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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KC1-MT1G (FusionGDB2 ID:77618)

Fusion Gene Summary for RPS6KC1-MT1G

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KC1-MT1G
Fusion gene ID: 77618
HgeneTgene
Gene symbol

RPS6KC1

MT1G

Gene ID

26750

4495

Gene nameribosomal protein S6 kinase C1metallothionein 1G
SynonymsRPK118|RSKL1|S6K-delta-1|S6PKh1|humS6PKh1MT1|MT1K
Cytomap

1q32.3

16q13

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase delta-152 kDa ribosomal protein S6 kinaseSPHK1-binding proteinribosomal S6 kinase-like protein with two PSK domains 118 kDa proteinribosomal protein S6 kinase, 52kDa, polypeptide 1metallothionein-1GMT-1GMT-1KMT-IGmetallothionein-1Kmetallothionein-IG
Modification date2020032020200313
UniProtAcc.

P13640

Ensembl transtripts involved in fusion geneENST00000543470, ENST00000366960, 
ENST00000366959, ENST00000543354, 
ENST00000490299, 		ENST00000444837, 
ENST00000569500, ENST00000379811, 
ENST00000568675, 
Fusion gene scores* DoF score17 X 16 X 8=21767 X 7 X 3=147
# samples 177
** MAII scorelog2(17/2176*10)=-3.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KC1 [Title/Abstract] AND MT1G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KC1(213456619)-MT1G(56700882), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMT1G

GO:0045926

negative regulation of growth

18332874

TgeneMT1G

GO:0071294

cellular response to zinc ion

7559655


check buttonFusion gene breakpoints across RPS6KC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MT1G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA075655RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-


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Fusion Gene ORF analysis for RPS6KC1-MT1G

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000543470ENST00000444837RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000543470ENST00000569500RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000543470ENST00000379811RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3UTRENST00000543470ENST00000568675RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000366960ENST00000444837RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000366960ENST00000569500RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000366960ENST00000379811RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3UTRENST00000366960ENST00000568675RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000366959ENST00000444837RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000366959ENST00000569500RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000366959ENST00000379811RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3UTRENST00000366959ENST00000568675RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000543354ENST00000444837RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000543354ENST00000569500RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000543354ENST00000379811RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3UTRENST00000543354ENST00000568675RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000490299ENST00000444837RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000490299ENST00000569500RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3CDSENST00000490299ENST00000379811RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-
intron-3UTRENST00000490299ENST00000568675RPS6KC1chr1

213456619

+MT1Gchr16

56700882

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RPS6KC1-MT1G


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6KC1-MT1G


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MT1G

P13640

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RPS6KC1-MT1G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RPS6KC1-MT1G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KC1-MT1G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KC1-MT1G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMT1GC0014859Esophageal Neoplasms1CTD_human
TgeneMT1GC0546837Malignant neoplasm of esophagus1CTD_human