|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SERGEF-SPTY2D1 (FusionGDB2 ID:80067) |
Fusion Gene Summary for SERGEF-SPTY2D1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SERGEF-SPTY2D1 | Fusion gene ID: 80067 | Hgene | Tgene | Gene symbol | SERGEF | SPTY2D1 | Gene ID | 26297 | 144108 |
| Gene name | secretion regulating guanine nucleotide exchange factor | SPT2 chromatin protein domain containing 1 | |
| Synonyms | DELGEF|Gnefr | Spt2 | |
| Cytomap | 11p15.1 | 11p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | secretion-regulating guanine nucleotide exchange factordeafness locus associated putative guanine nucleotide exchange factorguanine nucleotide exchange factor-related protein | protein SPT2 homologSPT2 domain-containing protein 1SPT2, Suppressor of Ty, domain containing 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000265965, ENST00000528200, ENST00000532265, ENST00000532212, | ENST00000336349, ENST00000543776, | |
| Fusion gene scores | * DoF score | 9 X 8 X 7=504 | 2 X 1 X 2=4 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
| Context | PubMed: SERGEF [Title/Abstract] AND SPTY2D1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SERGEF(18010143)-SPTY2D1(18638536), # samples:2 SPTY2D1(18655745)-SERGEF(17809960), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | SERGEF-SPTY2D1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SERGEF | GO:0050709 | negative regulation of protein secretion | 12459492 |
| Fusion gene breakpoints across SERGEF (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SPTY2D1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-2H-A9GN | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| ChimerDB4 | ESCA | TCGA-2H-A9GN | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
Top |
Fusion Gene ORF analysis for SERGEF-SPTY2D1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000265965 | ENST00000336349 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| 5CDS-5UTR | ENST00000265965 | ENST00000543776 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| Frame-shift | ENST00000528200 | ENST00000336349 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| 5CDS-5UTR | ENST00000528200 | ENST00000543776 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| In-frame | ENST00000532265 | ENST00000336349 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| 5CDS-5UTR | ENST00000532265 | ENST00000543776 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| intron-3CDS | ENST00000532212 | ENST00000336349 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| intron-5UTR | ENST00000532212 | ENST00000543776 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000532265 | SERGEF | chr11 | 18010143 | - | ENST00000336349 | SPTY2D1 | chr11 | 18638536 | - | 6345 | 887 | 833 | 2884 | 683 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000532265 | ENST00000336349 | SERGEF | chr11 | 18010143 | - | SPTY2D1 | chr11 | 18638536 | - | 0.000281132 | 0.99971884 |
Top |
Fusion Genomic Features for SERGEF-SPTY2D1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for SERGEF-SPTY2D1 |
| Go to FGviewer for the breakpoints of chr11:18010143-chr11:18638536 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 120_171 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 3 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 15_67 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 1 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 172_230 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 4 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 231_283 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 5 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 68_119 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 2 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 120_171 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 3 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 15_67 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 1 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 172_230 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 4 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 231_283 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 5 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 68_119 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 2 |
| Tgene | SPTY2D1 | chr11:18010143 | chr11:18638536 | ENST00000336349 | 0 | 6 | 123_148 | 20.0 | 686.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SPTY2D1 | chr11:18010143 | chr11:18638536 | ENST00000336349 | 0 | 6 | 45_81 | 20.0 | 686.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SPTY2D1 | chr11:18010143 | chr11:18638536 | ENST00000336349 | 0 | 6 | 645_685 | 20.0 | 686.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SPTY2D1 | chr11:18010143 | chr11:18638536 | ENST00000336349 | 0 | 6 | 278_552 | 20.0 | 686.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SPTY2D1 | chr11:18010143 | chr11:18638536 | ENST00000336349 | 0 | 6 | 591_595 | 20.0 | 686.0 | Compositional bias | Note=Poly-Asp |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 284_351 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 6 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000265965 | - | 8 | 11 | 352_402 | 281.3333333333333 | 459.0 | Repeat | Note=RCC1 7 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 284_351 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 6 |
| Hgene | SERGEF | chr11:18010143 | chr11:18638536 | ENST00000528200 | - | 8 | 10 | 352_402 | 281.3333333333333 | 351.6666666666667 | Repeat | Note=RCC1 7 |
Top |
Fusion Gene Sequence for SERGEF-SPTY2D1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000532265_ENST00000336349_TCGA-2H-A9GN_SERGEF_chr11_18010143_-_SPTY2D1_chr11_18638536_length(transcript)=6345nt_BP=887nt TGGGTACGTGACTCCGCCCCCGGGCCGGTGCAGGCCCTGAGGGGCGCCGAGATGTGGGAGCTGCTGGCCGCGGCGTGGGCAGTTCAGGGG CTGGGCGGCTGAGGGTGCAAATAGCTATGGGCAACTTGGCCTCGGCCATAAGGAAGATGTGCTGTTGCCCCAGCAACTGAATGACTTCTG TAAACCCAGGAGTGTCAGGAGGATCACAGGAGGAGGGGGCCACTCTGCAGTTGTCACAGATGGAGGAGACCTCTTTGTTTGTGGCCTGAA CAAAGATGGGCAACTGGGGCTTGGTCACACAGAGGATATCCCATATTTTACCCCCTGCAAATCCCTCTTTGGCTGTCCCATCCAACAGGT GGCCTGTGGCTGGGATTTTACGATTATGCTCACAGAAAATGGTCAAGTTCTATCATGTGGATCCAACTCCTTTGGCCAGTTAGGAGTTCC TCATGGACCTCGAAGATGTGTGGTTCCCCAGGCCATTGAGCTCCATAAAGAGAAGGTTGTTTGTATTGCTGCTGGACTGAGGCATGCAGT AGCTGCTACAGCGAGTGGCATCGTGTTCCAGTGGGGGACTGGTTTGGCATCATGTGGACGACGGTTGTGCCCTGGGCAGACTCTTCCATT GTTTTTCACAGCAAAGGAACCAAGCAGAGTGACAGGTCTAGAGAATTCTAAAGCAATGTGTGTTCTTGCTGGCTCAGACCACTCAGCTTC ATTAACAGATGCAGGAGAGGTGTATGTTTGGGGAAGCAACAAGCATGGGCAACTGGCTAATGAGGCTGCTTTCCTTCCTGTGCCCCAGAA AATAGAAGCACATTGTTTCCAGAATGAAAAGGTCACTGCCATCTGGAGTGGATGGACACACCTGGTTGCTCAGACAGAAAAGGTATAGTT TGGCAGTGGGGCCTCCAAAAAAAGACCCAAAAGTTAAAGGTGTCCAATCAGCAGCTGTACAAGCTTTTCTTAAAAGGAAAGAAGAGGAGC TGAGACGAAAAGCCTTAGAGGAGAAAAGGAGAAAAGAGGAACTAGTGAAAAAGCGAATTGAGCTCAAACATGACAAGAAAGCAAGAGCTA TGGCCAAGAGGACAAAGGATAATTTCCATGGTTACAATGGGATTCCTATTGAGGAAAAGTCAAAGAAGAGGCAGGCAACAGAAAGCCATA CCAGCCAAGGAACCGACCGAGAGTATGAAATGGAAGAAGAGAATGAATTCCTCGAGTACAATCACGCAGAGTCAGAGCAGGAGTATGAGG AAGAGCAAGAACCTCCCAAAGTTGAAAGCAAACCAAAGGTCCCCCTTAAAAGTGCCCCACCACCCATGAACTTCACTGATTTACTCAGGC TGGCTGAGAAAAAGCAGTTTGAACCAGTGGAAATCAAGGTAGTGAAGAAATCAGAAGAGCGACCTATGACCGCAGAAGAACTTAGGGAGC GAGAATTCCTTGAACGAAAGCATAGGAGAAAAAAACTTGAGACAGATGGAAAACTACCTCCAACTGTGTCCAAAAAGGCACCCTCTCAGA AAGAAAGTGTGGGCACAAAACTTAGCAAAGGTTCTGGAGACAGGCATCCTTCTTCCAAAGGAATGCCCCTTCCTCATGCTGAGAAGAAAT CAAGACCCAGCATGGCCAATGAGAAACACCTCGCTTTGTCTTCATCCAAATCCATGCCAGGAGAGAGGATCAAGGCAGGATCTGGCAATA GCTCCCAACCCTCACTTCGTGAGGGCCACGACAAACCTGTTTTTAATGGAGCTGGAAAGCCTCATTCCAGCACCTCTTCACCAAGTGTCC CAAAGACTTCTGCTAGCAGGACTCAGAAATCTGCTGTTGAGCACAAAGCCAAAAAATCTCTGTCCCATCCTAGCCATTCCAGGCCTGGGC CCATGGTCACCCCACACAATAAGGCTAAGAGTCCAGGTGTCAGGCAGCCAGGCAGCAGCTCTAGCTCAGCCCCTGGGCAGCCCAGCACAG GGGTTGCTCGACCCACAGTTAGTTCTGGCCCTGTGCCTAGGCGCCAGAATGGCAGCTCCAGCTCAGGACCTGAGCGATCAATCAGTGGGT CCAAGAAGCCAACCAATGACTCAAATCCCTCTAGGCGGACAGTCAGTGGTACATGTGGCCCTGGACAACCTGCAAGCAGCTCAGGTGGCC CTGGGCGACCCATCAGTGGTTCAGTTAGTTCTGCAAGACCCTTGGGCAGCTCTCGTGGCCCTGGCCGGCCTGTGAGCAGTCCACATGAAC TTCGACGACCAGTGAGTGGCTTGGGCCCCCCGGGGCGGTCTGTCAGTGGCCCTGGGAGATCCATAAGTGGCTCAATTCCAGCTGGACGGA CTGTCAGTAATTCAGTCCCAGGAAGACCAGTGAGCAGCTTGGGACCTGGGCAAACAGTTAGTAGCTCAGGTCCCACTATAAAGCCTAAGT GCACTGTTGTCTCCGAAACAATTTCTTCCAAGAATATCATTAGCCGGTCCAGCAATGGACAGATGAATGGAATGAAGCCTCCCCTATCTG GCTACAGAGCTGCCCAAGGTCCTCAAAGGCTTCCCTTCCCTACTGGTTACAAAAGGCAGCGAGAATATGAAGAGGAAGATGACGATGATG ATGAATACGACTCTGAAATGGAAGATTTTATTGAAGATGAAGGAGAGCCTCAGGAAGAAATATCCAAGCACATTAGAGAAATCTTTGGTT ATGACCGAAAAAAATACAAAGATGAAAGTGATTATGCCTTACGTTACATGGAAAGTAGTTGGAAAGAGCAGCAGAAGGAAGAAGCAAAGA GCTTAAGACTGGGTATGCAAGAGGACTTAGAGGAAATGAGACGTGAAGAAGAAGAAATGCAACGTCGAAGGGCCAAGAAGCTGAAGAGGC GTTAGCTGCTGCTTTTATTTTTGTGAAATTCTAGAGCTGCTCTGCTGCAAGGATTTCCTGCCTTCAGACTGAAGAAGCCCCCTTATCATT TTAGATTTATACTTGGGTACTCAAGGAGAAGGAATGCATACTGTCATTTGCAGGCTGTCATTTGAGCATAAAATATTTTCAGATATTTTC CAGGGTGAAATCTGTAATGCAGATGATATAATGCCCACTTGTGCTCTTATGAAGTTAACTGTTCACAGATGCCAGCCTTGATCCTGATGA GCTATGCACTCTAATGTGGGGCCACTCACCAGTCAGCCAATCTTTTATTGTTCCTTTGCTACTTTGAAAGGAAAAAAAAGGTTGTCTCTT GATTTCTGTAATTCTTCTGCTGATCTGTGAGTAGGGCACTGCCCTGCTCCCAATCAAACTTAGTCTTTTTATGAGAAACCTGGACCTTCC ATGAATGTTGCCAGCAATAAAGTGACTTGTCCTAATCTATGGATTGAGAACTTGAAAATGTAGAGTAGAATTTATAACTATCATATGGAT GTCATCCTGTGACTTTGAAGTACAAAGTAGAATAAATTCTGTATTCATGGATTGGATGCTGAGCATTCTTACTCATTAATTTAGGTGGCT AGGAATTAATGAAAAAATTTTCAAGTTAAAATACAGGTTATAACAGTATAATATTCTTTTCTAAGTTTTCCTTTCAGATTTACTGTTATG TTGGCTTTAGTGTAAGACAAGGTCACTGTGCTGATTGATTTTTATCTAAAAAAATTCATTTTTATATCGAAGAAAAAATATTTTATTCAA ACATTAGATTTGAAAGAGTAATAGTTTATAAAATAAGGAAGTAACATGTGAGGCTCTCCCCTCCTCCCCTCCCCCATCATAAAGATATTT TGAAATCCCAAGGTGCCCTCATACCTCTTGACATTAATGACTTCATTTTTTAGCTTGAATTTGTTAGCAAATATTAATGGCAGAAAACCA AAAACTAAATTTATGGTATCGAGAGCACCACCTTCTCTTTTTGCCCATATTGCACTTTGATTTCAAACTATGCACTGTGAAGAGATTTTT TTCCCCAGGTAGGAAGGGATGTTCCCTGTTATCGTTATTTTACTGAGCTGTGGAAACTCATTTTTACCCTTTTTAAAGTCATAAATATGG ACTTAATAGCCCTTAACCTTCAAGTCCAAGCAGTTCCAATCAGGCTGACTTAGGATCATGCTGGAAGGAAGCCAAGTCTCAAGAACTGTC AGCAACAGAAAATGAGATATGATGCTAGAGAGCATTTGTCCTTGACTGTAAGTACAGAGGCTTAGGGGAAGTGAGACATAAGCTTGTAGG AATAATAAACGTTCTACAATAAACGTTTTGGCTATCTTAAGCCATTGTATGGGGGGGATTAGGAAGTAGGAGGGATTGTCCTACAACAGG CCCTTATACTTCAACAGCCCAAATATTTTGGTTTATTCCTTTTTATCCATAAAGTCTTTATTCTTCAAGTTTGGGTATTATAGATTACCA TTGTTAGCCTCCCTTAATGGGACCATATGAGCCAGGCTTTTAAGACGGACTCATTTTGAATTGAGTTTCAAACTTTGAAAGTGCAAGGAT TTAATTTTTAAGTTGAATCCCATGAAAGGTGTCATCATCACTAGGAATAACACCCTTTGTAACTACATATAGAACTGTTACAATGGTAGC AGAAAATCCTATTGATTTCATCTCACCCATTTCAGATACCTTCAGTGAAATTAAGGGTAGTGTGATGTCCCATGTAATAAAACAGGCTTA GAACATCAATTCCTCTGCTGCCATTTATGTGCTTTTATTCCCCCTTCAAAAATTTTTTATTGGATATATATATTTTTCAGTATTCAGACT CTGAAATCTGTCATTACAATCAAGTGCTTGTCACAGCTGAAAGATTTCTGGTGGCTTAAAGTTTACTAGCAGTAAATTTATGATATGGTA CAGTTCTTTGTACAGAAAGGCACCATTATGTTAGAATAAATTTCCAGAACTTAGTGGGAAGAATCAGGTTTTAACCTTGTGTGTCTGTTA CTTCTGAGTGCATTTCTATAATATAAATGTTGATTTGCGTCAACATTATAAAAGAGCACTTCTGTGGCTCATTTAAAAGAAAAAAAAGGT TAAGTCTTTTAAATTTTGGCCTTGTTTCCAAATCCTGTCTTCCATGTTGTTTTTCTGCACTTCCTGACCACTCTTATAAAAAGCTCACAA ACCTTTGAAGAAACTGGAGTAGGCTGTTATTTCATTAAGGTTTACAAATTAAATGCTTGATTTTTAATGTATTCTCTACTGTTTTGATTT TTGGATTTTCTTAATTCAACATTTGAAGATGTGCCTTTTGGGTAATGTTAATCACGAATGTAGTAATATTTCATGATTGTAATAATGTTA CATGATCATGGGTGTGGCATTCTCTAACAAATGATGTGAAAGGAAAGTAGTTTTCATAAAACTCATGGCTCTGATTGCACAGTCCCACTT GCTTTTGATATTGCTATGTCAAAGCAAAGGGCACTTCTTTTAAGGCTACTTTCAGAACTTTGTATTTTCGCTAAACTATAAATGCAGTTG TGTCCAGTTGGAGGCCAGGGTACCACATGTCACAGGCGGCCTTACATGTGTGCCGTGAAAAGGTTCAAAGACCGTTAACAAAAAAGTAAG TCTGGCCGGGCATGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACTTGAGACCAGGAGTTCGAGACCA GCCTGGCCAACATGGTGTGAGACCCCGTCTCTACTAAAAATAAAAAAATTAGCCGGGTGCGGTGGCACACACCTGTAATCCCAGCTACCG GGGAGGCTGAGGCAGGAGAATCGCTAGAACCTGGGAGGCGGAGGTTGCAGTCAGCCAAGATAGCACCACTGCACTCCAGGCTGGGTGACA GAGCGAGACTCCATGTCAAAAAAAAAAGAATGTGGGAACTCAAATTTTCATTTTTAATGTAATCCCCAAGATTTTCTCCAAGAAATAAAT TGTTGTTTTGTATTTTGTAACTTAAAAGCAGCTATTGGTAAATTTCTGAGATATAGCAGGAGACCAAAACATGTTTGGAAAGAGAATAAA TATATGAAGAGAGACTGGTTGTTTTATTTTCAATGTATTGAATATATTAGACTACTATTTATTTTCTGAGTGGATGTGATTAAATATTCA GACGTTTAGTGTATGATTAAGAGTGAGATAGAGATTTCTTTGGAGTAATTAAATCCATCCTGTCTTTTACACAATGGACAAATCAAGTTA AAAAAATTTTTAGATAGCTTAGCTTGTTTTCTGGTGCTGTTGACCTGCAAGAGAATATACTTTTGCATATACAGGTGAAAGTTTTGCAAT >In-frame_ENST00000532265_ENST00000336349_TCGA-2H-A9GN_SERGEF_chr11_18010143_-_SPTY2D1_chr11_18638536_length(amino acids)=683AA_start in transcript=833_stop in transcript=2884 MKRSLPSGVDGHTWLLRQKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDN FHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFE PVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANE KHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNK AKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGS VSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETI SSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKD -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for SERGEF-SPTY2D1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for SERGEF-SPTY2D1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for SERGEF-SPTY2D1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies