FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RPS16-FGA (FusionGDB2 ID:76986)

Fusion Gene Summary for RPS16-FGA

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS16-FGA
Fusion gene ID: 76986
HgeneTgene
Gene symbol

RPS16

FGA

Gene ID

6217

2243

Gene nameribosomal protein S16fibrinogen alpha chain
SynonymsS16Fib2
Cytomap

19q13.2

4q31.3

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S16small ribosomal subunit protein uS9fibrinogen alpha chainfibrinogen, A alpha polypeptide
Modification date2020031320200315
UniProtAcc.

P02671

Ensembl transtripts involved in fusion geneENST00000599539, ENST00000339471, 
ENST00000251453, ENST00000601655, 
ENST00000302053, ENST00000403106, 
Fusion gene scores* DoF score22 X 17 X 2=7486 X 5 X 3=90
# samples 256
** MAII scorelog2(25/748*10)=-1.58111017522555
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS16 [Title/Abstract] AND FGA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS16(39926560)-FGA(155507364), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGA

GO:0007160

cell-matrix adhesion

10903502

TgeneFGA

GO:0031639

plasminogen activation

16846481

TgeneFGA

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

TgeneFGA

GO:0034622

cellular protein-containing complex assembly

8910396

TgeneFGA

GO:0042730

fibrinolysis

16846481

TgeneFGA

GO:0043152

induction of bacterial agglutination

24367264

TgeneFGA

GO:0045907

positive regulation of vasoconstriction

15739255

TgeneFGA

GO:0045921

positive regulation of exocytosis

19193866

TgeneFGA

GO:0050714

positive regulation of protein secretion

19193866

TgeneFGA

GO:0051258

protein polymerization

12706644

TgeneFGA

GO:0051592

response to calcium ion

6777381

TgeneFGA

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

TgeneFGA

GO:0070527

platelet aggregation

6281794

TgeneFGA

GO:0072378

blood coagulation, fibrin clot formation

16846481

TgeneFGA

GO:0090277

positive regulation of peptide hormone secretion

19193866

TgeneFGA

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

TgeneFGA

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check buttonFusion gene breakpoints across RPS16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FGA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI114445RPS16chr19

39926560

+FGAchr4

155507364

-


Top

Fusion Gene ORF analysis for RPS16-FGA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000599539ENST00000302053RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000599539ENST00000403106RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000339471ENST00000302053RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000339471ENST00000403106RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000251453ENST00000302053RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000251453ENST00000403106RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000601655ENST00000302053RPS16chr19

39926560

+FGAchr4

155507364

-
intron-3CDSENST00000601655ENST00000403106RPS16chr19

39926560

+FGAchr4

155507364

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for RPS16-FGA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RPS16-FGA


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGA

P02671

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for RPS16-FGA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for RPS16-FGA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RPS16-FGA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGAP02671DB00009AlteplaseBiotechApproved
TgeneFGAP02671DB00029AnistreplaseBiotechApproved
TgeneFGAP02671DB00031TenecteplaseBiotechApproved
TgeneFGAP02671DB11311ProthrombinCleavageBiotechApproved
TgeneFGAP02671DB11571Human thrombinActivatorBiotechApproved
TgeneFGAP02671DB11572Thrombin alfaActivatorBiotechApproved
TgeneFGAP02671DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
TgeneFGAP02671DB00015ReteplaseBiotechApproved|Investigational
TgeneFGAP02671DB01593ZincSmall moleculeApproved|Investigational
TgeneFGAP02671DB05099AncrodBiotechApproved|Investigational
TgeneFGAP02671DB11300ThrombinActivatorBiotechApproved|Investigational
TgeneFGAP02671DB13151Anti-inhibitor coagulant complexCleavageBiotechApproved|Investigational
TgeneFGAP02671DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneFGAP02671DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational

Top

Related Diseases for RPS16-FGA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFGAC2584774Congenital hypofibrinogenemia8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGAC0272350Dysfibrinogenemia, Congenital5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGAC0001733Afibrinogenemia4CTD_human
TgeneFGAC4316812Fibrinogen Deficiency4CTD_human;GENOMICS_ENGLAND
TgeneFGAC0268389Amyloidosis, familial visceral3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGAC0022658Kidney Diseases2CTD_human
TgeneFGAC0740340Amyloidosis, Familial2CTD_human
TgeneFGAC0001787Osteoporosis, Age-Related1CTD_human
TgeneFGAC0008370Cholestasis1CTD_human
TgeneFGAC0013221Drug toxicity1CTD_human
TgeneFGAC0019193Hepatitis, Toxic1CTD_human
TgeneFGAC0026640Mouth Neoplasms1CTD_human
TgeneFGAC0029456Osteoporosis1CTD_human
TgeneFGAC0029459Osteoporosis, Senile1CTD_human
TgeneFGAC0034065Pulmonary Embolism1CTD_human
TgeneFGAC0038454Cerebrovascular accident1CTD_human
TgeneFGAC0040053Thrombosis1CTD_human;GENOMICS_ENGLAND
TgeneFGAC0041755Adverse reaction to drug1CTD_human
TgeneFGAC0087086Thrombus1CTD_human
TgeneFGAC0153381Malignant neoplasm of mouth1CTD_human
TgeneFGAC0398623Thrombophilia1CTD_human;GENOMICS_ENGLAND
TgeneFGAC0524702Pulmonary Thromboembolisms1CTD_human
TgeneFGAC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneFGAC0751956Acute Cerebrovascular Accidents1CTD_human
TgeneFGAC0860207Drug-Induced Liver Disease1CTD_human
TgeneFGAC1262760Hepatitis, Drug-Induced1CTD_human
TgeneFGAC1861172Venous Thromboembolism1CTD_human
TgeneFGAC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneFGAC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneFGAC4279912Chemically-Induced Liver Toxicity1CTD_human