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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RRM2B-ZNF704 (FusionGDB2 ID:77854) |
Fusion Gene Summary for RRM2B-ZNF704 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RRM2B-ZNF704 | Fusion gene ID: 77854 | Hgene | Tgene | Gene symbol | RRM2B | ZNF704 | Gene ID | 50484 | 619279 |
| Gene name | ribonucleotide reductase regulatory TP53 inducible subunit M2B | zinc finger protein 704 | |
| Synonyms | MTDPS8A|MTDPS8B|P53R2 | Gig1 | |
| Cytomap | 8q22.3 | 8q21.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribonucleoside-diphosphate reductase subunit M2 BTP53-inducible ribonucleotide reductase M2 Bp53-inducible ribonucleotide reductase small subunit 2 homologp53-inducible ribonucleotide reductase small subunit 2 short form betap53-inducible ribonucleoti | zinc finger protein 704 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000251810, ENST00000395912, ENST00000519317, ENST00000519962, | ENST00000327835, ENST00000520336, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 5 X 5 X 4=100 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RRM2B [Title/Abstract] AND ZNF704 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RRM2B(103231042)-ZNF704(81555364), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across RRM2B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ZNF704 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-77-8009-01A | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| ChimerDB4 | LUSC | TCGA-77-8009 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| ChimerDB4 | LUSC | TCGA-77-8009-01A | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
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Fusion Gene ORF analysis for RRM2B-ZNF704 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000251810 | ENST00000327835 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| 5CDS-intron | ENST00000251810 | ENST00000520336 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| In-frame | ENST00000395912 | ENST00000327835 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| 5CDS-intron | ENST00000395912 | ENST00000520336 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| intron-3CDS | ENST00000519317 | ENST00000327835 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| intron-intron | ENST00000519317 | ENST00000520336 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| intron-3CDS | ENST00000519962 | ENST00000327835 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| intron-intron | ENST00000519962 | ENST00000520336 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000251810 | RRM2B | chr8 | 103231042 | - | ENST00000327835 | ZNF704 | chr8 | 81555364 | - | 14050 | 928 | 130 | 1134 | 334 |
| ENST00000395912 | RRM2B | chr8 | 103231042 | - | ENST00000327835 | ZNF704 | chr8 | 81555364 | - | 13650 | 528 | 0 | 734 | 244 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000251810 | ENST00000327835 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - | 0.000967924 | 0.99903214 |
| ENST00000395912 | ENST00000327835 | RRM2B | chr8 | 103231042 | - | ZNF704 | chr8 | 81555364 | - | 0.000693545 | 0.99930644 |
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Fusion Genomic Features for RRM2B-ZNF704 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RRM2B-ZNF704 |
| Go to FGviewer for the breakpoints of chr8:103231042-chr8:81555364 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZNF704 | chr8:103231042 | chr8:81555364 | ENST00000327835 | 6 | 9 | 383_387 | 344.0 | 413.0 | Motif | CR1 | |
| Tgene | ZNF704 | chr8:103231042 | chr8:81555364 | ENST00000327835 | 6 | 9 | 401_405 | 344.0 | 413.0 | Motif | CR2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZNF704 | chr8:103231042 | chr8:81555364 | ENST00000327835 | 6 | 9 | 318_412 | 344.0 | 413.0 | Region | Sufficient for binding to RE2 sequence motifs | |
| Tgene | ZNF704 | chr8:103231042 | chr8:81555364 | ENST00000327835 | 6 | 9 | 193_218 | 344.0 | 413.0 | Zinc finger | C2H2-type |
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Fusion Gene Sequence for RRM2B-ZNF704 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000251810_ENST00000327835_TCGA-77-8009-01A_RRM2B_chr8_103231042_-_ZNF704_chr8_81555364_length(transcript)=14050nt_BP=928nt GGCTGGCCGAAGTTAGGCGGAGCCCCGAGGCGGGGGAGGCGGGGCCGGGCCGGCGCAGGGAGAGTCACTCAATGGACAGGCGAGAAAGCA GGACCGGCGCGGCGGGGCGGGGCCGGCCGAGTCCCTAGAGCTGGGGGCGGGGCGGACCCAGCGGACCAGCGGACCACCTGGGTGCTGTCG TAGTTGGAGGTGGCCTGAGGAGCTCAGTTCCCTCAGCGCCCGTAGCTTCGGCGGAGTCTGCGCGATGGGCGACCCGGAAAGGCCGGAAGC GGCCGGGCTGGATCAGGATGAGAGATCATCTTCAGACACCAACGAAAGTGAAATAAAGTCAAATGAAGAGCCACTCCTAAGAAAGAGTTC TCGCCGGTTTGTCATCTTTCCAATCCAGTACCCTGATATTTGGAAAATGTATAAACAGGCACAGGCTTCCTTCTGGACAGCAGAAGAGGT CGACTTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAAGCAGATGAGAAGTACTTCATCTCTCACATCTTAGCCTTTTTTGCAGCCAG TGATGGAATTGTAAATGAAAATTTGGTGGAGCGCTTTAGTCAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATTCT CATCGAGAATGTTCACTCAGAGATGTACAGTTTGCTGATAGACACTTACATCAGAGATCCCAAGAAAAGGGAATTTTTATTTAATGCAAT TGAAACCATGCCCTATGTTAAGAAAAAAGCAGATTGGGCCTTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTGGC CTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTTGCTGCTATATTCTGGCTAAAGAAGAGAGGTCTTATGCCAGGACTCACTTT TTCCAATGAACTCATCAGCAGAGATGAAGTGTCACCCACACATCATCCGGTGGGCACAGGAGAGCAGAGACAGCATGCGCACACGGTCCT GTCCTCCCCACCCAGAGGCACAGTCAGCTTAAGGAAGCCCAGGGGAGAGGGCAAAAAGTGTCGGAAGGTGTACGGGATGGAGAACCGAGA CATGTGGTGTACCGCCTGCCGCTGGAAGAAGGCCTGCCAGAGGTTCCTCGACTGAGAGACCCCCAGGCAGAGGGGCTCAGGGCCCTGAGC CGCTCCTGCCCTGGCCTGCCACTGCAGGTGTTGGAAAGAGCTTTTCCTACTGAATAAAACACAGTTGAAGCCAGGAAAAGCCCTTTCAGG AACCTTGGAGGAATAACAGCAAAAACACAGAAAAATTGTTTAAGTCACCACCTATGACAAAAGAAAGTTGCTCTTACTGAGAACCCAGCT TGGAGCAGCTATAACTAGTTTTTTTTCCTTCAAAAGAAAAGTCAACTTTTTTTGCTGTATGTCTAGACTTAAAACTGTGGACTTCTGTAG CAATTGAACCAACAAAGCCCATTTTACCTAGAAAGGAGGCATATTTTGATAAGCTTTCTGAATTATGCCATTTTCAAGATTTTTTTGACA CTTAAAAAACAAGCTACAGGTTATTCAGTAGCATTTGTACAAAGATCAATACTTACTTTTGTTGTGAATAATCTTTTCCGTATCTTCCAT TTGACTTCTTGGAGCAGTATATGTCAGGATGTGTTGCAAGACAGCGCAGCACTCTGGGCATCTTTTCTATGGCTTTTTGTTTGTTTTTCT TTTAAGAATGGCCCCACACTGAACCATGGTAGAGCTATTAGTTTGTAGGGCCCCAGATGGCATAAACTCGAGAAGGGATTGTCCACGGAA ATCACCAGCAGACTTCAGCCCGAAGCTGAGTTCAGGAAGTCCAGCTGTCACTGTTGGGAAACATCTAGGAGTCTTCCTTGGATCCATAAG AAGCTCTTCCCCTAAAGGCAGCACAGCTAACTCTACTCTCTACCTGCCACAACTCAGTCAAGAATTGGCACCTGTAGCCATCTGGGTAAG CCTCGATGCTTCTTTCAGGGATGTGACACAAATGGCAACTCGGAGCTATTTGTTACTGCTTGTCTGTCAAGATTGTAGCCAGGTTAATGG GTCATTTTCCTTCTCTCCAGACTCCACCACTGACTGATTTCAGAAGAGGTAGAGAACTCCAAACTGTCCCAGCAGGTTTGCTTTAGACAA CAGAGCACAGCCCACATGGCCCTACCTGTTCAGAAAGTCATGTTAGATCAACAAACCACTTCCATTCTGAGTGCACTTTTATAGGTTTTA TGCTTTAGCATGTCCGGGAGATGAGTTAATTAACAATATAAACATTATGTGAGTAAATGGAAGGTCCAAACTTTAAGTTTTTCTTATAAA AATATTGGAGCTATTCATTTAAGAATTTGCTCAAAAGGGAACATAACGCCAAAAGGAAAATGCATGTAGGTATAGGAATTTCTCAGTTTA GTAGGGCCAGGGCTTGCACTATGTTCCATTTATTGGGCTTCGTAACTTACTTGCTTGTTTGTTTGGGGGATAGTGGTGTGGGGAGAGGGG AGTCGTCAAGCCCTATAAATAAGCTCATTCTCTATCTACCCGACTCTCAATTGCCCTGCTAAAGAGTTATTTCTCCTATACCTATGCAAA GTAGGAAGAGCACCTTATAGGAGGCACTGTATAGGGACAGGGGACATGGGATCAGCCATAGGAATGTTAAATGAAATTGCACAGAGGAAA GTTTAATATATGTCTAGAGATTATACATACACTTTTTTAAGCGTAAAAAGAAGACATCTAGTAATGACAGATATTCTTTTTATATACAAG CAAAAGAAAGTATAAGGAGGTTCTACAGTGCAACATCCACAATCTGTGCATTCACATATTATGGGACTTTTATTTTTTAAACTCTCATAT AAATTTTTTAAAATTACTCCTTGGAAGAGATCCTGGTTTTTTTCTTCATTTATTTTTTTCTTTAAAAACATTTATTTTAAGAGAAGAGAA AAAGAGCTTCATCTAATTTTGCATCTTGATTACCAATCAGTACTAGTCACAGCACCAGCAATACTGTATGTTTTAGACTGACAAGGTCAG CCAGGAAATGGCATTTTTTTAAACGCAGAAATGTGTTTGTTTCCTCTACTCTAACACGTCCTTTCTCCTCCTGGTGTCCTGTCACCCCCC ATGCAGCACCACTGATGCGAGATGATGCTCTGGCCTGGTCCAGGAAGCCCTGAGCCATGGGCAGATTGCCCAGTGGCCTTGGGCGGCCAG AGCTTGTCACCTGTTTAAACAAGTTCACCATGTGTTTAAATGACAGGGTACAGTCCTGGACCAGAGGTTTTTCTCTTCAGCAAAGCTCCC TGGCCCTTGATCGTTGGACTGTTACTAATAGAAAAAGATTCAAGTCATGAAGTATAAAATCCATCCCCCATCCCAGAACTTTGAAACACA AGGAGGGAGAGATCTTTGCTATGGAGCAGTCCTGGAGCAAAGCCCCGTGGCTTCCACCCCCAGATATATACCCCATAAGTAGTGCTGAGC TCCAGCTTAGCTGAGCCAAGCTCAGTCCTTATCTGGTGTTCAGCCAGTGCACAGGTATAAGCAGAACTACAGAGCTGAATGTAGCTTCCC TGGGATCTCTTCTCCTTTCTAAAGCATTTTTCACACAGTTCTGTACCTCCTACCCAAGTTGGGGCTGCTTTCTGCCTGCTAGCCCACGGC TCTGTGTACTTTCTTTTCTGGCTTCAGGTGCAGACAGACCCTCAGTACCTTCCTGGACACAGACACATATTCCCTGGACCAAGGCGTGGA ATAACTAGTAGACCACCAAGCCACAGGTGGCTGGTCTTGAAGAAAAGGGATTATACTCCTTACAGGCCACCCAGAAAGCTATGAATTCCA ATATACACCACTGATCGTGCAAGTTAGGGTTTTTTTTTTTTAAACGTAGCATTATTTTGTTATATTTTGGAACTAAATGAAGTGCCAAAT TAACCAGACATTCGTTTGATGCCATCTCTGTGGAACCAAGTTCTCTGTGTGTGTTCGTTTGGCTGGGAGGAGGGGGAGGACTGGGCAGAC TGCTCCCACAGCAGGCTGGCAGTGGAACTGGAGCCCTGGCCACCGCAGGGAGCTCAGAGGCCAATCTACGCAAAAGGCATGCAAAACAAT GGATTCTGGTCCCAAAATATTTCTAAGTAAGGCATGATGTAGCCTTTTGATTTTTTTTTTATCCTTTGACACCCCAGCCTTCAGAAAAGG TTTTTCATCTCTCTCCAAAGAAGTCATTTCATAGTGACTGACAGGACATTCTCCAGAGAGCGACAAAGCAGAGTGGCCAGCAGGCAGTGG TGTTAAGCCTTGGGCCTTCCCAGCAGATGTGTGCTGCATTGGTGGGTGGGAGGCAGTGTGACAGCCTGGAGAAAACACACAGGTAGCAAG GGAGTCAGGGGGGAGGTACAAGAGGGCTGTGGACACCTGGCTCTTGCTCATCTTCTTGGTGCTGATCAGCTGGTGGTCACCATCCCTAAG TACCTCCCAGGGAGCTGCCATTTTCTCCTCTGGGAGCAGCTGCCTGAAGCAAGGAGAGAATGACCTGAAGGGAAGTACCTCCGGCCAAGA GTGCAGGGCTGCTGTGCCTAGCCTGAGCGGGCCATCTCTAGCAGATATGGACTTCTCTCCACCACACTAGCTGAAAAGTTTTCTCCCTTG GTTGGCAAAAGCCAGTGTCAGGAAAAAAGCTGTGGGTTTCTGACCAAGAATGTGTGCGCTTAGCTGCAAAGTGCCTGTCAGCAGCTCCAG GCACCAACAAGGTGCCCTTTTATTAGACAATTCCTGCCCGAACATAACCATATTGCAGATGAAAATTTTCAATAGAGAATGACACAATTC TTGACCTTTCTAAAAACTTTTCAAAGAGATAGTCACATGTGTATATGTTGCAAAAGATTTTTGAAACTGAAATGTCCTCCATTAAATCTC AAGAGCACTCGAGTTTTAAGTCTGCTGTTTCTGGTGTCACACTAAGACACACTTTTGAAAGCAGCCCTGGGTTCTGAATTAGTTGGCACT GCTGAATCCATGTTCCCCCTTCATCAGACTCCAAAGTGCAGCATTCACTTGCAAAGGTTGAGAGAAAAGTGGCCAGAATTGTACATATAA CAGAGAATACCTTGAGAATAGTAGCAAAATACTGTAAATAATATTCATTTCCTCAGGGAAAAATAAAGGGCATGCAAAAATAGGTCTGGA GACTCCTGAAACTAGGAAGAATTTTGTTATCACTAAAGTCTTTTATAGTCAGAACAATTTTTTTTTCAAATGAACATGGTATCATTTCAA GACAAATTTATGTGAACTGGGCAGTACTGACATTTGTGAGGCATAGGGGAGTGCCCTGGGAAAACGGTTTGGAGCTGACCTGTAGCCTAA GGCTAACATTTGAACCACAGGTGCAATGCCTGGGGGTGGGGGAGGGGGACGGGGTGGGGGTGGTATTCCTAGACTCACGTAAGGCTTTTT CTGAATGTAATTGTGAATACAAAGCCTTGCTGGTCCTTTTTATCATTACCCAATGGATGACTGTTTATTAGCTATCAGCAGAATTCCGTA GGCGAAAGCAAGCCGTGAACGATGTACATTTTGCTTTAATAGCATGTTAGCGAACAAACTTCCATGGACTTTTGTGGACAAGGTGCTGCT TTTTCTCATGACCCTGTAGAATTGCTATCGACCACATCTTCTGTAGCACTGACCTGTGTGAACTCAGGGAAGAATTTGTGCATACAAATG AGTGGAAACAGAGCAGGATTCATGAATATGAATGAGAATGTGAATCATTTTGGAGAATGCCCTGGGCACACGGGTCAACTGGAAATTTCA TTTCTCTAAGAAAGTAGCCCTACCAGCGGCACGGACTGTTCCTGTTCCTCATACCTGTGGGGATTCCTCCATATTGGAACTGTTTCATGT ATCTTTTTTGCATTGTAACTAGCCAAACCTGAAGTCAGTAAATAAAATGAGATTAGCACTTTTTTTAGGTACCAGTTGTATCACTGAGTA ATGCACACCAATAGAGCAAGAAAGTATAAAATGTATTTAAGACCAACTGGTTTGCTTATTATGACTGACTTTGAAAAAGCCCATATCCAA TGATATACATGCTTTAAAAGGTATATCTATCGTAGGACCAGGAACCAAAATGGGAATTTTACTTCTGGTCCTGTTTTGTAAATAGTTCCT TTTTTTGAAGACAATCTCATGTTTTATAACTTTTGTTGTGGGTCTGAGAATCACAATGGTAATATGTCTTGGCAAAACATAACCTTTAAA TACAAAAACAATTATAACTTAATTTTCCAAATAAAACAAGAAATACACTGATTAGGCTTCTACAGTTCTAAGAGACATGACACTTTGGTA ATAAGCGTCAGTACTCTACTTCTCAAGTTAACTGGAAATATTTTACAAGATGCAGTGTTTTGTAATCACAAAGAACGCAGACATTTTGTG AGAAATGACCTTGGTTTTATACATTGTAGCTTATTTTTTAAAATATAGTATTTTACCAGGCAGGAAGTATTAATATTATAAGTAATTCTT GCTCACCAAACAAAGGGCTATGTCTCTTTTAAGCAAATGTTTTGATGCATATCTTTTTAATTAACCCTCTGCAGCAAGGGTAGAAATACA GATCAGATGGAATGGGTATTATAGGAGAATCAAGATAGCAACAGCTACTCCTTTTACCATTACTAGTGTGTTTTCAAAGTATGGAAAAAG ATGCCTGAAGAGTCATTTTATATATTTTAAATCTAAAAAGTGTTAACAGGTATGCTTATAGGCCATGGGAGAAATATTCTTATAAATTTT TTAGTGTAAAATGATAAATTCTGTGTCACAAAGACAAGTTTACCACTTGACCTACCAGAATCACAGATACTTGCATTTAACTAGCAAGTA TCATTTGGTGGAAATTTCTAAAATCATAGTAGACAGGCCCAAAGATAGAATTCTTAGGTGATCAGTAGTGTTTAAAATAATTTTGTCCTC AGCACTAACTATATAACTGTAATTTCTACATAAGAACAAGTGCTTCCAAAATATAGTGGAGGGAAAAAATAAAAAAGGAAAATAAAAAAA CAAAACAAAAAGAACAAGTGCTTGATTTTTCACTGTGAAGAACTAGCAGGCACATGAGGTTGTGATCAGAAAGTGACTGAGTTCCCAAGA ACCAGGAAACAGAGGGGAGTTGTGAAGAGTTTATTAAAACTGTACAAATAATTCAGAGCTTTGCCAAAACCATTTCATAATGCTGTACAG TTTTTTCAAGCCCACTCACTGTTAAAACAAGAAAGCACCTTTTCTTTCTAAGATTTTAGTAATCCAAAAGCTAGCCTAATTAGCCAAGTA TGCAGATAACATCAAAAGCAAAGCTGAGATAGAACAGCCATACACCCGTTGGGCAGCTCTTATGAGGTGGTCAGAAGGTCACTCAGACCT TGGTTTCAAATAGGCTTTAGAATCTGCACACTTGAGGACTAGAAATGCACAGAGTTAGGGAAAGCCATGTACAGGCTTGGCTCCTAGTCT TTGAGATGAGGCGTCTTGCAAATCTCTGTTTTCACTCCTTGGAATGTCTCCATTGTTAGCATTAAAGTCCCCAAGAAGTTTTTATTGCTG TACGGTTTTGAACCCAATGAGTCTCATTTCCAAAAGATTCCTAATTCTATATAGGAGAGGTTGCAAATGTCAGTGCCTCAGAAGGACCAG GCAAGTTCTGTAAATGATTGATGTGGATAAGGCAAAGAGGAACACAAGAATGGTGGAGACCAGGTTGAACTGCAGAACACATGCCCTCTT TGAAGGGGTGCCCACACTCAGCTCTAGACAATCAGAACCATGCAGAAATCAGGCCCAGGGCTGCTAGATCTTCTGACGTGGAAGTATGAT ATTACCTGACACGTAAGTGTTGACAACTAACTCAAACTCTTGGCCAACACTGTGCAGACCAAAGAGAAGCTGTACACAGACAGGTGCAGC CTGCAGCCCCCAGTTTCAACTATTGGGAAAAGTGGATTTCACATTCCACAGTTGTCAGGTCAGGTTCATCCATCAGCCCCACAAACTCAC ATGTCGGCACTATCTGGGCAACTAAAATAAAAGAGGGGAAAGAGATCATTTCTCCCCAGATATCATTCTCATGGCAGACTTGAATATAGA TACGCTGAGTTATCCAGCTCTCTCACTCTGCCTCCTTTTGGCATGCCCAGGCTGTGCCCCGTAAAGTGTTGAATCACTGTTATCCTAATT TTCTTAGTGTTTTCTACCGTGGCCACTGTGATGAGGGGCTGGCAAAGAGCAGCCTCGTGCCTTCCGAGAAGGCTGCCAGGAGCCTCTGAA GCTTGAAGCGAGCACACATTGCCTCCTTGTGCCAAAGCCCTTGGCCAGCCTCCCCACACTCCTTCCCTCTCCATCCGGCCTCATGAGTCT TCGTTACCAAGTAAAATTACCACTGCTTCACCTCTGATACAGCAGAAGCCTTGCTTCAGAACTGGTAGGCATTTAGGCTATTTCAGAGTG TCCACTAACCTCAAAAGGAGGTTTTTCCACATACAAAACCCTAGCATCTTTGAGGGGAAAGCAAAATGAGAATAAATTATGTCATGAAAA AAATTAGAAGTTGCTTCCTTCATTTAGATGGACTAAGTTATTTTAAACTCTATCTTACATCAGAGTCCTGATGGTGTTGGGATAGTCACT GACCCTTTCACGTATGTAATAAGATACGTCTCGTTCACACACTATTTCATTTGATCTTTGTAAGAACCCAGTGTAGAATAGGAATATTTA AAATCAACATTACCCACCTCCAAGGCCAACCCAGAGTAGTCTTGAACCTGAGTCAGCCTCAGTATTGCTTGCAAGGAAGAGGGAAGGGGC TCATTAAAGGCCTGGCTCAAACCTTAGTCTTCCAGACTGACTAGGGACGTAAGAAGACCCAGGGACCCACCATGTTCTCAAACCATCTAT TCAGTCCAGGCCTTTCAGCATAGACATAAAGAGCCCACCCGTTACTCAGTCATGTTGCCAAGTGCAAACTGATTTATCCCCAGATGAATC CCTTTACTGTAGCAGATCCCTAATCCCTAAATTTCAGCCAATTTGGTAGTTAATTATAGGAGTTTATTAGCTAAATGTATGTTCTGAGTA AAAGTTTTGACTCTTTGGGGAAAATTTATTTTGCTGCTAGCATACAACATTTGCTATGTATATAAACTTAAGTCAATGCCAGAAATTTTA AAACCAGCTCAAATTTATAATCTGTAATGATCAAATCAAAACATACTGTAAACTCAGAGTTGGAAACGCCTGGTAATATGGTTAAGTCAT GTTTAAATATGAATGCAATTTAAATGACATTGGCAATGCCTGAGATTTCTTTCATTGTGAATGATTAAAAGGCAGTCCAATATATGAATG GATTTCATCTTACCTTTCTCCCGTTAATTTACTAGGTGTAACATCTTGAGTGTAAAGTCATTCACAGGCAGTTGGGTTGTGGAGCTAGAA GGAGCCTCAAAAAAAAACTTTTTGGCCAGACTCCTACATCATGAACAGGGTTTTTGATGAATAATATTTATTATTATGTTTCTAAAGTAA TACAGTGTTGGAGAATGAAACAGTTTAGTCCTTTCCTCTTCTGATGGAAAAGAATCATAGCGCCGTTGCCATGACAATAACAGGATGTAG AAAGACCCATGAAGAAAGAAAGAAGAAAGCTATGGTTCCGAAAGCAGGTAACCACAGATTTTGAAAGGAGGCAGAGATGGTGATTAAACT GTAGTCCTTGTTTTTTAAAATGTTCTTTCATGTTAGGCACCACCACATAGTTAATAACTACCAACTTCTAAAGAGAAGATCCCCTTGATT TATTTATATCATGAAAATACTAAAAATCAATTCTCAAGTCTAATTAACTATTACATTATCTTGCTAGGTCCTTTTCCCTAAATTTTTAAT TCAGAAAATTAACCAGAATTGGCCAGATGCAGTGGTTCACGCCTATAATCCCAGCACTTTGGGAGTCCAAGGCAGATGGATCACTTGAGG TCAGTAGTTCAAGACCAGCCTGGCCAACAGAGGAAGAAAGAGTGAAAACAAAAGAAGAAAGAGGGAAACCCTGTCTTTACTAAAAATACA AAAATTAGTCGGGCGTGGTGGCGCACACCTGTAATTCCAGCTACTTGAGAGGCTGAGGCAGGAGAATCCCTTGAAACTGCAGGCAGAGGT TGCAGTGAGCCAAGATTTCACTGCTGCACCTGGGGTGAGACTACCATTAAGGAAGGAAATTTCCTTTAAACAGAAAAAAACAAAGGTGCT CATCTATTTCTTCTGAATTCTCTCTACATCCTTGACTTAAGAGGAAAACCAGCACTCAAGAAACAGCTTTAAAAGAGAACAGTCCCCATT CTAGCTACCAGTCTTGCTTTCCCCCATCTTGGCAAGCCCCAGTGAATTTGCCATTGAAAGATTACCCTCCCCTTTGCCCTCATCTGCCTG AGCTAGAGGCCAGGCTGTTGTTAATGTTTTTTCAGTTCCAAAGCCCCTGATGGGACATTCTTGTTTCTGTGCTACTGCTTTCTCTCTCTT AAATTAAGGTGCAAGGGGATAAATATTACTATAACTGGGATGTAAGGCTCAGTCAGTGTGGCTATTCCCTCCCTTCGGGGGAAATATTCC ATCTGTCTGAACGGTTTTAGGTGATCATGAGGAGAGCGGCTTAGTCACACAGCCAGCCACGCTCATCACAAAAGATTTGTTCAGACTCAC TGTAAAGAATGACAAGGCAGATAGCTAATCCTTTCACTGTGCCTCAAAGCCCGCCGTGCAAGTCACCAACCCTACCGGTCCTCTCCACGT GCGAGGCTAATAGAGTGATCAGAACCAGGAATGTGAGCTGGGTTCCACCTTAGGAGGGGACAATGAGGACAGAGCAAGAGGGCTCCATGT TTAATTACTCCAGGCTCTGACTTCTGCCCACAATTACAGAGCATGAAAGCAGAATTGGCCTTTAGTAAGTGAAAAGGAAGTGGCTCCTGC AGCATATAATTGTTATAATTTCGTATTTATGGAAAGAGAAAAGGACTTCAGTCCACTCATGTTGTTAAGCACTTGTCCCTCACTCCACTG GAGCCCCCTTCCTATGTTTTGGGCACAGATGGCTGGGACCGAGAGGAAAGAGGAAGAGCGGCTGCCAGAGTGTGAATATACCCCTCAGGG ATATACAGCGGAGTTTCATGATAAACTACCCATACTTTCCCAAAAAAGGTTGAGGAGCAATACATAACTTTGCAGATTACAAACCCTTGT TTTACTTTTTAAACCTTTTTTCCATACTCTGCTTATTGGAAATCGATGGCTGTGATGTGACCAACACCTGTGATGATAGCAAAGCCCCTC CTTTCACAGTCTCCTGACTGTTCGGGGAACCTCCTTGGTCATTGGTAGAAAGCTTTAGAAAAGACTTAGCTTTTTAGGGAAGAACTAAAA AATCTCCAAAACATACTAGTCCCATGACTTCGATAACTGAAAATGTCCTGGGTGTAAACTAACCCAGGAATGTGGATCATACATGTTTTT TTTAAAAAAAATCCCTGAATCAATATTTTCCTACAACACACCCTAAAATTCCTATTTTTGTAATTAATGGTTGGACAGTGATCAGCCATT TAAACATAGGCTTTCTGGAATAACCAGACACTAGAATAGTTTCCAAAGTGTTTTGCGTATCAAAATCCTATATACTTAGAAGAAGAACTC AGGATAAGAAAAAATCGCTAGGTCCCAAAGGGTTCATGACTATCATCAGATGCAACTGCGAGTGGCCTACGGTCATTTTTTCAAATGAGA AGACTGGAGAGAGAGAACAACAGTAATCACAAAACCTCTGTTGCCCTTAGTCCATGACAATGTTTAAGGAAACTTTAAAAAATTAAGCCA TCTTCTGAATTGTTTTCTACACCAAATCTAAAATATTAAAATGAAATTATTAAATATTTAAAATGGGGTATTTAGTGGAAATGCAATCAG TAGAAAACATTGCTTTTTAGTGCCTGCTAAACAAGTAAAGGAGAAAGAATGAAGAGAAAACAGCAGTCCTTCCTGTGTGACACTCGTGTG GAAATGACAGGCATTCACATGTCATTGAGTGCTAACTCAAAAGCTAGGTGGCAATGCTGTCCAATGTTTAGAGATCTTTTGAAATATAAT TTTACCACCATTCAGAGGTAAGTACTTGCTTAACAGAAGTCTTTAATGTTAGTGAATGAATGTATAAAATTATAAACTATGCATTTTCAA AGAGTAGCATGTATTTTGTATCGAATCCAAGTAAATTTTTTTCATAGCTACCTACCACAACTGCAAATTATTCAAAATAAACTTGGATAC ATATCCTTATGGGGATATGGGAAGCCCATCTATATTCTCCTACTTGATGTTTTTAAAGATTGAAACTTTATTCTGAAACATCAGGCTCTA AAAAATTCCATCATTAAGATGAATAAATGGGAAATGGTTTATTTGTTACTTCGTAAGCATAAATGGGAAATGTTGGCTGTTAGAAAATGT GCCCAGTTCTTTAAAGGTGGATGTTCTAGTAACACTGGATTAACAAGCAAACAAAACTGCATGAAGTGAACGAATATTTCATTGGATAAA GTTAGCATAGGTTTTATCTGCTGGGTTTAATTCTCAATCCCAGAAAAAAATATTCTTCAAGGGGTATCAGTTATAGTTTCAAAGAACAAA ATATGAAAATATTGTCCAGCAAAGCAAATCATTGATCTTTTTTCAAAATTACTTATATTTTGGAAAGTCTATATAGAATATCCACAAATT TCTTCAGCCCTCTTGTTGATTTCATATTTTCATGAAACTTTTTCCCCTAATAATTTGTCTTCGCTCTTTAATCAGTGCTTTACTACATTA CTCAGCCTGAAAAAATATCTTTTCCTTCATCTGACAATGTGGAAATAAAGAACTCCATTTCTGTCATTCTGGTTCTCTTCAGTGTCCATT GAGAAAGTTTCTCAACTGTTTGTAAAATACGGGGGGAAAAAAACACGCATTTCTAAACCTGGTACTTAAGGTTATACTGGATTGTTTGCT ACCTAATTAGAAGTTATTGGGGAAGGGGCATTGTGTCTTTTTATATGATTTTTAGCCAAATCCAGATGTTCTGATACACATTTCTGAATA CCTGTCTGACTGTAAATACAGCCTGTGGAGGTTCAGGTTGATAAACCTTTCACCTGACTGCTCCACAGCCATGCTCCTTGCCAGCTTCTG GCACATTGTACATAGATTTGTTGAATGTTTAAATGATGTTGTTTTTCTAAATGCTGTTCTCTAAAACAATTTTTTGAATTTCTTTTGCTT TCCATTGTTTTGGACTTTGTGTGTTCGTTTTTTAAAAAAAAAAATGTTTCCTAAATATTTAACACCAGGAAAAATATTTTTAAATACACT GGTGCTAATTGAAACAGAAGGAAATTTTCAGATCGAAGATGTACAATGTTAAATGTTCATACCAGTTAAACTGCACTTTCCCAAGGGGAC AGCTGGCATCTACTTGAAATGGGCATCAAGAGACCACCAAATGTTTACAGTTTCTGTGGCCCGTTTAAGTGTAAAATGCAGAAGTGGCTC TGTCCCCCCAGAGTTAAGGATTTGCTACACTGGTCCTCTGGAAGCATTTAAGTAGAAGAAAAGGCTTATAGTCAGAATCACTTTAGTAAT CGTCTTCTGGTCCTTGGACTTTTCTGTTCTGTAATGCTTGTAACAATGAATATGGTGTTGCCAATCTAGTCTGATATCATTGTTGACCTG TACTTACTTTGTGGATGGTTCTACCTGGGGTTGCACTGGCACAAACAGAGCCAGAACACTGGACTTTCAAAAGACCATTTTGACTTCTAC AGTGTCCACACACATGAATTTAAATGCACTTGTAACTGGTTAATTACCATGAAGTAAGTCTAACTTCCACTTAATAAAAGTTTTTGTGTA >In-frame_ENST00000251810_ENST00000327835_TCGA-77-8009-01A_RRM2B_chr8_103231042_-_ZNF704_chr8_81555364_length(amino acids)=334AA_start in transcript=130_stop in transcript=1134 MGAGRTQRTSGPPGCCRSWRWPEELSSLSARSFGGVCAMGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDI WKMYKQAQASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLI DTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEVSPT -------------------------------------------------------------- >In-frame_ENST00000395912_ENST00000327835_TCGA-77-8009-01A_RRM2B_chr8_103231042_-_ZNF704_chr8_81555364_length(transcript)=13650nt_BP=528nt ATGGGCGACCCGGAAAGGCCGGAAGCGGCCGGGCTGGATCAGGATGAGGTCGACTTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAA GCAGATGAGAAGTACTTCATCTCTCACATCTTAGCCTTTTTTGCAGCCAGTGATGGAATTGTAAATGAAAATTTGGTGGAGCGCTTTAGT CAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATTCTCATCGAGAATGTTCACTCAGAGATGTACAGTTTGCTGATA GACACTTACATCAGAGATCCCAAGAAAAGGGAATTTTTATTTAATGCAATTGAAACCATGCCCTATGTTAAGAAAAAAGCAGATTGGGCC TTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTGGCCTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTT GCTGCTATATTCTGGCTAAAGAAGAGAGGTCTTATGCCAGGACTCACTTTTTCCAATGAACTCATCAGCAGAGATGAAGTGTCACCCACA CATCATCCGGTGGGCACAGGAGAGCAGAGACAGCATGCGCACACGGTCCTGTCCTCCCCACCCAGAGGCACAGTCAGCTTAAGGAAGCCC AGGGGAGAGGGCAAAAAGTGTCGGAAGGTGTACGGGATGGAGAACCGAGACATGTGGTGTACCGCCTGCCGCTGGAAGAAGGCCTGCCAG AGGTTCCTCGACTGAGAGACCCCCAGGCAGAGGGGCTCAGGGCCCTGAGCCGCTCCTGCCCTGGCCTGCCACTGCAGGTGTTGGAAAGAG CTTTTCCTACTGAATAAAACACAGTTGAAGCCAGGAAAAGCCCTTTCAGGAACCTTGGAGGAATAACAGCAAAAACACAGAAAAATTGTT TAAGTCACCACCTATGACAAAAGAAAGTTGCTCTTACTGAGAACCCAGCTTGGAGCAGCTATAACTAGTTTTTTTTCCTTCAAAAGAAAA GTCAACTTTTTTTGCTGTATGTCTAGACTTAAAACTGTGGACTTCTGTAGCAATTGAACCAACAAAGCCCATTTTACCTAGAAAGGAGGC ATATTTTGATAAGCTTTCTGAATTATGCCATTTTCAAGATTTTTTTGACACTTAAAAAACAAGCTACAGGTTATTCAGTAGCATTTGTAC AAAGATCAATACTTACTTTTGTTGTGAATAATCTTTTCCGTATCTTCCATTTGACTTCTTGGAGCAGTATATGTCAGGATGTGTTGCAAG ACAGCGCAGCACTCTGGGCATCTTTTCTATGGCTTTTTGTTTGTTTTTCTTTTAAGAATGGCCCCACACTGAACCATGGTAGAGCTATTA GTTTGTAGGGCCCCAGATGGCATAAACTCGAGAAGGGATTGTCCACGGAAATCACCAGCAGACTTCAGCCCGAAGCTGAGTTCAGGAAGT CCAGCTGTCACTGTTGGGAAACATCTAGGAGTCTTCCTTGGATCCATAAGAAGCTCTTCCCCTAAAGGCAGCACAGCTAACTCTACTCTC TACCTGCCACAACTCAGTCAAGAATTGGCACCTGTAGCCATCTGGGTAAGCCTCGATGCTTCTTTCAGGGATGTGACACAAATGGCAACT CGGAGCTATTTGTTACTGCTTGTCTGTCAAGATTGTAGCCAGGTTAATGGGTCATTTTCCTTCTCTCCAGACTCCACCACTGACTGATTT CAGAAGAGGTAGAGAACTCCAAACTGTCCCAGCAGGTTTGCTTTAGACAACAGAGCACAGCCCACATGGCCCTACCTGTTCAGAAAGTCA TGTTAGATCAACAAACCACTTCCATTCTGAGTGCACTTTTATAGGTTTTATGCTTTAGCATGTCCGGGAGATGAGTTAATTAACAATATA AACATTATGTGAGTAAATGGAAGGTCCAAACTTTAAGTTTTTCTTATAAAAATATTGGAGCTATTCATTTAAGAATTTGCTCAAAAGGGA ACATAACGCCAAAAGGAAAATGCATGTAGGTATAGGAATTTCTCAGTTTAGTAGGGCCAGGGCTTGCACTATGTTCCATTTATTGGGCTT CGTAACTTACTTGCTTGTTTGTTTGGGGGATAGTGGTGTGGGGAGAGGGGAGTCGTCAAGCCCTATAAATAAGCTCATTCTCTATCTACC CGACTCTCAATTGCCCTGCTAAAGAGTTATTTCTCCTATACCTATGCAAAGTAGGAAGAGCACCTTATAGGAGGCACTGTATAGGGACAG GGGACATGGGATCAGCCATAGGAATGTTAAATGAAATTGCACAGAGGAAAGTTTAATATATGTCTAGAGATTATACATACACTTTTTTAA GCGTAAAAAGAAGACATCTAGTAATGACAGATATTCTTTTTATATACAAGCAAAAGAAAGTATAAGGAGGTTCTACAGTGCAACATCCAC AATCTGTGCATTCACATATTATGGGACTTTTATTTTTTAAACTCTCATATAAATTTTTTAAAATTACTCCTTGGAAGAGATCCTGGTTTT TTTCTTCATTTATTTTTTTCTTTAAAAACATTTATTTTAAGAGAAGAGAAAAAGAGCTTCATCTAATTTTGCATCTTGATTACCAATCAG TACTAGTCACAGCACCAGCAATACTGTATGTTTTAGACTGACAAGGTCAGCCAGGAAATGGCATTTTTTTAAACGCAGAAATGTGTTTGT TTCCTCTACTCTAACACGTCCTTTCTCCTCCTGGTGTCCTGTCACCCCCCATGCAGCACCACTGATGCGAGATGATGCTCTGGCCTGGTC CAGGAAGCCCTGAGCCATGGGCAGATTGCCCAGTGGCCTTGGGCGGCCAGAGCTTGTCACCTGTTTAAACAAGTTCACCATGTGTTTAAA TGACAGGGTACAGTCCTGGACCAGAGGTTTTTCTCTTCAGCAAAGCTCCCTGGCCCTTGATCGTTGGACTGTTACTAATAGAAAAAGATT CAAGTCATGAAGTATAAAATCCATCCCCCATCCCAGAACTTTGAAACACAAGGAGGGAGAGATCTTTGCTATGGAGCAGTCCTGGAGCAA AGCCCCGTGGCTTCCACCCCCAGATATATACCCCATAAGTAGTGCTGAGCTCCAGCTTAGCTGAGCCAAGCTCAGTCCTTATCTGGTGTT CAGCCAGTGCACAGGTATAAGCAGAACTACAGAGCTGAATGTAGCTTCCCTGGGATCTCTTCTCCTTTCTAAAGCATTTTTCACACAGTT CTGTACCTCCTACCCAAGTTGGGGCTGCTTTCTGCCTGCTAGCCCACGGCTCTGTGTACTTTCTTTTCTGGCTTCAGGTGCAGACAGACC CTCAGTACCTTCCTGGACACAGACACATATTCCCTGGACCAAGGCGTGGAATAACTAGTAGACCACCAAGCCACAGGTGGCTGGTCTTGA AGAAAAGGGATTATACTCCTTACAGGCCACCCAGAAAGCTATGAATTCCAATATACACCACTGATCGTGCAAGTTAGGGTTTTTTTTTTT TAAACGTAGCATTATTTTGTTATATTTTGGAACTAAATGAAGTGCCAAATTAACCAGACATTCGTTTGATGCCATCTCTGTGGAACCAAG TTCTCTGTGTGTGTTCGTTTGGCTGGGAGGAGGGGGAGGACTGGGCAGACTGCTCCCACAGCAGGCTGGCAGTGGAACTGGAGCCCTGGC CACCGCAGGGAGCTCAGAGGCCAATCTACGCAAAAGGCATGCAAAACAATGGATTCTGGTCCCAAAATATTTCTAAGTAAGGCATGATGT AGCCTTTTGATTTTTTTTTTATCCTTTGACACCCCAGCCTTCAGAAAAGGTTTTTCATCTCTCTCCAAAGAAGTCATTTCATAGTGACTG ACAGGACATTCTCCAGAGAGCGACAAAGCAGAGTGGCCAGCAGGCAGTGGTGTTAAGCCTTGGGCCTTCCCAGCAGATGTGTGCTGCATT GGTGGGTGGGAGGCAGTGTGACAGCCTGGAGAAAACACACAGGTAGCAAGGGAGTCAGGGGGGAGGTACAAGAGGGCTGTGGACACCTGG CTCTTGCTCATCTTCTTGGTGCTGATCAGCTGGTGGTCACCATCCCTAAGTACCTCCCAGGGAGCTGCCATTTTCTCCTCTGGGAGCAGC TGCCTGAAGCAAGGAGAGAATGACCTGAAGGGAAGTACCTCCGGCCAAGAGTGCAGGGCTGCTGTGCCTAGCCTGAGCGGGCCATCTCTA GCAGATATGGACTTCTCTCCACCACACTAGCTGAAAAGTTTTCTCCCTTGGTTGGCAAAAGCCAGTGTCAGGAAAAAAGCTGTGGGTTTC TGACCAAGAATGTGTGCGCTTAGCTGCAAAGTGCCTGTCAGCAGCTCCAGGCACCAACAAGGTGCCCTTTTATTAGACAATTCCTGCCCG AACATAACCATATTGCAGATGAAAATTTTCAATAGAGAATGACACAATTCTTGACCTTTCTAAAAACTTTTCAAAGAGATAGTCACATGT GTATATGTTGCAAAAGATTTTTGAAACTGAAATGTCCTCCATTAAATCTCAAGAGCACTCGAGTTTTAAGTCTGCTGTTTCTGGTGTCAC ACTAAGACACACTTTTGAAAGCAGCCCTGGGTTCTGAATTAGTTGGCACTGCTGAATCCATGTTCCCCCTTCATCAGACTCCAAAGTGCA GCATTCACTTGCAAAGGTTGAGAGAAAAGTGGCCAGAATTGTACATATAACAGAGAATACCTTGAGAATAGTAGCAAAATACTGTAAATA ATATTCATTTCCTCAGGGAAAAATAAAGGGCATGCAAAAATAGGTCTGGAGACTCCTGAAACTAGGAAGAATTTTGTTATCACTAAAGTC TTTTATAGTCAGAACAATTTTTTTTTCAAATGAACATGGTATCATTTCAAGACAAATTTATGTGAACTGGGCAGTACTGACATTTGTGAG GCATAGGGGAGTGCCCTGGGAAAACGGTTTGGAGCTGACCTGTAGCCTAAGGCTAACATTTGAACCACAGGTGCAATGCCTGGGGGTGGG GGAGGGGGACGGGGTGGGGGTGGTATTCCTAGACTCACGTAAGGCTTTTTCTGAATGTAATTGTGAATACAAAGCCTTGCTGGTCCTTTT TATCATTACCCAATGGATGACTGTTTATTAGCTATCAGCAGAATTCCGTAGGCGAAAGCAAGCCGTGAACGATGTACATTTTGCTTTAAT AGCATGTTAGCGAACAAACTTCCATGGACTTTTGTGGACAAGGTGCTGCTTTTTCTCATGACCCTGTAGAATTGCTATCGACCACATCTT CTGTAGCACTGACCTGTGTGAACTCAGGGAAGAATTTGTGCATACAAATGAGTGGAAACAGAGCAGGATTCATGAATATGAATGAGAATG TGAATCATTTTGGAGAATGCCCTGGGCACACGGGTCAACTGGAAATTTCATTTCTCTAAGAAAGTAGCCCTACCAGCGGCACGGACTGTT CCTGTTCCTCATACCTGTGGGGATTCCTCCATATTGGAACTGTTTCATGTATCTTTTTTGCATTGTAACTAGCCAAACCTGAAGTCAGTA AATAAAATGAGATTAGCACTTTTTTTAGGTACCAGTTGTATCACTGAGTAATGCACACCAATAGAGCAAGAAAGTATAAAATGTATTTAA GACCAACTGGTTTGCTTATTATGACTGACTTTGAAAAAGCCCATATCCAATGATATACATGCTTTAAAAGGTATATCTATCGTAGGACCA GGAACCAAAATGGGAATTTTACTTCTGGTCCTGTTTTGTAAATAGTTCCTTTTTTTGAAGACAATCTCATGTTTTATAACTTTTGTTGTG GGTCTGAGAATCACAATGGTAATATGTCTTGGCAAAACATAACCTTTAAATACAAAAACAATTATAACTTAATTTTCCAAATAAAACAAG AAATACACTGATTAGGCTTCTACAGTTCTAAGAGACATGACACTTTGGTAATAAGCGTCAGTACTCTACTTCTCAAGTTAACTGGAAATA TTTTACAAGATGCAGTGTTTTGTAATCACAAAGAACGCAGACATTTTGTGAGAAATGACCTTGGTTTTATACATTGTAGCTTATTTTTTA AAATATAGTATTTTACCAGGCAGGAAGTATTAATATTATAAGTAATTCTTGCTCACCAAACAAAGGGCTATGTCTCTTTTAAGCAAATGT TTTGATGCATATCTTTTTAATTAACCCTCTGCAGCAAGGGTAGAAATACAGATCAGATGGAATGGGTATTATAGGAGAATCAAGATAGCA ACAGCTACTCCTTTTACCATTACTAGTGTGTTTTCAAAGTATGGAAAAAGATGCCTGAAGAGTCATTTTATATATTTTAAATCTAAAAAG TGTTAACAGGTATGCTTATAGGCCATGGGAGAAATATTCTTATAAATTTTTTAGTGTAAAATGATAAATTCTGTGTCACAAAGACAAGTT TACCACTTGACCTACCAGAATCACAGATACTTGCATTTAACTAGCAAGTATCATTTGGTGGAAATTTCTAAAATCATAGTAGACAGGCCC AAAGATAGAATTCTTAGGTGATCAGTAGTGTTTAAAATAATTTTGTCCTCAGCACTAACTATATAACTGTAATTTCTACATAAGAACAAG TGCTTCCAAAATATAGTGGAGGGAAAAAATAAAAAAGGAAAATAAAAAAACAAAACAAAAAGAACAAGTGCTTGATTTTTCACTGTGAAG AACTAGCAGGCACATGAGGTTGTGATCAGAAAGTGACTGAGTTCCCAAGAACCAGGAAACAGAGGGGAGTTGTGAAGAGTTTATTAAAAC TGTACAAATAATTCAGAGCTTTGCCAAAACCATTTCATAATGCTGTACAGTTTTTTCAAGCCCACTCACTGTTAAAACAAGAAAGCACCT TTTCTTTCTAAGATTTTAGTAATCCAAAAGCTAGCCTAATTAGCCAAGTATGCAGATAACATCAAAAGCAAAGCTGAGATAGAACAGCCA TACACCCGTTGGGCAGCTCTTATGAGGTGGTCAGAAGGTCACTCAGACCTTGGTTTCAAATAGGCTTTAGAATCTGCACACTTGAGGACT AGAAATGCACAGAGTTAGGGAAAGCCATGTACAGGCTTGGCTCCTAGTCTTTGAGATGAGGCGTCTTGCAAATCTCTGTTTTCACTCCTT GGAATGTCTCCATTGTTAGCATTAAAGTCCCCAAGAAGTTTTTATTGCTGTACGGTTTTGAACCCAATGAGTCTCATTTCCAAAAGATTC