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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP11B-PLSCR1 (FusionGDB2 ID:7822)

Fusion Gene Summary for ATP11B-PLSCR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11B-PLSCR1
Fusion gene ID: 7822
HgeneTgene
Gene symbol

ATP11B

PLSCR1

Gene ID

23200

5359

Gene nameATPase phospholipid transporting 11B (putative)phospholipid scramblase 1
SynonymsATPIF|ATPIRMMTRA1B
Cytomap

3q26.33

3q24

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B proteinphospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblase
Modification date2020031320200313
UniProtAcc

Q9Y2G3

.
Ensembl transtripts involved in fusion geneENST00000323116, ENST00000493826, 
ENST00000482794, 		ENST00000342435, 
ENST00000448205, ENST00000487389, 
ENST00000448787, ENST00000484560, 
Fusion gene scores* DoF score20 X 15 X 10=300011 X 9 X 2=198
# samples 2211
** MAII scorelog2(22/3000*10)=-3.76938707185858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/198*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP11B [Title/Abstract] AND PLSCR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP11B(182511574)-PLSCR1(146243434), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLSCR1

GO:0006915

apoptotic process

10770950

TgenePLSCR1

GO:0017121

phospholipid scrambling

9218461|10770950|18629440

TgenePLSCR1

GO:0045944

positive regulation of transcription by RNA polymerase II

16091359

TgenePLSCR1

GO:2000373

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

17567603


check buttonFusion gene breakpoints across ATP11B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLSCR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7901ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-


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Fusion Gene ORF analysis for ATP11B-PLSCR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000323116ENST00000342435ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-5UTRENST00000323116ENST00000448205ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-5UTRENST00000323116ENST00000487389ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-5UTRENST00000323116ENST00000448787ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-intronENST00000323116ENST00000484560ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
In-frameENST00000493826ENST00000342435ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-5UTRENST00000493826ENST00000448205ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-5UTRENST00000493826ENST00000487389ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-5UTRENST00000493826ENST00000448787ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
5CDS-intronENST00000493826ENST00000484560ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
intron-3CDSENST00000482794ENST00000342435ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
intron-5UTRENST00000482794ENST00000448205ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
intron-5UTRENST00000482794ENST00000487389ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
intron-5UTRENST00000482794ENST00000448787ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-
intron-intronENST00000482794ENST00000484560ATP11Bchr3

182511574

+PLSCR1chr3

146243434

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323116ATP11Bchr3182511574+ENST00000342435PLSCR1chr3146243434-1797287206931241
ENST00000493826ATP11Bchr3182511574+ENST00000342435PLSCR1chr3146243434-1794284203928241

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323116ENST00000342435ATP11Bchr3182511574+PLSCR1chr3146243434-0.000142410.99985754
ENST00000493826ENST00000342435ATP11Bchr3182511574+PLSCR1chr3146243434-0.0001539920.999846

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Fusion Genomic Features for ATP11B-PLSCR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP11B-PLSCR1


check button Go to

FGviewer for the breakpoints of chr3:182511574-chr3:146243434

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11B

Q9Y2G3

.
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLSCR1chr3:182511574chr3:146243434ENST0000034243539181_189104.0319.0Compositional biasNote=Cys-rich
TgenePLSCR1chr3:182511574chr3:146243434ENST0000034243539257_266104.0319.0MotifNuclear localization signal
TgenePLSCR1chr3:182511574chr3:146243434ENST0000034243539306_318104.0319.0Topological domainExtracellular
TgenePLSCR1chr3:182511574chr3:146243434ENST0000034243539289_305104.0319.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+1301021_10259.01178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+1301048_10659.01178.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130105_2899.01178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+1301091_11779.01178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+1301_559.01178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130312_3419.01178.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130360_8769.01178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+13078_829.01178.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130899_9109.01178.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130931_9609.01178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130983_9979.01178.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+161021_10259.0196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+161048_10659.0196.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16105_2899.0196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+161091_11779.0196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+161_559.0196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16312_3419.0196.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16360_8769.0196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+1678_829.0196.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16899_9109.0196.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16931_9609.0196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16983_9979.0196.0Topological domainExtracellular
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+1301026_10479.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+1301066_10909.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130290_3119.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130342_3599.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+13056_779.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+13083_1049.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130877_8989.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130911_9309.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130961_9829.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000323116+130998_10209.01178.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+161026_10479.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+161066_10909.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16290_3119.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16342_3599.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+1656_779.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+1683_1049.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16877_8989.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16911_9309.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16961_9829.0196.0TransmembraneHelical
HgeneATP11Bchr3:182511574chr3:146243434ENST00000493826+16998_10209.0196.0TransmembraneHelical
TgenePLSCR1chr3:182511574chr3:146243434ENST000003424353918_26104.0319.0MotifSH3-binding 1
TgenePLSCR1chr3:182511574chr3:146243434ENST000003424353922_25104.0319.0MotifPPXY motif 1
TgenePLSCR1chr3:182511574chr3:146243434ENST000003424353933_36104.0319.0MotifPPXY motif 2
TgenePLSCR1chr3:182511574chr3:146243434ENST000003424353942_50104.0319.0MotifSH3-binding 2
TgenePLSCR1chr3:182511574chr3:146243434ENST000003424353984_92104.0319.0MotifSH3-binding 3
TgenePLSCR1chr3:182511574chr3:146243434ENST00000342435391_84104.0319.0RegionProline-rich domain (PRD)
TgenePLSCR1chr3:182511574chr3:146243434ENST00000342435391_288104.0319.0Topological domainCytoplasmic


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Fusion Gene Sequence for ATP11B-PLSCR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000323116_ENST00000342435_TCGA-BR-7901_ATP11B_chr3_182511574_+_PLSCR1_chr3_146243434_length(transcript)=1797nt_BP=287nt
GGTCAATAATGAAGGTGGCTGCGGCGCGGCGGCAGGCTCAGCTGCGCCGGGCGGGGGCGGCGCCGGGGCCGCGCCTGTAGGACTCGGGGC
CGACGCCGCGGGATGGGGACGCGGCGCGGGGAGTGAGGCAGTGGCGGCGGCGGCGGTAAGCGGAACTTCGGCCCGAGGGGCTCGCCCGCT
CCCGCCTCTGTCTTGTCGGCCTCCACCTGCAGCCCCGCGGCCCCCGCGCCCCGCGGGACCCGGACGGCGACGACGGGGGAATGTGGCGCT
GGATCCGGCAGCAGCTGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAAACTAATAACAAAT
ATGAAATTAAGAACAGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGTGGGCCATCTAGAC
CTTTTACCTTGAGGATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGTTGTTGTCCCTGCT
GCCTTCAGGAGATAGAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTACCAAAGTTTACAA
TTCAAAATGAGAAAAGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGATTTTGAGATTAAAT
CTCTTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAA
TCCAGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTGACTTCATGTTTTTTGAAAGCACTG
GCAGCCAGGAACAAAAATCAGGAGTGTGGTAGTGGATTAGTGAAAGTCTCCTCAGGAAATCTGAAGTCTGTATATTGATTGAGACTATCT
AAACTCATACCTGTATGAATTAAGCTGTAAGGCCTGTAGCTCTGGTTGTATACTTTTGCTTTTCAAATTATAGTTTATCTTCTGTATAAC
TGATTTATAAAGGTTTTTGTACATTTTTTAATACTCATTGTCAATTTGAGAAAAAGGACATATGAGTTTTTGCATTTATTAATGAAACTT
CCTTTGAAAAACTGCTTTGAATTATGATCTCTGATTCATTGTCCATTTTACTACCAAATATTAACTAAGGCCTTATTAATTTTTATATAA
ATTATATCTTGTCCTATTAAATCTAGTTACAATTTATTTCATGCATAAGAGCTAATGTTATTTTGCAAATGCCATATATTCAAAAAAGCT
CAAAGATAATTTTCTTTACTATTATGTTCAAATAATATTCAATATGCATATTATCTTTAAAAAGTTAAATGTTTTTTTAATCTTCAAGAA
ATCATGCTACACTTAACTTCTCCTAGAAGCTAATCTATACCATAATATTTTCATATTCACAAGATATTAAATTACCAATTTTCAAATTAT
TGTTAGTAAAGAACAAAATGATTCTCTCCCAAAGAAAGACACATTTTAAATACTCCTTCACTCTAAAACTCTGGTATTATAACTTTTGAA
AGTTAATATTTCTACATGAAATGTTTAGCTCTTACACTCTATCCTTCCTAGAAAATGGTAATTGAGATTACTCAGATATTAATTAAATAC

>In-frame_ENST00000323116_ENST00000342435_TCGA-BR-7901_ATP11B_chr3_182511574_+_PLSCR1_chr3_146243434_length(amino acids)=241AA_start in transcript=206_stop in transcript=931
MQPRGPRAPRDPDGDDGGMWRWIRQQLIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDN
MGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVG

--------------------------------------------------------------
>In-frame_ENST00000493826_ENST00000342435_TCGA-BR-7901_ATP11B_chr3_182511574_+_PLSCR1_chr3_146243434_length(transcript)=1794nt_BP=284nt
CAATAATGAAGGTGGCTGCGGCGCGGCGGCAGGCTCAGCTGCGCCGGGCGGGGGCGGCGCCGGGGCCGCGCCTGTAGGACTCGGGGCCGA
CGCCGCGGGATGGGGACGCGGCGCGGGGAGTGAGGCAGTGGCGGCGGCGGCGGTAAGCGGAACTTCGGCCCGAGGGGCTCGCCCGCTCCC
GCCTCTGTCTTGTCGGCCTCCACCTGCAGCCCCGCGGCCCCCGCGCCCCGCGGGACCCGGACGGCGACGACGGGGGAATGTGGCGCTGGA
TCCGGCAGCAGCTGATAGATCAGATACTGATTCATCAGCAAATTGAACTTCTGGAAGTTTTAACAGGTTTTGAAACTAATAACAAATATG
AAATTAAGAACAGCTTTGGACAGAGGGTTTACTTTGCAGCGGAAGATACTGATTGCTGTACCCGAAATTGCTGTGGGCCATCTAGACCTT
TTACCTTGAGGATTATTGATAATATGGGTCAAGAAGTCATAACTCTGGAGAGACCACTAAGATGTAGCAGCTGTTGTTGTCCCTGCTGCC
TTCAGGAGATAGAAATCCAAGCTCCTCCTGGTGTACCAATAGGTTATGTTATTCAGACTTGGCACCCATGTCTACCAAAGTTTACAATTC
AAAATGAGAAAAGAGAGGATGTACTAAAAATAAGTGGTCCATGTGTTGTGTGCAGCTGTTGTGGAGATGTTGATTTTGAGATTAAATCTC
TTGATGAACAGTGTGTGGTTGGCAAAATTTCCAAGCACTGGACTGGAATTTTGAGAGAGGCATTTACAGACGCTGATAACTTTGGAATCC
AGTTCCCTTTAGACCTTGATGTTAAAATGAAAGCTGTAATGATTGGTGCCTGTTTCCTCATTGACTTCATGTTTTTTGAAAGCACTGGCA
GCCAGGAACAAAAATCAGGAGTGTGGTAGTGGATTAGTGAAAGTCTCCTCAGGAAATCTGAAGTCTGTATATTGATTGAGACTATCTAAA
CTCATACCTGTATGAATTAAGCTGTAAGGCCTGTAGCTCTGGTTGTATACTTTTGCTTTTCAAATTATAGTTTATCTTCTGTATAACTGA
TTTATAAAGGTTTTTGTACATTTTTTAATACTCATTGTCAATTTGAGAAAAAGGACATATGAGTTTTTGCATTTATTAATGAAACTTCCT
TTGAAAAACTGCTTTGAATTATGATCTCTGATTCATTGTCCATTTTACTACCAAATATTAACTAAGGCCTTATTAATTTTTATATAAATT
ATATCTTGTCCTATTAAATCTAGTTACAATTTATTTCATGCATAAGAGCTAATGTTATTTTGCAAATGCCATATATTCAAAAAAGCTCAA
AGATAATTTTCTTTACTATTATGTTCAAATAATATTCAATATGCATATTATCTTTAAAAAGTTAAATGTTTTTTTAATCTTCAAGAAATC
ATGCTACACTTAACTTCTCCTAGAAGCTAATCTATACCATAATATTTTCATATTCACAAGATATTAAATTACCAATTTTCAAATTATTGT
TAGTAAAGAACAAAATGATTCTCTCCCAAAGAAAGACACATTTTAAATACTCCTTCACTCTAAAACTCTGGTATTATAACTTTTGAAAGT
TAATATTTCTACATGAAATGTTTAGCTCTTACACTCTATCCTTCCTAGAAAATGGTAATTGAGATTACTCAGATATTAATTAAATACAAT

>In-frame_ENST00000493826_ENST00000342435_TCGA-BR-7901_ATP11B_chr3_182511574_+_PLSCR1_chr3_146243434_length(amino acids)=241AA_start in transcript=203_stop in transcript=928
MQPRGPRAPRDPDGDDGGMWRWIRQQLIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDN
MGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVG

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Fusion Gene PPI Analysis for ATP11B-PLSCR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePLSCR1chr3:182511574chr3:146243434ENST000003424353999_290104.0319.0hepatitis C virus E2 glycoprotein


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP11B-PLSCR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP11B-PLSCR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLSCR1C0021400Influenza1CTD_human
TgenePLSCR1C0023893Liver Cirrhosis, Experimental1CTD_human