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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPN2-RERE (FusionGDB2 ID:76734)

Fusion Gene Summary for RPN2-RERE

check button Fusion gene summary
Fusion gene informationFusion gene name: RPN2-RERE
Fusion gene ID: 76734
HgeneTgene
Gene symbol

RPN2

RERE

Gene ID

6185

473

Gene nameribophorin IIarginine-glutamic acid dipeptide repeats
SynonymsRIBIIR|RPN-II|RPNII|SWP1ARG|ARP|ATN1L|DNB1|NEDBEH
Cytomap

20q11.23

1p36.23

Type of geneprotein-codingprotein-coding
Descriptiondolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2arginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000237530, ENST00000373622, 
ENST00000470352, 		ENST00000337907, 
ENST00000377464, ENST00000400907, 
ENST00000400908, ENST00000476556, 
ENST00000460659, 
Fusion gene scores* DoF score15 X 12 X 8=144018 X 17 X 8=2448
# samples 1724
** MAII scorelog2(17/1440*10)=-3.08246216019197
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2448*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPN2 [Title/Abstract] AND RERE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPN2(35842268)-RERE(8617582), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RPN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RERE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5771-01ARPN2chr20

35842268

+REREchr1

8617582

-


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Fusion Gene ORF analysis for RPN2-RERE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000237530ENST00000337907RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000237530ENST00000377464RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000237530ENST00000400907RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000237530ENST00000400908RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000237530ENST00000476556RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000237530ENST00000460659RPN2chr20

35842268

+REREchr1

8617582

-
In-frameENST00000373622ENST00000337907RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000373622ENST00000377464RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000373622ENST00000400907RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000373622ENST00000400908RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000373622ENST00000476556RPN2chr20

35842268

+REREchr1

8617582

-
5CDS-intronENST00000373622ENST00000460659RPN2chr20

35842268

+REREchr1

8617582

-
intron-3CDSENST00000470352ENST00000337907RPN2chr20

35842268

+REREchr1

8617582

-
intron-intronENST00000470352ENST00000377464RPN2chr20

35842268

+REREchr1

8617582

-
intron-intronENST00000470352ENST00000400907RPN2chr20

35842268

+REREchr1

8617582

-
intron-intronENST00000470352ENST00000400908RPN2chr20

35842268

+REREchr1

8617582

-
intron-intronENST00000470352ENST00000476556RPN2chr20

35842268

+REREchr1

8617582

-
intron-intronENST00000470352ENST00000460659RPN2chr20

35842268

+REREchr1

8617582

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000237530RPN2chr2035842268+ENST00000337907REREchr18617582-8272140320955811790
ENST00000373622RPN2chr2035842268+ENST00000337907REREchr18617582-806111929453701758

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000237530ENST00000337907RPN2chr2035842268+REREchr18617582-0.0022218220.99777824
ENST00000373622ENST00000337907RPN2chr2035842268+REREchr18617582-0.0021216330.99787843

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Fusion Genomic Features for RPN2-RERE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPN2-RERE


check button Go to

FGviewer for the breakpoints of chr20:35842268-chr1:8617582

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneREREchr20:35842268chr1:8617582ENST000003379074241156_1211174.01567.0Coiled coilOntology_term=ECO:0000255
TgeneREREchr20:35842268chr1:8617582ENST000004009083231156_1211174.01567.0Coiled coilOntology_term=ECO:0000255
TgeneREREchr20:35842268chr1:8617582ENST000004765560131156_121101013.0Coiled coilOntology_term=ECO:0000255
TgeneREREchr20:35842268chr1:8617582ENST000003379074241179_1204174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneREREchr20:35842268chr1:8617582ENST000003379074241300_1322174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneREREchr20:35842268chr1:8617582ENST000003379074241425_1445174.01567.0Compositional biasNote=His-rich
TgeneREREchr20:35842268chr1:8617582ENST000003379074241451_1510174.01567.0Compositional biasNote=Pro-rich
TgeneREREchr20:35842268chr1:8617582ENST00000337907424738_1118174.01567.0Compositional biasNote=Pro-rich
TgeneREREchr20:35842268chr1:8617582ENST000004009083231179_1204174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneREREchr20:35842268chr1:8617582ENST000004009083231300_1322174.01567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneREREchr20:35842268chr1:8617582ENST000004009083231425_1445174.01567.0Compositional biasNote=His-rich
TgeneREREchr20:35842268chr1:8617582ENST000004009083231451_1510174.01567.0Compositional biasNote=Pro-rich
TgeneREREchr20:35842268chr1:8617582ENST00000400908323738_1118174.01567.0Compositional biasNote=Pro-rich
TgeneREREchr20:35842268chr1:8617582ENST000004765560131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneREREchr20:35842268chr1:8617582ENST000004765560131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneREREchr20:35842268chr1:8617582ENST000004765560131425_144501013.0Compositional biasNote=His-rich
TgeneREREchr20:35842268chr1:8617582ENST000004765560131451_151001013.0Compositional biasNote=Pro-rich
TgeneREREchr20:35842268chr1:8617582ENST00000476556013738_111801013.0Compositional biasNote=Pro-rich
TgeneREREchr20:35842268chr1:8617582ENST00000337907424284_387174.01567.0DomainELM2
TgeneREREchr20:35842268chr1:8617582ENST00000337907424391_443174.01567.0DomainSANT
TgeneREREchr20:35842268chr1:8617582ENST00000400908323284_387174.01567.0DomainELM2
TgeneREREchr20:35842268chr1:8617582ENST00000400908323391_443174.01567.0DomainSANT
TgeneREREchr20:35842268chr1:8617582ENST00000476556013103_28301013.0DomainBAH
TgeneREREchr20:35842268chr1:8617582ENST00000476556013284_38701013.0DomainELM2
TgeneREREchr20:35842268chr1:8617582ENST00000476556013391_44301013.0DomainSANT
TgeneREREchr20:35842268chr1:8617582ENST00000337907424507_532174.01567.0Zinc fingerNote=GATA-type
TgeneREREchr20:35842268chr1:8617582ENST00000400908323507_532174.01567.0Zinc fingerNote=GATA-type
TgeneREREchr20:35842268chr1:8617582ENST00000476556013507_53201013.0Zinc fingerNote=GATA-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+91723_540364.0632.0Topological domainLumenal
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+917562_571364.0632.0Topological domainCytoplasmic
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+917593_596364.0632.0Topological domainLumenal
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+917618_631364.0632.0Topological domainCytoplasmic
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+81723_540332.0616.0Topological domainLumenal
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+817562_571332.0616.0Topological domainCytoplasmic
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+817593_596332.0616.0Topological domainLumenal
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+817618_631332.0616.0Topological domainCytoplasmic
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+917541_561364.0632.0TransmembraneHelical
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+917572_592364.0632.0TransmembraneHelical
HgeneRPN2chr20:35842268chr1:8617582ENST00000237530+917597_617364.0632.0TransmembraneHelical
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+817541_561332.0616.0TransmembraneHelical
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+817572_592332.0616.0TransmembraneHelical
HgeneRPN2chr20:35842268chr1:8617582ENST00000373622+817597_617332.0616.0TransmembraneHelical
TgeneREREchr20:35842268chr1:8617582ENST00000337907424103_283174.01567.0DomainBAH
TgeneREREchr20:35842268chr1:8617582ENST00000400908323103_283174.01567.0DomainBAH


