FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SCYL1-TRPM8 (FusionGDB2 ID:79285)

Fusion Gene Summary for SCYL1-TRPM8

check button Fusion gene summary
Fusion gene informationFusion gene name: SCYL1-TRPM8
Fusion gene ID: 79285
HgeneTgene
Gene symbol

SCYL1

TRPM8

Gene ID

57410

79054

Gene nameSCY1 like pseudokinase 1transient receptor potential cation channel subfamily M member 8
SynonymsGKLP|HT019|NKTL|NTKL|P105|SCAR21|TAPK|TEIF|TRAPLTRPC6|LTrpC-6|TRPP8|trp-p8
Cytomap

11q13.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionN-terminal kinase-like proteinSCY1-like protein 1SCY1-like, kinase-like 1coated vesicle-associated kinase of 90 kDalikely ortholog of mouse N-terminal kinase-like proteintelomerase regulation-associated proteintelomerase transcriptional elements-inttransient receptor potential cation channel subfamily M member 8TRPM8 cationic channeltransient receptor potential p8transient receptor potential subfamily M member 8
Modification date2020031320200313
UniProtAcc.

TCAF1

Ensembl transtripts involved in fusion geneENST00000525364, ENST00000270176, 
ENST00000420247, ENST00000533862, 
ENST00000279270, ENST00000524944, 
ENST00000527009, ENST00000534462, 
ENST00000324695, ENST00000433712, 
ENST00000355722, ENST00000409625, 
ENST00000466594, 
Fusion gene scores* DoF score8 X 8 X 7=4487 X 7 X 4=196
# samples 147
** MAII scorelog2(14/448*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCYL1 [Title/Abstract] AND TRPM8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSCYL1(65306175)-TRPM8(234826043), # samples:1
Anticipated loss of major functional domain due to fusion event.SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SCYL1-TRPM8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCYL1

GO:0006890

retrograde vesicle-mediated transport, Golgi to ER

18556652


check buttonFusion gene breakpoints across SCYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRPM8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7327-01ASCYL1chr11

65306175

-TRPM8chr2

234826043

+


Top

Fusion Gene ORF analysis for SCYL1-TRPM8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000525364ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000525364ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000525364ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000525364ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000525364ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000270176ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000270176ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000270176ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000270176ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000270176ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000420247ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000420247ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000420247ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000420247ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000420247ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
In-frameENST00000533862ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000533862ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000533862ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000533862ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000533862ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
In-frameENST00000279270ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000279270ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000279270ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000279270ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000279270ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000524944ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000524944ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000524944ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000524944ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000524944ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
intron-3CDSENST00000527009ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
intron-3CDSENST00000527009ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
intron-intronENST00000527009ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
intron-intronENST00000527009ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
intron-intronENST00000527009ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000534462ENST00000324695SCYL1chr11

65306175

-TRPM8chr2

234826043

+
Frame-shiftENST00000534462ENST00000433712SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000534462ENST00000355722SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000534462ENST00000409625SCYL1chr11

65306175

-TRPM8chr2

234826043

+
5CDS-intronENST00000534462ENST00000466594SCYL1chr11

65306175

-TRPM8chr2

234826043

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525364SCYL1chr1165306175-ENST00000324695TRPM8chr2234826043+82052584262459381104
ENST00000533862SCYL1chr1165306175-ENST00000324695TRPM8chr2234826043+81912570261059241104
ENST00000279270SCYL1chr1165306175-ENST00000324695TRPM8chr2234826043+81692548258859021104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525364ENST00000324695SCYL1chr1165306175-TRPM8chr2234826043+0.0094354070.9905646
ENST00000533862ENST00000324695SCYL1chr1165306175-TRPM8chr2234826043+0.0092323280.99076766
ENST00000279270ENST00000324695SCYL1chr1165306175-TRPM8chr2234826043+0.0091593090.9908407

Top

Fusion Genomic Features for SCYL1-TRPM8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SCYL1-TRPM8


check button Go to

FGviewer for the breakpoints of chr11:65306175-chr2:234826043

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TRPM8

TCAF1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.921

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818761_797855.0809.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717761_797835.6666666666666782.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818761_797838.0792.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818761_797842.6666666666666788.0Coiled coilOntology_term=ECO:0000255
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818589_619855.0809.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717589_619835.6666666666666782.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818589_619838.0792.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818589_619842.6666666666666788.0Compositional biasNote=Pro-rich
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-181814_314855.0809.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-171714_314835.6666666666666782.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-181814_314838.0792.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-181814_314842.6666666666666788.0DomainProtein kinase
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818350_388855.0809.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818389_427855.0809.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818507_545855.0809.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717350_388835.6666666666666782.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717389_427835.6666666666666782.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717507_545835.6666666666666782.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818350_388838.0792.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818389_427838.0792.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818507_545838.0792.0RepeatNote=HEAT 3
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818350_388842.6666666666666788.0RepeatNote=HEAT 1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818389_427842.6666666666666788.0RepeatNote=HEAT 2
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818507_545842.6666666666666788.0RepeatNote=HEAT 3
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-1261071_110401834.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneTRPM8chr11:65306175chr2:234826043ENST00000355722051071_11040193.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM8chr11:65306175chr2:234826043ENST00000409625051071_11040166.0Coiled coilOntology_term=ECO:0000255
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126187_19501834.6666666666667RegionNote=Epitope%3B activates specific cytotoxic T lymphocytes
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205187_1950193.0RegionNote=Epitope%3B activates specific cytotoxic T lymphocytes
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505187_1950166.0RegionNote=Epitope%3B activates specific cytotoxic T lymphocytes
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-1261_69101834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126713_73401834.6666666666667Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126756_75901834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126781_79401834.6666666666667Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126816_82901834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126851_95801834.6666666666667Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126980_110401834.6666666666667Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000355722051_6910193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205713_7340193.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205756_7590193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205781_7940193.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205816_8290193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205851_9580193.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205980_11040193.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000409625051_6910166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505713_7340166.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505756_7590166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505781_7940166.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505816_8290166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505851_9580166.0Topological domainExtracellular
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505980_11040166.0Topological domainCytoplasmic
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126692_71201834.6666666666667TransmembraneHelical%3B Name%3D1
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126735_75501834.6666666666667TransmembraneHelical%3B Name%3D2
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126760_78001834.6666666666667TransmembraneHelical%3B Name%3D3
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126795_81501834.6666666666667TransmembraneHelical%3B Name%3D4
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126830_85001834.6666666666667TransmembraneHelical%3B Name%3D5
TgeneTRPM8chr11:65306175chr2:234826043ENST00000324695-126959_97901834.6666666666667TransmembraneHelical%3B Name%3D6
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205692_7120193.0TransmembraneHelical%3B Name%3D1
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205735_7550193.0TransmembraneHelical%3B Name%3D2
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205760_7800193.0TransmembraneHelical%3B Name%3D3
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205795_8150193.0TransmembraneHelical%3B Name%3D4
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205830_8500193.0TransmembraneHelical%3B Name%3D5
TgeneTRPM8chr11:65306175chr2:234826043ENST0000035572205959_9790193.0TransmembraneHelical%3B Name%3D6
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505692_7120166.0TransmembraneHelical%3B Name%3D1
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505735_7550166.0TransmembraneHelical%3B Name%3D2
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505760_7800166.0TransmembraneHelical%3B Name%3D3
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505795_8150166.0TransmembraneHelical%3B Name%3D4
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505830_8500166.0TransmembraneHelical%3B Name%3D5
TgeneTRPM8chr11:65306175chr2:234826043ENST0000040962505959_9790166.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for SCYL1-TRPM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000525364_ENST00000324695_TCGA-EJ-7327-01A_SCYL1_chr11_65306175_-_TRPM8_chr2_234826043_length(transcript)=8205nt_BP=2584nt
CTCTCCGCCCCGCCCCGGCTCGGGCGGCCGGAGGACCCGGAGCTAAGGCGCCCGAACCCGCGGCGGCGGTGGGGACGATGTGGTTCTTTG
CCCGGGACCCGGTCCGGGACTTTCCGTTCGAGCTCATCCCGGAGCCCCCAGAGGGCGGCCTGCCCGGGCCCTGGGCCCTGCACCGCGGCC
GCAAGAAGGCCACAGGCAGCCCCGTGTCCATCTTCGTCTATGATGTGAAGCCTGGCGCGGAAGAGCAGACCCAGGTGGCCAAAGCTGCCT
TCAAGCGCTTCAAAACTCTACGGCACCCCAACATCCTGGCTTACATCGATGGACTGGAGACAGAAAAATGCCTCCACGTCGTGACAGAGG
CTGTGACCCCGTTGGGAATATACCTCAAGGCGAGAGTGGAGGCTGGTGGCCTGAAGGAGCTGGAGATCTCCTGGGGGCTACACCAGATCG
TGAAAGCCCTCAGCTTCCTGGTCAACGACTGCAGCCTCATCCACAACAATGTCTGCATGGCCGCCGTGTTCGTGGACCGAGCTGGCGAGT
GGAAGCTTGGGGGCCTGGACTACATGTATTCGGCCCAGGGCAACGGTGGGGGACCTCCCCGCAAGGGGATCCCCGAGCTTGAGCAGTATG
ACCCCCCGGAGTTGGCTGACAGCAGTGGCAGAGTGGTCAGAGAGAAGTGGTCAGCAGACATGTGGCGCTTGGGCTGCCTCATTTGGGAAG
TCTTCAATGGGCCCCTACCTCGGGCAGCAGCCCTACGCAACCCTGGGAAGATCCCCAAAACGCTGGTGCCCCATTACTGTGAGCTGGTGG
