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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RYK-RABL3 (FusionGDB2 ID:78302)

Fusion Gene Summary for RYK-RABL3

check button Fusion gene summary
Fusion gene informationFusion gene name: RYK-RABL3
Fusion gene ID: 78302
HgeneTgene
Gene symbol

RYK

RABL3

Gene ID

6259

285282

Gene namereceptor like tyrosine kinaseRAB, member of RAS oncogene family like 3
SynonymsD3S3195|JTK5|JTK5A|RYK1PNCA5
Cytomap

3q22.2

3q13.33

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase RYKJTK5A protein tyrosine kinasehydroxyaryl-protein kinaserab-like protein 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296084, ENST00000427044, 
ENST00000484106, 		ENST00000273375, 
ENST00000491398, ENST00000483733, 
Fusion gene scores* DoF score9 X 10 X 6=5403 X 3 X 3=27
# samples 124
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RYK [Title/Abstract] AND RABL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRYK(133913926)-RABL3(120417420), # samples:2
RYK(133921574)-RABL3(120417420), # samples:2
Anticipated loss of major functional domain due to fusion event.RYK-RABL3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
RYK-RABL3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRYK

GO:0006468

protein phosphorylation

10454588

HgeneRYK

GO:0043410

positive regulation of MAPK cascade

10454588


check buttonFusion gene breakpoints across RYK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RABL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0DL-01ARYKchr3

133913926

-RABL3chr3

120417420

-
ChimerDB4BRCATCGA-BH-A0DLRYKchr3

133921573

-RABL3chr3

120417420

-
ChimerDB4BRCATCGA-BH-A0DL-01ARYKchr3

133913926

-RABL3chr3

120417420

-
ChimerDB4BRCATCGA-BH-A0DL-01ARYKchr3

133921574

-RABL3chr3

120417420

-
ChimerDB4BRCATCGA-BH-A0DL-01ARYKchr3

133921574

-RABL3chr3

120417420

-


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Fusion Gene ORF analysis for RYK-RABL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296084ENST00000273375RYKchr3

133913926

-RABL3chr3

120417420

-
5CDS-5UTRENST00000296084ENST00000491398RYKchr3

133913926

-RABL3chr3

120417420

-
5CDS-5UTRENST00000296084ENST00000483733RYKchr3

133913926

-RABL3chr3

120417420

-
Frame-shiftENST00000427044ENST00000273375RYKchr3

133913926

-RABL3chr3

120417420

-
5CDS-5UTRENST00000427044ENST00000491398RYKchr3

133913926

-RABL3chr3

120417420

-
5CDS-5UTRENST00000427044ENST00000483733RYKchr3

133913926

-RABL3chr3

120417420

-
intron-3CDSENST00000484106ENST00000273375RYKchr3

133913926

-RABL3chr3

120417420

-
intron-5UTRENST00000484106ENST00000491398RYKchr3

133913926

-RABL3chr3

120417420

-
intron-5UTRENST00000484106ENST00000483733RYKchr3

133913926

-RABL3chr3

120417420

-
In-frameENST00000296084ENST00000273375RYKchr3

133921573

-RABL3chr3

120417420

-
5CDS-5UTRENST00000296084ENST00000491398RYKchr3

133921573

-RABL3chr3

120417420

-
5CDS-5UTRENST00000296084ENST00000483733RYKchr3

133921573

-RABL3chr3

120417420

-
In-frameENST00000427044ENST00000273375RYKchr3

133921573

-RABL3chr3

120417420

-
5CDS-5UTRENST00000427044ENST00000491398RYKchr3

133921573

-RABL3chr3

120417420

-
5CDS-5UTRENST00000427044ENST00000483733RYKchr3

133921573

-RABL3chr3

120417420

-
intron-3CDSENST00000484106ENST00000273375RYKchr3

133921573

-RABL3chr3

120417420

-
intron-5UTRENST00000484106ENST00000491398RYKchr3

133921573

-RABL3chr3

120417420

-
intron-5UTRENST00000484106ENST00000483733RYKchr3

133921573

-RABL3chr3

120417420

-
In-frameENST00000296084ENST00000273375RYKchr3

133921574

-RABL3chr3

120417420

-
5CDS-5UTRENST00000296084ENST00000491398RYKchr3

133921574

-RABL3chr3

120417420

-
5CDS-5UTRENST00000296084ENST00000483733RYKchr3

133921574

-RABL3chr3

120417420

-
In-frameENST00000427044ENST00000273375RYKchr3

133921574

-RABL3chr3

120417420

-
5CDS-5UTRENST00000427044ENST00000491398RYKchr3

133921574

-RABL3chr3

120417420

-
5CDS-5UTRENST00000427044ENST00000483733RYKchr3

133921574

-RABL3chr3

120417420

-
intron-3CDSENST00000484106ENST00000273375RYKchr3

133921574

-RABL3chr3

120417420

-
intron-5UTRENST00000484106ENST00000491398RYKchr3

133921574

-RABL3chr3

120417420

-
intron-5UTRENST00000484106ENST00000483733RYKchr3

133921574

-RABL3chr3

120417420

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296084RYKchr3133921573-ENST00000273375RABL3chr3120417420-4252782151109364
ENST00000427044RYKchr3133921573-ENST00000273375RABL3chr3120417420-4293823741150358
ENST00000296084RYKchr3133921574-ENST00000273375RABL3chr3120417420-4252782151109364
ENST00000427044RYKchr3133921574-ENST00000273375RABL3chr3120417420-4293823741150358

