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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL8-ABCF1 (FusionGDB2 ID:76553)

Fusion Gene Summary for RPL8-ABCF1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL8-ABCF1
Fusion gene ID: 76553
HgeneTgene
Gene symbol

RPL8

ABCF1

Gene ID

6132

23

Gene nameribosomal protein L8ATP binding cassette subfamily F member 1
SynonymsL8ABC27|ABC50
Cytomap

8q24.3

6p21.33

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L8large ribosomal subunit protein uL2ATP-binding cassette sub-family F member 1ATP-binding cassette 50 (TNF-alpha stimulated)ATP-binding cassette, sub-family F (GCN20), member 1TNF-alpha-stimulated ABC proteinTNFalpha-inducible ATP-binding protein
Modification date2020032720200313
UniProtAcc.

Q8NE71

Ensembl transtripts involved in fusion geneENST00000529163, ENST00000394920, 
ENST00000527914, ENST00000262584, 
ENST00000528957, 		ENST00000326195, 
ENST00000376545, ENST00000396515, 
ENST00000457111, ENST00000452530, 
ENST00000416932, ENST00000470464, 
ENST00000419893, ENST00000448939, 
ENST00000457970, ENST00000475528, 
ENST00000457078, ENST00000412443, 
ENST00000546690, ENST00000421608, 
ENST00000486105, ENST00000383588, 
ENST00000383587, ENST00000400609, 
ENST00000485585, ENST00000426219, 
ENST00000421042, ENST00000552867, 
ENST00000454094, ENST00000494413, 
ENST00000423247, ENST00000420257, 
ENST00000456791, ENST00000495194, 
Fusion gene scores* DoF score36 X 18 X 15=97209 X 5 X 7=315
# samples 379
** MAII scorelog2(37/9720*10)=-4.71535913797683
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL8 [Title/Abstract] AND ABCF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL8(146015154)-ABCF1(30545853), # samples:1
Anticipated loss of major functional domain due to fusion event.RPL8-ABCF1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL8-ABCF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL8

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across RPL8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HI-7168-01ARPL8chr8

146015154

-ABCF1chr6

30545853

+


Top

Fusion Gene ORF analysis for RPL8-ABCF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000529163ENST00000326195RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000529163ENST00000376545RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000529163ENST00000396515RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000457111RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000452530RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000416932RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000470464RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000419893RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000448939RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000457970RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000475528RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000457078RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000412443RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000546690RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000421608RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000486105RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000383588RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000383587RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000400609RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000485585RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000426219RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000421042RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000552867RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000454094RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000494413RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000423247RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000420257RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000456791RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000529163ENST00000495194RPL8chr8

146015154

-ABCF1chr6

30545853

+
In-frameENST00000394920ENST00000326195RPL8chr8

146015154

-ABCF1chr6

30545853

+
In-frameENST00000394920ENST00000376545RPL8chr8

146015154

-ABCF1chr6

30545853

+
In-frameENST00000394920ENST00000396515RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000457111RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000452530RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000416932RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000470464RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000419893RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000448939RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000457970RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000475528RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000457078RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000412443RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000546690RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000421608RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000486105RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000383588RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000383587RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000400609RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000485585RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000426219RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000421042RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000552867RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000454094RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000494413RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000423247RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000420257RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000456791RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000394920ENST00000495194RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000527914ENST00000326195RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000527914ENST00000376545RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000527914ENST00000396515RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000457111RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000452530RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000416932RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000470464RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000419893RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000448939RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000457970RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000475528RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000457078RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000412443RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000546690RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000421608RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000486105RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000383588RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000383587RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000400609RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000485585RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000426219RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000421042RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000552867RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000454094RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000494413RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000423247RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000420257RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000456791RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000527914ENST00000495194RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000262584ENST00000326195RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000262584ENST00000376545RPL8chr8

146015154

-ABCF1chr6

30545853

+
Frame-shiftENST00000262584ENST00000396515RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000457111RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000452530RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000416932RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000470464RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000419893RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000448939RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000457970RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000475528RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000457078RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000412443RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000546690RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000421608RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000486105RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000383588RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000383587RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000400609RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000485585RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000426219RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000421042RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000552867RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000454094RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000494413RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000423247RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000420257RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000456791RPL8chr8

146015154

-ABCF1chr6

30545853

+
5CDS-intronENST00000262584ENST00000495194RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-3CDSENST00000528957ENST00000326195RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-3CDSENST00000528957ENST00000376545RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-3CDSENST00000528957ENST00000396515RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000457111RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000452530RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000416932RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000470464RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000419893RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000448939RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000457970RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000475528RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000457078RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000412443RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000546690RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000421608RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000486105RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000383588RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000383587RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000400609RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000485585RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000426219RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000421042RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000552867RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000454094RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000494413RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000423247RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000420257RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000456791RPL8chr8

146015154

-ABCF1chr6

30545853

+
intron-intronENST00000528957ENST00000495194RPL8chr8

146015154

-ABCF1chr6

30545853

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394920RPL8chr8146015154-ENST00000326195ABCF1chr630545853+41189657373286849
ENST00000394920RPL8chr8146015154-ENST00000376545ABCF1chr630545853+37859657373172811
ENST00000394920RPL8chr8146015154-ENST00000396515ABCF1chr630545853+2295965156929257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394920ENST00000326195RPL8chr8146015154-ABCF1chr630545853+0.0044470540.99555296
ENST00000394920ENST00000376545RPL8chr8146015154-ABCF1chr630545853+0.0066505180.9933495
ENST00000394920ENST00000396515RPL8chr8146015154-ABCF1chr630545853+0.0079381630.99206185

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Fusion Genomic Features for RPL8-ABCF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPL8chr8146015154-ABCF1chr630545852+3.53E-070.99999964
RPL8chr8146015154-ABCF1chr630545852+3.53E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPL8-ABCF1


check button Go to

FGviewer for the breakpoints of chr8:146015154-chr6:30545853

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCF1

Q8NE71

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCF1chr8:146015154chr6:30545853ENST00000326195225141_24372.0846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000376545224141_24372.0808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000383587024141_2430808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000383588025141_2430846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000412443024141_2430808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000419893025141_2430846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000420257024141_2430808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000421042024141_2430808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000423247025141_2430846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000426219025141_2430846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000448939024141_2430808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000452530024141_2430808.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000457078025141_2430846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000457111025141_2430846.0Compositional biasNote=Glu-rich
TgeneABCF1chr8:146015154chr6:30545853ENST00000326195225304_54872.0846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000326195225625_84072.0846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000376545224304_54872.0808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000376545224625_84072.0808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000383587024304_5480808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000383587024625_8400808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000383588025304_5480846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000383588025625_8400846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000412443024304_5480808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000412443024625_8400808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000419893025304_5480846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000419893025625_8400846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000420257024304_5480808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000420257024625_8400808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000421042024304_5480808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000421042024625_8400808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000423247025304_5480846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000423247025625_8400846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000426219025304_5480846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000426219025625_8400846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000448939024304_5480808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000448939024625_8400808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000452530024304_5480808.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000452530024625_8400808.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000457078025304_5480846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000457078025625_8400846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000457111025304_5480846.0DomainABC transporter 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000457111025625_8400846.0DomainABC transporter 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000326195225336_34372.0846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000326195225658_66572.0846.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000376545224336_34372.0808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000376545224658_66572.0808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000383587024336_3430808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000383587024658_6650808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000383588025336_3430846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000383588025658_6650846.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000412443024336_3430808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000412443024658_6650808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000419893025336_3430846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000419893025658_6650846.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000420257024336_3430808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000420257024658_6650808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000421042024336_3430808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000421042024658_6650808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000423247025336_3430846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000423247025658_6650846.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000426219025336_3430846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000426219025658_6650846.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000448939024336_3430808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000448939024658_6650808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000452530024336_3430808.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000452530024658_6650808.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000457078025336_3430846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000457078025658_6650846.0Nucleotide bindingATP 2
TgeneABCF1chr8:146015154chr6:30545853ENST00000457111025336_3430846.0Nucleotide bindingATP 1
TgeneABCF1chr8:146015154chr6:30545853ENST00000457111025658_6650846.0Nucleotide bindingATP 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RPL8-ABCF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000394920_ENST00000326195_TCGA-HI-7168-01A_RPL8_chr8_146015154_-_ABCF1_chr6_30545853_length(transcript)=4118nt_BP=965nt
TCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGC
TGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAG
AGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCAC
GGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGG
TTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATT
GGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGG
GCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATC
TCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAA
TATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCAC
ATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGA
ACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCACAAAAAAAAAAGCGAGATACCCGAA
AAGGCAGGCGGAAGAAGGATGTGGATGATGATGGAGAAGAGAAAGAGCTCATGGAGCGTCTTAAGAAGCTCTCAGTGCCAACCAGTGATG
AGGAGGATGAAGTACCCGCCCCAAAACCCCGCGGAGGGAAGAAAACCAAGGGTGGTAATGTTTTTGCAGCCCTGATTCAGGATCAGAGTG
AGGAAGAGGAGGAGGAAGAAAAACATCCTCCTAAGCCTGCCAAGCCGGAGAAGAATCGGATCAATAAGGCCGTATCTGAGGAACAGCAGC
CTGCACTCAAGGGCAAAAAGGGAAAGGAAGAGAAGTCAAAAGGGAAGGCTAAGCCTCAAAATAAATTCGCTGCTCTGGACAATGAAGAGG
AGGATAAAGAAGAAGAAATTATAAAGGAAAAGGAGCCTCCCAAACAAGGGAAGGAGAAGGCCAAGAAGGCAGAGCAGGGTTCAGAGGAAG
AAGGAGAAGGGGAAGAAGAGGAGGAGGAAGGAGGAGAGTCTAAGGCAGATGATCCCTATGCTCATCTTAGCAAAAAGGAGAAGAAAAAGC
TGAAAAAACAGATGGAGTATGAGCGCCAAGTGGCTTCATTAAAAGCAGCCAATGCAGCTGAAAATGACTTCTCCGTGTCCCAGGCGGAGA
TGTCCTCCCGCCAAGCCATGTTAGAAAATGCATCTGACATCAAGCTGGAGAAGTTCAGCATCTCCGCTCATGGCAAGGAGCTGTTCGTCA
ATGCAGACCTGTACATTGTAGCCGGCCGCCGCTACGGGCTGGTAGGACCCAATGGCAAGGGCAAGACCACACTCCTCAAGCACATTGCCA
ACCGAGCCCTGAGCATCCCTCCCAACATTGATGTGTTGCTGTGTGAGCAGGAGGTGGTAGCAGATGAGACACCAGCAGTCCAGGCTGTTC
TTCGAGCTGACACCAAGCGATTGAAGCTGCTGGAAGAGGAGCGGCGGCTTCAGGGACAGCTGGAACAAGGGGATGACACAGCTGCTGAGA
GGCTAGAGAAGGTGTATGAGGAATTGCGGGCCACTGGGGCGGCAGCTGCAGAGGCCAAAGCACGGCGGATCCTGGCTGGCCTGGGCTTTG
ACCCTGAAATGCAGAATCGACCCACACAGAAGTTCTCAGGGGGCTGGCGCATGCGTGTCTCCCTGGCCAGGGCACTGTTCATGGAGCCCA
CACTGCTGATGCTGGATGAGCCCACCAACCACCTGGACCTCAACGCTGTCATCTGGCTTAATAACTACCTCCAGGGCTGGCGGAAGACCT
TGCTGATCGTCTCCCATGACCAGGGCTTCTTGGATGATGTCTGCACTGATATCATCCACCTCGATGCCCAGCGGCTCCACTACTATAGGG
GCAATTACATGACCTTCAAAAAGATGTACCAGCAGAAGCAGAAAGAACTGCTGAAACAGTATGAGAAGCAAGAGAAAAAGCTGAAGGAGC
TGAAGGCAGGCGGGAAGTCCACCAAGCAGGCGGAAAAACAAACGAAGGAAGCCCTGACTCGGAAGCAGCAGAAATGCCGACGGAAAAACC
AAGATGAGGAATCCCAGGAGGCCCCTGAGCTCCTGAAGCGCCCTAAGGAGTACACTGTGCGCTTCACTTTTCCAGACCCCCCACCACTCA
GCCCTCCAGTGCTGGGTCTGCATGGTGTGACATTCGGCTACCAGGGACAGAAACCACTCTTTAAGAACTTGGATTTTGGCATCGACATGG
ATTCAAGGATTTGCATTGTGGGCCCTAATGGTGTGGGGAAGAGTACGCTACTCCTGCTGCTGACTGGCAAGCTGACACCGACCCATGGGG
AAATGAGAAAGAACCACCGGCTGAAAATTGGCTTCTTCAACCAGCAGTATGCAGAGCAGCTGCGCATGGAGGAGACGCCCACTGAGTACC
TGCAGCGGGGCTTCAACCTGCCCTACCAGGATGCCCGCAAGTGCCTGGGCCGCTTCGGCCTGGAGAGTCACGCCCACACCATCCAGATCT
GCAAACTCTCTGGTGGTCAGAAGGCGCGAGTTGTGTTTGCTGAGCTGGCCTGTCGGGAACCTGATGTCCTCATCTTGGACGAGCCAACCA
ATAACCTGGACATAGAGTCTATTGATGCTCTAGGGGAGGCCATCAATGAATACAAGGGTGCTGTGATCGTTGTCAGCCATGATGCCCGAC
TCATCACAGAAACCAATTGCCAGCTGTGGGTGGTGGAGGAGCAGAGTGTTAGCCAAATCGATGGTGACTTTGAAGACTACAAGCGGGAGG
TGTTGGAGGCCCTGGGTGAAGTCATGGTCAGCCGGCCCCGAGAGTGAGCTTTCCTTCCCAGAAGTCTCCCGAGAGACATATTTGTGTGGC
CTAGAAGTCCTCTGTGGTCTCCCCTCCTCTGAAGACTGCCTCTGGCCTGCAGCTGACCTGGCAACCATTCAGGCACATGAAGGTGGAGTG
TGACCTTGATGTGACCGGGATCCCACTCTGATTGCATCCATTTCTCTGAAAGACTTGTTTGTTCTGCTTCTCTTCATATAACTGAGCTGG
CCTTATCCTTGGCATCCCCCTAAACAAACAAGAGGTGACCACCTTATTGTGAGGTTCCATCCAGCCAAGTTTATGTGGCCTATTGTCTCA
GGACTCTCATCACTCAGAAGCCTGCCTCTGATTTACCCTACAGCTTCAGGCCCAGCTGCCCCCCAGTCTTTGGGTGGTGCTGTTCTTTTC
TGGTGGATTTAATGCTGACTCACTGGTACAAACAGCTGTTGAAGCTCAGAGCTGGAGGTGAGCTTCTGAGGCCTTTGCCATTATCCAGCC
CAAGATTTGGTGCCTGCAGCCTCTTGTCTGGTTGAGGACTTGGGGCAGGAAAGGAATGCTGCTGAACTTGAATTTCCCTTTACAAGGGGA
AGAAATAAAGGAAAGGAGTTGCTGCCGACCTGTCACTGTTTGGAGATTGATGGGAGTTGGAACTGTTCTCAGTCTTGATTTGCTTTATTC
AGTTTTCTAGCAGCTTTTAATAGTCCCCTCTTCCCCACTAAATGGATCTTGTTTGCAGTCTTGCTGACAGTGTTTGCTGTTTAAGGATCA

>In-frame_ENST00000394920_ENST00000326195_TCGA-HI-7168-01A_RPL8_chr8_146015154_-_ABCF1_chr6_30545853_length(amino acids)=849AA_start in transcript=737_stop in transcript=3286
MLATSTGCGHESCGASFWRWQPPAHRQALHHPQRCPCWPQSGSHCCPPDWTSPGNQDCAGERELVLRASIKFVFMPQKKKRDTRKGRRKK
DVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGK
KGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQME
YERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSI
PPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQN
RPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTF
KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLG
LHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFN
LPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETN

--------------------------------------------------------------
>In-frame_ENST00000394920_ENST00000376545_TCGA-HI-7168-01A_RPL8_chr8_146015154_-_ABCF1_chr6_30545853_length(transcript)=3785nt_BP=965nt
TCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGC
TGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAG
AGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCAC
GGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGG
TTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATT
GGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGG
GCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATC
TCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAA
TATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCAC
ATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGA
ACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCACAAAAAAAAAAGCGAGATACCCGAA
AAGGCAGGCGGAAGAAGGATGTGGATGATGATGGAGAAGAGAAAGAGCTCATGGAGCGTCTTAAGAAGCTCTCAGTGCCAACCAGTGATG
AGGAGGATGAAGTACCCGCCCCAAAACCCCGCGGAGGGAAGAAAACCAAGGGTGGTAATGTTTTTGCAGCCCTGATTCAGGATCAGAGTG
AGGAAGAGGAGGAGGAAGAAAAACATCCTCCTAAGCCTGCCAAGCCGGAGAAGAATCGGATCAATAAGGCCGTATCTGAGGAACAGCAGC
CTGCACTCAAGGGCAAAAAGGGAAAGGAAGAGAAGTCAAAAGGGAAGGCTAAGCCTCAAAATAAATTCGCTGCTCTGGACAATGAAGAGG
AGGATAAAGAAGAAGAAATTATAAAGGAAAAGGAGCCTCCCAAACAAGGGAAGGAGAAGGCCAAGAAGGCAGAGCAGATGGAGTATGAGC
GCCAAGTGGCTTCATTAAAAGCAGCCAATGCAGCTGAAAATGACTTCTCCGTGTCCCAGGCGGAGATGTCCTCCCGCCAAGCCATGTTAG
AAAATGCATCTGACATCAAGCTGGAGAAGTTCAGCATCTCCGCTCATGGCAAGGAGCTGTTCGTCAATGCAGACCTGTACATTGTAGCCG
GCCGCCGCTACGGGCTGGTAGGACCCAATGGCAAGGGCAAGACCACACTCCTCAAGCACATTGCCAACCGAGCCCTGAGCATCCCTCCCA
ACATTGATGTGTTGCTGTGTGAGCAGGAGGTGGTAGCAGATGAGACACCAGCAGTCCAGGCTGTTCTTCGAGCTGACACCAAGCGATTGA
AGCTGCTGGAAGAGGAGCGGCGGCTTCAGGGACAGCTGGAACAAGGGGATGACACAGCTGCTGAGAGGCTAGAGAAGGTGTATGAGGAAT
TGCGGGCCACTGGGGCGGCAGCTGCAGAGGCCAAAGCACGGCGGATCCTGGCTGGCCTGGGCTTTGACCCTGAAATGCAGAATCGACCCA
CACAGAAGTTCTCAGGGGGCTGGCGCATGCGTGTCTCCCTGGCCAGGGCACTGTTCATGGAGCCCACACTGCTGATGCTGGATGAGCCCA
CCAACCACCTGGACCTCAACGCTGTCATCTGGCTTAATAACTACCTCCAGGGCTGGCGGAAGACCTTGCTGATCGTCTCCCATGACCAGG
GCTTCTTGGATGATGTCTGCACTGATATCATCCACCTCGATGCCCAGCGGCTCCACTACTATAGGGGCAATTACATGACCTTCAAAAAGA
TGTACCAGCAGAAGCAGAAAGAACTGCTGAAACAGTATGAGAAGCAAGAGAAAAAGCTGAAGGAGCTGAAGGCAGGCGGGAAGTCCACCA
AGCAGGCGGAAAAACAAACGAAGGAAGCCCTGACTCGGAAGCAGCAGAAATGCCGACGGAAAAACCAAGATGAGGAATCCCAGGAGGCCC
CTGAGCTCCTGAAGCGCCCTAAGGAGTACACTGTGCGCTTCACTTTTCCAGACCCCCCACCACTCAGCCCTCCAGTGCTGGGTCTGCATG
GTGTGACATTCGGCTACCAGGGACAGAAACCACTCTTTAAGAACTTGGATTTTGGCATCGACATGGATTCAAGGATTTGCATTGTGGGCC
CTAATGGTGTGGGGAAGAGTACGCTACTCCTGCTGCTGACTGGCAAGCTGACACCGACCCATGGGGAAATGAGAAAGAACCACCGGCTGA
AAATTGGCTTCTTCAACCAGCAGTATGCAGAGCAGCTGCGCATGGAGGAGACGCCCACTGAGTACCTGCAGCGGGGCTTCAACCTGCCCT
ACCAGGATGCCCGCAAGTGCCTGGGCCGCTTCGGCCTGGAGAGTCACGCCCACACCATCCAGATCTGCAAACTCTCTGGTGGTCAGAAGG
CGCGAGTTGTGTTTGCTGAGCTGGCCTGTCGGGAACCTGATGTCCTCATCTTGGACGAGCCAACCAATAACCTGGACATAGAGTCTATTG
ATGCTCTAGGGGAGGCCATCAATGAATACAAGGGTGCTGTGATCGTTGTCAGCCATGATGCCCGACTCATCACAGAAACCAATTGCCAGC
TGTGGGTGGTGGAGGAGCAGAGTGTTAGCCAAATCGATGGTGACTTTGAAGACTACAAGCGGGAGGTGTTGGAGGCCCTGGGTGAAGTCA
TGGTCAGCCGGCCCCGAGAGTGAGCTTTCCTTCCCAGAAGTCTCCCGAGAGACATATTTGTGTGGCCTAGAAGTCCTCTGTGGTCTCCCC
TCCTCTGAAGACTGCCTCTGGCCTGCAGCTGACCTGGCAACCATTCAGGCACATGAAGGTGGAGTGTGACCTTGATGTGACCGGGATCCC
ACTCTGATTGCATCCATTTCTCTGAAAGACTTGTTTGTTCTGCTTCTCTTCATATAACTGAGCTGGCCTTATCCTTGGCATCCCCCTAAA
CAAACAAGAGGTGACCACCTTATTGTGAGGTTCCATCCAGCCAAGTTTATGTGGCCTATTGTCTCAGGACTCTCATCACTCAGAAGCCTG
CCTCTGATTTACCCTACAGCTTCAGGCCCAGCTGCCCCCCAGTCTTTGGGTGGTGCTGTTCTTTTCTGGTGGATTTAATGCTGACTCACT
GGTACAAACAGCTGTTGAAGCTCAGAGCTGGAGGTGAGCTTCTGAGGCCTTTGCCATTATCCAGCCCAAGATTTGGTGCCTGCAGCCTCT
TGTCTGGTTGAGGACTTGGGGCAGGAAAGGAATGCTGCTGAACTTGAATTTCCCTTTACAAGGGGAAGAAATAAAGGAAAGGAGTTGCTG

>In-frame_ENST00000394920_ENST00000376545_TCGA-HI-7168-01A_RPL8_chr8_146015154_-_ABCF1_chr6_30545853_length(amino acids)=811AA_start in transcript=737_stop in transcript=3172
MLATSTGCGHESCGASFWRWQPPAHRQALHHPQRCPCWPQSGSHCCPPDWTSPGNQDCAGERELVLRASIKFVFMPQKKKRDTRKGRRKK
DVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGK
KGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDI
KLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEE
RRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDL
NAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQ
TKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGK
STLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFA
ELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPR

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>In-frame_ENST00000394920_ENST00000396515_TCGA-HI-7168-01A_RPL8_chr8_146015154_-_ABCF1_chr6_30545853_length(transcript)=2295nt_BP=965nt
TCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGC
TGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAG
AGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCAC
GGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGG
TTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATT
GGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGG
GCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATC
TCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAA
TATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCAC
ATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGA
ACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCACAAAAAAAAAAGCGAGATACCCGAA
AAGGCAGGCGGAAGAAGGATGTGGATGATGATGGAGAAGAGAAAGAGCTCATGGAGCGTCTTAAGAAGCTCTCACGGGGCTTCAACCTGC
CCTACCAGGATGCCCGCAAGTGCCTGGGCCGCTTCGGCCTGGAGAGTCACGCCCACACCATCCAGATCTGCAAACTCTCTGGTGGTCAGA
AGGCGCGAGTTGTGTTTGCTGAGCTGGCCTGTCGGGAACCTGATGTCCTCATCTTGGACGAGCCAACCAATAACCTGGACATAGAGTCTA
TTGATGCTCTAGGGGAGGCCATCAATGAATACAAGGGTGCTGTGATCGTTGTCAGCCATGATGCCCGACTCATCACAGAAACCAATTGCC
AGCTGTGGGTGGTGGAGGAGCAGAGTGTTAGCCAAATCGATGGTGACTTTGAAGACTACAAGCGGGAGGTGTTGGAGGCCCTGGGTGAAG
TCATGGTCAGCCGGCCCCGAGAGTGAGCTTTCCTTCCCAGAAGTCTCCCGAGAGACATATTTGTGTGGCCTAGAAGTCCTCTGTGGTCTC
CCCTCCTCTGAAGACTGCCTCTGGCCTGCAGCTGACCTGGCAACCATTCAGGCACATGAAGGTGGAGTGTGACCTTGATGTGACCGGGAT
CCCACTCTGATTGCATCCATTTCTCTGAAAGACTTGTTTGTTCTGCTTCTCTTCATATAACTGAGCTGGCCTTATCCTTGGCATCCCCCT
AAACAAACAAGAGGTGACCACCTTATTGTGAGGTTCCATCCAGCCAAGTTTATGTGGCCTATTGTCTCAGGACTCTCATCACTCAGAAGC
CTGCCTCTGATTTACCCTACAGCTTCAGGCCCAGCTGCCCCCCAGTCTTTGGGTGGTGCTGTTCTTTTCTGGTGGATTTAATGCTGACTC
ACTGGTACAAACAGCTGTTGAAGCTCAGAGCTGGAGGTGAGCTTCTGAGGCCTTTGCCATTATCCAGCCCAAGATTTGGTGCCTGCAGCC
TCTTGTCTGGTTGAGGACTTGGGGCAGGAAAGGAATGCTGCTGAACTTGAATTTCCCTTTACAAGGGGAAGAAATAAAGGAAAGGAGTTG
CTGCCGACCTGTCACTGTTTGGAGATTGATGGGAGTTGGAACTGTTCTCAGTCTTGATTTGCTTTATTCAGTTTTCTAGCAGCTTTTAAT
AGTCCCCTCTTCCCCACTAAATGGATCTTGTTTGCAGTCTTGCTGACAGTGTTTGCTGTTTAAGGATCATAGGATTCCTTTCCCCCAACC

>In-frame_ENST00000394920_ENST00000396515_TCGA-HI-7168-01A_RPL8_chr8_146015154_-_ABCF1_chr6_30545853_length(amino acids)=257AA_start in transcript=156_stop in transcript=929
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYC
GKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL

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Fusion Gene PPI Analysis for RPL8-ABCF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL8-ABCF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL8-ABCF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCF1C0020517Hypersensitivity1CTD_human
TgeneABCF1C0032285Pneumonia1CTD_human
TgeneABCF1C0032300Lobar Pneumonia1CTD_human
TgeneABCF1C0235874Disease Exacerbation1CTD_human
TgeneABCF1C0887898Experimental Lung Inflammation1CTD_human
TgeneABCF1C1527304Allergic Reaction1CTD_human
TgeneABCF1C3714636Pneumonitis1CTD_human