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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEL1L3-CCKAR (FusionGDB2 ID:79721)

Fusion Gene Summary for SEL1L3-CCKAR

check button Fusion gene summary
Fusion gene informationFusion gene name: SEL1L3-CCKAR
Fusion gene ID: 79721
HgeneTgene
Gene symbol

SEL1L3

CCKAR

Gene ID

23231

886

Gene nameSEL1L family member 3cholecystokinin A receptor
SynonymsSel-1L3CCK-A|CCK1-R|CCK1R|CCKRA
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionprotein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 3cholecystokinin receptor type ACCK-A receptorCCK-ARcholecystokinin type-A receptorcholecystokinin-1 receptor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000399878, ENST00000264868, 
ENST00000502949, ENST00000513364, 
ENST00000295589, 
Fusion gene scores* DoF score11 X 12 X 7=9241 X 1 X 1=1
# samples 122
** MAII scorelog2(12/924*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/1*10)=4.32192809488736
Context

PubMed: SEL1L3 [Title/Abstract] AND CCKAR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEL1L3(25759156)-CCKAR(26484905), # samples:3
Anticipated loss of major functional domain due to fusion event.SEL1L3-CCKAR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCKAR

GO:0038188

cholecystokinin signaling pathway

8503909


check buttonFusion gene breakpoints across SEL1L3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCKAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A925-01ASEL1L3chr4

25759156

-CCKARchr4

26484905

-
ChimerDB4STADTCGA-VQ-A925SEL1L3chr4

25759155

-CCKARchr4

26484905

-
ChimerDB4STADTCGA-VQ-A925-01ASEL1L3chr4

25759156

-CCKARchr4

26484905

-
ChimerDB4STADTCGA-VQ-A925-01ASEL1L3chr4

25759156

-CCKARchr4

26484905

-


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Fusion Gene ORF analysis for SEL1L3-CCKAR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000399878ENST00000295589SEL1L3chr4

25759156

-CCKARchr4

26484905

-
Frame-shiftENST00000264868ENST00000295589SEL1L3chr4

25759156

-CCKARchr4

26484905

-
In-frameENST00000502949ENST00000295589SEL1L3chr4

25759156

-CCKARchr4

26484905

-
intron-3CDSENST00000513364ENST00000295589SEL1L3chr4

25759156

-CCKARchr4

26484905

-
Frame-shiftENST00000399878ENST00000295589SEL1L3chr4

25759155

-CCKARchr4

26484905

-
Frame-shiftENST00000264868ENST00000295589SEL1L3chr4

25759155

-CCKARchr4

26484905

-
In-frameENST00000502949ENST00000295589SEL1L3chr4

25759155

-CCKARchr4

26484905

-
intron-3CDSENST00000513364ENST00000295589SEL1L3chr4

25759155

-CCKARchr4

26484905

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502949SEL1L3chr425759156-ENST00000295589CCKARchr426484905-410032011732471076
ENST00000502949SEL1L3chr425759155-ENST00000295589CCKARchr426484905-410032011732471076

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502949ENST00000295589SEL1L3chr425759156-CCKARchr426484905-0.0013016960.99869823
ENST00000502949ENST00000295589SEL1L3chr425759155-CCKARchr426484905-0.0013016960.99869823

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Fusion Genomic Features for SEL1L3-CCKAR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEL1L3-CCKAR


check button Go to

FGviewer for the breakpoints of chr4:25759156-chr4:26484905

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324575_6091051.33333333333331098.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324611_6471051.33333333333331098.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324694_7301051.33333333333331098.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324732_7671051.33333333333331098.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324768_8001051.33333333333331098.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324801_8391051.33333333333331098.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324840_8771051.33333333333331098.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-2324952_9881051.33333333333331098.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324575_6091086.33333333333331133.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324611_6471086.33333333333331133.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324694_7301086.33333333333331133.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324732_7671086.33333333333331133.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324768_8001086.33333333333331133.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324801_8391086.33333333333331133.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324840_8771086.33333333333331133.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-2324952_9881086.33333333333331133.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324575_609933.3333333333334980.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324611_647933.3333333333334980.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324694_730933.3333333333334980.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324732_767933.3333333333334980.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324768_800933.3333333333334980.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324801_839933.3333333333334980.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324840_877933.3333333333334980.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324575_6091051.33333333333331098.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324611_6471051.33333333333331098.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324694_7301051.33333333333331098.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324732_7671051.33333333333331098.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324768_8001051.33333333333331098.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324801_8391051.33333333333331098.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324840_8771051.33333333333331098.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-2324952_9881051.33333333333331098.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324575_6091086.33333333333331133.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324611_6471086.33333333333331133.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324694_7301086.33333333333331133.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324732_7671086.33333333333331133.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324768_8001086.33333333333331133.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324801_8391086.33333333333331133.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324840_8771086.33333333333331133.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-2324952_9881086.33333333333331133.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324575_609933.3333333333334980.0RepeatNote=Sel1-like 1
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324611_647933.3333333333334980.0RepeatNote=Sel1-like 2
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324694_730933.3333333333334980.0RepeatNote=Sel1-like 3
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324732_767933.3333333333334980.0RepeatNote=Sel1-like 4
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324768_800933.3333333333334980.0RepeatNote=Sel1-like 5
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324801_839933.3333333333334980.0RepeatNote=Sel1-like 6
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324840_877933.3333333333334980.0RepeatNote=Sel1-like 7
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000399878-23241057_10771086.33333333333331133.0TransmembraneHelical
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000399878-23241057_10771086.33333333333331133.0TransmembraneHelical
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925235_313208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925335_349208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925374_428208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925235_313208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925335_349208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925374_428208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925211_234208.66666666666666429.0TransmembraneHelical%3B Name%3D5
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925314_334208.66666666666666429.0TransmembraneHelical%3B Name%3D6
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925350_373208.66666666666666429.0TransmembraneHelical%3B Name%3D7
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925211_234208.66666666666666429.0TransmembraneHelical%3B Name%3D5
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925314_334208.66666666666666429.0TransmembraneHelical%3B Name%3D6
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925350_373208.66666666666666429.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-2324952_988933.3333333333334980.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-2324952_988933.3333333333334980.0RepeatNote=Sel1-like 8
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000264868-23241057_10771051.33333333333331098.0TransmembraneHelical
HgeneSEL1L3chr4:25759155chr4:26484905ENST00000502949-23241057_1077933.3333333333334980.0TransmembraneHelical
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000264868-23241057_10771051.33333333333331098.0TransmembraneHelical
HgeneSEL1L3chr4:25759156chr4:26484905ENST00000502949-23241057_1077933.3333333333334980.0TransmembraneHelical
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925105_115208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925138_157208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925179_210208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST00000295589251_41208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759155chr4:26484905ENST000002955892568_77208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925105_115208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925138_157208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925179_210208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST00000295589251_41208.66666666666666429.0Topological domainExtracellular
TgeneCCKARchr4:25759156chr4:26484905ENST000002955892568_77208.66666666666666429.0Topological domainCytoplasmic
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925116_137208.66666666666666429.0TransmembraneHelical%3B Name%3D3
TgeneCCKARchr4:25759155chr4:26484905ENST0000029558925158_178208.66666666666666429.0TransmembraneHelical%3B Name%3D4
TgeneCCKARchr4:25759155chr4:26484905ENST000002955892542_67208.66666666666666429.0TransmembraneHelical%3B Name%3D1
TgeneCCKARchr4:25759155chr4:26484905ENST000002955892578_104208.66666666666666429.0TransmembraneHelical%3B Name%3D2
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925116_137208.66666666666666429.0TransmembraneHelical%3B Name%3D3
TgeneCCKARchr4:25759156chr4:26484905ENST0000029558925158_178208.66666666666666429.0TransmembraneHelical%3B Name%3D4
TgeneCCKARchr4:25759156chr4:26484905ENST000002955892542_67208.66666666666666429.0TransmembraneHelical%3B Name%3D1
TgeneCCKARchr4:25759156chr4:26484905ENST000002955892578_104208.66666666666666429.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for SEL1L3-CCKAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000502949_ENST00000295589_TCGA-VQ-A925-01A_SEL1L3_chr4_25759156_-_CCKAR_chr4_26484905_length(transcript)=4100nt_BP=3201nt
CACACTCGCCCTGCGCCCTGCGGGAATGGCGCCCCGGCCAAAAAAGCAACCAGACAAAAACCCATTGCACGGGCGGGAACTGGTCTGTGC
GACCCGCAAAAGGGAATGTTGTACCATCTTTGGGTAGGCAGACTTCCCTGACGACATCAGTGATACCCAAAGCTGAGCAGAGCGTGGCTT
ACAAAGACTTTATTTATTTTACTGTCTTTGAAGGAAACGTTCGCAACGTTTCTGAAGTCTCGGTTGAGTATTTATGCTCTCAGCCTTGTG
TTGTCAATTTGGAAGCAGTTGTTTCATCTGAGTTCAGAAGTAGCATTCCCGTGTACAAAAAAAGGTGGAAGAATGAGAAACATCTTCACA
CCAGCAGGACACAAATAGTACATGTGAAATTTCCAAGCATTATGGTTTACAGAGATGATTATTTCATCAGACATTCCATCTCTGTATCTG
CAGTGATAGTACGCGCCTGGATTACTCACAAATACAGTGGCAGAGACTGGAATGTTAAATGGGAGGAAAACTTGCTCCATGCTGTAGCAA
AGAATTATACCCTCCTGCAGACCATCCCGCCTTTTGAACGCCCTTTCAAAGATCATCAAGTGTGCCTTGAGTGGAACATGGGTTATATTT
GGAACCTTCGGGCAAACAGGATTCCACAGTGTCCTCTGGAAAATGATGTGGTTGCCCTGCTTGGCTTTCCTTATGCCTCCAGTGGAGAAA
ACACAGGCATTGTCAAGAAGTTCCCGAGGTTTCGGAACCGAGAGCTGGAGGCCACTCGACGCCAGAGGATGGATTACCCAGTGTTTACTG
TTTCATTGTGGCTTTATTTACTCCATTATTGCAAGGCCAACCTCTGTGGGATTCTGTACTTTGTTGACTCTAATGAGATGTACGGCACAC
CTTCTGTATTTCTTACGGAAGAGGGCTATTTGCATATTCAGATGCATCTTGTCAAAGGGGAAGACCTTGCTGTAAAAACTAAATTCATCA
TACCTTTGAAGGAGTGGTTTCGACTGGATATCTCTTTTAACGGAGGCCAGATAGTAGTAACCACTAGCATTGGACAGGATTTGAAAAGCT
ACCACAATCAGACCATTAGCTTCCGGGAGGATTTCCATTATAATGACACAGCTGGGTACTTCATTATTGGAGGGAGCAGGTATGTGGCTG
GCATTGAAGGGTTTTTTGGACCCCTGAAGTACTATCGCCTTCGCAGTCTGCACCCCGCCCAGATTTTTAATCCCCTCCTTGAGAAGCAAC
TTGCTGAACAAATCAAGTTATATTATGAAAGGTGTGCTGAGGTTCAAGAAATAGTATCTGTGTATGCATCTGCAGCAAAGCACGGGGGCG
AGAGACAAGAAGCATGCCACCTCCACAACTCCTACCTGGACCTCCAGCGCAGGTATGGGAGACCCTCGATGTGCAGAGCCTTCCCCTGGG
AGAAGGAGCTGAAAGACAAACACCCCAGCTTGTTCCAGGCATTGCTGGAGATGGATCTGCTGACCGTGCCAAGGAACCAAAATGAATCTG
TATCAGAAATCGGTGGGAAGATATTTGAGAAGGCTGTAAAGAGACTCTCTAGCATTGATGGTCTTCACCAAATTAGCTCTATCGTCCCCT
TTCTGACGGATTCCAGCTGCTGTGGATACCATAAAGCATCCTACTACCTTGCAGTCTTTTATGAGACTGGATTAAATGTTCCTCGGGATC
AGCTGCAGGGCATGTTGTATAGTTTGGTTGGAGGCCAGGGGAGTGAGAGGCTGTCTTCAATGAATCTTGGGTATAAACACTACCAGGGTA
TTGACAACTACCCCCTGGACTGGGAACTGTCGTATGCCTACTACAGCAACATTGCCACCAAGACACCCCTTGACCAGCACACACTGCAAG
GAGATCAGGCATATGTTGAAACAATTAGACTAAAAGATGATGAAATACTCAAGGTACAAACCAAAGAAGATGGAGATGTCTTTATGTGGT
TGAAGCATGAAGCTACCCGAGGCAATGCAGCAGCTCAGCAACGATTGGCCCAGATGCTGTTCTGGGGGCAGCAAGGTGTGGCCAAGAATC
CCGAAGCAGCAATTGAGTGGTACGCCAAGGGCGCCCTGGAGACGGAGGATCCTGCGTTAATCTATGACTATGCCATTGTGCTATTCAAGG
GTCAAGGAGTAAAAAAGAACAGACGGCTTGCCTTAGAGCTGATGAAGAAAGCAGCTTCCAAGGGATTGCATCAGGCAGTCAATGGCCTGG
GATGGTATTACCACAAATTCAAGAAAAATTACGCCAAAGCAGCAAAGTACTGGTTAAAAGCAGAAGAAATGGGGAACCCAGATGCGTCAT
ACAATCTTGGAGTCCTGCATTTGGATGGCATCTTCCCTGGAGTTCCTGGAAGGAATCAAACTTTAGCTGGTGAATATTTCCATAAGGCTG
CGCAAGGTGGACACATGGAAGGGACCTTGTGGTGTTCTCTCTACTATATCACAGGCAACCTGGAGACATTCCCTAGAGATCCTGAGAAAG
CTGTTGTATGGGCAAAACATGTAGCTGAGAAAAATGGCTACTTGGGCCATGTCATCCGCAAAGGCCTCAATGCCTACCTGGAAGGTTCAT
GGCATGAAGCTTTGCTGTATTATGTTTTAGCAGCAGAAACTGGAATTGAAGTGTCACAGACAAATTTAGCACACATCTGTGAGGAGAGGC
CAGACCTGGCCAGGAGATACTTGGGTGTTAACTGTGTTTGGAGATACTATAATTTCTCTGTTTTTCAAATCGATGCTCCTTCCTTTGCAT
ATTTGAAGATGGGAGACCTTTACTACTATGGCCACCAAAACCAGTCACAAGACCTGGAGTTGTCTGTGCAGATGTACGCCCAAGCCGCCC
TGGATGGAGACTCCCAGGGATTTTTTAACCTGGCCCTGCTAATCGAGGAAGGTACGATAATCCCACACCATATCTTGGATTTCTTGGAAA
TTGACTCAACTCTCCATTCTAATAACATCTCCATTCTCCAGGAACTGTACGAAAGGTGCTGGAGCCACAGTAACGAGGAGTCCTTCAGCC
CCTGCTCCTTGGCCTGGCTTTACCTGCACTTGCGGCTTCTCTGGGGTGCTATCCTGCACTCAGCCCTGATCTACTTTCTGGGAACCTTTC
TGCTATCCATATTGATCGCCTGGACTGTGCAGTATTTCCAGTCTGTCTCAGGCACACATTCCTGTTACTCATCCTCTTTCTTATTCCTGG
AATTGTGATGATGGTGGCATATGGATTAATCTCTTTGGAACTCTACCAGGGAATAAAATTTGAGGCTAGCCAGAAGAAGTCTGCTAAAGA
AAGGAAACCTAGCACCACCAGCAGCGGCAAATATGAGGACAGCGATGGGTGTTACCTGCAAAAGACCAGGCCCCCGAGGAAGCTGGAGCT
CCGGCAGCTGTCCACCGGCAGCAGCAGCAGGGCCAACCGCATCCGGAGTAACAGCTCCGCAGCCAACCTGATGGCCAAGAAAAGGGTGAT
CCGCATGCTCATCGTCATCGTGGTCCTCTTCTTCCTGTGCTGGATGCCCATCTTCAGCGCCAACGCCTGGCGGGCCTACGACACCGCCTC
CGCAGAGCGCCGCCTCTCAGGAACCCCCATTTCCTTCATCCTCCTCCTGTCCTACACCTCCTCCTGCGTCAACCCCATCATCTACTGCTT
CATGAACAAACGCTTCCGCCTCGGCTTCATGGCCACCTTCCCCTGCTGCCCCAATCCTGGTCCCCCAGGGGCGAGGGGAGAGGTGGGGGA
GGAGGAGGAAGGCGGGACCACAGGAGCCTCTCTGTCCAGGTTCTCGTACAGCCATATGAGTGCCTCGGTGCCACCCCAGTGAGATGTCCC
CTGACCCTCCACCGCAGAAGGAAGGCAGGGAGGAGGCAGAGAAGAAAGAACGGAAGAAGAGATCAGGAAGAGAAGGAGCAGAGCTGATGG
AGAAGGAAGGCTCCATCTCCAGTGGGAACTCTTCAAGGTCTGCTTTTCATCCTTCATCTGGATTCCAGAGCACTGCTCCAGTGGGGCCAT

>In-frame_ENST00000502949_ENST00000295589_TCGA-VQ-A925-01A_SEL1L3_chr4_25759156_-_CCKAR_chr4_26484905_length(amino acids)=1076AA_start in transcript=17_stop in transcript=3247
MREWRPGQKSNQTKTHCTGGNWSVRPAKGNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEA
VVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLL
QTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLY
LLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTI
SFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEAC
HLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSS
CCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQAYV
ETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKK
NRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGRNQTLAGEYFHKAAQGGHM
EGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEVSQTNLAHICEERPDLARR
YLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEGTIIPHHILDFLEIDSTLH

--------------------------------------------------------------
>In-frame_ENST00000502949_ENST00000295589_TCGA-VQ-A925_SEL1L3_chr4_25759155_-_CCKAR_chr4_26484905_length(transcript)=4100nt_BP=3201nt
CACACTCGCCCTGCGCCCTGCGGGAATGGCGCCCCGGCCAAAAAAGCAACCAGACAAAAACCCATTGCACGGGCGGGAACTGGTCTGTGC
GACCCGCAAAAGGGAATGTTGTACCATCTTTGGGTAGGCAGACTTCCCTGACGACATCAGTGATACCCAAAGCTGAGCAGAGCGTGGCTT
ACAAAGACTTTATTTATTTTACTGTCTTTGAAGGAAACGTTCGCAACGTTTCTGAAGTCTCGGTTGAGTATTTATGCTCTCAGCCTTGTG
TTGTCAATTTGGAAGCAGTTGTTTCATCTGAGTTCAGAAGTAGCATTCCCGTGTACAAAAAAAGGTGGAAGAATGAGAAACATCTTCACA
CCAGCAGGACACAAATAGTACATGTGAAATTTCCAAGCATTATGGTTTACAGAGATGATTATTTCATCAGACATTCCATCTCTGTATCTG
CAGTGATAGTACGCGCCTGGATTACTCACAAATACAGTGGCAGAGACTGGAATGTTAAATGGGAGGAAAACTTGCTCCATGCTGTAGCAA
AGAATTATACCCTCCTGCAGACCATCCCGCCTTTTGAACGCCCTTTCAAAGATCATCAAGTGTGCCTTGAGTGGAACATGGGTTATATTT
GGAACCTTCGGGCAAACAGGATTCCACAGTGTCCTCTGGAAAATGATGTGGTTGCCCTGCTTGGCTTTCCTTATGCCTCCAGTGGAGAAA
ACACAGGCATTGTCAAGAAGTTCCCGAGGTTTCGGAACCGAGAGCTGGAGGCCACTCGACGCCAGAGGATGGATTACCCAGTGTTTACTG
TTTCATTGTGGCTTTATTTACTCCATTATTGCAAGGCCAACCTCTGTGGGATTCTGTACTTTGTTGACTCTAATGAGATGTACGGCACAC
CTTCTGTATTTCTTACGGAAGAGGGCTATTTGCATATTCAGATGCATCTTGTCAAAGGGGAAGACCTTGCTGTAAAAACTAAATTCATCA
TACCTTTGAAGGAGTGGTTTCGACTGGATATCTCTTTTAACGGAGGCCAGATAGTAGTAACCACTAGCATTGGACAGGATTTGAAAAGCT
ACCACAATCAGACCATTAGCTTCCGGGAGGATTTCCATTATAATGACACAGCTGGGTACTTCATTATTGGAGGGAGCAGGTATGTGGCTG
GCATTGAAGGGTTTTTTGGACCCCTGAAGTACTATCGCCTTCGCAGTCTGCACCCCGCCCAGATTTTTAATCCCCTCCTTGAGAAGCAAC
TTGCTGAACAAATCAAGTTATATTATGAAAGGTGTGCTGAGGTTCAAGAAATAGTATCTGTGTATGCATCTGCAGCAAAGCACGGGGGCG
AGAGACAAGAAGCATGCCACCTCCACAACTCCTACCTGGACCTCCAGCGCAGGTATGGGAGACCCTCGATGTGCAGAGCCTTCCCCTGGG
