FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SCAF11-CNIH4 (FusionGDB2 ID:78910)

Fusion Gene Summary for SCAF11-CNIH4

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAF11-CNIH4
Fusion gene ID: 78910
HgeneTgene
Gene symbol

SCAF11

CNIH4

Gene ID

9169

29097

Gene nameSR-related CTD associated factor 11cornichon family AMPA receptor auxiliary protein 4
SynonymsCASP11|SFRS2IP|SIP1|SRRP129|SRSF2IPCNIH-4|CNIH2|HSPC163
Cytomap

12q12

1q42.11

Type of geneprotein-codingprotein-coding
Descriptionprotein SCAF11CTD-associated SR protein 11SC35-interacting protein 1SFRS2-interacting proteinSR-related and CTD-associated factor 11SRSF2-interacting proteinrenal carcinoma antigen NY-REN-40serine/arginine-rich splicing factor 2-interacting proteinprotein cornichon homolog 4cornichon homolog 4
Modification date2020031320200313
UniProtAcc.

Q9P003

Ensembl transtripts involved in fusion geneENST00000550629, ENST00000465950, 
ENST00000369367, ENST00000549162, 
ENST00000419565, ENST00000395454, 
ENST00000395453, 		ENST00000465271, 
ENST00000366858, ENST00000366857, 
ENST00000468318, ENST00000366856, 
Fusion gene scores* DoF score13 X 12 X 4=62410 X 7 X 8=560
# samples 1313
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/560*10)=-2.10691520391651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCAF11 [Title/Abstract] AND CNIH4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCAF11(46339032)-CNIH4(224553581), # samples:1
Anticipated loss of major functional domain due to fusion event.SCAF11-CNIH4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SCAF11-CNIH4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCAF11

GO:0000245

spliceosomal complex assembly

9447963

HgeneSCAF11

GO:0000375

RNA splicing, via transesterification reactions

9447963

HgeneSCAF11

GO:0008380

RNA splicing

9447963


check buttonFusion gene breakpoints across SCAF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CNIH4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315486SCAF11chr12

46339032

-CNIH4chr1

224553581

+


Top

Fusion Gene ORF analysis for SCAF11-CNIH4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000550629ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000550629ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000550629ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000550629ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000550629ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000465950ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000465950ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000465950ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000465950ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000465950ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+
In-frameENST00000369367ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
In-frameENST00000369367ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
In-frameENST00000369367ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000369367ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000369367ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000549162ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000549162ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000549162ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000549162ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000549162ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+
Frame-shiftENST00000419565ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
Frame-shiftENST00000419565ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
Frame-shiftENST00000419565ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000419565ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000419565ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000395454ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000395454ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000395454ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000395454ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000395454ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000395453ENST00000465271SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000395453ENST00000366858SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3CDSENST00000395453ENST00000366857SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000395453ENST00000468318SCAF11chr12

46339032

-CNIH4chr1

224553581

+
intron-3UTRENST00000395453ENST00000366856SCAF11chr12

46339032

-CNIH4chr1

224553581

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369367SCAF11chr1246339032-ENST00000465271CNIH4chr1224553581+4609697234833199
ENST00000369367SCAF11chr1246339032-ENST00000366858CNIH4chr1224553581+1194697234815193
ENST00000369367SCAF11chr1246339032-ENST00000366857CNIH4chr1224553581+4468697234833199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369367ENST00000465271SCAF11chr1246339032-CNIH4chr1224553581+0.0031548210.99684525
ENST00000369367ENST00000366858SCAF11chr1246339032-CNIH4chr1224553581+0.0039383560.9960616
ENST00000369367ENST00000366857SCAF11chr1246339032-CNIH4chr1224553581+0.0034061820.9965938

Top

Fusion Genomic Features for SCAF11-CNIH4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SCAF11chr1246339031-CNIH4chr1224553580+5.18E-050.99994814
SCAF11chr1246339031-CNIH4chr1224553580+5.18E-050.99994814

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SCAF11-CNIH4


check button Go to

FGviewer for the breakpoints of chr12:46339032-chr1:224553581

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNIH4

Q9P003

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750). {ECO:0000269|PubMed:24405750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAF11chr12:46339032chr1:224553581ENST00000369367-61541_82154.333333333333341464.0Zinc fingerRING-type%3B degenerate
HgeneSCAF11chr12:46339032chr1:224553581ENST00000419565-61541_82154.333333333333341464.0Zinc fingerRING-type%3B degenerate
TgeneCNIH4chr12:46339032chr1:224553581ENST0000036685714118_13846.093.0TransmembraneHelical
TgeneCNIH4chr12:46339032chr1:224553581ENST000003668571457_7746.093.0TransmembraneHelical
TgeneCNIH4chr12:46339032chr1:224553581ENST0000046527115118_13846.0140.0TransmembraneHelical
TgeneCNIH4chr12:46339032chr1:224553581ENST000004652711557_7746.0140.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAF11chr12:46339032chr1:224553581ENST00000369367-6151225_1285154.333333333333341464.0Compositional biasNote=Pro-rich
HgeneSCAF11chr12:46339032chr1:224553581ENST00000369367-615841_985154.333333333333341464.0Compositional biasNote=Arg-rich
HgeneSCAF11chr12:46339032chr1:224553581ENST00000419565-6151225_1285154.333333333333341464.0Compositional biasNote=Pro-rich
HgeneSCAF11chr12:46339032chr1:224553581ENST00000419565-615841_985154.333333333333341464.0Compositional biasNote=Arg-rich
HgeneSCAF11chr12:46339032chr1:224553581ENST00000465950-151225_128501149.0Compositional biasNote=Pro-rich
HgeneSCAF11chr12:46339032chr1:224553581ENST00000465950-15841_98501149.0Compositional biasNote=Arg-rich
HgeneSCAF11chr12:46339032chr1:224553581ENST00000465950-1541_8201149.0Zinc fingerRING-type%3B degenerate
TgeneCNIH4chr12:46339032chr1:224553581ENST00000366857145_2546.093.0TransmembraneHelical
TgeneCNIH4chr12:46339032chr1:224553581ENST00000465271155_2546.0140.0TransmembraneHelical


