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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCAF8-IL20RA (FusionGDB2 ID:78949)

Fusion Gene Summary for SCAF8-IL20RA

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAF8-IL20RA
Fusion gene ID: 78949
HgeneTgene
Gene symbol

SCAF8

IL20RA

Gene ID

22828

53832

Gene nameSR-related CTD associated factor 8interleukin 20 receptor subunit alpha
SynonymsRBM16CRF2-8|IL-20R-alpha|IL-20R1|IL-20RA
Cytomap

6q25.2

6q23.3

Type of geneprotein-codingprotein-coding
DescriptionSR-related and CTD-associated factor 8CDC5L complex-associated protein 7RNA-binding motif protein 16SR-like CTD-associated factor 8protein SCAF8interleukin-20 receptor subunit alphaclass II cytokine receptor ZCYTOR7cytokine receptor family 2 member 8interleukin 20 receptor alpha subunitinterleukin 20 receptor, alphainterleukin-20 receptor I
Modification date2020031420200313
UniProtAcc.

Q9UHF4

Ensembl transtripts involved in fusion geneENST00000367178, ENST00000461219, 
ENST00000417268, ENST00000367186, 
ENST00000316649, ENST00000367748, 
ENST00000541547, ENST00000468393, 
ENST00000367746, 
Fusion gene scores* DoF score14 X 14 X 10=19603 X 2 X 3=18
# samples 195
** MAII scorelog2(19/1960*10)=-3.36678233067162
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/18*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCAF8 [Title/Abstract] AND IL20RA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCAF8(155114110)-IL20RA(137338240), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCAF8

GO:0032786

positive regulation of DNA-templated transcription, elongation

31104839

HgeneSCAF8

GO:2000805

negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

31104839


check buttonFusion gene breakpoints across SCAF8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL20RA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YVSCAF8chr6

155114110

+IL20RAchr6

137338240

-
ChimerDB4SARCTCGA-X9-A971-01ASCAF8chr6

155114110

+IL20RAchr6

137338240

-
ChimerDB4SARCTCGA-X9-A971-01ASCAF8chr6

155114110

+IL20RAchr6

137359268

-
ChimerDB4SARCTCGA-HB-A3YV-01ASCAF8chr6

155114110

-IL20RAchr6

137338240

-


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Fusion Gene ORF analysis for SCAF8-IL20RA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367178ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367178ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367178ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367178ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367178ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137338240

-
intron-3CDSENST00000461219ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137338240

-
intron-5UTRENST00000461219ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137338240

-
intron-5UTRENST00000461219ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137338240

-
intron-5UTRENST00000461219ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137338240

-
intron-5UTRENST00000461219ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137338240

-
In-frameENST00000417268ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000417268ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000417268ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000417268ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000417268ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137338240

-
In-frameENST00000367186ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367186ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367186ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367186ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-5UTRENST00000367186ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137338240

-
5CDS-intronENST00000367178ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367178ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367178ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367178ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367178ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137359268

-
intron-intronENST00000461219ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137359268

-
intron-intronENST00000461219ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137359268

-
intron-intronENST00000461219ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137359268

-
intron-intronENST00000461219ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137359268

-
intron-intronENST00000461219ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000417268ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000417268ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000417268ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000417268ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000417268ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367186ENST00000316649SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367186ENST00000367748SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367186ENST00000541547SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367186ENST00000468393SCAF8chr6

155114110

+IL20RAchr6

137359268

-
5CDS-intronENST00000367186ENST00000367746SCAF8chr6

155114110

+IL20RAchr6

137359268

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367178SCAF8chr6155114110+ENST00000316649IL20RAchr6137338240-421210515762624682
ENST00000417268SCAF8chr6155114110+ENST00000316649IL20RAchr6137338240-3868707132280755
ENST00000367186SCAF8chr6155114110+ENST00000316649IL20RAchr6137338240-384168072253748

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367178ENST00000316649SCAF8chr6155114110+IL20RAchr6137338240-0.0004511050.99954885
ENST00000417268ENST00000316649SCAF8chr6155114110+IL20RAchr6137338240-0.0003861870.9996138
ENST00000367186ENST00000316649SCAF8chr6155114110+IL20RAchr6137338240-0.0004707950.99952924

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Fusion Genomic Features for SCAF8-IL20RA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCAF8-IL20RA


check button Go to

FGviewer for the breakpoints of chr6:155114110-chr6:137338240

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IL20RA

Q9UHF4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAF8chr6:155114110chr6:137338240ENST00000367178+5201_139158.333333333333341272.0DomainCID
HgeneSCAF8chr6:155114110chr6:137338240ENST00000417268+6211_139158.333333333333341272.0DomainCID
TgeneIL20RAchr6:155114110chr6:137338240ENST0000031664907353_35629.333333333333332554.0Compositional biasNote=Poly-Glu
TgeneIL20RAchr6:155114110chr6:137338240ENST0000036774806353_3560443.0Compositional biasNote=Poly-Glu
TgeneIL20RAchr6:155114110chr6:137338240ENST0000031664907136_24229.333333333333332554.0DomainFibronectin type-III 2
TgeneIL20RAchr6:155114110chr6:137338240ENST000003166490737_13529.333333333333332554.0DomainFibronectin type-III 1
TgeneIL20RAchr6:155114110chr6:137338240ENST0000036774806136_2420443.0DomainFibronectin type-III 2
TgeneIL20RAchr6:155114110chr6:137338240ENST000003677480637_1350443.0DomainFibronectin type-III 1
TgeneIL20RAchr6:155114110chr6:137338240ENST0000031664907272_55329.333333333333332554.0Topological domainCytoplasmic
TgeneIL20RAchr6:155114110chr6:137338240ENST000003166490730_25029.333333333333332554.0Topological domainExtracellular
TgeneIL20RAchr6:155114110chr6:137338240ENST0000036774806272_5530443.0Topological domainCytoplasmic
TgeneIL20RAchr6:155114110chr6:137338240ENST000003677480630_2500443.0Topological domainExtracellular
TgeneIL20RAchr6:155114110chr6:137338240ENST0000031664907251_27129.333333333333332554.0TransmembraneHelical
TgeneIL20RAchr6:155114110chr6:137338240ENST0000036774806251_2710443.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAF8chr6:155114110chr6:137338240ENST00000367178+5201120_1182158.333333333333341272.0Compositional biasNote=Arg-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000367178+520193_371158.333333333333341272.0Compositional biasNote=Gln-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000367178+520397_459158.333333333333341272.0Compositional biasNote=Arg-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000367178+520635_1064158.333333333333341272.0Compositional biasNote=Pro-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000417268+6211120_1182158.333333333333341272.0Compositional biasNote=Arg-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000417268+621193_371158.333333333333341272.0Compositional biasNote=Gln-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000417268+621397_459158.333333333333341272.0Compositional biasNote=Arg-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000417268+621635_1064158.333333333333341272.0Compositional biasNote=Pro-rich
HgeneSCAF8chr6:155114110chr6:137338240ENST00000367178+520477_551158.333333333333341272.0DomainRRM
HgeneSCAF8chr6:155114110chr6:137338240ENST00000417268+621477_551158.333333333333341272.0DomainRRM


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Fusion Gene Sequence for SCAF8-IL20RA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000367178_ENST00000316649_TCGA-HB-A3YV_SCAF8_chr6_155114110_+_IL20RA_chr6_137338240_length(transcript)=4212nt_BP=1051nt
CGGCCGCCGGGGCTCGCACGGTCCAGTCGCCAGGGGGCGCGCTAGCCGGCGCCGCGGATCCCCGAACTGCGCGGCCCGACTCGAGTCCGC
CATATTGGATGCCGCAGCCGCTGCTGCCAGCGCTTCCTCCTCTGTCTTCGCCGAGCGGGGCTGGTTCCTGCGGCCCGAGCGGCGGGGAGG
TGAAACAGGAGCCCGTCGGAGGAAGGGGCAGAAGGGAGTGGAGAGTGTAGGGGAAGGGGCTAGAGGGAGGGGGACCGAAACGGAGCGGGG
CAGAGAAGAGAAGGCGCCGCGGCCCAGCCCCTCCCCCGCCCGCCGCCGACCCGCCCCGGCAGCGCCTCTGTTCCCTAGAACGGCGCTCCC
CCCGCCCTAGCGGCCATGCCGGTGCCGCTCTGCCGCTGAGGGAGCCCTTCCCCGCCAGCGCGTGCCCTTCCACTCCGCCCCGAGGTCGCA
GCGGCCCGCTCTCCCGCCAGCGCCCCCTCCTCGCGGCCACGCAGCAGCCCGCGTCTCGCTCTCCCCACCCAGTGCAGTGGCCGCCGCCTC
TTCCGCCGCCGGGCTCGGGGCCTCCGCAGCGACAACATGGAGGCCGTGAAGACCTTCAATAGCGAGTTGTATTCCCTGAATGACTATAAA
CCACCCATTTCGAAAGCGAAAATGACCCAAATTACTAAGGCAGCCATCAAAGCTATTAAGTTCTATAAACATGTGGTACAGAGTGTTGAG
AAGTTTATTCAGAAATGTAAACCAGAATACAAAGTACCTGGACTTTATGTTATTGACTCCATTGTGCGACAATCCCGACATCAGTTTGGT
CAAGAAAAGGATGTGTTTGCACCCAGATTTAGTAATAACATCATTAGCACTTTCCAGAATTTATATCGTTGCCCTGGGGATGACAAGAGT
AAAATAGTGAGAGTACTAAACTTATGGCAGAAGAATAATGTATTTAAGAGTGAGATTATTCAGCCCCTTTTGGATATGGCAGCCGGGATT
CCGCCTCCAGTTGTCACACCTGTTTTGGCCAGCACTACCACTGCTATGAGCAATACTCCAGTTCCCTGTGTCTCTGGTGGTTTGCCTAAA
CCTGCAAACATCACCTTCTTATCCATCAACATGAAGAATGTCCTACAATGGACTCCACCAGAGGGTCTTCAAGGAGTTAAAGTTACTTAC
ACTGTGCAGTATTTCATATATGGGCAAAAGAAATGGCTGAATAAATCAGAATGCAGAAATATCAATAGAACCTACTGTGATCTTTCTGCT
GAAACTTCTGACTACGAACACCAGTATTATGCCAAAGTTAAGGCCATTTGGGGAACAAAGTGTTCCAAATGGGCTGAAAGTGGACGGTTC
TATCCTTTTTTAGAAACACAAATTGGCCCACCAGAGGTGGCACTGACTACAGATGAGAAGTCCATTTCTGTTGTCCTGACAGCTCCAGAG
AAGTGGAAGAGAAATCCAGAAGACCTTCCTGTTTCCATGCAACAAATATACTCCAATCTGAAGTATAACGTGTCTGTGTTGAATACTAAA
TCAAACAGAACGTGGTCCCAGTGTGTGACCAACCACACGCTGGTGCTCACCTGGCTGGAGCCGAACACTCTTTACTGCGTACACGTGGAG
TCCTTCGTCCCAGGGCCCCCTCGCCGTGCTCAGCCTTCTGAGAAGCAGTGTGCCAGGACTTTGAAAGATCAATCATCAGAGTTCAAGGCT
AAAATCATCTTCTGGTATGTTTTGCCCGTATCTATTACCGTGTTTCTTTTTTCTGTGATGGGCTATTCCATCTACCGATATATCCACGTT
GGCAAAGAGAAACACCCAGCAAATTTGATTTTGATTTATGGAAATGAATTTGACAAAAGATTCTTTGTGCCTGCTGAAAAAATCGTGATT
AACTTTATCACCCTCAATATCTCGGATGATTCTAAAATTTCTCATCAGGATATGAGTTTACTGGGAAAAAGCAGTGATGTATCCAGCCTT
AATGATCCTCAGCCCAGCGGGAACCTGAGGCCCCCTCAGGAGGAAGAGGAGGTGAAACATTTAGGGTATGCTTCGCATTTGATGGAAATT
TTTTGTGACTCTGAAGAAAACACGGAAGGTACTTCTCTCACCCAGCAAGAGTCCCTCAGCAGAACAATACCCCCGGATAAAACAGTCATT
GAATATGAATATGATGTCAGAACCACTGACATTTGTGCGGGGCCTGAAGAGCAGGAGCTCAGTTTGCAGGAGGAGGTGTCCACACAAGGA
ACATTATTGGAGTCGCAGGCAGCGTTGGCAGTCTTGGGCCCGCAAACGTTACAGTACTCATACACCCCTCAGCTCCAAGACTTAGACCCC
CTGGCGCAGGAGCACACAGACTCGGAGGAGGGGCCGGAGGAAGAGCCATCGACGACCCTGGTCGACTGGGATCCCCAAACTGGCAGGCTG
TGTATTCCTTCGCTGTCCAGCTTCGACCAGGATTCAGAGGGCTGCGAGCCTTCTGAGGGGGATGGGCTCGGAGAGGAGGGTCTTCTATCT
AGACTCTATGAGGAGCCGGCTCCAGACAGGCCACCAGGAGAAAATGAAACCTATCTCATGCAATTCATGGAGGAATGGGGGTTATATGTG
CAGATGGAAAACTGATGCCAACACTTCCTTTTGCCTTTTGTTTCCTGTGCAAACAAGTGAGTCACCCCTTTGATCCCAGCCATAAAGTAC
CTGGGATGAAAGAAGTTTTTTCCAGTTTGTCAGTGTCTGTGAGAATTACTTATTTCTTTTCTCTATTCTCATAGCACGTGTGTGATTGGT
TCATGCATGTAGGTCTCTTAACAATGATGGTGGGCCTCTGGAGTCCAGGGGCTGGCCGGTTGTTCTATGCAGAGAAAGCAGTCAATAAAT
GTTTGCCAGACTGGGTGCAGAATTTATTCAGGTGGGTGTACTCTGGCCTCTTGGTTCATTATTTTCAAACAAGCACACTTGTACAATTAT
TTTCTGGGTACTTCCCATATGCACATAGCACTGTAAAAAATATTTCCCAAAGATCACTCATTTTATAAATACCACTTTTTCAGAATTGGG
TTTATTGCGAGCAGGAGGAGATACTTAAAACATGCACATATACCAGGTTGGTGGTAAGTTGGTCGCATGTGAAAACCTCAACTATTTAAT
CATCATGATTCATATTTTGAGTGAATACATCAGGCACAGACCTTCATGATATCACACACTCTTGGCTACTTTAAGAGGCCATCTTTAATA
CTTTATGAGTAGTTCTGGAGTGTAAACATAAACGAGTATTCTTTTGTAGTCAGAAAAGTGTCCTCTCAATAATTTAGTAGGGGCTTATTG
TCTCTCAAAACTAACCTAAAAGAAAATGACACATTTTATAATAGAATATTACATTTATTTCTGGAAGTGTGTTTTCAAAAAGATATTTAC
ATAGTCTGTAAACTAGAAAGTGTTAGGTAAAGCTCTAGGTTACTGTGTTACTATTATAATATTAAACATTCGAATAGGCAGTCGTTCAAA
GACTCTTTGGAATATCTATGAATGAATATCCTCTATTCTTATAATATTAAAACCCATAAGTAAATATAGGACATACAAGAGAAATGAGTT
AAATGACTATGTAAGGGAGAGTTTATTAAAATTTGATGAAATTTACTGTAGGAACTAAACTATGCCATAAAACAATAGCTTTCTAGTTCA
TTTCCAGTAACTGTTCCCATCTCCTTTACCACTTGTTAAGAAAATTAAATTCTTCAGTCACGCTGCTTTAAAATGGGACAAAATCTATTA
AGTTGAACCATATATAATTGTGGATATTTGGCTGTTTTTAATCTGACAAGCAGTAACTTCATATGGTTTGCCTTAATATATATTTGTTTT
AGTCATGAACTCATAATCCATTGATGCTCTTTCATGAGAAGAGATATCACCCATATTTCCTTATTGATATTATTGGTACAGGCAGACAAC
CCTGGTAGGAGAGATGGATTCTGGGGTCATGACCTTTCGTGATTATCCGCAAATGCAAACAGTTTCAGATCTAATGGTTTAATTTAGGGA
GTAATTATATTAATCAGAGTGTTCTGTTATTCTCAATCTTTATAGAAACGATTCTGCTGGTTTTGAAGAACAGATGTATTACACTAACTG

