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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEC23B-CNGB3 (FusionGDB2 ID:79563)

Fusion Gene Summary for SEC23B-CNGB3

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC23B-CNGB3
Fusion gene ID: 79563
HgeneTgene
Gene symbol

SEC23B

CNGB3

Gene ID

10483

54714

Gene nameSEC23 homolog B, COPII coat complex componentcyclic nucleotide gated channel subunit beta 3
SynonymsCDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23BACHM1
Cytomap

20p11.23

8q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec23BSEC23 homolog B, coat complex II componentSEC23-like protein BSEC23-related protein Btransport protein SEC23Bcyclic nucleotide-gated cation channel beta-3CNG channel beta-3cone photoreceptor cGMP-gated cation channel beta-subunitcyclic nucleotide gated channel beta 3cyclic nucleotide-gated cation channel modulatory subunit
Modification date2020031320200313
UniProtAcc.

Q9NQW8

Ensembl transtripts involved in fusion geneENST00000262544, ENST00000336714, 
ENST00000377475, ENST00000377465, 
ENST00000494645, 		ENST00000320005, 
ENST00000519777, 
Fusion gene scores* DoF score12 X 12 X 9=12963 X 3 X 3=27
# samples 153
** MAII scorelog2(15/1296*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC23B [Title/Abstract] AND CNGB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEC23B(18516386)-CNGB3(87751964), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCNGB3

GO:0006812

cation transport

24164424


check buttonFusion gene breakpoints across SEC23B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CNGB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-A5EL-01ASEC23Bchr20

18516386

-CNGB3chr8

87751964

-


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Fusion Gene ORF analysis for SEC23B-CNGB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262544ENST00000320005SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
5CDS-5UTRENST00000262544ENST00000519777SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
In-frameENST00000336714ENST00000320005SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
5CDS-5UTRENST00000336714ENST00000519777SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
In-frameENST00000377475ENST00000320005SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
5CDS-5UTRENST00000377475ENST00000519777SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
In-frameENST00000377465ENST00000320005SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
5CDS-5UTRENST00000377465ENST00000519777SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
intron-3CDSENST00000494645ENST00000320005SEC23Bchr20

18516386

-CNGB3chr8

87751964

-
intron-5UTRENST00000494645ENST00000519777SEC23Bchr20

18516386

-CNGB3chr8

87751964

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262544SEC23Bchr2018516386-ENST00000320005CNGB3chr887751964-6064189449041941234
ENST00000336714SEC23Bchr2018516386-ENST00000320005CNGB3chr887751964-6006183643241361234
ENST00000377475SEC23Bchr2018516386-ENST00000320005CNGB3chr887751964-6000183042641301234
ENST00000377465SEC23Bchr2018516386-ENST00000320005CNGB3chr887751964-5824165425039541234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262544ENST00000320005SEC23Bchr2018516386-CNGB3chr887751964-0.0003061370.9996939
ENST00000336714ENST00000320005SEC23Bchr2018516386-CNGB3chr887751964-0.0002860260.99971396
ENST00000377475ENST00000320005SEC23Bchr2018516386-CNGB3chr887751964-0.0002945910.9997054
ENST00000377465ENST00000320005SEC23Bchr2018516386-CNGB3chr887751964-0.0002326840.99976736

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Fusion Genomic Features for SEC23B-CNGB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEC23B-CNGB3


check button Go to

FGviewer for the breakpoints of chr20:18516386-chr8:87751964

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CNGB3

Q9NQW8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018532_67643.0810.0Nucleotide binding3'%2C5'-cGMP
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018238_25043.0810.0Topological domainExtracellular
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018272_30243.0810.0Topological domainCytoplasmic
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018324_35943.0810.0Topological domainExtracellular
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018381_41743.0810.0Topological domainCytoplasmic
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018439_50443.0810.0Topological domainExtracellular
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018526_80943.0810.0Topological domainCytoplasmic
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018217_23743.0810.0TransmembraneHelical%3B Name%3DH1
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018251_27143.0810.0TransmembraneHelical%3B Name%3DH2
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018303_32343.0810.0TransmembraneHelical%3B Name%3DH3
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018360_38043.0810.0TransmembraneHelical%3B Name%3DH4
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018418_43843.0810.0TransmembraneHelical%3B Name%3DH5
TgeneCNGB3chr20:18516386chr8:87751964ENST00000320005018505_52543.0810.0TransmembraneHelical%3B Name%3DH6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEC23Bchr20:18516386chr8:87751964ENST00000262544-1220634_720468.0768.0RepeatGelsolin-like
HgeneSEC23Bchr20:18516386chr8:87751964ENST00000336714-1220634_720468.0768.0RepeatGelsolin-like
HgeneSEC23Bchr20:18516386chr8:87751964ENST00000377465-1220634_720468.0768.0RepeatGelsolin-like
HgeneSEC23Bchr20:18516386chr8:87751964ENST00000377475-1220634_720468.0768.0RepeatGelsolin-like
TgeneCNGB3chr20:18516386chr8:87751964ENST000003200050181_21643.0810.0Topological domainCytoplasmic


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Fusion Gene Sequence for SEC23B-CNGB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262544_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(transcript)=6064nt_BP=1894nt
ATCGTTCTCGCTTTCCGGTAGCTAAGGCGATCAGCGGGACTTCCCACTGAGACGAGCGGATGTCATATTGTATCAGGGCGAACCTCTGAG
GAGCGCTGGCTGCGCTTAGGCAACGGTGCGGCAGGCGCCGGGGTTTTCTGAAACAGAAACGTTTAGGGGTGGGGAAACGTGTTCCGAGGA
ACTCTCGTTTTGAAGTGCGACATACACCTGTCTTGCCCTGTTCCAAGATGGTGGCAGAGCTTCTCTGAGTCTCTCGCTTCCTCCAGTCCG
TCGGAGAAGCGCTCTTTGATTGGCCAGTGGACAGCGCCGTGGCATGACGCGCTGGGGCGCTGGCCAATCGGTTGAGAGCTGAGCTGGACT
TGGCGGTGGGAGCCGGAGCCTGCTTGTTGCAGCTGTGGGTGAGGACGGCTCTAGCTAGGTGAGCGGCTCCGGCCAGGTGAGCGGGGCGCA
TAGGTGACGGAGGGCCGAGGGCACGGTTCCCTTTTAGACTATGGCGACATACCTGGAGTTCATCCAGCAGAATGAAGAACGGGATGGTGT
GCGTTTTAGTTGGAACGTGTGGCCTTCCAGCCGGCTGGAGGCTACAAGAATGGTTGTACCCCTGGCTTGTCTCCTTACTCCTTTGAAAGA
ACGTCCAGACCTACCTCCTGTACAATATGAACCTGTGCTTTGCAGCAGGCCAACTTGTAAAGCTGTTCTCAACCCACTTTGTCAGGTTGA
TTATCGAGCAAAACTTTGGGCCTGTAATTTCTGTTTTCAAAGAAATCAGTTTCCTCCAGCTTATGGAGGCATATCTGAGGTGAATCAACC
TGCCGAATTGATGCCCCAGTTTTCTACAATTGAGTACGTGATACAGCGAGGTGCTCAGTCCCCTCTGATCTTTCTCTATGTGGTTGACAC
ATGCCTGGAGGAAGATGACCTTCAAGCACTCAAAGAGTCCCTGCAGATGTCCCTGAGTCTTCTTCCTCCAGATGCTCTGGTGGGTCTGAT
CACATTTGGAAGGATGGTGCAGGTTCATGAGCTAAGCTGTGAAGGAATCTCCAAAAGTTATGTCTTCCGAGGGACCAAGGATTTAACTGC
AAAGCAAATACAGGATATGTTGGGCCTGACCAAGCCAGCCATGCCCATGCAGCAAGCACGACCTGCACAACCACAGGAGCACCCTTTTGC
TTCAAGCAGATTTCTGCAGCCTGTTCACAAGATTGATATGAACCTCACTGATCTTCTTGGGGAGCTACAGAGGGACCCATGGCCAGTAAC
TCAGGGGAAGAGACCTTTGCGATCCACTGGTGTGGCTTTGTCCATTGCTGTTGGCTTGCTGGAGGGCACTTTTCCAAACACAGGAGCCAG
GATCATGCTGTTTACTGGAGGTCCCCCTACCCAAGGGCCTGGCATGGTGGTTGGAGATGAATTAAAGATTCCTATTCGTTCTTGGCATGA
TATTGAGAAAGATAATGCACGATTCATGAAAAAGGCAACCAAGCACTATGAGATGCTTGCTAATCGAACAGCTGCAAATGGTCACTGCAT
TGATATTTATGCTTGTGCCCTTGATCAAACTGGACTTTTGGAGATGAAGTGTTGTGCAAATCTTACTGGAGGCTACATGGTAATGGGAGA
TTCTTTCAACACTTCTCTCTTCAAGCAGACATTCCAAAGAATCTTTACTAAAGATTTTAATGGAGATTTCCGAATGGCATTTGGTGCTAC
TTTGGACGTAAAGACCTCTCGGGAACTGAAGATTGCAGGAGCCATTGGTCCATGCGTATCTCTGAATGTGAAAGGACCGTGTGTGTCAGA
AAATGAGCTTGGTGTTGGTGGCACGAGTCAGTGGAAAATCTGTGGCCTAGATCCTACATCTACACTTGGCATCTATTTTGAAGTTGTCAA
TCAGGAAGAAAACAAAGGTGAAGAGAAATCTCTCAAAACCAAGTCAACTCCAGTCACGTCTGAAGAGCCACACACCAACATACAAGACAA
ACTCTCCAAGAAAAATTCCTCTGGAGATCTGACCACAAACCCTGACCCTCAAAATGCAGCAGAACCAACTGGAACAGTGCCAGAGCAGAA
GGAAATGGACCCCGGGAAAGAAGGTCCAAACAGCCCACAAAACAAACCGCCTGCAGCTCCTGTTATAAATGAGTATGCCGATGCCCAGCT
ACACAACCTGGTGAAAAGAATGCGTCAAAGAACAGCCCTCTACAAGAAAAAGTTGGTAGAGGGAGATCTCTCCTCACCCGAAGCCAGCCC
ACAAACTGCAAAGCCCACGGCTGTACCACCAGTAAAAGAAAGCGATGATAAGCCAACAGAACATTACTACAGGCTGTTGTGGTTCAAAGT
CAAAAAGATGCCTTTAACAGAGTACTTAAAGCGAATTAAACTTCCAAACAGCATAGATTCATACACAGATCGACTCTATCTCCTGTGGCT
CTTGCTTGTCACTCTTGCCTATAACTGGAACTGCTGTTTTATACCACTGCGCCTCGTCTTCCCATATCAAACCGCAGACAACATACACTA
CTGGCTTATTGCGGACATCATATGTGATATCATCTACCTTTATGATATGCTATTTATCCAGCCCAGACTCCAGTTTGTAAGAGGAGGAGA
CATAATAGTGGATTCAAATGAGCTAAGGAAACACTACAGGACTTCTACAAAATTTCAGTTGGATGTCGCATCAATAATACCATTTGATAT
TTGCTACCTCTTCTTTGGGTTTAATCCAATGTTTAGAGCAAATAGGATGTTAAAGTACACTTCATTTTTTGAATTTAATCATCACCTAGA
GTCTATAATGGACAAAGCATATATCTACAGAGTTATTCGAACAACTGGATACTTGCTGTTTATTCTGCACATTAATGCCTGTGTTTATTA
CTGGGCTTCAAACTATGAAGGAATTGGCACTACTAGATGGGTGTATGATGGGGAAGGAAACGAGTATCTGAGATGTTATTATTGGGCAGT
TCGAACTTTAATTACCATTGGTGGCCTTCCAGAACCACAAACTTTATTTGAAATTGTTTTTCAACTCTTGAATTTTTTTTCTGGAGTTTT
TGTGTTCTCCAGTTTAATTGGTCAGATGAGAGATGTGATTGGAGCAGCTACAGCCAATCAGAACTACTTCCGCGCCTGCATGGATGACAC
CATTGCCTACATGAACAATTACTCCATTCCTAAACTTGTGCAAAAGCGAGTTCGGACTTGGTATGAATATACATGGGACTCTCAAAGAAT
GCTAGATGAGTCTGATTTGCTTAAGACCCTACCAACTACGGTCCAGTTAGCCCTCGCCATTGATGTGAACTTCAGCATCATCAGCAAAGT
CGACTTGTTCAAGGGTTGTGATACACAGATGATTTATGACATGTTGCTAAGATTGAAATCCGTTCTCTATTTGCCTGGTGACTTTGTCTG
CAAAAAGGGAGAAATTGGCAAGGAAATGTATATCATCAAGCATGGAGAAGTCCAAGTTCTTGGAGGCCCTGATGGTACTAAAGTTCTGGT
TACTCTGAAAGCTGGGTCGGTGTTTGGAGAAATCAGCCTTCTAGCAGCAGGAGGAGGAAACCGTCGAACTGCCAATGTGGTGGCCCACGG
GTTTGCCAATCTTTTAACTCTAGACAAAAAGACCCTCCAAGAAATTCTAGTGCATTATCCAGATTCTGAAAGGATCCTCATGAAGAAAGC
CAGAGTGCTTTTAAAGCAGAAGGCTAAGACCGCAGAAGCAACCCCTCCAAGAAAAGATCTTGCCCTCCTCTTCCCACCGAAAGAAGAGAC
ACCCAAACTGTTTAAAACTCTCCTAGGAGGCACAGGAAAAGCAAGTCTTGCAAGACTACTCAAATTGAAGCGAGAGCAAGCAGCTCAGAA
GAAAGAAAATTCTGAAGGAGGAGAGGAAGAAGGAAAAGAAAATGAAGATAAACAAAAAGAAAATGAAGATAAACAAAAAGAAAATGAAGA
TAAAGGAAAAGAAAATGAAGATAAAGATAAAGGAAGAGAGCCAGAAGAGAAGCCACTGGACAGACCTGAATGTACAGCAAGTCCTATTGC
AGTGGAGGAAGAACCCCACTCAGTTAGAAGGACAGTTTTACCCAGAGGGACTTCTCGTCAATCACTCATTATCAGCATGGCTCCTTCTGC
TGAGGGCGGAGAAGAGGTTCTTACTATTGAAGTCAAAGAAAAGGCTAAGCAATAAATGTTTGATTATCTTTAGATGTGATATAGCTAGTT
CCCAAAGTGATTGTACCTAGGATTGTAACTTAAATTAACGAGGGGAAACGACATGCTGGGACCCTTGAGAAACGAAAGGCAAATCCCTAG
CTTAGTTTCTAGGACTTATCTGAGAGTGTGATTTCATGCAGTGGTAATAAGAAGATTATTAAAAGCCATCCCTATTCTCCGTTTTCATTA
ACTTTATGCAATTGCTATATCTTCTAATTGTATGTAGTAAGTTTCCTTTTCCTTTGGTTCTTTCCTGATGATGTCTCTTCCTTCCAGTTT
TATTAGCTTGCTCTTGGCTGTGATGTGATTCACTAACCTTTTCTCTTAATTTTTATTGTGTTTAATTTCTTCTTTGGCACTCTAAAGCCT
GGCTAATTGTTCTAGGTTTATGAATTTCACCTCTTACATGTAAAGGGTATAAGATTTTAATGTAATAGGTCAAAAATCAGATTATTTTCA
TTCAAATGAGGATGATGAGTCACTGTAATATCAAAAAATCCCCAGCAGCTGGGACTGAAGGGAAGCAGAGATCATGAAGCTTTCTGAATG
AGAAGTCTGATTTTTGGAACAGTCCCCTGAAGACCAATGTTGGTCGGCAGAATTAGCAAACTGGCAAAATCACATTGCAGGAACATATTG
GAAAAATTGTACCCTTTACTAAAGAAATAAACTTCAATATTTTCTCTTCTAACCAACTTAAAAGACACCAATCTACCTAACTCATCTGGC
TCAAGGGACTTGGACTGGAGGATACAGGCTAAAGTGACACTTATCAGAATCTTCCTCAAGCACTTGCTGGAAAAGATATCAGATTGGAAC
TTCTTGTTTAAAATTAAGCTTTAGTAAAACAAAGTGATGAGGTTAGGAAGGCAGACTCTACACATGTCAGATTGACATATCCCCACAATT
TCCGGAACCTACATGTATAGCTGTTTACAAAATCTCCAAGTTAATTAAGGGCACTTTAGGAAGTTGTCCTCATGAATTAGCTAGCATTAG
CATAATTACCGACGTTGCATGCTGTGAGGAGGCTACAAAGGCCAGGCTGGTGTCGGAAGTAATAATACATATAGAATTCCATTCTAATAA
ATGCCATTAGTGTATAACATCAAGTTCTGTGTAATGAGGCTATTTCCAAGTCTCCAAAGATGGTCACTGTAACAGCACTTTGCTGAGAGG
GTTTTAACAAATCATATTAGCCAAAAAGCCTACAACATAGATGCATTTAGCAAACCATGTACAAATCAATCACTATAATAAACTGCATCA
TTTGATAGAGTCACCGTTTTTGCATGTAGTGTTAGAGTATCACAAAATATAACAAGTTTTACTAAAGGATGGTTGGTTTTTTCAGGATTT
AAGGGAATATGGACAAATTGTTAAATAGTATTTATTTGATAAATGGGAGTTTGTATGCAGAAAGAGTGAATTGCGTATAAAAAGGGTGAT
TTAAAAACCCAGAAACAAAAGGTAGAATAGGGCTGAAGCATCTGATAATAGGAAAAGAAAAGGACAAAAGTCCTCAACTTGTGAGCAATA
TGCTTTCCCTTTACACCCTGTAATTTATTCAAATGATATTAAAATACAAGACCATTGCAATTTATGCTTTTCGCCTGGCAGTTATTTTCC
CCCCCAAGCTATCCTGTTTCAGATAATATCAATTTATTTCCAATCCATCAGACTAAAATCTAAGAAAATTCAAGAACTCTTTTATTGTTG
ATTTGGTGCCACCAAATTCTTTTTCTTTTTAAATCTTTCTAATTATCCTTTCTTTTTCAATCCCATTGCTAACACCCAGAACATATTTTC

>In-frame_ENST00000262544_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(amino acids)=1234AA_start in transcript=490_stop in transcript=4194
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLL
EMKCCANLTGGYMVMGDSFNTSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
CGLDPTSTLGIYFEVVNQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQ
NKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIK
LPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYR
TSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRW
VYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLV
QKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIK
HGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEA
TPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGRE

--------------------------------------------------------------
>In-frame_ENST00000336714_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(transcript)=6006nt_BP=1836nt
ATCGTTCTCGCTTTCCGGTAGCTAAGGCGATCAGCGGGACTTCCCACTGAGACGAGCGGATGTCATATTGTATCAGGGCGAACCTCTGAG
GAGCGCTGGCTGCGCTTAGGCAACGGTGCGGCAGGCGCCGGGGTTTTCTGAAACAGAAACGTTTAGGGGTGGGGAAACGTGTTCCGAGGA
ACTCTCGTTTTGAAGTGCGACATACACCTGTCTTGCCCTGTTCCAAGATGGTGGCAGAGCTTCTCTGAGTCTCTCGCTTCCTCCAGTCCG
TCGGAGAAGCGCTCTTTGATTGGCCAGTGGACAGCGCCGTGGCATGACGCGCTGGGGCGCTGGCCAATCGGTTGAGAGCTGAGCTGGACT
TGGCGGTGGGAGCCGGAGCCTGCTTGTTGCAGCTGTGGGTGAGGACGGCTCTAGCTAGTTCCCTTTTAGACTATGGCGACATACCTGGAG
TTCATCCAGCAGAATGAAGAACGGGATGGTGTGCGTTTTAGTTGGAACGTGTGGCCTTCCAGCCGGCTGGAGGCTACAAGAATGGTTGTA
CCCCTGGCTTGTCTCCTTACTCCTTTGAAAGAACGTCCAGACCTACCTCCTGTACAATATGAACCTGTGCTTTGCAGCAGGCCAACTTGT
AAAGCTGTTCTCAACCCACTTTGTCAGGTTGATTATCGAGCAAAACTTTGGGCCTGTAATTTCTGTTTTCAAAGAAATCAGTTTCCTCCA
GCTTATGGAGGCATATCTGAGGTGAATCAACCTGCCGAATTGATGCCCCAGTTTTCTACAATTGAGTACGTGATACAGCGAGGTGCTCAG
TCCCCTCTGATCTTTCTCTATGTGGTTGACACATGCCTGGAGGAAGATGACCTTCAAGCACTCAAAGAGTCCCTGCAGATGTCCCTGAGT
CTTCTTCCTCCAGATGCTCTGGTGGGTCTGATCACATTTGGAAGGATGGTGCAGGTTCATGAGCTAAGCTGTGAAGGAATCTCCAAAAGT
TATGTCTTCCGAGGGACCAAGGATTTAACTGCAAAGCAAATACAGGATATGTTGGGCCTGACCAAGCCAGCCATGCCCATGCAGCAAGCA
CGACCTGCACAACCACAGGAGCACCCTTTTGCTTCAAGCAGATTTCTGCAGCCTGTTCACAAGATTGATATGAACCTCACTGATCTTCTT
GGGGAGCTACAGAGGGACCCATGGCCAGTAACTCAGGGGAAGAGACCTTTGCGATCCACTGGTGTGGCTTTGTCCATTGCTGTTGGCTTG
CTGGAGGGCACTTTTCCAAACACAGGAGCCAGGATCATGCTGTTTACTGGAGGTCCCCCTACCCAAGGGCCTGGCATGGTGGTTGGAGAT
GAATTAAAGATTCCTATTCGTTCTTGGCATGATATTGAGAAAGATAATGCACGATTCATGAAAAAGGCAACCAAGCACTATGAGATGCTT
GCTAATCGAACAGCTGCAAATGGTCACTGCATTGATATTTATGCTTGTGCCCTTGATCAAACTGGACTTTTGGAGATGAAGTGTTGTGCA
AATCTTACTGGAGGCTACATGGTAATGGGAGATTCTTTCAACACTTCTCTCTTCAAGCAGACATTCCAAAGAATCTTTACTAAAGATTTT
AATGGAGATTTCCGAATGGCATTTGGTGCTACTTTGGACGTAAAGACCTCTCGGGAACTGAAGATTGCAGGAGCCATTGGTCCATGCGTA
TCTCTGAATGTGAAAGGACCGTGTGTGTCAGAAAATGAGCTTGGTGTTGGTGGCACGAGTCAGTGGAAAATCTGTGGCCTAGATCCTACA
TCTACACTTGGCATCTATTTTGAAGTTGTCAATCAGGAAGAAAACAAAGGTGAAGAGAAATCTCTCAAAACCAAGTCAACTCCAGTCACG
TCTGAAGAGCCACACACCAACATACAAGACAAACTCTCCAAGAAAAATTCCTCTGGAGATCTGACCACAAACCCTGACCCTCAAAATGCA
GCAGAACCAACTGGAACAGTGCCAGAGCAGAAGGAAATGGACCCCGGGAAAGAAGGTCCAAACAGCCCACAAAACAAACCGCCTGCAGCT
CCTGTTATAAATGAGTATGCCGATGCCCAGCTACACAACCTGGTGAAAAGAATGCGTCAAAGAACAGCCCTCTACAAGAAAAAGTTGGTA
GAGGGAGATCTCTCCTCACCCGAAGCCAGCCCACAAACTGCAAAGCCCACGGCTGTACCACCAGTAAAAGAAAGCGATGATAAGCCAACA
GAACATTACTACAGGCTGTTGTGGTTCAAAGTCAAAAAGATGCCTTTAACAGAGTACTTAAAGCGAATTAAACTTCCAAACAGCATAGAT
TCATACACAGATCGACTCTATCTCCTGTGGCTCTTGCTTGTCACTCTTGCCTATAACTGGAACTGCTGTTTTATACCACTGCGCCTCGTC
TTCCCATATCAAACCGCAGACAACATACACTACTGGCTTATTGCGGACATCATATGTGATATCATCTACCTTTATGATATGCTATTTATC
CAGCCCAGACTCCAGTTTGTAAGAGGAGGAGACATAATAGTGGATTCAAATGAGCTAAGGAAACACTACAGGACTTCTACAAAATTTCAG
TTGGATGTCGCATCAATAATACCATTTGATATTTGCTACCTCTTCTTTGGGTTTAATCCAATGTTTAGAGCAAATAGGATGTTAAAGTAC
ACTTCATTTTTTGAATTTAATCATCACCTAGAGTCTATAATGGACAAAGCATATATCTACAGAGTTATTCGAACAACTGGATACTTGCTG
TTTATTCTGCACATTAATGCCTGTGTTTATTACTGGGCTTCAAACTATGAAGGAATTGGCACTACTAGATGGGTGTATGATGGGGAAGGA
AACGAGTATCTGAGATGTTATTATTGGGCAGTTCGAACTTTAATTACCATTGGTGGCCTTCCAGAACCACAAACTTTATTTGAAATTGTT
TTTCAACTCTTGAATTTTTTTTCTGGAGTTTTTGTGTTCTCCAGTTTAATTGGTCAGATGAGAGATGTGATTGGAGCAGCTACAGCCAAT
CAGAACTACTTCCGCGCCTGCATGGATGACACCATTGCCTACATGAACAATTACTCCATTCCTAAACTTGTGCAAAAGCGAGTTCGGACT
TGGTATGAATATACATGGGACTCTCAAAGAATGCTAGATGAGTCTGATTTGCTTAAGACCCTACCAACTACGGTCCAGTTAGCCCTCGCC
ATTGATGTGAACTTCAGCATCATCAGCAAAGTCGACTTGTTCAAGGGTTGTGATACACAGATGATTTATGACATGTTGCTAAGATTGAAA
TCCGTTCTCTATTTGCCTGGTGACTTTGTCTGCAAAAAGGGAGAAATTGGCAAGGAAATGTATATCATCAAGCATGGAGAAGTCCAAGTT
CTTGGAGGCCCTGATGGTACTAAAGTTCTGGTTACTCTGAAAGCTGGGTCGGTGTTTGGAGAAATCAGCCTTCTAGCAGCAGGAGGAGGA
AACCGTCGAACTGCCAATGTGGTGGCCCACGGGTTTGCCAATCTTTTAACTCTAGACAAAAAGACCCTCCAAGAAATTCTAGTGCATTAT
CCAGATTCTGAAAGGATCCTCATGAAGAAAGCCAGAGTGCTTTTAAAGCAGAAGGCTAAGACCGCAGAAGCAACCCCTCCAAGAAAAGAT
CTTGCCCTCCTCTTCCCACCGAAAGAAGAGACACCCAAACTGTTTAAAACTCTCCTAGGAGGCACAGGAAAAGCAAGTCTTGCAAGACTA
CTCAAATTGAAGCGAGAGCAAGCAGCTCAGAAGAAAGAAAATTCTGAAGGAGGAGAGGAAGAAGGAAAAGAAAATGAAGATAAACAAAAA
GAAAATGAAGATAAACAAAAAGAAAATGAAGATAAAGGAAAAGAAAATGAAGATAAAGATAAAGGAAGAGAGCCAGAAGAGAAGCCACTG
GACAGACCTGAATGTACAGCAAGTCCTATTGCAGTGGAGGAAGAACCCCACTCAGTTAGAAGGACAGTTTTACCCAGAGGGACTTCTCGT
CAATCACTCATTATCAGCATGGCTCCTTCTGCTGAGGGCGGAGAAGAGGTTCTTACTATTGAAGTCAAAGAAAAGGCTAAGCAATAAATG
TTTGATTATCTTTAGATGTGATATAGCTAGTTCCCAAAGTGATTGTACCTAGGATTGTAACTTAAATTAACGAGGGGAAACGACATGCTG
GGACCCTTGAGAAACGAAAGGCAAATCCCTAGCTTAGTTTCTAGGACTTATCTGAGAGTGTGATTTCATGCAGTGGTAATAAGAAGATTA
TTAAAAGCCATCCCTATTCTCCGTTTTCATTAACTTTATGCAATTGCTATATCTTCTAATTGTATGTAGTAAGTTTCCTTTTCCTTTGGT
TCTTTCCTGATGATGTCTCTTCCTTCCAGTTTTATTAGCTTGCTCTTGGCTGTGATGTGATTCACTAACCTTTTCTCTTAATTTTTATTG
TGTTTAATTTCTTCTTTGGCACTCTAAAGCCTGGCTAATTGTTCTAGGTTTATGAATTTCACCTCTTACATGTAAAGGGTATAAGATTTT
AATGTAATAGGTCAAAAATCAGATTATTTTCATTCAAATGAGGATGATGAGTCACTGTAATATCAAAAAATCCCCAGCAGCTGGGACTGA
AGGGAAGCAGAGATCATGAAGCTTTCTGAATGAGAAGTCTGATTTTTGGAACAGTCCCCTGAAGACCAATGTTGGTCGGCAGAATTAGCA
AACTGGCAAAATCACATTGCAGGAACATATTGGAAAAATTGTACCCTTTACTAAAGAAATAAACTTCAATATTTTCTCTTCTAACCAACT
TAAAAGACACCAATCTACCTAACTCATCTGGCTCAAGGGACTTGGACTGGAGGATACAGGCTAAAGTGACACTTATCAGAATCTTCCTCA
AGCACTTGCTGGAAAAGATATCAGATTGGAACTTCTTGTTTAAAATTAAGCTTTAGTAAAACAAAGTGATGAGGTTAGGAAGGCAGACTC
TACACATGTCAGATTGACATATCCCCACAATTTCCGGAACCTACATGTATAGCTGTTTACAAAATCTCCAAGTTAATTAAGGGCACTTTA
GGAAGTTGTCCTCATGAATTAGCTAGCATTAGCATAATTACCGACGTTGCATGCTGTGAGGAGGCTACAAAGGCCAGGCTGGTGTCGGAA
GTAATAATACATATAGAATTCCATTCTAATAAATGCCATTAGTGTATAACATCAAGTTCTGTGTAATGAGGCTATTTCCAAGTCTCCAAA
GATGGTCACTGTAACAGCACTTTGCTGAGAGGGTTTTAACAAATCATATTAGCCAAAAAGCCTACAACATAGATGCATTTAGCAAACCAT
GTACAAATCAATCACTATAATAAACTGCATCATTTGATAGAGTCACCGTTTTTGCATGTAGTGTTAGAGTATCACAAAATATAACAAGTT
TTACTAAAGGATGGTTGGTTTTTTCAGGATTTAAGGGAATATGGACAAATTGTTAAATAGTATTTATTTGATAAATGGGAGTTTGTATGC
AGAAAGAGTGAATTGCGTATAAAAAGGGTGATTTAAAAACCCAGAAACAAAAGGTAGAATAGGGCTGAAGCATCTGATAATAGGAAAAGA
AAAGGACAAAAGTCCTCAACTTGTGAGCAATATGCTTTCCCTTTACACCCTGTAATTTATTCAAATGATATTAAAATACAAGACCATTGC
AATTTATGCTTTTCGCCTGGCAGTTATTTTCCCCCCCAAGCTATCCTGTTTCAGATAATATCAATTTATTTCCAATCCATCAGACTAAAA
TCTAAGAAAATTCAAGAACTCTTTTATTGTTGATTTGGTGCCACCAAATTCTTTTTCTTTTTAAATCTTTCTAATTATCCTTTCTTTTTC

>In-frame_ENST00000336714_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(amino acids)=1234AA_start in transcript=432_stop in transcript=4136
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLL
EMKCCANLTGGYMVMGDSFNTSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
CGLDPTSTLGIYFEVVNQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQ
NKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIK
LPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYR
TSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRW
VYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLV
QKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIK
HGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEA
TPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGRE

--------------------------------------------------------------
>In-frame_ENST00000377475_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(transcript)=6000nt_BP=1830nt
AGGCGATCAGCGGGACTTCCCACTGAGACGAGCGGATGTCATATTGTATCAGGGCGAACCTCTGAGGAGCGCTGGCTGCGCTTAGGCAAC
GGTGCGGCAGGCGCCGGGGTTTTCTGAAACAGAAACGTTTAGGGGTGGGGAAACGTGTTCCGAGGAACTCTCGTTTTGAAGTGCGACATA
CACCTGTCTTGCCCTGTTCCAAGATGGTGGCAGAGCTTCTCTGAGTCTCTCGCTTCCTCCAGTCCGTCGGAGAAGCGCTCTTTGATTGGC
CAGTGGACAGCGCCGTGGCATGACGCGCTGGGGCGCTGGCCAATCGGTTGAGAGCTGAGCTGGACTTGGCGGTGGGAGCCGGAGCCTGCT
TGTTGCAGCTGTGGGTGAGGACGGCTCTAGCTAGGTGAGCGGCTCCGGCCAGTTCCCTTTTAGACTATGGCGACATACCTGGAGTTCATC
CAGCAGAATGAAGAACGGGATGGTGTGCGTTTTAGTTGGAACGTGTGGCCTTCCAGCCGGCTGGAGGCTACAAGAATGGTTGTACCCCTG
GCTTGTCTCCTTACTCCTTTGAAAGAACGTCCAGACCTACCTCCTGTACAATATGAACCTGTGCTTTGCAGCAGGCCAACTTGTAAAGCT
GTTCTCAACCCACTTTGTCAGGTTGATTATCGAGCAAAACTTTGGGCCTGTAATTTCTGTTTTCAAAGAAATCAGTTTCCTCCAGCTTAT
GGAGGCATATCTGAGGTGAATCAACCTGCCGAATTGATGCCCCAGTTTTCTACAATTGAGTACGTGATACAGCGAGGTGCTCAGTCCCCT
CTGATCTTTCTCTATGTGGTTGACACATGCCTGGAGGAAGATGACCTTCAAGCACTCAAAGAGTCCCTGCAGATGTCCCTGAGTCTTCTT
CCTCCAGATGCTCTGGTGGGTCTGATCACATTTGGAAGGATGGTGCAGGTTCATGAGCTAAGCTGTGAAGGAATCTCCAAAAGTTATGTC
TTCCGAGGGACCAAGGATTTAACTGCAAAGCAAATACAGGATATGTTGGGCCTGACCAAGCCAGCCATGCCCATGCAGCAAGCACGACCT
GCACAACCACAGGAGCACCCTTTTGCTTCAAGCAGATTTCTGCAGCCTGTTCACAAGATTGATATGAACCTCACTGATCTTCTTGGGGAG
CTACAGAGGGACCCATGGCCAGTAACTCAGGGGAAGAGACCTTTGCGATCCACTGGTGTGGCTTTGTCCATTGCTGTTGGCTTGCTGGAG
GGCACTTTTCCAAACACAGGAGCCAGGATCATGCTGTTTACTGGAGGTCCCCCTACCCAAGGGCCTGGCATGGTGGTTGGAGATGAATTA
AAGATTCCTATTCGTTCTTGGCATGATATTGAGAAAGATAATGCACGATTCATGAAAAAGGCAACCAAGCACTATGAGATGCTTGCTAAT
CGAACAGCTGCAAATGGTCACTGCATTGATATTTATGCTTGTGCCCTTGATCAAACTGGACTTTTGGAGATGAAGTGTTGTGCAAATCTT
ACTGGAGGCTACATGGTAATGGGAGATTCTTTCAACACTTCTCTCTTCAAGCAGACATTCCAAAGAATCTTTACTAAAGATTTTAATGGA
GATTTCCGAATGGCATTTGGTGCTACTTTGGACGTAAAGACCTCTCGGGAACTGAAGATTGCAGGAGCCATTGGTCCATGCGTATCTCTG
AATGTGAAAGGACCGTGTGTGTCAGAAAATGAGCTTGGTGTTGGTGGCACGAGTCAGTGGAAAATCTGTGGCCTAGATCCTACATCTACA
CTTGGCATCTATTTTGAAGTTGTCAATCAGGAAGAAAACAAAGGTGAAGAGAAATCTCTCAAAACCAAGTCAACTCCAGTCACGTCTGAA
GAGCCACACACCAACATACAAGACAAACTCTCCAAGAAAAATTCCTCTGGAGATCTGACCACAAACCCTGACCCTCAAAATGCAGCAGAA
CCAACTGGAACAGTGCCAGAGCAGAAGGAAATGGACCCCGGGAAAGAAGGTCCAAACAGCCCACAAAACAAACCGCCTGCAGCTCCTGTT
ATAAATGAGTATGCCGATGCCCAGCTACACAACCTGGTGAAAAGAATGCGTCAAAGAACAGCCCTCTACAAGAAAAAGTTGGTAGAGGGA
GATCTCTCCTCACCCGAAGCCAGCCCACAAACTGCAAAGCCCACGGCTGTACCACCAGTAAAAGAAAGCGATGATAAGCCAACAGAACAT
TACTACAGGCTGTTGTGGTTCAAAGTCAAAAAGATGCCTTTAACAGAGTACTTAAAGCGAATTAAACTTCCAAACAGCATAGATTCATAC
ACAGATCGACTCTATCTCCTGTGGCTCTTGCTTGTCACTCTTGCCTATAACTGGAACTGCTGTTTTATACCACTGCGCCTCGTCTTCCCA
TATCAAACCGCAGACAACATACACTACTGGCTTATTGCGGACATCATATGTGATATCATCTACCTTTATGATATGCTATTTATCCAGCCC