Top

Fusion Gene Sequence for SCAF11-CNIH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000369367_ENST00000465271_ERR315486_SCAF11_chr12_46339032_-_CNIH4_chr1_224553581_length(transcript)=4609nt_BP=697nt
TGGCTTAAGCCGCGCGGAGCAGCGCAACCTGGGTCGCTCCCTGCTTCGCCGCCGCCTCCGGACCGAGCCAGCGGAGTCAGTGTCCTAGAG
ACCCTGTAACACCACAAAGCGGACGAAGGAGTCCATGTTGGGGAACTTGGCAGCGGAGTGACTGGGACCTGGGAACCTACTGTGGGGCCG
CGGCCGGACCGAGCGCCTCGACCTCGGTCTGAGGAAACCCTTTTCCAAAGAGAAATGAAGAAGAAAACTGTATGTACCCTAAATATGGGA
GATAAGAAGTATGAAGACATGGAAGGTGAAGAAAACGGAGATAATACTATTTCCACTGGTCTGTTGTACAGTGAGGCTGACAGATGCCCA
ATATGTCTTAATTGTCTATTAGAAAAGGAAGTTGGTTTTCCAGAAAGCTGTAATCATGTCTTCTGTATGACTTGTATTCTTAAATGGGCA
GAGACACTGGCTTCATGTCCTATTGACCGTAAACCTTTTCAGGCAGTGTTTAAATTCAGTGCATTGGAAGGTTATGTTAAGGTTCAAGTA
AAAAAACAGCTGAGAGAAACAAAAGACAAGAAAAATGAAAACTCATTTGAGAAACAGGTCTCCTGTCATGAAAATTCTAAAAGCTGTATA
AGAAGAAAAGCCATCGTAAGAGAAGATCTATTAAGTGCAAAAGTTTGTGACTTGAAGTGGATACATATGGGTAATTCCAGAATTGATTGG
CCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCTGTTGCCACTTGGAATATATATCG
ATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAATCGAGGGCAGCTGAAGTCACACATGAAAGAAGC
CATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAGTATGATCTTAGCTTTGATAAATGACTGAAGCTGGAGAAG
CCGTGGTTGAAGTCAGCCTACACTACAGTGCACAGTTGAGGAGCCAGAGACTTCTTAAATCATCCTTAGAACCGTGACCATAGCAGTATA
TATTTTCCTCTTGGAACAAAAAACTATTTTTGCTGTATTTTTACCATATAAAGTATTTAAAAAACATGAATTGAGTTTCTGTAGATTTCT
AGTTCTCAACTTTAGCCTGAACGCCAACACTTGAAGGTGTTTTTCATCCTCTGTATGTTGAAGGTGGTTATTTGTATGTAGGAACAGGAC
TGCCATCCCAGCTTTGCATGCCAAAGAAATAAAGAACACACTTTAAAGGGCAAACTGAAGAGATGAGCGAGCAAAGGTGCCCTTCAGGTC
TACTGAAAAGTTAGAGTACAAAACAACACTGTTGATCTGGACAAAAGAAGAAAAATTACCCTTTTTGCTTGTGTTGTGACAACTTCATTT
AATATGGTTTAAAGATTTATGAGACTGTCAGCTAAAAGTCTTTTCACAAGAATGTCAACAGAGAATGGCATCTCAAAATATATATATTTC
TTTGCACAATTTGTGAAACCTTATAAGCCATTTTCCCCAGGTACAATGTAGTTCCTGCTGATAGAAAGGAAATATTTTGTCAAGAGCTTT
CATTTAAAAGCTACTACCTCCACAATCACCCCCAAACCCAGAAAATCCCCACTGGCTCTTGCCAGTCTGGTTTTCGTATTGCAGTTATTC
CAATTGTATTTGATCTCCCTGATAACGTATTTTCATGGGTTTGGGTAGAAGATGCTAATCAGATTAGAAGCAGGAATAGTTATTTGCTGT
CTGTGAAATTGAGCCTTTTGGTGCGCCACGTGGTGCCAGATCAACACTTCTATCCCTCTGCACTGACCACGTTGTGAACTGGGAGACCAA
ATGCAAGCCATTTCATGGACATAGCAATATACAACCAAACTCTGTTCCTTGGAGTTATATTGTAAACTCTTGCAGGTGGGAGAGCAGTTC
ACCTCCTTAGCTCTGTTTGCCAGCTCTTACAGGGTAAAATAAACCTGGCAATTTATCCTCAGTCCTAGTTTGTGGTTTAATGTTGCTATC
TTAAGCACTGGCATTTGGGCAAAACATGACTGTGTTCTGTGGGAGAATCCAAAGGCATTATTCACTCTAGTTGAGATAGAATTGGGTGGC
TAAACAGGGTGTGTGGTACCCAAAAGATTAAATGTTACATGTCCTTTTAGTCCTTGACCAGGTCTAGCCTTGGCAGAAGCAAGGGAGCCA
CTAAGCCAAACTCCCTGTGCAGACAGACCATGTTTCAAGGCTGGAAGTAGTGCCCTGGCAACACACAAAAGGAACGGTGAAATGGTAGGC
AAAGTGAACTTGGCTCTGCTGGCCTCTTTGGGGTCACAGAAATTGCTCCTTGTGGTAATCTTATATTTCTGTCAGGCACAGGGCCAAGAA
GCTGTGTAACAGACATTACTTTGCTTGCATCTCTTTTTCATACCTTTTCCCTCTGAGGCAGCTTTTGCTTAGAAAACAGTCCCTTCACTC
TGCCTTTCCTCCTAACTTCCTGTGCCTCTTCATGTTCTGCTCAAGCTTTTTAAAGCAACGAAGCTGTTGGAGAACTTAAATCCTTGCAAC
TGAGAGATAAGCTACTTAAAGGCGGTAGAGATCTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGT
GGTGTGATCTCAGCTCACTGCAACCTCTGCTTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACGGCTAGC
TACTCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAACGATCTG
CCTGCCTTGGTCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTGCGCCTGGCCATGTAGATGACTTTTGACCAAAATGTTTCACCTT
CTCATTCAGATATTCTTAGTAACCAAAACAGTGACTCATGCAGTTGAGAGAGCCTTTGGGCTGTCAGTTTACAGTACATCAGGCTTGCTG
AGGCTAAGCAAATCAGAAAGGTGCCATGTTTATAACAGAGGTCAAAGCTCCTTACTTCTGAAACATTAGCTGTGGTTAAAAACAAAAACT
CTTCCTTCTTGTATTGCTTGTCTATCAAAGCCAGGAAAGTGGGGGATCACTGTAGTTAAATTTTTTTTTTTTTTAATTAGAGACAGAGTC
TTGCCCTGTCGCCCAAGCTGGAGTGCACTGGCGCAATCGTGGTACACTGCAGCCTTGAACTCCTGGACTCAAGCAGTCCTCCTGCCTCAG
CTTCCCAAGTAGTTGGGAGTAGGTGCACACCACCATGCCCAGCGAATTTTTTGTAGAGACAGAGGTCTTGCTATGTTGCCTAGGCTGGTA
TCAAAATTACTGGCCTCAAGCGATTCTCCTGCCTCGGCCTCCCAGATGTTGGGATTACTGGTGTGAGCCACCACGCCCAGCTCAAAAACA
ATTTTTTTAGGGGCACTTCTACAAATCATGAAAGGGGGATAAAAGCACTGACTTTAAAAAGCCATGTTTAAGATGCTATAAATGTTCTCC
CCTTTTCATTGATTGGAGAGTTGTAGAGGACCTTAGAGATCATTTTGTCTAACTCCCTCATCCCAAAGATAAACTGAGGCCTAGAGATCG
TTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCT
AGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGC
TGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACAT
CTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACT
GGGAACATCTGAATGCTGAGGCTTAGTCCAGTGTTCTCTCTCCCTTACCACTCCTCTTCCCCTTCCCTCTATAATGGCAGTACCCAGGGC
CCGGTCCATAGACTACTATCGAGTGCTCCTATGTGCATCTTAGTACGTATCATTTTCCCTTGCCTTTTTCCTTCTATCCTTTCAGTGGTA
GCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGATGCAGCTCAGTTCATCAAAGCCTAGCAG
GTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAACCTGACCTGGTCTTTGAAGTTAAGAGCTAAGAAAGCTTCC
TATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTTATTTGTATGCAATTAATCACTCTTAGATTGTATGTTCCT
GGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTGGCACCTAACACAGTGCCTTGCACACAAACAATAAATGAT

>In-frame_ENST00000369367_ENST00000465271_ERR315486_SCAF11_chr12_46339032_-_CNIH4_chr1_224553581_length(amino acids)=199AA_start in transcript=234_stop in transcript=833
MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFK
FSALEGYVKVQVKKQLRETKDKKNENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHMGNSRIDWPYHCHCITAHVIALVHLP

--------------------------------------------------------------
>In-frame_ENST00000369367_ENST00000366858_ERR315486_SCAF11_chr12_46339032_-_CNIH4_chr1_224553581_length(transcript)=1194nt_BP=697nt
TGGCTTAAGCCGCGCGGAGCAGCGCAACCTGGGTCGCTCCCTGCTTCGCCGCCGCCTCCGGACCGAGCCAGCGGAGTCAGTGTCCTAGAG
ACCCTGTAACACCACAAAGCGGACGAAGGAGTCCATGTTGGGGAACTTGGCAGCGGAGTGACTGGGACCTGGGAACCTACTGTGGGGCCG
CGGCCGGACCGAGCGCCTCGACCTCGGTCTGAGGAAACCCTTTTCCAAAGAGAAATGAAGAAGAAAACTGTATGTACCCTAAATATGGGA
GATAAGAAGTATGAAGACATGGAAGGTGAAGAAAACGGAGATAATACTATTTCCACTGGTCTGTTGTACAGTGAGGCTGACAGATGCCCA
ATATGTCTTAATTGTCTATTAGAAAAGGAAGTTGGTTTTCCAGAAAGCTGTAATCATGTCTTCTGTATGACTTGTATTCTTAAATGGGCA
GAGACACTGGCTTCATGTCCTATTGACCGTAAACCTTTTCAGGCAGTGTTTAAATTCAGTGCATTGGAAGGTTATGTTAAGGTTCAAGTA
AAAAAACAGCTGAGAGAAACAAAAGACAAGAAAAATGAAAACTCATTTGAGAAACAGGTCTCCTGTCATGAAAATTCTAAAAGCTGTATA
AGAAGAAAAGCCATCGTAAGAGAAGATCTATTAAGTGCAAAAGTTTGTGACTTGAAGTGGATACATATGGGTAATTCCAGAATTGATTGG
CCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCTGTTGCCACTTGGAATATATATCG
TGGTAGCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGATGCAGCTCAGTTCATCAAAGCCT
AGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAACCTGACCTGGTCTTTGAAGTTAAGAGCTAAGAAAG
CTTCCTATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTTATTTGTATGCAATTAATCACTCTTAGATTGTATG
TTCCTGGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTGGCACCTAACACAGTGCCTTGCACACAAACAATAA

>In-frame_ENST00000369367_ENST00000366858_ERR315486_SCAF11_chr12_46339032_-_CNIH4_chr1_224553581_length(amino acids)=193AA_start in transcript=234_stop in transcript=815
MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFK
FSALEGYVKVQVKKQLRETKDKKNENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHMGNSRIDWPYHCHCITAHVIALVHLP

--------------------------------------------------------------
>In-frame_ENST00000369367_ENST00000366857_ERR315486_SCAF11_chr12_46339032_-_CNIH4_chr1_224553581_length(transcript)=4468nt_BP=697nt
TGGCTTAAGCCGCGCGGAGCAGCGCAACCTGGGTCGCTCCCTGCTTCGCCGCCGCCTCCGGACCGAGCCAGCGGAGTCAGTGTCCTAGAG
ACCCTGTAACACCACAAAGCGGACGAAGGAGTCCATGTTGGGGAACTTGGCAGCGGAGTGACTGGGACCTGGGAACCTACTGTGGGGCCG
CGGCCGGACCGAGCGCCTCGACCTCGGTCTGAGGAAACCCTTTTCCAAAGAGAAATGAAGAAGAAAACTGTATGTACCCTAAATATGGGA
GATAAGAAGTATGAAGACATGGAAGGTGAAGAAAACGGAGATAATACTATTTCCACTGGTCTGTTGTACAGTGAGGCTGACAGATGCCCA
ATATGTCTTAATTGTCTATTAGAAAAGGAAGTTGGTTTTCCAGAAAGCTGTAATCATGTCTTCTGTATGACTTGTATTCTTAAATGGGCA
GAGACACTGGCTTCATGTCCTATTGACCGTAAACCTTTTCAGGCAGTGTTTAAATTCAGTGCATTGGAAGGTTATGTTAAGGTTCAAGTA
AAAAAACAGCTGAGAGAAACAAAAGACAAGAAAAATGAAAACTCATTTGAGAAACAGGTCTCCTGTCATGAAAATTCTAAAAGCTGTATA
AGAAGAAAAGCCATCGTAAGAGAAGATCTATTAAGTGCAAAAGTTTGTGACTTGAAGTGGATACATATGGGTAATTCCAGAATTGATTGG
CCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCTGTTGCCACTTGGAATATATATCG
TATGATCTTAGCTTTGATAAATGACTGAAGCTGGAGAAGCCGTGGTTGAAGTCAGCCTACACTACAGTGCACAGTTGAGGAGCCAGAGAC
TTCTTAAATCATCCTTAGAACCGTGACCATAGCAGTATATATTTTCCTCTTGGAACAAAAAACTATTTTTGCTGTATTTTTACCATATAA
AGTATTTAAAAAACATGAATTGAGTTTCTGTAGATTTCTAGTTCTCAACTTTAGCCTGAACGCCAACACTTGAAGGTGTTTTTCATCCTC
TGTATGTTGAAGGTGGTTATTTGTATGTAGGAACAGGACTGCCATCCCAGCTTTGCATGCCAAAGAAATAAAGAACACACTTTAAAGGGC
AAACTGAAGAGATGAGCGAGCAAAGGTGCCCTTCAGGTCTACTGAAAAGTTAGAGTACAAAACAACACTGTTGATCTGGACAAAAGAAGA
AAAATTACCCTTTTTGCTTGTGTTGTGACAACTTCATTTAATATGGTTTAAAGATTTATGAGACTGTCAGCTAAAAGTCTTTTCACAAGA
ATGTCAACAGAGAATGGCATCTCAAAATATATATATTTCTTTGCACAATTTGTGAAACCTTATAAGCCATTTTCCCCAGGTACAATGTAG
TTCCTGCTGATAGAAAGGAAATATTTTGTCAAGAGCTTTCATTTAAAAGCTACTACCTCCACAATCACCCCCAAACCCAGAAAATCCCCA
CTGGCTCTTGCCAGTCTGGTTTTCGTATTGCAGTTATTCCAATTGTATTTGATCTCCCTGATAACGTATTTTCATGGGTTTGGGTAGAAG
ATGCTAATCAGATTAGAAGCAGGAATAGTTATTTGCTGTCTGTGAAATTGAGCCTTTTGGTGCGCCACGTGGTGCCAGATCAACACTTCT
ATCCCTCTGCACTGACCACGTTGTGAACTGGGAGACCAAATGCAAGCCATTTCATGGACATAGCAATATACAACCAAACTCTGTTCCTTG
GAGTTATATTGTAAACTCTTGCAGGTGGGAGAGCAGTTCACCTCCTTAGCTCTGTTTGCCAGCTCTTACAGGGTAAAATAAACCTGGCAA
TTTATCCTCAGTCCTAGTTTGTGGTTTAATGTTGCTATCTTAAGCACTGGCATTTGGGCAAAACATGACTGTGTTCTGTGGGAGAATCCA
AAGGCATTATTCACTCTAGTTGAGATAGAATTGGGTGGCTAAACAGGGTGTGTGGTACCCAAAAGATTAAATGTTACATGTCCTTTTAGT
CCTTGACCAGGTCTAGCCTTGGCAGAAGCAAGGGAGCCACTAAGCCAAACTCCCTGTGCAGACAGACCATGTTTCAAGGCTGGAAGTAGT
GCCCTGGCAACACACAAAAGGAACGGTGAAATGGTAGGCAAAGTGAACTTGGCTCTGCTGGCCTCTTTGGGGTCACAGAAATTGCTCCTT
GTGGTAATCTTATATTTCTGTCAGGCACAGGGCCAAGAAGCTGTGTAACAGACATTACTTTGCTTGCATCTCTTTTTCATACCTTTTCCC
TCTGAGGCAGCTTTTGCTTAGAAAACAGTCCCTTCACTCTGCCTTTCCTCCTAACTTCCTGTGCCTCTTCATGTTCTGCTCAAGCTTTTT
AAAGCAACGAAGCTGTTGGAGAACTTAAATCCTTGCAACTGAGAGATAAGCTACTTAAAGGCGGTAGAGATCTTTTTTTTTTTTTTTTTG
AGATGGGGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTTTCTGGGTTCAAGCGATTCT
CCTGCCTCAGCCTCCCAAGTAGCTGGGATTACGGCTAGCTACTCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTT
GGCCAGGCTGGTCTCAAACTCCTGACCTCAAACGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTGCGCC
TGGCCATGTAGATGACTTTTGACCAAAATGTTTCACCTTCTCATTCAGATATTCTTAGTAACCAAAACAGTGACTCATGCAGTTGAGAGA
GCCTTTGGGCTGTCAGTTTACAGTACATCAGGCTTGCTGAGGCTAAGCAAATCAGAAAGGTGCCATGTTTATAACAGAGGTCAAAGCTCC
TTACTTCTGAAACATTAGCTGTGGTTAAAAACAAAAACTCTTCCTTCTTGTATTGCTTGTCTATCAAAGCCAGGAAAGTGGGGGATCACT
GTAGTTAAATTTTTTTTTTTTTTAATTAGAGACAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCACTGGCGCAATCGTGGTACACTGCA
GCCTTGAACTCCTGGACTCAAGCAGTCCTCCTGCCTCAGCTTCCCAAGTAGTTGGGAGTAGGTGCACACCACCATGCCCAGCGAATTTTT
TGTAGAGACAGAGGTCTTGCTATGTTGCCTAGGCTGGTATCAAAATTACTGGCCTCAAGCGATTCTCCTGCCTCGGCCTCCCAGATGTTG
GGATTACTGGTGTGAGCCACCACGCCCAGCTCAAAAACAATTTTTTTAGGGGCACTTCTACAAATCATGAAAGGGGGATAAAAGCACTGA
CTTTAAAAAGCCATGTTTAAGATGCTATAAATGTTCTCCCCTTTTCATTGATTGGAGAGTTGTAGAGGACCTTAGAGATCATTTTGTCTA
ACTCCCTCATCCCAAAGATAAACTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTT
CAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAG
AGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTG
AGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCT
GAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCTTAGTCCAGTGTTCTCTCTCCCTTACCAC
TCCTCTTCCCCTTCCCTCTATAATGGCAGTACCCAGGGCCCGGTCCATAGACTACTATCGAGTGCTCCTATGTGCATCTTAGTACGTATC
ATTTTCCCTTGCCTTTTTCCTTCTATCCTTTCAGTGGTAGCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGC
GAAATCCAAGATGCAGCTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAAC
CTGACCTGGTCTTTGAAGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTT
ATTTGTATGCAATTAATCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTG

>In-frame_ENST00000369367_ENST00000366857_ERR315486_SCAF11_chr12_46339032_-_CNIH4_chr1_224553581_length(amino acids)=199AA_start in transcript=234_stop in transcript=833
MKKKTVCTLNMGDKKYEDMEGEENGDNTISTGLLYSEADRCPICLNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPIDRKPFQAVFK
FSALEGYVKVQVKKQLRETKDKKNENSFEKQVSCHENSKSCIRRKAIVREDLLSAKVCDLKWIHMGNSRIDWPYHCHCITAHVIALVHLP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SCAF11-CNIH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SCAF11-CNIH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SCAF11-CNIH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource