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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RYR2-MTR (FusionGDB2 ID:78318) |
Fusion Gene Summary for RYR2-MTR |
Fusion gene summary |
Fusion gene information | Fusion gene name: RYR2-MTR | Fusion gene ID: 78318 | Hgene | Tgene | Gene symbol | RYR2 | MTR | Gene ID | 6262 | 4548 |
Gene name | ryanodine receptor 2 | 5-methyltetrahydrofolate-homocysteine methyltransferase | |
Synonyms | ARVC2|ARVD2|RYR-2|RyR|VTSIP | HMAG|MS|cblG | |
Cytomap | 1q43 | 1q43 | |
Type of gene | protein-coding | protein-coding | |
Description | ryanodine receptor 2cardiac muscle ryanodine receptor-calcium release channelcardiac-type ryanodine receptorislet-type ryanodine receptorkidney-type ryanodine receptorryanodine receptor 2 (cardiac)type 2 ryanodine receptor | methionine synthase5-methyltetrahydrofolate-homocysteine methyltransferase 1cobalamin-dependent methionine synthasevitamin-B12 dependent methionine synthase | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | . | Q9UBK8 | |
Ensembl transtripts involved in fusion gene | ENST00000366574, ENST00000360064, ENST00000542537, ENST00000609119, | ENST00000366577, ENST00000418145, ENST00000535889, ENST00000470570, | |
Fusion gene scores | * DoF score | 10 X 11 X 5=550 | 5 X 5 X 2=50 |
# samples | 11 | 5 | |
** MAII score | log2(11/550*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
Context | PubMed: RYR2 [Title/Abstract] AND MTR [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RYR2(237551483)-MTR(237044055), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RYR2 | GO:0005513 | detection of calcium ion | 10830164 |
Hgene | RYR2 | GO:0006816 | calcium ion transport | 17921453 |
Hgene | RYR2 | GO:0031000 | response to caffeine | 17921453 |
Hgene | RYR2 | GO:0035584 | calcium-mediated signaling using intracellular calcium source | 17921453 |
Hgene | RYR2 | GO:0051209 | release of sequestered calcium ion into cytosol | 12443530|17921453 |
Hgene | RYR2 | GO:0051284 | positive regulation of sequestering of calcium ion | 12443530|12919952 |
Hgene | RYR2 | GO:0051775 | response to redox state | 19226252 |
Hgene | RYR2 | GO:0060402 | calcium ion transport into cytosol | 17921453 |
Hgene | RYR2 | GO:0071313 | cellular response to caffeine | 12919952 |
Hgene | RYR2 | GO:0072599 | establishment of protein localization to endoplasmic reticulum | 12443530 |
Hgene | RYR2 | GO:1901896 | positive regulation of calcium-transporting ATPase activity | 12443530 |
Fusion gene breakpoints across RYR2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MTR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | ERR315413 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
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Fusion Gene ORF analysis for RYR2-MTR |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000366574 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000366574 | ENST00000418145 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000366574 | ENST00000535889 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000366574 | ENST00000470570 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
In-frame | ENST00000360064 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000360064 | ENST00000418145 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000360064 | ENST00000535889 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000360064 | ENST00000470570 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
In-frame | ENST00000542537 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000542537 | ENST00000418145 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000542537 | ENST00000535889 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
5CDS-intron | ENST00000542537 | ENST00000470570 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
intron-3CDS | ENST00000609119 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
intron-intron | ENST00000609119 | ENST00000418145 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
intron-intron | ENST00000609119 | ENST00000535889 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
intron-intron | ENST00000609119 | ENST00000470570 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000366574 | RYR2 | chr1 | 237551483 | + | ENST00000366577 | MTR | chr1 | 237044055 | + | 8631 | 1090 | 35 | 2293 | 752 |
ENST00000360064 | RYR2 | chr1 | 237551483 | + | ENST00000366577 | MTR | chr1 | 237044055 | + | 8308 | 767 | 0 | 1970 | 656 |
ENST00000542537 | RYR2 | chr1 | 237551483 | + | ENST00000366577 | MTR | chr1 | 237044055 | + | 8266 | 725 | 15 | 1928 | 637 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000366574 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + | 0.000564066 | 0.99943596 |
ENST00000360064 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + | 0.001317921 | 0.9986821 |
ENST00000542537 | ENST00000366577 | RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044055 | + | 0.000549984 | 0.99945 |
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Fusion Genomic Features for RYR2-MTR |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044054 | + | 0.000102548 | 0.9998975 |
RYR2 | chr1 | 237551483 | + | MTR | chr1 | 237044054 | + | 0.000102548 | 0.9998975 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RYR2-MTR |
