431533 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000431533 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000431533 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000431533 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000428193 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000428193 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000428193 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000428193 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000428193 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000428193 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000428193 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558815 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558815 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558815 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558815 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558815 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558815 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000558815 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-3CDS | ENST00000560583 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-3CDS | ENST00000560583 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-3CDS | ENST00000560583 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-3CDS | ENST00000560583 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-3CDS | ENST00000560583 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-3CDS | ENST00000560583 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
3UTR-intron | ENST00000560583 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000560055 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000560055 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000560055 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000560055 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000560055 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000560055 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000560055 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000559463 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000559463 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000559463 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000559463 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000559463 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000559463 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000559463 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558131 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558131 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558131 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558131 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558131 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558131 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000558131 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558752 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558752 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558752 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558752 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558752 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000558752 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000558752 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000458349 | ENST00000202028 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000458349 | ENST00000373950 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000458349 | ENST00000441639 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000458349 | ENST00000373946 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000458349 | ENST00000338074 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-3CDS | ENST00000458349 | ENST00000373941 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
intron-intron | ENST00000458349 | ENST00000479336 | RPL28 | chr19 | 55899611 | - | EPB41L1 | chr20 | 34776411 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for RPL28-EPB41L1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for RPL28-EPB41L1 |
![]() FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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Hgene | Tgene |
. | EPB41L1 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for RPL28-EPB41L1 |
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Fusion Gene PPI Analysis for RPL28-EPB41L1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RPL28-EPB41L1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RPL28-EPB41L1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPL28 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | EPB41L1 | C3280285 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 11 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | EPB41L1 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |