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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SCMH1-EIF2B3 (FusionGDB2 ID:79159)

Fusion Gene Summary for SCMH1-EIF2B3

check button Fusion gene summary
Fusion gene informationFusion gene name: SCMH1-EIF2B3
Fusion gene ID: 79159
HgeneTgene
Gene symbol

SCMH1

EIF2B3

Gene ID

22955

8891

Gene nameScm polycomb group protein homolog 1eukaryotic translation initiation factor 2B subunit gamma
SynonymsScml3EIF-2B|EIF2Bgamma
Cytomap

1p34.2

1p34.1

Type of geneprotein-codingprotein-coding
Descriptionpolycomb protein SCMH1sex comb on midleg homolog 1translation initiation factor eIF-2B subunit gammaeIF-2B GDP-GTP exchange factor subunit gammaeukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
Modification date2020031320200313
UniProtAcc.

Q9NR50

Ensembl transtripts involved in fusion geneENST00000456518, ENST00000397174, 
ENST00000402904, ENST00000361191, 
ENST00000397171, ENST00000361705, 
ENST00000326197, ENST00000372595, 
ENST00000337495, ENST00000372596, 
ENST00000372597, ENST00000472037, 
ENST00000360403, ENST00000372183, 
ENST00000480675, 
Fusion gene scores* DoF score18 X 14 X 11=277211 X 6 X 9=594
# samples 2413
** MAII scorelog2(24/2772*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCMH1 [Title/Abstract] AND EIF2B3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCMH1(41578955)-EIF2B3(45316675), # samples:3
EIF2B3(45392300)-SCMH1(41514562), # samples:1
Anticipated loss of major functional domain due to fusion event.EIF2B3-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF2B3-SCMH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF2B3-SCMH1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
EIF2B3-SCMH1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SCMH1-EIF2B3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SCMH1-EIF2B3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SCMH1-EIF2B3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SCMH1-EIF2B3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF2B3

GO:0006413

translational initiation

10900014|16289705

TgeneEIF2B3

GO:0050852

T cell receptor signaling pathway

8626696


check buttonFusion gene breakpoints across SCMH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF2B3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-JL-A3YW-01ASCMH1chr1

41578955

-EIF2B3chr1

45316675

-
ChimerDB4BRCATCGA-JL-A3YW-01ASCMH1chr1

41578955

-EIF2B3chr1

45316675

-
ChimerDB4BRCATCGA-JL-A3YW-01ASCMH1chr1

41578955

-EIF2B3chr1

45316675

-


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Fusion Gene ORF analysis for SCMH1-EIF2B3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000456518ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
intron-intronENST00000456518ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
intron-intronENST00000456518ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
In-frameENST00000397174ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000397174ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000397174ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
In-frameENST00000402904ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000402904ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000402904ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
Frame-shiftENST00000361191ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000361191ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000361191ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
In-frameENST00000397171ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000397171ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000397171ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
Frame-shiftENST00000361705ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000361705ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000361705ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
In-frameENST00000326197ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000326197ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000326197ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
Frame-shiftENST00000372595ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000372595ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000372595ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
Frame-shiftENST00000337495ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000337495ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000337495ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
In-frameENST00000372596ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000372596ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000372596ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
Frame-shiftENST00000372597ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000372597ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
5CDS-intronENST00000372597ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
intron-3CDSENST00000472037ENST00000360403SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
intron-intronENST00000472037ENST00000372183SCMH1chr1

41578955

-EIF2B3chr1

45316675

-
intron-intronENST00000472037ENST00000480675SCMH1chr1

41578955

-EIF2B3chr1

45316675

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397174SCMH1chr141578955-ENST00000360403EIF2B3chr145316675-131010843151136273
ENST00000402904SCMH1chr141578955-ENST00000360403EIF2B3chr145316675-131010843151136273
ENST00000397171SCMH1chr141578955-ENST00000360403EIF2B3chr145316675-12169904581042194
ENST00000326197SCMH1chr141578955-ENST00000360403EIF2B3chr145316675-124110152461067273
ENST00000372596SCMH1chr141578955-ENST00000360403EIF2B3chr145316675-135511295971181194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397174ENST00000360403SCMH1chr141578955-EIF2B3chr145316675-0.0104647890.9895353
ENST00000402904ENST00000360403SCMH1chr141578955-EIF2B3chr145316675-0.0104647890.9895353
ENST00000397171ENST00000360403SCMH1chr141578955-EIF2B3chr145316675-0.0055951230.9944049
ENST00000326197ENST00000360403SCMH1chr141578955-EIF2B3chr145316675-0.0120357870.9879643
ENST00000372596ENST00000360403SCMH1chr141578955-EIF2B3chr145316675-0.0056880560.9943119