Go to FGviewer for the breakpoints of chr1:237551483-chr1:237044055 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | MTR |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880). Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880). {ECO:0000250|UniProtKB:Q8C1A3, ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17892308, ECO:0000269|PubMed:27771510, ECO:0000305|PubMed:19243433}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 110_165 | 257.6666666666667 | 4968.0 | Domain | MIR 1 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 172_217 | 257.6666666666667 | 4968.0 | Domain | MIR 2 |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 923_1265 | 864.6666666666666 | 1266.0 | Domain | AdoMet activation | |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 1227_1228 | 864.6666666666666 | 1266.0 | Region | S-adenosyl-L-methionine binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4412_4445 | 257.6666666666667 | 4968.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4414_4455 | 257.6666666666667 | 4968.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 1025_1222 | 257.6666666666667 | 4968.0 | Domain | B30.2/SPRY 2 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 1337_1562 | 257.6666666666667 | 4968.0 | Domain | B30.2/SPRY 3 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 225_280 | 257.6666666666667 | 4968.0 | Domain | MIR 3 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 286_343 | 257.6666666666667 | 4968.0 | Domain | MIR 4 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 351_408 | 257.6666666666667 | 4968.0 | Domain | MIR 5 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 599_809 | 257.6666666666667 | 4968.0 | Domain | B30.2/SPRY 1 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4820_4829 | 257.6666666666667 | 4968.0 | Intramembrane | Pore-forming |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 853_2925 | 257.6666666666667 | 4968.0 | Region | Note=4 X approximate repeats |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 2692_2810 | 257.6666666666667 | 4968.0 | Repeat | Note=3 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 2812_2925 | 257.6666666666667 | 4968.0 | Repeat | Note=4 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 853_966 | 257.6666666666667 | 4968.0 | Repeat | Note=1 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 967_1080 | 257.6666666666667 | 4968.0 | Repeat | Note=2 |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 1_4281 | 257.6666666666667 | 4968.0 | Topological domain | Cytoplasmic |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4871_4967 | 257.6666666666667 | 4968.0 | Topological domain | Cytoplasmic |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4282_4302 | 257.6666666666667 | 4968.0 | Transmembrane | Helical |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4504_4524 | 257.6666666666667 | 4968.0 | Transmembrane | Helical |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4580_4600 | 257.6666666666667 | 4968.0 | Transmembrane | Helical |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4730_4750 | 257.6666666666667 | 4968.0 | Transmembrane | Helical |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4769_4789 | 257.6666666666667 | 4968.0 | Transmembrane | Helical |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 4850_4870 | 257.6666666666667 | 4968.0 | Transmembrane | Helical |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 19_338 | 864.6666666666666 | 1266.0 | Domain | Hcy-binding | |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 371_632 | 864.6666666666666 | 1266.0 | Domain | Pterin-binding | |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 662_759 | 864.6666666666666 | 1266.0 | Domain | B12-binding N-terminal | |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 772_907 | 864.6666666666666 | 1266.0 | Domain | B12-binding | |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 382_384 | 864.6666666666666 | 1266.0 | Region | Substrate binding | |
Tgene | MTR | chr1:237551483 | chr1:237044055 | ENST00000366577 | 23 | 33 | 782_786 | 864.6666666666666 | 1266.0 | Region | Methylcob(III)alamin binding |
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Fusion Gene Sequence for RYR2-MTR |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000366574_ENST00000366577_ERR315413_RYR2_chr1_237551483_+_MTR_chr1_237044055_length(transcript)=8631nt_BP=1090nt CCGAGCGGACCGCCGGCTGCAGGCAGCGAGCGCGGCTGGGCTGCGGGGCTGCTTCCCCGCGTCCTCCGGGCCCGGGCCGCCCTCCTCCCG CACAGTGCGGAGCAGGGAGGCCCCGCGCCTCGACCACCCGCGCCCGAGCGTCCGCGCCTCCTCCTCCGCTCTGCAGGCGGGGACCGCCCG GCGCTCGGCACCCGGCAGCGCGGCCCCCTCCAGCCCCCGGCTCCCGGCAGCAGAAGCAGAAGGCAGCGCCAGGGGCCGCCGCCGCCGCCG AGCTCCGCGGGGCTCGGGAGCCGGCCCCGGCGAGGAGGCGCGGAACCATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGC GAACTGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACA GACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTG TCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTG CTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCA CCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTG CCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGT CTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCC AAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAG AGCAGCGGAGAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCTGTAATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGG TGTGTTCCCAGCTGTTAGATGAAAATCTAAAGGATGAATACTTTGAGGAAATCATGGAAGAATATGAAGATATTAGACAGGACCATTATG AGTCTCTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGTTTCCAAATGGATTGGCTGTCTGAACCTCACCCAGTGA AGCCCACGTTTATTGGGACCCAGGTCTTTGAAGACTATGACCTGCAGAAGCTGGTGGACTACATTGACTGGAAGCCTTTCTTTGATGTCT GGCAGCTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGACAAAACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATG ATGCCCACAATATGCTGAACACACTGATTAGTCAAAAGAAACTCCGGGCCCGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGTATCCAAG ACGACATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATAGCCACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGG ACTCTGCCAGCACGGAGCCATACTACTGCCTCTCAGACTTCATCGCTCCCTTGCATTCTGGCATCCGTGACTACCTGGGCCTGTTTGCCG TTGCCTGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGACGACTACAGCAGCATCATGGTCAAGGCGCTGGGGGACC GGCTGGCAGAGGCCTTTGCAGAAGAGCTCCATGAAAGAGTTCGCCGAGAACTGTGGGCCTACTGTGGCAGTGAGCAGCTGGACGTCGCAG ACCTGCGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGCCAGCCCGACCACACCGAGAAGCTCACCATGTGGAGAC TCGCAGACATCGAGCAGTCTACAGGCATTAGGTTAACAGAATCATTAGCAATGGCACCTGCTTCAGCAGTCTCAGGCCTCTACTTCTCCA ATTTGAAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAGGATTATGCATTGAGGAAGAACATATCTGTGGCTGAGG TTGAGAAATGGCTTGGACCCATTTTGGGATATGATACAGACTAACTTTTTTTTTTTTTTTGCCTTTTTTATTCTTGATGATCCTCAAGGA AATACAACCTAGGGTGCCTTAAAAATAACAACAACAAAAAACCTGTGTGCATCTGGCTGACACTTACCTGCTTCTGGTTTTCGAAGACTA TTTAGTGGAACCTTGTAGAGGAGCAGGGTCTTCCTGCAGTGCCTGGAAAACAGGCGCTGTTTTTTTGGGACCTTGCGTGAAGAGCAGTGA GCAGGGTTCCTGTGGTTTCCCTGGTCCCTCTGAGATGGGGACAGACTGAAGACAGAGGTCGTTTGATTTCAAAGCAAGTCAACCTGCTTT TTTCTGTTTTTACAGTGGAATCTAGGAGGCCACTTAGTCGTCTTTTTTTCCTCTTAGAAGAAAAGCCTGAAACTGAGTTGAATAGAGAAG TGTGACCCTGTGACAAAATGATACTGTGAGAAATGGGGCATTTTAATCTAAGTGGTTATAACAGTGGATTCTGACGGGGAAGGTGTAGCT CTGTTCTCTTCGGAAGACCTCGTTTTCTAAAGGCTGGACTAAATGGCTGCAGAACTCCCTTTGGCAAAAGGCATGCGCTCACTGCTTGCT TGTCAGAAACACTGAAGCCATTTGCCCCAGTGTGGTCAAGCAGCCATGCTTTCTGGGCATTTTCGTCCTCCCATAATTTCATATTTCCGT ACCCCTGAGGAAACAAAAAGGAAATGAGGAGAGAAAGTTACTGTTAAGGGTGGTTAACATTTTTTTTGTTTTGTTTTGTTTTGGTTTTTT TTTTTTTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGGGGCGCAATCTCGGCTCATAGCAAGCTCCGCCTCCTGGGTTCAT GCCATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTGTTTTTACAAAATACA AAAAAGTAGAGACAGGATTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCCGACCTCGTGATCTGCCCACCTCAGCCTCCCAAAATGCT GGGATTACAGGCGTGAGCCACCGAGCCTGGCCGGTTAACATCTTTTAATTGTTTCCAGGATTGAGCAGGTTCTCAGCTGGGCTCTGATAT CCCGTGCGGAGTTGGACAAGTGGGCAGCATAAAGTCACTCATTTCTTACCATTTTATTCCCCTCAATTCTCAATATATTCAGTAATGAAG AATGGTGCCACCACTCAAGCAACAAGCCTCAAACTCAACCATGTCATCTTTTTCTTGGATGATTGCAGTTATTTCAAAAATTTGCATGCA AAATATACACTCATCCTACTTCAAGATGGTGGTGGCAATAGTCAGGAGAAGGTAACATTGGAGTCCTGGTTTGATTCGAAGGATGAAGAC GAAGAAGCAAGGGAGGAACAAATGAAGAACCATCTTTGTTCATGAATAGGAATATTCAAGATTATAAAGGTATCAGGTCTCCTAAAATTG ATCTATGGATTTAATACCATTTTCAATGGAAATTCCAACAGATTTTATTGAATGAAACAAGCAGGTGTTTATATGGAGTAGCAAAGGACT TAAAATTACCAAATGCTTCTAAATATGAAGGAGAGGTTGGGGACACGCACCCTATGTGATACCAAGTTTTATTGTCAAGACAGTGTCATG GTGCAGAGGTAGGCATTCTGAGCAGGGGAACAAAATAAGGGCCTAGAAACTCACCCGTGCATATGTTGACCTTTGCAAAATGACCTGGTG ACATGGCAAGTCAGTGGGGACAGGAAGGACCACTCCCTAAGTAATCCCAGAACAATGGCTATTCATGTGGGAAAAAAAGAAATTTTACTT TCTCTCACCTTACCTGGTGATAAGTTCCAAATATGTTAAGGGCTTTAATACAAAAAGCAAAAATTGTCAGTGTTTGGATGAAAAAAGCCT TAGGGCAGGAAAGAATCTCTTGAGACATAAAGTAGTAATCATAAAGGACAAGATGGTTAAGTCAATTCTGTTAAAACTCAAGGCTTATAT TAAGCAAACACTTGAAGTGAGAAGATGATCCACAACTTGAGAAGACATTTATAATACAAATAACTGATGAAGGATTCATAATCACAAATA TAGAGAATTCCTATTTAAAAAAATAGAAAAATAGTGAAGACTACACAAGAGGAAATAGGGCTTTTAAATAAATAGATGTTCTGTAGCATT GGTCAGGGAAATATGAATTAGGACCACAATGAGATTCCATTTTATATCCATAAGATTTGCAAAGGTTGGGTCTGACAGTACCAGTTGTTA GATCTGTAGGGACTTGTACAACATTGTGGATGTGTAAACAGGCACCACTGCTTTAAAAAACAATTATCCCTTACAGACTTGAACATTTGC AGACGTTATGATCTTGCTTCCAACTCCCACCTGTATGTCCAGCAAACTCTTGCATGTGGCCACTAGGAGGAATGTGTAAGAATGTTCATA GTTACATATTTATAATAGTTAATAACTGGAAAAAGTGAAATGTATGTCTGTCTACAGGAAAATAGGTGAATAATTAGATATATATATTCA TTCTACGGGATATTATTCAGTAGTGGAAATGAGTGAACTACAGCTATACCTCACAATAAGAATGAATCTCAGAAAATATTAAGGAAAAAA GCAAGTTTGAAGAGACCACATGGGGCGTACTATTTTTATTGAGCCCAAAAACAAGCAAAACCAAAGAATATGTAGTCTAAGCATACGTAT ACAATAAAACTATGCTATTAAAAAAAAAGAAGGTAACTGATAAACCAAAATTGAGCATAGTAATTACCCACAGAAGGAGGAAGTGGAAGG GACAGGAGCACATAGGTAGATGCCAAGTTATGCAGCTGTTCTGGTTCCTCCTGGTAGGCTTACAAGTGTTTACTATATGCTATTAATACA TTATACTTTATAACTAATAGATAACAGTTTTTTACATATTAAATATGTTCTACTTAAATATATTATAAAAAATAAAGGCAAAGTGGAATG ATAACCTAAAATCTGGTATGGTGATTTTGTAGGTAATGTTTGTATATGTCAAATACAGTTTTTAAGGAAAGGAAGAACATCTTAGGGTAA ACAGCAGCTAGAAAGGTGAGGGGCAGGAGAGTGGTGCATCCTTGCTGCTGCCAGCAGTGCCCAGATACCAGGCTTTGGGGAATGAGTGGA TGGCTGGACCATTTGCTAAGACAGAGGCCAGGGGATGGGAGAAATGATGAGTTTTGGAAAGATTCGATGTGACTAGACTGAATATAGGCA GTTGGATACTAGACTTTGGAATTTAAAAAGAATGTCTGGAGTTAGAATTGAGAGACTTGAACGTGGAGATGGAGGTCAGGCTGCAGTGCG ATGGGATCATCTATGGAGCATATGAGGAGAAGAGAATCTGGAGGAGGAGGAGGGGGAGCCAGCAGGGGAGCAGCTGTGGGTTGGAGGAAG CCAGGAGGGAGAGTGCAATGCCGAGAAAGCAATGAAGAGCGTTTCGAAGCATGCCAGCAGAACCCAATGCTGCAAAGAGGCCTGGGAATG GGATTGCTGAGGGCCCTTCTCACAGTGAGCCCCTCAAGAGCAGCGTCAGGGGATTGTGGGGACTGTTGGCACACAGCTGGCTTTGCTAGG TTGAAGACAATGGGAGGTGTGGAAGACTTGTTGACTCATTTAAAGAAGATTGGAGGGAAAGGTAGGATTGAGAGTGTTTCAGACAGAAAA AGGATTATATGCTGAGGGTAAAGCACAAGTACAGAGGGTTGCAGATAGTGCAGAAGTCTTTAAAAACAATTATTTTAACCCAACTTCCAG GGAGACTGAATTTCTTCTGCCAGTCAGTAACACCATCAACCTGGGAGTTGCCCCTGACCCCTCCAGTCTTAGCTCCTGCTCCTGTAACAA AATACCACAAACTGGTTAGCTTATAGAGAACAGATGTTTATTTCTTACAGTTCAGGAGTCTGGAAGTCCAAGATCATGGTGCCATCATGG CCGAGTTCTGGTGAGGGCCCTCTTCTGGGATGCAGCGGCCAGCTTCTCATGTTCTCACAGTGGGTGGAGGGTAAGCTTGCTCTCTGGCCT CCTCTTAAAAAGGCACTAATCCCATTCATGAGGGCTCCACCTTCATGACCTAATTACCTCCCAAAGATGCCATCTCCAAACACCATCATT CTGGGGATTCCATTTCAACATGATTTGGGGGATACATCAGACCATAACACTTTTCTTTTTCTCAACCTTCACATCCAGTTGGTTCTCAAG CCCTGGCGATTTTACGCGCTAGATAGGTCTTAAGTTCATCTCTACGCCTGCCCTGGTTAAGGTTCTCATCATTTCTCCTCTGGATTCATC TGCAACACAGGCTGCCGGGTTGGTTCCCACCTCCTAGAGCTGGAAGAGTGGGCTCTCTGATTCTTTACACCCCCGCCTCAATCCTCCTGC TGCCTGAATAACCATCTCCCCGTGACCTAGGATATATCCCAGCCCCTTAGAGGCATGCAAAGCCTTCCATGTCTGACCCTGCCTCATGTC TTGGAAGCCCTAGACTGCTGCTGTACCCTGAAGGAGGTACCTGCTCACATTGGCCCCTCTGTCTGGAATAACCCCACCCCGGTTCCACCC AAGTCAGGAAAGCTTCCCAACCCCTCCCTCCCACCACCCCAAAGCTAAGTGAAGTGACCCCTCTTCTTGCCTCTGTAACACCGCCATGCA CATTTCATACAGCCCTTGCTGAAACTTCATCTAGTTCTCTGTTAGACTTAACATTCCCTAAGGGCAGGTTTGGAACCTTACTCATCTTTA TATGGCGTCTAAAATAGTGCTTGCTTTATGATAGGTGCTCAGTAAAGGTTGTCTTGAATTGAGCAGATCCTCTAGGGACAGGAGTTGGAT GGAGAGCAGACTGTAAAGCCTCATGAGGGCAGGGGCCCTGCCTCTTCCTGAGCTCAGGATACCCAGAGCCTAGCTCAGTGCCTGCCATGA AATTGTTCACTCCATCAAGCCTTGTTAAATGAGTTCGGGGCGGGGGGAGCATGATGGTTTTCTCTCTCTCAGAAAGAAAGCGCTGTATCA AAGCCCTAGCACCCTCTCTACACCCACCTTCAGTATTTCATATTAGATGCGGCCCAAGTGATACTTTCTTTACCGTCCCGTGAAGACAGC ATATTGGCAGCCCTGCAAAAACAAAACAAAACAAAACCCTCAGTTCATGGCATACTTGCTATAAATCAGCTATGTGTATTGTCAAATTGT AGAACTGAAAGTATATTCTGATTCGGTGTGTGTATAAGGAAATATACACCAGTATATGCATTAAAACGTCAAGAAGAGCTGGGCACAGTG TCACATGCCTGTAAACCCAGCTATTCAGGAGGCTGAGGTGGGAGGATCGGTTGAGGCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGC ACAGCTGCACTCCAGCCTGTGCTGAGACCTCATCTCTTAAAAAATAAAAAATAAAAAGTCTAAGAGGATACACAGAAATTTTTAAGTGGT TACCTCCACGGAATGGGATTAGGGGATCAGAGGTGAGGGAACTCATGGTTTGGCTATTTCTCGTTCTTTCTGCACTGTTTCAAATTTTTA CAAGTGTATGTTATTGTACTTTTAAAAAGATTAGCTTGGCAACAAGTCTAGCCTGAAATGGGTGCTATTTTGACTAGTCTGAGTGAAAAG TGAGGATTTAAATGAAGTAACCCCTAAACTCAGCCAGTCCCATGTTTTTTTAACACTTGGAATATCTAATTCCATTTACACTGCATTCTT CAAATGTAATTTTCAAAGATGCCTTTTGCCTCATCCCTTGCTTTTAAGTATTATTATAGACTTTTGGAGACTCACGAAACAAGCAATCCC TAAATTCTCGCCCAGGAAAGTATCTTGGATTAAATGGTTTTTGAGAACCTTGAGAGTGTATATTCTATGAAATGGAAGAAACAAGAACTA GACAGAGTCACAAATGCTGTTGATCACAGACAATCTCTGCCATCCATAAGGTAAATGTAATACATCTGGCGACCTGCTGAGTGTGAACTT GCAGCAGGTGAGGAAGGAACTCTGAACTCTCACAATCTTGTTTCTTCATTTCCCAGAGAGAAACTCGGCAAAGAGAAAAAGGACATTTCC CTCCAGGTTATCTGAAAGAATTTCAATGCTTACCTTTAATCATGTGACATTGTTTATCTTGGATTAAAAGAAAAGAAAATGTATTTATTT >In-frame_ENST00000366574_ENST00000366577_ERR315413_RYR2_chr1_237551483_+_MTR_chr1_237044055_length(amino acids)=752AA_start in transcript=35_stop in transcript=2293 MGCGAASPRPPGPGRPPPAQCGAGRPRASTTRARASAPPPPLCRRGPPGARHPAARPPPAPGSRQQKQKAAPGAAAAAELRGAREPAPAR RRGTMADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTV EKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVR VGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTHTAVKIA PRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFED YDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVP QAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHE RVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKI -------------------------------------------------------------- >In-frame_ENST00000360064_ENST00000366577_ERR315413_RYR2_chr1_237551483_+_MTR_chr1_237044055_length(transcript)=8308nt_BP=767nt CTGGGCCCTAGATCCTCATCTAACAAGCTCTCAAATAAAAAGATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAAC AGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCT CCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGGCAA CTAGATATCATTAAATGGTCATTTGGTCTAAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGC CATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGAC ACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATC TTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGG AGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGAC GAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCT GTAATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGGTGTGTTCCCAGCTGTTAGATGAAAATCTAAAGGATGAATACTTTGAGGAAATC ATGGAAGAATATGAAGATATTAGACAGGACCATTATGAGTCTCTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGT TTCCAAATGGATTGGCTGTCTGAACCTCACCCAGTGAAGCCCACGTTTATTGGGACCCAGGTCTTTGAAGACTATGACCTGCAGAAGCTG GTGGACTACATTGACTGGAAGCCTTTCTTTGATGTCTGGCAGCTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGAC AAAACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATGATGCCCACAATATGCTGAACACACTGATTAGTCAAAAGAAACTCCGGGCCCGG GGTGTGGTTGGGTTCTGGCCAGCACAGAGTATCCAAGACGACATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATA GCCACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGGACTCTGCCAGCACGGAGCCATACTACTGCCTCTCAGACTTCATCGCTCCCTTG CATTCTGGCATCCGTGACTACCTGGGCCTGTTTGCCGTTGCCTGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGAC GACTACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTGGCAGAGGCCTTTGCAGAAGAGCTCCATGAAAGAGTTCGCCGAGAACTG TGGGCCTACTGTGGCAGTGAGCAGCTGGACGTCGCAGACCTGCGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGC CAGCCCGACCACACCGAGAAGCTCACCATGTGGAGACTCGCAGACATCGAGCAGTCTACAGGCATTAGGTTAACAGAATCATTAGCAATG GCACCTGCTTCAGCAGTCTCAGGCCTCTACTTCTCCAATTTGAAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAG GATTATGCATTGAGGAAGAACATATCTGTGGCTGAGGTTGAGAAATGGCTTGGACCCATTTTGGGATATGATACAGACTAACTTTTTTTT TTTTTTTGCCTTTTTTATTCTTGATGATCCTCAAGGAAATACAACCTAGGGTGCCTTAAAAATAACAACAACAAAAAACCTGTGTGCATC TGGCTGACACTTACCTGCTTCTGGTTTTCGAAGACTATTTAGTGGAACCTTGTAGAGGAGCAGGGTCTTCCTGCAGTGCCTGGAAAACAG GCGCTGTTTTTTTGGGACCTTGCGTGAAGAGCAGTGAGCAGGGTTCCTGTGGTTTCCCTGGTCCCTCTGAGATGGGGACAGACTGAAGAC AGAGGTCGTTTGATTTCAAAGCAAGTCAACCTGCTTTTTTCTGTTTTTACAGTGGAATCTAGGAGGCCACTTAGTCGTCTTTTTTTCCTC TTAGAAGAAAAGCCTGAAACTGAGTTGAATAGAGAAGTGTGACCCTGTGACAAAATGATACTGTGAGAAATGGGGCATTTTAATCTAAGT GGTTATAACAGTGGATTCTGACGGGGAAGGTGTAGCTCTGTTCTCTTCGGAAGACCTCGTTTTCTAAAGGCTGGACTAAATGGCTGCAGA ACTCCCTTTGGCAAAAGGCATGCGCTCACTGCTTGCTTGTCAGAAACACTGAAGCCATTTGCCCCAGTGTGGTCAAGCAGCCATGCTTTC TGGGCATTTTCGTCCTCCCATAATTTCATATTTCCGTACCCCTGAGGAAACAAAAAGGAAATGAGGAGAGAAAGTTACTGTTAAGGGTGG TTAACATTTTTTTTGTTTTGTTTTGTTTTGGTTTTTTTTTTTTTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGGGGCGCA ATCTCGGCTCATAGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGTGCCCGCCAC CACACCCGGCTAATTTTTTGTGTTTTTACAAAATACAAAAAAGTAGAGACAGGATTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCCG ACCTCGTGATCTGCCCACCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGAGCCTGGCCGGTTAACATCTTTTAATTGTT TCCAGGATTGAGCAGGTTCTCAGCTGGGCTCTGATATCCCGTGCGGAGTTGGACAAGTGGGCAGCATAAAGTCACTCATTTCTTACCATT TTATTCCCCTCAATTCTCAATATATTCAGTAATGAAGAATGGTGCCACCACTCAAGCAACAAGCCTCAAACTCAACCATGTCATCTTTTT CTTGGATGATTGCAGTTATTTCAAAAATTTGCATGCAAAATATACACTCATCCTACTTCAAGATGGTGGTGGCAATAGTCAGGAGAAGGT AACATTGGAGTCCTGGTTTGATTCGAAGGATGAAGACGAAGAAGCAAGGGAGGAACAAATGAAGAACCATCTTTGTTCATGAATAGGAAT ATTCAAGATTATAAAGGTATCAGGTCTCCTAAAATTGATCTATGGATTTAATACCATTTTCAATGGAAATTCCAACAGATTTTATTGAAT GAAACAAGCAGGTGTTTATATGGAGTAGCAAAGGACTTAAAATTACCAAATGCTTCTAAATATGAAGGAGAGGTTGGGGACACGCACCCT ATGTGATACCAAGTTTTATTGTCAAGACAGTGTCATGGTGCAGAGGTAGGCATTCTGAGCAGGGGAACAAAATAAGGGCCTAGAAACTCA CCCGTGCATATGTTGACCTTTGCAAAATGACCTGGTGACATGGCAAGTCAGTGGGGACAGGAAGGACCACTCCCTAAGTAATCCCAGAAC AATGGCTATTCATGTGGGAAAAAAAGAAATTTTACTTTCTCTCACCTTACCTGGTGATAAGTTCCAAATATGTTAAGGGCTTTAATACAA AAAGCAAAAATTGTCAGTGTTTGGATGAAAAAAGCCTTAGGGCAGGAAAGAATCTCTTGAGACATAAAGTAGTAATCATAAAGGACAAGA TGGTTAAGTCAATTCTGTTAAAACTCAAGGCTTATATTAAGCAAACACTTGAAGTGAGAAGATGATCCACAACTTGAGAAGACATTTATA ATACAAATAACTGATGAAGGATTCATAATCACAAATATAGAGAATTCCTATTTAAAAAAATAGAAAAATAGTGAAGACTACACAAGAGGA AATAGGGCTTTTAAATAAATAGATGTTCTGTAGCATTGGTCAGGGAAATATGAATTAGGACCACAATGAGATTCCATTTTATATCCATAA GATTTGCAAAGGTTGGGTCTGACAGTACCAGTTGTTAGATCTGTAGGGACTTGTACAACATTGTGGATGTGTAAACAGGCACCACTGCTT TAAAAAACAATTATCCCTTACAGACTTGAACATTTGCAGACGTTATGATCTTGCTTCCAACTCCCACCTGTATGTCCAGCAAACTCTTGC ATGTGGCCACTAGGAGGAATGTGTAAGAATGTTCATAGTTACATATTTATAATAGTTAATAACTGGAAAAAGTGAAATGTATGTCTGTCT ACAGGAAAATAGGTGAATAATTAGATATATATATTCATTCTACGGGATATTATTCAGTAGTGGAAATGAGTGAACTACAGCTATACCTCA CAATAAGAATGAATCTCAGAAAATATTAAGGAAAAAAGCAAGTTTGAAGAGACCACATGGGGCGTACTATTTTTATTGAGCCCAAAAACA AGCAAAACCAAAGAATATGTAGTCTAAGCATACGTATACAATAAAACTATGCTATTAAAAAAAAAGAAGGTAACTGATAAACCAAAATTG AGCATAGTAATTACCCACAGAAGGAGGAAGTGGAAGGGACAGGAGCACATAGGTAGATGCCAAGTTATGCAGCTGTTCTGGTTCCTCCTG GTAGGCTTACAAGTGTTTACTATATGCTATTAATACATTATACTTTATAACTAATAGATAACAGTTTTTTACATATTAAATATGTTCTAC TTAAATATATTATAAAAAATAAAGGCAAAGTGGAATGATAACCTAAAATCTGGTATGGTGATTTTGTAGGTAATGTTTGTATATGTCAAA TACAGTTTTTAAGGAAAGGAAGAACATCTTAGGGTAAACAGCAGCTAGAAAGGTGAGGGGCAGGAGAGTGGTGCATCCTTGCTGCTGCCA GCAGTGCCCAGATACCAGGCTTTGGGGAATGAGTGGATGGCTGGACCATTTGCTAAGACAGAGGCCAGGGGATGGGAGAAATGATGAGTT TTGGAAAGATTCGATGTGACTAGACTGAATATAGGCAGTTGGATACTAGACTTTGGAATTTAAAAAGAATGTCTGGAGTTAGAATTGAGA GACTTGAACGTGGAGATGGAGGTCAGGCTGCAGTGCGATGGGATCATCTATGGAGCATATGAGGAGAAGAGAATCTGGAGGAGGAGGAGG GGGAGCCAGCAGGGGAGCAGCTGTGGGTTGGAGGAAGCCAGGAGGGAGAGTGCAATGCCGAGAAAGCAATGAAGAGCGTTTCGAAGCATG CCAGCAGAACCCAATGCTGCAAAGAGGCCTGGGAATGGGATTGCTGAGGGCCCTTCTCACAGTGAGCCCCTCAAGAGCAGCGTCAGGGGA TTGTGGGGACTGTTGGCACACAGCTGGCTTTGCTAGGTTGAAGACAATGGGAGGTGTGGAAGACTTGTTGACTCATTTAAAGAAGATTGG AGGGAAAGGTAGGATTGAGAGTGTTTCAGACAGAAAAAGGATTATATGCTGAGGGTAAAGCACAAGTACAGAGGGTTGCAGATAGTGCAG AAGTCTTTAAAAACAATTATTTTAACCCAACTTCCAGGGAGACTGAATTTCTTCTGCCAGTCAGTAACACCATCAACCTGGGAGTTGCCC CTGACCCCTCCAGTCTTAGCTCCTGCTCCTGTAACAAAATACCACAAACTGGTTAGCTTATAGAGAACAGATGTTTATTTCTTACAGTTC AGGAGTCTGGAAGTCCAAGATCATGGTGCCATCATGGCCGAGTTCTGGTGAGGGCCCTCTTCTGGGATGCAGCGGCCAGCTTCTCATGTT CTCACAGTGGGTGGAGGGTAAGCTTGCTCTCTGGCCTCCTCTTAAAAAGGCACTAATCCCATTCATGAGGGCTCCACCTTCATGACCTAA TTACCTCCCAAAGATGCCATCTCCAAACACCATCATTCTGGGGATTCCATTTCAACATGATTTGGGGGATACATCAGACCATAACACTTT TCTTTTTCTCAACCTTCACATCCAGTTGGTTCTCAAGCCCTGGCGATTTTACGCGCTAGATAGGTCTTAAGTTCATCTCTACGCCTGCCC TGGTTAAGGTTCTCATCATTTCTCCTCTGGATTCATCTGCAACACAGGCTGCCGGGTTGGTTCCCACCTCCTAGAGCTGGAAGAGTGGGC TCTCTGATTCTTTACACCCCCGCCTCAATCCTCCTGCTGCCTGAATAACCATCTCCCCGTGACCTAGGATATATCCCAGCCCCTTAGAGG CATGCAAAGCCTTCCATGTCTGACCCTGCCTCATGTCTTGGAAGCCCTAGACTGCTGCTGTACCCTGAAGGAGGTACCTGCTCACATTGG CCCCTCTGTCTGGAATAACCCCACCCCGGTTCCACCCAAGTCAGGAAAGCTTCCCAACCCCTCCCTCCCACCACCCCAAAGCTAAGTGAA GTGACCCCTCTTCTTGCCTCTGTAACACCGCCATGCACATTTCATACAGCCCTTGCTGAAACTTCATCTAGTTCTCTGTTAGACTTAACA TTCCCTAAGGGCAGGTTTGGAACCTTACTCATCTTTATATGGCGTCTAAAATAGTGCTTGCTTTATGATAGGTGCTCAGTAAAGGTTGTC TTGAATTGAGCAGATCCTCTAGGGACAGGAGTTGGATGGAGAGCAGACTGTAAAGCCTCATGAGGGCAGGGGCCCTGCCTCTTCCTGAGC TCAGGATACCCAGAGCCTAGCTCAGTGCCTGCCATGAAATTGTTCACTCCATCAAGCCTTGTTAAATGAGTTCGGGGCGGGGGGAGCATG ATGGTTTTCTCTCTCTCAGAAAGAAAGCGCTGTATCAAAGCCCTAGCACCCTCTCTACACCCACCTTCAGTATTTCATATTAGATGCGGC CCAAGTGATACTTTCTTTACCGTCCCGTGAAGACAGCATATTGGCAGCCCTGCAAAAACAAAACAAAACAAAACCCTCAGTTCATGGCAT ACTTGCTATAAATCAGCTATGTGTATTGTCAAATTGTAGAACTGAAAGTATATTCTGATTCGGTGTGTGTATAAGGAAATATACACCAGT ATATGCATTAAAACGTCAAGAAGAGCTGGGCACAGTGTCACATGCCTGTAAACCCAGCTATTCAGGAGGCTGAGGTGGGAGGATCGGTTG AGGCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACAGCTGCACTCCAGCCTGTGCTGAGACCTCATCTCTTAAAAAATAAAAAATA AAAAGTCTAAGAGGATACACAGAAATTTTTAAGTGGTTACCTCCACGGAATGGGATTAGGGGATCAGAGGTGAGGGAACTCATGGTTTGG CTATTTCTCGTTCTTTCTGCACTGTTTCAAATTTTTACAAGTGTATGTTATTGTACTTTTAAAAAGATTAGCTTGGCAACAAGTCTAGCC TGAAATGGGTGCTATTTTGACTAGTCTGAGTGAAAAGTGAGGATTTAAATGAAGTAACCCCTAAACTCAGCCAGTCCCATGTTTTTTTAA CACTTGGAATATCTAATTCCATTTACACTGCATTCTTCAAATGTAATTTTCAAAGATGCCTTTTGCCTCATCCCTTGCTTTTAAGTATTA TTATAGACTTTTGGAGACTCACGAAACAAGCAATCCCTAAATTCTCGCCCAGGAAAGTATCTTGGATTAAATGGTTTTTGAGAACCTTGA GAGTGTATATTCTATGAAATGGAAGAAACAAGAACTAGACAGAGTCACAAATGCTGTTGATCACAGACAATCTCTGCCATCCATAAGGTA AATGTAATACATCTGGCGACCTGCTGAGTGTGAACTTGCAGCAGGTGAGGAAGGAACTCTGAACTCTCACAATCTTGTTTCTTCATTTCC CAGAGAGAAACTCGGCAAAGAGAAAAAGGACATTTCCCTCCAGGTTATCTGAAAGAATTTCAATGCTTACCTTTAATCATGTGACATTGT TTATCTTGGATTAAAAGAAAAGAAAATGTATTTATTTTGTGCATATTTTCAATAAAATATATAAAATCGAGTTGGTATATAGTGCCAAAT >In-frame_ENST00000360064_ENST00000366577_ERR315413_RYR2_chr1_237551483_+_MTR_chr1_237044055_length(amino acids)=656AA_start in transcript=0_stop in transcript=1970 LGPRSSSNKLSNKKMMKWFCSAPQPSTKNNRSYAWQQKDLATDFVSWSPLPIPRMCPQTSPSAPLCWSSPSLSGRCRRCWLTPWRNQKGQ LDIIKWSFGLKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLI LVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTHTAVKIAPRYSAP VIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKL VDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPI ATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRREL WAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVE -------------------------------------------------------------- >In-frame_ENST00000542537_ENST00000366577_ERR315413_RYR2_chr1_237551483_+_MTR_chr1_237044055_length(transcript)=8266nt_BP=725nt GATGATGAAGTGGTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAAGGATTTGGCAACAGACTT TGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCAGACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGG GCGCTGCAGGAGATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTCATGATGAAGACTGCTCAA GGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTGCTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCC CGGTCTTCAACTGATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGGACCATACACCCTGCCTCT AAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGACCTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTAT GGCAACGGCAGCTTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGAAGTGAGGCAGCCCAAGGG TATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACACATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAG CGGAGAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCTGTAATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGGTGTGT TCCCAGCTGTTAGATGAAAATCTAAAGGATGAATACTTTGAGGAAATCATGGAAGAATATGAAGATATTAGACAGGACCATTATGAGTCT CTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGTTTCCAAATGGATTGGCTGTCTGAACCTCACCCAGTGAAGCCC ACGTTTATTGGGACCCAGGTCTTTGAAGACTATGACCTGCAGAAGCTGGTGGACTACATTGACTGGAAGCCTTTCTTTGATGTCTGGCAG CTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGACAAAACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATGATGCC CACAATATGCTGAACACACTGATTAGTCAAAAGAAACTCCGGGCCCGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGTATCCAAGACGAC ATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATAGCCACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGGACTCT GCCAGCACGGAGCCATACTACTGCCTCTCAGACTTCATCGCTCCCTTGCATTCTGGCATCCGTGACTACCTGGGCCTGTTTGCCGTTGCC TGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGACGACTACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTG GCAGAGGCCTTTGCAGAAGAGCTCCATGAAAGAGTTCGCCGAGAACTGTGGGCCTACTGTGGCAGTGAGCAGCTGGACGTCGCAGACCTG CGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGCCAGCCCGACCACACCGAGAAGCTCACCATGTGGAGACTCGCA GACATCGAGCAGTCTACAGGCATTAGGTTAACAGAATCATTAGCAATGGCACCTGCTTCAGCAGTCTCAGGCCTCTACTTCTCCAATTTG AAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAGGATTATGCATTGAGGAAGAACATATCTGTGGCTGAGGTTGAG AAATGGCTTGGACCCATTTTGGGATATGATACAGACTAACTTTTTTTTTTTTTTTGCCTTTTTTATTCTTGATGATCCTCAAGGAAATAC AACCTAGGGTGCCTTAAAAATAACAACAACAAAAAACCTGTGTGCATCTGGCTGACACTTACCTGCTTCTGGTTTTCGAAGACTATTTAG TGGAACCTTGTAGAGGAGCAGGGTCTTCCTGCAGTGCCTGGAAAACAGGCGCTGTTTTTTTGGGACCTTGCGTGAAGAGCAGTGAGCAGG GTTCCTGTGGTTTCCCTGGTCCCTCTGAGATGGGGACAGACTGAAGACAGAGGTCGTTTGATTTCAAAGCAAGTCAACCTGCTTTTTTCT GTTTTTACAGTGGAATCTAGGAGGCCACTTAGTCGTCTTTTTTTCCTCTTAGAAGAAAAGCCTGAAACTGAGTTGAATAGAGAAGTGTGA CCCTGTGACAAAATGATACTGTGAGAAATGGGGCATTTTAATCTAAGTGGTTATAACAGTGGATTCTGACGGGGAAGGTGTAGCTCTGTT CTCTTCGGAAGACCTCGTTTTCTAAAGGCTGGACTAAATGGCTGCAGAACTCCCTTTGGCAAAAGGCATGCGCTCACTGCTTGCTTGTCA GAAACACTGAAGCCATTTGCCCCAGTGTGGTCAAGCAGCCATGCTTTCTGGGCATTTTCGTCCTCCCATAATTTCATATTTCCGTACCCC TGAGGAAACAAAAAGGAAATGAGGAGAGAAAGTTACTGTTAAGGGTGGTTAACATTTTTTTTGTTTTGTTTTGTTTTGGTTTTTTTTTTT TTGAGACAGAGTCTGGCTCTGTCGCCCAGGCTGGAGTGCAGGGGCGCAATCTCGGCTCATAGCAAGCTCCGCCTCCTGGGTTCATGCCAT TCTCCTGCCTCAGCCTCCAGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTGTTTTTACAAAATACAAAAAA GTAGAGACAGGATTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCCGACCTCGTGATCTGCCCACCTCAGCCTCCCAAAATGCTGGGAT TACAGGCGTGAGCCACCGAGCCTGGCCGGTTAACATCTTTTAATTGTTTCCAGGATTGAGCAGGTTCTCAGCTGGGCTCTGATATCCCGT GCGGAGTTGGACAAGTGGGCAGCATAAAGTCACTCATTTCTTACCATTTTATTCCCCTCAATTCTCAATATATTCAGTAATGAAGAATGG TGCCACCACTCAAGCAACAAGCCTCAAACTCAACCATGTCATCTTTTTCTTGGATGATTGCAGTTATTTCAAAAATTTGCATGCAAAATA TACACTCATCCTACTTCAAGATGGTGGTGGCAATAGTCAGGAGAAGGTAACATTGGAGTCCTGGTTTGATTCGAAGGATGAAGACGAAGA AGCAAGGGAGGAACAAATGAAGAACCATCTTTGTTCATGAATAGGAATATTCAAGATTATAAAGGTATCAGGTCTCCTAAAATTGATCTA TGGATTTAATACCATTTTCAATGGAAATTCCAACAGATTTTATTGAATGAAACAAGCAGGTGTTTATATGGAGTAGCAAAGGACTTAAAA TTACCAAATGCTTCTAAATATGAAGGAGAGGTTGGGGACACGCACCCTATGTGATACCAAGTTTTATTGTCAAGACAGTGTCATGGTGCA GAGGTAGGCATTCTGAGCAGGGGAACAAAATAAGGGCCTAGAAACTCACCCGTGCATATGTTGACCTTTGCAAAATGACCTGGTGACATG GCAAGTCAGTGGGGACAGGAAGGACCACTCCCTAAGTAATCCCAGAACAATGGCTATTCATGTGGGAAAAAAAGAAATTTTACTTTCTCT CACCTTACCTGGTGATAAGTTCCAAATATGTTAAGGGCTTTAATACAAAAAGCAAAAATTGTCAGTGTTTGGATGAAAAAAGCCTTAGGG CAGGAAAGAATCTCTTGAGACATAAAGTAGTAATCATAAAGGACAAGATGGTTAAGTCAATTCTGTTAAAACTCAAGGCTTATATTAAGC AAACACTTGAAGTGAGAAGATGATCCACAACTTGAGAAGACATTTATAATACAAATAACTGATGAAGGATTCATAATCACAAATATAGAG AATTCCTATTTAAAAAAATAGAAAAATAGTGAAGACTACACAAGAGGAAATAGGGCTTTTAAATAAATAGATGTTCTGTAGCATTGGTCA GGGAAATATGAATTAGGACCACAATGAGATTCCATTTTATATCCATAAGATTTGCAAAGGTTGGGTCTGACAGTACCAGTTGTTAGATCT GTAGGGACTTGTACAACATTGTGGATGTGTAAACAGGCACCACTGCTTTAAAAAACAATTATCCCTTACAGACTTGAACATTTGCAGACG TTATGATCTTGCTTCCAACTCCCACCTGTATGTCCAGCAAACTCTTGCATGTGGCCACTAGGAGGAATGTGTAAGAATGTTCATAGTTAC ATATTTATAATAGTTAATAACTGGAAAAAGTGAAATGTATGTCTGTCTACAGGAAAATAGGTGAATAATTAGATATATATATTCATTCTA CGGGATATTATTCAGTAGTGGAAATGAGTGAACTACAGCTATACCTCACAATAAGAATGAATCTCAGAAAATATTAAGGAAAAAAGCAAG TTTGAAGAGACCACATGGGGCGTACTATTTTTATTGAGCCCAAAAACAAGCAAAACCAAAGAATATGTAGTCTAAGCATACGTATACAAT AAAACTATGCTATTAAAAAAAAAGAAGGTAACTGATAAACCAAAATTGAGCATAGTAATTACCCACAGAAGGAGGAAGTGGAAGGGACAG GAGCACATAGGTAGATGCCAAGTTATGCAGCTGTTCTGGTTCCTCCTGGTAGGCTTACAAGTGTTTACTATATGCTATTAATACATTATA CTTTATAACTAATAGATAACAGTTTTTTACATATTAAATATGTTCTACTTAAATATATTATAAAAAATAAAGGCAAAGTGGAATGATAAC CTAAAATCTGGTATGGTGATTTTGTAGGTAATGTTTGTATATGTCAAATACAGTTTTTAAGGAAAGGAAGAACATCTTAGGGTAAACAGC AGCTAGAAAGGTGAGGGGCAGGAGAGTGGTGCATCCTTGCTGCTGCCAGCAGTGCCCAGATACCAGGCTTTGGGGAATGAGTGGATGGCT GGACCATTTGCTAAGACAGAGGCCAGGGGATGGGAGAAATGATGAGTTTTGGAAAGATTCGATGTGACTAGACTGAATATAGGCAGTTGG ATACTAGACTTTGGAATTTAAAAAGAATGTCTGGAGTTAGAATTGAGAGACTTGAACGTGGAGATGGAGGTCAGGCTGCAGTGCGATGGG ATCATCTATGGAGCATATGAGGAGAAGAGAATCTGGAGGAGGAGGAGGGGGAGCCAGCAGGGGAGCAGCTGTGGGTTGGAGGAAGCCAGG AGGGAGAGTGCAATGCCGAGAAAGCAATGAAGAGCGTTTCGAAGCATGCCAGCAGAACCCAATGCTGCAAAGAGGCCTGGGAATGGGATT GCTGAGGGCCCTTCTCACAGTGAGCCCCTCAAGAGCAGCGTCAGGGGATTGTGGGGACTGTTGGCACACAGCTGGCTTTGCTAGGTTGAA GACAATGGGAGGTGTGGAAGACTTGTTGACTCATTTAAAGAAGATTGGAGGGAAAGGTAGGATTGAGAGTGTTTCAGACAGAAAAAGGAT TATATGCTGAGGGTAAAGCACAAGTACAGAGGGTTGCAGATAGTGCAGAAGTCTTTAAAAACAATTATTTTAACCCAACTTCCAGGGAGA CTGAATTTCTTCTGCCAGTCAGTAACACCATCAACCTGGGAGTTGCCCCTGACCCCTCCAGTCTTAGCTCCTGCTCCTGTAACAAAATAC CACAAACTGGTTAGCTTATAGAGAACAGATGTTTATTTCTTACAGTTCAGGAGTCTGGAAGTCCAAGATCATGGTGCCATCATGGCCGAG TTCTGGTGAGGGCCCTCTTCTGGGATGCAGCGGCCAGCTTCTCATGTTCTCACAGTGGGTGGAGGGTAAGCTTGCTCTCTGGCCTCCTCT TAAAAAGGCACTAATCCCATTCATGAGGGCTCCACCTTCATGACCTAATTACCTCCCAAAGATGCCATCTCCAAACACCATCATTCTGGG GATTCCATTTCAACATGATTTGGGGGATACATCAGACCATAACACTTTTCTTTTTCTCAACCTTCACATCCAGTTGGTTCTCAAGCCCTG GCGATTTTACGCGCTAGATAGGTCTTAAGTTCATCTCTACGCCTGCCCTGGTTAAGGTTCTCATCATTTCTCCTCTGGATTCATCTGCAA CACAGGCTGCCGGGTTGGTTCCCACCTCCTAGAGCTGGAAGAGTGGGCTCTCTGATTCTTTACACCCCCGCCTCAATCCTCCTGCTGCCT GAATAACCATCTCCCCGTGACCTAGGATATATCCCAGCCCCTTAGAGGCATGCAAAGCCTTCCATGTCTGACCCTGCCTCATGTCTTGGA AGCCCTAGACTGCTGCTGTACCCTGAAGGAGGTACCTGCTCACATTGGCCCCTCTGTCTGGAATAACCCCACCCCGGTTCCACCCAAGTC AGGAAAGCTTCCCAACCCCTCCCTCCCACCACCCCAAAGCTAAGTGAAGTGACCCCTCTTCTTGCCTCTGTAACACCGCCATGCACATTT CATACAGCCCTTGCTGAAACTTCATCTAGTTCTCTGTTAGACTTAACATTCCCTAAGGGCAGGTTTGGAACCTTACTCATCTTTATATGG CGTCTAAAATAGTGCTTGCTTTATGATAGGTGCTCAGTAAAGGTTGTCTTGAATTGAGCAGATCCTCTAGGGACAGGAGTTGGATGGAGA GCAGACTGTAAAGCCTCATGAGGGCAGGGGCCCTGCCTCTTCCTGAGCTCAGGATACCCAGAGCCTAGCTCAGTGCCTGCCATGAAATTG TTCACTCCATCAAGCCTTGTTAAATGAGTTCGGGGCGGGGGGAGCATGATGGTTTTCTCTCTCTCAGAAAGAAAGCGCTGTATCAAAGCC CTAGCACCCTCTCTACACCCACCTTCAGTATTTCATATTAGATGCGGCCCAAGTGATACTTTCTTTACCGTCCCGTGAAGACAGCATATT GGCAGCCCTGCAAAAACAAAACAAAACAAAACCCTCAGTTCATGGCATACTTGCTATAAATCAGCTATGTGTATTGTCAAATTGTAGAAC TGAAAGTATATTCTGATTCGGTGTGTGTATAAGGAAATATACACCAGTATATGCATTAAAACGTCAAGAAGAGCTGGGCACAGTGTCACA TGCCTGTAAACCCAGCTATTCAGGAGGCTGAGGTGGGAGGATCGGTTGAGGCCAGGAGTTTGAGGCTGCAGTGAGCTATGATTGCACAGC TGCACTCCAGCCTGTGCTGAGACCTCATCTCTTAAAAAATAAAAAATAAAAAGTCTAAGAGGATACACAGAAATTTTTAAGTGGTTACCT CCACGGAATGGGATTAGGGGATCAGAGGTGAGGGAACTCATGGTTTGGCTATTTCTCGTTCTTTCTGCACTGTTTCAAATTTTTACAAGT GTATGTTATTGTACTTTTAAAAAGATTAGCTTGGCAACAAGTCTAGCCTGAAATGGGTGCTATTTTGACTAGTCTGAGTGAAAAGTGAGG ATTTAAATGAAGTAACCCCTAAACTCAGCCAGTCCCATGTTTTTTTAACACTTGGAATATCTAATTCCATTTACACTGCATTCTTCAAAT GTAATTTTCAAAGATGCCTTTTGCCTCATCCCTTGCTTTTAAGTATTATTATAGACTTTTGGAGACTCACGAAACAAGCAATCCCTAAAT TCTCGCCCAGGAAAGTATCTTGGATTAAATGGTTTTTGAGAACCTTGAGAGTGTATATTCTATGAAATGGAAGAAACAAGAACTAGACAG AGTCACAAATGCTGTTGATCACAGACAATCTCTGCCATCCATAAGGTAAATGTAATACATCTGGCGACCTGCTGAGTGTGAACTTGCAGC AGGTGAGGAAGGAACTCTGAACTCTCACAATCTTGTTTCTTCATTTCCCAGAGAGAAACTCGGCAAAGAGAAAAAGGACATTTCCCTCCA GGTTATCTGAAAGAATTTCAATGCTTACCTTTAATCATGTGACATTGTTTATCTTGGATTAAAAGAAAAGAAAATGTATTTATTTTGTGC >In-frame_ENST00000542537_ENST00000366577_ERR315413_RYR2_chr1_237551483_+_MTR_chr1_237044055_length(amino acids)=637AA_start in transcript=15_stop in transcript=1928 MQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHR TLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSL HVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLD ENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKY PNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEP YYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRY KGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RYR2-MTR |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | RYR2 | chr1:237551483 | chr1:237044055 | ENST00000366574 | + | 10 | 105 | 3581_3610 | 257.6666666666667 | 4968.0 | CALM |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RYR2-MTR |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MTR | Q9UBK8 | DB00115 | Cyanocobalamin | Cofactor | Small molecule | Approved|Nutraceutical |
Tgene | MTR | Q9UBK8 | DB00134 | Methionine | Product of | Small molecule | Approved|Nutraceutical |
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Related Diseases for RYR2-MTR |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RYR2 | C1631597 | VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) | 22 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | RYR2 | C4053736 | Catecholaminergic Polymorphic Ventricular Tachycardia Type 1 | 9 | CLINGEN |
Hgene | RYR2 | C1832931 | ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2 | 6 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | RYR2 | C0007194 | Hypertrophic Cardiomyopathy | 2 | CLINGEN |
Hgene | RYR2 | C0042514 | Tachycardia, Ventricular | 2 | CTD_human |
Hgene | RYR2 | C0340485 | Familial ventricular tachycardia | 2 | CTD_human |
Hgene | RYR2 | C2677794 | Stress-induced polymorphic ventricular tachycardia | 2 | CTD_human |
Hgene | RYR2 | C0023976 | Long QT Syndrome | 1 | GENOMICS_ENGLAND |
Hgene | RYR2 | C0039231 | Tachycardia | 1 | CTD_human |
Hgene | RYR2 | C0080203 | Tachyarrhythmia | 1 | CTD_human |
Hgene | RYR2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | RYR2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | RYR2 | C0349788 | Arrhythmogenic Right Ventricular Dysplasia | 1 | GENOMICS_ENGLAND |
Hgene | RYR2 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |
Hgene | RYR2 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Tgene | MTR | C1855128 | Methylcobalamin Deficiency, CblG Type | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | MTR | C0011570 | Mental Depression | 2 | PSYGENET |
Tgene | MTR | C0011581 | Depressive disorder | 2 | PSYGENET |
Tgene | MTR | C0013221 | Drug toxicity | 2 | CTD_human |
Tgene | MTR | C0041755 | Adverse reaction to drug | 2 | CTD_human |
Tgene | MTR | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Tgene | MTR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | MTR | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
Tgene | MTR | C0008924 | Cleft upper lip | 1 | CTD_human |
Tgene | MTR | C0008925 | Cleft Palate | 1 | CTD_human |
Tgene | MTR | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Tgene | MTR | C0018939 | Hematological Disease | 1 | CTD_human |
Tgene | MTR | C0021364 | Male infertility | 1 | CTD_human |
Tgene | MTR | C0024299 | Lymphoma | 1 | CTD_human |
Tgene | MTR | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
Tgene | MTR | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MTR | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
Tgene | MTR | C0079745 | Lymphoma, Large-Cell, Follicular | 1 | CTD_human |
Tgene | MTR | C0079758 | Lymphoma, Mixed-Cell, Follicular | 1 | CTD_human |
Tgene | MTR | C0079765 | Lymphoma, Small Cleaved-Cell, Follicular | 1 | CTD_human |
Tgene | MTR | C0162429 | Malnutrition | 1 | CTD_human |
Tgene | MTR | C0268611 | Arakawa syndrome 2 | 1 | GENOMICS_ENGLAND |
Tgene | MTR | C0270612 | Leukoencephalopathy | 1 | CTD_human |
Tgene | MTR | C0559031 | Functional Gastrointestinal Disorders | 1 | CTD_human |
Tgene | MTR | C0588008 | Severe depression | 1 | PSYGENET |
Tgene | MTR | C0678222 | Breast Carcinoma | 1 | CTD_human |
Tgene | MTR | C0848676 | Subfertility, Male | 1 | CTD_human |
Tgene | MTR | C0917731 | Male sterility | 1 | CTD_human |
Tgene | MTR | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
Tgene | MTR | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | MTR | C1565321 | Cholera Infantum | 1 | CTD_human |
Tgene | MTR | C1837218 | Cleft palate, isolated | 1 | CTD_human |
Tgene | MTR | C1858991 | Childhood Ataxia with Central Nervous System Hypomyelinization | 1 | CTD_human |
Tgene | MTR | C1866558 | Neural tube defect, folate-sensitive | 1 | CTD_human;GENOMICS_ENGLAND |
Tgene | MTR | C1956130 | Lymphoma, Follicular, Grade 1 | 1 | CTD_human |
Tgene | MTR | C1956131 | Lymphoma, Follicular, Grade 3 | 1 | CTD_human |
Tgene | MTR | C1956132 | Lymphoma, Follicular, Grade 2 | 1 | CTD_human |
Tgene | MTR | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |