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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RPS6KB1-CLTC (FusionGDB2 ID:77587) |
Fusion Gene Summary for RPS6KB1-CLTC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS6KB1-CLTC | Fusion gene ID: 77587 | Hgene | Tgene | Gene symbol | RPS6KB1 | CLTC | Gene ID | 6198 | 1213 |
| Gene name | ribosomal protein S6 kinase B1 | clathrin heavy chain | |
| Synonyms | PS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha | CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56 | |
| Cytomap | 17q23.1 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribosomal protein S6 kinase beta-1p70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14A | clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | P53675 | |
| Ensembl transtripts involved in fusion gene | ENST00000443572, ENST00000406116, ENST00000225577, ENST00000393021, ENST00000587061, | ENST00000393043, ENST00000269122, ENST00000579456, ENST00000579815, | |
| Fusion gene scores | * DoF score | 14 X 17 X 14=3332 | 18 X 18 X 8=2592 |
| # samples | 47 | 22 | |
| ** MAII score | log2(47/3332*10)=-2.82565573880055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2592*10)=-3.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPS6KB1 [Title/Abstract] AND CLTC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CLTC(57746301)-RPS6KB1(57987923), # samples:1 RPS6KB1(57970686)-CLTC(57762417), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPS6KB1 | GO:0031667 | response to nutrient levels | 29750193 |
| Hgene | RPS6KB1 | GO:0031929 | TOR signaling | 12150926 |
| Hgene | RPS6KB1 | GO:0071363 | cellular response to growth factor stimulus | 17936702 |
| Tgene | CLTC | GO:1900126 | negative regulation of hyaluronan biosynthetic process | 24251095 |
| Fusion gene breakpoints across RPS6KB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CLTC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-BP-5198-01A | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
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Fusion Gene ORF analysis for RPS6KB1-CLTC |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000443572 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000443572 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000443572 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5CDS-intron | ENST00000443572 | ENST00000579815 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000406116 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000406116 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000406116 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5CDS-intron | ENST00000406116 | ENST00000579815 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000225577 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000225577 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| In-frame | ENST00000225577 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5CDS-intron | ENST00000225577 | ENST00000579815 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5UTR-3CDS | ENST00000393021 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5UTR-3CDS | ENST00000393021 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5UTR-3CDS | ENST00000393021 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| 5UTR-intron | ENST00000393021 | ENST00000579815 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| intron-3CDS | ENST00000587061 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| intron-3CDS | ENST00000587061 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| intron-3CDS | ENST00000587061 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| intron-intron | ENST00000587061 | ENST00000579815 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000443572 | RPS6KB1 | chr17 | 57970686 | + | ENST00000393043 | CLTC | chr17 | 57762417 | + | 780 | 196 | 55 | 681 | 208 |
| ENST00000443572 | RPS6KB1 | chr17 | 57970686 | + | ENST00000269122 | CLTC | chr17 | 57762417 | + | 3248 | 196 | 55 | 789 | 244 |
| ENST00000443572 | RPS6KB1 | chr17 | 57970686 | + | ENST00000579456 | CLTC | chr17 | 57762417 | + | 1052 | 196 | 55 | 789 | 244 |
| ENST00000406116 | RPS6KB1 | chr17 | 57970686 | + | ENST00000393043 | CLTC | chr17 | 57762417 | + | 765 | 181 | 40 | 666 | 208 |
| ENST00000406116 | RPS6KB1 | chr17 | 57970686 | + | ENST00000269122 | CLTC | chr17 | 57762417 | + | 3233 | 181 | 40 | 774 | 244 |
| ENST00000406116 | RPS6KB1 | chr17 | 57970686 | + | ENST00000579456 | CLTC | chr17 | 57762417 | + | 1037 | 181 | 40 | 774 | 244 |
| ENST00000225577 | RPS6KB1 | chr17 | 57970686 | + | ENST00000393043 | CLTC | chr17 | 57762417 | + | 746 | 162 | 21 | 647 | 208 |
| ENST00000225577 | RPS6KB1 | chr17 | 57970686 | + | ENST00000269122 | CLTC | chr17 | 57762417 | + | 3214 | 162 | 21 | 755 | 244 |
| ENST00000225577 | RPS6KB1 | chr17 | 57970686 | + | ENST00000579456 | CLTC | chr17 | 57762417 | + | 1018 | 162 | 21 | 755 | 244 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000443572 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000502492 | 0.99949753 |
| ENST00000443572 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000270144 | 0.9997298 |
| ENST00000443572 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000478451 | 0.9995216 |
| ENST00000406116 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000509483 | 0.9994905 |
| ENST00000406116 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000266499 | 0.9997335 |
| ENST00000406116 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000435278 | 0.9995647 |
| ENST00000225577 | ENST00000393043 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000444997 | 0.99955493 |
| ENST00000225577 | ENST00000269122 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000253491 | 0.9997465 |
| ENST00000225577 | ENST00000579456 | RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762417 | + | 0.000429896 | 0.9995701 |
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Fusion Genomic Features for RPS6KB1-CLTC |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762416 | + | 9.77E-12 | 1 |
| RPS6KB1 | chr17 | 57970686 | + | CLTC | chr17 | 57762416 | + | 9.77E-12 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RPS6KB1-CLTC |
| Go to FGviewer for the breakpoints of chr17:57970686-chr17:57762417 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CLTC |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RPS6KB1 | chr17:57970686 | chr17:57762417 | ENST00000225577 | + | 1 | 15 | 28_32 | 47.0 | 526.0 | Motif | Note=TOS motif |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 1550_1675 | 1478.0 | 1676.0 | Region | Trimerization | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 1550_1675 | 1478.0 | 1640.0 | Region | Trimerization |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RPS6KB1 | chr17:57970686 | chr17:57762417 | ENST00000225577 | + | 1 | 15 | 353_423 | 47.0 | 526.0 | Domain | AGC-kinase C-terminal |
| Hgene | RPS6KB1 | chr17:57970686 | chr17:57762417 | ENST00000225577 | + | 1 | 15 | 91_352 | 47.0 | 526.0 | Domain | Protein kinase |
| Hgene | RPS6KB1 | chr17:57970686 | chr17:57762417 | ENST00000225577 | + | 1 | 15 | 97_105 | 47.0 | 526.0 | Nucleotide binding | ATP |
| Hgene | RPS6KB1 | chr17:57970686 | chr17:57762417 | ENST00000225577 | + | 1 | 15 | 424_525 | 47.0 | 526.0 | Region | Note=Autoinhibitory domain |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 108_149 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 3 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 1213_1522 | 1478.0 | 1676.0 | Region | Involved in binding clathrin light chain | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 150_195 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 4 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 196_257 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 5 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 24_67 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 1 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 258_301 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 6 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 2_479 | 1478.0 | 1676.0 | Region | Note=Globular terminal domain | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 302_330 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 7 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 449_465 | 1478.0 | 1676.0 | Region | Binding site for the uncoating ATPase%2C involved in lattice disassembly | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 480_523 | 1478.0 | 1676.0 | Region | Note=Flexible linker | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 524_1675 | 1478.0 | 1676.0 | Region | Note=Heavy chain arm | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 524_634 | 1478.0 | 1676.0 | Region | Note=Distal segment | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 639_1675 | 1478.0 | 1676.0 | Region | Note=Proximal segment | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 68_107 | 1478.0 | 1676.0 | Region | Note=WD40-like repeat 2 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 108_149 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 3 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 1213_1522 | 1478.0 | 1640.0 | Region | Involved in binding clathrin light chain | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 150_195 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 4 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 196_257 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 5 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 24_67 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 1 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 258_301 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 6 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 2_479 | 1478.0 | 1640.0 | Region | Note=Globular terminal domain | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 302_330 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 7 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 449_465 | 1478.0 | 1640.0 | Region | Binding site for the uncoating ATPase%2C involved in lattice disassembly | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 480_523 | 1478.0 | 1640.0 | Region | Note=Flexible linker | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 524_1675 | 1478.0 | 1640.0 | Region | Note=Heavy chain arm | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 524_634 | 1478.0 | 1640.0 | Region | Note=Distal segment | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 639_1675 | 1478.0 | 1640.0 | Region | Note=Proximal segment | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 68_107 | 1478.0 | 1640.0 | Region | Note=WD40-like repeat 2 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 1128_1269 | 1478.0 | 1676.0 | Repeat | CHCR 5 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 1274_1420 | 1478.0 | 1676.0 | Repeat | CHCR 6 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 1423_1566 | 1478.0 | 1676.0 | Repeat | CHCR 7 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 537_683 | 1478.0 | 1676.0 | Repeat | CHCR 1 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 686_828 | 1478.0 | 1676.0 | Repeat | CHCR 2 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 833_972 | 1478.0 | 1676.0 | Repeat | CHCR 3 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000269122 | 27 | 32 | 979_1124 | 1478.0 | 1676.0 | Repeat | CHCR 4 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 1128_1269 | 1478.0 | 1640.0 | Repeat | CHCR 5 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 1274_1420 | 1478.0 | 1640.0 | Repeat | CHCR 6 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 1423_1566 | 1478.0 | 1640.0 | Repeat | CHCR 7 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 537_683 | 1478.0 | 1640.0 | Repeat | CHCR 1 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 686_828 | 1478.0 | 1640.0 | Repeat | CHCR 2 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 833_972 | 1478.0 | 1640.0 | Repeat | CHCR 3 | |
| Tgene | CLTC | chr17:57970686 | chr17:57762417 | ENST00000393043 | 27 | 31 | 979_1124 | 1478.0 | 1640.0 | Repeat | CHCR 4 |
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Fusion Gene Sequence for RPS6KB1-CLTC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000443572_ENST00000393043_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=780nt_BP=196nt CTAAGCAGCCGGTGATGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCC AGCCCCGGACTTCCGAGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGA TGAGCTGGAGGAGGGGGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGA ACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCT TTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAG AGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGA TTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGA AGAACAAGCTACAGAGACACAACCCATTGTTTATGGTAATCTCTCTCTGTAACCTCAAAAAATTCATTAGACAAATATTTAATTACTTAG >In-frame_ENST00000443572_ENST00000393043_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=208AA_start in transcript=55_stop in transcript=681 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000443572_ENST00000269122_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=3248nt_BP=196nt CTAAGCAGCCGGTGATGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCC AGCCCCGGACTTCCGAGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGA TGAGCTGGAGGAGGGGGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGA ACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCT TTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAG AGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGA TTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGA AGAACAAGCTACAGAGACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGC ACCTTTTGGTTATGGTTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTA GTCACCTATTTTCGTACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATT TCATGAAGGACTTCTTTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTAT TTTCGAAGGGGAATAGTTTCAATGTTTTATTCACTTGGGCTTTTTTTCTTCCCCCTCTTTCTTTAAAGAACTGCTCAATATTCAATCTGT TGTGAAGAACCTGATTTGCACTCTGTAGTGTTTAAAGAAACAAAGAAACTCTAATATTGAATCTCTTAAATTTAGTGTATGTAAACAGCT TACAAATACGTATTGTCTAAATGCATTTAAATCTGTTTTATTCAAAGAAAAGCTAAAGCAAAAACACTGGCATATGACCATGCAAGACTG TCAGTGCCAACAAAGACAACACTAATCAGCACATCGTACACTGGATTGCAGTGCTTCCCAGATTATTGAAAAATGTTACAGACAACTTGC CTGATTTTTAAATGAGCGTAAAAGGCCCTCTAACCTATGCAGGTTTCCCCATTATGCATATAGAAAATGCTAGTATGTTTTGCTCACTTC ATATGTAACAGGTGCCCTTATGTTGTGCTGTATCCTGTGCTTTTTCTGTGGGACCATTCCATTCAGGAGCAAAGAGCACCATGATTCCAA TCTTGTGTGTGTTTACTAACCCTTCCCTGAGGTTTGTGTATGTTGGATATTGTGGTGTTTTAGATCACTGAGTGTACAGAAGAGAGAAAT TCAAACAAAATATTGCTGTTCTTCAGTTTTGTTTGTGGAATTTGAAATTACTCAAATTTAAAATAAATTACTGGACTGTGGAAATAACAT AGAATTGAAGTTTTAATTAAATACCACTCAAACGAAAAGAACAGTAGTTTTTGTAGTTTTATATTGGATACTGAGGCATTAGGGAGGCAT GAAAGGAAGAGGAATGAGGATTGAGACATGTGAAGACATTGTGCATTATATCAATGTGCATTCCTGTAGTTCATTAACAAGGTACATGCA ATAGTCTAAAGAACCAGAGTCACTACTATAGTGGCTTAACATTTAATCTGTCTCCAATATTTTAACCAAGTGACACCGAGGTTTTTATCG AAGCATTTCACTTAAATGAACAAATCATGGCTGTTATATTAACTTGAAATAAAATATATTTAAACATGTAGTTAACATGCTCTTTCTCAT CATGAATTATAAAGGTGCCCAAATTATGGGTATCTTGATTTTTTTCAAAAATTGGTTGTGTGAATCCAGCTCTTGCTTATGGCTGAGAAT GTTCCTAAAGTTCATTTCACTATCCCTTAATCCTCAATAGCTACACATACCCCCTTGCCTAGTTAGTCTTGCACTGCTTTACAACTCTCT TAGGCAAATTACCTAACATAAGCTCCACAGAAGAGTTTTTTAAAACTTAAAATCCCTGTCCCACCAGGTGTGGTGGCTCATGCCTGTAAT CCCAGCACTTTGGGAGGCTGAGGCAGGCGGATTGCTTGAGGCCAGGAGTTCGAGACAAGCCTGACCAACATGGTGACTCCATCTCTACTA AAAATAAAAAATCAGCCAGGTGTGATGGTGGATGCCTATAAGATCCTAGCTGCTACTCAGGAGGCAGGAGGCTGAGGCATGAGAATCACT TGAACCTGTGAGGCAAAGGTTGTAGTGAGCCAAGATCACGTCACTGCACTCCATCCTGGGTGACAGAATGAGACTCTTGTCTCAAAAAAC AAAAAAACCTATTTAGTTTCATCCAGGACATTAAGTGAAAGTGTTTAATGTGAGTGCAGGTCAGTGAAGAATACAATGGTGCCCCTGCTT TGATTTGTGGGAGGTGCCATCAGTTTTCCCCACCACTGCTTTTGCACCCTCAGTGCAAATATCAACACAGAGAAAAAAAAAATAATAATA GTATTATGAAAACATTGACTCTGTGGAGACCCTGTGGGTTCTGCAGAGTATACTTTGAAAACTATAAGATTATGAGTTCTATAAAATACC AAGTACAGATGAACTAGAAAACAAGCATATATCCACAATTACCAGAATTTTCATAGTATTCCTTTTAGTAGATATGCCATGACAGTTACT TAGCCACCCCATGCCATCCTGTTGGGAATGCCACTACCTTTGAATTTGGAGCCATCAGTCTATCTGAGGCAAACCTCAGAAATTACCTGA GCCAGAATCATGCACTTAGCACTGAGTTCAACTCAGTCTTAACGTTGCATTTTGTTGCATCACTTTTGCAGCCAGTAAACATTCTGTTTA GAAATAGTTGCTATTGTGGCATCATTCACAGTTGCAATTTTTCTCCTGTGCTGTCATATGCCTGTGCGAAGTGTATTAAATGAATCAAAT >In-frame_ENST00000443572_ENST00000269122_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=244AA_start in transcript=55_stop in transcript=789 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000443572_ENST00000579456_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=1052nt_BP=196nt CTAAGCAGCCGGTGATGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCC AGCCCCGGACTTCCGAGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGA TGAGCTGGAGGAGGGGGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGA ACTCATTGAGTTCAGGAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCT TTACAAGGATGCAATGCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAG AGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGA TTTTGCCATGCCCTATTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGA AGAACAAGCTACAGAGACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGC ACCTTTTGGTTATGGTTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTA GTCACCTATTTTCGTACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATT TCATGAAGGACTTCTTTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTAT >In-frame_ENST00000443572_ENST00000579456_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=244AA_start in transcript=55_stop in transcript=789 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000406116_ENST00000393043_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=765nt_BP=181nt TGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCG AGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGG GGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAG GAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAAT GCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGC TTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTA TTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGA GACACAACCCATTGTTTATGGTAATCTCTCTCTGTAACCTCAAAAAATTCATTAGACAAATATTTAATTACTTAGAGACTGTGCCTCAAA >In-frame_ENST00000406116_ENST00000393043_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=208AA_start in transcript=40_stop in transcript=666 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000406116_ENST00000269122_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=3233nt_BP=181nt TGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCG AGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGG GGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAG GAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAAT GCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGC TTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTA TTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGA GACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGG TTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGT ACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCT TTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATA GTTTCAATGTTTTATTCACTTGGGCTTTTTTTCTTCCCCCTCTTTCTTTAAAGAACTGCTCAATATTCAATCTGTTGTGAAGAACCTGAT TTGCACTCTGTAGTGTTTAAAGAAACAAAGAAACTCTAATATTGAATCTCTTAAATTTAGTGTATGTAAACAGCTTACAAATACGTATTG TCTAAATGCATTTAAATCTGTTTTATTCAAAGAAAAGCTAAAGCAAAAACACTGGCATATGACCATGCAAGACTGTCAGTGCCAACAAAG ACAACACTAATCAGCACATCGTACACTGGATTGCAGTGCTTCCCAGATTATTGAAAAATGTTACAGACAACTTGCCTGATTTTTAAATGA GCGTAAAAGGCCCTCTAACCTATGCAGGTTTCCCCATTATGCATATAGAAAATGCTAGTATGTTTTGCTCACTTCATATGTAACAGGTGC CCTTATGTTGTGCTGTATCCTGTGCTTTTTCTGTGGGACCATTCCATTCAGGAGCAAAGAGCACCATGATTCCAATCTTGTGTGTGTTTA CTAACCCTTCCCTGAGGTTTGTGTATGTTGGATATTGTGGTGTTTTAGATCACTGAGTGTACAGAAGAGAGAAATTCAAACAAAATATTG CTGTTCTTCAGTTTTGTTTGTGGAATTTGAAATTACTCAAATTTAAAATAAATTACTGGACTGTGGAAATAACATAGAATTGAAGTTTTA ATTAAATACCACTCAAACGAAAAGAACAGTAGTTTTTGTAGTTTTATATTGGATACTGAGGCATTAGGGAGGCATGAAAGGAAGAGGAAT GAGGATTGAGACATGTGAAGACATTGTGCATTATATCAATGTGCATTCCTGTAGTTCATTAACAAGGTACATGCAATAGTCTAAAGAACC AGAGTCACTACTATAGTGGCTTAACATTTAATCTGTCTCCAATATTTTAACCAAGTGACACCGAGGTTTTTATCGAAGCATTTCACTTAA ATGAACAAATCATGGCTGTTATATTAACTTGAAATAAAATATATTTAAACATGTAGTTAACATGCTCTTTCTCATCATGAATTATAAAGG TGCCCAAATTATGGGTATCTTGATTTTTTTCAAAAATTGGTTGTGTGAATCCAGCTCTTGCTTATGGCTGAGAATGTTCCTAAAGTTCAT TTCACTATCCCTTAATCCTCAATAGCTACACATACCCCCTTGCCTAGTTAGTCTTGCACTGCTTTACAACTCTCTTAGGCAAATTACCTA ACATAAGCTCCACAGAAGAGTTTTTTAAAACTTAAAATCCCTGTCCCACCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA GGCTGAGGCAGGCGGATTGCTTGAGGCCAGGAGTTCGAGACAAGCCTGACCAACATGGTGACTCCATCTCTACTAAAAATAAAAAATCAG CCAGGTGTGATGGTGGATGCCTATAAGATCCTAGCTGCTACTCAGGAGGCAGGAGGCTGAGGCATGAGAATCACTTGAACCTGTGAGGCA AAGGTTGTAGTGAGCCAAGATCACGTCACTGCACTCCATCCTGGGTGACAGAATGAGACTCTTGTCTCAAAAAACAAAAAAACCTATTTA GTTTCATCCAGGACATTAAGTGAAAGTGTTTAATGTGAGTGCAGGTCAGTGAAGAATACAATGGTGCCCCTGCTTTGATTTGTGGGAGGT GCCATCAGTTTTCCCCACCACTGCTTTTGCACCCTCAGTGCAAATATCAACACAGAGAAAAAAAAAATAATAATAGTATTATGAAAACAT TGACTCTGTGGAGACCCTGTGGGTTCTGCAGAGTATACTTTGAAAACTATAAGATTATGAGTTCTATAAAATACCAAGTACAGATGAACT AGAAAACAAGCATATATCCACAATTACCAGAATTTTCATAGTATTCCTTTTAGTAGATATGCCATGACAGTTACTTAGCCACCCCATGCC ATCCTGTTGGGAATGCCACTACCTTTGAATTTGGAGCCATCAGTCTATCTGAGGCAAACCTCAGAAATTACCTGAGCCAGAATCATGCAC TTAGCACTGAGTTCAACTCAGTCTTAACGTTGCATTTTGTTGCATCACTTTTGCAGCCAGTAAACATTCTGTTTAGAAATAGTTGCTATT >In-frame_ENST00000406116_ENST00000269122_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=244AA_start in transcript=40_stop in transcript=774 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000406116_ENST00000579456_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=1037nt_BP=181nt TGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCG AGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGG GGCTCTGCGAACATCAATAGATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAG GAGAATTGCTGCTTATCTCTTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAAT GCAGTATGCTTCTGAATCTAAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGC TTGTCTGTTTACCTGTTACGATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTA TTTCATCCAGGTCATGAAGGAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGA GACACAACCCATTGTTTATGGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGG TTATACCGCACCACCGTATGGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGT ACTGAAACATCGTCTTTACCCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCT TTTTGTTTCTAACTATAAACTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATA >In-frame_ENST00000406116_ENST00000579456_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=244AA_start in transcript=40_stop in transcript=774 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000225577_ENST00000393043_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=746nt_BP=162nt GGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCGAGACAGGGAAGCTGAGGAC ATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGGGGCTCTGCGAACATCAATA GATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTC TTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCT AAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTAC GATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAG GAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTAT GGTAATCTCTCTCTGTAACCTCAAAAAATTCATTAGACAAATATTTAATTACTTAGAGACTGTGCCTCAAAATAGAATACAACAAGCTTC >In-frame_ENST00000225577_ENST00000393043_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=208AA_start in transcript=21_stop in transcript=647 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000225577_ENST00000269122_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=3214nt_BP=162nt GGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCGAGACAGGGAAGCTGAGGAC ATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGGGGCTCTGCGAACATCAATA GATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTC TTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCT AAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTAC GATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAG GAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTAT GGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCGTAT GGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTTTAC CCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTATAAA CTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATTCAC TTGGGCTTTTTTTCTTCCCCCTCTTTCTTTAAAGAACTGCTCAATATTCAATCTGTTGTGAAGAACCTGATTTGCACTCTGTAGTGTTTA AAGAAACAAAGAAACTCTAATATTGAATCTCTTAAATTTAGTGTATGTAAACAGCTTACAAATACGTATTGTCTAAATGCATTTAAATCT GTTTTATTCAAAGAAAAGCTAAAGCAAAAACACTGGCATATGACCATGCAAGACTGTCAGTGCCAACAAAGACAACACTAATCAGCACAT CGTACACTGGATTGCAGTGCTTCCCAGATTATTGAAAAATGTTACAGACAACTTGCCTGATTTTTAAATGAGCGTAAAAGGCCCTCTAAC CTATGCAGGTTTCCCCATTATGCATATAGAAAATGCTAGTATGTTTTGCTCACTTCATATGTAACAGGTGCCCTTATGTTGTGCTGTATC CTGTGCTTTTTCTGTGGGACCATTCCATTCAGGAGCAAAGAGCACCATGATTCCAATCTTGTGTGTGTTTACTAACCCTTCCCTGAGGTT TGTGTATGTTGGATATTGTGGTGTTTTAGATCACTGAGTGTACAGAAGAGAGAAATTCAAACAAAATATTGCTGTTCTTCAGTTTTGTTT GTGGAATTTGAAATTACTCAAATTTAAAATAAATTACTGGACTGTGGAAATAACATAGAATTGAAGTTTTAATTAAATACCACTCAAACG AAAAGAACAGTAGTTTTTGTAGTTTTATATTGGATACTGAGGCATTAGGGAGGCATGAAAGGAAGAGGAATGAGGATTGAGACATGTGAA GACATTGTGCATTATATCAATGTGCATTCCTGTAGTTCATTAACAAGGTACATGCAATAGTCTAAAGAACCAGAGTCACTACTATAGTGG CTTAACATTTAATCTGTCTCCAATATTTTAACCAAGTGACACCGAGGTTTTTATCGAAGCATTTCACTTAAATGAACAAATCATGGCTGT TATATTAACTTGAAATAAAATATATTTAAACATGTAGTTAACATGCTCTTTCTCATCATGAATTATAAAGGTGCCCAAATTATGGGTATC TTGATTTTTTTCAAAAATTGGTTGTGTGAATCCAGCTCTTGCTTATGGCTGAGAATGTTCCTAAAGTTCATTTCACTATCCCTTAATCCT CAATAGCTACACATACCCCCTTGCCTAGTTAGTCTTGCACTGCTTTACAACTCTCTTAGGCAAATTACCTAACATAAGCTCCACAGAAGA GTTTTTTAAAACTTAAAATCCCTGTCCCACCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATTG CTTGAGGCCAGGAGTTCGAGACAAGCCTGACCAACATGGTGACTCCATCTCTACTAAAAATAAAAAATCAGCCAGGTGTGATGGTGGATG CCTATAAGATCCTAGCTGCTACTCAGGAGGCAGGAGGCTGAGGCATGAGAATCACTTGAACCTGTGAGGCAAAGGTTGTAGTGAGCCAAG ATCACGTCACTGCACTCCATCCTGGGTGACAGAATGAGACTCTTGTCTCAAAAAACAAAAAAACCTATTTAGTTTCATCCAGGACATTAA GTGAAAGTGTTTAATGTGAGTGCAGGTCAGTGAAGAATACAATGGTGCCCCTGCTTTGATTTGTGGGAGGTGCCATCAGTTTTCCCCACC ACTGCTTTTGCACCCTCAGTGCAAATATCAACACAGAGAAAAAAAAAATAATAATAGTATTATGAAAACATTGACTCTGTGGAGACCCTG TGGGTTCTGCAGAGTATACTTTGAAAACTATAAGATTATGAGTTCTATAAAATACCAAGTACAGATGAACTAGAAAACAAGCATATATCC ACAATTACCAGAATTTTCATAGTATTCCTTTTAGTAGATATGCCATGACAGTTACTTAGCCACCCCATGCCATCCTGTTGGGAATGCCAC TACCTTTGAATTTGGAGCCATCAGTCTATCTGAGGCAAACCTCAGAAATTACCTGAGCCAGAATCATGCACTTAGCACTGAGTTCAACTC AGTCTTAACGTTGCATTTTGTTGCATCACTTTTGCAGCCAGTAAACATTCTGTTTAGAAATAGTTGCTATTGTGGCATCATTCACAGTTG >In-frame_ENST00000225577_ENST00000269122_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=244AA_start in transcript=21_stop in transcript=755 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- >In-frame_ENST00000225577_ENST00000579456_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(transcript)=1018nt_BP=162nt GGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCGAGACAGGGAAGCTGAGGAC ATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGGGGCTCTGCGAACATCAATA GATGCTTATGACAACTTTGACAATATCTCGCTTGCTCAGCGTTTGGAAAAACATGAACTCATTGAGTTCAGGAGAATTGCTGCTTATCTC TTCAAAGGCAACAATCGCTGGAAACAGAGTGTAGAGCTGTGCAAGAAAGACAGCCTTTACAAGGATGCAATGCAGTATGCTTCTGAATCT AAAGATACTGAATTGGCTGAAGAACTCCTGCAGTGGTTTTTGCAGGAAGAAAAAAGAGAGTGCTTTGGAGCTTGTCTGTTTACCTGTTAC GATCTTTTAAGGCCAGATGTCGTCCTAGAAACTGCATGGAGGCACAATATCATGGATTTTGCCATGCCCTATTTCATCCAGGTCATGAAG GAGTACTTGACAAAGGTGGATAAATTAGATGCTTCAGAATCACTGAGAAAAGAAGAAGAACAAGCTACAGAGACACAACCCATTGTTTAT GGTCAGCCCCAGTTGATGCTGACAGCAGGACCCAGTGTTGCCGTCCCTCCCCAGGCACCTTTTGGTTATGGTTATACCGCACCACCGTAT GGACAGCCACAGCCTGGCTTTGGGTACAGCATGTGAGATGAAGCGCTGATCCTGTAGTCACCTATTTTCGTACTGAAACATCGTCTTTAC CCACTTCTCAGTTTATAATGGGGGAAAACAGGCAACGTGTTCTTGTAACCTTTATTTCATGAAGGACTTCTTTTTGTTTCTAACTATAAA CTTGGATCACCTATGTTAAAACCTTATTTCACATTCCACATCATTTTAGAATTTATTTTCGAAGGGGAATAGTTTCAATGTTTTATTCAC >In-frame_ENST00000225577_ENST00000579456_TCGA-BP-5198-01A_RPS6KB1_chr17_57970686_+_CLTC_chr17_57762417_length(amino acids)=244AA_start in transcript=21_stop in transcript=755 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRW KQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RPS6KB1-CLTC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RPS6KB1-CLTC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RPS6KB1-CLTC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RPS6KB1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | RPS6KB1 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Hgene | RPS6KB1 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| Hgene | RPS6KB1 | C0333641 | Atrophic | 1 | CTD_human |
| Hgene | RPS6KB1 | C2931673 | Ceroid lipofuscinosis, neuronal 1, infantile | 1 | CTD_human |
| Tgene | CLTC | C4518356 | MiT family translocation renal cell carcinoma | 2 | ORPHANET |
| Tgene | CLTC | C4693389 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 56 | 2 | GENOMICS_ENGLAND;UNIPROT |
| Tgene | CLTC | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Tgene | CLTC | C0334121 | Inflammatory Myofibroblastic Tumor | 1 | ORPHANET |
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