AGAAGGAGCTGAAAGACAAACACCCCAGCTTGTTCCAGGCATTGCTGGAGATGGATCTGCTGACCGTGCCAAGGAACCAAAATGAATCTG
TATCAGAAATCGGTGGGAAGATATTTGAGAAGGCTGTAAAGAGACTCTCTAGCATTGATGGTCTTCACCAAATTAGCTCTATCGTCCCCT
TTCTGACGGATTCCAGCTGCTGTGGATACCATAAAGCATCCTACTACCTTGCAGTCTTTTATGAGACTGGATTAAATGTTCCTCGGGATC
AGCTGCAGGGCATGTTGTATAGTTTGGTTGGAGGCCAGGGGAGTGAGAGGCTGTCTTCAATGAATCTTGGGTATAAACACTACCAGGGTA
TTGACAACTACCCCCTGGACTGGGAACTGTCGTATGCCTACTACAGCAACATTGCCACCAAGACACCCCTTGACCAGCACACACTGCAAG
GAGATCAGGCATATGTTGAAACAATTAGACTAAAAGATGATGAAATACTCAAGGTACAAACCAAAGAAGATGGAGATGTCTTTATGTGGT
TGAAGCATGAAGCTACCCGAGGCAATGCAGCAGCTCAGCAACGATTGGCCCAGATGCTGTTCTGGGGGCAGCAAGGTGTGGCCAAGAATC
CCGAAGCAGCAATTGAGTGGTACGCCAAGGGCGCCCTGGAGACGGAGGATCCTGCGTTAATCTATGACTATGCCATTGTGCTATTCAAGG
GTCAAGGAGTAAAAAAGAACAGACGGCTTGCCTTAGAGCTGATGAAGAAAGCAGCTTCCAAGGGATTGCATCAGGCAGTCAATGGCCTGG
GATGGTATTACCACAAATTCAAGAAAAATTACGCCAAAGCAGCAAAGTACTGGTTAAAAGCAGAAGAAATGGGGAACCCAGATGCGTCAT
ACAATCTTGGAGTCCTGCATTTGGATGGCATCTTCCCTGGAGTTCCTGGAAGGAATCAAACTTTAGCTGGTGAATATTTCCATAAGGCTG
CGCAAGGTGGACACATGGAAGGGACCTTGTGGTGTTCTCTCTACTATATCACAGGCAACCTGGAGACATTCCCTAGAGATCCTGAGAAAG
CTGTTGTATGGGCAAAACATGTAGCTGAGAAAAATGGCTACTTGGGCCATGTCATCCGCAAAGGCCTCAATGCCTACCTGGAAGGTTCAT
GGCATGAAGCTTTGCTGTATTATGTTTTAGCAGCAGAAACTGGAATTGAAGTGTCACAGACAAATTTAGCACACATCTGTGAGGAGAGGC
CAGACCTGGCCAGGAGATACTTGGGTGTTAACTGTGTTTGGAGATACTATAATTTCTCTGTTTTTCAAATCGATGCTCCTTCCTTTGCAT
ATTTGAAGATGGGAGACCTTTACTACTATGGCCACCAAAACCAGTCACAAGACCTGGAGTTGTCTGTGCAGATGTACGCCCAAGCCGCCC
TGGATGGAGACTCCCAGGGATTTTTTAACCTGGCCCTGCTAATCGAGGAAGGTACGATAATCCCACACCATATCTTGGATTTCTTGGAAA
TTGACTCAACTCTCCATTCTAATAACATCTCCATTCTCCAGGAACTGTACGAAAGGTGCTGGAGCCACAGTAACGAGGAGTCCTTCAGCC
CCTGCTCCTTGGCCTGGCTTTACCTGCACTTGCGGCTTCTCTGGGGTGCTATCCTGCACTCAGCCCTGATCTACTTTCTGGGAACCTTTC
TGCTATCCATATTGATCGCCTGGACTGTGCAGTATTTCCAGTCTGTCTCAGGCACACATTCCTGTTACTCATCCTCTTTCTTATTCCTGG
AATTGTGATGATGGTGGCATATGGATTAATCTCTTTGGAACTCTACCAGGGAATAAAATTTGAGGCTAGCCAGAAGAAGTCTGCTAAAGA
AAGGAAACCTAGCACCACCAGCAGCGGCAAATATGAGGACAGCGATGGGTGTTACCTGCAAAAGACCAGGCCCCCGAGGAAGCTGGAGCT
CCGGCAGCTGTCCACCGGCAGCAGCAGCAGGGCCAACCGCATCCGGAGTAACAGCTCCGCAGCCAACCTGATGGCCAAGAAAAGGGTGAT
CCGCATGCTCATCGTCATCGTGGTCCTCTTCTTCCTGTGCTGGATGCCCATCTTCAGCGCCAACGCCTGGCGGGCCTACGACACCGCCTC
CGCAGAGCGCCGCCTCTCAGGAACCCCCATTTCCTTCATCCTCCTCCTGTCCTACACCTCCTCCTGCGTCAACCCCATCATCTACTGCTT
CATGAACAAACGCTTCCGCCTCGGCTTCATGGCCACCTTCCCCTGCTGCCCCAATCCTGGTCCCCCAGGGGCGAGGGGAGAGGTGGGGGA
GGAGGAGGAAGGCGGGACCACAGGAGCCTCTCTGTCCAGGTTCTCGTACAGCCATATGAGTGCCTCGGTGCCACCCCAGTGAGATGTCCC
CTGACCCTCCACCGCAGAAGGAAGGCAGGGAGGAGGCAGAGAAGAAAGAACGGAAGAAGAGATCAGGAAGAGAAGGAGCAGAGCTGATGG
AGAAGGAAGGCTCCATCTCCAGTGGGAACTCTTCAAGGTCTGCTTTTCATCCTTCATCTGGATTCCAGAGCACTGCTCCAGTGGGGCCAT

>In-frame_ENST00000502949_ENST00000295589_TCGA-VQ-A925_SEL1L3_chr4_25759155_-_CCKAR_chr4_26484905_length(amino acids)=1076AA_start in transcript=17_stop in transcript=3247
MREWRPGQKSNQTKTHCTGGNWSVRPAKGNVVPSLGRQTSLTTSVIPKAEQSVAYKDFIYFTVFEGNVRNVSEVSVEYLCSQPCVVNLEA
VVSSEFRSSIPVYKKRWKNEKHLHTSRTQIVHVKFPSIMVYRDDYFIRHSISVSAVIVRAWITHKYSGRDWNVKWEENLLHAVAKNYTLL
QTIPPFERPFKDHQVCLEWNMGYIWNLRANRIPQCPLENDVVALLGFPYASSGENTGIVKKFPRFRNRELEATRRQRMDYPVFTVSLWLY
LLHYCKANLCGILYFVDSNEMYGTPSVFLTEEGYLHIQMHLVKGEDLAVKTKFIIPLKEWFRLDISFNGGQIVVTTSIGQDLKSYHNQTI
SFREDFHYNDTAGYFIIGGSRYVAGIEGFFGPLKYYRLRSLHPAQIFNPLLEKQLAEQIKLYYERCAEVQEIVSVYASAAKHGGERQEAC
HLHNSYLDLQRRYGRPSMCRAFPWEKELKDKHPSLFQALLEMDLLTVPRNQNESVSEIGGKIFEKAVKRLSSIDGLHQISSIVPFLTDSS
CCGYHKASYYLAVFYETGLNVPRDQLQGMLYSLVGGQGSERLSSMNLGYKHYQGIDNYPLDWELSYAYYSNIATKTPLDQHTLQGDQAYV
ETIRLKDDEILKVQTKEDGDVFMWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKK
NRRLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIFPGVPGRNQTLAGEYFHKAAQGGHM
EGTLWCSLYYITGNLETFPRDPEKAVVWAKHVAEKNGYLGHVIRKGLNAYLEGSWHEALLYYVLAAETGIEVSQTNLAHICEERPDLARR
YLGVNCVWRYYNFSVFQIDAPSFAYLKMGDLYYYGHQNQSQDLELSVQMYAQAALDGDSQGFFNLALLIEEGTIIPHHILDFLEIDSTLH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SEL1L3-CCKAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEL1L3-CCKAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEL1L3-CCKAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCCKARC0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
TgeneCCKARC0036341Schizophrenia5PSYGENET
TgeneCCKARC0001956Alcohol Use Disorder1CTD_human
TgeneCCKARC0005586Bipolar Disorder1PSYGENET
TgeneCCKARC0016978gallbladder neoplasm1CTD_human
TgeneCCKARC0033975Psychotic Disorders1PSYGENET
TgeneCCKARC0036349Paranoid Schizophrenia1PSYGENET
TgeneCCKARC0041696Unipolar Depression1PSYGENET
TgeneCCKARC0085762Alcohol abuse1CTD_human
TgeneCCKARC0153452Malignant neoplasm of gallbladder1CTD_human
TgeneCCKARC1269683Major Depressive Disorder1PSYGENET