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Fusion Genomic Features for SCMH1-EIF2B3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SCMH1-EIF2B3


check button Go to

FGviewer for the breakpoints of chr1:41578955-chr1:45316675

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF2B3

Q9NR50

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCMH1chr1:41578955chr1:45316675ENST00000326197-715134_235238.33333333333334661.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000326197-71528_126238.33333333333334661.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000337495-815134_235248.33333333333334649.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000337495-81528_126248.33333333333334649.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000361191-51228_126177.33333333333334578.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000361705-61328_126191.33333333333334592.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372595-71528_126177.33333333333334600.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372596-91628_126177.33333333333334578.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372597-81528_126191.33333333333334592.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000397171-71428_126177.33333333333334578.0RepeatNote=MBT 1
HgeneSCMH1chr1:41578955chr1:45316675ENST00000402904-816134_235238.33333333333334661.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000402904-81628_126238.33333333333334661.0RepeatNote=MBT 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCMH1chr1:41578955chr1:45316675ENST00000326197-715593_658238.33333333333334661.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000337495-815593_658248.33333333333334649.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000361191-512593_658177.33333333333334578.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000361705-613593_658191.33333333333334592.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372595-715593_658177.33333333333334600.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372596-916593_658177.33333333333334578.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372597-815593_658191.33333333333334592.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000397171-714593_658177.33333333333334578.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000402904-816593_658238.33333333333334661.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000456518-19593_6580481.0DomainSAM
HgeneSCMH1chr1:41578955chr1:45316675ENST00000361191-512134_235177.33333333333334578.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000361705-613134_235191.33333333333334592.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372595-715134_235177.33333333333334600.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372596-916134_235177.33333333333334578.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000372597-815134_235191.33333333333334592.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000397171-714134_235177.33333333333334578.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000456518-19134_2350481.0RepeatNote=MBT 2
HgeneSCMH1chr1:41578955chr1:45316675ENST00000456518-1928_1260481.0RepeatNote=MBT 1


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Fusion Gene Sequence for SCMH1-EIF2B3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000397174_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(transcript)=1310nt_BP=1084nt
TGATAGACTGGAGTGATGTTAGAAAACACAAATATGGTCACCTATCAGAGTCTGCATCCCAATATCAAGAAGCTGCTGACATCCTGGATC
TAGGGTTGTAAAGAAGATTACATGAGCTAATGGATGTGAAAACATCTTAAAAACTCTCAAATACTTTTCAACTTTGGAGGATTATTATGA
TTTTCATTCTGTTCAGCGGCTATACTCAGACTTTACTCTAAAAGTCAAATCTTCTGACATTCTTTGAAGTGAAGCATTCTATGAATGTGA
GCTGAAGAAATGAATGAAATGAAATAATGCAGCATCTAGTGCTTTTTGCATGGCCCAAAGGGGCTCTGTGCTGCTCCACTACAGAGGAAA
CTTCAAGAAATGCTGGTTTGCTACAGTGTTTTAGCTTGTGAGATTCTCTGGGACCTTCCCTGCTCCATCATGGGGTCACCTCTAGGTCAT
TTTACCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCGCCTGTCCATTGCTTCAAGCAGTCCTACACACCTCCAAGCAACGAG
TTCAAGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACCACATCCACCTGTATTGCCACAGTAGTTGGACTGACAGGTGCCCGC
CTTCGCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGGCGGCTGGTTGACTCAGCTGAAATCCAGCCTATTGGGAACTGTGAA
AAGAATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAATGCGTCTTCTTGGCCCATGTTCCTTTTGAAGACGCTAAATGGAGCA
GAGATGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCTTCCCACAACTTCTTCAAAATGGGAATGAAGCTAGAAGCTGTGGAC
AGGAAGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTTCGGGGCTCAGAGGTGCTTGTCACTTTTGATGGGTGGCGAGGGGCC
TTTGACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTGGGCTGGTGTTCCTTGACTGGAGACAACCTGCAGCCTCCTGGCACC
AAAGCTAAACGAGTGAATGAGGTGATCGTGGGGAATGACCAGCTCATGGAGATCTGAGTTCTGAGCAAGTCAGACTCCTTCCTTTTGGCC
TCCAAAGCCACAGATGTTGGCCGGCCCACCTGTTTAACTCTGTATTTATTTCCCAATAAAGAAGGGCTTCCAAAGGCATGCTGGAGACTT

>In-frame_ENST00000397174_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(amino acids)=273AA_start in transcript=315_stop in transcript=1136
MHGPKGLCAAPLQRKLQEMLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNT
TSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSP
SHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKAKRVNEVIVGNDQL

--------------------------------------------------------------
>In-frame_ENST00000402904_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(transcript)=1310nt_BP=1084nt
TGATAGACTGGAGTGATGTTAGAAAACACAAATATGGTCACCTATCAGAGTCTGCATCCCAATATCAAGAAGCTGCTGACATCCTGGATC
TAGGGTTGTAAAGAAGATTACATGAGCTAATGGATGTGAAAACATCTTAAAAACTCTCAAATACTTTTCAACTTTGGAGGATTATTATGA
TTTTCATTCTGTTCAGCGGCTATACTCAGACTTTACTCTAAAAGTCAAATCTTCTGACATTCTTTGAAGTGAAGCATTCTATGAATGTGA
GCTGAAGAAATGAATGAAATGAAATAATGCAGCATCTAGTGCTTTTTGCATGGCCCAAAGGGGCTCTGTGCTGCTCCACTACAGAGGAAA
CTTCAAGAAATGCTGGTTTGCTACAGTGTTTTAGCTTGTGAGATTCTCTGGGACCTTCCCTGCTCCATCATGGGGTCACCTCTAGGTCAT
TTTACCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCGCCTGTCCATTGCTTCAAGCAGTCCTACACACCTCCAAGCAACGAG
TTCAAGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACCACATCCACCTGTATTGCCACAGTAGTTGGACTGACAGGTGCCCGC
CTTCGCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGGCGGCTGGTTGACTCAGCTGAAATCCAGCCTATTGGGAACTGTGAA
AAGAATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAATGCGTCTTCTTGGCCCATGTTCCTTTTGAAGACGCTAAATGGAGCA
GAGATGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCTTCCCACAACTTCTTCAAAATGGGAATGAAGCTAGAAGCTGTGGAC
AGGAAGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTTCGGGGCTCAGAGGTGCTTGTCACTTTTGATGGGTGGCGAGGGGCC
TTTGACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTGGGCTGGTGTTCCTTGACTGGAGACAACCTGCAGCCTCCTGGCACC
AAAGCTAAACGAGTGAATGAGGTGATCGTGGGGAATGACCAGCTCATGGAGATCTGAGTTCTGAGCAAGTCAGACTCCTTCCTTTTGGCC
TCCAAAGCCACAGATGTTGGCCGGCCCACCTGTTTAACTCTGTATTTATTTCCCAATAAAGAAGGGCTTCCAAAGGCATGCTGGAGACTT

>In-frame_ENST00000402904_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(amino acids)=273AA_start in transcript=315_stop in transcript=1136
MHGPKGLCAAPLQRKLQEMLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNT
TSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSP
SHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKAKRVNEVIVGNDQL

--------------------------------------------------------------
>In-frame_ENST00000397171_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(transcript)=1216nt_BP=990nt
TTAATCTTATACTTTCTTTCCACATGACTATTTTTCTCTCCCTCTGCAGTGATAGACTGGAGTGATGTTAGAAAACACAAATATGGTCAC
CTATCAGAGTCTGCATCCCAATATCAAGAAGCTGCTGACATCCTGGATCTAGGGTTGTAAAGAAGATTACATGAGCTAATGGATGTGAAA
ACATCTTAAAAACTCTCAAATACTTTTCAACTTTGGAGGATTATTATGATTTTCATTCTGTTCAGCGGCTATACTCAGACTTTACTCTAA
AAGTCAAATCTTCTGACATTCTTTGAAGTGAAGCATTCTATGAATGTGAGCTGAAGAAATGAATGAAATGAAATAATGCAGGTCATTTTA
CCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCGCCTGTCCATTGCTTCAAGCAGTCCTACACACCTCCAAGCAACGAGTTCA
AGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACCACATCCACCTGTATTGCCACAGTAGTTGGACTGACAGGTGCCCGCCTTC
GCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGGCGGCTGGTTGACTCAGCTGAAATCCAGCCTATTGGGAACTGTGAAAAGA
ATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAATGCGTCTTCTTGGCCCATGTTCCTTTTGAAGACGCTAAATGGAGCAGAGA
TGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCTTCCCACAACTTCTTCAAAATGGGAATGAAGCTAGAAGCTGTGGACAGGA
AGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTTCGGGGCTCAGAGGTGCTTGTCACTTTTGATGGGTGGCGAGGGGCCTTTG
ACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTGGGCTGGTGTTCCTTGACTGGAGACAACCTGCAGCCTCCTGGCACCAAAG
CTAAACGAGTGAATGAGGTGATCGTGGGGAATGACCAGCTCATGGAGATCTGAGTTCTGAGCAAGTCAGACTCCTTCCTTTTGGCCTCCA
AAGCCACAGATGTTGGCCGGCCCACCTGTTTAACTCTGTATTTATTTCCCAATAAAGAAGGGCTTCCAAAGGCATGCTGGAGACTTGTGG

>In-frame_ENST00000397171_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(amino acids)=194AA_start in transcript=458_stop in transcript=1042
MKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAP
IRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKAKR

--------------------------------------------------------------
>In-frame_ENST00000326197_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(transcript)=1241nt_BP=1015nt
AAGCTGCTGACATCCTGGATCTAGGGTTGTAAAGAAGATTACATGAGCTAATGGATGTGAAAACATCTTAAAAACTCTCAAATACTTTTC
AACTTTGGAGGATTATTATGATTTTCATTCTGTTCAGCGGCTATACTCAGACTTTACTCTAAAAGTCAAATCTTCTGACATTCTTTGAAG
TGAAGCATTCTATGAATGTGAGCTGAAGAAATGAATGAAATGAAATAATGCAGCATCTAGTGCTTTTTGCATGGCCCAAAGGGGCTCTGT
GCTGCTCCACTACAGAGGAAACTTCAAGAAATGCTGGTTTGCTACAGTGTTTTAGCTTGTGAGATTCTCTGGGACCTTCCCTGCTCCATC
ATGGGGTCACCTCTAGGTCATTTTACCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCGCCTGTCCATTGCTTCAAGCAGTCC
TACACACCTCCAAGCAACGAGTTCAAGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACCACATCCACCTGTATTGCCACAGTA
GTTGGACTGACAGGTGCCCGCCTTCGCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGGCGGCTGGTTGACTCAGCTGAAATC
CAGCCTATTGGGAACTGTGAAAAGAATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAATGCGTCTTCTTGGCCCATGTTCCTT
TTGAAGACGCTAAATGGAGCAGAGATGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCTTCCCACAACTTCTTCAAAATGGGA
ATGAAGCTAGAAGCTGTGGACAGGAAGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTTCGGGGCTCAGAGGTGCTTGTCACT
TTTGATGGGTGGCGAGGGGCCTTTGACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTGGGCTGGTGTTCCTTGACTGGAGAC
AACCTGCAGCCTCCTGGCACCAAAGCTAAACGAGTGAATGAGGTGATCGTGGGGAATGACCAGCTCATGGAGATCTGAGTTCTGAGCAAG
TCAGACTCCTTCCTTTTGGCCTCCAAAGCCACAGATGTTGGCCGGCCCACCTGTTTAACTCTGTATTTATTTCCCAATAAAGAAGGGCTT

>In-frame_ENST00000326197_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(amino acids)=273AA_start in transcript=246_stop in transcript=1067
MHGPKGLCAAPLQRKLQEMLVCYSVLACEILWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNT
TSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSP
SHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKAKRVNEVIVGNDQL

--------------------------------------------------------------
>In-frame_ENST00000372596_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(transcript)=1355nt_BP=1129nt
GCGGAAACATGGCGGCGGGAAGAGAGTGAGCCGCCCCGCGCCCCCGCCGCGCCCTCAGATGGAGAAATTAGCATACAAAGAAACTGACTT
GTCAGAAGTCAGAGCAAGGTATTGGTGGATCCAGGGATAAATCCCAAACTTCTTAACCCCTAGACCGGTTTTTAGTCCATTGACTATGCA
GCCTAATGTGATAGACTGGAGTGATGTTAGAAAACACAAATATGGTCACCTATCAGAGTCTGCATCCCAATATCAAGAAGCTGCTGACAT
CCTGGATCTAGGGTTGTAAAGAAGATTACATGAGCTAATGGATGTGAAAACATCTTAAAAACTCTCAAATACTTTTCAACTTTGGAGGAT
TATTATGATTTTCATTCTGTTCAGCGGCTATACTCAGACTTTACTCTAAAAGTCAAATCTTCTGACATTCTTTGAAGTGAAGCATTCTAT
GAATGTGAGCTGAAGAAATGAATGAAATGAAATAATGCAGGTCATTTTACCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCG
CCTGTCCATTGCTTCAAGCAGTCCTACACACCTCCAAGCAACGAGTTCAAGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACC
ACATCCACCTGTATTGCCACAGTAGTTGGACTGACAGGTGCCCGCCTTCGCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGG
CGGCTGGTTGACTCAGCTGAAATCCAGCCTATTGGGAACTGTGAAAAGAATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAAT
GCGTCTTCTTGGCCCATGTTCCTTTTGAAGACGCTAAATGGAGCAGAGATGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCT
TCCCACAACTTCTTCAAAATGGGAATGAAGCTAGAAGCTGTGGACAGGAAGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTT
CGGGGCTCAGAGGTGCTTGTCACTTTTGATGGGTGGCGAGGGGCCTTTGACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTG
GGCTGGTGTTCCTTGACTGGAGACAACCTGCAGCCTCCTGGCACCAAAGCTAAACGAGTGAATGAGGTGATCGTGGGGAATGACCAGCTC
ATGGAGATCTGAGTTCTGAGCAAGTCAGACTCCTTCCTTTTGGCCTCCAAAGCCACAGATGTTGGCCGGCCCACCTGTTTAACTCTGTAT
TTATTTCCCAATAAAGAAGGGCTTCCAAAGGCATGCTGGAGACTTGTGGAGCAGTCCAAAGCTCCATGTCAGGTGGGCTCCAGGTGTACA

>In-frame_ENST00000372596_ENST00000360403_TCGA-JL-A3YW-01A_SCMH1_chr1_41578955_-_EIF2B3_chr1_45316675_length(amino acids)=194AA_start in transcript=597_stop in transcript=1181
MKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAP
IRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKAKR

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Fusion Gene PPI Analysis for SCMH1-EIF2B3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SCMH1-EIF2B3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SCMH1-EIF2B3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSCMH1C0004238Atrial Fibrillation2CTD_human
HgeneSCMH1C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneSCMH1C2585653Persistent atrial fibrillation2CTD_human
HgeneSCMH1C3468561familial atrial fibrillation2CTD_human
TgeneEIF2B3C1858991Childhood Ataxia with Central Nervous System Hypomyelinization6GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneEIF2B3C1847967OVARIOLEUKODYSTROPHY1CTD_human;ORPHANET