FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RPL8-FMN1 (FusionGDB2 ID:76574)

Fusion Gene Summary for RPL8-FMN1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL8-FMN1
Fusion gene ID: 76574
HgeneTgene
Gene symbol

RPL8

FMN1

Gene ID

6132

342184

Gene nameribosomal protein L8formin 1
SynonymsL8FMN|LD
Cytomap

8q24.3

15q13.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L8large ribosomal subunit protein uL2formin-1formin (limb deformity)limb deformity protein homolog
Modification date2020032720200313
UniProtAcc.

Q68DA7

Ensembl transtripts involved in fusion geneENST00000529163, ENST00000394920, 
ENST00000527914, ENST00000262584, 
ENST00000528957, 		ENST00000334528, 
ENST00000561249, ENST00000559047, 
ENST00000558197, ENST00000559150, 
ENST00000320930, 
Fusion gene scores* DoF score36 X 18 X 15=97209 X 8 X 4=288
# samples 379
** MAII scorelog2(37/9720*10)=-4.71535913797683
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL8 [Title/Abstract] AND FMN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL8(146015154)-FMN1(33096533), # samples:1
Anticipated loss of major functional domain due to fusion event.RPL8-FMN1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL8-FMN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL8

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across RPL8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FMN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A29Q-06ARPL8chr8

146015154

-FMN1chr15

33096533

-


Top

Fusion Gene ORF analysis for RPL8-FMN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000529163ENST00000334528RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000529163ENST00000561249RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000529163ENST00000559047RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000529163ENST00000558197RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000529163ENST00000559150RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000529163ENST00000320930RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000394920ENST00000334528RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000394920ENST00000561249RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000394920ENST00000559047RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000394920ENST00000558197RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000394920ENST00000559150RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000394920ENST00000320930RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000527914ENST00000334528RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000527914ENST00000561249RPL8chr8

146015154

-FMN1chr15

33096533

-
Frame-shiftENST00000527914ENST00000559047RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000527914ENST00000558197RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000527914ENST00000559150RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000527914ENST00000320930RPL8chr8

146015154

-FMN1chr15

33096533

-
In-frameENST00000262584ENST00000334528RPL8chr8

146015154

-FMN1chr15

33096533

-
In-frameENST00000262584ENST00000561249RPL8chr8

146015154

-FMN1chr15

33096533

-
In-frameENST00000262584ENST00000559047RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000262584ENST00000558197RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000262584ENST00000559150RPL8chr8

146015154

-FMN1chr15

33096533

-
5CDS-intronENST00000262584ENST00000320930RPL8chr8

146015154

-FMN1chr15

33096533

-
intron-3CDSENST00000528957ENST00000334528RPL8chr8

146015154

-FMN1chr15

33096533

-
intron-3CDSENST00000528957ENST00000561249RPL8chr8

146015154

-FMN1chr15

33096533

-
intron-3CDSENST00000528957ENST00000559047RPL8chr8

146015154

-FMN1chr15

33096533

-
intron-intronENST00000528957ENST00000558197RPL8chr8

146015154

-FMN1chr15

33096533

-
intron-intronENST00000528957ENST00000559150RPL8chr8

146015154

-FMN1chr15

33096533

-
intron-intronENST00000528957ENST00000320930RPL8chr8

146015154

-FMN1chr15

33096533

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262584RPL8chr8146015154-ENST00000334528FMN1chr1533096533-1013710412331006257
ENST00000262584RPL8chr8146015154-ENST00000561249FMN1chr1533096533-153210412331006257
ENST00000262584RPL8chr8146015154-ENST00000559047FMN1chr1533096533-137310412331006257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262584ENST00000334528RPL8chr8146015154-FMN1chr1533096533-0.0013885560.99861145
ENST00000262584ENST00000561249RPL8chr8146015154-FMN1chr1533096533-0.006867110.9931329
ENST00000262584ENST00000559047RPL8chr8146015154-FMN1chr1533096533-0.0080364830.9919635

Top

Fusion Genomic Features for RPL8-FMN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RPL8-FMN1


check button Go to

FGviewer for the breakpoints of chr8:146015154-chr15:33096533

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FMN1

Q68DA7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFMN1chr8:146015154chr15:33096533ENST0000032093005720_7740663.0Coiled coilOntology_term=ECO:0000255
TgeneFMN1chr8:146015154chr15:33096533ENST0000055819702720_7740504.0Coiled coilOntology_term=ECO:0000255
TgeneFMN1chr8:146015154chr15:33096533ENST0000032093005869_9840663.0Compositional biasNote=Pro-rich
TgeneFMN1chr8:146015154chr15:33096533ENST0000055819702869_9840504.0Compositional biasNote=Pro-rich
TgeneFMN1chr8:146015154chr15:33096533ENST0000032093005870_9570663.0DomainNote=FH1
TgeneFMN1chr8:146015154chr15:33096533ENST0000032093005972_13880663.0DomainFH2
TgeneFMN1chr8:146015154chr15:33096533ENST0000055819702870_9570504.0DomainNote=FH1
TgeneFMN1chr8:146015154chr15:33096533ENST0000055819702972_13880504.0DomainFH2
TgeneFMN1chr8:146015154chr15:33096533ENST00000320930051_6220663.0RegionMicrotubule-binding
TgeneFMN1chr8:146015154chr15:33096533ENST00000558197021_6220504.0RegionMicrotubule-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFMN1chr8:146015154chr15:33096533ENST000003345281217720_7741086.33333333333331197.0Coiled coilOntology_term=ECO:0000255
TgeneFMN1chr8:146015154chr15:33096533ENST000005590471318720_7741309.33333333333331420.0Coiled coilOntology_term=ECO:0000255
TgeneFMN1chr8:146015154chr15:33096533ENST000003345281217869_9841086.33333333333331197.0Compositional biasNote=Pro-rich
TgeneFMN1chr8:146015154chr15:33096533ENST000005590471318869_9841309.33333333333331420.0Compositional biasNote=Pro-rich
TgeneFMN1chr8:146015154chr15:33096533ENST000003345281217870_9571086.33333333333331197.0DomainNote=FH1
TgeneFMN1chr8:146015154chr15:33096533ENST000003345281217972_13881086.33333333333331197.0DomainFH2
TgeneFMN1chr8:146015154chr15:33096533ENST000005590471318870_9571309.33333333333331420.0DomainNote=FH1
TgeneFMN1chr8:146015154chr15:33096533ENST000005590471318972_13881309.33333333333331420.0DomainFH2
TgeneFMN1chr8:146015154chr15:33096533ENST0000033452812171_6221086.33333333333331197.0RegionMicrotubule-binding
TgeneFMN1chr8:146015154chr15:33096533ENST0000055904713181_6221309.33333333333331420.0RegionMicrotubule-binding


Top

Fusion Gene Sequence for RPL8-FMN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262584_ENST00000334528_TCGA-EE-A29Q-06A_RPL8_chr8_146015154_-_FMN1_chr15_33096533_length(transcript)=10137nt_BP=1041nt
ACCAGGACACCTTCAGCCGCGTCTCCTGGTGCGCCTGCGCGGGGGCCCTGGAGGAGGAGAAGTAGGCGGGGCCGGCGGCCGCTGGTGACT
ACAAGCCCCGGCGTGCACCGCGCTAGGCTGGCCGTGGCGCGCCCGGAAGGTGTCGCGGCCCTGGGCCCCGCCCCGGAAGATAAGGCCGCT
CGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCG
GGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGG
GCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGGTTTAAGAAGCGGA
CGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATTGGCAATGTGCTCC
CTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGGGCATCAGGGAACT
ATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATCTCCTCAGCCAACA
GAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAATATAAGGCAAAGA
GGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCACATCGGCAAGCCCT
CCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGAACCAAGACTGTGC
AGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCCCAAAAAAGAGCATAAGATGGAAGAAAGTCACTTGGAGA
ATGCACAGAAAAGTTTTGAAACAACAGTACGATATTTTGGGATGAAGCCAAAGTCTGGTGAGAAGGAGATCACACCCAGCTACGTGTTTA
TGGTGTGGTATGAGTTCTGCAGTGACTTCAAGACAATTTGGAAACGGGAGAGTAAAAACATATCTAAAGAAAGATTGAAAATGGCTCAGG
AATCAGTCAGCAAGTTGACTTCAGAGAAGAAAGTGGAGACAAAGAAAATCAATCCCACTGCTAGCCTGAAAGAAAGACTGCGTCAGAAGG
AAGCCAGTGTGACCACTAACTAAGATGAAGACACATGGAAATGATGGCACTGGAGGTGGAGGACCTTGCACGCATACTCTTTGTGACCAC
AGGGTTGCAGGACGTTCTTGAAAGATGTGTCACTAAATGTTTGTTTTTGCTCATCTCTTTCTGAGGTCATCTGCAGAGAGTGCCCCATGC
CTTCTTTAAGAAGTCCCTCATTAAGCCGCAGGAACAATGGAAAACTATTTAAGGGAACATTGCAGAAATATTTGATGACTGTTTCTTGTG
GAAGCCCAAAGTCCACTCTAAGAGCAGAAGAAATACCAAAATGTTTCCAAAATTTTTTTAAAAGCTGAGATTTCCAGCTTTATAACCAAA
GCTTGATATATGTCACATTGTCACAGAAGAGAGAAAAGATCATTGAGGACAGTTGCCTTGGGAGAGTTCAAGTCTTTGTCGTTACACACT
GCTGTTTTGATTATTGGTCTTAGTTTTGATCCTGTTGCAGCAAAATCCTGCAGCATCTTTCTCTCCAATAATGTTGCAACTCACCAAAAC
TATTCTTGAAGAGGTCCAAGAACATGTATTATCCAGACTAAAAAAATGATTTTTTGTTGTTATGGTTTACGTGATGAAAAGGAGAAAAAA
CAGAATCATACCTGGGTGGAGAGAGGGAGACAAATAGCCATAAACTTCATCCTGGAGAACAAGTTACCATGCAAGGAGTTGACATCAGTT
GTTAAGTGAGGCCCATTCTTGTTTTTACATCGGTCCTTTGTGGTTTTTCTGGGCCAGCAGAGATTCTGCACCCCAACTCCCAGGAGAAAA
TGTAATACCTGAGCAAGCACAGCCTTGGGTGTGCTTGGACAAGAGACCCAGCGGCAGAGCACCTTTTACATTTTGGACCGTTCATGAATG
GGCAATGTTGTGTTGATACGCAGCCGAGTTCTACGTTATGTGCTGTGACTGTGCAGCTGGACGACCCCCATCCCCAGGAGGCAGTTTCCA
GACAGGAGAGCAAATGCAACTCACAGCACCTGCTCATGACCTTGGCTGATAGGCATGTGAAGTAGGATGAAGCAGGACTCTTTAATGTCA
AAAAAACTGAAGGGCAGAAAAAAGGTTCCTTACATCAAAATGAAAGTAATTACATTAATAGAAAACTTCCAAGTGGAATATTGTTCACAG
GCAGCTCTTTCTGACCCTGGCTCTTGAGTCACATAAGGAAACCACCTTTGACCTCTCTGACACTTTTGTCTTTAAGCCACGTCTCTGAAA
TCTTGTGAGGGGTGAAGAAAGAGGACTGGAGATGAATGGACAATATGATCAAAGACTCATTTTTAGGCCTTGAAGAGGCCGAGCTTTCTC
CCCCCAATTGGTGGAGGACAGTCCAGAGATGAGCAGAAATCTTAAATTCCTTCCTGATCCAGCCTCCACATGTGGCCTGCCCCTTGCCCC
AGCATCTTTCCAGAACCCCTGGACTTGCCAGGTGCCTGAGCATCTTCCCAGGATATGCCTGCCAGCCAGCAGCCCCTCAGGAATGCTTCT
ATAATAGATCCAGTAATGAAAGCAGCACCATATCCTAATCTAATGTCAGCTTCGAGAATGAAGACTGCAGTCAGGATCAAATCAAGTCAC
AGAAGCCATATTCATGCAGGTGCTAACCGCCTTTTCTACTGGTGCAACTGAAAGGAATATGGTAACATGGTTGGATTTTTAAAATTCACA
ATGAAGGAACGAGACAAGCAAAACAGAAAAGCCGAGAAGGAACATGCATGACTAAAAAGGCTTGAAGTTGCTTGTGAGCAAGAAGCTTTT
TATGCTGCTTTCTTACATAGTTTCTCTTCATTTTCACTTAACTCTGAAGACAACCAAAAGAACGGATCAATTAAAAACTGATTCCACTTA
TAACCATTGTATGCTCCTTCTAGTGTTATCATGCACAAGAAAAGTGCCAGTTTTACCCATGCCATATAATTCAGCTCTTTTGAGTTATGT
GGGGCCAGCAGAAGTCTCAATCCTTATAGGCTTGATGGTGAGAGCAGCGGGAGGTTTGAGGTGTACTCATTGCAGTCCACTTTGGTCTGT
AAGTAGGATGCTTACGAGAAATCAGTGAAGGTAAGCAGGGCTGCCACTGTGGCCACGTAACCCTTCAGGAACCAGTGCTGAAGAATAATG
AGTGAGAACACTTAATTTGAGAGTTAGACAAATACAGCCCACTTTGGATTTCATCCTAGTGAACAGACTAAAACTTTGCAGTAAAATACC
TATTTCTACAAAGCAAGGTTTGCCTGCCTCGGTTGGGGAAACCTAGTGGTTTTGTCACACTAGTCGATGTATGATGTTAGTGTTGTAAGA
CACCATGGCAGAATCTTCATTATTCTCACCTATTCTGAACCCTGCATCATGTATCTGGGATGCCCCCTCCCAAGTCCACCAATGTACCAC
GTTGCTGACACAGCCTTCATTTTTAACTCAAATTGATGCTCAGTAAAGGTCAATGACAATTTGTTCAAGGAAGTTCATCTAAAATAATCT
GGAGGCCTTGAAAATGATCCCTCTAAAATGCTGTTGAGCTTGTGTTCAGTGTAGCAGGAGGATCTGAACTTTTCCTGGAGAGGAGGTGAT
CGGGATGCCATTTGGCAGCTTAAGCACATCCTGCCAGCAGGCTTTAAGTGGCTGTTCTAGGCATAGCCCTCCCTGAACTAGAAAGGAGAG
TAACCAGTTTGCTATGCTGCATCTAACCAGACACACCTGACTTAGTAGTAACTCTAAGAACCCTTAACTTACAAACAACTTTGTCTCCTC
TTAGACAATATTCATTAAATCTGAGGACACAGTTTGACAGTAGTTCAGATTCTTGCATGAGCAATTGACAGCATCAGAGCACACAATATC
ATAAGTTACATAAATTACACAAAGTACATCATAAATTACACTACAGACACGTTAGGTAAAAAGCATCAGGCCCGGGCCGGGCGTGGTGGC
TCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGCGGGGGCGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAA
CCCCATCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAAT
GGCGTGAACCCAGGAGGTGGAGCTTGCAGCTAGCCGAGATAGCACCACTGCACTCCAGCCTGGGCGACAGTGAGACTCCGTTTCAAAAAA
AAAAGCATCAGGCCCATGAAGTATCAAAAACCAGGTTAGGAGGTGTGCTGTATGGCTTTTATCTCAATAAGTGGCAGCTTACTGGGGAAA
AAGAAATAAGAAAAAGTGTGGCCAAGCAGAAGTGGATGTTTATGATGACGGTGGGGGCCCAGAGGTCATAGGTGATGGTCCTACTGCCCA
ACAGTTGCCTTTTGAATCCTTATGTTGATGATGGTGTCTTTCTACACACTCACTGCAACTACTCAGGAATTATAAAGATTTTCTGAAATC
TGAGAAGTGGAATAAGGAAACCCAGTGGAGCTATTACACTTTTAAATGTTCTAGCCAAAACAAATTGCCAGTATGGTTGAGGAATTGAAT
ATCAGATGGCATGCAGTCTCCCCTCCCCTCCCCTATCAAGGACAGTAGAAGCTGCAAACCTCTTCTCAGCCTCCTTCAGGCACCTCCTGT
TTTCATAAGCACCATGAAGAATGGTGTTTCCTAAATGAAAAGTTCAGATACTGCTGGTAAAGAAACTGGAAAAACTGAAGGAAGGAATAA
AATATGTTGGTGGTATTAACACCTCCAGTAAGATAAGTCATTGGTACGGTTTTTCTAAGGGCCGCAGTGAGATGTAGCAGAAGAAATATG
TTTATTTTGGGCAAAGATTTGCTTATTGGCCTGGGATTGCACATTTTCTCTATGATGTTTGCAACAGAGAAATTTTCATTTTAATGATAC
TCTTCCTTTCTTGAAAGTTACATGTCCTCATTTCTGTTTCTGCTTCTCCCTTGGCCAGTGTCATTGATGCAGATCATTGCATACAACAGC
ACAGCAAATTGCGCCAAGTCAGTGTGTGAATGGGAATTAGCAATGCACGCTTGCAGGCTCTTTTTCCAGGAACCAGGCTGTAACATTGAC
CGGGGAACCTCTTCATTCCCTGACATACTAAATTGGTCAATTTTGTAGTACTCATCTCCATCCACAAAAACAACAAAGATAAAATCAATT
TGGAGCTTTATATGACAAAAAGGAAGAAGTCCAAAAATATATAGCCTTCCCCCCTCCCACATATCTGATCCAAATATTAAATATCTGATT
TTATAAAACAGTTTAAATTGTCTTTTTAAATTGCTAACAAGCATCAGTTATATTTGAGCTTCATTTTTCTTTTATCCTGTCTGTCCTAAT
AAAAACAAAAATGGCCAAAAAGTGGAGAGGAAAGAAAAAGCTTCCACTTTTTAAAATTTGTTTTGTATTAGTTATTTTACCTTTAGGGAC
CCTACAACTGAAGAGAGTGGAGAGAATAAAGAAGTGAACTTTCATTCATGTCTGCTACTTTGACCTCATAAAGAAATCTGCAACACAGAT
GAAACCAGTCTGTGTGGCCAAGCTGATGGGATTTGAAAAGAGTGGATAATTTTTAGCCTTTCCAAAATGCAAATAACTTGGATATATTTC
CATTTTCCAGCTATAGAGAGAAACAATCCAGCTGCCTGGAAACTGTTATTAGTATAGAAGTGGCTTAAAGAAAAGCATCTTCAAATACTT
GACTTAGCATATCTTTCTTCTTTAGACTTACATAATGATATTCATCTCTCCATTAGCAATTGAATCCAGGCATAACCGGGCTCAGTTACA
CAGCTTGTCTGTGACTGGGAAGCCCATTTTGTGTCATTTCTGCACACCTGTCCGCTGTTGACACCTTATTAGAGGCACTGCATTTTGGTT
TCACAATTCTTCATCTCCCTTCCCAAGGAATGGGCAATCTACTGAACTTCCAGATCAATGCTTTGTTGGAAAGTGATGAATTTAAGAGAG
TTTTAACATGTCAAATTTGAAGCCAATTCAGTATCCTTATTTGTTCCAAGACTCTTAACCAATACTGTGATATAAAGTTAGGATTTGGGA
AACGTGTAGTTAACAACTTGGAAACATGAAGATATTAAAATGGCAGCTGGCTAACTGTCTCTTAAGCCACTATGCAATTTCTACCAATGG
AGAGATTAGGGAAGCAAATTAAGCCTCATTCAGTAGGTCTGCTGTCTGGTGGAACTTACGGAACTCATTTCCTCCTCTATCCCCAGCCCT
TCTCCTAACTATGGTGATAACCAGGGCCATAGAAGACCTTTTCTCTCTTACCTTTCTCTGATAGGATCGTGTCCTTCAGTCAAGAGCTCA
TGTGAACTCCAGACTTTATATTACATCTCTGAAGTTCTTGATGTGGGGAAGATTGACTTTTATTCCATTTTTATATGAAGGTGTTAGATA
TAGCCATCAATTTATTTTTCTACATTCCCTCTACGCTTATGTAATTTTCTATTTTTAAATCTTCTCTTAAATATACTGAGAATCTCTAGT
CTCCTTTTCTAAAGGCTGATCCAACTACACTTGTGGGCTATTTTTCCAAGCTTTGTGTGAAACTTGATGACATTGGGCCAGCAAAATGCA
AAGAAGACTATAGTTTCAGGCAGAAAATCACGTCCAAAGAATTTGGCATGGATTAAACAACCTCTACCACACTATAGCTCTCACATAGGC
TGAACATTTTCCTAAATTCTACCTGTGCAGACACTGAGGGGCTCTCTACCTTTGAAACTATGAGAACGTCTTAAATTAATATGAATATTT
CTCTCCATGTATAGTGTGAGCTGCCAATGCATTATCTTAATACATCAAGAAGGAAATCAGATTTCAGGCACACATTAGCAATTGTTTGTT
AATGTCCTTGGCAAACGTGTACCTGCTTTCCTTCATTGTTCTCTTCAGGGGCTTTCTTCCACTTTCCTCTTATGAAACGAATGTGTTTTT
GACTGTTAACTGGGTTCGCTTTCCAGATCTGTCTTTCCCAAATGAAAGGTTAGTCCCATAGACCACTGGCTATTCAGGGAAATTACTCTC
TACCTCCCCATGACATGGATGATAAGTGTTGAGGGATGAACACTCTGGAAACTCTTAGCATGGATTTTGAATTCCAGATTTCTTTATAGG
AGATGTATAAAAAGGAGTTTATAGCATACAAAAATTATACTGCTCTTCCCAGTAAGGGACTAAAAGGACATTTGAAATCTTTACATTTTA
GATGTTTTTGTGAATTATAAATATCTCCTTTTTCCTCGCTTCATGCTAACTTGTCTCTAGATAAAATCTTATTTCTTCATACATTGGACC
ACAAGGCATAAAGAAGGTAGCTCAGCGCCACTGAGATTGTGTTCTGCATAATATTTGGAAGGCTTCCATTTCCATTGAAAACAAATCCAT
GAGTGAGAGGGAAAGTCTAGTATCAATTCTTCTGTTTGCTCGCAATGACACAAATAGGTTTTGGGGATCTACCTAAGGGATAGGTCTACT
CCAAAATTATTAAATTTATAATTGTGCAATTCTGTAATTTCCCAAGGCATAAGTAATATGACCCTACTGTCAGCTAGATGTCTTATCTTC
AAAGAGAGTATGCATTAATAAAAAGAACTTCCCTTTAAAGAACCAATCTAAAATACTAAAAAGGCAGAAACTTTTAAAATTAGAAATTGG
ATAATTTTTAAGAATCTTTAGAGAAAACATTGGTTTATCATAGTCTTTTTCTTTCATTGAGTTTTCATTTAGACTAGCATGGCAAGCAGG
GTGGCCTTGGACTTTGATTTAGGGGATCGTGCTTTGGCCTGGAAAATAAGCACTGGCCTGCATGCCTAGAACCTGAGTGAAGGCAGTCAA
CATCCTAGTATGAATCAGACCTAGCAGAAATGTAAATTATTTCAAGTACTTCAGGGTTTAGTTTTCTTAGTGACACCCTGGACCCTGGAT
GCTGCTTTCTAAAGTGCACCTGATCCATGCAGTTTTATGTCTTCATATAACTGGTATCTTGTGAGTTTGCAAGCAATGGGATGAGCAAGA
AAAAAAGGACGCATGGAGGAGAAAAATTTGAACGAGGCTAGTGCAATGTTTTGCTGATAGATTACATTGTTAGGGAGCTGGTGATTTTTT
GCCATGGTCGTATCGTGGACAGCTTTTCCGTGGAAATTCAAGGCATCTGTATTAGGCAAATGTGAGTGCCCTTGATCTTGTATTGATCAG
TGCCAATGTACTGGGAAAGCAGGTACCCCAGTGAAACTGGTCTGTGCTTGGTTTAACAGCTCCAACAATTTCAGATCCATGGGGCTGCTT
GACCATAGACCCTGTTTACTCCATGCCTGTTCAAAAGTCATTTTGACTTCTAGCTTTGTTTCACTTTCTTCTTTCAATACTTCTGTTTCC
TCGTCCTTTTCCTTCATATTCCATGGCTATTTCTTTCCTACTTTACAGTTTCCCCCAGACCCAGATTTTTTCACACCTCTGCATCATAGA
CAACTGAGTAGCTCCCTTGGCCCCTCCTCCATCCTCTCACACCCTGTGCTCCGTTCCTCAGCCGTTTGGACAGGGAGCTCCGCTGTCACC
AAGGAGCCCATGTGAGACACACTGCTGTGACTGCCTCTTGTTAATGTCAGCATCACCTCATCACTTAAGCAAAAAGGAAAATCCATAAAA
GAGATGGAAAATACGTCTCTTTTTATTTTATTTTAAGAAGATTGGGCGGGGTGGGGGGGGGGTTCTTATTCTAGGCCTTCTCAATTTCTC
ATAGATTTTACCTTAAACTAATTAAGGCCATTCTCTTGATAAATTTGTACATCAGACCGGGTCACCAGCTATGATGCAGAACGCCAGATT
TTTGAATCTCAAGTAACTTTCTGTGGTGCTGGACAAATTGACTTAATTCTGTGCAGGCAAACACTTTGAATCATAAGGATTTTTATTGCC
GCTCCATTCTTACTACTATTCATGATTCAAACATCTACCCCTGTTCTGAATCAGGATGTTGACACTTCTTGGTTATTTTCAGATGAACAG
TAACTGCTACACTCTTGAAAGCACTTAAAAGTGCAAGCATGTCCTAAATAGCCATTTAACCTGGTAAAACATAGGCTTTTCTGTTTAATT
AAGTATTAGACCAGTCTGTAGATATAATCTGAAAAGATTGTAGGCAGTAATGAAGACAGTTGGGGAAAGGAGAAGGCCCTTTAAAGACAT
GAAACCTTACACGCTCTTGGGATATTTTTAAGCATAATAAGCTCATTGGATTCAGGTATTTTTCCCTTTGCATTTTTAAAAATACGTATT
TCTAATTTGTTTGCATATTTAATTTTGTCAAAGCTGAGAAATGCTCATGAGTTGAATTTATAAATGTCATTTGCAACCAAATGAAGTATT
TATTTTTAAAAAGAGAGTGAAGGAACCAACACTGATTTGTACATAATAAAAATGTGTGTATTATATATATATATTTTTTCCTCCTTGACA
GTACTTGGTCACAATATCAAGTGTATTTTTGTACATAATATATATTGATTAGAAAAACGTCAATTGTCTATTCAAAAAATTCTATCTCTG
TGATAGATTATATTTATCCTAATCTGTTGATACCTCTGTTAATTTGTTTTAAGAGAATTATATTTTTTGGAATTTACAGAGAATTGCATT

>In-frame_ENST00000262584_ENST00000334528_TCGA-EE-A29Q-06A_RPL8_chr8_146015154_-_FMN1_chr15_33096533_length(amino acids)=257AA_start in transcript=233_stop in transcript=1006
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYC
GKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL

--------------------------------------------------------------
>In-frame_ENST00000262584_ENST00000561249_TCGA-EE-A29Q-06A_RPL8_chr8_146015154_-_FMN1_chr15_33096533_length(transcript)=1532nt_BP=1041nt
ACCAGGACACCTTCAGCCGCGTCTCCTGGTGCGCCTGCGCGGGGGCCCTGGAGGAGGAGAAGTAGGCGGGGCCGGCGGCCGCTGGTGACT
ACAAGCCCCGGCGTGCACCGCGCTAGGCTGGCCGTGGCGCGCCCGGAAGGTGTCGCGGCCCTGGGCCCCGCCCCGGAAGATAAGGCCGCT
CGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCG
GGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGG
GCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGGTTTAAGAAGCGGA
CGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATTGGCAATGTGCTCC
CTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGGGCATCAGGGAACT
ATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATCTCCTCAGCCAACA
GAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAATATAAGGCAAAGA
GGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCACATCGGCAAGCCCT
CCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGAACCAAGACTGTGC
AGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCCCAAAAAAGAGCATAAGATGGAAGAAAGTCACTTGGAGA
ATGCACAGAAAAGTTTTGAAACAACAGTACGATATTTTGGGATGAAGCCAAAGTCTGGTGAGAAGGAGATCACACCCAGCTACGTGTTTA
TGGTGTGGTATGAGTTCTGCAGTGACTTCAAGACAATTTGGAAACGGGAGAGTAAAAACATATCTAAAGAAAGATTGAAAATGGCTCAGG
AATCAGTCAGCAAGTTGACTTCAGAGAAGAAAGTGGAGACAAAGAAAATCAATCCCACTGCTAGCCTGAAAGAAAGACTGCGTCAGAAGG
AAGCCAGTGTGACCACTAACTAAGATGAAGACACATGGAAATGATGGCACTGGAGGTGGAGGACCTTGCACGCATACTCTTTGTGACCAC
AGGGTTGCAGGACGTTCTTGAAAGATGTGTCACTAAATGTTTGTTTTTGCTCATCTCTTTCTGAGGTCATCTGCAGAGAGTGCCCCATGC

>In-frame_ENST00000262584_ENST00000561249_TCGA-EE-A29Q-06A_RPL8_chr8_146015154_-_FMN1_chr15_33096533_length(amino acids)=257AA_start in transcript=233_stop in transcript=1006
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYC
GKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL

--------------------------------------------------------------
>In-frame_ENST00000262584_ENST00000559047_TCGA-EE-A29Q-06A_RPL8_chr8_146015154_-_FMN1_chr15_33096533_length(transcript)=1373nt_BP=1041nt
ACCAGGACACCTTCAGCCGCGTCTCCTGGTGCGCCTGCGCGGGGGCCCTGGAGGAGGAGAAGTAGGCGGGGCCGGCGGCCGCTGGTGACT
ACAAGCCCCGGCGTGCACCGCGCTAGGCTGGCCGTGGCGCGCCCGGAAGGTGTCGCGGCCCTGGGCCCCGCCCCGGAAGATAAGGCCGCT
CGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCG
GGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGG
GCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGGTTTAAGAAGCGGA
CGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATTGGCAATGTGCTCC
CTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGGGCATCAGGGAACT
ATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATCTCCTCAGCCAACA
GAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAATATAAGGCAAAGA
GGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCACATCGGCAAGCCCT
CCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGAACCAAGACTGTGC
AGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCCCAAAAAAGAGCATAAGATGGAAGAAAGTCACTTGGAGA
ATGCACAGAAAAGTTTTGAAACAACAGTACGATATTTTGGGATGAAGCCAAAGTCTGGTGAGAAGGAGATCACACCCAGCTACGTGTTTA
TGGTGTGGTATGAGTTCTGCAGTGACTTCAAGACAATTTGGAAACGGGAGAGTAAAAACATATCTAAAGAAAGATTGAAAATGGCTCAGG
AATCAGTCAGCAAGTTGACTTCAGAGAAGAAAGTGGAGACAAAGAAAATCAATCCCACTGCTAGCCTGAAAGAAAGACTGCGTCAGAAGG

>In-frame_ENST00000262584_ENST00000559047_TCGA-EE-A29Q-06A_RPL8_chr8_146015154_-_FMN1_chr15_33096533_length(amino acids)=257AA_start in transcript=233_stop in transcript=1006
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYC
GKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RPL8-FMN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RPL8-FMN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RPL8-FMN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource