FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SAMD14-CCNYL1 (FusionGDB2 ID:78582)

Fusion Gene Summary for SAMD14-CCNYL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SAMD14-CCNYL1
Fusion gene ID: 78582
HgeneTgene
Gene symbol

SAMD14

CCNYL1

Gene ID

201191

151195

Gene namesterile alpha motif domain containing 14cyclin Y like 1
Synonyms--
Cytomap

17q21.33

2q33.3

Type of geneprotein-codingprotein-coding
Descriptionsterile alpha motif domain-containing protein 14SAM domain-containing protein 14cyclin-Y-like protein 1
Modification date2020032020200313
UniProtAcc.

Q8N7R7

Ensembl transtripts involved in fusion geneENST00000330175, ENST00000503131, 
ENST00000503734, 		ENST00000392209, 
ENST00000420822, ENST00000295414, 
ENST00000339882, ENST00000468768, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SAMD14 [Title/Abstract] AND CCNYL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSAMD14(48202280)-CCNYL1(208589523), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SAMD14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCNYL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OTSAMD14chr17

48202280

-CCNYL1chr2

208589523

+


Top

Fusion Gene ORF analysis for SAMD14-CCNYL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000330175ENST00000392209SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000330175ENST00000420822SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000330175ENST00000295414SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000330175ENST00000339882SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000330175ENST00000468768SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
In-frameENST00000503131ENST00000392209SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000503131ENST00000420822SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000503131ENST00000295414SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000503131ENST00000339882SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
5CDS-intronENST00000503131ENST00000468768SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
intron-3CDSENST00000503734ENST00000392209SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
intron-intronENST00000503734ENST00000420822SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
intron-intronENST00000503734ENST00000295414SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
intron-intronENST00000503734ENST00000339882SAMD14chr17

48202280

-CCNYL1chr2

208589523

+
intron-intronENST00000503734ENST00000468768SAMD14chr17

48202280

-CCNYL1chr2

208589523

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000330175SAMD14chr1748202280-ENST00000392209CCNYL1chr2208589523+19883613181220300
ENST00000503131SAMD14chr1748202280-ENST00000392209CCNYL1chr2208589523+20484213781280300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000330175ENST00000392209SAMD14chr1748202280-CCNYL1chr2208589523+0.0014741710.9985259
ENST00000503131ENST00000392209SAMD14chr1748202280-CCNYL1chr2208589523+0.0015728130.9984273

Top

Fusion Genomic Features for SAMD14-CCNYL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SAMD14chr1748202280-CCNYL1chr2208589523+0.0001562160.9998437
SAMD14chr1748202280-CCNYL1chr2208589523+0.0001562160.9998437

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SAMD14-CCNYL1


check button Go to

FGviewer for the breakpoints of chr17:48202280-chr2:208589523

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCNYL1

Q8N7R7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCNYL1chr17:48202280chr2:208589523ENST00000295414010145_26773.33333333333333360.0DomainNote=Cyclin N-terminal
TgeneCCNYL1chr17:48202280chr2:208589523ENST0000033988208145_26773.33333333333333309.0DomainNote=Cyclin N-terminal
TgeneCCNYL1chr17:48202280chr2:208589523ENST00000392209111145_2673.3333333333333335290.0DomainNote=Cyclin N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSAMD14chr17:48202280chr2:208589523ENST00000330175-210377_41714.333333333333334418.0Coiled coilOntology_term=ECO:0000255
HgeneSAMD14chr17:48202280chr2:208589523ENST00000503131-211377_41714.333333333333334446.0Coiled coilOntology_term=ECO:0000255
HgeneSAMD14chr17:48202280chr2:208589523ENST00000330175-210326_38914.333333333333334418.0DomainSAM
HgeneSAMD14chr17:48202280chr2:208589523ENST00000503131-211326_38914.333333333333334446.0DomainSAM


