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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SCMH1-CASP9 (FusionGDB2 ID:79157)

Fusion Gene Summary for SCMH1-CASP9

Fusion gene summary

Fusion gene information	Fusion gene name: SCMH1-CASP9
	Fusion gene ID: 79157
		Hgene	Tgene
	Gene symbol	SCMH1	CASP9
	Gene ID	22955	842
	Gene name	Scm polycomb group protein homolog 1	caspase 9
	Synonyms	Scml3	APAF-3\|APAF3\|ICE-LAP6\|MCH6\|PPP1R56
	Cytomap	1p34.2	1p36.21
	Type of gene	protein-coding	protein-coding
	Description	polycomb protein SCMH1sex comb on midleg homolog 1	caspase-9ICE-like apoptotic protease 6apoptotic protease MCH-6apoptotic protease activating factor 3caspase 9, apoptosis-related cysteine peptidaseprotein phosphatase 1, regulatory subunit 56
	Modification date	20200313	20200322
	UniProtAcc	.	P55211
	Ensembl transtripts involved in fusion gene	ENST00000456518, ENST00000397174, ENST00000402904, ENST00000361191, ENST00000397171, ENST00000361705, ENST00000326197, ENST00000372595, ENST00000337495, ENST00000372596, ENST00000372597, ENST00000472037,	ENST00000546424, ENST00000333868, ENST00000348549, ENST00000375890, ENST00000469637,
Fusion gene scores	* DoF score	18 X 14 X 11=2772	1 X 1 X 1=1
	# samples	24	2
	** MAII score	log2(24/2772*10)=-3.52982094652869 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/1*10)=4.32192809488736
Context	PubMed: SCMH1 [Title/Abstract] AND CASP9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SCMH1(41707731)-CASP9(15844890), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CASP9	GO:0006974	cellular response to DNA damage stimulus	15657060
Tgene	CASP9	GO:0034644	cellular response to UV	15657060
Tgene	CASP9	GO:0042770	signal transduction in response to DNA damage	15657060

Fusion gene breakpoints across SCMH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CASP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-K1-A3PO-01A	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
ChimerDB4	SARC	TCGA-K1-A3PO	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
ChimerDB4	SARC	TCGA-K1-A3PO-01A	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
ChimerDB4	SARC	TCGA-K1-A3PO-01A	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-

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Fusion Gene ORF analysis for SCMH1-CASP9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000456518	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000456518	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000456518	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000456518	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000456518	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397174	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397174	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397174	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397174	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397174	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000402904	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000402904	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000402904	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000402904	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000402904	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361191	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361191	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361191	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361191	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361191	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397171	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397171	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397171	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397171	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397171	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361705	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361705	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361705	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361705	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361705	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000326197	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000326197	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000326197	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000326197	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000326197	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000372595	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000372595	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000372595	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000372595	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000372595	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000337495	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000337495	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000337495	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000337495	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000337495	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372596	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372596	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372596	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372596	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372596	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372597	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372597	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372597	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372597	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372597	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000472037	ENST00000546424	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000472037	ENST00000333868	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000472037	ENST00000348549	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000472037	ENST00000375890	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000472037	ENST00000469637	SCMH1	chr1	41707731	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000456518	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000456518	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000456518	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000456518	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000456518	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397174	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397174	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397174	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397174	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397174	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000402904	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000402904	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000402904	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000402904	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000402904	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361191	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361191	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361191	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361191	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361191	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397171	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397171	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000397171	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397171	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000397171	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361705	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361705	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000361705	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361705	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000361705	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000326197	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000326197	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000326197	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000326197	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000326197	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000372595	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000372595	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000372595	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000372595	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000372595	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000337495	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000337495	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000337495	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000337495	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000337495	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372596	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372596	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372596	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372596	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372596	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372597	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372597	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-3CDS	ENST00000372597	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372597	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
5UTR-5UTR	ENST00000372597	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000472037	ENST00000546424	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000472037	ENST00000333868	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-3CDS	ENST00000472037	ENST00000348549	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000472037	ENST00000375890	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-
intron-5UTR	ENST00000472037	ENST00000469637	SCMH1	chr1	41707730	-	CASP9	chr1	15844890	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for SCMH1-CASP9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCMH1-CASP9

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CASP9 P55211
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; FUNCTION: Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for SCMH1-CASP9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SCMH1-CASP9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SCMH1-CASP9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	CASP9	P55211	DB00282	Pamidronic acid	Cleavage	Small molecule	Approved
Tgene	CASP9	P55211	DB00282	Pamidronic acid	Cleavage	Small molecule	Approved

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Related Diseases for SCMH1-CASP9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SCMH1	C0004238	Atrial Fibrillation	2	CTD_human
Hgene	SCMH1	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Hgene	SCMH1	C2585653	Persistent atrial fibrillation	2	CTD_human
Hgene	SCMH1	C3468561	familial atrial fibrillation	2	CTD_human
Tgene	CASP9	C0007786	Brain Ischemia	1	CTD_human
Tgene	CASP9	C0007787	Transient Ischemic Attack	1	CTD_human
Tgene	CASP9	C0013604	Edema	1	CTD_human
Tgene	CASP9	C0027055	Myocardial Reperfusion Injury	1	CTD_human
Tgene	CASP9	C0027765	nervous system disorder	1	CTD_human
Tgene	CASP9	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	CASP9	C0035305	Retinal Detachment	1	CTD_human
Tgene	CASP9	C0151603	Anasarca	1	CTD_human
Tgene	CASP9	C0339546	Retinal Pigment Epithelial Detachment	1	CTD_human
Tgene	CASP9	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	CASP9	C0472381	Posterior Circulation Transient Ischemic Attack	1	CTD_human
Tgene	CASP9	C0751019	Carotid Circulation Transient Ischemic Attack	1	CTD_human
Tgene	CASP9	C0751020	Transient Ischemic Attack, Vertebrobasilar Circulation	1	CTD_human
Tgene	CASP9	C0751021	Crescendo Transient Ischemic Attacks	1	CTD_human
Tgene	CASP9	C0751022	Brain Stem Ischemia, Transient	1	CTD_human
Tgene	CASP9	C0917798	Cerebral Ischemia	1	CTD_human
Tgene	CASP9	C0917805	Transient Cerebral Ischemia	1	CTD_human
Tgene	CASP9	C1527335	Transient Ischemic Attack, Anterior Circulation	1	CTD_human
Tgene	CASP9	C4721453	Peripheral Nervous System Diseases	1	CTD_human