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296084ENST00000273375RYKchr3133921573-RABL3chr3120417420-0.0015951970.9984048
ENST00000427044ENST00000273375RYKchr3133921573-RABL3chr3120417420-0.0015754720.99842453
ENST00000296084ENST00000273375RYKchr3133921574-RABL3chr3120417420-0.0015951970.9984048
ENST00000427044ENST00000273375RYKchr3133921574-RABL3chr3120417420-0.0015754720.99842453

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Fusion Genomic Features for RYK-RABL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RYK-RABL3


check button Go to

FGviewer for the breakpoints of chr3:133921573-chr3:120417420

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-71624_53260.6666666666667609.0Compositional biasPro-rich
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-71624_53260.6666666666667609.0Compositional biasPro-rich
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-71666_194260.6666666666667609.0DomainWIF
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-71666_194260.6666666666667609.0DomainWIF
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-71626_227260.6666666666667609.0Topological domainExtracellular
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-71626_227260.6666666666667609.0Topological domainExtracellular
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-716228_248260.6666666666667609.0TransmembraneHelical
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-716228_248260.6666666666667609.0TransmembraneHelical
TgeneRABL3chr3:133921573chr3:120417420ENST0000027337538148_150127.66666666666667237.0Nucleotide bindingGTP
TgeneRABL3chr3:133921573chr3:120417420ENST0000027337538179_180127.66666666666667237.0Nucleotide bindingGTP
TgeneRABL3chr3:133921574chr3:120417420ENST0000027337538148_150127.66666666666667237.0Nucleotide bindingGTP
TgeneRABL3chr3:133921574chr3:120417420ENST0000027337538179_180127.66666666666667237.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-716330_603260.6666666666667609.0DomainProtein kinase
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-716330_603260.6666666666667609.0DomainProtein kinase
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-716336_344260.6666666666667609.0Nucleotide bindingATP
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-716336_344260.6666666666667609.0Nucleotide bindingATP
HgeneRYKchr3:133921573chr3:120417420ENST00000296084-716249_607260.6666666666667609.0Topological domainCytoplasmic
HgeneRYKchr3:133921574chr3:120417420ENST00000296084-716249_607260.6666666666667609.0Topological domainCytoplasmic
TgeneRABL3chr3:133921573chr3:120417420ENST000002733753816_21127.66666666666667237.0Nucleotide bindingGTP
TgeneRABL3chr3:133921574chr3:120417420ENST000002733753816_21127.66666666666667237.0Nucleotide bindingGTP
TgeneRABL3chr3:133921573chr3:120417420ENST00000273375381_236127.66666666666667237.0RegionNote=Small GTPase-like
TgeneRABL3chr3:133921574chr3:120417420ENST00000273375381_236127.66666666666667237.0RegionNote=Small GTPase-like


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Fusion Gene Sequence for RYK-RABL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000296084_ENST00000273375_TCGA-BH-A0DL_RYK_chr3_133921573_-_RABL3_chr3_120417420_length(transcript)=4252nt_BP=782nt
GCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCCCGCGGCAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTG
CTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCGCCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCC
AGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGT
CACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCCTGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAG
CTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCAACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTG
TTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGATACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAAT
TTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGA
ACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTC
GTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTGAACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGAT
AACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATGAAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTG
GCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCACGGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGT
AGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTAATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCA
GGAACATTAAAGAGCCTTCATTATGACTGAATTACACTCATCCTTTGGAAGAGTGAGCAAGCAGTGGCAGTTTTTCACAGCTCATCTTGC
TGTGTTCAATTATTACCATCACAGCCTTTTAACAAAATCATCTTAAAATGCTACCCTTCAGCCTTACCCTTTAATGGAAAAATGAAAGGA
AGTGACAATACGGGAGGTCCAAACTTTGTCCCTGTTCTCTGTGTTCCTTACCTTTCTGTCCCTGTGTATAGATTATGTAAAAGCCTTGTG
TAAATATGAGATGTTGTCAAAATGATGCAGTAAATGAGCAATGACAGTGTACTGCAGAGAAAATTTACTCTTGCCTAGAACTGGAGGGTT
TTTATGGGTCTGTAATTTTCCCACACTCATTGCTGAAAGCTTAATTAAGTACTTCAAAAACGTATCTCCATTGTTTTACCTTCTTGAGGG
GAACGGTCTTGTTAACCAGCCCTGAGTTGTCTACCCCAAACAATCTCTGTCATTTTCAAAGATGCAAAATGGTGTTATTTAATTGTCTCC
ACCATTGTCACACACAGGAATGCCTAATAATAGCAACCCTTGTCTCCCTCTTCTCTCCTTTGCAAATGGCTCAGTGACTGGAAGAGGCGG
ACTAATAGCCAGAGTTAAATATAAATACAAATTAATAATACATAGAGAACAGCAATACCAGAAAAAAAGAATTCTGGTAAAATGATGTGA
AAAATTGACAGCTCCCTCACTCTTAAGGTTGCTGCTATATACAGTCTAGGTTTTCTGTTTGGAAATAGGTAGGGTAAAATCTAAGACCTG
CACAAGGGCAGTGAGAGACATTTACAGCCTCCTCTCTATTTGTTTTTTTAAGGAAAAGTCAACTCCTGAAATGTCCCTTAGCTATAATCA
GAAAACTAAGAATATTATTCTGTGTCAACAATGTATTTATGGAGAGAAGTAAAAATAAGTTCCACAGCAACACATTTACATGAATTATGA
ACTAGGATTCTTGGATTTCATAATCACTCCAAAGCTTTTTGGGGATGGTGTGTGTGTGTGTGTGTGTCCGTAATTGTTCATCATTACTTT
TTTTAACCTATCTTTTTGCTTGCTTAATCTTCTCTGCCCCAGTTCTTCCTGAGTATATGAATTTGATTTCTAAAAACAATTTATTCAACA
CTCTATCACCCGTATTCTCTCTCTGGCTCTGCTGCAGGTCTCTGCACTCCTGATTTTGCTCCATACTTTTAAATAACAATAATAAATATA
CAGTTTTCATTTCTCATTTAAAAAATAGGTGGAAAACACCAAATTCACTTTCTGTTCCATTTTAATTAGGTTTCAGAAGTATCTTGGAAA
TCAAGGTATGCTGCAAGAGGATATTAAAATAAGAATGTTAGAGAGTCCTTTTAGAAAGGCAGTCTTGGGAATTTGGAAAAGGATTTTTAA
AGCAGCTTTCATCAGCTAGACTGTTCTCCAGCCTTTCTTTACTTCCTCTTTGAAAGGACATAGCCCTGGTTTCTTTTTGACACAAAGGAA
AGCTATGCAAATCATGATCTGTATGTAGAATTGGTCACAAGTATGTTGTTGCATAGGCTGTACAGTTGGGAAGTAGAAACCAAATGCTAC
CCAGAGACCTAACCCAATTAAGCTCTTTGTATTTCTCCTTCAAGAAATAAATCTTCCTTCCTTCTTTCTTCCTCTTTCTTTTAATTTTAA
AAAAATTCATCCTGATTTTTTTATTTTCTATCTTATTTAAAAAATAAAAATAGGCCAGGCGCGGTGGCTCACACCTTTAATCCCAACACT
TTGGGAGGCGGGTCGATCACTTGATATCAGGAGTTTGAGACCAGCCTGGCCAACATAGGGAAACCCTGTCTCTACTAAAAATACAAAAAT
TAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCA
GTGAGTCAAGATCGTGTCACTGCACTCCAGCCTAGGTGACAGAGTGAGACTCCAACTAAAAGAAAATAAATAAATAAATATATAAATATA
TAAATAAATAATAAAAGTAAACTATTGCTGATGACTCCAGGGTCAATCTGGAAAAATTAACAGTATTCCTCAACTCCATTACTTTCTGCA
GCCAAGCTTGATTCCTTGAATTATAGTTTTCTAAGAAAAAATAGTTTTTAATAATCTAAGGTAAATTTGTTGCAATTATTAGCAGCAGCA
TAATAAGGCTTTTTGCGCAAATGAATGTTATTAGCTAGAGTTATTCAAAAAAGAATGAAGCACAATTTTTGCTAGGACTTCTTGAGAACT
ATTCATAAAAATGCTTTTAGATAATAAACAAGTATAAATGTCAAAATATTTTTTTAAAAGTATAATTGGCCAGGTGCTGGCTCACGCCTA
TAATCCCAGCACTCTAGGAGACTGAGGCAGGAGGATCACTTGAGCTCGGGAGTTTGAGGCTGCAGTGATTCATGATTGCACCACTGCCTT
CCAGCAGCCTGATGACAGAGTGGGACTCCATCTCTTTACATATGTATATCTTACTCTCTTGATGGGACAAGTTGGTAGAAATAAAGATTT
TTTTTTTCTGTTGTGATTTCGGTGTCTGACCAATTTTCTGACTCATTGTGAAGGTGACCAGATATGAAGGCATATATATGACTACTCCTC
TGTCCCTTAGGTGTATAAGACTTAGCTGGAATCCAACTAAAGATTTGGGCTGGTCTCTCCATCTTAACGTTGATGGGATTCAGGACACAT
AACCCCAAAATATTGCACCCTGTTATTTGAGAAAACTGCAGAAGCAAGGTTTCTCATACCTTCCCCTTACCCCTTCTCCCCTGAAGCAGG
CCATAAACCCTAAGTGACTGTTCCCTGAAGTAGATCATAAAACCTTCATTCCATAGGTACCCTTTATCCTCACAGATACAGAGACACCAA
GAAGAATCTGGACAAATAGGACTTGCTAAGTTCTCCACAGTTTATTACCATTAGATTATGTCCTTTTGTCCTCTGATTATACTTCTGCAT
AAGACTGTACATAAAAATACACAAGTTTTCCTATTTCTTTTTTGTCTTCATTTCTGAAGATTCCTGTCATGTAAAACTTACAGTAAATAA