Top

Fusion Gene Sequence for SAMD14-CCNYL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000330175_ENST00000392209_TCGA-L5-A4OT_SAMD14_chr17_48202280_-_CCNYL1_chr2_208589523_length(transcript)=1988nt_BP=361nt
CGCACACGCACACACACACGGAGCATCCTCCCGTCAGGTCTCCTGGTCCAGCCCCGCCCGCGCCTCCTGCTTCCAGCGAACCTGTTCCCT
CTCCCCACATCCCCCGCCCTCCATCTCCCCCGGCTCTGGGACCCTTCCCGCCGACCTCACCCCCACCCCCGGGATGGAGCGGCTCGAGCC
CGCCCGGAGCCCCCCGCGGCCGGGGTGACGGTCCCCCCACCCCTCTCCTGCCCGGCCCCCGCCTCGAGCACCATGGGCCTGAGGGGTTCC
CGGGGCGCCAGACGCTGAAGATGACCGATGCCGGAGCTCTCTTGAGTCATGGCTTCTTCAAAGCTCCGAGAACCCGTGGATGAAGTTTTT
GATTTAGCTTTGGAGTCAAACCCTTCTGACCATCCAAGGGCAAGCACAATTTTCCTGAGCAAATCTCAAACGGATGTGCGAGAAAAGAGG
AAGAGCAACCATTTGAACCATGTATCTCCAGGGCAGCTTACTAAAAAGTATAGCTCATGCTCAACAATATTTCTAGATGACAGCACAGTC
AGCCAGCCTAATCTTAGAACCACAGTAAAATGTGTGACCTTAGCAATATATTACCACATAAAGAACAGAGATGCAAATAGATCCCTGGAT
ATTTTTGATGAGAGATCACATCCACTTACACGAGAAAAAGTTCCAGAGGAATACTTTAAGCATGATCCTGAGCACAAATTTATTTACAGA
TTTGTTCGTACTCTTTTTAGTGCTGCACAGCTAACAGCTGAATGTGCAATAGTAACTTTGGTTTACTTAGAAAGGCTTTTAACTTATGCT
GAAATCGACATTTGTCCCACCAACTGGAAAAGGATTGTTCTGGGAGCCATTCTTCTTGCCTCCAAGGTTTGGGACGATCAGGCTGTATGG
AATGTGGACTACTGCCAGATCCTCAAGGACATTACAGTTGAGGACATGAATGAAATGGAAAGGCATTTTCTGGAGCTTCTTCAGTTTAAT
ATTAATGTTCCTGCCAGTGTTTATGCCAAATACTACTTTGACCTTCGCTCCTTAGCAGATGACAACAACCTGAATTTTCTATTTGCTCCT
CTTAGCAAAGAAAGAGCACAGAACCTAGAGGCTATTTCTAGATTGTGTGAAGACAAAGACTTGTGTAGAGCCGCTATGAGAAGGTCTTTC
AGTGCTGATAACTTCATTGGTATTCAGCGCTCTAAAGCCATCCTCTCTTAAAAGGAGAAATGAGGGGTTATAACGTCATGGGACCTTCAT
CTACAAAGACTGGAGAAATACCACCTTTCCTGCTCAAAAACCAGCAAAATTAGTGTTTTCATCAAAAGGAAAGATCTCAAATTCAAGAGA
CTCATGGACAACAAGGATTATACTCCACAGGAAAGAATGGGACCTTGTCAATGCAACAAAACACTCTTCTGTCCTTTTTAATGTAAACAG
AGTTACAAAAACCACTCCAAAGTGAAGGCTCCCATCCTACACACAGATATTTGCTTACTGTGTGGGCCGATAGCTGTGAACTATGTAAGG
TTTTTTAAACAATAGTTTAAATTTTTAGACTTTAAAGACACTAACCATATAACTTTTATGTTTCTTCCAGTTTCTCTCCCTCCCCCCGCA
TTTTGCTGCATATGCCTTTAAAATCAATGCAGTATTACCATTAAAACATGGGACTCTAACTAAAGCCACTTAGGAGCAGACAGCAGCGTT
GTTAGGTACTGAAGGGTTCTTCCTCCCTACTGTTACCATTGAAGCTGCTAGTCATTGGCAATCATTTTAAACCAAAAAGCTGCTGGATAA
CATTTGTCATTCATATTCTTTGCAAGCATTACTTTAGCATTTTAGCATGTTTGGGGTCATAAACAGAGGAAGTATCAGTTATTGATATCT
ACTTCTATTGGAGTCCATGTTGCATTTCTTGTGAACTATAAATGGTGCTTCTCATTTTCTGATAATTTTTCTCTTGCTAAATAAATGTAT

>In-frame_ENST00000330175_ENST00000392209_TCGA-L5-A4OT_SAMD14_chr17_48202280_-_CCNYL1_chr2_208589523_length(amino acids)=300AA_start in transcript=318_stop in transcript=1220
MASSKLREPVDEVFDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTVKCVTLAI
YYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGA
ILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLC

--------------------------------------------------------------
>In-frame_ENST00000503131_ENST00000392209_TCGA-L5-A4OT_SAMD14_chr17_48202280_-_CCNYL1_chr2_208589523_length(transcript)=2048nt_BP=421nt
GGCGCTCGCTCTTCGCTCTTCTCTCTCTCTCTCTCTCTGTCACACACACACACACGCACACGCACACGCACACACACACGGAGCATCCTC
CCGTCAGGTCTCCTGGTCCAGCCCCGCCCGCGCCTCCTGCTTCCAGCGAACCTGTTCCCTCTCCCCACATCCCCCGCCCTCCATCTCCCC
CGGCTCTGGGACCCTTCCCGCCGACCTCACCCCCACCCCCGGGATGGAGCGGCTCGAGCCCGCCCGGAGCCCCCCGCGGCCGGGGTGACG
GTCCCCCCACCCCTCTCCTGCCCGGCCCCCGCCTCGAGCACCATGGGCCTGAGGGGTTCCCGGGGCGCCAGACGCTGAAGATGACCGATG
CCGGAGCTCTCTTGAGTCATGGCTTCTTCAAAGCTCCGAGAACCCGTGGATGAAGTTTTTGATTTAGCTTTGGAGTCAAACCCTTCTGAC
CATCCAAGGGCAAGCACAATTTTCCTGAGCAAATCTCAAACGGATGTGCGAGAAAAGAGGAAGAGCAACCATTTGAACCATGTATCTCCA
GGGCAGCTTACTAAAAAGTATAGCTCATGCTCAACAATATTTCTAGATGACAGCACAGTCAGCCAGCCTAATCTTAGAACCACAGTAAAA
TGTGTGACCTTAGCAATATATTACCACATAAAGAACAGAGATGCAAATAGATCCCTGGATATTTTTGATGAGAGATCACATCCACTTACA
CGAGAAAAAGTTCCAGAGGAATACTTTAAGCATGATCCTGAGCACAAATTTATTTACAGATTTGTTCGTACTCTTTTTAGTGCTGCACAG
CTAACAGCTGAATGTGCAATAGTAACTTTGGTTTACTTAGAAAGGCTTTTAACTTATGCTGAAATCGACATTTGTCCCACCAACTGGAAA
AGGATTGTTCTGGGAGCCATTCTTCTTGCCTCCAAGGTTTGGGACGATCAGGCTGTATGGAATGTGGACTACTGCCAGATCCTCAAGGAC
ATTACAGTTGAGGACATGAATGAAATGGAAAGGCATTTTCTGGAGCTTCTTCAGTTTAATATTAATGTTCCTGCCAGTGTTTATGCCAAA
TACTACTTTGACCTTCGCTCCTTAGCAGATGACAACAACCTGAATTTTCTATTTGCTCCTCTTAGCAAAGAAAGAGCACAGAACCTAGAG
GCTATTTCTAGATTGTGTGAAGACAAAGACTTGTGTAGAGCCGCTATGAGAAGGTCTTTCAGTGCTGATAACTTCATTGGTATTCAGCGC
TCTAAAGCCATCCTCTCTTAAAAGGAGAAATGAGGGGTTATAACGTCATGGGACCTTCATCTACAAAGACTGGAGAAATACCACCTTTCC
TGCTCAAAAACCAGCAAAATTAGTGTTTTCATCAAAAGGAAAGATCTCAAATTCAAGAGACTCATGGACAACAAGGATTATACTCCACAG
GAAAGAATGGGACCTTGTCAATGCAACAAAACACTCTTCTGTCCTTTTTAATGTAAACAGAGTTACAAAAACCACTCCAAAGTGAAGGCT
CCCATCCTACACACAGATATTTGCTTACTGTGTGGGCCGATAGCTGTGAACTATGTAAGGTTTTTTAAACAATAGTTTAAATTTTTAGAC
TTTAAAGACACTAACCATATAACTTTTATGTTTCTTCCAGTTTCTCTCCCTCCCCCCGCATTTTGCTGCATATGCCTTTAAAATCAATGC
AGTATTACCATTAAAACATGGGACTCTAACTAAAGCCACTTAGGAGCAGACAGCAGCGTTGTTAGGTACTGAAGGGTTCTTCCTCCCTAC
TGTTACCATTGAAGCTGCTAGTCATTGGCAATCATTTTAAACCAAAAAGCTGCTGGATAACATTTGTCATTCATATTCTTTGCAAGCATT
ACTTTAGCATTTTAGCATGTTTGGGGTCATAAACAGAGGAAGTATCAGTTATTGATATCTACTTCTATTGGAGTCCATGTTGCATTTCTT

>In-frame_ENST00000503131_ENST00000392209_TCGA-L5-A4OT_SAMD14_chr17_48202280_-_CCNYL1_chr2_208589523_length(amino acids)=300AA_start in transcript=378_stop in transcript=1280
MASSKLREPVDEVFDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPGQLTKKYSSCSTIFLDDSTVSQPNLRTTVKCVTLAI
YYHIKNRDANRSLDIFDERSHPLTREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPTNWKRIVLGA
ILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPASVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLC

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SAMD14-CCNYL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SAMD14-CCNYL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SAMD14-CCNYL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource