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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS15A-PICALM (FusionGDB2 ID:76946)

Fusion Gene Summary for RPS15A-PICALM

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS15A-PICALM
Fusion gene ID: 76946
HgeneTgene
Gene symbol

RPS15A

PICALM

Gene ID

6210

8301

Gene nameribosomal protein S15aphosphatidylinositol binding clathrin assembly protein
SynonymsDBA20|S15aCALM|CLTH|LAP
Cytomap

16p12.3

11q14.2

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S15asmall ribosomal subunit protein uS8up-regulated by HBV X proteinphosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020031320200322
UniProtAcc.

Q13492

Ensembl transtripts involved in fusion geneENST00000322989, ENST00000563390, 
ENST00000575669, ENST00000576436, 
ENST00000565420, ENST00000569083, 
ENST00000532317, ENST00000526033, 
ENST00000393346, ENST00000528398, 
ENST00000356360, ENST00000528411, 
Fusion gene scores* DoF score7 X 6 X 3=12635 X 26 X 12=10920
# samples 844
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS15A [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS15A(18799385)-PICALM(85689136), # samples:1
Anticipated loss of major functional domain due to fusion event.RPS15A-PICALM seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPS15A-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
RPS15A-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS15A

GO:0008284

positive regulation of cell proliferation

15108328

HgeneRPS15A

GO:0009615

response to virus

15108328

HgeneRPS15A

GO:0045787

positive regulation of cell cycle

15108328

TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across RPS15A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5798-01ARPS15Achr16

18799385

-PICALMchr11

85689136

-


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Fusion Gene ORF analysis for RPS15A-PICALM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000322989ENST00000532317RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000322989ENST00000526033RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000322989ENST00000393346RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000322989ENST00000528398RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000322989ENST00000356360RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000322989ENST00000528411RPS15Achr16

18799385

-PICALMchr11

85689136

-
In-frameENST00000563390ENST00000532317RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000563390ENST00000526033RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000563390ENST00000393346RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000563390ENST00000528398RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000563390ENST00000356360RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000563390ENST00000528411RPS15Achr16

18799385

-PICALMchr11

85689136

-
intron-3CDSENST00000575669ENST00000532317RPS15Achr16

18799385

-PICALMchr11

85689136

-
intron-intronENST00000575669ENST00000526033RPS15Achr16

18799385

-PICALMchr11

85689136

-
intron-intronENST00000575669ENST00000393346RPS15Achr16

18799385

-PICALMchr11

85689136

-
intron-intronENST00000575669ENST00000528398RPS15Achr16

18799385

-PICALMchr11

85689136

-
intron-intronENST00000575669ENST00000356360RPS15Achr16

18799385

-PICALMchr11

85689136

-
intron-intronENST00000575669ENST00000528411RPS15Achr16

18799385

-PICALMchr11

85689136

-
In-frameENST00000576436ENST00000532317RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000576436ENST00000526033RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000576436ENST00000393346RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000576436ENST00000528398RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000576436ENST00000356360RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000576436ENST00000528411RPS15Achr16

18799385

-PICALMchr11

85689136

-
Frame-shiftENST00000565420ENST00000532317RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000565420ENST00000526033RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000565420ENST00000393346RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000565420ENST00000528398RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000565420ENST00000356360RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000565420ENST00000528411RPS15Achr16

18799385

-PICALMchr11

85689136

-
In-frameENST00000569083ENST00000532317RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000569083ENST00000526033RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000569083ENST00000393346RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000569083ENST00000528398RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000569083ENST00000356360RPS15Achr16

18799385

-PICALMchr11

85689136

-
5CDS-intronENST00000569083ENST00000528411RPS15Achr16

18799385

-PICALMchr11

85689136

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000322989RPS15Achr1618799385-ENST00000532317PICALMchr1185689136-187530996512138
ENST00000563390RPS15Achr1618799385-ENST00000532317PICALMchr1185689136-185829279495138
ENST00000576436RPS15Achr1618799385-ENST00000532317PICALMchr1185689136-180323724440138
ENST00000569083RPS15Achr1618799385-ENST00000532317PICALMchr1185689136-17852196422138

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000322989ENST00000532317RPS15Achr1618799385-PICALMchr1185689136-0.0057354680.99426454
ENST00000563390ENST00000532317RPS15Achr1618799385-PICALMchr1185689136-0.0062470170.993753
ENST00000576436ENST00000532317RPS15Achr1618799385-PICALMchr1185689136-0.0044376440.9955623
ENST00000569083ENST00000532317RPS15Achr1618799385-PICALMchr1185689136-0.0048791460.9951208

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Fusion Genomic Features for RPS15A-PICALM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS15A-PICALM


check button Go to

FGviewer for the breakpoints of chr16:18799385-chr11:85689136

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PICALM

Q13492

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePICALMchr16:18799385chr11:85689136ENST0000035636001914_1450.0633.0DomainENTH
TgenePICALMchr16:18799385chr11:85689136ENST0000039334602014_1450653.0DomainENTH
TgenePICALMchr16:18799385chr11:85689136ENST0000052603302014_1450646.0DomainENTH
TgenePICALMchr16:18799385chr11:85689136ENST0000052839801914_1450552.0DomainENTH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePICALMchr16:18799385chr11:85689136ENST00000532317152014_145543.0611.0DomainENTH


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Fusion Gene Sequence for RPS15A-PICALM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000322989_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(transcript)=1875nt_BP=309nt
CTCTTTCCGCCATCTTTCCGCGCCGGTGAGTAGCACTCTCTGAGAGCTCCAATTTCATCCGTCTGCCATCGGCGCCATCCTGCAATCTAA
GCCACAATGGTGCGCATGAATGTCCTGGCAGATGCTCTCAAGAGTATCAACAATGCCGAAAAGAGAGGCAAACGCCAGGTGCTTATTAGG
CCGTGCTCCAAAGTCATCGTCCGGTTTCTCACTGTGATGATGAAGCATGGTTACATTGGCGAATTTGAAATCATTGATGACCACAGAGCT
GGGAAAATTGTTGTGAACCTCACAGGCAGGCTAAACAAGAATGGCATGCATTTTCCACAATACGCACCCCCTGTAATGGCCTATCCTGCT
ACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAG
CCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCC
AAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATT
AGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGA
ATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTA
TCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACA
GGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAA
ATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTAC
ATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGAT
TCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTG
TGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAA
AAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTA
GGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAG
GGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAA
AGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGT
GGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTC

>In-frame_ENST00000322989_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(amino acids)=138AA_start in transcript=96_stop in transcript=512
MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKNGMHFPQYAPPVMAYPATT

--------------------------------------------------------------
>In-frame_ENST00000563390_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(transcript)=1858nt_BP=292nt
GCGATAGCTCTCCCGCTTCCCATAACTCCGTGCGCTCTCCCCTCCCGTCCTCTTTCCGCCATCTTTCCGCGCCGCCACAATGGTGCGCAT
GAATGTCCTGGCAGATGCTCTCAAGAGTATCAACAATGCCGAAAAGAGAGGCAAACGCCAGGTGCTTATTAGGCCGTGCTCCAAAGTCAT
CGTCCGGTTTCTCACTGTGATGATGAAGCATGGTTACATTGGCGAATTTGAAATCATTGATGACCACAGAGCTGGGAAAATTGTTGTGAA
CCTCACAGGCAGGCTAAACAAGAATGGCATGCATTTTCCACAATACGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCAT
GATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCC
AAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCCAAAAAGACAAGTGCTCA
AGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAGAATGCTACAAGTAAC
TCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTAAGA
CTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTAT
TTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACAGGACTCTTTTGGGGGAT
CAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATTAACTTTTCTTTTTT
TAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTA
TCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGATTCAGAATGCTTTTCTCA
GCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCA
TTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACTACATTTTAAA
TTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGA
ATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTC
CTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAA
GAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGA
AGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATA

>In-frame_ENST00000563390_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(amino acids)=138AA_start in transcript=79_stop in transcript=495
MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKNGMHFPQYAPPVMAYPATT

--------------------------------------------------------------
>In-frame_ENST00000576436_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(transcript)=1803nt_BP=237nt
TTTTGTCTTCCTTGAACAGCCACAATGGTGCGCATGAATGTCCTGGCAGATGCTCTCAAGAGTATCAACAATGCCGAAAAGAGAGGCAAA
CGCCAGGTGCTTATTAGGCCGTGCTCCAAAGTCATCGTCCGGTTTCTCACTGTGATGATGAAGCATGGTTACATTGGCGAATTTGAAATC
ATTGATGACCACAGAGCTGGGAAAATTGTTGTGAACCTCACAGGCAGGCTAAACAAGAATGGCATGCATTTTCCACAATACGCACCCCCT
GTAATGGCCTATCCTGCTACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCA
ACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGA
AGAAAATGGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTT
AAACTCTCTTCTTCCATTAGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATA
CAGTTTATAAAGCCAAGAATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATA
CCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTC
CTTTACTGTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAAT
ACAGAAACAATAACTGAAATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATT
TATGATTATCAATTTTACATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATC
CACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTT
AAGAATTCTCGGCCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAA
CAGTTCACTGACTAGGAAAAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATT
ATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGA
AGGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAG
GGGAAATAGTATCTTTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATA
CATCTTTAACATTTGGGTGGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTG
CATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAATGTATGTTAGCAAAATGGGTGGATTTTCAAATAAAATGCAGCTTCCACA

>In-frame_ENST00000576436_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(amino acids)=138AA_start in transcript=24_stop in transcript=440
MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKNGMHFPQYAPPVMAYPATT

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>In-frame_ENST00000569083_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(transcript)=1785nt_BP=219nt
GCCACAATGGTGCGCATGAATGTCCTGGCAGATGCTCTCAAGAGTATCAACAATGCCGAAAAGAGAGGCAAACGCCAGGTGCTTATTAGG
CCGTGCTCCAAAGTCATCGTCCGGTTTCTCACTGTGATGATGAAGCATGGTTACATTGGCGAATTTGAAATCATTGATGACCACAGAGCT
GGGAAAATTGTTGTGAACCTCACAGGCAGGCTAAACAAGAATGGCATGCATTTTCCACAATACGCACCCCCTGTAATGGCCTATCCTGCT
ACTACACCAACAGGCATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATACAGCCAG
CCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAATGGAATTACTCC
AAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAGCAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATT
AGAATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTTATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGA
ATTGCTATGATTTAAGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGTTAATACCCATAATCAGTAACCTA
TCAAGAAAAGCCCTTATTTGGAAAGTGTGAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACTGTATTTCAACA
GGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGCATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAA
ATTAACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTAAGTATTTGTATTTATTTATGATTATCAATTTTAC
ATAACATTAATATTGTATCAGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTATCCACAAGAATGAATCTGAT
TCAGAATGCTTTTCTCAGCTGACATACAGAGCACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGGCCTCTG
TGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAATTCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAA
AAGCACTACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGCTTGGCATGTCATTATTTTCCATTTGACATTA
GGGCCTTTCCAAAATGAATGTGAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAAGGTGTTACAAGGGGGAG
GGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTGGCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCTTTAA
AGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCACTGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGT
GGAGAGGGGCCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAAGCATTCTTGTTGCATTGTCTCTGCAGATTC

>In-frame_ENST00000569083_ENST00000532317_TCGA-CD-5798-01A_RPS15A_chr16_18799385_-_PICALM_chr11_85689136_length(amino acids)=138AA_start in transcript=6_stop in transcript=422
MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKNGMHFPQYAPPVMAYPATT

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Fusion Gene PPI Analysis for RPS15A-PICALM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePICALMchr16:18799385chr11:85689136ENST00000356360019221_2940.0633.0PIMREG
TgenePICALMchr16:18799385chr11:85689136ENST00000393346020221_2940653.0PIMREG
TgenePICALMchr16:18799385chr11:85689136ENST00000526033020221_2940646.0PIMREG
TgenePICALMchr16:18799385chr11:85689136ENST00000528398019221_2940552.0PIMREG


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePICALMchr16:18799385chr11:85689136ENST000005323171520221_294543.0611.0PIMREG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS15A-PICALM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS15A-PICALM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS15AC1260899Anemia, Diamond-Blackfan1ORPHANET
HgeneRPS15AC2931850Aase Smith syndrome 21ORPHANET
TgenePICALMC0002395Alzheimer's Disease2CTD_human
TgenePICALMC0011265Presenile dementia2CTD_human
TgenePICALMC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgenePICALMC0494463Alzheimer Disease, Late Onset2CTD_human
TgenePICALMC0546126Acute Confusional Senile Dementia2CTD_human
TgenePICALMC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgenePICALMC0750901Alzheimer Disease, Early Onset2CTD_human
TgenePICALMC0234985Mental deterioration1CTD_human
TgenePICALMC0338656Impaired cognition1CTD_human
TgenePICALMC1270972Mild cognitive disorder1CTD_human