>In-frame_ENST00000296084_ENST00000273375_TCGA-BH-A0DL_RYK_chr3_133921573_-_RABL3_chr3_120417420_length(amino acids)=364AA_start in transcript=15_stop in transcript=1109
MGRPGRSCLPGARGRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALS
FSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLN
FKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDRDYDQEQFADNQIPL
LVIGTKLDQIHETKRHEVLTRTAFLAEDFNPEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLREGNQIPGFPDRKRFGAGTLKS

--------------------------------------------------------------
>In-frame_ENST00000427044_ENST00000273375_TCGA-BH-A0DL_RYK_chr3_133921573_-_RABL3_chr3_120417420_length(transcript)=4293nt_BP=823nt
CGGACGATGCAGCGAGGAGGCGGCGGCGGCGGCGGCCATGCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCC
CGCGGCTGAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTGCTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCG
CCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCCAGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTC
TTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGTCACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCC
TGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAGCTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCA
ACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTGTTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGA
TACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAATTTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTG
AAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGAACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGT
TTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTCGTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTG
AACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGATAACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATG
AAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTGGCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCAC
GGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGTAGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTA
ATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCAGGAACATTAAAGAGCCTTCATTATGACTGAATTACACTCATCCTTTGGA
AGAGTGAGCAAGCAGTGGCAGTTTTTCACAGCTCATCTTGCTGTGTTCAATTATTACCATCACAGCCTTTTAACAAAATCATCTTAAAAT
GCTACCCTTCAGCCTTACCCTTTAATGGAAAAATGAAAGGAAGTGACAATACGGGAGGTCCAAACTTTGTCCCTGTTCTCTGTGTTCCTT
ACCTTTCTGTCCCTGTGTATAGATTATGTAAAAGCCTTGTGTAAATATGAGATGTTGTCAAAATGATGCAGTAAATGAGCAATGACAGTG
TACTGCAGAGAAAATTTACTCTTGCCTAGAACTGGAGGGTTTTTATGGGTCTGTAATTTTCCCACACTCATTGCTGAAAGCTTAATTAAG
TACTTCAAAAACGTATCTCCATTGTTTTACCTTCTTGAGGGGAACGGTCTTGTTAACCAGCCCTGAGTTGTCTACCCCAAACAATCTCTG
TCATTTTCAAAGATGCAAAATGGTGTTATTTAATTGTCTCCACCATTGTCACACACAGGAATGCCTAATAATAGCAACCCTTGTCTCCCT
CTTCTCTCCTTTGCAAATGGCTCAGTGACTGGAAGAGGCGGACTAATAGCCAGAGTTAAATATAAATACAAATTAATAATACATAGAGAA
CAGCAATACCAGAAAAAAAGAATTCTGGTAAAATGATGTGAAAAATTGACAGCTCCCTCACTCTTAAGGTTGCTGCTATATACAGTCTAG
GTTTTCTGTTTGGAAATAGGTAGGGTAAAATCTAAGACCTGCACAAGGGCAGTGAGAGACATTTACAGCCTCCTCTCTATTTGTTTTTTT
AAGGAAAAGTCAACTCCTGAAATGTCCCTTAGCTATAATCAGAAAACTAAGAATATTATTCTGTGTCAACAATGTATTTATGGAGAGAAG
TAAAAATAAGTTCCACAGCAACACATTTACATGAATTATGAACTAGGATTCTTGGATTTCATAATCACTCCAAAGCTTTTTGGGGATGGT
GTGTGTGTGTGTGTGTGTCCGTAATTGTTCATCATTACTTTTTTTAACCTATCTTTTTGCTTGCTTAATCTTCTCTGCCCCAGTTCTTCC
TGAGTATATGAATTTGATTTCTAAAAACAATTTATTCAACACTCTATCACCCGTATTCTCTCTCTGGCTCTGCTGCAGGTCTCTGCACTC
CTGATTTTGCTCCATACTTTTAAATAACAATAATAAATATACAGTTTTCATTTCTCATTTAAAAAATAGGTGGAAAACACCAAATTCACT
TTCTGTTCCATTTTAATTAGGTTTCAGAAGTATCTTGGAAATCAAGGTATGCTGCAAGAGGATATTAAAATAAGAATGTTAGAGAGTCCT
TTTAGAAAGGCAGTCTTGGGAATTTGGAAAAGGATTTTTAAAGCAGCTTTCATCAGCTAGACTGTTCTCCAGCCTTTCTTTACTTCCTCT
TTGAAAGGACATAGCCCTGGTTTCTTTTTGACACAAAGGAAAGCTATGCAAATCATGATCTGTATGTAGAATTGGTCACAAGTATGTTGT
TGCATAGGCTGTACAGTTGGGAAGTAGAAACCAAATGCTACCCAGAGACCTAACCCAATTAAGCTCTTTGTATTTCTCCTTCAAGAAATA
AATCTTCCTTCCTTCTTTCTTCCTCTTTCTTTTAATTTTAAAAAAATTCATCCTGATTTTTTTATTTTCTATCTTATTTAAAAAATAAAA
ATAGGCCAGGCGCGGTGGCTCACACCTTTAATCCCAACACTTTGGGAGGCGGGTCGATCACTTGATATCAGGAGTTTGAGACCAGCCTGG
CCAACATAGGGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCT
GAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAGTCAAGATCGTGTCACTGCACTCCAGCCTAGGTGACAGAGTGAGA
CTCCAACTAAAAGAAAATAAATAAATAAATATATAAATATATAAATAAATAATAAAAGTAAACTATTGCTGATGACTCCAGGGTCAATCT
GGAAAAATTAACAGTATTCCTCAACTCCATTACTTTCTGCAGCCAAGCTTGATTCCTTGAATTATAGTTTTCTAAGAAAAAATAGTTTTT
AATAATCTAAGGTAAATTTGTTGCAATTATTAGCAGCAGCATAATAAGGCTTTTTGCGCAAATGAATGTTATTAGCTAGAGTTATTCAAA
AAAGAATGAAGCACAATTTTTGCTAGGACTTCTTGAGAACTATTCATAAAAATGCTTTTAGATAATAAACAAGTATAAATGTCAAAATAT
TTTTTTAAAAGTATAATTGGCCAGGTGCTGGCTCACGCCTATAATCCCAGCACTCTAGGAGACTGAGGCAGGAGGATCACTTGAGCTCGG
GAGTTTGAGGCTGCAGTGATTCATGATTGCACCACTGCCTTCCAGCAGCCTGATGACAGAGTGGGACTCCATCTCTTTACATATGTATAT
CTTACTCTCTTGATGGGACAAGTTGGTAGAAATAAAGATTTTTTTTTTCTGTTGTGATTTCGGTGTCTGACCAATTTTCTGACTCATTGT
GAAGGTGACCAGATATGAAGGCATATATATGACTACTCCTCTGTCCCTTAGGTGTATAAGACTTAGCTGGAATCCAACTAAAGATTTGGG
CTGGTCTCTCCATCTTAACGTTGATGGGATTCAGGACACATAACCCCAAAATATTGCACCCTGTTATTTGAGAAAACTGCAGAAGCAAGG
TTTCTCATACCTTCCCCTTACCCCTTCTCCCCTGAAGCAGGCCATAAACCCTAAGTGACTGTTCCCTGAAGTAGATCATAAAACCTTCAT
TCCATAGGTACCCTTTATCCTCACAGATACAGAGACACCAAGAAGAATCTGGACAAATAGGACTTGCTAAGTTCTCCACAGTTTATTACC
ATTAGATTATGTCCTTTTGTCCTCTGATTATACTTCTGCATAAGACTGTACATAAAAATACACAAGTTTTCCTATTTCTTTTTTGTCTTC

>In-frame_ENST00000427044_ENST00000273375_TCGA-BH-A0DL_RYK_chr3_133921573_-_RABL3_chr3_120417420_length(amino acids)=358AA_start in transcript=74_stop in transcript=1150
MPPGGPRLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVP
SETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKM
CYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDRDYDQEQFADNQIPLLVIGTK

--------------------------------------------------------------
>In-frame_ENST00000296084_ENST00000273375_TCGA-BH-A0DL-01A_RYK_chr3_133921574_-_RABL3_chr3_120417420_length(transcript)=4252nt_BP=782nt
GCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCCCGCGGCAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTG
CTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCGCCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCC
AGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTCTTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGT
CACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCCTGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAG
CTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCAACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTG
TTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGATACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAAT
TTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTGAAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGA
ACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGTTTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTC
GTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTGAACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGAT
AACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATGAAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTG
GCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCACGGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGT
AGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTAATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCA
GGAACATTAAAGAGCCTTCATTATGACTGAATTACACTCATCCTTTGGAAGAGTGAGCAAGCAGTGGCAGTTTTTCACAGCTCATCTTGC
TGTGTTCAATTATTACCATCACAGCCTTTTAACAAAATCATCTTAAAATGCTACCCTTCAGCCTTACCCTTTAATGGAAAAATGAAAGGA
AGTGACAATACGGGAGGTCCAAACTTTGTCCCTGTTCTCTGTGTTCCTTACCTTTCTGTCCCTGTGTATAGATTATGTAAAAGCCTTGTG
TAAATATGAGATGTTGTCAAAATGATGCAGTAAATGAGCAATGACAGTGTACTGCAGAGAAAATTTACTCTTGCCTAGAACTGGAGGGTT
TTTATGGGTCTGTAATTTTCCCACACTCATTGCTGAAAGCTTAATTAAGTACTTCAAAAACGTATCTCCATTGTTTTACCTTCTTGAGGG
GAACGGTCTTGTTAACCAGCCCTGAGTTGTCTACCCCAAACAATCTCTGTCATTTTCAAAGATGCAAAATGGTGTTATTTAATTGTCTCC
ACCATTGTCACACACAGGAATGCCTAATAATAGCAACCCTTGTCTCCCTCTTCTCTCCTTTGCAAATGGCTCAGTGACTGGAAGAGGCGG
ACTAATAGCCAGAGTTAAATATAAATACAAATTAATAATACATAGAGAACAGCAATACCAGAAAAAAAGAATTCTGGTAAAATGATGTGA
AAAATTGACAGCTCCCTCACTCTTAAGGTTGCTGCTATATACAGTCTAGGTTTTCTGTTTGGAAATAGGTAGGGTAAAATCTAAGACCTG
CACAAGGGCAGTGAGAGACATTTACAGCCTCCTCTCTATTTGTTTTTTTAAGGAAAAGTCAACTCCTGAAATGTCCCTTAGCTATAATCA
GAAAACTAAGAATATTATTCTGTGTCAACAATGTATTTATGGAGAGAAGTAAAAATAAGTTCCACAGCAACACATTTACATGAATTATGA
ACTAGGATTCTTGGATTTCATAATCACTCCAAAGCTTTTTGGGGATGGTGTGTGTGTGTGTGTGTGTCCGTAATTGTTCATCATTACTTT
TTTTAACCTATCTTTTTGCTTGCTTAATCTTCTCTGCCCCAGTTCTTCCTGAGTATATGAATTTGATTTCTAAAAACAATTTATTCAACA
CTCTATCACCCGTATTCTCTCTCTGGCTCTGCTGCAGGTCTCTGCACTCCTGATTTTGCTCCATACTTTTAAATAACAATAATAAATATA
CAGTTTTCATTTCTCATTTAAAAAATAGGTGGAAAACACCAAATTCACTTTCTGTTCCATTTTAATTAGGTTTCAGAAGTATCTTGGAAA
TCAAGGTATGCTGCAAGAGGATATTAAAATAAGAATGTTAGAGAGTCCTTTTAGAAAGGCAGTCTTGGGAATTTGGAAAAGGATTTTTAA
AGCAGCTTTCATCAGCTAGACTGTTCTCCAGCCTTTCTTTACTTCCTCTTTGAAAGGACATAGCCCTGGTTTCTTTTTGACACAAAGGAA
AGCTATGCAAATCATGATCTGTATGTAGAATTGGTCACAAGTATGTTGTTGCATAGGCTGTACAGTTGGGAAGTAGAAACCAAATGCTAC
CCAGAGACCTAACCCAATTAAGCTCTTTGTATTTCTCCTTCAAGAAATAAATCTTCCTTCCTTCTTTCTTCCTCTTTCTTTTAATTTTAA
AAAAATTCATCCTGATTTTTTTATTTTCTATCTTATTTAAAAAATAAAAATAGGCCAGGCGCGGTGGCTCACACCTTTAATCCCAACACT
TTGGGAGGCGGGTCGATCACTTGATATCAGGAGTTTGAGACCAGCCTGGCCAACATAGGGAAACCCTGTCTCTACTAAAAATACAAAAAT
TAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCA
GTGAGTCAAGATCGTGTCACTGCACTCCAGCCTAGGTGACAGAGTGAGACTCCAACTAAAAGAAAATAAATAAATAAATATATAAATATA
TAAATAAATAATAAAAGTAAACTATTGCTGATGACTCCAGGGTCAATCTGGAAAAATTAACAGTATTCCTCAACTCCATTACTTTCTGCA
GCCAAGCTTGATTCCTTGAATTATAGTTTTCTAAGAAAAAATAGTTTTTAATAATCTAAGGTAAATTTGTTGCAATTATTAGCAGCAGCA
TAATAAGGCTTTTTGCGCAAATGAATGTTATTAGCTAGAGTTATTCAAAAAAGAATGAAGCACAATTTTTGCTAGGACTTCTTGAGAACT
ATTCATAAAAATGCTTTTAGATAATAAACAAGTATAAATGTCAAAATATTTTTTTAAAAGTATAATTGGCCAGGTGCTGGCTCACGCCTA
TAATCCCAGCACTCTAGGAGACTGAGGCAGGAGGATCACTTGAGCTCGGGAGTTTGAGGCTGCAGTGATTCATGATTGCACCACTGCCTT
CCAGCAGCCTGATGACAGAGTGGGACTCCATCTCTTTACATATGTATATCTTACTCTCTTGATGGGACAAGTTGGTAGAAATAAAGATTT
TTTTTTTCTGTTGTGATTTCGGTGTCTGACCAATTTTCTGACTCATTGTGAAGGTGACCAGATATGAAGGCATATATATGACTACTCCTC
TGTCCCTTAGGTGTATAAGACTTAGCTGGAATCCAACTAAAGATTTGGGCTGGTCTCTCCATCTTAACGTTGATGGGATTCAGGACACAT
AACCCCAAAATATTGCACCCTGTTATTTGAGAAAACTGCAGAAGCAAGGTTTCTCATACCTTCCCCTTACCCCTTCTCCCCTGAAGCAGG
CCATAAACCCTAAGTGACTGTTCCCTGAAGTAGATCATAAAACCTTCATTCCATAGGTACCCTTTATCCTCACAGATACAGAGACACCAA
GAAGAATCTGGACAAATAGGACTTGCTAAGTTCTCCACAGTTTATTACCATTAGATTATGTCCTTTTGTCCTCTGATTATACTTCTGCAT
AAGACTGTACATAAAAATACACAAGTTTTCCTATTTCTTTTTTGTCTTCATTTCTGAAGATTCCTGTCATGTAAAACTTACAGTAAATAA

>In-frame_ENST00000296084_ENST00000273375_TCGA-BH-A0DL-01A_RYK_chr3_133921574_-_RABL3_chr3_120417420_length(amino acids)=364AA_start in transcript=15_stop in transcript=1109
MGRPGRSCLPGARGRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALS
FSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLN
FKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDRDYDQEQFADNQIPL
LVIGTKLDQIHETKRHEVLTRTAFLAEDFNPEEINLDCTNPRYLAAGSSNAVKLSRFFDKVIEKRYFLREGNQIPGFPDRKRFGAGTLKS

--------------------------------------------------------------
>In-frame_ENST00000427044_ENST00000273375_TCGA-BH-A0DL-01A_RYK_chr3_133921574_-_RABL3_chr3_120417420_length(transcript)=4293nt_BP=823nt
CGGACGATGCAGCGAGGAGGCGGCGGCGGCGGCGGCCATGCGTGGGCGGCGCGGCTGGGGCGGCCGGGCCGGAGTTGCCTCCCGGGGGCC
CGCGGCTGAGGGCCCCGCCGCCGCCGCCGCTGCTGCTTCTGCTTGCGCTGTTGCCGCTGCTGCCCGCGCCTGGCGCTGCCGCCGCCCCCG
CCCCGCGGCCCCCGGAGCTGCAGTCGGCTTCCGCGGGGCCCAGCGTGAGTCTCTACCTGAGCGAGGACGAGGTGCGCCGGCTGATCGGTC
TTGATGCAGAACTTTATTATGTGAGAAATGACCTTATTAGTCACTACGCTCTATCCTTTAGTCTGTTAGTACCCAGTGAGACAAATTTCC
TGCACTTCACCTGGCATGCGAAGTCCAAGGTTGAATATAAGCTGGGATTCCAAGTGGACAATGTTTTGGCAATGGATATGCCCCAGGTCA
ACATTTCTGTTCAGGGGGAAGTTCCACGCACTTTATCAGTGTTTCGGGTAGAGCTTTCCTGTACTGGCAAAGTAGATTCTGAAGTTATGA
TACTAATGCAGCTCAACTTGACAGTAAATTCTTCAAAAAATTTTACCGTCTTAAATTTTAAACGAAGGAAAATGTGCTACAAAAAACTTG
AAGAAGTAAAAACTTCAGCCTTGGACAAAAACACTAGCAGAACTATTTATGATCCTGTACATGCAGCTCCAACCACTTCTACGCGTGTGT
TTTATATTAGTGTAGGGGTTTGTTGTGCAGTAATATTTCTCGTAGCAATAATATTAGCTGTTTTGCACCTTCATAGTATGAAAAGGATTG
AACTGGATGACAGGGATTATGATCAAGAACAGTTTGCTGATAACCAAATACCACTGTTGGTAATAGGGACTAAACTGGACCAGATTCATG
AAACAAAGCGCCATGAAGTTTTAACTAGGACTGCTTTCCTGGCTGAGGATTTCAATCCAGAAGAAATTAATTTGGACTGCACAAATCCAC
GGTACTTAGCTGCAGGTTCTTCCAATGCTGTCAAGCTCAGTAGGTTTTTTGATAAGGTCATAGAGAAGAGATACTTTTTAAGAGAAGGTA
ATCAGATTCCAGGCTTTCCTGATCGGAAAAGATTTGGGGCAGGAACATTAAAGAGCCTTCATTATGACTGAATTACACTCATCCTTTGGA
AGAGTGAGCAAGCAGTGGCAGTTTTTCACAGCTCATCTTGCTGTGTTCAATTATTACCATCACAGCCTTTTAACAAAATCATCTTAAAAT
GCTACCCTTCAGCCTTACCCTTTAATGGAAAAATGAAAGGAAGTGACAATACGGGAGGTCCAAACTTTGTCCCTGTTCTCTGTGTTCCTT
ACCTTTCTGTCCCTGTGTATAGATTATGTAAAAGCCTTGTGTAAATATGAGATGTTGTCAAAATGATGCAGTAAATGAGCAATGACAGTG
TACTGCAGAGAAAATTTACTCTTGCCTAGAACTGGAGGGTTTTTATGGGTCTGTAATTTTCCCACACTCATTGCTGAAAGCTTAATTAAG
TACTTCAAAAACGTATCTCCATTGTTTTACCTTCTTGAGGGGAACGGTCTTGTTAACCAGCCCTGAGTTGTCTACCCCAAACAATCTCTG
TCATTTTCAAAGATGCAAAATGGTGTTATTTAATTGTCTCCACCATTGTCACACACAGGAATGCCTAATAATAGCAACCCTTGTCTCCCT
CTTCTCTCCTTTGCAAATGGCTCAGTGACTGGAAGAGGCGGACTAATAGCCAGAGTTAAATATAAATACAAATTAATAATACATAGAGAA
CAGCAATACCAGAAAAAAAGAATTCTGGTAAAATGATGTGAAAAATTGACAGCTCCCTCACTCTTAAGGTTGCTGCTATATACAGTCTAG
GTTTTCTGTTTGGAAATAGGTAGGGTAAAATCTAAGACCTGCACAAGGGCAGTGAGAGACATTTACAGCCTCCTCTCTATTTGTTTTTTT
AAGGAAAAGTCAACTCCTGAAATGTCCCTTAGCTATAATCAGAAAACTAAGAATATTATTCTGTGTCAACAATGTATTTATGGAGAGAAG
TAAAAATAAGTTCCACAGCAACACATTTACATGAATTATGAACTAGGATTCTTGGATTTCATAATCACTCCAAAGCTTTTTGGGGATGGT
GTGTGTGTGTGTGTGTGTCCGTAATTGTTCATCATTACTTTTTTTAACCTATCTTTTTGCTTGCTTAATCTTCTCTGCCCCAGTTCTTCC
TGAGTATATGAATTTGATTTCTAAAAACAATTTATTCAACACTCTATCACCCGTATTCTCTCTCTGGCTCTGCTGCAGGTCTCTGCACTC
CTGATTTTGCTCCATACTTTTAAATAACAATAATAAATATACAGTTTTCATTTCTCATTTAAAAAATAGGTGGAAAACACCAAATTCACT
TTCTGTTCCATTTTAATTAGGTTTCAGAAGTATCTTGGAAATCAAGGTATGCTGCAAGAGGATATTAAAATAAGAATGTTAGAGAGTCCT
TTTAGAAAGGCAGTCTTGGGAATTTGGAAAAGGATTTTTAAAGCAGCTTTCATCAGCTAGACTGTTCTCCAGCCTTTCTTTACTTCCTCT
TTGAAAGGACATAGCCCTGGTTTCTTTTTGACACAAAGGAAAGCTATGCAAATCATGATCTGTATGTAGAATTGGTCACAAGTATGTTGT
TGCATAGGCTGTACAGTTGGGAAGTAGAAACCAAATGCTACCCAGAGACCTAACCCAATTAAGCTCTTTGTATTTCTCCTTCAAGAAATA
AATCTTCCTTCCTTCTTTCTTCCTCTTTCTTTTAATTTTAAAAAAATTCATCCTGATTTTTTTATTTTCTATCTTATTTAAAAAATAAAA
ATAGGCCAGGCGCGGTGGCTCACACCTTTAATCCCAACACTTTGGGAGGCGGGTCGATCACTTGATATCAGGAGTTTGAGACCAGCCTGG
CCAACATAGGGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCCTGGTGGCACGCGCCTGTAATCCCAGCTACTTGGGAGGCT
GAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAGTCAAGATCGTGTCACTGCACTCCAGCCTAGGTGACAGAGTGAGA
CTCCAACTAAAAGAAAATAAATAAATAAATATATAAATATATAAATAAATAATAAAAGTAAACTATTGCTGATGACTCCAGGGTCAATCT
GGAAAAATTAACAGTATTCCTCAACTCCATTACTTTCTGCAGCCAAGCTTGATTCCTTGAATTATAGTTTTCTAAGAAAAAATAGTTTTT
AATAATCTAAGGTAAATTTGTTGCAATTATTAGCAGCAGCATAATAAGGCTTTTTGCGCAAATGAATGTTATTAGCTAGAGTTATTCAAA
AAAGAATGAAGCACAATTTTTGCTAGGACTTCTTGAGAACTATTCATAAAAATGCTTTTAGATAATAAACAAGTATAAATGTCAAAATAT
TTTTTTAAAAGTATAATTGGCCAGGTGCTGGCTCACGCCTATAATCCCAGCACTCTAGGAGACTGAGGCAGGAGGATCACTTGAGCTCGG
GAGTTTGAGGCTGCAGTGATTCATGATTGCACCACTGCCTTCCAGCAGCCTGATGACAGAGTGGGACTCCATCTCTTTACATATGTATAT
CTTACTCTCTTGATGGGACAAGTTGGTAGAAATAAAGATTTTTTTTTTCTGTTGTGATTTCGGTGTCTGACCAATTTTCTGACTCATTGT
GAAGGTGACCAGATATGAAGGCATATATATGACTACTCCTCTGTCCCTTAGGTGTATAAGACTTAGCTGGAATCCAACTAAAGATTTGGG
CTGGTCTCTCCATCTTAACGTTGATGGGATTCAGGACACATAACCCCAAAATATTGCACCCTGTTATTTGAGAAAACTGCAGAAGCAAGG
TTTCTCATACCTTCCCCTTACCCCTTCTCCCCTGAAGCAGGCCATAAACCCTAAGTGACTGTTCCCTGAAGTAGATCATAAAACCTTCAT
TCCATAGGTACCCTTTATCCTCACAGATACAGAGACACCAAGAAGAATCTGGACAAATAGGACTTGCTAAGTTCTCCACAGTTTATTACC
ATTAGATTATGTCCTTTTGTCCTCTGATTATACTTCTGCATAAGACTGTACATAAAAATACACAAGTTTTCCTATTTCTTTTTTGTCTTC

>In-frame_ENST00000427044_ENST00000273375_TCGA-BH-A0DL-01A_RYK_chr3_133921574_-_RABL3_chr3_120417420_length(amino acids)=358AA_start in transcript=74_stop in transcript=1150
MPPGGPRLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVP
SETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKM
CYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDRDYDQEQFADNQIPLLVIGTK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RYK-RABL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RYK-RABL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RYK-RABL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRYKC0008925Cleft Palate1CTD_human
HgeneRYKC0043094Weight Gain1CTD_human
HgeneRYKC0376634Craniofacial Abnormalities1CTD_human
HgeneRYKC1837218Cleft palate, isolated1CTD_human
TgeneRABL3C0030297Pancreatic Neoplasm1CTD_human
TgeneRABL3C0346647Malignant neoplasm of pancreas1CTD_human
TgeneRABL3C2931038Pancreatic carcinoma, familial1GENOMICS_ENGLAND