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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SBF2-PRMT3 (FusionGDB2 ID:78830)

Fusion Gene Summary for SBF2-PRMT3

check button Fusion gene summary
Fusion gene informationFusion gene name: SBF2-PRMT3
Fusion gene ID: 78830
HgeneTgene
Gene symbol

SBF2

PRMT3

Gene ID

81846

10196

Gene nameSET binding factor 2protein arginine methyltransferase 3
SynonymsCMT4B2|DENND7B|MTMR13HRMT1L3
Cytomap

11p15.4

11p15.1

Type of geneprotein-codingprotein-coding
Descriptionmyotubularin-related protein 13DENN/MADD domain containing 7Binactive phosphatidylinositol 3-phosphatase 13protein arginine N-methyltransferase 3HMT1 hnRNP methyltransferase-like 3heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000256190, ENST00000527019, 
ENST00000331079, ENST00000437750, 
Fusion gene scores* DoF score27 X 17 X 10=45907 X 6 X 4=168
# samples 309
** MAII scorelog2(30/4590*10)=-3.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SBF2 [Title/Abstract] AND PRMT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSBF2(10315562)-PRMT3(20473676), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRMT3

GO:0031397

negative regulation of protein ubiquitination

18573314


check buttonFusion gene breakpoints across SBF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRMT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-4132-01ASBF2chr11

10315562

-PRMT3chr11

20473676

+
ChimerDB4LUSCTCGA-37-4132SBF2chr11

10315561

-PRMT3chr11

20473675

+
ChimerDB4LUSCTCGA-37-4132SBF2chr11

10315562

-PRMT3chr11

20473676

+
ChimerDB4LUSCTCGA-37-4132-01ASBF2chr11

10315562

-PRMT3chr11

20473676

+


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Fusion Gene ORF analysis for SBF2-PRMT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000256190ENST00000331079SBF2chr11

10315562

-PRMT3chr11

20473676

+
In-frameENST00000256190ENST00000437750SBF2chr11

10315562

-PRMT3chr11

20473676

+
intron-3CDSENST00000527019ENST00000331079SBF2chr11

10315562

-PRMT3chr11

20473676

+
intron-3CDSENST00000527019ENST00000437750SBF2chr11

10315562

-PRMT3chr11

20473676

+
In-frameENST00000256190ENST00000331079SBF2chr11

10315561

-PRMT3chr11

20473675

+
In-frameENST00000256190ENST00000437750SBF2chr11

10315561

-PRMT3chr11

20473675

+
intron-3CDSENST00000527019ENST00000331079SBF2chr11

10315561

-PRMT3chr11

20473675

+
intron-3CDSENST00000527019ENST00000437750SBF2chr11

10315561

-PRMT3chr11

20473675

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256190SBF2chr1110315562-ENST00000331079PRMT3chr1120473676+1636193175795206
ENST00000256190SBF2chr1110315562-ENST00000437750PRMT3chr1120473676+1091193175795206
ENST00000256190SBF2chr1110315561-ENST00000331079PRMT3chr1120473675+1636193175795206
ENST00000256190SBF2chr1110315561-ENST00000437750PRMT3chr1120473675+1091193175795206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256190ENST00000331079SBF2chr1110315562-PRMT3chr1120473676+0.0007992120.99920076
ENST00000256190ENST00000437750SBF2chr1110315562-PRMT3chr1120473676+0.0022357580.9977642
ENST00000256190ENST00000331079SBF2chr1110315561-PRMT3chr1120473675+0.0007992120.99920076
ENST00000256190ENST00000437750SBF2chr1110315561-PRMT3chr1120473675+0.0022357580.9977642

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Fusion Genomic Features for SBF2-PRMT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SBF2chr1110315561-PRMT3chr1120473675+2.41E-091
SBF2chr1110315561-PRMT3chr1120473675+2.41E-091
SBF2chr1110315561-PRMT3chr1120473675+2.41E-091
SBF2chr1110315561-PRMT3chr1120473675+2.41E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SBF2-PRMT3


check button Go to

FGviewer for the breakpoints of chr11:10315562-chr11:20473676

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSBF2chr11:10315561chr11:20473675ENST00000256190-1401108_158418.3333333333333321850.0DomainMyotubularin phosphatase
HgeneSBF2chr11:10315561chr11:20473675ENST00000256190-1401743_184718.3333333333333321850.0DomainPH
HgeneSBF2chr11:10315561chr11:20473675ENST00000256190-140191_32418.3333333333333321850.0DomaincDENN
HgeneSBF2chr11:10315561chr11:20473675ENST00000256190-140326_42718.3333333333333321850.0DomaindDENN
HgeneSBF2chr11:10315561chr11:20473675ENST00000256190-1407_17218.3333333333333321850.0DomainuDENN
HgeneSBF2chr11:10315561chr11:20473675ENST00000256190-140871_95718.3333333333333321850.0DomainGRAM
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1401108_158418.3333333333333321850.0DomainMyotubularin phosphatase
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1401743_184718.3333333333333321850.0DomainPH
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-140191_32418.3333333333333321850.0DomaincDENN
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-140326_42718.3333333333333321850.0DomaindDENN
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-1407_17218.3333333333333321850.0DomainuDENN
HgeneSBF2chr11:10315562chr11:20473676ENST00000256190-140871_95718.3333333333333321850.0DomainGRAM
TgenePRMT3chr11:10315561chr11:20473675ENST00000331079916217_531331.0532.0DomainSAM-dependent MTase PRMT-type
TgenePRMT3chr11:10315561chr11:20473675ENST00000437750714217_531269.0470.0DomainSAM-dependent MTase PRMT-type
TgenePRMT3chr11:10315562chr11:20473676ENST00000331079916217_531331.0532.0DomainSAM-dependent MTase PRMT-type
TgenePRMT3chr11:10315562chr11:20473676ENST00000437750714217_531269.0470.0DomainSAM-dependent MTase PRMT-type
TgenePRMT3chr11:10315561chr11:20473675ENST0000033107991648_71331.0532.0Zinc fingerNote=C2H2-type
TgenePRMT3chr11:10315561chr11:20473675ENST0000043775071448_71269.0470.0Zinc fingerNote=C2H2-type
TgenePRMT3chr11:10315562chr11:20473676ENST0000033107991648_71331.0532.0Zinc fingerNote=C2H2-type
TgenePRMT3chr11:10315562chr11:20473676ENST0000043775071448_71269.0470.0Zinc fingerNote=C2H2-type


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Fusion Gene Sequence for SBF2-PRMT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000256190_ENST00000331079_TCGA-37-4132-01A_SBF2_chr11_10315562_-_PRMT3_chr11_20473676_length(transcript)=1636nt_BP=193nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC
GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA
TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG
TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT
GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA
AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA
GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG
CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC
TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT
GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC
ATTTACATTGGCCTATATTTGGAAGAGAGATAGTCTTTTGTTTTTAATAAGTTTCTTACTATAAATTTTAAACAAATTGGTTAGTTATTT
GGATATTTTATTAAACTAGTAACACAGGTACTACACATTTTATTATGGACTCCTCTGAGGAGGAGTTTTTAATTGTATTTGCTAGAAAAT
CAGGATGTAATAAAGATTTGTATAAAAAAACTAAAATATGGAAAAGAGCTTCAGCCTTCATATACAAATCATATATGCAGACAGCCTAGT
TGATTATCTAGCATACTTAGGGTTCTCATTTTGTAGTTTCTTCCCTCTTTGTGACTATTCCTTAGCCTTATAGATTTCTAGTACTGCCCA
GGAAATCTAATTTCAATACATTTATCCTAGGTTTCATGAAAGTTTTTAAAGATTGGGATAAATATGTACTTATTTACTAACGTATTATCT
TTTTCAAACCAGATTTATGTGCAAAGGTTAAACATGTAACTGTTACTAAGCAGTCTATAAAGTTGTCATTTACAATTACTGATTCAATTT

>In-frame_ENST00000256190_ENST00000331079_TCGA-37-4132-01A_SBF2_chr11_10315562_-_PRMT3_chr11_20473676_length(amino acids)=206AA_start in transcript=175_stop in transcript=795
MTTRSQGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISE
PCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTV

--------------------------------------------------------------
>In-frame_ENST00000256190_ENST00000437750_TCGA-37-4132-01A_SBF2_chr11_10315562_-_PRMT3_chr11_20473676_length(transcript)=1091nt_BP=193nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC
GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA
TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG
TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT
GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA
AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA
GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG
CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC
TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT
GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC

>In-frame_ENST00000256190_ENST00000437750_TCGA-37-4132-01A_SBF2_chr11_10315562_-_PRMT3_chr11_20473676_length(amino acids)=206AA_start in transcript=175_stop in transcript=795
MTTRSQGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISE
PCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTV

--------------------------------------------------------------
>In-frame_ENST00000256190_ENST00000331079_TCGA-37-4132_SBF2_chr11_10315561_-_PRMT3_chr11_20473675_length(transcript)=1636nt_BP=193nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC
GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA
TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG
TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT
GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA
AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA
GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG
CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC
TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT
GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC
ATTTACATTGGCCTATATTTGGAAGAGAGATAGTCTTTTGTTTTTAATAAGTTTCTTACTATAAATTTTAAACAAATTGGTTAGTTATTT
GGATATTTTATTAAACTAGTAACACAGGTACTACACATTTTATTATGGACTCCTCTGAGGAGGAGTTTTTAATTGTATTTGCTAGAAAAT
CAGGATGTAATAAAGATTTGTATAAAAAAACTAAAATATGGAAAAGAGCTTCAGCCTTCATATACAAATCATATATGCAGACAGCCTAGT
TGATTATCTAGCATACTTAGGGTTCTCATTTTGTAGTTTCTTCCCTCTTTGTGACTATTCCTTAGCCTTATAGATTTCTAGTACTGCCCA
GGAAATCTAATTTCAATACATTTATCCTAGGTTTCATGAAAGTTTTTAAAGATTGGGATAAATATGTACTTATTTACTAACGTATTATCT
TTTTCAAACCAGATTTATGTGCAAAGGTTAAACATGTAACTGTTACTAAGCAGTCTATAAAGTTGTCATTTACAATTACTGATTCAATTT

>In-frame_ENST00000256190_ENST00000331079_TCGA-37-4132_SBF2_chr11_10315561_-_PRMT3_chr11_20473675_length(amino acids)=206AA_start in transcript=175_stop in transcript=795
MTTRSQGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISE
PCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTV

--------------------------------------------------------------
>In-frame_ENST00000256190_ENST00000437750_TCGA-37-4132_SBF2_chr11_10315561_-_PRMT3_chr11_20473675_length(transcript)=1091nt_BP=193nt
GGTTGTCAAACATGGCTGAAGCGCTGCCGCTGCCGCTACTGCCGCTGCAGGGAAAATGCTGAGCCCTCCCGGGCCGGGTGGGCGGCGGCG
GCGAGGGCGGCGACGGGGACCCGCTTCCCGAGCGCGGCGGCGGCGGCCATGGCCCGGCTGGCTGACTACTTCATCGTGGTAGGCTATGAC
CACGAGAAGCCAGGGCTATTTTCTTCTGTTTGAGTCTATGTTAGATTCTGTCCTTTATGCAAAGAACAAATACTTGGCAAAAGGAGGCTC
GGTCTACCCTGACATTTGCACTATCAGCCTTGTAGCAGTGAGTGATGTGAATAAACATGCTGATAGAATTGCTTTTTGGGATGATGTCTA
TGGCTTCAAGATGTCCTGCATGAAGAAAGCAGTTATTCCAGAAGCTGTTGTGGAAGTTTTAGATCCGAAGACTCTTATTTCAGAACCTTG
TGGTATTAAGCATATAGATTGCCATACGACGTCTATCTCAGATTTGGAATTTTCATCAGATTTTACCCTGAAAATCACAAGGACATCCAT
GTGCACGGCAATTGCTGGCTACTTTGATATATATTTTGAGAAGAATTGCCACAACAGGGTCGTGTTCTCTACGGGCCCTCAGAGCACCAA
AACACACTGGAAACAAACAGTATTTCTACTGGAAAAACCATTTTCAGTTAAAGCAGGTGAAGCCTTGAAAGGAAAGGTCACAGTTCACAA
GAGTAAGAAAGATCCACGTTCTCTCACCGTGACCCTCACGTTGAATAATTCAACTCAAACTTATGGTCTCCAGTGAAACAGCCATAAAAG
CACACTACCTTGTAGTTTTTAATGTGGGGGTAGAGTGGGTCAGCAGGAGGGAGCTGGTTTTATGTGAGCAGATGGATGGATGATGGACCC
TTTCCTAATGAGCCTCCTCAATAAGAGAGAAGTTCTCATTGTGGGAATCTGACATAGTTCAGCTGAGGAAGAGAATCAGCTGATCCTCAT
GGTCTGCCACGTAATCATTTTCTTAGACGTTTGCTCCACCAGATTTAACCAAATGTAACTCCCACATTGAGTTTATCTATATTGAAAATC

>In-frame_ENST00000256190_ENST00000437750_TCGA-37-4132_SBF2_chr11_10315561_-_PRMT3_chr11_20473675_length(amino acids)=206AA_start in transcript=175_stop in transcript=795
MTTRSQGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISE
PCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SBF2-PRMT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SBF2-PRMT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SBF2-PRMT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSBF2C1858278Charcot-Marie-Tooth disease, Type 4B22CTD_human;GENOMICS_ENGLAND