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Fusion Gene Sequence for RPN2-RERE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000237530_ENST00000337907_TCGA-CH-5771-01A_RPN2_chr20_35842268_+_RERE_chr1_8617582_length(transcript)=8272nt_BP=1403nt
GCGTCCCGGTAGCTCCCGGAATAGGAGCGTTGCGAGACGGTCGGTTCCAAGTGGGCCTGGGCGCGGGGGAGAGGCGGGTCTGTCCTCGGG
AACTGCAAGGCCCTGTGAGCGGGAGGACTGGGATCCCGGCCGCGGCTGCTGGAAGCGTCGAAGCTCAGCGGGGCCGCGGACACTGACCTG
TGCTTAGAACTCATCCTGGCCCGCAGAGCCTGCCGCGAGTCCCTGGCGTCCCCTGTGGCGGGCTCTTGGAGCCACTTTCCCGAGCGGAAG
TCAGCCCGCGGCTCGGACTCCGGCGGGACCTGCTCGGAGGAATGGCGCCGCCGGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATCA
TAGCCAGCACCTGGGCTCTGACGCCCACTCACTACCTCACCAAGCATGACGTGGAGAGACTAAAAGCCTCGCTGGATCGCCCTTTCACAA
ATTTGGAATCTGCCTTCTACTCCATCGTGGGACTCAGCAGCCTTGGTGCTCAGGTGCCAGATGCAAAGAAAGCATGTACCTACATCAGAT
CTAACCTTGATCCCAGCAATGTGGATTCCCTCTTCTACGCTGCCCAGGCCAGCCAGGCCCTCTCAGGATGTGAGATCTCTATTTCAAATG
AGACCAAAGATCTGCTTCTGGCAGCTGTCAGTGAGGACTCATCTGTTACCCAGATCTACCATGCAGTTGCAGCTCTAAGTGGCTTTGGCC
TTCCCTTGGCATCCCAAGAAGCACTCAGTGCCCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACAGTCCAGGCTCTGCAGA
CAGCATCCCACCTGTCCCAGCAGGCTGACCTGAGGAGCATCGTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTCGGGGGCG
TGTATCTCCAGTTTGAAGAAGGACTGGAAACAACAGCGTTATTTGTGGCTGCCACCTACAAGCTCATGGATCATGTGGGGACTGAGCCAT
CCATTAAGGAGGATCAGGTCATCCAGCTGATGAACGCGATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCCT
CTGCAGCTGCTGTGCTCTCGCATAATCGCTACCACGTGCCAGTTGTGGTTGTGCCTGAGGGCTCTGCTTCCGACACTCATGAACAGGCTA
TCTTGCGGTTGCAAGTCACCAATGTTCTGTCTCAGCCTCTGACTCAGGCCACTGTTAAACTAGAACATGCTAAATCTGTTGCTTCCAGAG
CCACTGTCCTCCAGAAGACATCCTTCACCCCTGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTCAAATTTTCCAGTGGTTATTATG
ACTTCCTTGTCGAAGTTGAAGGTGACAACCGGTATATTGCAAATACCGTAGAGAGTAAGAGGGACCATCTCCTCATGAACGTCAAATGGT
ACTACCGTCAATCTGAGGTTCCAGATTCTGTGTATCAGCATTTGGTTCAGGATCGACATAATGAAAATGACTCTGGAAGAGAACTTGTCA
TTACAGACCCAGTTATCAAGAACCGAGAGCTCTTCATTTCTGATTACGTTGACACTTACCATGCTGCTGCCCTTAGAGGGAAGTGTAACA
TCTCCCATTTTTCTGACATATTTGCTGCTAGAGAGTTTAAAGCCCGAGTGGATTCATTTTTCTACATATTAGGATATAACCCTGAGACAA
GGAGGCTGAACAGTACCCAGGGGGAGATTCGTGTCGGTCCTAGTCATCAGGCCAAACTTCCAGATCTGCAACCATTTCCTTCTCCAGATG
GTGATACAGTGACCCAACATGAGGAACTGGTCTGGATGCCTGGAGTTAACGACTGTGACCTCCTTATGTACTTGAGGGCAGCAAGGAGCA
TGGCGGCATTTGCAGGAATGTGTGATGGAGGCTCTACAGAGGACGGCTGTGTCGCAGCCTCTCGGGATGACACCACTCTGAATGCACTGA
ACACACTGCATGAAAGCGGTTACGATGCTGGCAAAGCCCTGCAGCGCCTGGTGAAGAAGCCTGTGCCCAAGCTCATCGAGAAGTGCTGGA
CCGAGGACGAAGTGAAACGCTTCGTTAAGGGACTCAGGCAGTACGGGAAGAACTTCTTCAGAATTAGAAAGGAGCTGCTTCCCAATAAGG
AAACAGGGGAGCTGATCACCTTCTATTACTATTGGAAGAAGACCCCCGAAGCAGCCAGCTCCCGAGCCCATCGTAGGCACCGCAGGCAGG
CCGTGTTCAGGAGGATTAAGACTCGCACCGCGTCCACACCCGTCAACACACCCTCCAGACCCCCGTCCAGTGAATTCTTGGACCTAAGTT
CAGCCAGTGAAGATGACTTCGACAGTGAGGACAGTGAGCAGGAGCTGAAGGGGTACGCCTGCCGCCACTGCTTCACCACCACCTCCAAAG
ATTGGCACCACGGAGGCCGGGAGAACATCCTGCTTTGCACCGACTGTCGCATCCACTTCAAGAAATACGGTGAGCTCCCGCCCATTGAGA
AGCCCGTGGACCCGCCACCGTTTATGTTCAAACCCGTCAAGGAAGAGGATGATGGGCTCAGTGGGAAGCATAGCATGAGGACACGGCGGA
GTCGGGGCTCGATGTCGACACTACGCAGTGGTCGGAAGAAGCAGCCAGCCAGCCCTGATGGTCGCACCTCACCCATCAATGAAGACATCC
GCTCCAGCGGCCGGAACTCCCCCAGCGCTGCCAGTACCTCCAGCAATGACAGTAAAGCAGAGACAGTGAAGAAGTCGGCCAAGAAGGTGA
AGGAGGAAGCCTCTTCCCCTCTTAAGAGTAACAAACGCCAGCGGGAGAAGGTGGCCTCTGATACGGAGGAGGCTGACAGGACCAGCTCCA
AGAAGACAAAAACGCAGGAGATCAGCAGGCCCAACTCGCCATCTGAAGGTGAGGGAGAGAGTTCAGACAGTCGCAGCGTCAACGATGAGG
GTAGCAGTGACCCCAAAGACATCGACCAGGACAATCGCAGCACGTCCCCGAGCATCCCCAGCCCCCAGGACAATGAGAGTGACTCGGACT
CGTCAGCCCAGCAGCAGATGCTGCAGGCCCAGCCCCCAGCCTTGCAGGCTCCCACTGGGGTCACCCCAGCTCCCTCCTCAGCTCCTCCAG
GGACCCCTCAGCTGCCCACGCCAGGGCCCACGCCCTCTGCCACTGCAGTTCCCCCACAGGGCTCCCCCACGGCCTCCCAGGCCCCTAACC
AGCCACAGGCTCCCACAGCGCCTGTTCCCCACACCCACATCCAACAGGCACCGGCCTTGCACCCCCAGCGGCCGCCCTCACCGCATCCCC
CGCCGCATCCCTCGCCACATCCCCCGCTGCAGCCTCTGACTGGGTCGGCGGGCCAGCCTTCTGCACCCTCTCATGCCCAGCCCCCACTGC
ACGGTCAGGGCCCACCCGGCCCTCACAGCCTGCAGGCTGGGCCCCTGCTGCAGCACCCAGGCCCCCCACAGCCCTTTGGCCTCCCTCCCC
AGGCCTCCCAAGGCCAGGCCCCTCTGGGGACCTCCCCAGCAGCAGCGTACCCTCACACCTCCCTGCAGCTGCCAGCCTCTCAGTCAGCGC
TGCAGTCCCAACAGCCTCCACGGGAGCAGCCCCTGCCACCAGCGCCCTTGGCCATGCCCCACATCAAGCCCCCGCCTACCACTCCCATCC
CCCAGCTGCCGGCGCCACAGGCCCACAAGCACCCTCCCCACCTCTCGGGGCCCTCACCCTTCTCCATGAATGCCAACCTGCCTCCCCCTC
CAGCCCTGAAGCCCCTGAGCTCCCTGTCCACACATCACCCCCCGTCGGCTCACCCCCCACCCCTGCAACTCATGCCTCAGAGCCAGCCAT
TGCCCTCCTCGCCCGCCCAGCCCCCCGGGCTGACCCAGAGCCAGAACCTGCCCCCGCCCCCTGCCTCCCACCCCCCTACAGGCCTCCACC
AGGTGGCCCCCCAACCCCCGTTTGCTCAGCACCCCTTTGTCCCTGGAGGCCCTCCTCCCATCACCCCTCCGACCTGCCCCTCCACCTCTA
CCCCACCGGCGGGACCTGGCACCTCGGCCCAGCCACCCTGCTCTGGTGCGGCGGCTTCAGGAGGCAGCATAGCGGGGGGGTCGTCCTGCC
CACTCCCCACCGTCCAGATCAAGGAGGAGGCTCTGGACGACGCTGAGGAGCCTGAGAGCCCCCCTCCCCCACCAAGGAGCCCGTCCCCGG
AGCCCACTGTGGTGGACACCCCCAGTCACGCCAGCCAGTCAGCTAGGTTCTACAAACACCTGGACCGGGGCTACAACTCGTGTGCCCGGA
CAGACCTGTACTTCATGCCTCTGGCCGGGTCCAAGCTGGCCAAGAAGAGGGAGGAGGCCATTGAGAAGGCCAAGCGCGAGGCTGAGCAGA
AAGCCCGAGAGGAGCGAGAGCGGGAGAAGGAGAAGGAGAAGGAGCGGGAGCGGGAGCGAGAGCGGGAGCGCGAGGCAGAGCGGGCGGCTA
AGGCGTCCAGCTCAGCGCATGAAGGTCGCCTCAGTGACCCACAGCTCAGTGGTCCTGGCCACATGCGGCCATCCTTCGAGCCACCACCAA
CCACCATTGCTGCTGTGCCCCCCTACATCGGGCCCGACACACCTGCCCTTCGGACTCTGAGCGAGTACGCCCGGCCCCACGTCATGTCGC
CCACCAACCGCAACCACCCCTTCTACATGCCCCTTAACCCCACGGACCCCCTGCTGGCCTACCACATGCCTGGCCTCTACAACGTCGACC
CCACCATCCGCGAGCGGGAGCTCCGGGAGCGGGAGATCCGAGAGCGGGAGATCCGAGAGCGGGAGCTGCGGGAGAGGATGAAGCCGGGCT
TCGAGGTGAAGCCCCCAGAGCTGGACCCCCTGCACCCAGCCGCCAACCCCATGGAGCACTTTGCCCGGCACAGCGCCCTCACCATCCCCC
CGACCGCCGGGCCCCACCCTTTTGCTTCTTTCCACCCGGGCCTGAACCCCTTGGAGAGGGAGAGACTGGCCCTGGCGGGCCCCCAGCTGC
GGCCCGAGATGAGCTACCCTGACAGACTGGCAGCCGAGCGTATCCACGCAGAGCGCATGGCATCGCTGACCAGCGATCCCCTGGCCCGAC
TGCAGATGTTCAACGTGACTCCGCACCATCACCAGCACTCTCACATTCACTCCCACCTCCACCTCCACCAGCAGGACCCCCTCCACCAAG
GTTCAGCAGGCCCCGTTCACCCGCTGGTCGACCCCCTGACTGCCGGTCCCCACCTGGCTCGCTTCCCCTACCCGCCTGGCACTCTCCCCA
ACCCTCTGCTTGGACAGCCCCCACACGAGCACGAGATGCTTCGCCACCCAGTTTTCGGCACCCCCTACCCCCGTGACCTGCCTGGGGCCA
TCCCACCCCCCATGTCAGCAGCCCACCAGCTGCAGGCCATGCATGCCCAGTCGGCCGAGCTGCAGAGACTGGCCATGGAGCAGCAGTGGC
TGCATGGACACCCCCACATGCATGGTGGCCACCTACCAAGTCAGGAAGATTATTACAGTCGACTGAAGAAAGAAGGTGACAAGCAGTTAT
AAGTTATTTATTTGTTAACGCTGGCTGTGGAAACCCCAGTTCTTGGGGGGAGAAACAGGACTTTTTACATAAAATAGGAGCTGCAAAAGC
AAAAAGAATATCTTCTAAAGATTTCTTTATATATTTAAAAACCCACAACTAAAAATGTATCCACATAGTAGTGTTCGTTTGTCGAGAGGA
TTTCCTGAGACTGGTTTGGATCTCCCTGCATGACAGTCCCCCAGAAACTTAGTGAGTCCTGGACTGGACTGAACATCCAGAAAGCTTCCC
TGCAATCTTGGGGTTTGGCTTTAGTTTTCTTTTCCTTGATTTCTCAGTAGGTGCTAGAATCCAGTTCACACCCTTCACTGTGCGTGCAGA
CACACTGACACACTCCGCCACGAGTGCTCCAGAGCCCACGAGGCTTGCAGATCGGGGGCATAGGAATTTGGAATCCAAGAGCTATAATTT
TTAAAAAAAAAAATCTTTTATTTTAATACATTGTAGGAAATCTTCATAATTGGAGAAAGTTCTGCAGCATGGCTTTTTACGTCTGTAAAT
AAATAATTTTAGAACAGCCTTTTTTTCTTCCATAAACTACTATTGTGATCTATTTTTTCCAGCCATGTCACTAATTGTGAATTCCTACCA
ACTATTGACAGAATACAGAGTTGATTTTTTAATAAAAAGTTATATATAATTATCCCTTTAATTAAAGGGAGCAAAGGGGCGTTCCACATG
GACAGAGGCTTGGACCGAGGCCTGGTCACAGCAGCGAGCATCCAGGGTTTGCAGGGACGATGTTACAGACTCTGTTTTCTGCCTGGCGTT
TCACTTGTGTCTGCTCCTAGCCTGTGCTCTGCCAGCAGCACAGACATCTGCTCCATCAGACCTCTTCCATTTTGCACAGGGAGTGCAGGA
GGTGAATGTTCACTTTCTGTTCTCCAGTGTCACTGTTCTGTTTCCACGGGATGGAAAGCGCATGGGCCTGTGTCCATTGTAGATTTCCTT
CTAGATTTCTGTGTACACACACTTGATTGTTCTGGATGAATGTCTTTTTTAATACTCCGAAAATTTCATCATCTAAGAAAATGATTCCAT
ACAAATAACTCAGCACACAAGTGACCCAGGACATATGCCTGCCAAAGGGATGTGTTAGAAGGCTGCCTTCTCATGCGCATTGTCACTTGG
ATCTTGTGGTGAGGACGGCCCCATCTTTCTTGCCACAGATTGAGGCCACTTTTGAGCAAGGGAGATCCTGGAGTTAAGACAGGTGTTGGG
GGCAGCCTGTATTTTACCCTAGGGGCAGGTCTGCATGGTGACCCCACATTGCACTGGTAAACCATTTGAGTCCCACTCTTCATCCTGGAA
GTGGGAACTGGAGTCCCACCCACAGTGCATTCAGAAAGCATGCTGTGTGGGGGCTGCTTCTCAGGAGGCCAGGCCCTTCTGAGCGGAACC
GTCCTGGAGAGAGCCTGCCCTCGTTTCCAGGCTGCAGCCGTAACGCACTTTCTCCCAGGCTGAGGGCGGGTGTTCTGGGGTGTCTGCCCT
CTGTCGGCCCTGCTTCCTGCCAGGACGTGGCCTCTTCCGATCCTTTTCTCTCAGACACTGGAGGTCTCTTCTGCCATTGTGCTGGTCCCA
TCCCAAGAATTGTAGGACAGAGACCACACTGGGTCGGCGGACACAAAGTCCATCCAGGACCCAGGCCGCAGAGGGAGCAGGAAGAGATGC
TGATAGTTTGATCTAGAAACCAGCAGCTACTGGCTCAAATTCAGGTTCTGGCGTCAAATAGCGACATTTCCAGTTTCTCTTAAAAACCGT
GTTTGGTTTCAGTTGGGATAGGCTTGTTTTGTCTGTTGAAAATGTTTCTAGTTTTTTTTCTTTCATTTTTCTCTCATTCCATTTCTGCCT
TAACTTTAGTTTGTTCACAGGGAGGCAAAGCTGACATGAACCTTTTGTCGTGGGACTTCAGGCCACATTGGCTTGAAGGCATTCGTTTCC
TTCTGGGGTGGGGACAGGCCCTCATGGCAGGCTTGTTCCCGTGGCTCTGAGCGAGGCCTCTTCCTGCTGGGCTCCCAGACTCCTGCATCC
AGGCCCCCACCTTCTCGGCTTCTGGTTTTTCTTTCTTTTTGGTAGAACACAACATCTACCATTCAGTTAAACCTTCTTTATCTCCTCCTT
TGGCATCCATTTTTCCAAAGAAGAGTCGAGTCCTCTGAGGTCTGTGCTTGAAAGCCGTCCGAAGGCATTCTTGTTAGCTTTGCTTTTCTC
CCCATATCCCAAGGCGAAGCGCTGAGATTCTTCCATCTAAAAAACCCTCGACCCGAAACCCTCACCAGATAAACTACAGTTTGTTTAGGA
GGCCCTGACCTTCATGGTGTCTTTGAAGCCCAACCACTCGGTTTCCTTCGGATTTTCCTCCCTTTGTTCGGGGTTTGGTTTGGCTCCTCT
GTGTGTGTCCGTATCTTGTTCGGTGTCCTCGAGGTTGAGCTTCACTCCACTGCGGCAGAGGCAGCGTGCACACTCGGATTTGCTACGTTT
CTATATATCTTGAAGCTAAATGTATATATGAGTAGTTTGCCATGAGATAACACAGTGTAAACAGTAGACACCCAGAAATCGTGACTTCTG

>In-frame_ENST00000237530_ENST00000337907_TCGA-CH-5771-01A_RPN2_chr20_35842268_+_RERE_chr1_8617582_length(amino acids)=1790AA_start in transcript=209_stop in transcript=5581
MPRVPGVPCGGLLEPLSRAEVSPRLGLRRDLLGGMAPPGSSTVFLLALTIIASTWALTPTHYLTKHDVERLKASLDRPFTNLESAFYSIV
GLSSLGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSEDSSVTQIYHAVAALSGFGLPLASQEALS
ALTARLSKEETVLATVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQL
MNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVKLEHAKSVASRATVLQKTSFT
PVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIANTVESKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRE
LFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEEL
VWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVK
GLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSE
DSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRS
GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISR
PNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGP
TPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHS
LQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHK
HPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQ
HPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSH
ASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGR
LSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELRE
REIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRL
AAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHE

--------------------------------------------------------------
>In-frame_ENST00000373622_ENST00000337907_TCGA-CH-5771-01A_RPN2_chr20_35842268_+_RERE_chr1_8617582_length(transcript)=8061nt_BP=1192nt
GACTGGGATCCCGGCCGCGGCTGCTGGAAGCGTCGAAGCTCAGCGGGGCCGCGGACACTGACCTGTGCTTAGAACTCATCCTGGCCCGCA
GAGCCTGCCGCGAGTCCCTGGCGTCCCCTGTGGCGGGCTCTTGGAGCCACTTTCCCGAGCGGAAGTCAGCCCGCGGCTCGGACTCCGGCG
GGACCTGCTCGGAGGAATGGCGCCGCCGGGTTCAAGCACTGTCTTCCTGTTGGCCCTGACAATCATAGCCAGCACCTGGGCTCTGACGCC
CACTCACTACCTCACCAAGCATGACGTGGAGAGACTAAAAGCCTCGCTGGATCGCCCTTTCACAAATTTGGAATCTGCCTTCTACTCCAT
CGTGGGACTCAGCAGCCTTGGTGCTCAGGTGCCAGATGCAAAGATCTCTATTTCAAATGAGACCAAAGATCTGCTTCTGGCAGCTGTCAG
TGAGGACTCATCTGTTACCCAGATCTACCATGCAGTTGCAGCTCTAAGTGGCTTTGGCCTTCCCTTGGCATCCCAAGAAGCACTCAGTGC
CCTTACTGCTCGTCTCAGCAAGGAGGAGACTGTGCTGGCAACAGTCCAGGCTCTGCAGACAGCATCCCACCTGTCCCAGCAGGCTGACCT
GAGGAGCATCGTGGAGGAGATTGAGGACCTTGTTGCTCGCCTGGATGAACTCGGGGGCGTGTATCTCCAGTTTGAAGAAGGACTGGAAAC
AACAGCGTTATTTGTGGCTGCCACCTACAAGCTCATGGATCATGTGGGGACTGAGCCATCCATTAAGGAGGATCAGGTCATCCAGCTGAT
GAACGCGATCTTCAGCAAGAAGAACTTTGAGTCCCTCTCCGAAGCCTTCAGCGTGGCCTCTGCAGCTGCTGTGCTCTCGCATAATCGCTA
CCACGTGCCAGTTGTGGTTGTGCCTGAGGGCTCTGCTTCCGACACTCATGAACAGGCTATCTTGCGGTTGCAAGTCACCAATGTTCTGTC
TCAGCCTCTGACTCAGGCCACTGTTAAACTAGAACATGCTAAATCTGTTGCTTCCAGAGCCACTGTCCTCCAGAAGACATCCTTCACCCC
TGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTCAAATTTTCCAGTGGTTATTATGACTTCCTTGTCGAAGTTGAAGGTGACAACCG
GTATATTGCAAATACCGTAGAGAGTAAGAGGGACCATCTCCTCATGAACGTCAAATGGTACTACCGTCAATCTGAGGTTCCAGATTCTGT
GTATCAGCATTTGGTTCAGGATCGACATAATGAAAATGACTCTGGAAGAGAACTTGTCATTACAGACCCAGTTATCAAGAACCGAGAGCT
CTTCATTTCTGATTACGTTGACACTTACCATGCTGCTGCCCTTAGAGGGAAGTGTAACATCTCCCATTTTTCTGACATATTTGCTGCTAG
AGAGTTTAAAGCCCGAGTGGATTCATTTTTCTACATATTAGGATATAACCCTGAGACAAGGAGGCTGAACAGTACCCAGGGGGAGATTCG
TGTCGGTCCTAGTCATCAGGCCAAACTTCCAGATCTGCAACCATTTCCTTCTCCAGATGGTGATACAGTGACCCAACATGAGGAACTGGT
CTGGATGCCTGGAGTTAACGACTGTGACCTCCTTATGTACTTGAGGGCAGCAAGGAGCATGGCGGCATTTGCAGGAATGTGTGATGGAGG
CTCTACAGAGGACGGCTGTGTCGCAGCCTCTCGGGATGACACCACTCTGAATGCACTGAACACACTGCATGAAAGCGGTTACGATGCTGG
CAAAGCCCTGCAGCGCCTGGTGAAGAAGCCTGTGCCCAAGCTCATCGAGAAGTGCTGGACCGAGGACGAAGTGAAACGCTTCGTTAAGGG
ACTCAGGCAGTACGGGAAGAACTTCTTCAGAATTAGAAAGGAGCTGCTTCCCAATAAGGAAACAGGGGAGCTGATCACCTTCTATTACTA
TTGGAAGAAGACCCCCGAAGCAGCCAGCTCCCGAGCCCATCGTAGGCACCGCAGGCAGGCCGTGTTCAGGAGGATTAAGACTCGCACCGC
GTCCACACCCGTCAACACACCCTCCAGACCCCCGTCCAGTGAATTCTTGGACCTAAGTTCAGCCAGTGAAGATGACTTCGACAGTGAGGA
CAGTGAGCAGGAGCTGAAGGGGTACGCCTGCCGCCACTGCTTCACCACCACCTCCAAAGATTGGCACCACGGAGGCCGGGAGAACATCCT
GCTTTGCACCGACTGTCGCATCCACTTCAAGAAATACGGTGAGCTCCCGCCCATTGAGAAGCCCGTGGACCCGCCACCGTTTATGTTCAA
ACCCGTCAAGGAAGAGGATGATGGGCTCAGTGGGAAGCATAGCATGAGGACACGGCGGAGTCGGGGCTCGATGTCGACACTACGCAGTGG
TCGGAAGAAGCAGCCAGCCAGCCCTGATGGTCGCACCTCACCCATCAATGAAGACATCCGCTCCAGCGGCCGGAACTCCCCCAGCGCTGC
CAGTACCTCCAGCAATGACAGTAAAGCAGAGACAGTGAAGAAGTCGGCCAAGAAGGTGAAGGAGGAAGCCTCTTCCCCTCTTAAGAGTAA
CAAACGCCAGCGGGAGAAGGTGGCCTCTGATACGGAGGAGGCTGACAGGACCAGCTCCAAGAAGACAAAAACGCAGGAGATCAGCAGGCC
CAACTCGCCATCTGAAGGTGAGGGAGAGAGTTCAGACAGTCGCAGCGTCAACGATGAGGGTAGCAGTGACCCCAAAGACATCGACCAGGA
CAATCGCAGCACGTCCCCGAGCATCCCCAGCCCCCAGGACAATGAGAGTGACTCGGACTCGTCAGCCCAGCAGCAGATGCTGCAGGCCCA
GCCCCCAGCCTTGCAGGCTCCCACTGGGGTCACCCCAGCTCCCTCCTCAGCTCCTCCAGGGACCCCTCAGCTGCCCACGCCAGGGCCCAC
GCCCTCTGCCACTGCAGTTCCCCCACAGGGCTCCCCCACGGCCTCCCAGGCCCCTAACCAGCCACAGGCTCCCACAGCGCCTGTTCCCCA
CACCCACATCCAACAGGCACCGGCCTTGCACCCCCAGCGGCCGCCCTCACCGCATCCCCCGCCGCATCCCTCGCCACATCCCCCGCTGCA
GCCTCTGACTGGGTCGGCGGGCCAGCCTTCTGCACCCTCTCATGCCCAGCCCCCACTGCACGGTCAGGGCCCACCCGGCCCTCACAGCCT
GCAGGCTGGGCCCCTGCTGCAGCACCCAGGCCCCCCACAGCCCTTTGGCCTCCCTCCCCAGGCCTCCCAAGGCCAGGCCCCTCTGGGGAC
CTCCCCAGCAGCAGCGTACCCTCACACCTCCCTGCAGCTGCCAGCCTCTCAGTCAGCGCTGCAGTCCCAACAGCCTCCACGGGAGCAGCC
CCTGCCACCAGCGCCCTTGGCCATGCCCCACATCAAGCCCCCGCCTACCACTCCCATCCCCCAGCTGCCGGCGCCACAGGCCCACAAGCA
CCCTCCCCACCTCTCGGGGCCCTCACCCTTCTCCATGAATGCCAACCTGCCTCCCCCTCCAGCCCTGAAGCCCCTGAGCTCCCTGTCCAC
ACATCACCCCCCGTCGGCTCACCCCCCACCCCTGCAACTCATGCCTCAGAGCCAGCCATTGCCCTCCTCGCCCGCCCAGCCCCCCGGGCT
GACCCAGAGCCAGAACCTGCCCCCGCCCCCTGCCTCCCACCCCCCTACAGGCCTCCACCAGGTGGCCCCCCAACCCCCGTTTGCTCAGCA
CCCCTTTGTCCCTGGAGGCCCTCCTCCCATCACCCCTCCGACCTGCCCCTCCACCTCTACCCCACCGGCGGGACCTGGCACCTCGGCCCA
GCCACCCTGCTCTGGTGCGGCGGCTTCAGGAGGCAGCATAGCGGGGGGGTCGTCCTGCCCACTCCCCACCGTCCAGATCAAGGAGGAGGC
TCTGGACGACGCTGAGGAGCCTGAGAGCCCCCCTCCCCCACCAAGGAGCCCGTCCCCGGAGCCCACTGTGGTGGACACCCCCAGTCACGC
CAGCCAGTCAGCTAGGTTCTACAAACACCTGGACCGGGGCTACAACTCGTGTGCCCGGACAGACCTGTACTTCATGCCTCTGGCCGGGTC
CAAGCTGGCCAAGAAGAGGGAGGAGGCCATTGAGAAGGCCAAGCGCGAGGCTGAGCAGAAAGCCCGAGAGGAGCGAGAGCGGGAGAAGGA
GAAGGAGAAGGAGCGGGAGCGGGAGCGAGAGCGGGAGCGCGAGGCAGAGCGGGCGGCTAAGGCGTCCAGCTCAGCGCATGAAGGTCGCCT
CAGTGACCCACAGCTCAGTGGTCCTGGCCACATGCGGCCATCCTTCGAGCCACCACCAACCACCATTGCTGCTGTGCCCCCCTACATCGG
GCCCGACACACCTGCCCTTCGGACTCTGAGCGAGTACGCCCGGCCCCACGTCATGTCGCCCACCAACCGCAACCACCCCTTCTACATGCC
CCTTAACCCCACGGACCCCCTGCTGGCCTACCACATGCCTGGCCTCTACAACGTCGACCCCACCATCCGCGAGCGGGAGCTCCGGGAGCG
GGAGATCCGAGAGCGGGAGATCCGAGAGCGGGAGCTGCGGGAGAGGATGAAGCCGGGCTTCGAGGTGAAGCCCCCAGAGCTGGACCCCCT
GCACCCAGCCGCCAACCCCATGGAGCACTTTGCCCGGCACAGCGCCCTCACCATCCCCCCGACCGCCGGGCCCCACCCTTTTGCTTCTTT
CCACCCGGGCCTGAACCCCTTGGAGAGGGAGAGACTGGCCCTGGCGGGCCCCCAGCTGCGGCCCGAGATGAGCTACCCTGACAGACTGGC
AGCCGAGCGTATCCACGCAGAGCGCATGGCATCGCTGACCAGCGATCCCCTGGCCCGACTGCAGATGTTCAACGTGACTCCGCACCATCA
CCAGCACTCTCACATTCACTCCCACCTCCACCTCCACCAGCAGGACCCCCTCCACCAAGGTTCAGCAGGCCCCGTTCACCCGCTGGTCGA
CCCCCTGACTGCCGGTCCCCACCTGGCTCGCTTCCCCTACCCGCCTGGCACTCTCCCCAACCCTCTGCTTGGACAGCCCCCACACGAGCA
CGAGATGCTTCGCCACCCAGTTTTCGGCACCCCCTACCCCCGTGACCTGCCTGGGGCCATCCCACCCCCCATGTCAGCAGCCCACCAGCT
GCAGGCCATGCATGCCCAGTCGGCCGAGCTGCAGAGACTGGCCATGGAGCAGCAGTGGCTGCATGGACACCCCCACATGCATGGTGGCCA
CCTACCAAGTCAGGAAGATTATTACAGTCGACTGAAGAAAGAAGGTGACAAGCAGTTATAAGTTATTTATTTGTTAACGCTGGCTGTGGA
AACCCCAGTTCTTGGGGGGAGAAACAGGACTTTTTACATAAAATAGGAGCTGCAAAAGCAAAAAGAATATCTTCTAAAGATTTCTTTATA
TATTTAAAAACCCACAACTAAAAATGTATCCACATAGTAGTGTTCGTTTGTCGAGAGGATTTCCTGAGACTGGTTTGGATCTCCCTGCAT
GACAGTCCCCCAGAAACTTAGTGAGTCCTGGACTGGACTGAACATCCAGAAAGCTTCCCTGCAATCTTGGGGTTTGGCTTTAGTTTTCTT
TTCCTTGATTTCTCAGTAGGTGCTAGAATCCAGTTCACACCCTTCACTGTGCGTGCAGACACACTGACACACTCCGCCACGAGTGCTCCA
GAGCCCACGAGGCTTGCAGATCGGGGGCATAGGAATTTGGAATCCAAGAGCTATAATTTTTAAAAAAAAAAATCTTTTATTTTAATACAT
TGTAGGAAATCTTCATAATTGGAGAAAGTTCTGCAGCATGGCTTTTTACGTCTGTAAATAAATAATTTTAGAACAGCCTTTTTTTCTTCC
ATAAACTACTATTGTGATCTATTTTTTCCAGCCATGTCACTAATTGTGAATTCCTACCAACTATTGACAGAATACAGAGTTGATTTTTTA
ATAAAAAGTTATATATAATTATCCCTTTAATTAAAGGGAGCAAAGGGGCGTTCCACATGGACAGAGGCTTGGACCGAGGCCTGGTCACAG
CAGCGAGCATCCAGGGTTTGCAGGGACGATGTTACAGACTCTGTTTTCTGCCTGGCGTTTCACTTGTGTCTGCTCCTAGCCTGTGCTCTG
CCAGCAGCACAGACATCTGCTCCATCAGACCTCTTCCATTTTGCACAGGGAGTGCAGGAGGTGAATGTTCACTTTCTGTTCTCCAGTGTC
ACTGTTCTGTTTCCACGGGATGGAAAGCGCATGGGCCTGTGTCCATTGTAGATTTCCTTCTAGATTTCTGTGTACACACACTTGATTGTT
CTGGATGAATGTCTTTTTTAATACTCCGAAAATTTCATCATCTAAGAAAATGATTCCATACAAATAACTCAGCACACAAGTGACCCAGGA
CATATGCCTGCCAAAGGGATGTGTTAGAAGGCTGCCTTCTCATGCGCATTGTCACTTGGATCTTGTGGTGAGGACGGCCCCATCTTTCTT
GCCACAGATTGAGGCCACTTTTGAGCAAGGGAGATCCTGGAGTTAAGACAGGTGTTGGGGGCAGCCTGTATTTTACCCTAGGGGCAGGTC
TGCATGGTGACCCCACATTGCACTGGTAAACCATTTGAGTCCCACTCTTCATCCTGGAAGTGGGAACTGGAGTCCCACCCACAGTGCATT
CAGAAAGCATGCTGTGTGGGGGCTGCTTCTCAGGAGGCCAGGCCCTTCTGAGCGGAACCGTCCTGGAGAGAGCCTGCCCTCGTTTCCAGG
CTGCAGCCGTAACGCACTTTCTCCCAGGCTGAGGGCGGGTGTTCTGGGGTGTCTGCCCTCTGTCGGCCCTGCTTCCTGCCAGGACGTGGC
CTCTTCCGATCCTTTTCTCTCAGACACTGGAGGTCTCTTCTGCCATTGTGCTGGTCCCATCCCAAGAATTGTAGGACAGAGACCACACTG
GGTCGGCGGACACAAAGTCCATCCAGGACCCAGGCCGCAGAGGGAGCAGGAAGAGATGCTGATAGTTTGATCTAGAAACCAGCAGCTACT
GGCTCAAATTCAGGTTCTGGCGTCAAATAGCGACATTTCCAGTTTCTCTTAAAAACCGTGTTTGGTTTCAGTTGGGATAGGCTTGTTTTG
TCTGTTGAAAATGTTTCTAGTTTTTTTTCTTTCATTTTTCTCTCATTCCATTTCTGCCTTAACTTTAGTTTGTTCACAGGGAGGCAAAGC
TGACATGAACCTTTTGTCGTGGGACTTCAGGCCACATTGGCTTGAAGGCATTCGTTTCCTTCTGGGGTGGGGACAGGCCCTCATGGCAGG
CTTGTTCCCGTGGCTCTGAGCGAGGCCTCTTCCTGCTGGGCTCCCAGACTCCTGCATCCAGGCCCCCACCTTCTCGGCTTCTGGTTTTTC
TTTCTTTTTGGTAGAACACAACATCTACCATTCAGTTAAACCTTCTTTATCTCCTCCTTTGGCATCCATTTTTCCAAAGAAGAGTCGAGT
CCTCTGAGGTCTGTGCTTGAAAGCCGTCCGAAGGCATTCTTGTTAGCTTTGCTTTTCTCCCCATATCCCAAGGCGAAGCGCTGAGATTCT
TCCATCTAAAAAACCCTCGACCCGAAACCCTCACCAGATAAACTACAGTTTGTTTAGGAGGCCCTGACCTTCATGGTGTCTTTGAAGCCC
AACCACTCGGTTTCCTTCGGATTTTCCTCCCTTTGTTCGGGGTTTGGTTTGGCTCCTCTGTGTGTGTCCGTATCTTGTTCGGTGTCCTCG
AGGTTGAGCTTCACTCCACTGCGGCAGAGGCAGCGTGCACACTCGGATTTGCTACGTTTCTATATATCTTGAAGCTAAATGTATATATGA
GTAGTTTGCCATGAGATAACACAGTGTAAACAGTAGACACCCAGAAATCGTGACTTCTGTGTTCTCTCCATTTGAGTATTTTGTAATTTT

>In-frame_ENST00000373622_ENST00000337907_TCGA-CH-5771-01A_RPN2_chr20_35842268_+_RERE_chr1_8617582_length(amino acids)=1758AA_start in transcript=94_stop in transcript=5370
MPRVPGVPCGGLLEPLSRAEVSPRLGLRRDLLGGMAPPGSSTVFLLALTIIASTWALTPTHYLTKHDVERLKASLDRPFTNLESAFYSIV
GLSSLGAQVPDAKISISNETKDLLLAAVSEDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLR
SIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYH
VPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRY
IANTVESKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAARE
FKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGS
TEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYW
KKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILL
CTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAAS
TSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDN
RSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHT
HIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTS
PAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTH
HPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQP
PCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSK
LAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGP
DTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLH
PAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQ
HSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPN2-RERE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPN2-RERE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPN2-RERE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPN2C0033578Prostatic Neoplasms1CTD_human
HgeneRPN2C0376358Malignant neoplasm of prostate1CTD_human
TgeneREREC4310772NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT ANOMALIES OF THE BRAIN, EYE, OR HEART3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneREREC0087031Juvenile-Onset Still Disease1CTD_human
TgeneREREC1842870Chromosome 1p36 Deletion Syndrome1ORPHANET
TgeneREREC3495559Juvenile arthritis1CTD_human
TgeneREREC3714758Juvenile psoriatic arthritis1CTD_human
TgeneREREC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneREREC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human