AGACTCCAGTTTGTAAGAGGAGGAGACATAATAGTGGATTCAAATGAGCTAAGGAAACACTACAGGACTTCTACAAAATTTCAGTTGGAT
GTCGCATCAATAATACCATTTGATATTTGCTACCTCTTCTTTGGGTTTAATCCAATGTTTAGAGCAAATAGGATGTTAAAGTACACTTCA
TTTTTTGAATTTAATCATCACCTAGAGTCTATAATGGACAAAGCATATATCTACAGAGTTATTCGAACAACTGGATACTTGCTGTTTATT
CTGCACATTAATGCCTGTGTTTATTACTGGGCTTCAAACTATGAAGGAATTGGCACTACTAGATGGGTGTATGATGGGGAAGGAAACGAG
TATCTGAGATGTTATTATTGGGCAGTTCGAACTTTAATTACCATTGGTGGCCTTCCAGAACCACAAACTTTATTTGAAATTGTTTTTCAA
CTCTTGAATTTTTTTTCTGGAGTTTTTGTGTTCTCCAGTTTAATTGGTCAGATGAGAGATGTGATTGGAGCAGCTACAGCCAATCAGAAC
TACTTCCGCGCCTGCATGGATGACACCATTGCCTACATGAACAATTACTCCATTCCTAAACTTGTGCAAAAGCGAGTTCGGACTTGGTAT
GAATATACATGGGACTCTCAAAGAATGCTAGATGAGTCTGATTTGCTTAAGACCCTACCAACTACGGTCCAGTTAGCCCTCGCCATTGAT
GTGAACTTCAGCATCATCAGCAAAGTCGACTTGTTCAAGGGTTGTGATACACAGATGATTTATGACATGTTGCTAAGATTGAAATCCGTT
CTCTATTTGCCTGGTGACTTTGTCTGCAAAAAGGGAGAAATTGGCAAGGAAATGTATATCATCAAGCATGGAGAAGTCCAAGTTCTTGGA
GGCCCTGATGGTACTAAAGTTCTGGTTACTCTGAAAGCTGGGTCGGTGTTTGGAGAAATCAGCCTTCTAGCAGCAGGAGGAGGAAACCGT
CGAACTGCCAATGTGGTGGCCCACGGGTTTGCCAATCTTTTAACTCTAGACAAAAAGACCCTCCAAGAAATTCTAGTGCATTATCCAGAT
TCTGAAAGGATCCTCATGAAGAAAGCCAGAGTGCTTTTAAAGCAGAAGGCTAAGACCGCAGAAGCAACCCCTCCAAGAAAAGATCTTGCC
CTCCTCTTCCCACCGAAAGAAGAGACACCCAAACTGTTTAAAACTCTCCTAGGAGGCACAGGAAAAGCAAGTCTTGCAAGACTACTCAAA
TTGAAGCGAGAGCAAGCAGCTCAGAAGAAAGAAAATTCTGAAGGAGGAGAGGAAGAAGGAAAAGAAAATGAAGATAAACAAAAAGAAAAT
GAAGATAAACAAAAAGAAAATGAAGATAAAGGAAAAGAAAATGAAGATAAAGATAAAGGAAGAGAGCCAGAAGAGAAGCCACTGGACAGA
CCTGAATGTACAGCAAGTCCTATTGCAGTGGAGGAAGAACCCCACTCAGTTAGAAGGACAGTTTTACCCAGAGGGACTTCTCGTCAATCA
CTCATTATCAGCATGGCTCCTTCTGCTGAGGGCGGAGAAGAGGTTCTTACTATTGAAGTCAAAGAAAAGGCTAAGCAATAAATGTTTGAT
TATCTTTAGATGTGATATAGCTAGTTCCCAAAGTGATTGTACCTAGGATTGTAACTTAAATTAACGAGGGGAAACGACATGCTGGGACCC
TTGAGAAACGAAAGGCAAATCCCTAGCTTAGTTTCTAGGACTTATCTGAGAGTGTGATTTCATGCAGTGGTAATAAGAAGATTATTAAAA
GCCATCCCTATTCTCCGTTTTCATTAACTTTATGCAATTGCTATATCTTCTAATTGTATGTAGTAAGTTTCCTTTTCCTTTGGTTCTTTC
CTGATGATGTCTCTTCCTTCCAGTTTTATTAGCTTGCTCTTGGCTGTGATGTGATTCACTAACCTTTTCTCTTAATTTTTATTGTGTTTA
ATTTCTTCTTTGGCACTCTAAAGCCTGGCTAATTGTTCTAGGTTTATGAATTTCACCTCTTACATGTAAAGGGTATAAGATTTTAATGTA
ATAGGTCAAAAATCAGATTATTTTCATTCAAATGAGGATGATGAGTCACTGTAATATCAAAAAATCCCCAGCAGCTGGGACTGAAGGGAA
GCAGAGATCATGAAGCTTTCTGAATGAGAAGTCTGATTTTTGGAACAGTCCCCTGAAGACCAATGTTGGTCGGCAGAATTAGCAAACTGG
CAAAATCACATTGCAGGAACATATTGGAAAAATTGTACCCTTTACTAAAGAAATAAACTTCAATATTTTCTCTTCTAACCAACTTAAAAG
ACACCAATCTACCTAACTCATCTGGCTCAAGGGACTTGGACTGGAGGATACAGGCTAAAGTGACACTTATCAGAATCTTCCTCAAGCACT
TGCTGGAAAAGATATCAGATTGGAACTTCTTGTTTAAAATTAAGCTTTAGTAAAACAAAGTGATGAGGTTAGGAAGGCAGACTCTACACA
TGTCAGATTGACATATCCCCACAATTTCCGGAACCTACATGTATAGCTGTTTACAAAATCTCCAAGTTAATTAAGGGCACTTTAGGAAGT
TGTCCTCATGAATTAGCTAGCATTAGCATAATTACCGACGTTGCATGCTGTGAGGAGGCTACAAAGGCCAGGCTGGTGTCGGAAGTAATA
ATACATATAGAATTCCATTCTAATAAATGCCATTAGTGTATAACATCAAGTTCTGTGTAATGAGGCTATTTCCAAGTCTCCAAAGATGGT
CACTGTAACAGCACTTTGCTGAGAGGGTTTTAACAAATCATATTAGCCAAAAAGCCTACAACATAGATGCATTTAGCAAACCATGTACAA
ATCAATCACTATAATAAACTGCATCATTTGATAGAGTCACCGTTTTTGCATGTAGTGTTAGAGTATCACAAAATATAACAAGTTTTACTA
AAGGATGGTTGGTTTTTTCAGGATTTAAGGGAATATGGACAAATTGTTAAATAGTATTTATTTGATAAATGGGAGTTTGTATGCAGAAAG
AGTGAATTGCGTATAAAAAGGGTGATTTAAAAACCCAGAAACAAAAGGTAGAATAGGGCTGAAGCATCTGATAATAGGAAAAGAAAAGGA
CAAAAGTCCTCAACTTGTGAGCAATATGCTTTCCCTTTACACCCTGTAATTTATTCAAATGATATTAAAATACAAGACCATTGCAATTTA
TGCTTTTCGCCTGGCAGTTATTTTCCCCCCCAAGCTATCCTGTTTCAGATAATATCAATTTATTTCCAATCCATCAGACTAAAATCTAAG
AAAATTCAAGAACTCTTTTATTGTTGATTTGGTGCCACCAAATTCTTTTTCTTTTTAAATCTTTCTAATTATCCTTTCTTTTTCAATCCC

>In-frame_ENST00000377475_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(amino acids)=1234AA_start in transcript=426_stop in transcript=4130
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLL
EMKCCANLTGGYMVMGDSFNTSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
CGLDPTSTLGIYFEVVNQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQ
NKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIK
LPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYR
TSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRW
VYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLV
QKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIK
HGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEA
TPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGRE

--------------------------------------------------------------
>In-frame_ENST00000377465_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(transcript)=5824nt_BP=1654nt
GCTTCTGGGAGGAGGCCTTTTCTTGACAGTTTAGGGTAGCGGGGGAATGGATGATCCGGGAGTCCCCTGCGGATGTCGTCCCGCACCAGG
CCGGGACCGATTTCTGGCTCCAGTTTCCCCAGAATTGCGGAGTGCGCACACCTGGAAGGACCCAAGTCCCGTTTTATAGTTGAGAAACTC
AAGACTCAGACAAGTGAAACGACTTTTGCTTCATGACAGCTGGAACTGGAACCCAGTTCCCTTTTAGACTATGGCGACATACCTGGAGTT
CATCCAGCAGAATGAAGAACGGGATGGTGTGCGTTTTAGTTGGAACGTGTGGCCTTCCAGCCGGCTGGAGGCTACAAGAATGGTTGTACC
CCTGGCTTGTCTCCTTACTCCTTTGAAAGAACGTCCAGACCTACCTCCTGTACAATATGAACCTGTGCTTTGCAGCAGGCCAACTTGTAA
AGCTGTTCTCAACCCACTTTGTCAGGTTGATTATCGAGCAAAACTTTGGGCCTGTAATTTCTGTTTTCAAAGAAATCAGTTTCCTCCAGC
TTATGGAGGCATATCTGAGGTGAATCAACCTGCCGAATTGATGCCCCAGTTTTCTACAATTGAGTACGTGATACAGCGAGGTGCTCAGTC
CCCTCTGATCTTTCTCTATGTGGTTGACACATGCCTGGAGGAAGATGACCTTCAAGCACTCAAAGAGTCCCTGCAGATGTCCCTGAGTCT
TCTTCCTCCAGATGCTCTGGTGGGTCTGATCACATTTGGAAGGATGGTGCAGGTTCATGAGCTAAGCTGTGAAGGAATCTCCAAAAGTTA
TGTCTTCCGAGGGACCAAGGATTTAACTGCAAAGCAAATACAGGATATGTTGGGCCTGACCAAGCCAGCCATGCCCATGCAGCAAGCACG
ACCTGCACAACCACAGGAGCACCCTTTTGCTTCAAGCAGATTTCTGCAGCCTGTTCACAAGATTGATATGAACCTCACTGATCTTCTTGG
GGAGCTACAGAGGGACCCATGGCCAGTAACTCAGGGGAAGAGACCTTTGCGATCCACTGGTGTGGCTTTGTCCATTGCTGTTGGCTTGCT
GGAGGGCACTTTTCCAAACACAGGAGCCAGGATCATGCTGTTTACTGGAGGTCCCCCTACCCAAGGGCCTGGCATGGTGGTTGGAGATGA
ATTAAAGATTCCTATTCGTTCTTGGCATGATATTGAGAAAGATAATGCACGATTCATGAAAAAGGCAACCAAGCACTATGAGATGCTTGC
TAATCGAACAGCTGCAAATGGTCACTGCATTGATATTTATGCTTGTGCCCTTGATCAAACTGGACTTTTGGAGATGAAGTGTTGTGCAAA
TCTTACTGGAGGCTACATGGTAATGGGAGATTCTTTCAACACTTCTCTCTTCAAGCAGACATTCCAAAGAATCTTTACTAAAGATTTTAA
TGGAGATTTCCGAATGGCATTTGGTGCTACTTTGGACGTAAAGACCTCTCGGGAACTGAAGATTGCAGGAGCCATTGGTCCATGCGTATC
TCTGAATGTGAAAGGACCGTGTGTGTCAGAAAATGAGCTTGGTGTTGGTGGCACGAGTCAGTGGAAAATCTGTGGCCTAGATCCTACATC
TACACTTGGCATCTATTTTGAAGTTGTCAATCAGGAAGAAAACAAAGGTGAAGAGAAATCTCTCAAAACCAAGTCAACTCCAGTCACGTC
TGAAGAGCCACACACCAACATACAAGACAAACTCTCCAAGAAAAATTCCTCTGGAGATCTGACCACAAACCCTGACCCTCAAAATGCAGC
AGAACCAACTGGAACAGTGCCAGAGCAGAAGGAAATGGACCCCGGGAAAGAAGGTCCAAACAGCCCACAAAACAAACCGCCTGCAGCTCC
TGTTATAAATGAGTATGCCGATGCCCAGCTACACAACCTGGTGAAAAGAATGCGTCAAAGAACAGCCCTCTACAAGAAAAAGTTGGTAGA
GGGAGATCTCTCCTCACCCGAAGCCAGCCCACAAACTGCAAAGCCCACGGCTGTACCACCAGTAAAAGAAAGCGATGATAAGCCAACAGA
ACATTACTACAGGCTGTTGTGGTTCAAAGTCAAAAAGATGCCTTTAACAGAGTACTTAAAGCGAATTAAACTTCCAAACAGCATAGATTC
ATACACAGATCGACTCTATCTCCTGTGGCTCTTGCTTGTCACTCTTGCCTATAACTGGAACTGCTGTTTTATACCACTGCGCCTCGTCTT
CCCATATCAAACCGCAGACAACATACACTACTGGCTTATTGCGGACATCATATGTGATATCATCTACCTTTATGATATGCTATTTATCCA
GCCCAGACTCCAGTTTGTAAGAGGAGGAGACATAATAGTGGATTCAAATGAGCTAAGGAAACACTACAGGACTTCTACAAAATTTCAGTT
GGATGTCGCATCAATAATACCATTTGATATTTGCTACCTCTTCTTTGGGTTTAATCCAATGTTTAGAGCAAATAGGATGTTAAAGTACAC
TTCATTTTTTGAATTTAATCATCACCTAGAGTCTATAATGGACAAAGCATATATCTACAGAGTTATTCGAACAACTGGATACTTGCTGTT
TATTCTGCACATTAATGCCTGTGTTTATTACTGGGCTTCAAACTATGAAGGAATTGGCACTACTAGATGGGTGTATGATGGGGAAGGAAA
CGAGTATCTGAGATGTTATTATTGGGCAGTTCGAACTTTAATTACCATTGGTGGCCTTCCAGAACCACAAACTTTATTTGAAATTGTTTT
TCAACTCTTGAATTTTTTTTCTGGAGTTTTTGTGTTCTCCAGTTTAATTGGTCAGATGAGAGATGTGATTGGAGCAGCTACAGCCAATCA
GAACTACTTCCGCGCCTGCATGGATGACACCATTGCCTACATGAACAATTACTCCATTCCTAAACTTGTGCAAAAGCGAGTTCGGACTTG
GTATGAATATACATGGGACTCTCAAAGAATGCTAGATGAGTCTGATTTGCTTAAGACCCTACCAACTACGGTCCAGTTAGCCCTCGCCAT
TGATGTGAACTTCAGCATCATCAGCAAAGTCGACTTGTTCAAGGGTTGTGATACACAGATGATTTATGACATGTTGCTAAGATTGAAATC
CGTTCTCTATTTGCCTGGTGACTTTGTCTGCAAAAAGGGAGAAATTGGCAAGGAAATGTATATCATCAAGCATGGAGAAGTCCAAGTTCT
TGGAGGCCCTGATGGTACTAAAGTTCTGGTTACTCTGAAAGCTGGGTCGGTGTTTGGAGAAATCAGCCTTCTAGCAGCAGGAGGAGGAAA
CCGTCGAACTGCCAATGTGGTGGCCCACGGGTTTGCCAATCTTTTAACTCTAGACAAAAAGACCCTCCAAGAAATTCTAGTGCATTATCC
AGATTCTGAAAGGATCCTCATGAAGAAAGCCAGAGTGCTTTTAAAGCAGAAGGCTAAGACCGCAGAAGCAACCCCTCCAAGAAAAGATCT
TGCCCTCCTCTTCCCACCGAAAGAAGAGACACCCAAACTGTTTAAAACTCTCCTAGGAGGCACAGGAAAAGCAAGTCTTGCAAGACTACT
CAAATTGAAGCGAGAGCAAGCAGCTCAGAAGAAAGAAAATTCTGAAGGAGGAGAGGAAGAAGGAAAAGAAAATGAAGATAAACAAAAAGA
AAATGAAGATAAACAAAAAGAAAATGAAGATAAAGGAAAAGAAAATGAAGATAAAGATAAAGGAAGAGAGCCAGAAGAGAAGCCACTGGA
CAGACCTGAATGTACAGCAAGTCCTATTGCAGTGGAGGAAGAACCCCACTCAGTTAGAAGGACAGTTTTACCCAGAGGGACTTCTCGTCA
ATCACTCATTATCAGCATGGCTCCTTCTGCTGAGGGCGGAGAAGAGGTTCTTACTATTGAAGTCAAAGAAAAGGCTAAGCAATAAATGTT
TGATTATCTTTAGATGTGATATAGCTAGTTCCCAAAGTGATTGTACCTAGGATTGTAACTTAAATTAACGAGGGGAAACGACATGCTGGG
ACCCTTGAGAAACGAAAGGCAAATCCCTAGCTTAGTTTCTAGGACTTATCTGAGAGTGTGATTTCATGCAGTGGTAATAAGAAGATTATT
AAAAGCCATCCCTATTCTCCGTTTTCATTAACTTTATGCAATTGCTATATCTTCTAATTGTATGTAGTAAGTTTCCTTTTCCTTTGGTTC
TTTCCTGATGATGTCTCTTCCTTCCAGTTTTATTAGCTTGCTCTTGGCTGTGATGTGATTCACTAACCTTTTCTCTTAATTTTTATTGTG
TTTAATTTCTTCTTTGGCACTCTAAAGCCTGGCTAATTGTTCTAGGTTTATGAATTTCACCTCTTACATGTAAAGGGTATAAGATTTTAA
TGTAATAGGTCAAAAATCAGATTATTTTCATTCAAATGAGGATGATGAGTCACTGTAATATCAAAAAATCCCCAGCAGCTGGGACTGAAG
GGAAGCAGAGATCATGAAGCTTTCTGAATGAGAAGTCTGATTTTTGGAACAGTCCCCTGAAGACCAATGTTGGTCGGCAGAATTAGCAAA
CTGGCAAAATCACATTGCAGGAACATATTGGAAAAATTGTACCCTTTACTAAAGAAATAAACTTCAATATTTTCTCTTCTAACCAACTTA
AAAGACACCAATCTACCTAACTCATCTGGCTCAAGGGACTTGGACTGGAGGATACAGGCTAAAGTGACACTTATCAGAATCTTCCTCAAG
CACTTGCTGGAAAAGATATCAGATTGGAACTTCTTGTTTAAAATTAAGCTTTAGTAAAACAAAGTGATGAGGTTAGGAAGGCAGACTCTA
CACATGTCAGATTGACATATCCCCACAATTTCCGGAACCTACATGTATAGCTGTTTACAAAATCTCCAAGTTAATTAAGGGCACTTTAGG
AAGTTGTCCTCATGAATTAGCTAGCATTAGCATAATTACCGACGTTGCATGCTGTGAGGAGGCTACAAAGGCCAGGCTGGTGTCGGAAGT
AATAATACATATAGAATTCCATTCTAATAAATGCCATTAGTGTATAACATCAAGTTCTGTGTAATGAGGCTATTTCCAAGTCTCCAAAGA
TGGTCACTGTAACAGCACTTTGCTGAGAGGGTTTTAACAAATCATATTAGCCAAAAAGCCTACAACATAGATGCATTTAGCAAACCATGT
ACAAATCAATCACTATAATAAACTGCATCATTTGATAGAGTCACCGTTTTTGCATGTAGTGTTAGAGTATCACAAAATATAACAAGTTTT
ACTAAAGGATGGTTGGTTTTTTCAGGATTTAAGGGAATATGGACAAATTGTTAAATAGTATTTATTTGATAAATGGGAGTTTGTATGCAG
AAAGAGTGAATTGCGTATAAAAAGGGTGATTTAAAAACCCAGAAACAAAAGGTAGAATAGGGCTGAAGCATCTGATAATAGGAAAAGAAA
AGGACAAAAGTCCTCAACTTGTGAGCAATATGCTTTCCCTTTACACCCTGTAATTTATTCAAATGATATTAAAATACAAGACCATTGCAA
TTTATGCTTTTCGCCTGGCAGTTATTTTCCCCCCCAAGCTATCCTGTTTCAGATAATATCAATTTATTTCCAATCCATCAGACTAAAATC
TAAGAAAATTCAAGAACTCTTTTATTGTTGATTTGGTGCCACCAAATTCTTTTTCTTTTTAAATCTTTCTAATTATCCTTTCTTTTTCAA

>In-frame_ENST00000377465_ENST00000320005_TCGA-37-A5EL-01A_SEC23B_chr20_18516386_-_CNGB3_chr8_87751964_length(amino acids)=1234AA_start in transcript=250_stop in transcript=3954
MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQ
RNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSC
EGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVAL
SIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLL
EMKCCANLTGGYMVMGDSFNTSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKI
CGLDPTSTLGIYFEVVNQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQ
NKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIK
LPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYR
TSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRW
VYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLV
QKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIK
HGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEA
TPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGRE

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Fusion Gene PPI Analysis for SEC23B-CNGB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEC23B-CNGB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEC23B-CNGB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC23BC1306589Congenital dyserythropoietic anemia, type II5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSEC23BC0002876Congenital dyserythropoietic anemia1CTD_human;GENOMICS_ENGLAND
HgeneSEC23BC0018553Hamartoma Syndrome, Multiple1ORPHANET
HgeneSEC23BC0271933Congenital dyserythropoietic anemia, type I1CTD_human
HgeneSEC23BC0271934Congenital dyserythropoietic anemia, type III1CTD_human
HgeneSEC23BC4225179COWDEN SYNDROME 71CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCNGB3C1849792Achromatopsia 36CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCNGB3C0009398Color vision defect1CTD_human
TgeneCNGB3C0152200Achromatopsia1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneCNGB3C0155015Color Blindness, Red1CTD_human
TgeneCNGB3C0155016Color Blindness, Red-Green1CTD_human
TgeneCNGB3C0155017Color Blindness, Blue1CTD_human
TgeneCNGB3C0155018Color Blindness, Acquired1CTD_human
TgeneCNGB3C0239777Color Blindness, Green1CTD_human
TgeneCNGB3C0242225Color blindness1CTD_human
TgeneCNGB3C0271092Progressive cone dystrophy (without rod involvement)1ORPHANET
TgeneCNGB3C0271093Stargardt's disease1CTD_human;ORPHANET
TgeneCNGB3C0751042Color Blindness, Inherited1CTD_human
TgeneCNGB3C0751043Monochromatopsia1CTD_human
TgeneCNGB3C1855465STARGARDT DISEASE 1 (disorder)1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT