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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RSRC1-MLF1 (FusionGDB2 ID:77988) |
Fusion Gene Summary for RSRC1-MLF1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RSRC1-MLF1 | Fusion gene ID: 77988 | Hgene | Tgene | Gene symbol | RSRC1 | MLF1 | Gene ID | 51319 | 4291 |
Gene name | arginine and serine rich coiled-coil 1 | myeloid leukemia factor 1 | |
Synonyms | BM-011|MRT70|SFRS21|SRrp53 | - | |
Cytomap | 3q25.32 | 3q25.32 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/Arginine-related protein 53arginine/serine-rich coiled-coil 1arginine/serine-rich coiled-coil protein 1splicing factor, arginine/serine-rich 21 | myeloid leukemia factor 1myelodysplasia-myeloid leukemia factor 1testis tissue sperm-binding protein Li 49e | |
Modification date | 20200313 | 20200318 | |
UniProtAcc | . | P58340 | |
Ensembl transtripts involved in fusion gene | ENST00000480820, ENST00000295930, ENST00000464171, ENST00000312179, ENST00000475278, ENST00000496268, | ENST00000355893, ENST00000484955, ENST00000359117, ENST00000471745, ENST00000497004, ENST00000469452, ENST00000482628, ENST00000478894, ENST00000392822, | |
Fusion gene scores | * DoF score | 10 X 8 X 5=400 | 3 X 3 X 3=27 |
# samples | 10 | 3 | |
** MAII score | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RSRC1 [Title/Abstract] AND MLF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MLF1(158310370)-RSRC1(158261124), # samples:3 RSRC1(157921034)-MLF1(158310223), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RSRC1 | GO:0000398 | mRNA splicing, via spliceosome | 15798186 |
Hgene | RSRC1 | GO:0008380 | RNA splicing | 15798186 |
Tgene | MLF1 | GO:0007050 | cell cycle arrest | 15861129 |
Fusion gene breakpoints across RSRC1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MLF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | KIRC | TCGA-BP-5178-01A | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
ChimerDB4 | KIRC | TCGA-BP-5178-01A | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
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Fusion Gene ORF analysis for RSRC1-MLF1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000480820 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000484955 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000359117 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000471745 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-3UTR | ENST00000480820 | ENST00000497004 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000469452 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000482628 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000478894 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000480820 | ENST00000392822 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
In-frame | ENST00000295930 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000484955 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000359117 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000471745 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-3UTR | ENST00000295930 | ENST00000497004 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000469452 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000482628 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000478894 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000295930 | ENST00000392822 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-3CDS | ENST00000464171 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000484955 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000359117 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000471745 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-3UTR | ENST00000464171 | ENST00000497004 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000469452 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000482628 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000478894 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000464171 | ENST00000392822 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-3CDS | ENST00000312179 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000484955 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000359117 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000471745 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-3UTR | ENST00000312179 | ENST00000497004 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000469452 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000482628 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000478894 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
intron-5UTR | ENST00000312179 | ENST00000392822 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
In-frame | ENST00000475278 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000484955 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000359117 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000471745 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-3UTR | ENST00000475278 | ENST00000497004 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000469452 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000482628 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000478894 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
5CDS-5UTR | ENST00000475278 | ENST00000392822 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-3CDS | ENST00000496268 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000484955 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000359117 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000471745 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-3UTR | ENST00000496268 | ENST00000497004 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000469452 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000482628 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000478894 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
3UTR-5UTR | ENST00000496268 | ENST00000392822 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000480820 | RSRC1 | chr3 | 157921034 | + | ENST00000355893 | MLF1 | chr3 | 158310223 | + | 2670 | 652 | 128 | 1411 | 427 |
ENST00000295930 | RSRC1 | chr3 | 157921034 | + | ENST00000355893 | MLF1 | chr3 | 158310223 | + | 2674 | 656 | 120 | 1415 | 431 |
ENST00000475278 | RSRC1 | chr3 | 157921034 | + | ENST00000355893 | MLF1 | chr3 | 158310223 | + | 2605 | 587 | 93 | 1346 | 417 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000480820 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + | 0.001779455 | 0.9982205 |