GAGCAAACCCCAAGGTGCGTCCCAACCCAGCCCGCTTCCTGCAGAACTGCCGGGCACCTGGTGGCTTCATGAGCAACCGCTTTGTAGAAA
CCAACCTCTTCCTGGAGGAGATTCAGATCAAAGAGCCAGCCGAGAAGCAAAAATTCTTCCAGGAGCTGAGCAAGAGCCTGGACGCATTCC
CTGAGGATTTCTGTCGGCACAAGGTGCTGCCCCAGCTGCTGACCGCCTTCGAGTTCGGCAATGCTGGGGCCGTTGTCCTCACGCCCCTCT
TCAAGGTGGGCAAGTTCCTGAGCGCTGAGGAGTATCAGCAGAAGATCATCCCTGTGGTGGTCAAGATGTTCTCATCCACTGACCGGGCCA
TGCGCATCCGCCTCCTGCAGCAGATGGAGCAGTTCATCCAGTACCTTGACGAGCCAACAGTCAACACCCAGATCTTCCCCCACGTCGTAC
ATGGCTTCCTGGACACCAACCCTGCCATCCGGGAGCAGACGGTCAAGTCCATGCTGCTCCTGGCCCCAAAGCTGAACGAGGCCAACCTCA
ATGTGGAGCTGATGAAGCACTTTGCACGGCTACAGGCCAAGGATGAACAGGGCCCCATCCGCTGCAACACCACAGTCTGCCTGGGCAAAA
TCGGCTCCTACCTCAGTGCTAGCACCAGACACAGGGTCCTTACCTCTGCCTTCAGCCGAGCCACTAGGGACCCGTTTGCACCGTCCCGGG
TTGCGGGTGTCCTGGGCTTTGCTGCCACCCACAACCTCTACTCAATGAACGACTGTGCCCAGAAGATCCTGCCTGTGCTCTGCGGTCTCA
CTGTAGATCCTGAGAAATCCGTGCGAGACCAGGCCTTCAAGGCCATTCGGAGCTTCCTGTCCAAATTGGAGTCTGTGTCGGAGGACCCGA
CCCAGCTGGAGGAAGTGGAGAAGGATGTCCATGCAGCCTCCAGCCCTGGCATGGGAGGAGCCGCAGCTAGCTGGGCAGGCTGGGCCGTGA
CCGGGGTCTCCTCACTCACCTCCAAGCTGATCCGTTCGCACCCAACCACTGCCCCAACAGAAACCAACATTCCCCAAAGACCCACGCCTG
AAGGAGTTCCTGCCCCAGCCCCCACCCCTGTTCCTGCCACCCCTACAACCTCAGGCCACTGGGAGACGCAGGAGGAGGACAAGGACACAG
CAGAGGACAGCAGCACTGCTGACAGATGGGACGACGAAGACTGGGGCAGCCTGGAGGAGGCCGAGTCTGTGCTGGCCCAGCAGGACGACT
GGAGCACCGGGGGCCAAGTGAGCCGTGCTAGTCAGGTCAGCAACTCCGACCACAAATCCTCCAAATCCCCAGAGTCCGACTGGAGCAGCT
GGGAAGCTGAGGGCTCCTGGGAACAGGGCTGGCAGGAGCCAAGCTCCCAGGAGCCACCTCCTGACGGTACACGGCTGGCCAGCGAGTATA
ACTGGGGTGGCCCAGAGTCCAGCGACAAGGGCGACCCCTTCGCTACCCTGTCTGCACGTCCCAGCACCCAGGACAGGTCAAGGCTGAGCT
GGCCCGGAAGAAGCGCGAGGAGCGGCGGCGGGAGATGGAGGCCAAACGCGCCGAGAGGAAGGTGGCCAAGGGCCCCATGAAGCTGGGAGC
CCGGAAGCTGGACTGAACCGTGGCGGTGGCCCTTCCCGGCTGCGGAGAGCCCGCCCCACAGATGTATTTATTGTACAAACCATGTGAGCC
CGGCCGGCCCAGCCAGGCCATCTCACGTGTACATAATCAGAGCCACAATAAATTCTATTTCACAAAGAAAATCCTGCTTGACAAAAACCG
TCACTTAGGAAAAGATGTCCTTTCGGGCAGCCAGGCTCAGCATGAGGAACAGAAGGAATGACACTCTGGACAGCACCCGGACCCTGTACT
CCAGCGCGTCTCGGAGCACAGACTTGTCTTACAGTGAAAGCGACTTGGTGAATTTTATTCAAGCAAATTTTAAGAAACGAGAATGTGTCT
TCTTTACCAAAGATTCCAAGGCCACGGAGAATGTGTGCAAGTGTGGCTATGCCCAGAGCCAGCACATGGAAGGCACCCAGATCAACCAAA
GTGAGAAATGGAACTACAAGAAACACACCAAGGAATTTCCTACCGACGCCTTTGGGGATATTCAGTTTGAGACACTGGGGAAGAAAGGGA
AGTATATACGTCTGTCCTGCGACACGGACGCGGAAATCCTTTACGAGCTGCTGACCCAGCACTGGCACCTGAAAACACCCAACCTGGTCA
TTTCTGTGACCGGGGGCGCCAAGAACTTCGCCCTGAAGCCGCGCATGCGCAAGATCTTCAGCCGGCTCATCTACATCGCGCAGTCCAAAG
GTGCTTGGATTCTCACGGGAGGCACCCATTATGGCCTGATGAAGTACATCGGGGAGGTGGTGAGAGATAACACCATCAGCAGGAGTTCAG
AGGAGAATATTGTGGCCATTGGCATAGCAGCTTGGGGCATGGTCTCCAACCGGGACACCCTCATCAGGAATTGCGATGCTGAGGGCTATT
TTTTAGCCCAGTACCTTATGGATGACTTCACAAGAGATCCACTGTATATCCTGGACAACAACCACACACATTTGCTGCTCGTGGACAATG
GCTGTCATGGACATCCCACTGTCGAAGCAAAGCTCCGGAATCAGCTAGAGAAGTATATCTCTGAGCGCACTATTCAAGATTCCAACTATG
GTGGCAAGATCCCCATTGTGTGTTTTGCCCAAGGAGGTGGAAAAGAGACTTTGAAAGCCATCAATACCTCCATCAAAAATAAAATTCCTT
GTGTGGTGGTGGAAGGCTCGGGCCAGATCGCTGATGTGATCGCTAGCCTGGTGGAGGTGGAGGATGCCCTGACATCTTCTGCCGTCAAGG
AGAAGCTGGTGCGCTTTTTACCCCGCACGGTGTCCCGGCTGCCTGAGGAGGAGACTGAGAGTTGGATCAAATGGCTCAAAGAAATTCTCG
AATGTTCTCACCTATTAACAGTTATTAAAATGGAAGAAGCTGGGGATGAAATTGTGAGCAATGCCATCTCCTACGCTCTATACAAAGCCT
TCAGCACCAGTGAGCAAGACAAGGATAACTGGAATGGGCAGCTGAAGCTTCTGCTGGAGTGGAACCAGCTGGACTTAGCCAATGATGAGA
TTTTCACCAATGACCGCCGATGGGAGTCTGCTGACCTTCAAGAAGTCATGTTTACGGCTCTCATAAAGGACAGACCCAAGTTTGTCCGCC
TCTTTCTGGAGAATGGCTTGAACCTACGGAAGTTTCTCACCCATGATGTCCTCACTGAACTCTTCTCCAACCACTTCAGCACGCTTGTGT
ACCGGAATCTGCAGATCGCCAAGAATTCCTATAATGATGCCCTCCTCACGTTTGTCTGGAAACTGGTTGCGAACTTCCGAAGAGGCTTCC
GGAAGGAAGACAGAAATGGCCGGGACGAGATGGACATAGAACTCCACGACGTGTCTCCTATTACTCGGCACCCCCTGCAAGCTCTCTTCA
TCTGGGCCATTCTTCAGAATAAGAAGGAACTCTCCAAAGTCATTTGGGAGCAGACCAGGGGCTGCACTCTGGCAGCCCTGGGAGCCAGCA
AGCTTCTGAAGACTCTGGCCAAAGTGAAGAACGACATCAATGCTGCTGGGGAGTCCGAGGAGCTGGCTAATGAGTACGAGACCCGGGCTG
TTGAGCTGTTCACTGAGTGTTACAGCAGCGATGAAGACTTGGCAGAACAGCTGCTGGTCTATTCCTGTGAAGCTTGGGGTGGAAGCAACT
GTCTGGAGCTGGCGGTGGAGGCCACAGACCAGCATTTCATCGCCCAGCCTGGGGTCCAGAATTTTCTTTCTAAGCAATGGTATGGAGAGA
TTTCCCGAGACACCAAGAACTGGAAGATTATCCTGTGTCTGTTTATTATACCCTTGGTGGGCTGTGGCTTTGTATCATTTAGGAAGAAAC
CTGTCGACAAGCACAAGAAGCTGCTTTGGTACTATGTGGCGTTCTTCACCTCCCCCTTCGTGGTCTTCTCCTGGAATGTGGTCTTCTACA
TCGCCTTCCTCCTGCTGTTTGCCTACGTGCTGCTCATGGATTTCCATTCGGTGCCACACCCCCCCGAGCTGGTCCTGTACTCGCTGGTCT
TTGTCCTCTTCTGTGATGAAGTGAGACAGTGGTACGTAAATGGGGTGAATTATTTTACTGACCTGTGGAATGTGATGGACACGCTGGGGC
TTTTTTACTTCATAGCAGGAATTGTATTTCGGCTCCACTCTTCTAATAAAAGCTCTTTGTATTCTGGACGAGTCATTTTCTGTCTGGACT
ACATTATTTTCACTCTAAGATTGATCCACATTTTTACTGTAAGCAGAAACTTAGGACCCAAGATTATAATGCTGCAGAGGATGCTGATCG
ATGTGTTCTTCTTCCTGTTCCTCTTTGCGGTGTGGATGGTGGCCTTTGGCGTGGCCAGGCAAGGGATCCTTAGGCAGAATGAGCAGCGCT
GGAGGTGGATATTCCGTTCGGTCATCTACGAGCCCTACCTGGCCATGTTCGGCCAGGTGCCCAGTGACGTGGATGGTACCACGTATGACT
TTGCCCACTGCACCTTCACTGGGAATGAGTCCAAGCCACTGTGTGTGGAGCTGGATGAGCACAACCTGCCCCGGTTCCCCGAGTGGATCA
CCATCCCCCTGGTGTGCATCTACATGTTATCCACCAACATCCTGCTGGTCAACCTGCTGGTCGCCATGTTTGGCTACACGGTGGGCACCG
TCCAGGAGAACAATGACCAGGTCTGGAAGTTCCAGAGGTACTTCCTGGTGCAGGAGTACTGCAGCCGCCTCAATATCCCCTTCCCCTTCA
TCGTCTTCGCTTACTTCTACATGGTGGTGAAGAAGTGCTTCAAGTGTTGCTGCAAGGAGAAAAACATGGAGTCTTCTGTCTGCTGTTTCA
AAAATGAAGACAATGAGACTCTGGCATGGGAGGGTGTCATGAAGGAAAACTACCTTGTCAAGATCAACACAAAAGCCAACGACACCTCAG
AGGAAATGAGGCATCGATTTAGACAACTGGATACAAAGCTTAATGATCTCAAGGGTCTTCTGAAAGAGATTGCTAATAAAATCAAATAAA
ACTGTATGAACTCTAATGGAGAAAAATCTAATTATAGCAAGATCATATTAAGGAATGCTGATGAACAATTTTGCTATCGACTACTAAATG
AGAGATTTTCAGACCCCTGGGTACATGGTGGATGATTTTAAATCACCCTAGTGTGCTGAGACCTTGAGAATAAAGTGTGTGATTGGTTTC
ATACTTGAAGACGGATATAAAGGAAGAATATTTCCTTTATGTGTTTCTCCAGAATGGTGCCTGTTTCTCTCTGTGTCTCAATGCCTGGGA
CTGGAGGTTGATAGTTTAAGTGTGTTCTTACCGCCTCCTTTTTCCTTTAATCTTATTTTTGATGAACACATATATAGGAGAACATCTATC
CTATGAATAAGAACCTGGTCATGCTTTACTCCTGTATTGTTATTTTGTTCATTTCCAATTGATTCTCTACTTTTCCCTTTTTTGTATTAT
GTGACTAATTAGTTGGCATATTGTTAAAAGTCTCTCAAATTAGGCCAGATTCTAAAACATGCTGCAGCAAGAGGACCCCGCTCTCTTCAG
GAAAAGTGTTTTCATTTCTCAGGATGCTTCTTACCTGTCAGAGGAGGTGACAAGGCAGTCTCTTGCTCTCTTGGACTCACCAGGCTCCTA
TTGAAGGAACCACCCCCATTCCTAAATATGTGAAAAGTCGCCCAAAATGCAACCTTGAAAGGCACTACTGACTTTGTTCTTATTGGATAC
TCCTCTTATTATTTTTCCATTAAAAATAATAGCTGGCTATTATAGAAAATTTAGACCATACAGAGATGTAGAAAGAACATAAATTGTCCC
CATTACCTTAAGGTAATCACTGCTAACAATTTCTGGATGGTTTTTCAAGTCTATTTTTTTTCTATGTATGTCTCAATTCTCTTTCAAAAT
TTTACAGAATGTTATCATACTACATATATACTTTTTATGTAAGCTTTTTCACTTAGTATTTTATCAAATATGTTTTTATTATATTCATAG
CCTTCTTAAACATTATATCAATAATTGCATAATAGGCAACCTCTAGCGATTACCATAATTTTGCTCATTGAAGGCTATCTCCAGTTGATC
ATTGGGATGAGCATCTTTGTGCATGAATCCTATTGCTGTATTTGGGAAAATTTTCCAAGGTTAGATTCCAATAAATATCTATTTATTATT
AAATATTAAAATATCTATTTATTATTAAAACCATTTATAAGGCTTTTTCATAAATGTATAGCAAATAGGAATTATTAACTTGAGCATAAG
ATATGAGATACATGAACCTGAACTATTAAAATAAAATATTATATTTAACCCTTAGTTTAAGAAGAAGTCAATATGCTTATTTAAATATTA
TGGATGGTGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCACATCTCTACTAAAAATAAAAAAATT
AGCTGGGTGTGGTGGTGCACTCCTGTAATCCCAGCTACTCAGAAGGCTGAGGTACAAGAATTGCTGGAACCTGGGAGGCGGAGGTTGCAG
TGAACCAAGATTGCACCACTGCACTCCAGCCGGGGTGACAGAGTGAGACTCCGACTGAAAATAAATAAATAAATAAATAAATAAATAAAT
AAATATTATGGATGGTGAAGGGAATGGTATAGAATTGGAGAGATTATCTTACTGAACACCTGTAGTCCCAGCTTTCTCTGGAAGTGGTCG
TATTTGAGCAGGATGTGCACAAGGCAATTGAAATGCCCATAATTAGTTTCTCAGCTTTGAATACACTATAAACTCACTGGCTGAAGGAGG
AAATTTTAGAAGGAAGCTACTAAAAGATCTAATTTGAAAAACTACAAAAGCATTAACTAAAAAAGTTTATTTTCCTTTTGTCTGGGCAGT
AGTGAAAATAACTACTCACAACATTCACTATGTTTGCAAGGAATTAACACAAATAAAAGATGCCTTTTTACTTAAACACCAAGACAGAAA
ACTTGCCCAATACTGAGAAGCAACTTGCATTAGAGAGGGAACTGTTAAATGTTTTCAACCCAGTTCATCTGGTGGATGTTTTTGCAGGTT
ACTCTGAGAATTTTGCTTATGAAAAATCATTATTTTTAGTGTAGTTCACAATAATGTATTGAACATACTTCTAATCAAAGGTGCTATGTC
CTTGTGTATGGTACTAAATGTGTCCTGTGTACTTTTGCACAACTGAGAATCCTGCAGCTTGGTTTAATGAGTGTGTTCATGAAATAAATA

>In-frame_ENST00000525364_ENST00000324695_TCGA-EJ-7327-01A_SCYL1_chr11_65306175_-_TRPM8_chr2_234826043_length(amino acids)=1104AA_start in transcript=2624_stop in transcript=5938
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN
YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGH
PTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT
ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN
DQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH

--------------------------------------------------------------
>In-frame_ENST00000533862_ENST00000324695_TCGA-EJ-7327-01A_SCYL1_chr11_65306175_-_TRPM8_chr2_234826043_length(transcript)=8191nt_BP=2570nt
CCCGGAGCTAAGGCGCCCGAACCCGCGGCGGCGGTGGGGACGATGTGGTTCTTTGCCCGGGACCCGGTCCGGGACTTTCCGTTCGAGCTC
ATCCCGGAGCCCCCAGAGGGCGGCCTGCCCGGGCCCTGGGCCCTGCACCGCGGCCGCAAGAAGGCCACAGGCAGCCCCGTGTCCATCTTC
GTCTATGATGTGAAGCCTGGCGCGGAAGAGCAGACCCAGGTGGCCAAAGCTGCCTTCAAGCGCTTCAAAACTCTACGGCACCCCAACATC
CTGGCTTACATCGATGGACTGGAGACAGAAAAATGCCTCCACGTCGTGACAGAGGCTGTGACCCCGTTGGGAATATACCTCAAGGCGAGA
GTGGAGGCTGGTGGCCTGAAGGAGCTGGAGATCTCCTGGGGGCTACACCAGATCGTGAAAGCCCTCAGCTTCCTGGTCAACGACTGCAGC
CTCATCCACAACAATGTCTGCATGGCCGCCGTGTTCGTGGACCGAGCTGGCGAGTGGAAGCTTGGGGGCCTGGACTACATGTATTCGGCC
CAGGGCAACGGTGGGGGACCTCCCCGCAAGGGGATCCCCGAGCTTGAGCAGTATGACCCCCCGGAGTTGGCTGACAGCAGTGGCAGAGTG
GTCAGAGAGAAGTGGTCAGCAGACATGTGGCGCTTGGGCTGCCTCATTTGGGAAGTCTTCAATGGGCCCCTACCTCGGGCAGCAGCCCTA
CGCAACCCTGGGAAGATCCCCAAAACGCTGGTGCCCCATTACTGTGAGCTGGTGGGAGCAAACCCCAAGGTGCGTCCCAACCCAGCCCGC
TTCCTGCAGAACTGCCGGGCACCTGGTGGCTTCATGAGCAACCGCTTTGTAGAAACCAACCTCTTCCTGGAGGAGATTCAGATCAAAGAG
CCAGCCGAGAAGCAAAAATTCTTCCAGGAGCTGAGCAAGAGCCTGGACGCATTCCCTGAGGATTTCTGTCGGCACAAGGTGCTGCCCCAG
CTGCTGACCGCCTTCGAGTTCGGCAATGCTGGGGCCGTTGTCCTCACGCCCCTCTTCAAGGTGGGCAAGTTCCTGAGCGCTGAGGAGTAT
CAGCAGAAGATCATCCCTGTGGTGGTCAAGATGTTCTCATCCACTGACCGGGCCATGCGCATCCGCCTCCTGCAGCAGATGGAGCAGTTC
ATCCAGTACCTTGACGAGCCAACAGTCAACACCCAGATCTTCCCCCACGTCGTACATGGCTTCCTGGACACCAACCCTGCCATCCGGGAG
CAGACGGTCAAGTCCATGCTGCTCCTGGCCCCAAAGCTGAACGAGGCCAACCTCAATGTGGAGCTGATGAAGCACTTTGCACGGCTACAG
GCCAAGGATGAACAGGGCCCCATCCGCTGCAACACCACAGTCTGCCTGGGCAAAATCGGCTCCTACCTCAGTGCTAGCACCAGACACAGG
GTCCTTACCTCTGCCTTCAGCCGAGCCACTAGGGACCCGTTTGCACCGTCCCGGGTTGCGGGTGTCCTGGGCTTTGCTGCCACCCACAAC
CTCTACTCAATGAACGACTGTGCCCAGAAGATCCTGCCTGTGCTCTGCGGTCTCACTGTAGATCCTGAGAAATCCGTGCGAGACCAGGCC
TTCAAGGCCATTCGGAGCTTCCTGTCCAAATTGGAGTCTGTGTCGGAGGACCCGACCCAGCTGGAGGAAGTGGAGAAGGATGTCCATGCA
GCCTCCAGCCCTGGCATGGGAGGAGCCGCAGCTAGCTGGGCAGGCTGGGCCGTGACCGGGGTCTCCTCACTCACCTCCAAGCTGATCCGT
TCGCACCCAACCACTGCCCCAACAGAAACCAACATTCCCCAAAGACCCACGCCTGAAGGAGTTCCTGCCCCAGCCCCCACCCCTGTTCCT
GCCACCCCTACAACCTCAGGCCACTGGGAGACGCAGGAGGAGGACAAGGACACAGCAGAGGACAGCAGCACTGCTGACAGATGGGACGAC
GAAGACTGGGGCAGCCTGGAGCAGGAGGCCGAGTCTGTGCTGGCCCAGCAGGACGACTGGAGCACCGGGGGCCAAGTGAGCCGTGCTAGT
CAGAGTCCGACTGGAGCAGCTGGGAAGCTGAGGGCTCCTGGGAACAGGGCTGGCAGGAGCCAAGCTCCCAGGAGCCACCTCCTGACGGTA
CACGGCTGGCCAGCGAGTATAACTGGGGTGGCCCAGAGTCCAGCGACAAGGGCGACCCCTTCGCTACCCTGTCTGCACGTCCCAGCACCC
AGCCGAGGCCAGACTCTTGGGGTGAGGACAACTGGGAGGGCCTCGAGACTGACAGTCGACAGGTCAAGGCTGAGCTGGCCCGGAAGAAGC
GCGAGGAGCGGCGGCGGGAGATGGAGGCCAAACGCGCCGAGAGGAAGGTGGCCAAGGGCCCCATGAAGCTGGGAGCCCGGAAGCTGGACT
GAACCGTGGCGGTGGCCCTTCCCGGCTGCGGAGAGCCCGCCCCACAGATGTATTTATTGTACAAACCATGTGAGCCCGGCCGGCCCAGCC
AGGCCATCTCACGTGTACATAATCAGAGCCACAATAAATTCTATTTCACAAAGAAAATCCTGCTTGACAAAAACCGTCACTTAGGAAAAG
ATGTCCTTTCGGGCAGCCAGGCTCAGCATGAGGAACAGAAGGAATGACACTCTGGACAGCACCCGGACCCTGTACTCCAGCGCGTCTCGG
AGCACAGACTTGTCTTACAGTGAAAGCGACTTGGTGAATTTTATTCAAGCAAATTTTAAGAAACGAGAATGTGTCTTCTTTACCAAAGAT
TCCAAGGCCACGGAGAATGTGTGCAAGTGTGGCTATGCCCAGAGCCAGCACATGGAAGGCACCCAGATCAACCAAAGTGAGAAATGGAAC
TACAAGAAACACACCAAGGAATTTCCTACCGACGCCTTTGGGGATATTCAGTTTGAGACACTGGGGAAGAAAGGGAAGTATATACGTCTG
TCCTGCGACACGGACGCGGAAATCCTTTACGAGCTGCTGACCCAGCACTGGCACCTGAAAACACCCAACCTGGTCATTTCTGTGACCGGG
GGCGCCAAGAACTTCGCCCTGAAGCCGCGCATGCGCAAGATCTTCAGCCGGCTCATCTACATCGCGCAGTCCAAAGGTGCTTGGATTCTC
ACGGGAGGCACCCATTATGGCCTGATGAAGTACATCGGGGAGGTGGTGAGAGATAACACCATCAGCAGGAGTTCAGAGGAGAATATTGTG
GCCATTGGCATAGCAGCTTGGGGCATGGTCTCCAACCGGGACACCCTCATCAGGAATTGCGATGCTGAGGGCTATTTTTTAGCCCAGTAC
CTTATGGATGACTTCACAAGAGATCCACTGTATATCCTGGACAACAACCACACACATTTGCTGCTCGTGGACAATGGCTGTCATGGACAT
CCCACTGTCGAAGCAAAGCTCCGGAATCAGCTAGAGAAGTATATCTCTGAGCGCACTATTCAAGATTCCAACTATGGTGGCAAGATCCCC
ATTGTGTGTTTTGCCCAAGGAGGTGGAAAAGAGACTTTGAAAGCCATCAATACCTCCATCAAAAATAAAATTCCTTGTGTGGTGGTGGAA
GGCTCGGGCCAGATCGCTGATGTGATCGCTAGCCTGGTGGAGGTGGAGGATGCCCTGACATCTTCTGCCGTCAAGGAGAAGCTGGTGCGC
TTTTTACCCCGCACGGTGTCCCGGCTGCCTGAGGAGGAGACTGAGAGTTGGATCAAATGGCTCAAAGAAATTCTCGAATGTTCTCACCTA
TTAACAGTTATTAAAATGGAAGAAGCTGGGGATGAAATTGTGAGCAATGCCATCTCCTACGCTCTATACAAAGCCTTCAGCACCAGTGAG
CAAGACAAGGATAACTGGAATGGGCAGCTGAAGCTTCTGCTGGAGTGGAACCAGCTGGACTTAGCCAATGATGAGATTTTCACCAATGAC
CGCCGATGGGAGTCTGCTGACCTTCAAGAAGTCATGTTTACGGCTCTCATAAAGGACAGACCCAAGTTTGTCCGCCTCTTTCTGGAGAAT
GGCTTGAACCTACGGAAGTTTCTCACCCATGATGTCCTCACTGAACTCTTCTCCAACCACTTCAGCACGCTTGTGTACCGGAATCTGCAG
ATCGCCAAGAATTCCTATAATGATGCCCTCCTCACGTTTGTCTGGAAACTGGTTGCGAACTTCCGAAGAGGCTTCCGGAAGGAAGACAGA
AATGGCCGGGACGAGATGGACATAGAACTCCACGACGTGTCTCCTATTACTCGGCACCCCCTGCAAGCTCTCTTCATCTGGGCCATTCTT
CAGAATAAGAAGGAACTCTCCAAAGTCATTTGGGAGCAGACCAGGGGCTGCACTCTGGCAGCCCTGGGAGCCAGCAAGCTTCTGAAGACT
CTGGCCAAAGTGAAGAACGACATCAATGCTGCTGGGGAGTCCGAGGAGCTGGCTAATGAGTACGAGACCCGGGCTGTTGAGCTGTTCACT
GAGTGTTACAGCAGCGATGAAGACTTGGCAGAACAGCTGCTGGTCTATTCCTGTGAAGCTTGGGGTGGAAGCAACTGTCTGGAGCTGGCG
GTGGAGGCCACAGACCAGCATTTCATCGCCCAGCCTGGGGTCCAGAATTTTCTTTCTAAGCAATGGTATGGAGAGATTTCCCGAGACACC
AAGAACTGGAAGATTATCCTGTGTCTGTTTATTATACCCTTGGTGGGCTGTGGCTTTGTATCATTTAGGAAGAAACCTGTCGACAAGCAC
AAGAAGCTGCTTTGGTACTATGTGGCGTTCTTCACCTCCCCCTTCGTGGTCTTCTCCTGGAATGTGGTCTTCTACATCGCCTTCCTCCTG
CTGTTTGCCTACGTGCTGCTCATGGATTTCCATTCGGTGCCACACCCCCCCGAGCTGGTCCTGTACTCGCTGGTCTTTGTCCTCTTCTGT
GATGAAGTGAGACAGTGGTACGTAAATGGGGTGAATTATTTTACTGACCTGTGGAATGTGATGGACACGCTGGGGCTTTTTTACTTCATA
GCAGGAATTGTATTTCGGCTCCACTCTTCTAATAAAAGCTCTTTGTATTCTGGACGAGTCATTTTCTGTCTGGACTACATTATTTTCACT
CTAAGATTGATCCACATTTTTACTGTAAGCAGAAACTTAGGACCCAAGATTATAATGCTGCAGAGGATGCTGATCGATGTGTTCTTCTTC
CTGTTCCTCTTTGCGGTGTGGATGGTGGCCTTTGGCGTGGCCAGGCAAGGGATCCTTAGGCAGAATGAGCAGCGCTGGAGGTGGATATTC
CGTTCGGTCATCTACGAGCCCTACCTGGCCATGTTCGGCCAGGTGCCCAGTGACGTGGATGGTACCACGTATGACTTTGCCCACTGCACC
TTCACTGGGAATGAGTCCAAGCCACTGTGTGTGGAGCTGGATGAGCACAACCTGCCCCGGTTCCCCGAGTGGATCACCATCCCCCTGGTG
TGCATCTACATGTTATCCACCAACATCCTGCTGGTCAACCTGCTGGTCGCCATGTTTGGCTACACGGTGGGCACCGTCCAGGAGAACAAT
GACCAGGTCTGGAAGTTCCAGAGGTACTTCCTGGTGCAGGAGTACTGCAGCCGCCTCAATATCCCCTTCCCCTTCATCGTCTTCGCTTAC
TTCTACATGGTGGTGAAGAAGTGCTTCAAGTGTTGCTGCAAGGAGAAAAACATGGAGTCTTCTGTCTGCTGTTTCAAAAATGAAGACAAT
GAGACTCTGGCATGGGAGGGTGTCATGAAGGAAAACTACCTTGTCAAGATCAACACAAAAGCCAACGACACCTCAGAGGAAATGAGGCAT
CGATTTAGACAACTGGATACAAAGCTTAATGATCTCAAGGGTCTTCTGAAAGAGATTGCTAATAAAATCAAATAAAACTGTATGAACTCT
AATGGAGAAAAATCTAATTATAGCAAGATCATATTAAGGAATGCTGATGAACAATTTTGCTATCGACTACTAAATGAGAGATTTTCAGAC
CCCTGGGTACATGGTGGATGATTTTAAATCACCCTAGTGTGCTGAGACCTTGAGAATAAAGTGTGTGATTGGTTTCATACTTGAAGACGG
ATATAAAGGAAGAATATTTCCTTTATGTGTTTCTCCAGAATGGTGCCTGTTTCTCTCTGTGTCTCAATGCCTGGGACTGGAGGTTGATAG
TTTAAGTGTGTTCTTACCGCCTCCTTTTTCCTTTAATCTTATTTTTGATGAACACATATATAGGAGAACATCTATCCTATGAATAAGAAC
CTGGTCATGCTTTACTCCTGTATTGTTATTTTGTTCATTTCCAATTGATTCTCTACTTTTCCCTTTTTTGTATTATGTGACTAATTAGTT
GGCATATTGTTAAAAGTCTCTCAAATTAGGCCAGATTCTAAAACATGCTGCAGCAAGAGGACCCCGCTCTCTTCAGGAAAAGTGTTTTCA
TTTCTCAGGATGCTTCTTACCTGTCAGAGGAGGTGACAAGGCAGTCTCTTGCTCTCTTGGACTCACCAGGCTCCTATTGAAGGAACCACC
CCCATTCCTAAATATGTGAAAAGTCGCCCAAAATGCAACCTTGAAAGGCACTACTGACTTTGTTCTTATTGGATACTCCTCTTATTATTT
TTCCATTAAAAATAATAGCTGGCTATTATAGAAAATTTAGACCATACAGAGATGTAGAAAGAACATAAATTGTCCCCATTACCTTAAGGT
AATCACTGCTAACAATTTCTGGATGGTTTTTCAAGTCTATTTTTTTTCTATGTATGTCTCAATTCTCTTTCAAAATTTTACAGAATGTTA
TCATACTACATATATACTTTTTATGTAAGCTTTTTCACTTAGTATTTTATCAAATATGTTTTTATTATATTCATAGCCTTCTTAAACATT
ATATCAATAATTGCATAATAGGCAACCTCTAGCGATTACCATAATTTTGCTCATTGAAGGCTATCTCCAGTTGATCATTGGGATGAGCAT
CTTTGTGCATGAATCCTATTGCTGTATTTGGGAAAATTTTCCAAGGTTAGATTCCAATAAATATCTATTTATTATTAAATATTAAAATAT
CTATTTATTATTAAAACCATTTATAAGGCTTTTTCATAAATGTATAGCAAATAGGAATTATTAACTTGAGCATAAGATATGAGATACATG
AACCTGAACTATTAAAATAAAATATTATATTTAACCCTTAGTTTAAGAAGAAGTCAATATGCTTATTTAAATATTATGGATGGTGGGCAG
ATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCACATCTCTACTAAAAATAAAAAAATTAGCTGGGTGTGGTG
GTGCACTCCTGTAATCCCAGCTACTCAGAAGGCTGAGGTACAAGAATTGCTGGAACCTGGGAGGCGGAGGTTGCAGTGAACCAAGATTGC
ACCACTGCACTCCAGCCGGGGTGACAGAGTGAGACTCCGACTGAAAATAAATAAATAAATAAATAAATAAATAAATAAATATTATGGATG
GTGAAGGGAATGGTATAGAATTGGAGAGATTATCTTACTGAACACCTGTAGTCCCAGCTTTCTCTGGAAGTGGTCGTATTTGAGCAGGAT
GTGCACAAGGCAATTGAAATGCCCATAATTAGTTTCTCAGCTTTGAATACACTATAAACTCACTGGCTGAAGGAGGAAATTTTAGAAGGA
AGCTACTAAAAGATCTAATTTGAAAAACTACAAAAGCATTAACTAAAAAAGTTTATTTTCCTTTTGTCTGGGCAGTAGTGAAAATAACTA
CTCACAACATTCACTATGTTTGCAAGGAATTAACACAAATAAAAGATGCCTTTTTACTTAAACACCAAGACAGAAAACTTGCCCAATACT
GAGAAGCAACTTGCATTAGAGAGGGAACTGTTAAATGTTTTCAACCCAGTTCATCTGGTGGATGTTTTTGCAGGTTACTCTGAGAATTTT
GCTTATGAAAAATCATTATTTTTAGTGTAGTTCACAATAATGTATTGAACATACTTCTAATCAAAGGTGCTATGTCCTTGTGTATGGTAC
TAAATGTGTCCTGTGTACTTTTGCACAACTGAGAATCCTGCAGCTTGGTTTAATGAGTGTGTTCATGAAATAAATAATGGAGGAATTGTC

>In-frame_ENST00000533862_ENST00000324695_TCGA-EJ-7327-01A_SCYL1_chr11_65306175_-_TRPM8_chr2_234826043_length(amino acids)=1104AA_start in transcript=2610_stop in transcript=5924
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN
YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGH
PTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT
ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN
DQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH

--------------------------------------------------------------
>In-frame_ENST00000279270_ENST00000324695_TCGA-EJ-7327-01A_SCYL1_chr11_65306175_-_TRPM8_chr2_234826043_length(transcript)=8169nt_BP=2548nt
CCGGAGCTAAGGCGCCCGAACCCGCGGCGGCGGTGGGGACGATGTGGTTCTTTGCCCGGGACCCGGTCCGGGACTTTCCGTTCGAGCTCA
TCCCGGAGCCCCCAGAGGGCGGCCTGCCCGGGCCCTGGGCCCTGCACCGCGGCCGCAAGAAGGCCACAGGCAGCCCCGTGTCCATCTTCG
TCTATGATGTGAAGCCTGGCGCGGAAGAGCAGACCCAGGTGGCCAAAGCTGCCTTCAAGCGCTTCAAAACTCTACGGCACCCCAACATCC
TGGCTTACATCGATGGACTGGAGACAGAAAAATGCCTCCACGTCGTGACAGAGGCTGTGACCCCGTTGGGAATATACCTCAAGGCGAGAG
TGGAGGCTGGTGGCCTGAAGGAGCTGGAGATCTCCTGGGGGCTACACCAGATCGTGAAAGCCCTCAGCTTCCTGGTCAACGACTGCAGCC
TCATCCACAACAATGTCTGCATGGCCGCCGTGTTCGTGGACCGAGCTGGCGAGTGGAAGCTTGGGGGCCTGGACTACATGTATTCGGCCC
AGGGCAACGGTGGGGGACCTCCCCGCAAGGGGATCCCCGAGCTTGAGCAGTATGACCCCCCGGAGTTGGCTGACAGCAGTGGCAGAGTGG
TCAGAGAGAAGTGGTCAGCAGACATGTGGCGCTTGGGCTGCCTCATTTGGGAAGTCTTCAATGGGCCCCTACCTCGGGCAGCAGCCCTAC
GCAACCCTGGGAAGATCCCCAAAACGCTGGTGCCCCATTACTGTGAGCTGGTGGGAGCAAACCCCAAGGTGCGTCCCAACCCAGCCCGCT
TCCTGCAGAACTGCCGGGCACCTGGTGGCTTCATGAGCAACCGCTTTGTAGAAACCAACCTCTTCCTGGAGGAGATTCAGATCAAAGAGC
CAGCCGAGAAGCAAAAATTCTTCCAGGAGCTGAGCAAGAGCCTGGACGCATTCCCTGAGGATTTCTGTCGGCACAAGGTGCTGCCCCAGC
TGCTGACCGCCTTCGAGTTCGGCAATGCTGGGGCCGTTGTCCTCACGCCCCTCTTCAAGGTGGGCAAGTTCCTGAGCGCTGAGGAGTATC
AGCAGAAGATCATCCCTGTGGTGGTCAAGATGTTCTCATCCACTGACCGGGCCATGCGCATCCGCCTCCTGCAGCAGATGGAGCAGTTCA
TCCAGTACCTTGACGAGCCAACAGTCAACACCCAGATCTTCCCCCACGTCGTACATGGCTTCCTGGACACCAACCCTGCCATCCGGGAGC
AGACGGTCAAGTCCATGCTGCTCCTGGCCCCAAAGCTGAACGAGGCCAACCTCAATGTGGAGCTGATGAAGCACTTTGCACGGCTACAGG
CCAAGGATGAACAGGGCCCCATCCGCTGCAACACCACAGTCTGCCTGGGCAAAATCGGCTCCTACCTCAGTGCTAGCACCAGACACAGGG
TCCTTACCTCTGCCTTCAGCCGAGCCACTAGGGACCCGTTTGCACCGTCCCGGGTTGCGGGTGTCCTGGGCTTTGCTGCCACCCACAACC
TCTACTCAATGAACGACTGTGCCCAGAAGATCCTGCCTGTGCTCTGCGGTCTCACTGTAGATCCTGAGAAATCCGTGCGAGACCAGGCCT
TCAAGGCCATTCGGAGCTTCCTGTCCAAATTGGAGTCTGTGTCGGAGGACCCGACCCAGCTGGAGGAAGTGGAGAAGGATGTCCATGCAG
CCTCCAGCCCTGGCATGGGAGGAGCCGCAGCTAGCTGGGCAGGCTGGGCCGTGACCGGGGTCTCCTCACTCACCTCCAAGCTGATCCGTT
CGCACCCAACCACTGCCCCAACAGAAACCAACATTCCCCAAAGACCCACGCCTGAAGGAGTTCCTGCCCCAGCCCCCACCCCTGTTCCTG
CCACCCCTACAACCTCAGGCCACTGGGAGACGCAGGAGGAGGACAAGGACACAGCAGAGGACAGCAGCACTGCTGACAGATGGGACGACG
AAGACTGGGGCAGCCTGGAGCAGGAGGCCGAGTCTGTGCTGGCCCAGCAGGACGACTGGAGCACCGGGGGCCAAGTGAGCCGTGCTAGTC
AGGTCAGCAACTCCGACCACAAATCCTCCAAATCCCCAGAGTCCGACTGGAGCAGCTGGGAAGCTGAGGGCTCCTGGGAACAGGGCTGGC
AGGAGCCAAGCTCCCAGGAGCCACCTCCTGACGGTACACGGCTGGCCAGCGAGTATAACTGGGGTGGCCCAGAGTCCAGCGACAAGGGCG
ACCCCTTCGCTACCCTGTCTGCACGTCCCAGCACCCAGGACAGGTCAAGGCTGAGCTGGCCCGGAAGAAGCGCGAGGAGCGGCGGCGGGA
GATGGAGGCCAAACGCGCCGAGAGGAAGGTGGCCAAGGGCCCCATGAAGCTGGGAGCCCGGAAGCTGGACTGAACCGTGGCGGTGGCCCT
TCCCGGCTGCGGAGAGCCCGCCCCACAGATGTATTTATTGTACAAACCATGTGAGCCCGGCCGGCCCAGCCAGGCCATCTCACGTGTACA
TAATCAGAGCCACAATAAATTCTATTTCAAGAAAATCCTGCTTGACAAAAACCGTCACTTAGGAAAAGATGTCCTTTCGGGCAGCCAGGC
TCAGCATGAGGAACAGAAGGAATGACACTCTGGACAGCACCCGGACCCTGTACTCCAGCGCGTCTCGGAGCACAGACTTGTCTTACAGTG
AAAGCGACTTGGTGAATTTTATTCAAGCAAATTTTAAGAAACGAGAATGTGTCTTCTTTACCAAAGATTCCAAGGCCACGGAGAATGTGT
GCAAGTGTGGCTATGCCCAGAGCCAGCACATGGAAGGCACCCAGATCAACCAAAGTGAGAAATGGAACTACAAGAAACACACCAAGGAAT
TTCCTACCGACGCCTTTGGGGATATTCAGTTTGAGACACTGGGGAAGAAAGGGAAGTATATACGTCTGTCCTGCGACACGGACGCGGAAA
TCCTTTACGAGCTGCTGACCCAGCACTGGCACCTGAAAACACCCAACCTGGTCATTTCTGTGACCGGGGGCGCCAAGAACTTCGCCCTGA
AGCCGCGCATGCGCAAGATCTTCAGCCGGCTCATCTACATCGCGCAGTCCAAAGGTGCTTGGATTCTCACGGGAGGCACCCATTATGGCC
TGATGAAGTACATCGGGGAGGTGGTGAGAGATAACACCATCAGCAGGAGTTCAGAGGAGAATATTGTGGCCATTGGCATAGCAGCTTGGG
GCATGGTCTCCAACCGGGACACCCTCATCAGGAATTGCGATGCTGAGGGCTATTTTTTAGCCCAGTACCTTATGGATGACTTCACAAGAG
ATCCACTGTATATCCTGGACAACAACCACACACATTTGCTGCTCGTGGACAATGGCTGTCATGGACATCCCACTGTCGAAGCAAAGCTCC
GGAATCAGCTAGAGAAGTATATCTCTGAGCGCACTATTCAAGATTCCAACTATGGTGGCAAGATCCCCATTGTGTGTTTTGCCCAAGGAG
GTGGAAAAGAGACTTTGAAAGCCATCAATACCTCCATCAAAAATAAAATTCCTTGTGTGGTGGTGGAAGGCTCGGGCCAGATCGCTGATG
TGATCGCTAGCCTGGTGGAGGTGGAGGATGCCCTGACATCTTCTGCCGTCAAGGAGAAGCTGGTGCGCTTTTTACCCCGCACGGTGTCCC
GGCTGCCTGAGGAGGAGACTGAGAGTTGGATCAAATGGCTCAAAGAAATTCTCGAATGTTCTCACCTATTAACAGTTATTAAAATGGAAG
AAGCTGGGGATGAAATTGTGAGCAATGCCATCTCCTACGCTCTATACAAAGCCTTCAGCACCAGTGAGCAAGACAAGGATAACTGGAATG
GGCAGCTGAAGCTTCTGCTGGAGTGGAACCAGCTGGACTTAGCCAATGATGAGATTTTCACCAATGACCGCCGATGGGAGTCTGCTGACC
TTCAAGAAGTCATGTTTACGGCTCTCATAAAGGACAGACCCAAGTTTGTCCGCCTCTTTCTGGAGAATGGCTTGAACCTACGGAAGTTTC
TCACCCATGATGTCCTCACTGAACTCTTCTCCAACCACTTCAGCACGCTTGTGTACCGGAATCTGCAGATCGCCAAGAATTCCTATAATG
ATGCCCTCCTCACGTTTGTCTGGAAACTGGTTGCGAACTTCCGAAGAGGCTTCCGGAAGGAAGACAGAAATGGCCGGGACGAGATGGACA
TAGAACTCCACGACGTGTCTCCTATTACTCGGCACCCCCTGCAAGCTCTCTTCATCTGGGCCATTCTTCAGAATAAGAAGGAACTCTCCA
AAGTCATTTGGGAGCAGACCAGGGGCTGCACTCTGGCAGCCCTGGGAGCCAGCAAGCTTCTGAAGACTCTGGCCAAAGTGAAGAACGACA
TCAATGCTGCTGGGGAGTCCGAGGAGCTGGCTAATGAGTACGAGACCCGGGCTGTTGAGCTGTTCACTGAGTGTTACAGCAGCGATGAAG
ACTTGGCAGAACAGCTGCTGGTCTATTCCTGTGAAGCTTGGGGTGGAAGCAACTGTCTGGAGCTGGCGGTGGAGGCCACAGACCAGCATT
TCATCGCCCAGCCTGGGGTCCAGAATTTTCTTTCTAAGCAATGGTATGGAGAGATTTCCCGAGACACCAAGAACTGGAAGATTATCCTGT
GTCTGTTTATTATACCCTTGGTGGGCTGTGGCTTTGTATCATTTAGGAAGAAACCTGTCGACAAGCACAAGAAGCTGCTTTGGTACTATG
TGGCGTTCTTCACCTCCCCCTTCGTGGTCTTCTCCTGGAATGTGGTCTTCTACATCGCCTTCCTCCTGCTGTTTGCCTACGTGCTGCTCA
TGGATTTCCATTCGGTGCCACACCCCCCCGAGCTGGTCCTGTACTCGCTGGTCTTTGTCCTCTTCTGTGATGAAGTGAGACAGTGGTACG
TAAATGGGGTGAATTATTTTACTGACCTGTGGAATGTGATGGACACGCTGGGGCTTTTTTACTTCATAGCAGGAATTGTATTTCGGCTCC
ACTCTTCTAATAAAAGCTCTTTGTATTCTGGACGAGTCATTTTCTGTCTGGACTACATTATTTTCACTCTAAGATTGATCCACATTTTTA
CTGTAAGCAGAAACTTAGGACCCAAGATTATAATGCTGCAGAGGATGCTGATCGATGTGTTCTTCTTCCTGTTCCTCTTTGCGGTGTGGA
TGGTGGCCTTTGGCGTGGCCAGGCAAGGGATCCTTAGGCAGAATGAGCAGCGCTGGAGGTGGATATTCCGTTCGGTCATCTACGAGCCCT
ACCTGGCCATGTTCGGCCAGGTGCCCAGTGACGTGGATGGTACCACGTATGACTTTGCCCACTGCACCTTCACTGGGAATGAGTCCAAGC
CACTGTGTGTGGAGCTGGATGAGCACAACCTGCCCCGGTTCCCCGAGTGGATCACCATCCCCCTGGTGTGCATCTACATGTTATCCACCA
ACATCCTGCTGGTCAACCTGCTGGTCGCCATGTTTGGCTACACGGTGGGCACCGTCCAGGAGAACAATGACCAGGTCTGGAAGTTCCAGA
GGTACTTCCTGGTGCAGGAGTACTGCAGCCGCCTCAATATCCCCTTCCCCTTCATCGTCTTCGCTTACTTCTACATGGTGGTGAAGAAGT
GCTTCAAGTGTTGCTGCAAGGAGAAAAACATGGAGTCTTCTGTCTGCTGTTTCAAAAATGAAGACAATGAGACTCTGGCATGGGAGGGTG
TCATGAAGGAAAACTACCTTGTCAAGATCAACACAAAAGCCAACGACACCTCAGAGGAAATGAGGCATCGATTTAGACAACTGGATACAA
AGCTTAATGATCTCAAGGGTCTTCTGAAAGAGATTGCTAATAAAATCAAATAAAACTGTATGAACTCTAATGGAGAAAAATCTAATTATA
GCAAGATCATATTAAGGAATGCTGATGAACAATTTTGCTATCGACTACTAAATGAGAGATTTTCAGACCCCTGGGTACATGGTGGATGAT
TTTAAATCACCCTAGTGTGCTGAGACCTTGAGAATAAAGTGTGTGATTGGTTTCATACTTGAAGACGGATATAAAGGAAGAATATTTCCT
TTATGTGTTTCTCCAGAATGGTGCCTGTTTCTCTCTGTGTCTCAATGCCTGGGACTGGAGGTTGATAGTTTAAGTGTGTTCTTACCGCCT
CCTTTTTCCTTTAATCTTATTTTTGATGAACACATATATAGGAGAACATCTATCCTATGAATAAGAACCTGGTCATGCTTTACTCCTGTA
TTGTTATTTTGTTCATTTCCAATTGATTCTCTACTTTTCCCTTTTTTGTATTATGTGACTAATTAGTTGGCATATTGTTAAAAGTCTCTC
AAATTAGGCCAGATTCTAAAACATGCTGCAGCAAGAGGACCCCGCTCTCTTCAGGAAAAGTGTTTTCATTTCTCAGGATGCTTCTTACCT
GTCAGAGGAGGTGACAAGGCAGTCTCTTGCTCTCTTGGACTCACCAGGCTCCTATTGAAGGAACCACCCCCATTCCTAAATATGTGAAAA
GTCGCCCAAAATGCAACCTTGAAAGGCACTACTGACTTTGTTCTTATTGGATACTCCTCTTATTATTTTTCCATTAAAAATAATAGCTGG
CTATTATAGAAAATTTAGACCATACAGAGATGTAGAAAGAACATAAATTGTCCCCATTACCTTAAGGTAATCACTGCTAACAATTTCTGG
ATGGTTTTTCAAGTCTATTTTTTTTCTATGTATGTCTCAATTCTCTTTCAAAATTTTACAGAATGTTATCATACTACATATATACTTTTT
ATGTAAGCTTTTTCACTTAGTATTTTATCAAATATGTTTTTATTATATTCATAGCCTTCTTAAACATTATATCAATAATTGCATAATAGG
CAACCTCTAGCGATTACCATAATTTTGCTCATTGAAGGCTATCTCCAGTTGATCATTGGGATGAGCATCTTTGTGCATGAATCCTATTGC
TGTATTTGGGAAAATTTTCCAAGGTTAGATTCCAATAAATATCTATTTATTATTAAATATTAAAATATCTATTTATTATTAAAACCATTT
ATAAGGCTTTTTCATAAATGTATAGCAAATAGGAATTATTAACTTGAGCATAAGATATGAGATACATGAACCTGAACTATTAAAATAAAA
TATTATATTTAACCCTTAGTTTAAGAAGAAGTCAATATGCTTATTTAAATATTATGGATGGTGGGCAGATCACTTGAGGTCAGGAGTTCG
AGACCAGCCTGGCCAACATGGCAAAACCACATCTCTACTAAAAATAAAAAAATTAGCTGGGTGTGGTGGTGCACTCCTGTAATCCCAGCT
ACTCAGAAGGCTGAGGTACAAGAATTGCTGGAACCTGGGAGGCGGAGGTTGCAGTGAACCAAGATTGCACCACTGCACTCCAGCCGGGGT
GACAGAGTGAGACTCCGACTGAAAATAAATAAATAAATAAATAAATAAATAAATAAATATTATGGATGGTGAAGGGAATGGTATAGAATT
GGAGAGATTATCTTACTGAACACCTGTAGTCCCAGCTTTCTCTGGAAGTGGTCGTATTTGAGCAGGATGTGCACAAGGCAATTGAAATGC
CCATAATTAGTTTCTCAGCTTTGAATACACTATAAACTCACTGGCTGAAGGAGGAAATTTTAGAAGGAAGCTACTAAAAGATCTAATTTG
AAAAACTACAAAAGCATTAACTAAAAAAGTTTATTTTCCTTTTGTCTGGGCAGTAGTGAAAATAACTACTCACAACATTCACTATGTTTG
CAAGGAATTAACACAAATAAAAGATGCCTTTTTACTTAAACACCAAGACAGAAAACTTGCCCAATACTGAGAAGCAACTTGCATTAGAGA
GGGAACTGTTAAATGTTTTCAACCCAGTTCATCTGGTGGATGTTTTTGCAGGTTACTCTGAGAATTTTGCTTATGAAAAATCATTATTTT
TAGTGTAGTTCACAATAATGTATTGAACATACTTCTAATCAAAGGTGCTATGTCCTTGTGTATGGTACTAAATGTGTCCTGTGTACTTTT

>In-frame_ENST00000279270_ENST00000324695_TCGA-EJ-7327-01A_SCYL1_chr11_65306175_-_TRPM8_chr2_234826043_length(amino acids)=1104AA_start in transcript=2588_stop in transcript=5902
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN
YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGH
PTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTND
RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFT
ECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENN
DQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SCYL1-TRPM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSCYL1chr11:65306175chr2:234826043ENST00000270176-1818793_808855.0809.0COPB1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000279270-1717793_808835.6666666666666782.0COPB1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000420247-1818793_808838.0792.0COPB1
HgeneSCYL1chr11:65306175chr2:234826043ENST00000533862-1818793_808842.6666666666666788.0COPB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SCYL1-TRPM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SCYL1-TRPM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSCYL1C4225236SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 212GENOMICS_ENGLAND;ORPHANET
TgeneTRPM8C0007852Cervical Migraine Syndrome1CTD_human
TgeneTRPM8C0018984Hemicrania migraine1CTD_human
TgeneTRPM8C0149931Migraine Disorders1CTD_human
TgeneTRPM8C0270858Abdominal Migraine1CTD_human
TgeneTRPM8C0338480Common Migraine1CTD_human
TgeneTRPM8C0338489Status Migrainosus1CTD_human
TgeneTRPM8C0521664Acute Confusional Migraine1CTD_human
TgeneTRPM8C0700438Sick Headaches1CTD_human