FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATG5-AK9 (FusionGDB2 ID:7668)

Fusion Gene Summary for ATG5-AK9

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG5-AK9
Fusion gene ID: 7668
HgeneTgene
Gene symbol

ATG5

AK9

Gene ID

9474

221264

Gene nameautophagy related 5adenylate kinase 9
SynonymsAPG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5AK 9|AKD1|AKD2|C6orf199|C6orf224|dJ70A9.1
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptionautophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific proteinadenylate kinase 9adenylate kinase domain containing 1adenylate kinase domain containing 2
Modification date2020031320200313
UniProtAcc

Q9H1Y0

Q5TCS8

Ensembl transtripts involved in fusion geneENST00000343245, ENST00000369070, 
ENST00000369076, ENST00000360666, 
ENST00000475645, 		ENST00000424296, 
ENST00000341338, ENST00000368948, 
ENST00000285397, ENST00000355283, 
Fusion gene scores* DoF score25 X 16 X 9=36003 X 3 X 2=18
# samples 293
** MAII scorelog2(29/3600*10)=-3.6338721012021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATG5 [Title/Abstract] AND AK9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG5(106696025)-AK9(109980616), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAK9

GO:0006174

dADP phosphorylation

23416111

TgeneAK9

GO:0006186

dGDP phosphorylation

23416111

TgeneAK9

GO:0006756

AMP phosphorylation

23416111

TgeneAK9

GO:0006757

ATP generation from ADP

23416111

TgeneAK9

GO:0061508

CDP phosphorylation

23416111

TgeneAK9

GO:0061565

dAMP phosphorylation

23416111

TgeneAK9

GO:0061566

CMP phosphorylation

23416111

TgeneAK9

GO:0061567

dCMP phosphorylation

23416111

TgeneAK9

GO:0061568

GDP phosphorylation

23416111

TgeneAK9

GO:0061569

UDP phosphorylation

23416111

TgeneAK9

GO:0061570

dCDP phosphorylation

23416111

TgeneAK9

GO:0061571

TDP phosphorylation

23416111


check buttonFusion gene breakpoints across ATG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AK9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A6S9-01AATG5chr6

106696025

-AK9chr6

109980616

-
ChimerDB4BRCATCGA-EW-A6S9-01AATG5chr6

106696025

-AK9chr6

109980616

-


Top

Fusion Gene ORF analysis for ATG5-AK9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000343245ENST00000424296ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000343245ENST00000341338ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000343245ENST00000368948ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000343245ENST00000285397ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-intronENST00000343245ENST00000355283ATG5chr6

106696025

-AK9chr6

109980616

-
Frame-shiftENST00000369070ENST00000424296ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000369070ENST00000341338ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000369070ENST00000368948ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000369070ENST00000285397ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-intronENST00000369070ENST00000355283ATG5chr6

106696025

-AK9chr6

109980616

-
Frame-shiftENST00000369076ENST00000424296ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000369076ENST00000341338ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000369076ENST00000368948ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000369076ENST00000285397ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-intronENST00000369076ENST00000355283ATG5chr6

106696025

-AK9chr6

109980616

-
Frame-shiftENST00000360666ENST00000424296ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000360666ENST00000341338ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000360666ENST00000368948ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-5UTRENST00000360666ENST00000285397ATG5chr6

106696025

-AK9chr6

109980616

-
5CDS-intronENST00000360666ENST00000355283ATG5chr6

106696025

-AK9chr6

109980616

-
intron-3CDSENST00000475645ENST00000424296ATG5chr6

106696025

-AK9chr6

109980616

-
intron-5UTRENST00000475645ENST00000341338ATG5chr6

106696025

-AK9chr6

109980616

-
intron-5UTRENST00000475645ENST00000368948ATG5chr6

106696025

-AK9chr6

109980616

-
intron-5UTRENST00000475645ENST00000285397ATG5chr6

106696025

-AK9chr6

109980616

-
intron-intronENST00000475645ENST00000355283ATG5chr6

106696025

-AK9chr6

109980616

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343245ATG5chr6106696025-ENST00000424296AK9chr6109980616-657877320060641954

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343245ENST00000424296ATG5chr6106696025-AK9chr6109980616-0.0011117480.9988883

Top

Fusion Genomic Features for ATG5-AK9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ATG5-AK9


check button Go to

FGviewer for the breakpoints of chr6:106696025-chr6:109980616

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG5

Q9H1Y0

AK9

Q5TCS8

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.FUNCTION: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. {ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAK9chr6:106696025chr6:109980616ENST00000285397512443_485148.0422.0Coiled coilOntology_term=ECO:0000255
TgeneAK9chr6:106696025chr6:109980616ENST00000285397512676_711148.0422.0Coiled coilOntology_term=ECO:0000255
TgeneAK9chr6:106696025chr6:109980616ENST0000035528305443_4850337.0Coiled coilOntology_term=ECO:0000255
TgeneAK9chr6:106696025chr6:109980616ENST0000035528305676_7110337.0Coiled coilOntology_term=ECO:0000255
TgeneAK9chr6:106696025chr6:109980616ENST00000424296541443_485148.01912.0Coiled coilOntology_term=ECO:0000255
TgeneAK9chr6:106696025chr6:109980616ENST00000424296541676_711148.01912.0Coiled coilOntology_term=ECO:0000255
TgeneAK9chr6:106696025chr6:109980616ENST00000285397512198_275148.0422.0Compositional biasNote=Glu-rich
TgeneAK9chr6:106696025chr6:109980616ENST0000035528305198_2750337.0Compositional biasNote=Glu-rich
TgeneAK9chr6:106696025chr6:109980616ENST00000424296541198_275148.01912.0Compositional biasNote=Glu-rich
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121001_1006148.0422.0Nucleotide bindingATP 2
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121050_1052148.0422.0Nucleotide bindingAMP 2
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121079_1082148.0422.0Nucleotide bindingAMP 2
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121421_1426148.0422.0Nucleotide bindingATP 3
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121470_1472148.0422.0Nucleotide bindingAMP 3
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121499_1502148.0422.0Nucleotide bindingAMP 3
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051001_10060337.0Nucleotide bindingATP 2
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051050_10520337.0Nucleotide bindingAMP 2
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051079_10820337.0Nucleotide bindingAMP 2
TgeneAK9chr6:106696025chr6:109980616ENST0000035528305116_1190337.0Nucleotide bindingAMP 1
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051421_14260337.0Nucleotide bindingATP 3
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051470_14720337.0Nucleotide bindingAMP 3
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051499_15020337.0Nucleotide bindingAMP 3
TgeneAK9chr6:106696025chr6:109980616ENST000003552830540_450337.0Nucleotide bindingATP 1
TgeneAK9chr6:106696025chr6:109980616ENST000003552830587_890337.0Nucleotide bindingAMP 1
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411001_1006148.01912.0Nucleotide bindingATP 2
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411050_1052148.01912.0Nucleotide bindingAMP 2
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411079_1082148.01912.0Nucleotide bindingAMP 2
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411421_1426148.01912.0Nucleotide bindingATP 3
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411470_1472148.01912.0Nucleotide bindingAMP 3
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411499_1502148.01912.0Nucleotide bindingAMP 3
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121021_1052148.0422.0RegionNMP 2
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121124_1144148.0422.0RegionLID 2
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121412_1601148.0422.0RegionAdenylate kinase 3
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121441_1472148.0422.0RegionNMPbind 3
TgeneAK9chr6:106696025chr6:109980616ENST000002853975121536_1550148.0422.0RegionLID 3
TgeneAK9chr6:106696025chr6:109980616ENST00000285397512160_205148.0422.0RegionLID 1
TgeneAK9chr6:106696025chr6:109980616ENST00000285397512992_1203148.0422.0RegionAdenylate kinase 2
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051021_10520337.0RegionNMP 2
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051124_11440337.0RegionLID 2
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051412_16010337.0RegionAdenylate kinase 3
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051441_14720337.0RegionNMPbind 3
TgeneAK9chr6:106696025chr6:109980616ENST00000355283051536_15500337.0RegionLID 3
TgeneAK9chr6:106696025chr6:109980616ENST0000035528305160_2050337.0RegionLID 1
TgeneAK9chr6:106696025chr6:109980616ENST000003552830531_2850337.0RegionAdenylate kinase 1
TgeneAK9chr6:106696025chr6:109980616ENST000003552830560_890337.0RegionNMP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000035528305992_12030337.0RegionAdenylate kinase 2
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411021_1052148.01912.0RegionNMP 2
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411124_1144148.01912.0RegionLID 2
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411412_1601148.01912.0RegionAdenylate kinase 3
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411441_1472148.01912.0RegionNMPbind 3
TgeneAK9chr6:106696025chr6:109980616ENST000004242965411536_1550148.01912.0RegionLID 3
TgeneAK9chr6:106696025chr6:109980616ENST00000424296541160_205148.01912.0RegionLID 1
TgeneAK9chr6:106696025chr6:109980616ENST00000424296541992_1203148.01912.0RegionAdenylate kinase 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAK9chr6:106696025chr6:109980616ENST00000285397512116_119148.0422.0Nucleotide bindingAMP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000028539751240_45148.0422.0Nucleotide bindingATP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000028539751287_89148.0422.0Nucleotide bindingAMP 1
TgeneAK9chr6:106696025chr6:109980616ENST00000424296541116_119148.01912.0Nucleotide bindingAMP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000042429654140_45148.01912.0Nucleotide bindingATP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000042429654187_89148.01912.0Nucleotide bindingAMP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000028539751231_285148.0422.0RegionAdenylate kinase 1
TgeneAK9chr6:106696025chr6:109980616ENST0000028539751260_89148.0422.0RegionNMP 1
TgeneAK9chr6:106696025chr6:109980616ENST0000042429654131_285148.01912.0RegionAdenylate kinase 1
TgeneAK9chr6:106696025chr6:109980616ENST0000042429654160_89148.01912.0RegionNMP 1


Top

Fusion Gene Sequence for ATG5-AK9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000343245_ENST00000424296_TCGA-EW-A6S9-01A_ATG5_chr6_106696025_-_AK9_chr6_109980616_length(transcript)=6578nt_BP=773nt
GCCCGCCCGGCCGCGATGGCGGGTGAAGGTGGTTCCTCCGGGCAAGGTGGAGTTGGCGAGACGCCGGCCCGGAGCCCTGGGGCCGGTTGG
CGGGTGTGGCCTGCGGGGTCCCTCTTGGGGTACATGTCTGTTGCTTACTAAGTTTGGCTTTGGTTGAAATAAGAATTTAGCCTGTATGTA
CTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAATTCCAACTTGTTTCACGCTATATC
AGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACTGACAAAGTGAAAA
AGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATATGAAGGCACACCACTGAAATGGCATTATCCAATTG
GTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGC
ACTGTCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATG
AAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGACAGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGG
AATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGTGTCCTGACTATGATTTGTGCCAGAGAATTTCTGGGC
AAAGACAGCACAATAATACGGGATACATATACAGTAGAGACCAGTGGGATCCTGAAGTCATTGAGAATCATAGGAAAAAGAAGAAAGAAG
CCCAAAAGGACGGAAAAGGAGAAGAGGAAGAAGAGGAAGAAGAGCAAGAAGAAGAAGAGGCATTTATTGCCGAAATGCAGATGGTGGCTG
AAATTCTTCATCATCTAGTTCAGAGGCCTGAAGATTATTTGGAAAATGTTGAAAACATTGTTAAGCTTTATAAGGAAACAATTCTCCAAA
CTTTAGAAGAAGTAATGGCTGAACACAATCCCCAGTATCTCATTGAGCTAAATGGAAATAAACCAGCAGAGGAGCTCTTTATGATTGTTA
TGGATCGACTTAAATATCTGAACCTAAAAAGAGCAGCTATTCTAACCAAACTTCAGGGTGCAGAGGAAGAAATTAATGACACAATGGAAA
ATGATGAGCTATTTCGTACTCTTGCATCTTATAAACTTATTGCACCAAGATACAGATGGCAAAGAAGTAAATGGGGACGTACATGTCCTG
TGAATTTAAAAGATGGTAACATTTATTCAGGATTACCAGATTATTCTGTGAGTTTTCTAGGTAAAATCTACTGTCTTTCATCAGAAGAAG
CATTAAAACCATTTTTGTTGAACCCACGTCCCTATCTGCTTCCACCTATGCCAGGACCACCATGTAAAGTATTCATACTTGGACCTCAAT
ATTCAGGGAAAACAACACTTTGCAATATGCTTGCAGAAAATTACAAAGGAAAGGTAGTCGACTATGCCCAACTTGTTCAGCCACGTTTTG
ATAAAGCCCGTGAAACATTAGTAGAAAATACCATAGCTGAGGCCACTGCAGCAGCAATTAAAGTTGTGAAAGAAAAGCTTCTCAGGGAAC
TGCAAGCTAGAAAACAAGCTGAAACAGCTTTAAGAGAATTTCAAAGGCAATATGAAAAAATGGAGTTTGGAGTATTCCCAATGGAGGCAA
CACACTCATCAATTGATGAAGAAGGGTACATTCAAGGCTCCCAAAGGGACAGAGGCAGCTCTTTAGTGGACACCGAAGAAGCCAAAACAA
AGTCAGAAAATGTCCTCCATGATCAAGCTGCTAAAGTTGATAAAGATGATGGAAAAGAAACTGGTGAAACATTCACATTTAAAAGGCATT
CTCAAGATGCTAGTCAAGATGTAAAGTTGTATTCAGATACAGCCCCAACAGAAGACTTGATAGAAGAGGTAACTGCAGATCATCCAGAGG
TTGTGACCATGATTGAAGAGACTATAAAAATGTCACAGGATATAAACTTTGAACAGCCATATGAAAAACATGCTGAAATCTTACAGGAAG
TCCTTGGAGAGGTAATGGAAGAAAACAAGGATAGGTTTCCTGGTGCCCCAAAATATGGAGGCTGGATTGTGGACAACTGCCCTATTGTAA
AAGAATTGTGGATGGCCTTAATCAAGAAAGGAATTATACCTGATTTGGTCATCTATTTATCAGATACAGAAAACAATGGAAAATGTTTAT
TTAATAGAATATATTTACAGAAGAAATCTGAAATTGACTCTAAGATTTTAGAAAGATTATTAGAAGAACTACAAAAGAAAAAAAAAGAAG
AAGAAGAAGCAAGAAAAGCCACAGAAGAGGAATTGAGACTCGAAGAAGAAAATCGAAGGCTACTGGAACTTATGAAAGTGAAGGCAAAAG
AAGCTGAAGAGACTGATAATGAGGATGAAGAGGAGATTGAAGGTGATGAGTTGGAAGTTCACGAAGAGCCTGAGGCATCTCACGATACCC
GAGGGTCATGGTTACCTGAGGAGTTTGAAGCATCTGAGGTCCCTGAAACTGAGCCTGAAGCAGTATCTGAGCCTATCGAGGAAACTACAG
TGGAAACAGAAATCCCAAAAGGATCCAAAGAGGGCCTGGAAATTGAAAAATTATCTGAAACAGTTGTACTACCTGAGTTTCCAGAAGACT
CTTATCCTGATGTTCCCGAAATGGAGCCATTTAAAGAGAAGATTGGTTCTTTCATCATCCTCTGGAAACAGCTAGAAGCAACAATTAGTG
AGGCTTACATTAAAATTTTAAACTTGGAGATTGCTGACAGAACTCCACAGGAATTACTTCAAAAAGTAGTTGAGACTATGGAAAAACCAT
TTCAATATACTGCATGGGAGTTAACTGGGGAAGATTATGAGGAAGAAACAGAAGACTACCAGACTGAAGCAGAGGTTGATGAGGAGCTAG
AGGAAGAGGAAGAGGAAGAGGGTGAAGATAAAATGAAGGAGAGAAAGAGGCATTTGGGAGACACAAAACACTTTTGTCCGGTGGTCCTCA
AAGAAAACTTCATCCTGCAACCAGGAAACACAGAAGAAGCAGCCAAGTATCGAGAAAAGATCTACTACTTTTCAAGTGCTGAGGCTAAAG
AAAAGTTTTTGGAGCATCCTGAGGATTATGTGGCTCATGAAGAACCATTGAAGGCTCCTCCATTAAGAATATGCCTTGTCGGCCCCCAGG
GCTCTGGCAAAACTATGTGTGGAAGACAGTTGGCAGAAAAATTAAACATTTTTCACATTCAGTTTGAAGAAGTTCTTCAAGAAAAACTAC
TACTCAAAACTGAAAAGAAAGTGGGACCTGAATTTGAGGAAGATTCTGAGAACGAGCAAGCTGCCAAACAAGAACTTGAAGAGCTTGCAA
TTCAGGCCAATGTCAAAGTTGAGGAAGAAAATACAAAAAAGCAGCTTCCAGAAGTACAACTTACAGAAGAAGAAGAAGTAATCAAATCAA
GTCTAATGGAAAATGAGCCCTTGCCTCCTGAAATTCTTGAAGTAATTCTTTCTGAGTGGTGGCTTAAGGAACCAATACGTTCCACAGGTT
TTATATTAGATGGTTTCCCACGATATCCAGAAGAGGCCCAGTTTTTGGGAGATCGTGGATTTTTCCCAGATGCAGCTGTTTTTATACAAG
TTGATGATCAAGATATTTTTGATCGCCTCCTTCCTGCCCAAATTGAAAAGTGGAAACTAAAACAAAAGAAGAAATTAGAAAGGAAGAAAC
TGATCAAAGACATGAAGGCAAAAATCAGGGTTGATACGATTGCTAAAAGAAGGGCTGAACTTATATTAGAGAGAGATAAAAAAAGGAGGG
AGAATGTTGTTAGAGATGATGAAGAGATTAGTGAGGAAGAACTTGAAGAAGACAATGATGATATTGAAAACATCCTTGAAGATGAGTTTC
CAAAAGATGAGGAAGAGATGAGTGGCGAGGAAGATGAAGAACAGGAAACTGATGCAATTGAGCGCCTGAGAGGTGAACTAGGAGAAAAAT
TTGAAGCAGATACACATAATTTACAAATAATACAGGATGAACTTGAGAGGTATTTGATACCAATAATTTCCATTAATGGAGCTCGGAGAA
ATCACATTGTACAATATACATTGAATATGAAACTGAAACCACTGGTGGAAAATCGTGCAAGCATTTTTGAGAAATGTCATCCAATACCAG
CACCCCTTGCCCAGAAAATGCTCACCTTTACCTACAAGTATATAAGCTCATTCGGCTATTGGGACCCTGTAAAGCTAAGTGAAGGAGAGA
CAATCAAGCCAGTTGAAAATGCAGAGAATCCAATTTATCCTGTAATCCATCGTCAGTATATTTATTTTTTATCTAGTAAAGAAACAAAAG
AAAAATTTATGAAGAACCCAATCAAATATATCCGCCAACCCAAACCTAAGCCTACTGTGCCCATTAGGATTATAATTGTGGGGCCTCCAA
AATCTGGGAAAACTACAGTTGCCAAAAAAATTACAAGTGAATATGGGTTAAAGCATTTATCAATAGGAGGAGCTTTGCGTTATGTACTAA
ACAATCACCCGGAAACAGAGCTGGCACTTATGTTAAATTGGCATCTTCATAAAGGAATGACAGCACCTGATGAACTGGCTATTCAAGCCT
TAGAACTTTCTCTGATGGAAAGTGTGTGCAATACTGCAGGTGTTGTCATCGATGGATATCCTGTAACTAAACATCAAATGAATCTCTTGG
AAGCTAGGTCAATCATTCCCATGGTCATCTTTGAATTGAGTGTGCCTTCCAAGGAGATTTTCAAAAGATTGCTCCTAGAAAAAGAAAATG
AACAAAGATTGCCTTATCCATTGCACAATAGTGCACAAATTGTAGCTGTCAATAATGTAAAGTATCGCAAAAATATTGGTGAGATTAGGC
AATATTATCAAGAACAGCATCAGAACTGGTATGTGATTGATGGATTTCACAGCAAATGGTGGGTATGGAATGAAGTCATTAAGAATGTTC
AAATGGTGAATAAATACATGCAGACATACCTGGAAAGAATAAAAGCAGGAAAAGCTGCCTGCATTGACAAGTTATGTATCACACCTCAAG
AGCTGCTTTCTCGCCTGGGAGAATTTGAACAGTTCTGCCCTGTCAGCCTGGCAGAATCCCAGGAATTATTTGATTGCTCTGCAACTGACT
CCTTGGAATTTGCAGCAGAGTTCAGGGGGCACTACTATAAAATGAGTTCTCAGGAAAAACTGAATAAATTCTTGGAGAACCCAGAATTGT
ACGTGCCTCCCTTAGCACCTCATCCACTCCCATCTGCTGACATGATCCCCAAAAGACTGACACTGTCAGAGCTGAAGAGTCGATTCCCTA
AGTGTGCGGAGCTCCAGGGCTACTGTCCAGTGACCTATAAGGATGGAAACCAAAGATATGAAGCTCTAGTACCTGGTAGCATTAACTATG
CTTTAGAATATCATAATCGTATATATATTTGTGAGAACAAAGAAAAACTCCAGAAATTTTTGAGGTCGCCACTGAAATACTGGGAACAGA
AGCTTCCACACAAGCTTCCCCCATTAAGGGAACCGATACTTCTTACTAGTCTTCCTTTGCCTGGATATCTGGAACAGGGTATTGCAACTT
CTCTAATTAAAGCAATGAATGCAGCGGGATGCTTAAAGCCCAAGTTCCCCTTTTTAAGTATAAGGAGATCTGCACTGCTATATATAGCAC
TTCATCTCAAAGCATTTAATCCCAAAGGTTCCGAATACACAAGAAAAAAGTATAAGAAGAAGATGGAGCAGTTTATGGAGAGTTGTGAAC
TCATAACATACTTGGGTGCCAAGATGACCAGAAAATACAAGGAACCTCAGTTCAGAGCCATTGACTTTGATCATAAGTTAAAGACCTTTC
TCTCTCTCAGAAATATAGACCCAATTAATGGGTAGTTTACTTAGGTGATAGCAGCCTGAATCTCAAGAGTTATCTGAAAGTGATAGAGGG
AAACTGAGAGAAGTAGATTGAAAATCTGGGCCTCTTGGAAGTACTTTTGCCTCCTGAGCAAGGTACCATGGCTGCCAGACTTCAGGTGAA
CTCAAAGGTCTGCCAGCCAGGAAGGAGCACTCTTATGGAAACAAGTTTTAATACAATTTTAAAATGTATTGCTCTTTGCCTGAACTTTGA
TGCTTTAACAAAATAAACATTCTATTTATAATTCCATATAGAAAAGTTAAGTGACTTATTTAATAAATGTATTATTTTCCTTTTTAACAT
TTTCAGTAGAAAAGTCAGTCTCTGTTAAAATTACTCATTAAATGTTAGAAAGCTTTAAGACATTTAACATTGTTATAAATGAAACCAAAA
TATGGGTTATACATTTTACATACAAAACTGTTTGTGAACTTTGTGAACATAAGATACTATCATTTTCCCAATAAAATAAATGGATTTTGC

>In-frame_ENST00000343245_ENST00000424296_TCGA-EW-A6S9-01A_ATG5_chr6_106696025_-_AK9_chr6_109980616_length(amino acids)=1954AA_start in transcript=200_stop in transcript=6064
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLL
ASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWAINRKLMEYPAEEN
GFRYIPFRIYQCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEVIENHRKKKKEAQKDGKGEEEEEEEEQEEEEAFIAEMQMVAEILHHLV
QRPEDYLENVENIVKLYKETILQTLEEVMAEHNPQYLIELNGNKPAEELFMIVMDRLKYLNLKRAAILTKLQGAEEEINDTMENDELFRT
LASYKLIAPRYRWQRSKWGRTCPVNLKDGNIYSGLPDYSVSFLGKIYCLSSEEALKPFLLNPRPYLLPPMPGPPCKVFILGPQYSGKTTL
CNMLAENYKGKVVDYAQLVQPRFDKARETLVENTIAEATAAAIKVVKEKLLRELQARKQAETALREFQRQYEKMEFGVFPMEATHSSIDE
EGYIQGSQRDRGSSLVDTEEAKTKSENVLHDQAAKVDKDDGKETGETFTFKRHSQDASQDVKLYSDTAPTEDLIEEVTADHPEVVTMIEE
TIKMSQDINFEQPYEKHAEILQEVLGEVMEENKDRFPGAPKYGGWIVDNCPIVKELWMALIKKGIIPDLVIYLSDTENNGKCLFNRIYLQ
KKSEIDSKILERLLEELQKKKKEEEEARKATEEELRLEEENRRLLELMKVKAKEAEETDNEDEEEIEGDELEVHEEPEASHDTRGSWLPE
EFEASEVPETEPEAVSEPIEETTVETEIPKGSKEGLEIEKLSETVVLPEFPEDSYPDVPEMEPFKEKIGSFIILWKQLEATISEAYIKIL
NLEIADRTPQELLQKVVETMEKPFQYTAWELTGEDYEEETEDYQTEAEVDEELEEEEEEEGEDKMKERKRHLGDTKHFCPVVLKENFILQ
PGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEEPLKAPPLRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKK
VGPEFEEDSENEQAAKQELEELAIQANVKVEEENTKKQLPEVQLTEEEEVIKSSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFP
RYPEEAQFLGDRGFFPDAAVFIQVDDQDIFDRLLPAQIEKWKLKQKKKLERKKLIKDMKAKIRVDTIAKRRAELILERDKKRRENVVRDD
EEISEEELEEDNDDIENILEDEFPKDEEEMSGEEDEEQETDAIERLRGELGEKFEADTHNLQIIQDELERYLIPIISINGARRNHIVQYT
LNMKLKPLVENRASIFEKCHPIPAPLAQKMLTFTYKYISSFGYWDPVKLSEGETIKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNP
IKYIRQPKPKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNWHLHKGMTAPDELAIQALELSLME
SVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPYPLHNSAQIVAVNNVKYRKNIGEIRQYYQEQH
QNWYVIDGFHSKWWVWNEVIKNVQMVNKYMQTYLERIKAGKAACIDKLCITPQELLSRLGEFEQFCPVSLAESQELFDCSATDSLEFAAE
FRGHYYKMSSQEKLNKFLENPELYVPPLAPHPLPSADMIPKRLTLSELKSRFPKCAELQGYCPVTYKDGNQRYEALVPGSINYALEYHNR
IYICENKEKLQKFLRSPLKYWEQKLPHKLPPLREPILLTSLPLPGYLEQGIATSLIKAMNAAGCLKPKFPFLSIRRSALLYIALHLKAFN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATG5-AK9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATG5-AK9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ATG5-AK9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATG5C0002871Anemia1CTD_human
HgeneATG5C0019193Hepatitis, Toxic1CTD_human
HgeneATG5C0019209Hepatomegaly1CTD_human
HgeneATG5C0023380Lethargy1CTD_human
HgeneATG5C0024312Lymphopenia1CTD_human
HgeneATG5C0027540Necrosis1CTD_human
HgeneATG5C0860207Drug-Induced Liver Disease1CTD_human
HgeneATG5C0919267ovarian neoplasm1CTD_human
HgeneATG5C1140680Malignant neoplasm of ovary1CTD_human
HgeneATG5C1262477Weight decreased1CTD_human
HgeneATG5C1262760Hepatitis, Drug-Induced1CTD_human
HgeneATG5C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneATG5C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneATG5C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneATG5C4539808SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 251UNIPROT
TgeneAK9C0751883Congenital Myasthenic Syndromes, Postsynaptic1ORPHANET