ENST00000295930 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + | 0.00193055 | 0.99806947 |
ENST00000475278 | ENST00000355893 | RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310223 | + | 0.001840537 | 0.99815947 |
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Fusion Genomic Features for RSRC1-MLF1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310222 | + | 7.98E-08 | 0.9999999 |
RSRC1 | chr3 | 157921034 | + | MLF1 | chr3 | 158310222 | + | 7.98E-08 | 0.9999999 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RSRC1-MLF1 |
Go to FGviewer for the breakpoints of chr3:157921034-chr3:158310223 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | MLF1 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000295930 | + | 4 | 10 | 3_147 | 164.66666666666666 | 335.0 | Compositional bias | Note=Arg/Ser-rich |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000480820 | + | 4 | 10 | 3_147 | 164.66666666666666 | 335.0 | Compositional bias | Note=Arg/Ser-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000295930 | + | 4 | 10 | 180_236 | 164.66666666666666 | 335.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000312179 | + | 1 | 9 | 180_236 | 0 | 277.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000464171 | + | 1 | 9 | 180_236 | 0 | 277.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000480820 | + | 4 | 10 | 180_236 | 164.66666666666666 | 335.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000312179 | + | 1 | 9 | 3_147 | 0 | 277.0 | Compositional bias | Note=Arg/Ser-rich |
Hgene | RSRC1 | chr3:157921034 | chr3:158310223 | ENST00000464171 | + | 1 | 9 | 3_147 | 0 | 277.0 | Compositional bias | Note=Arg/Ser-rich |
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Fusion Gene Sequence for RSRC1-MLF1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000480820_ENST00000355893_TCGA-BP-5178-01A_RSRC1_chr3_157921034_+_MLF1_chr3_158310223_length(transcript)=2670nt_BP=652nt CGGACTGCCGGGCTGCTGCGGTCGTCGCGGCCCGCCTCGGTGCAGCCGGTCGGCTCCTTGGCCCCGCGCAGCGGCCCGCTCTCCAGCACC TCCCGGTACGTGATCGCCTCCTTCTTCTCCTTCACTTTCTGGTCAAAAGACTTGGAGACGAACGCCAAATGGGACGTCGGTCATCAGATA CTGAAGAAGAAAGCAGAAGCAAGAGAAAAAAGAAACACCGTAGACGGTCCTCCTCGAGCAGTTCTTCAGATAGTAGAACATACAGCCGAA AGAAAGGAGGAAGGAAATCAAGATCAAAGTCAAGATCTTGGTCCAGAGATCTTCAGCCTCGTTCACATTCTTATGATAGAAGACGCAGGC ATCGATCAAGCAGTAGCTCTTCTTATGGCTCCAGAAGGAAACGAAGTCGAAGTCGTTCAAGGGGTCGAGGGAAATCCTATAGAGTTCAGA GGTCTAGGTCAAAAAGCAGAACAAGAAGGTCCAGGTCAAGACCTCGTCTCCGTTCTCATAGTCGTAGCAGTGAAAGGTCCAGTCACAGAA GAACGCGTAGTCGGTCTCGGGATAGAGAACGACGTAAGGGCAGAGATAAAGAGAAAAGAGAAAAGGAGAAGGATAAAGGGAAGGACAAGG AATTACATAACATCAAACGTGGTGAGTCCATTCTTGCACACCGAGAAAATATGCGACAGATGATAAGAAGTTTTTCTGAACCCTTTGGAA GAGACTTGCTCAGTATCTCTGATGGTAGAGGGAGAGCTCATAATCGTAGAGGACATAATGATGGTGAAGATTCTTTGACTCATACAGATG TCAGCTCTTTCCAGACAATGGACCAAATGGTGTCAAATATGAGAAACTATATGCAGAAATTAGAAAGAAACTTCGGTCAACTTTCAGTGG ATCCAAATGGACATTCATTTTGTTCTTCCTCAGTTATGACTTATTCCAAAATAGGAGATGAACCGCCAAAGGTTTTTCAGGCCTCAACTC AAACTCGTCGAGCTCCAGGAGGAATAAAGGAAACCAGGAAAGCAATGAGAGATTCTGACAGTGGACTAGAAAAAATGGCTATTGGTCATC ATATCCATGACCGAGCTCATGTCATTAAAAAGTCAAAGAACAAGAAGACTGGAGATGAAGAGGTCAACCAGGAGTTCATCAATATGAATG