>In-frame_ENST00000367178_ENST00000316649_TCGA-HB-A3YV_SCAF8_chr6_155114110_+_IL20RA_chr6_137338240_length(amino acids)=682AA_start in transcript=576_stop in transcript=2624
MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSN
NIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPVPCVSGGLPKPANITFLSINMK
NVLQWTPPEGLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQYYAKVKAIWGTKCSKWAESGRFYPFLETQIGPPE
VALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQIYSNLKYNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHVESFVPGPPRRAQP
SEKQCARTLKDQSSEFKAKIIFWYVLPVSITVFLFSVMGYSIYRYIHVGKEKHPANLILIYGNEFDKRFFVPAEKIVINFITLNISDDSK
ISHQDMSLLGKSSDVSSLNDPQPSGNLRPPQEEEEVKHLGYASHLMEIFCDSEENTEGTSLTQQESLSRTIPPDKTVIEYEYDVRTTDIC
AGPEEQELSLQEEVSTQGTLLESQAALAVLGPQTLQYSYTPQLQDLDPLAQEHTDSEEGPEEEPSTTLVDWDPQTGRLCIPSLSSFDQDS

--------------------------------------------------------------
>In-frame_ENST00000417268_ENST00000316649_TCGA-HB-A3YV_SCAF8_chr6_155114110_+_IL20RA_chr6_137338240_length(transcript)=3868nt_BP=707nt
GCGGATCCCCGAACTGCGCGGCCCGACTCGAGTCCGCCATATTGGATGCCGCAGCCGCTGCTGCCAGCGCTTCCTCCTCTGTCTTCGCCG
AGCGGGGCTGGTTCCTGCGGCCCGAGCGGCGGGGAGCGCCCCCTCCTCGCGGCCACGCAGCAGCCCGCGTCTCGCTCTCCCCACCCAGTG
CAGTGGCCGCCGCCTCTTCCGCCGCCGGGCTCGGGGCCTCCGCAGCGACAACATGGAGGCCGTGAAGACCTTCAATAGCGAGTTGTATTC
CCTGAATGACTATAAACCACCCATTTCGAAAGCGAAAATGACCCAAATTACTAAGGCAGCCATCAAAGCTATTAAGTTCTATAAACATGT
GGTACAGAGTGTTGAGAAGTTTATTCAGAAATGTAAACCAGAATACAAAGTACCTGGACTTTATGTTATTGACTCCATTGTGCGACAATC
CCGACATCAGTTTGGTCAAGAAAAGGATGTGTTTGCACCCAGATTTAGTAATAACATCATTAGCACTTTCCAGAATTTATATCGTTGCCC
TGGGGATGACAAGAGTAAAATAGTGAGAGTACTAAACTTATGGCAGAAGAATAATGTATTTAAGAGTGAGATTATTCAGCCCCTTTTGGA
TATGGCAGCCGGGATTCCGCCTCCAGTTGTCACACCTGTTTTGGCCAGCACTACCACTGCTATGAGCAATACTCCAGTTCCCTGTGTCTC
TGGTGGTTTGCCTAAACCTGCAAACATCACCTTCTTATCCATCAACATGAAGAATGTCCTACAATGGACTCCACCAGAGGGTCTTCAAGG
AGTTAAAGTTACTTACACTGTGCAGTATTTCATATATGGGCAAAAGAAATGGCTGAATAAATCAGAATGCAGAAATATCAATAGAACCTA
CTGTGATCTTTCTGCTGAAACTTCTGACTACGAACACCAGTATTATGCCAAAGTTAAGGCCATTTGGGGAACAAAGTGTTCCAAATGGGC
TGAAAGTGGACGGTTCTATCCTTTTTTAGAAACACAAATTGGCCCACCAGAGGTGGCACTGACTACAGATGAGAAGTCCATTTCTGTTGT
CCTGACAGCTCCAGAGAAGTGGAAGAGAAATCCAGAAGACCTTCCTGTTTCCATGCAACAAATATACTCCAATCTGAAGTATAACGTGTC
TGTGTTGAATACTAAATCAAACAGAACGTGGTCCCAGTGTGTGACCAACCACACGCTGGTGCTCACCTGGCTGGAGCCGAACACTCTTTA
CTGCGTACACGTGGAGTCCTTCGTCCCAGGGCCCCCTCGCCGTGCTCAGCCTTCTGAGAAGCAGTGTGCCAGGACTTTGAAAGATCAATC
ATCAGAGTTCAAGGCTAAAATCATCTTCTGGTATGTTTTGCCCGTATCTATTACCGTGTTTCTTTTTTCTGTGATGGGCTATTCCATCTA
CCGATATATCCACGTTGGCAAAGAGAAACACCCAGCAAATTTGATTTTGATTTATGGAAATGAATTTGACAAAAGATTCTTTGTGCCTGC
TGAAAAAATCGTGATTAACTTTATCACCCTCAATATCTCGGATGATTCTAAAATTTCTCATCAGGATATGAGTTTACTGGGAAAAAGCAG
TGATGTATCCAGCCTTAATGATCCTCAGCCCAGCGGGAACCTGAGGCCCCCTCAGGAGGAAGAGGAGGTGAAACATTTAGGGTATGCTTC
GCATTTGATGGAAATTTTTTGTGACTCTGAAGAAAACACGGAAGGTACTTCTCTCACCCAGCAAGAGTCCCTCAGCAGAACAATACCCCC
GGATAAAACAGTCATTGAATATGAATATGATGTCAGAACCACTGACATTTGTGCGGGGCCTGAAGAGCAGGAGCTCAGTTTGCAGGAGGA
GGTGTCCACACAAGGAACATTATTGGAGTCGCAGGCAGCGTTGGCAGTCTTGGGCCCGCAAACGTTACAGTACTCATACACCCCTCAGCT
CCAAGACTTAGACCCCCTGGCGCAGGAGCACACAGACTCGGAGGAGGGGCCGGAGGAAGAGCCATCGACGACCCTGGTCGACTGGGATCC
CCAAACTGGCAGGCTGTGTATTCCTTCGCTGTCCAGCTTCGACCAGGATTCAGAGGGCTGCGAGCCTTCTGAGGGGGATGGGCTCGGAGA
GGAGGGTCTTCTATCTAGACTCTATGAGGAGCCGGCTCCAGACAGGCCACCAGGAGAAAATGAAACCTATCTCATGCAATTCATGGAGGA
ATGGGGGTTATATGTGCAGATGGAAAACTGATGCCAACACTTCCTTTTGCCTTTTGTTTCCTGTGCAAACAAGTGAGTCACCCCTTTGAT
CCCAGCCATAAAGTACCTGGGATGAAAGAAGTTTTTTCCAGTTTGTCAGTGTCTGTGAGAATTACTTATTTCTTTTCTCTATTCTCATAG
CACGTGTGTGATTGGTTCATGCATGTAGGTCTCTTAACAATGATGGTGGGCCTCTGGAGTCCAGGGGCTGGCCGGTTGTTCTATGCAGAG
AAAGCAGTCAATAAATGTTTGCCAGACTGGGTGCAGAATTTATTCAGGTGGGTGTACTCTGGCCTCTTGGTTCATTATTTTCAAACAAGC
ACACTTGTACAATTATTTTCTGGGTACTTCCCATATGCACATAGCACTGTAAAAAATATTTCCCAAAGATCACTCATTTTATAAATACCA
CTTTTTCAGAATTGGGTTTATTGCGAGCAGGAGGAGATACTTAAAACATGCACATATACCAGGTTGGTGGTAAGTTGGTCGCATGTGAAA
ACCTCAACTATTTAATCATCATGATTCATATTTTGAGTGAATACATCAGGCACAGACCTTCATGATATCACACACTCTTGGCTACTTTAA
GAGGCCATCTTTAATACTTTATGAGTAGTTCTGGAGTGTAAACATAAACGAGTATTCTTTTGTAGTCAGAAAAGTGTCCTCTCAATAATT
TAGTAGGGGCTTATTGTCTCTCAAAACTAACCTAAAAGAAAATGACACATTTTATAATAGAATATTACATTTATTTCTGGAAGTGTGTTT
TCAAAAAGATATTTACATAGTCTGTAAACTAGAAAGTGTTAGGTAAAGCTCTAGGTTACTGTGTTACTATTATAATATTAAACATTCGAA
TAGGCAGTCGTTCAAAGACTCTTTGGAATATCTATGAATGAATATCCTCTATTCTTATAATATTAAAACCCATAAGTAAATATAGGACAT
ACAAGAGAAATGAGTTAAATGACTATGTAAGGGAGAGTTTATTAAAATTTGATGAAATTTACTGTAGGAACTAAACTATGCCATAAAACA
ATAGCTTTCTAGTTCATTTCCAGTAACTGTTCCCATCTCCTTTACCACTTGTTAAGAAAATTAAATTCTTCAGTCACGCTGCTTTAAAAT
GGGACAAAATCTATTAAGTTGAACCATATATAATTGTGGATATTTGGCTGTTTTTAATCTGACAAGCAGTAACTTCATATGGTTTGCCTT
AATATATATTTGTTTTAGTCATGAACTCATAATCCATTGATGCTCTTTCATGAGAAGAGATATCACCCATATTTCCTTATTGATATTATT
GGTACAGGCAGACAACCCTGGTAGGAGAGATGGATTCTGGGGTCATGACCTTTCGTGATTATCCGCAAATGCAAACAGTTTCAGATCTAA
TGGTTTAATTTAGGGAGTAATTATATTAATCAGAGTGTTCTGTTATTCTCAATCTTTATAGAAACGATTCTGCTGGTTTTGAAGAACAGA

>In-frame_ENST00000417268_ENST00000316649_TCGA-HB-A3YV_SCAF8_chr6_155114110_+_IL20RA_chr6_137338240_length(amino acids)=755AA_start in transcript=13_stop in transcript=2280
MRGPTRVRHIGCRSRCCQRFLLCLRRAGLVPAARAAGSAPSSRPRSSPRLALPTQCSGRRLFRRRARGLRSDNMEAVKTFNSELYSLNDY
KPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDK
SKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPVPCVSGGLPKPANITFLSINMKNVLQWTPPEGLQGVKVT
YTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQYYAKVKAIWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAP
EKWKRNPEDLPVSMQQIYSNLKYNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHVESFVPGPPRRAQPSEKQCARTLKDQSSEFK
AKIIFWYVLPVSITVFLFSVMGYSIYRYIHVGKEKHPANLILIYGNEFDKRFFVPAEKIVINFITLNISDDSKISHQDMSLLGKSSDVSS
LNDPQPSGNLRPPQEEEEVKHLGYASHLMEIFCDSEENTEGTSLTQQESLSRTIPPDKTVIEYEYDVRTTDICAGPEEQELSLQEEVSTQ
GTLLESQAALAVLGPQTLQYSYTPQLQDLDPLAQEHTDSEEGPEEEPSTTLVDWDPQTGRLCIPSLSSFDQDSEGCEPSEGDGLGEEGLL

--------------------------------------------------------------
>In-frame_ENST00000367186_ENST00000316649_TCGA-HB-A3YV_SCAF8_chr6_155114110_+_IL20RA_chr6_137338240_length(transcript)=3841nt_BP=680nt
ATATTGGATGCCGCAGCCGCTGCTGCCAGCGCTTCCTCCTCTGTCTTCGCCGAGCGGGGCTGGTTCCTGCGGCCCGAGCGGCGGGGAGTG
CAGTGGCCGCCGCCTCTTCCGCCGCCGGGCTCGGGGCCTCCGCAGCGACAACATGGAGGCCGTGAAGACCTTCAATAGCGAGGATTGTGC
CTCTACTCCTGCTTGTACAGACTGCTTTTCCAGCAGCATGGACACAAGAAGCATATTGTATTCCCTGAATGACTATAAACCACCCATTTC
GAAAGCGAAAATGACCCAAATTACTAAGGCAGCCATCAAAGCTATTAAGTTCTATAAACATGTGGTACAGAGTGTTGAGAAGTTTATTCA
GAAATGTAAACCAGAATACAAAGTACCTGGACTTTATGTTATTGACTCCATTGTGCGACAATCCCGACATCAGTTTGGTCAAGAAAAGGA
TGTGTTTGCACCCAGATTTAGTAATAACATCATTAGCACTTTCCAGAATTTATATCGTTGCCCTGGGGATGACAAGAGTAAAATAGTGAG
AGTACTAAACTTATGGCAGAAGAATAATGTATTTAAGAGTGAGATTATTCAGCCCCTTTTGGATATGGCAGCCGGGATTCCGCCTCCAGT
TGTCACACCTGTTTTGGCCAGCACTACCACTGCTATGAGCAATACTCCAGTTCCCTGTGTCTCTGGTGGTTTGCCTAAACCTGCAAACAT
CACCTTCTTATCCATCAACATGAAGAATGTCCTACAATGGACTCCACCAGAGGGTCTTCAAGGAGTTAAAGTTACTTACACTGTGCAGTA
TTTCATATATGGGCAAAAGAAATGGCTGAATAAATCAGAATGCAGAAATATCAATAGAACCTACTGTGATCTTTCTGCTGAAACTTCTGA
CTACGAACACCAGTATTATGCCAAAGTTAAGGCCATTTGGGGAACAAAGTGTTCCAAATGGGCTGAAAGTGGACGGTTCTATCCTTTTTT
AGAAACACAAATTGGCCCACCAGAGGTGGCACTGACTACAGATGAGAAGTCCATTTCTGTTGTCCTGACAGCTCCAGAGAAGTGGAAGAG
AAATCCAGAAGACCTTCCTGTTTCCATGCAACAAATATACTCCAATCTGAAGTATAACGTGTCTGTGTTGAATACTAAATCAAACAGAAC
GTGGTCCCAGTGTGTGACCAACCACACGCTGGTGCTCACCTGGCTGGAGCCGAACACTCTTTACTGCGTACACGTGGAGTCCTTCGTCCC
AGGGCCCCCTCGCCGTGCTCAGCCTTCTGAGAAGCAGTGTGCCAGGACTTTGAAAGATCAATCATCAGAGTTCAAGGCTAAAATCATCTT
CTGGTATGTTTTGCCCGTATCTATTACCGTGTTTCTTTTTTCTGTGATGGGCTATTCCATCTACCGATATATCCACGTTGGCAAAGAGAA
ACACCCAGCAAATTTGATTTTGATTTATGGAAATGAATTTGACAAAAGATTCTTTGTGCCTGCTGAAAAAATCGTGATTAACTTTATCAC
CCTCAATATCTCGGATGATTCTAAAATTTCTCATCAGGATATGAGTTTACTGGGAAAAAGCAGTGATGTATCCAGCCTTAATGATCCTCA
GCCCAGCGGGAACCTGAGGCCCCCTCAGGAGGAAGAGGAGGTGAAACATTTAGGGTATGCTTCGCATTTGATGGAAATTTTTTGTGACTC
TGAAGAAAACACGGAAGGTACTTCTCTCACCCAGCAAGAGTCCCTCAGCAGAACAATACCCCCGGATAAAACAGTCATTGAATATGAATA
TGATGTCAGAACCACTGACATTTGTGCGGGGCCTGAAGAGCAGGAGCTCAGTTTGCAGGAGGAGGTGTCCACACAAGGAACATTATTGGA
GTCGCAGGCAGCGTTGGCAGTCTTGGGCCCGCAAACGTTACAGTACTCATACACCCCTCAGCTCCAAGACTTAGACCCCCTGGCGCAGGA
GCACACAGACTCGGAGGAGGGGCCGGAGGAAGAGCCATCGACGACCCTGGTCGACTGGGATCCCCAAACTGGCAGGCTGTGTATTCCTTC
GCTGTCCAGCTTCGACCAGGATTCAGAGGGCTGCGAGCCTTCTGAGGGGGATGGGCTCGGAGAGGAGGGTCTTCTATCTAGACTCTATGA
GGAGCCGGCTCCAGACAGGCCACCAGGAGAAAATGAAACCTATCTCATGCAATTCATGGAGGAATGGGGGTTATATGTGCAGATGGAAAA
CTGATGCCAACACTTCCTTTTGCCTTTTGTTTCCTGTGCAAACAAGTGAGTCACCCCTTTGATCCCAGCCATAAAGTACCTGGGATGAAA
GAAGTTTTTTCCAGTTTGTCAGTGTCTGTGAGAATTACTTATTTCTTTTCTCTATTCTCATAGCACGTGTGTGATTGGTTCATGCATGTA
GGTCTCTTAACAATGATGGTGGGCCTCTGGAGTCCAGGGGCTGGCCGGTTGTTCTATGCAGAGAAAGCAGTCAATAAATGTTTGCCAGAC
TGGGTGCAGAATTTATTCAGGTGGGTGTACTCTGGCCTCTTGGTTCATTATTTTCAAACAAGCACACTTGTACAATTATTTTCTGGGTAC
TTCCCATATGCACATAGCACTGTAAAAAATATTTCCCAAAGATCACTCATTTTATAAATACCACTTTTTCAGAATTGGGTTTATTGCGAG
CAGGAGGAGATACTTAAAACATGCACATATACCAGGTTGGTGGTAAGTTGGTCGCATGTGAAAACCTCAACTATTTAATCATCATGATTC
ATATTTTGAGTGAATACATCAGGCACAGACCTTCATGATATCACACACTCTTGGCTACTTTAAGAGGCCATCTTTAATACTTTATGAGTA
GTTCTGGAGTGTAAACATAAACGAGTATTCTTTTGTAGTCAGAAAAGTGTCCTCTCAATAATTTAGTAGGGGCTTATTGTCTCTCAAAAC
TAACCTAAAAGAAAATGACACATTTTATAATAGAATATTACATTTATTTCTGGAAGTGTGTTTTCAAAAAGATATTTACATAGTCTGTAA
ACTAGAAAGTGTTAGGTAAAGCTCTAGGTTACTGTGTTACTATTATAATATTAAACATTCGAATAGGCAGTCGTTCAAAGACTCTTTGGA
ATATCTATGAATGAATATCCTCTATTCTTATAATATTAAAACCCATAAGTAAATATAGGACATACAAGAGAAATGAGTTAAATGACTATG
TAAGGGAGAGTTTATTAAAATTTGATGAAATTTACTGTAGGAACTAAACTATGCCATAAAACAATAGCTTTCTAGTTCATTTCCAGTAAC
TGTTCCCATCTCCTTTACCACTTGTTAAGAAAATTAAATTCTTCAGTCACGCTGCTTTAAAATGGGACAAAATCTATTAAGTTGAACCAT
ATATAATTGTGGATATTTGGCTGTTTTTAATCTGACAAGCAGTAACTTCATATGGTTTGCCTTAATATATATTTGTTTTAGTCATGAACT
CATAATCCATTGATGCTCTTTCATGAGAAGAGATATCACCCATATTTCCTTATTGATATTATTGGTACAGGCAGACAACCCTGGTAGGAG
AGATGGATTCTGGGGTCATGACCTTTCGTGATTATCCGCAAATGCAAACAGTTTCAGATCTAATGGTTTAATTTAGGGAGTAATTATATT
AATCAGAGTGTTCTGTTATTCTCAATCTTTATAGAAACGATTCTGCTGGTTTTGAAGAACAGATGTATTACACTAACTGTAAAAGTAGTT

>In-frame_ENST00000367186_ENST00000316649_TCGA-HB-A3YV_SCAF8_chr6_155114110_+_IL20RA_chr6_137338240_length(amino acids)=748AA_start in transcript=7_stop in transcript=2253
MPQPLLPALPPLSSPSGAGSCGPSGGECSGRRLFRRRARGLRSDNMEAVKTFNSEDCASTPACTDCFSSSMDTRSILYSLNDYKPPISKA
KMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVL
NLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPVPCVSGGLPKPANITFLSINMKNVLQWTPPEGLQGVKVTYTVQYFI
YGQKKWLNKSECRNINRTYCDLSAETSDYEHQYYAKVKAIWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNP
EDLPVSMQQIYSNLKYNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHVESFVPGPPRRAQPSEKQCARTLKDQSSEFKAKIIFWY
VLPVSITVFLFSVMGYSIYRYIHVGKEKHPANLILIYGNEFDKRFFVPAEKIVINFITLNISDDSKISHQDMSLLGKSSDVSSLNDPQPS
GNLRPPQEEEEVKHLGYASHLMEIFCDSEENTEGTSLTQQESLSRTIPPDKTVIEYEYDVRTTDICAGPEEQELSLQEEVSTQGTLLESQ
AALAVLGPQTLQYSYTPQLQDLDPLAQEHTDSEEGPEEEPSTTLVDWDPQTGRLCIPSLSSFDQDSEGCEPSEGDGLGEEGLLSRLYEEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SCAF8-IL20RA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCAF8-IL20RA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCAF8-IL20RA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL20RAC0000786Spontaneous abortion1CTD_human
TgeneIL20RAC0000822Abortion, Tubal1CTD_human
TgeneIL20RAC3830362Early Pregnancy Loss1CTD_human
TgeneIL20RAC4552766Miscarriage1CTD_human