FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ATP5B-ALDOA (FusionGDB2 ID:8007)

Fusion Gene Summary for ATP5B-ALDOA

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5B-ALDOA
Fusion gene ID: 8007
HgeneTgene
Gene symbol

ATP5B

ALDOA

Gene ID

506

112694756

Gene nameATP synthase F1 subunit betauncharaterized LOC112694756
SynonymsATP5B|ATPMB|ATPSB|HEL-S-271ALDA|ALDOA
Cytomap

12q13.3

-

Type of geneprotein-codingprotein-coding
DescriptionATP synthase subunit beta, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideepididymis secretory protein Li 271mitochondrial ATP synthase beta subunitmitochondrial ATP synthetase, beta subunituncharaterized LOC112694756Fructose-bisphosphate aldolase ALung cancer antigen NY-LU-1Muscle-type aldolase
Modification date2020032720200303
UniProtAcc.

P04075

Ensembl transtripts involved in fusion geneENST00000262030, ENST00000552919, 
ENST00000550162, 		ENST00000338110, 
ENST00000395248, ENST00000575627, 
ENST00000566897, ENST00000569545, 
ENST00000563060, ENST00000412304, 
ENST00000564546, ENST00000564595, 
ENST00000569798, ENST00000395240, 
Fusion gene scores* DoF score17 X 19 X 7=226116 X 16 X 6=1536
# samples 2218
** MAII scorelog2(22/2261*10)=-3.36138556322687
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1536*10)=-3.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP5B [Title/Abstract] AND ALDOA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP5B(57037187)-ALDOA(30080627), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP5B

GO:0042776

mitochondrial ATP synthesis coupled proton transport

12110673


check buttonFusion gene breakpoints across ATP5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALDOA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01AATP5Bchr12

57037187

-ALDOAchr16

30080627

+


Top

Fusion Gene ORF analysis for ATP5B-ALDOA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262030ENST00000338110ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
In-frameENST00000262030ENST00000395248ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000575627ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000566897ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000569545ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000563060ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000412304ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000564546ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000564595ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000569798ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000262030ENST00000395240ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
In-frameENST00000552919ENST00000338110ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
In-frameENST00000552919ENST00000395248ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000575627ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000566897ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000569545ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000563060ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000412304ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000564546ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000564595ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000569798ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
5CDS-intronENST00000552919ENST00000395240ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-3CDSENST00000550162ENST00000338110ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-3CDSENST00000550162ENST00000395248ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000575627ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000566897ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000569545ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000563060ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000412304ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000564546ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000564595ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000569798ATP5Bchr12

57037187

-ALDOAchr16

30080627

+
intron-intronENST00000550162ENST00000395240ATP5Bchr12

57037187

-ALDOAchr16

30080627

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262030ATP5Bchr1257037187-ENST00000338110ALDOAchr1630080627+1600843511397448
ENST00000262030ATP5Bchr1257037187-ENST00000395248ALDOAchr1630080627+1606843511397448
ENST00000552919ATP5Bchr1257037187-ENST00000338110ALDOAchr1630080627+1559802101356448
ENST00000552919ATP5Bchr1257037187-ENST00000395248ALDOAchr1630080627+1565802101356448

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262030ENST00000338110ATP5Bchr1257037187-ALDOAchr1630080627+0.0021912530.99780875
ENST00000262030ENST00000395248ATP5Bchr1257037187-ALDOAchr1630080627+0.0022108210.99778914
ENST00000552919ENST00000338110ATP5Bchr1257037187-ALDOAchr1630080627+0.0018722790.99812776
ENST00000552919ENST00000395248ATP5Bchr1257037187-ALDOAchr1630080627+0.0018957480.9981042

Top

Fusion Genomic Features for ATP5B-ALDOA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATP5Bchr1257037186-ALDOAchr1630080626+6.98E-111
ATP5Bchr1257037186-ALDOAchr1630080626+6.98E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ATP5B-ALDOA


check button Go to

FGviewer for the breakpoints of chr12:57037187-chr16:30080627

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ALDOA

P04075

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP5Bchr12:57037187chr16:30080627ENST00000262030-510207_214264.0530.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ATP5B-ALDOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262030_ENST00000338110_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(transcript)=1600nt_BP=843nt
GAGCAGGCGGCTGCGGTTGCTGCAGCCTTCAGTCTCCACCCGGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCC
TCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTC
AGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGGCGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTC
CAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGAAGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTG
GGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGAAGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAA
ATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGTCATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTT
GCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAGTGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTA
GCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGGTGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTC
GCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCT
GGTGTTATCAACTTAAAAGATGCCACCTCTAAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTG
AAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGTCTACAAGGCTCTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTG
AAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGC
ACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGGAGGCCAGAGTGAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAG
TGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGGCCGAGCCCTGCAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAG
AACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCTGGCCAACAGCCTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCT
GGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGCCTATTAAGCGGAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGC
CCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTCCAGGCTGGCTTGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGG

>In-frame_ENST00000262030_ENST00000338110_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(amino acids)=448AA_start in transcript=51_stop in transcript=1397
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKNGIVPI
VEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQS

--------------------------------------------------------------
>In-frame_ENST00000262030_ENST00000395248_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(transcript)=1606nt_BP=843nt
GAGCAGGCGGCTGCGGTTGCTGCAGCCTTCAGTCTCCACCCGGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCC
TCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCCCCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTC
AGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGGCGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTC
CAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGAAGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTG
GGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGAAGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAA
ATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGTCATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTT
GCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAGTGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTA
GCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGGTGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTC
GCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGGTGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCT
GGTGTTATCAACTTAAAAGATGCCACCTCTAAGAATGGCATTGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTG
AAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGTCTACAAGGCTCTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTG
AAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGC
ACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGGAGGCCAGAGTGAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAG
TGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGGCCGAGCCCTGCAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAG
AACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCTGGCCAACAGCCTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCT
GGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGCCTATTAAGCGGAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGC
CCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTCCAGGCTGGCTTGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGG

>In-frame_ENST00000262030_ENST00000395248_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(amino acids)=448AA_start in transcript=51_stop in transcript=1397
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKNGIVPI
VEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQS

--------------------------------------------------------------
>In-frame_ENST00000552919_ENST00000338110_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(transcript)=1559nt_BP=802nt
GGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCC
CCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTCAGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGG
CGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTCCAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGA
AGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGA
AGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGT
CATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTTGCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAG
TGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTAGCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGG
TGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGG
TGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGAATGGCAT
TGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGT
CTACAAGGCTCTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAA
GTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGG
AGGCCAGAGTGAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGG
CCGAGCCCTGCAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAGAACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCT
GGCCAACAGCCTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCTGGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGC
CTATTAAGCGGAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGCCCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTC
CAGGCTGGCTTGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGGTGTCGTCTGTGAATGCTAAGTCCATCACCCTTTCCGGCACA

>In-frame_ENST00000552919_ENST00000338110_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(amino acids)=448AA_start in transcript=10_stop in transcript=1356
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKNGIVPI
VEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQS

--------------------------------------------------------------
>In-frame_ENST00000552919_ENST00000395248_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(transcript)=1565nt_BP=802nt
GGACTACGCCATGTTGGGGTTTGTGGGTCGGGTGGCCGCTGCTCCGGCCTCCGGGGCCTTGCGGAGACTCACCCCTTCAGCGTCGCTGCC
CCCAGCTCAGCTCTTACTGCGGGCCGCTCCGACGGCGGTCCATCCTGTCAGGGACTATGCGGCGCAAACATCTCCTTCGCCAAAAGCAGG
CGCCGCCACCGGGCGCATCGTGGCGGTCATTGGCGCAGTGGTGGACGTCCAGTTTGATGAGGGACTACCACCAATTCTAAATGCCCTGGA
AGTGCAAGGCAGGGAGACCAGACTGGTTTTGGAGGTGGCCCAGCATTTGGGTGAGAGCACAGTAAGGACTATTGCTATGGATGGTACAGA
AGGCTTGGTTAGAGGCCAGAAAGTACTGGATTCTGGTGCACCAATCAAAATTCCTGTTGGTCCTGAGACTTTGGGCAGAATCATGAATGT
CATTGGAGAACCTATTGATGAAAGAGGTCCCATCAAAACCAAACAATTTGCTCCCATTCATGCTGAGGCTCCAGAGTTCATGGAAATGAG
TGTTGAGCAGGAAATTCTGGTGACTGGTATCAAGGTTGTCGATCTGCTAGCTCCCTATGCCAAGGGTGGCAAAATTGGGCTTTTTGGTGG
TGCTGGAGTTGGCAAGACTGTACTGATCATGGAGTTAATCAACAATGTCGCCAAAGCCCATGGTGGTTACTCTGTGTTTGCTGGTGTTGG
TGAGAGGACCCGTGAAGGCAATGATTTATACCATGAAATGATTGAATCTGGTGTTATCAACTTAAAAGATGCCACCTCTAAGAATGGCAT
TGTGCCCATCGTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGT
CTACAAGGCTCTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAA
GTTTTCTCATGAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGG
AGGCCAGAGTGAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGG
CCGAGCCCTGCAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAGAACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCT
GGCCAACAGCCTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCTGGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGC
CTATTAAGCGGAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGCCCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTC
CAGGCTGGCTTGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGGTGTCGTCTGTGAATGCTAAGTCCATCACCCTTTCCGGCACA

>In-frame_ENST00000552919_ENST00000395248_TCGA-BR-A4PE-01A_ATP5B_chr12_57037187_-_ALDOA_chr16_30080627_length(amino acids)=448AA_start in transcript=10_stop in transcript=1356
MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQG
RETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKNGIVPI
VEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ATP5B-ALDOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ATP5B-ALDOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneALDOAP04075DB14548Zinc sulfate, unspecified formLigandSmall moleculeApproved|Experimental
TgeneALDOAP04075DB14548Zinc sulfate, unspecified formLigandSmall moleculeApproved|Experimental
TgeneALDOAP04075DB01593ZincSmall moleculeApproved|Investigational
TgeneALDOAP04075DB01593ZincSmall moleculeApproved|Investigational
TgeneALDOAP04075DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneALDOAP04075DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneALDOAP04075DB14533Zinc chlorideLigandSmall moleculeApproved|Investigational
TgeneALDOAP04075DB14533Zinc chlorideLigandSmall moleculeApproved|Investigational

Top

Related Diseases for ATP5B-ALDOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALDOAC0272066Glycogen Storage Disease XII7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneALDOAC0017919Glycogen Storage Disease3GENOMICS_ENGLAND
TgeneALDOAC0520572Enzymopathy2GENOMICS_ENGLAND
TgeneALDOAC0006142Malignant neoplasm of breast1CTD_human
TgeneALDOAC0027626Neoplasm Invasiveness1CTD_human
TgeneALDOAC0027627Neoplasm Metastasis1CTD_human
TgeneALDOAC0151744Myocardial Ischemia1CTD_human
TgeneALDOAC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneALDOAC0678222Breast Carcinoma1CTD_human
TgeneALDOAC1257931Mammary Neoplasms, Human1CTD_human
TgeneALDOAC1458155Mammary Neoplasms1CTD_human
TgeneALDOAC4704874Mammary Carcinoma, Human1CTD_human