CTAATTCTATATAGGAGAGGTTGCAAATGTCAGTGCCTCAGAAGGACCAGGCAAGTTCTGTAAATGATTGATGTGGATAAGGCAAAGAGG AACACAAGAATGGTGGAGACCAGGTTGAACTGCAGAACACATGCCCTCTTTGAAGGGGTGCCCACACTCAGCTCTAGACAATCAGAACCA TGCAGAAATCAGGCCCAGGGCTGCTAGATCTTCTGACGTGGAAGTATGATATTACCTGACACGTAAGTGTTGACAACTAACTCAAACTCT TGGCCAACACTGTGCAGACCAAAGAGAAGCTGTACACAGACAGGTGCAGCCTGCAGCCCCCAGTTTCAACTATTGGGAAAAGTGGATTTC ACATTCCACAGTTGTCAGGTCAGGTTCATCCATCAGCCCCACAAACTCACATGTCGGCACTATCTGGGCAACTAAAATAAAAGAGGGGAA AGAGATCATTTCTCCCCAGATATCATTCTCATGGCAGACTTGAATATAGATACGCTGAGTTATCCAGCTCTCTCACTCTGCCTCCTTTTG GCATGCCCAGGCTGTGCCCCGTAAAGTGTTGAATCACTGTTATCCTAATTTTCTTAGTGTTTTCTACCGTGGCCACTGTGATGAGGGGCT GGCAAAGAGCAGCCTCGTGCCTTCCGAGAAGGCTGCCAGGAGCCTCTGAAGCTTGAAGCGAGCACACATTGCCTCCTTGTGCCAAAGCCC TTGGCCAGCCTCCCCACACTCCTTCCCTCTCCATCCGGCCTCATGAGTCTTCGTTACCAAGTAAAATTACCACTGCTTCACCTCTGATAC AGCAGAAGCCTTGCTTCAGAACTGGTAGGCATTTAGGCTATTTCAGAGTGTCCACTAACCTCAAAAGGAGGTTTTTCCACATACAAAACC CTAGCATCTTTGAGGGGAAAGCAAAATGAGAATAAATTATGTCATGAAAAAAATTAGAAGTTGCTTCCTTCATTTAGATGGACTAAGTTA TTTTAAACTCTATCTTACATCAGAGTCCTGATGGTGTTGGGATAGTCACTGACCCTTTCACGTATGTAATAAGATACGTCTCGTTCACAC ACTATTTCATTTGATCTTTGTAAGAACCCAGTGTAGAATAGGAATATTTAAAATCAACATTACCCACCTCCAAGGCCAACCCAGAGTAGT CTTGAACCTGAGTCAGCCTCAGTATTGCTTGCAAGGAAGAGGGAAGGGGCTCATTAAAGGCCTGGCTCAAACCTTAGTCTTCCAGACTGA CTAGGGACGTAAGAAGACCCAGGGACCCACCATGTTCTCAAACCATCTATTCAGTCCAGGCCTTTCAGCATAGACATAAAGAGCCCACCC GTTACTCAGTCATGTTGCCAAGTGCAAACTGATTTATCCCCAGATGAATCCCTTTACTGTAGCAGATCCCTAATCCCTAAATTTCAGCCA ATTTGGTAGTTAATTATAGGAGTTTATTAGCTAAATGTATGTTCTGAGTAAAAGTTTTGACTCTTTGGGGAAAATTTATTTTGCTGCTAG CATACAACATTTGCTATGTATATAAACTTAAGTCAATGCCAGAAATTTTAAAACCAGCTCAAATTTATAATCTGTAATGATCAAATCAAA ACATACTGTAAACTCAGAGTTGGAAACGCCTGGTAATATGGTTAAGTCATGTTTAAATATGAATGCAATTTAAATGACATTGGCAATGCC TGAGATTTCTTTCATTGTGAATGATTAAAAGGCAGTCCAATATATGAATGGATTTCATCTTACCTTTCTCCCGTTAATTTACTAGGTGTA ACATCTTGAGTGTAAAGTCATTCACAGGCAGTTGGGTTGTGGAGCTAGAAGGAGCCTCAAAAAAAAACTTTTTGGCCAGACTCCTACATC ATGAACAGGGTTTTTGATGAATAATATTTATTATTATGTTTCTAAAGTAATACAGTGTTGGAGAATGAAACAGTTTAGTCCTTTCCTCTT CTGATGGAAAAGAATCATAGCGCCGTTGCCATGACAATAACAGGATGTAGAAAGACCCATGAAGAAAGAAAGAAGAAAGCTATGGTTCCG AAAGCAGGTAACCACAGATTTTGAAAGGAGGCAGAGATGGTGATTAAACTGTAGTCCTTGTTTTTTAAAATGTTCTTTCATGTTAGGCAC CACCACATAGTTAATAACTACCAACTTCTAAAGAGAAGATCCCCTTGATTTATTTATATCATGAAAATACTAAAAATCAATTCTCAAGTC TAATTAACTATTACATTATCTTGCTAGGTCCTTTTCCCTAAATTTTTAATTCAGAAAATTAACCAGAATTGGCCAGATGCAGTGGTTCAC GCCTATAATCCCAGCACTTTGGGAGTCCAAGGCAGATGGATCACTTGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACAGAGGAAGAAAG AGTGAAAACAAAAGAAGAAAGAGGGAAACCCTGTCTTTACTAAAAATACAAAAATTAGTCGGGCGTGGTGGCGCACACCTGTAATTCCAG CTACTTGAGAGGCTGAGGCAGGAGAATCCCTTGAAACTGCAGGCAGAGGTTGCAGTGAGCCAAGATTTCACTGCTGCACCTGGGGTGAGA CTACCATTAAGGAAGGAAATTTCCTTTAAACAGAAAAAAACAAAGGTGCTCATCTATTTCTTCTGAATTCTCTCTACATCCTTGACTTAA GAGGAAAACCAGCACTCAAGAAACAGCTTTAAAAGAGAACAGTCCCCATTCTAGCTACCAGTCTTGCTTTCCCCCATCTTGGCAAGCCCC AGTGAATTTGCCATTGAAAGATTACCCTCCCCTTTGCCCTCATCTGCCTGAGCTAGAGGCCAGGCTGTTGTTAATGTTTTTTCAGTTCCA AAGCCCCTGATGGGACATTCTTGTTTCTGTGCTACTGCTTTCTCTCTCTTAAATTAAGGTGCAAGGGGATAAATATTACTATAACTGGGA TGTAAGGCTCAGTCAGTGTGGCTATTCCCTCCCTTCGGGGGAAATATTCCATCTGTCTGAACGGTTTTAGGTGATCATGAGGAGAGCGGC TTAGTCACACAGCCAGCCACGCTCATCACAAAAGATTTGTTCAGACTCACTGTAAAGAATGACAAGGCAGATAGCTAATCCTTTCACTGT GCCTCAAAGCCCGCCGTGCAAGTCACCAACCCTACCGGTCCTCTCCACGTGCGAGGCTAATAGAGTGATCAGAACCAGGAATGTGAGCTG GGTTCCACCTTAGGAGGGGACAATGAGGACAGAGCAAGAGGGCTCCATGTTTAATTACTCCAGGCTCTGACTTCTGCCCACAATTACAGA GCATGAAAGCAGAATTGGCCTTTAGTAAGTGAAAAGGAAGTGGCTCCTGCAGCATATAATTGTTATAATTTCGTATTTATGGAAAGAGAA AAGGACTTCAGTCCACTCATGTTGTTAAGCACTTGTCCCTCACTCCACTGGAGCCCCCTTCCTATGTTTTGGGCACAGATGGCTGGGACC GAGAGGAAAGAGGAAGAGCGGCTGCCAGAGTGTGAATATACCCCTCAGGGATATACAGCGGAGTTTCATGATAAACTACCCATACTTTCC CAAAAAAGGTTGAGGAGCAATACATAACTTTGCAGATTACAAACCCTTGTTTTACTTTTTAAACCTTTTTTCCATACTCTGCTTATTGGA AATCGATGGCTGTGATGTGACCAACACCTGTGATGATAGCAAAGCCCCTCCTTTCACAGTCTCCTGACTGTTCGGGGAACCTCCTTGGTC ATTGGTAGAAAGCTTTAGAAAAGACTTAGCTTTTTAGGGAAGAACTAAAAAATCTCCAAAACATACTAGTCCCATGACTTCGATAACTGA AAATGTCCTGGGTGTAAACTAACCCAGGAATGTGGATCATACATGTTTTTTTTAAAAAAAATCCCTGAATCAATATTTTCCTACAACACA CCCTAAAATTCCTATTTTTGTAATTAATGGTTGGACAGTGATCAGCCATTTAAACATAGGCTTTCTGGAATAACCAGACACTAGAATAGT TTCCAAAGTGTTTTGCGTATCAAAATCCTATATACTTAGAAGAAGAACTCAGGATAAGAAAAAATCGCTAGGTCCCAAAGGGTTCATGAC TATCATCAGATGCAACTGCGAGTGGCCTACGGTCATTTTTTCAAATGAGAAGACTGGAGAGAGAGAACAACAGTAATCACAAAACCTCTG TTGCCCTTAGTCCATGACAATGTTTAAGGAAACTTTAAAAAATTAAGCCATCTTCTGAATTGTTTTCTACACCAAATCTAAAATATTAAA ATGAAATTATTAAATATTTAAAATGGGGTATTTAGTGGAAATGCAATCAGTAGAAAACATTGCTTTTTAGTGCCTGCTAAACAAGTAAAG GAGAAAGAATGAAGAGAAAACAGCAGTCCTTCCTGTGTGACACTCGTGTGGAAATGACAGGCATTCACATGTCATTGAGTGCTAACTCAA AAGCTAGGTGGCAATGCTGTCCAATGTTTAGAGATCTTTTGAAATATAATTTTACCACCATTCAGAGGTAAGTACTTGCTTAACAGAAGT CTTTAATGTTAGTGAATGAATGTATAAAATTATAAACTATGCATTTTCAAAGAGTAGCATGTATTTTGTATCGAATCCAAGTAAATTTTT TTCATAGCTACCTACCACAACTGCAAATTATTCAAAATAAACTTGGATACATATCCTTATGGGGATATGGGAAGCCCATCTATATTCTCC TACTTGATGTTTTTAAAGATTGAAACTTTATTCTGAAACATCAGGCTCTAAAAAATTCCATCATTAAGATGAATAAATGGGAAATGGTTT ATTTGTTACTTCGTAAGCATAAATGGGAAATGTTGGCTGTTAGAAAATGTGCCCAGTTCTTTAAAGGTGGATGTTCTAGTAACACTGGAT TAACAAGCAAACAAAACTGCATGAAGTGAACGAATATTTCATTGGATAAAGTTAGCATAGGTTTTATCTGCTGGGTTTAATTCTCAATCC CAGAAAAAAATATTCTTCAAGGGGTATCAGTTATAGTTTCAAAGAACAAAATATGAAAATATTGTCCAGCAAAGCAAATCATTGATCTTT TTTCAAAATTACTTATATTTTGGAAAGTCTATATAGAATATCCACAAATTTCTTCAGCCCTCTTGTTGATTTCATATTTTCATGAAACTT TTTCCCCTAATAATTTGTCTTCGCTCTTTAATCAGTGCTTTACTACATTACTCAGCCTGAAAAAATATCTTTTCCTTCATCTGACAATGT GGAAATAAAGAACTCCATTTCTGTCATTCTGGTTCTCTTCAGTGTCCATTGAGAAAGTTTCTCAACTGTTTGTAAAATACGGGGGGAAAA AAACACGCATTTCTAAACCTGGTACTTAAGGTTATACTGGATTGTTTGCTACCTAATTAGAAGTTATTGGGGAAGGGGCATTGTGTCTTT TTATATGATTTTTAGCCAAATCCAGATGTTCTGATACACATTTCTGAATACCTGTCTGACTGTAAATACAGCCTGTGGAGGTTCAGGTTG ATAAACCTTTCACCTGACTGCTCCACAGCCATGCTCCTTGCCAGCTTCTGGCACATTGTACATAGATTTGTTGAATGTTTAAATGATGTT GTTTTTCTAAATGCTGTTCTCTAAAACAATTTTTTGAATTTCTTTTGCTTTCCATTGTTTTGGACTTTGTGTGTTCGTTTTTTAAAAAAA AAAATGTTTCCTAAATATTTAACACCAGGAAAAATATTTTTAAATACACTGGTGCTAATTGAAACAGAAGGAAATTTTCAGATCGAAGAT GTACAATGTTAAATGTTCATACCAGTTAAACTGCACTTTCCCAAGGGGACAGCTGGCATCTACTTGAAATGGGCATCAAGAGACCACCAA ATGTTTACAGTTTCTGTGGCCCGTTTAAGTGTAAAATGCAGAAGTGGCTCTGTCCCCCCAGAGTTAAGGATTTGCTACACTGGTCCTCTG GAAGCATTTAAGTAGAAGAAAAGGCTTATAGTCAGAATCACTTTAGTAATCGTCTTCTGGTCCTTGGACTTTTCTGTTCTGTAATGCTTG TAACAATGAATATGGTGTTGCCAATCTAGTCTGATATCATTGTTGACCTGTACTTACTTTGTGGATGGTTCTACCTGGGGTTGCACTGGC ACAAACAGAGCCAGAACACTGGACTTTCAAAAGACCATTTTGACTTCTACAGTGTCCACACACATGAATTTAAATGCACTTGTAACTGGT >In-frame_ENST00000395912_ENST00000327835_TCGA-77-8009-01A_RRM2B_chr8_103231042_-_ZNF704_chr8_81555364_length(amino acids)=244AA_start in transcript=0_stop in transcript=734 MGDPERPEAAGLDQDEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLI DTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEVSPT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RRM2B-ZNF704 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RRM2B-ZNF704 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RRM2B-ZNF704 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RRM2B | C2749861 | MITOCHONDRIAL DNA DEPLETION SYNDROME 8A (ENCEPHALOMYOPATHIC TYPE WITH RENAL TUBULOPATHY) | 8 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | RRM2B | C2751319 | Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 5 | 3 | CTD_human;GENOMICS_ENGLAND |
| Hgene | RRM2B | C0162668 | Megaconial Myopathies | 2 | CTD_human |
| Hgene | RRM2B | C0162669 | Pleoconial Myopathies | 2 | CTD_human |
| Hgene | RRM2B | C0162670 | Mitochondrial Myopathies | 2 | CTD_human |
| Hgene | RRM2B | C0949496 | Luft Disease | 2 | CTD_human |
| Hgene | RRM2B | C1834846 | Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1 | 2 | ORPHANET |
| Hgene | RRM2B | C0001125 | Acidosis, Lactic | 1 | CTD_human |
| Hgene | RRM2B | C0022541 | Kearns-Sayre syndrome | 1 | ORPHANET |
| Hgene | RRM2B | C0022658 | Kidney Diseases | 1 | CTD_human |
| Hgene | RRM2B | C0026825 | Flaccid Muscle Tone | 1 | CTD_human |
| Hgene | RRM2B | C0026827 | Muscle hypotonia | 1 | CTD_human |
| Hgene | RRM2B | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
| Hgene | RRM2B | C0038220 | Status Epilepticus | 1 | GENOMICS_ENGLAND |
| Hgene | RRM2B | C0427201 | Floppy Muscles | 1 | CTD_human |
| Hgene | RRM2B | C0427202 | Muscle Tone Atonic | 1 | CTD_human |
| Hgene | RRM2B | C0751330 | Unilateral Hypotonia | 1 | CTD_human |
| Hgene | RRM2B | C0872218 | MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY SYNDROME | 1 | ORPHANET |
| Hgene | RRM2B | C1848586 | Visceral myopathy familial external ophthalmoplegia | 1 | CTD_human |
| Hgene | RRM2B | C2267233 | Neonatal Hypotonia | 1 | CTD_human |
| Hgene | RRM2B | C3150172 | MITOCHONDRIAL DNA DEPLETION SYNDROME 8B (MNGIE TYPE) | 1 | GENOMICS_ENGLAND |
| Hgene | RRM2B | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| Hgene | RRM2B | C4511138 | Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy | 1 | ORPHANET |
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