AAAGTGATGCTCATGCTTTTGATGAGGAGTGGCAAAGTGAGGTTTTGAAGTACAAACCAGGACGACACAATCTAGGAAACACTAGAATGA GAAGTGTTGGCCATGAGAATCCTGGCTCCCGAGAACTTAAAAGAAGGGAGAAACCTCAACAAAGTCCAGCCATTGAACATGGAAGGAGAT CAAATGTTTTGGGGGACAAACTCCACATCAAAGGCTCATCTGTGAAAAGCAACAAAAAATAAATAGCCATGCATTTGATTTGTTTAGTTT TGATTGTTTTAACAGTTAGTAATGGTGCTGGGTAATAAGCATAAGACCAATCTCTTGCTGTTAAATCAGTTCTGTCCTTGGCAACTTTCT TCTGATATCTGAATGTTCATGAAGGTCCTAGCTTTATATTGTCCCTCTTTTAGGAATAAAATTTTGATTTTCAACAATGTGAGTAAATTG AGTCTATTTAATGTAAAACTCTTTAAAACATACTAATTTTTTAAAGCTTATATGCTTATTTCGCTTCCCCAGTTGTTTTTGTGTTGGCTA AATATTCTTTTATATTTATCAAGATTGATTGCAGAGCAGTTCTATCACTTATAATTAGTTATAAGAAATTATAATGTTAAAAAAGTCTCA GTTTTTACTAACACTGTACTAGGGTGATATTAATAAAGGTTTAAATAATTTATCTCTAATTTTATAATGTGTTGTAAAGCCAACTAGCTT AAAACTTTAAAAATAATAAAGCAAAACTACACTAGTACTCTTTTATGAGAAAATAGTTACTATTTTGATAAAGGGCAAGGATAATCAAAT AGTTCATTTTCAGAGAAAAATATTTTAAATTGCTAATGTACATGATTGTTTTGGTTATAATTTATTTATAGAATGTATCTTTTCTATATT ACATTCTTAATATTCACCAGATATTATATTGACCATTCTCTTTAACTTCTTAATGTGGCATATTTCTACTCTCCTTTCCCACAAACAGCT TCATCTGTCTCCAAGGTTAACATTCTGAAGCTGGAGAGTCCTTGGAGAAACTCTGCTCAGCTTTTTTGTGACATTTAGAAAAATGCATTT GGTATTCTCCAAACCAGAATGATACATTGTCTCAAAATCTGTTAGACAGCTGATGGGTGTTTTTGAGCAACGTCTTAATAATTCAGTTGT TTCTGTTTTAATTATACCATTAAAAATCAGCTTTAGCTTTTTAATTCTAGAATTTAAGCATCAGTCTGTTCTTATAAAAGTTAGGTTTGA AGTTTATAAGAATATAAAATCTTAACTCACATTTGTTGTTTAATATTTCTGTCAAGGAAAAAAGCCCCCAAAAATTGCTATCACTCTATA ATCCTAAGTATTTTTCTTTTCAATTTTGTAAGTAAAATTATATGACTATGTTCATACTTCTCTAATTTTTTATATAATATTTTTGTTAAT >In-frame_ENST00000480820_ENST00000355893_TCGA-BP-5178-01A_RSRC1_chr3_157921034_+_MLF1_chr3_158310223_length(amino acids)=427AA_start in transcript=128_stop in transcript=1411 MVKRLGDERQMGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRRRRHRSSSSSSYGSRR KRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHSRSSERSSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGESILA HRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVM TYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQS -------------------------------------------------------------- >In-frame_ENST00000295930_ENST00000355893_TCGA-BP-5178-01A_RSRC1_chr3_157921034_+_MLF1_chr3_158310223_length(transcript)=2674nt_BP=656nt GATGCACTCGATATCTCGGCTGAAGCTGCCTGGCGCTAGAACCAGGAAGGCGCTGAGCTTAAACTGAAGCAAGTTCGGTGGACGCCGGCG GCGCCCTGATCTAAAGAAACGACTCAGGGACTGCGGCGCTTGCACGTCAACGGGAGGTGTGAGCCCAAAGAAATGGGACGTCGGTCATCA GATACTGAAGAAGAAAGCAGAAGCAAGAGAAAAAAGAAACACCGTAGACGGTCCTCCTCGAGCAGTTCTTCAGATAGTAGAACATACAGC CGAAAGAAAGGAGGAAGGAAATCAAGATCAAAGTCAAGATCTTGGTCCAGAGATCTTCAGCCTCGTTCACATTCTTATGATAGAAGACGC AGGCATCGATCAAGCAGTAGCTCTTCTTATGGCTCCAGAAGGAAACGAAGTCGAAGTCGTTCAAGGGGTCGAGGGAAATCCTATAGAGTT CAGAGGTCTAGGTCAAAAAGCAGAACAAGAAGGTCCAGGTCAAGACCTCGTCTCCGTTCTCATAGTCGTAGCAGTGAAAGGTCCAGTCAC AGAAGAACGCGTAGTCGGTCTCGGGATAGAGAACGACGTAAGGGCAGAGATAAAGAGAAAAGAGAAAAGGAGAAGGATAAAGGGAAGGAC AAGGAATTACATAACATCAAACGTGGTGAGTCCATTCTTGCACACCGAGAAAATATGCGACAGATGATAAGAAGTTTTTCTGAACCCTTT GGAAGAGACTTGCTCAGTATCTCTGATGGTAGAGGGAGAGCTCATAATCGTAGAGGACATAATGATGGTGAAGATTCTTTGACTCATACA GATGTCAGCTCTTTCCAGACAATGGACCAAATGGTGTCAAATATGAGAAACTATATGCAGAAATTAGAAAGAAACTTCGGTCAACTTTCA GTGGATCCAAATGGACATTCATTTTGTTCTTCCTCAGTTATGACTTATTCCAAAATAGGAGATGAACCGCCAAAGGTTTTTCAGGCCTCA ACTCAAACTCGTCGAGCTCCAGGAGGAATAAAGGAAACCAGGAAAGCAATGAGAGATTCTGACAGTGGACTAGAAAAAATGGCTATTGGT CATCATATCCATGACCGAGCTCATGTCATTAAAAAGTCAAAGAACAAGAAGACTGGAGATGAAGAGGTCAACCAGGAGTTCATCAATATG AATGAAAGTGATGCTCATGCTTTTGATGAGGAGTGGCAAAGTGAGGTTTTGAAGTACAAACCAGGACGACACAATCTAGGAAACACTAGA ATGAGAAGTGTTGGCCATGAGAATCCTGGCTCCCGAGAACTTAAAAGAAGGGAGAAACCTCAACAAAGTCCAGCCATTGAACATGGAAGG AGATCAAATGTTTTGGGGGACAAACTCCACATCAAAGGCTCATCTGTGAAAAGCAACAAAAAATAAATAGCCATGCATTTGATTTGTTTA GTTTTGATTGTTTTAACAGTTAGTAATGGTGCTGGGTAATAAGCATAAGACCAATCTCTTGCTGTTAAATCAGTTCTGTCCTTGGCAACT TTCTTCTGATATCTGAATGTTCATGAAGGTCCTAGCTTTATATTGTCCCTCTTTTAGGAATAAAATTTTGATTTTCAACAATGTGAGTAA ATTGAGTCTATTTAATGTAAAACTCTTTAAAACATACTAATTTTTTAAAGCTTATATGCTTATTTCGCTTCCCCAGTTGTTTTTGTGTTG GCTAAATATTCTTTTATATTTATCAAGATTGATTGCAGAGCAGTTCTATCACTTATAATTAGTTATAAGAAATTATAATGTTAAAAAAGT CTCAGTTTTTACTAACACTGTACTAGGGTGATATTAATAAAGGTTTAAATAATTTATCTCTAATTTTATAATGTGTTGTAAAGCCAACTA GCTTAAAACTTTAAAAATAATAAAGCAAAACTACACTAGTACTCTTTTATGAGAAAATAGTTACTATTTTGATAAAGGGCAAGGATAATC AAATAGTTCATTTTCAGAGAAAAATATTTTAAATTGCTAATGTACATGATTGTTTTGGTTATAATTTATTTATAGAATGTATCTTTTCTA TATTACATTCTTAATATTCACCAGATATTATATTGACCATTCTCTTTAACTTCTTAATGTGGCATATTTCTACTCTCCTTTCCCACAAAC AGCTTCATCTGTCTCCAAGGTTAACATTCTGAAGCTGGAGAGTCCTTGGAGAAACTCTGCTCAGCTTTTTTGTGACATTTAGAAAAATGC ATTTGGTATTCTCCAAACCAGAATGATACATTGTCTCAAAATCTGTTAGACAGCTGATGGGTGTTTTTGAGCAACGTCTTAATAATTCAG TTGTTTCTGTTTTAATTATACCATTAAAAATCAGCTTTAGCTTTTTAATTCTAGAATTTAAGCATCAGTCTGTTCTTATAAAAGTTAGGT TTGAAGTTTATAAGAATATAAAATCTTAACTCACATTTGTTGTTTAATATTTCTGTCAAGGAAAAAAGCCCCCAAAAATTGCTATCACTC TATAATCCTAAGTATTTTTCTTTTCAATTTTGTAAGTAAAATTATATGACTATGTTCATACTTCTCTAATTTTTTATATAATATTTTTGT >In-frame_ENST00000295930_ENST00000355893_TCGA-BP-5178-01A_RSRC1_chr3_157921034_+_MLF1_chr3_158310223_length(amino acids)=431AA_start in transcript=120_stop in transcript=1415 MRRLHVNGRCEPKEMGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRRRRHRSSSSSSY GSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHSRSSERSSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGE SILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCS SSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDE -------------------------------------------------------------- >In-frame_ENST00000475278_ENST00000355893_TCGA-BP-5178-01A_RSRC1_chr3_157921034_+_MLF1_chr3_158310223_length(transcript)=2605nt_BP=587nt AGCTTAAACTGAAGCAAGTTCGGTGGACGCCGGCGGCGCCCTGATCTAAAGAAACGACTCAGGGACTGCGGCGCTTGCACGTCAACGGGA GAAATGGGACGTCGGTCATCAGATACTGAAGAAGAAAGCAGAAGCAAGAGAAAAAAGAAACACCGTAGACGGTCCTCCTCGAGCAGTTCT TCAGATAGTAGAACATACAGCCGAAAGAAAGGAGGAAGGAAATCAAGATCAAAGTCAAGATCTTGGTCCAGAGATCTTCAGCCTCGTTCA CATTCTTATGATAGAAGACGCAGGCATCGATCAAGCAGTAGCTCTTCTTATGGCTCCAGAAGGAAACGAAGTCGAAGTCGTTCAAGGGGT CGAGGGAAATCCTATAGAGTTCAGAGGTCTAGGTCAAAAAGCAGAACAAGAAGGTCCAGGTCAAGACCTCGTCTCCGTTCTCATAGTCGT AGCAGTGAAAGGTCCAGTCACAGAAGAACGCGTAGTCGGTCTCGGGATAGAGAACGACGTAAGGGCAGAGATAAAGAGAAAAGAGAAAAG GAGAAGGATAAAGGGAAGGACAAGGAATTACATAACATCAAACGTGGTGAGTCCATTCTTGCACACCGAGAAAATATGCGACAGATGATA AGAAGTTTTTCTGAACCCTTTGGAAGAGACTTGCTCAGTATCTCTGATGGTAGAGGGAGAGCTCATAATCGTAGAGGACATAATGATGGT GAAGATTCTTTGACTCATACAGATGTCAGCTCTTTCCAGACAATGGACCAAATGGTGTCAAATATGAGAAACTATATGCAGAAATTAGAA AGAAACTTCGGTCAACTTTCAGTGGATCCAAATGGACATTCATTTTGTTCTTCCTCAGTTATGACTTATTCCAAAATAGGAGATGAACCG CCAAAGGTTTTTCAGGCCTCAACTCAAACTCGTCGAGCTCCAGGAGGAATAAAGGAAACCAGGAAAGCAATGAGAGATTCTGACAGTGGA CTAGAAAAAATGGCTATTGGTCATCATATCCATGACCGAGCTCATGTCATTAAAAAGTCAAAGAACAAGAAGACTGGAGATGAAGAGGTC AACCAGGAGTTCATCAATATGAATGAAAGTGATGCTCATGCTTTTGATGAGGAGTGGCAAAGTGAGGTTTTGAAGTACAAACCAGGACGA CACAATCTAGGAAACACTAGAATGAGAAGTGTTGGCCATGAGAATCCTGGCTCCCGAGAACTTAAAAGAAGGGAGAAACCTCAACAAAGT CCAGCCATTGAACATGGAAGGAGATCAAATGTTTTGGGGGACAAACTCCACATCAAAGGCTCATCTGTGAAAAGCAACAAAAAATAAATA GCCATGCATTTGATTTGTTTAGTTTTGATTGTTTTAACAGTTAGTAATGGTGCTGGGTAATAAGCATAAGACCAATCTCTTGCTGTTAAA TCAGTTCTGTCCTTGGCAACTTTCTTCTGATATCTGAATGTTCATGAAGGTCCTAGCTTTATATTGTCCCTCTTTTAGGAATAAAATTTT GATTTTCAACAATGTGAGTAAATTGAGTCTATTTAATGTAAAACTCTTTAAAACATACTAATTTTTTAAAGCTTATATGCTTATTTCGCT TCCCCAGTTGTTTTTGTGTTGGCTAAATATTCTTTTATATTTATCAAGATTGATTGCAGAGCAGTTCTATCACTTATAATTAGTTATAAG AAATTATAATGTTAAAAAAGTCTCAGTTTTTACTAACACTGTACTAGGGTGATATTAATAAAGGTTTAAATAATTTATCTCTAATTTTAT AATGTGTTGTAAAGCCAACTAGCTTAAAACTTTAAAAATAATAAAGCAAAACTACACTAGTACTCTTTTATGAGAAAATAGTTACTATTT TGATAAAGGGCAAGGATAATCAAATAGTTCATTTTCAGAGAAAAATATTTTAAATTGCTAATGTACATGATTGTTTTGGTTATAATTTAT TTATAGAATGTATCTTTTCTATATTACATTCTTAATATTCACCAGATATTATATTGACCATTCTCTTTAACTTCTTAATGTGGCATATTT CTACTCTCCTTTCCCACAAACAGCTTCATCTGTCTCCAAGGTTAACATTCTGAAGCTGGAGAGTCCTTGGAGAAACTCTGCTCAGCTTTT TTGTGACATTTAGAAAAATGCATTTGGTATTCTCCAAACCAGAATGATACATTGTCTCAAAATCTGTTAGACAGCTGATGGGTGTTTTTG AGCAACGTCTTAATAATTCAGTTGTTTCTGTTTTAATTATACCATTAAAAATCAGCTTTAGCTTTTTAATTCTAGAATTTAAGCATCAGT CTGTTCTTATAAAAGTTAGGTTTGAAGTTTATAAGAATATAAAATCTTAACTCACATTTGTTGTTTAATATTTCTGTCAAGGAAAAAAGC CCCCAAAAATTGCTATCACTCTATAATCCTAAGTATTTTTCTTTTCAATTTTGTAAGTAAAATTATATGACTATGTTCATACTTCTCTAA >In-frame_ENST00000475278_ENST00000355893_TCGA-BP-5178-01A_RSRC1_chr3_157921034_+_MLF1_chr3_158310223_length(amino acids)=417AA_start in transcript=93_stop in transcript=1346 MGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRRRRHRSSSSSSYGSRRKRSRSRSRGR GKSYRVQRSRSKSRTRRSRSRPRLRSHSRSSERSSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGESILAHRENMRQMIR SFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPP KVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RSRC1-MLF1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000355893 | 0 | 7 | 50_125 | 15.666666666666666 | 269.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000359117 | 0 | 7 | 50_125 | 0 | 244.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000392822 | 1 | 9 | 50_125 | 31.666666666666668 | 300.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000469452 | 1 | 7 | 50_125 | 0 | 201.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000471745 | 1 | 9 | 50_125 | 0 | 259.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000478894 | 1 | 9 | 50_125 | 0 | 259.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000482628 | 1 | 8 | 50_125 | 0 | 244.0 | COPS3 | |
Tgene | MLF1 | chr3:157921034 | chr3:158310223 | ENST00000484955 | 1 | 8 | 50_125 | 0 | 244.0 | COPS3 |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RSRC1-MLF1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RSRC1-MLF1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MLF1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Tgene | MLF1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | MLF1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |