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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:S100A16-RPL14 (FusionGDB2 ID:78374)

Fusion Gene Summary for S100A16-RPL14

Fusion gene summary

Fusion gene information	Fusion gene name: S100A16-RPL14
	Fusion gene ID: 78374
		Hgene	Tgene
	Gene symbol	S100A16	RPL14
	Gene ID	388697	9045
	Gene name	hornerin	ribosomal protein L14
	Synonyms	FLG3\|S100A16\|S100a18	CAG-ISL-7\|CTG-B33\|L14\|RL14\|hRL14
	Cytomap	1q21.3	3p22.1
	Type of gene	protein-coding	protein-coding
	Description	hornerinfilaggrin family member 3intermediate filament-associated protein	60S ribosomal protein L14large ribosomal subunit protein eL14
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000368704, ENST00000368706, ENST00000368703, ENST00000368705, ENST00000474991,	ENST00000338970, ENST00000396203, ENST00000416518, ENST00000461368,
Fusion gene scores	* DoF score	5 X 9 X 5=225	16 X 21 X 11=3696
	# samples	11	29
	** MAII score	log2(11/225*10)=-1.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/3696*10)=-3.67183995140112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: S100A16 [Title/Abstract] AND RPL14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPL14(40503534)-S100A16(153579639), # samples:1 S100A16(153579644)-RPL14(40503533), # samples:1 S100A16(153579646)-RPL14(40503537), # samples:1 S100A16(153579624)-RPL14(40503529), # samples:1 S100A16(153579624)-RPL14(40503526), # samples:1 S100A16(153579629)-RPL14(40503539), # samples:1 S100A16(153579629)-RPL14(40503530), # samples:1 S100A16(153579629)-RPL14(40503533), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	S100A16	GO:0043163	cell envelope organization	21282207

Fusion gene breakpoints across S100A16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPL14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3994-01A	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
ChimerDB4	COAD	TCGA-CM-4743-01A	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
ChimerDB4	READ	TCGA-AG-3594	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
ChimerDB4	READ	TCGA-AG-4005	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
ChimerDB4	STAD	TCGA-BR-4267-01A	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
ChimerDB4	STAD	TCGA-BR-4267-01A	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
ChimerDB4	UCEC	TCGA-D1-A167-01A	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+

Top

Fusion Gene ORF analysis for S100A16-RPL14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579644	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579646	-	RPL14	chr3	40503537	+
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503529	+
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579624	-	RPL14	chr3	40503526	+
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503539	+
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503530	+
intron-3CDS	ENST00000368704	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368704	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368704	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368704	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368706	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368706	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368706	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368706	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368703	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368703	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368703	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368703	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368705	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000368705	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000368705	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-intron	ENST00000368705	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000474991	ENST00000338970	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3CDS	ENST00000474991	ENST00000396203	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-3UTR	ENST00000474991	ENST00000416518	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+
intron-intron	ENST00000474991	ENST00000461368	S100A16	chr1	153579629	-	RPL14	chr3	40503533	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for S100A16-RPL14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for S100A16-RPL14

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for S100A16-RPL14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for S100A16-RPL14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for S100A16-RPL14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for S100A16-RPL14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RPL14	C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene	RPL14	C0030567	Parkinson Disease	1	CTD_human
Tgene	RPL14	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Tgene	RPL14	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Tgene	RPL14	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Tgene	RPL14	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Tgene	RPL14	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human