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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SERINC3-NCOA5 (FusionGDB2 ID:80099)

Fusion Gene Summary for SERINC3-NCOA5

check button Fusion gene summary
Fusion gene informationFusion gene name: SERINC3-NCOA5
Fusion gene ID: 80099
HgeneTgene
Gene symbol

SERINC3

NCOA5

Gene ID

10955

57727

Gene nameserine incorporator 3nuclear receptor coactivator 5
SynonymsAIGP1|DIFF33|SBBI99|TDE|TDE1|TMS-1CIA|bA465L10.6
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionserine incorporator 3tumor differentially expressed protein 1nuclear receptor coactivator 5NCoA-5coactivator independent of AF-2
Modification date2020031320200313
UniProtAcc.

Q9HCD5

Ensembl transtripts involved in fusion geneENST00000255175, ENST00000342374, 
ENST00000541235, ENST00000468234, 
ENST00000290231, 
Fusion gene scores* DoF score7 X 8 X 5=2806 X 6 X 5=180
# samples 88
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERINC3 [Title/Abstract] AND NCOA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSERINC3(43139930)-NCOA5(44691528), # samples:3
Anticipated loss of major functional domain due to fusion event.SERINC3-NCOA5 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SERINC3-NCOA5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERINC3

GO:0009597

detection of virus

26416733|26416734

HgeneSERINC3

GO:0045087

innate immune response

26416733|26416734

HgeneSERINC3

GO:0051607

defense response to virus

26416733|26416734


check buttonFusion gene breakpoints across SERINC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NCOA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PN-01ASERINC3chr20

43139930

-NCOA5chr20

44691528

-
ChimerDB4UCSTCGA-N8-A4PNSERINC3chr20

43139929

-NCOA5chr20

44691528

-
ChimerDB4UCSTCGA-N8-A4PNSERINC3chr20

43139930

-NCOA5chr20

44691528

-
ChimerDB4UCSTCGA-N8-A4PN-01ASERINC3chr20

43139930

-NCOA5chr20

44691528

-
ChimerDB4UCSTCGA-N8-A4PN-01ASERINC3chr20

43139929

-NCOA5chr20

44691527

-


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Fusion Gene ORF analysis for SERINC3-NCOA5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000255175ENST00000290231SERINC3chr20

43139930

-NCOA5chr20

44691528

-
In-frameENST00000342374ENST00000290231SERINC3chr20

43139930

-NCOA5chr20

44691528

-
Frame-shiftENST00000541235ENST00000290231SERINC3chr20

43139930

-NCOA5chr20

44691528

-
intron-3CDSENST00000468234ENST00000290231SERINC3chr20

43139930

-NCOA5chr20

44691528

-
Frame-shiftENST00000255175ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691528

-
In-frameENST00000342374ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691528

-
Frame-shiftENST00000541235ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691528

-
intron-3CDSENST00000468234ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691528

-
Frame-shiftENST00000255175ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691527

-
In-frameENST00000342374ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691527

-
Frame-shiftENST00000541235ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691527

-
intron-3CDSENST00000468234ENST00000290231SERINC3chr20

43139929

-NCOA5chr20

44691527

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342374SERINC3chr2043139930-ENST00000290231NCOA5chr2044691528-25386331581222354
ENST00000342374SERINC3chr2043139929-ENST00000290231NCOA5chr2044691528-25386331581222354
ENST00000342374SERINC3chr2043139929-ENST00000290231NCOA5chr2044691527-25386331581222354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342374ENST00000290231SERINC3chr2043139930-NCOA5chr2044691528-0.0107638920.98923606
ENST00000342374ENST00000290231SERINC3chr2043139929-NCOA5chr2044691528-0.0107638920.98923606
ENST00000342374ENST00000290231SERINC3chr2043139929-NCOA5chr2044691527-0.0107638920.98923606

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Fusion Genomic Features for SERINC3-NCOA5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SERINC3-NCOA5


check button Go to

FGviewer for the breakpoints of chr20:43139930-chr20:44691528

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCOA5

Q9HCD5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411118_132158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411154_159158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-4111_96158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410118_132158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410154_159158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-4101_96158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411118_132158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411154_159158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-4111_96158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410118_132158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410154_159158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-4101_96158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411118_132158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411154_159158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-4111_96158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410118_132158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410154_159158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-4101_96158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411133_153158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-41197_117158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410133_153158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-41097_117158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411133_153158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-41197_117158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410133_153158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-41097_117158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411133_153158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-41197_117158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410133_153158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-41097_117158.33333333333334474.0TransmembraneHelical
TgeneNCOA5chr20:43139929chr20:44691527ENST0000029023168458_579383.3333333333333580.0RegionNote=Transcription activation
TgeneNCOA5chr20:43139929chr20:44691528ENST0000029023168458_579383.3333333333333580.0RegionNote=Transcription activation
TgeneNCOA5chr20:43139930chr20:44691528ENST0000029023168458_579383.3333333333333580.0RegionNote=Transcription activation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411181_203158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411225_239158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411261_329158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411351_406158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411428_446158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411468_473158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410181_203158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410225_239158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410261_329158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410351_406158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410428_446158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410468_473158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411181_203158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411225_239158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411261_329158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411351_406158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411428_446158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411468_473158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410181_203158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410225_239158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410261_329158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410351_406158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410428_446158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410468_473158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411181_203158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411225_239158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411261_329158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411351_406158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411428_446158.33333333333334465.3333333333333Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411468_473158.33333333333334465.3333333333333Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410181_203158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410225_239158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410261_329158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410351_406158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410428_446158.33333333333334474.0Topological domainCytoplasmic
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410468_473158.33333333333334474.0Topological domainExtracellular
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411160_180158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411204_224158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411240_260158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411330_350158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411407_427158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000255175-411447_467158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410160_180158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410204_224158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410240_260158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410330_350158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410407_427158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691527ENST00000342374-410447_467158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411160_180158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411204_224158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411240_260158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411330_350158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411407_427158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000255175-411447_467158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410160_180158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410204_224158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410240_260158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410330_350158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410407_427158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139929chr20:44691528ENST00000342374-410447_467158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411160_180158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411204_224158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411240_260158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411330_350158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411407_427158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000255175-411447_467158.33333333333334465.3333333333333TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410160_180158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410204_224158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410240_260158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410330_350158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410407_427158.33333333333334474.0TransmembraneHelical
HgeneSERINC3chr20:43139930chr20:44691528ENST00000342374-410447_467158.33333333333334474.0TransmembraneHelical
TgeneNCOA5chr20:43139929chr20:44691527ENST00000290231687_150383.3333333333333580.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneNCOA5chr20:43139929chr20:44691528ENST00000290231687_150383.3333333333333580.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneNCOA5chr20:43139930chr20:44691528ENST00000290231687_150383.3333333333333580.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneNCOA5chr20:43139929chr20:44691527ENST0000029023168345_349383.3333333333333580.0MotifNote=LXXLL motif
TgeneNCOA5chr20:43139929chr20:44691528ENST0000029023168345_349383.3333333333333580.0MotifNote=LXXLL motif
TgeneNCOA5chr20:43139930chr20:44691528ENST0000029023168345_349383.3333333333333580.0MotifNote=LXXLL motif
TgeneNCOA5chr20:43139929chr20:44691527ENST00000290231681_158383.3333333333333580.0RegionNote=Transcription repression
TgeneNCOA5chr20:43139929chr20:44691528ENST00000290231681_158383.3333333333333580.0RegionNote=Transcription repression
TgeneNCOA5chr20:43139930chr20:44691528ENST00000290231681_158383.3333333333333580.0RegionNote=Transcription repression


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Fusion Gene Sequence for SERINC3-NCOA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000342374_ENST00000290231_TCGA-N8-A4PN-01A_SERINC3_chr20_43139930_-_NCOA5_chr20_44691528_length(transcript)=2538nt_BP=633nt
GGTGGGCGGGGCCACGCCGTGACGCATCCGTGCGTCTGTGGAAGGCTGCGTTTCCGGCCTGAGAAACCGTCATGTTTCTGGGGAGTCACC
TCAGCTGGCAGTTACCACCGTGTTAGAAAGCAGCCTCAGGACCGGCCACCTCCATCACTGGCGTCACCATGGGGGCTGTGCTGGGTGTCT
TCTCCCTCGCCAGCTGGGTTCCATGCCTCTGCAGCGGTGCCTCATGTTTGCTGTGTAGTTGCTGTCCTAACAGTAAGAATTCCACGGTGA
CTCGCCTCATTTATGCTTTCATTCTCCTCCTGAGCACTGTCGTATCCTATATCATGCAGAGAAAAGAGATGGAAACTTACTTGAAGAAGA
TTCCTGGATTTTGTGAAGGGGGATTTAAAATCCATGAGGCTGATATAAATGCAGATAAAGATTGTGATGTGCTGGTTGGTTATAAAGCTG
TGTATCGGATCAGCTTTGCCATGGCCATCTTTTTCTTTGTCTTTTCTCTGCTCATGTTCAAAGTAAAAACAAGTAAAGATCTCCGAGCGG
CAGTACACAATGGGTTTTGGTTCTTCAAAATTGCTGCCCTTATTGGAATCATGGTTGGCTCTTTCTACATCCCTGGGGGCTATTTCAGCT
CAGGCCCGATTTCCCGCCAACCACTCGGGGCGACCTCGGGTGCCTCGCTGAAGACACAGCCAAGCTCCCAACCGCTCCAGAGCGGCCAAG
TGCTCCCCTCTGCTACACCCACTCCATCTGCACCCCCCACCTCCCAGCAAGAGCTTCAGGCCAAAATCCTCAGCCTCTTCAATAGTGGCA
CAGTGACGGCCAATAGCAGCTCTGCATCCCCCTCGGTTGCTGCCGGAAACACCCCAAACCAGAATTTTTCCACAGCAGCAAACAGCCAGC
CTCAACAAAGATCACAGGCTTCTGGCAATCAGCCTCCAAGCATTTTGGGACAGGGAGGATCTGCTCAGAACATGGGCCCCAGACCTGGGG
CTCCTTCCCAAGGGCTTTTTGGCCAGCCTTCCAGTCGCCTGGCACCTGCTAGCAACATGACTAGCCAGAGGCCTGTGTCTTCCACAGGTA
TCAACTTTGACAATCCAAGTGTACAGAAGGCTCTGGATACCCTGATCCAGAGTGGCCCTGCTCTCTCCCACCTGGTTAGCCAGACCACAG
CACAGATGGGGCAGCCACAGGCCCCCATGGGATCTTACCAGAGGCATTACTGAAGCTAAATCTTTCAACTCTCCCCAGTCCCCTCATCCC
CTGGCCTCCTCCCACTTACTTGTTCTAAATAGAGCTGTTTGGAGGATGTTCTCTGCGCTCCCAGGCCGGCATCGAGTGTCATCAATTTCT
ACCACCTGCTCTCTCTTCTGCCCAAGGCTGTGTTGCTTATTCCTTACAAAGTTTATACTGCATTTGGGGCTGTATCTTTTTTTGTTTTTT
GTTTTGTAGAAAATAAATATCTCCGGGGGCAGTACAGGTGTCTGGGCTTGTATTTGATGGGGTTTCTCCGGTCCCTGTTTCTACTGGATT
TGGAGCCAGGCCCAGCTAGCCAAGTTTGGAATGGCATTTGTCATGTCAGTAGCCACCACCTTTGTTCATTGTGAACCTACCAAGGCTTTC
CAGCTTCATACACATTGACCAGAGCTCAAGCTCCTGCCTGCAACTCCTGCCTAGAGTTGAAGAAAAGCAAACTGGCCTTGGCAGGCACAG
TGTCATCATACCCTCACCCCATATGTTTGGGGTCTGCTTGAGGATTCATAAATCAGCCACTCTGGATTGTTGAGGAATGGCCATGGCAGC
CACAGAAAAAAGAATTTTTCTCTCTGAGCCAAGGTTGTTTTTTGTTTTTTTCTCTTTTCTTTTTTGTTTTCATTTCATTGGAAGATCTCC
AATGGACTGAACAGCTCCAGTCAGCAGCAGTTACCACAAACTGTGAATCTGGGCCCCACCACTCTTCCCTGTTAACCAGTTCTGTCAGCA
TCCCCCTCTCCAGCAGCACTTCCATGAAGTTGGTTCTGAGACTCTGGCCGTGAACACCCGTTTCTTCAGTGATTTGTTTTGGGCTTTTGG
CTCAAAACCCCAGGCTCTTGTTTTTGTCTAGACTCTTATTCTGTTTCCTGAGCAGCAGGAGGTAGGGACCACTTTGATGTCAGACTTCTG
GTAGCTGGACATGTTCTCGAGATGGGTGGCTGTTCGCGACTTTTGTACCAGAGTGAAATTGTTAGAAGGAGGGTTTCTGGCTGTGGTTCT
AAATGGAGCCCCAGGAAGCTGCCCTCTCCCCAGGGTTTGTGCTCAGTAGAGCCCTGTGGATCACAGTCTTGAGGTCCTCTAGCAGGGGTG
AGGGAGAGCAGCGACTTCAGCTGAGTCCCTGCCAGTGGTTAAGCAAACAATGGTTTCAAAATTCAAGGTCCCCAAATGGCAGCATTTTAT
GTTCTGACCTGTTTGTGTTATATAGTGGTTTTTTTTTTCCTCTTTGGAACTCTTGTGTTGTTAATAAAATGAAATGATTACTTTTTAATT

>In-frame_ENST00000342374_ENST00000290231_TCGA-N8-A4PN-01A_SERINC3_chr20_43139930_-_NCOA5_chr20_44691528_length(amino acids)=354AA_start in transcript=158_stop in transcript=1222
MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCD
VLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSGPISRQPLGATSGASLKTQPSS
QPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQ

--------------------------------------------------------------
>In-frame_ENST00000342374_ENST00000290231_TCGA-N8-A4PN_SERINC3_chr20_43139929_-_NCOA5_chr20_44691528_length(transcript)=2538nt_BP=633nt
GGTGGGCGGGGCCACGCCGTGACGCATCCGTGCGTCTGTGGAAGGCTGCGTTTCCGGCCTGAGAAACCGTCATGTTTCTGGGGAGTCACC
TCAGCTGGCAGTTACCACCGTGTTAGAAAGCAGCCTCAGGACCGGCCACCTCCATCACTGGCGTCACCATGGGGGCTGTGCTGGGTGTCT
TCTCCCTCGCCAGCTGGGTTCCATGCCTCTGCAGCGGTGCCTCATGTTTGCTGTGTAGTTGCTGTCCTAACAGTAAGAATTCCACGGTGA
CTCGCCTCATTTATGCTTTCATTCTCCTCCTGAGCACTGTCGTATCCTATATCATGCAGAGAAAAGAGATGGAAACTTACTTGAAGAAGA
TTCCTGGATTTTGTGAAGGGGGATTTAAAATCCATGAGGCTGATATAAATGCAGATAAAGATTGTGATGTGCTGGTTGGTTATAAAGCTG
TGTATCGGATCAGCTTTGCCATGGCCATCTTTTTCTTTGTCTTTTCTCTGCTCATGTTCAAAGTAAAAACAAGTAAAGATCTCCGAGCGG
CAGTACACAATGGGTTTTGGTTCTTCAAAATTGCTGCCCTTATTGGAATCATGGTTGGCTCTTTCTACATCCCTGGGGGCTATTTCAGCT
CAGGCCCGATTTCCCGCCAACCACTCGGGGCGACCTCGGGTGCCTCGCTGAAGACACAGCCAAGCTCCCAACCGCTCCAGAGCGGCCAAG
TGCTCCCCTCTGCTACACCCACTCCATCTGCACCCCCCACCTCCCAGCAAGAGCTTCAGGCCAAAATCCTCAGCCTCTTCAATAGTGGCA
CAGTGACGGCCAATAGCAGCTCTGCATCCCCCTCGGTTGCTGCCGGAAACACCCCAAACCAGAATTTTTCCACAGCAGCAAACAGCCAGC
CTCAACAAAGATCACAGGCTTCTGGCAATCAGCCTCCAAGCATTTTGGGACAGGGAGGATCTGCTCAGAACATGGGCCCCAGACCTGGGG
CTCCTTCCCAAGGGCTTTTTGGCCAGCCTTCCAGTCGCCTGGCACCTGCTAGCAACATGACTAGCCAGAGGCCTGTGTCTTCCACAGGTA
TCAACTTTGACAATCCAAGTGTACAGAAGGCTCTGGATACCCTGATCCAGAGTGGCCCTGCTCTCTCCCACCTGGTTAGCCAGACCACAG
CACAGATGGGGCAGCCACAGGCCCCCATGGGATCTTACCAGAGGCATTACTGAAGCTAAATCTTTCAACTCTCCCCAGTCCCCTCATCCC
CTGGCCTCCTCCCACTTACTTGTTCTAAATAGAGCTGTTTGGAGGATGTTCTCTGCGCTCCCAGGCCGGCATCGAGTGTCATCAATTTCT
ACCACCTGCTCTCTCTTCTGCCCAAGGCTGTGTTGCTTATTCCTTACAAAGTTTATACTGCATTTGGGGCTGTATCTTTTTTTGTTTTTT
GTTTTGTAGAAAATAAATATCTCCGGGGGCAGTACAGGTGTCTGGGCTTGTATTTGATGGGGTTTCTCCGGTCCCTGTTTCTACTGGATT
TGGAGCCAGGCCCAGCTAGCCAAGTTTGGAATGGCATTTGTCATGTCAGTAGCCACCACCTTTGTTCATTGTGAACCTACCAAGGCTTTC
CAGCTTCATACACATTGACCAGAGCTCAAGCTCCTGCCTGCAACTCCTGCCTAGAGTTGAAGAAAAGCAAACTGGCCTTGGCAGGCACAG
TGTCATCATACCCTCACCCCATATGTTTGGGGTCTGCTTGAGGATTCATAAATCAGCCACTCTGGATTGTTGAGGAATGGCCATGGCAGC
CACAGAAAAAAGAATTTTTCTCTCTGAGCCAAGGTTGTTTTTTGTTTTTTTCTCTTTTCTTTTTTGTTTTCATTTCATTGGAAGATCTCC
AATGGACTGAACAGCTCCAGTCAGCAGCAGTTACCACAAACTGTGAATCTGGGCCCCACCACTCTTCCCTGTTAACCAGTTCTGTCAGCA
TCCCCCTCTCCAGCAGCACTTCCATGAAGTTGGTTCTGAGACTCTGGCCGTGAACACCCGTTTCTTCAGTGATTTGTTTTGGGCTTTTGG
CTCAAAACCCCAGGCTCTTGTTTTTGTCTAGACTCTTATTCTGTTTCCTGAGCAGCAGGAGGTAGGGACCACTTTGATGTCAGACTTCTG
GTAGCTGGACATGTTCTCGAGATGGGTGGCTGTTCGCGACTTTTGTACCAGAGTGAAATTGTTAGAAGGAGGGTTTCTGGCTGTGGTTCT
AAATGGAGCCCCAGGAAGCTGCCCTCTCCCCAGGGTTTGTGCTCAGTAGAGCCCTGTGGATCACAGTCTTGAGGTCCTCTAGCAGGGGTG
AGGGAGAGCAGCGACTTCAGCTGAGTCCCTGCCAGTGGTTAAGCAAACAATGGTTTCAAAATTCAAGGTCCCCAAATGGCAGCATTTTAT
GTTCTGACCTGTTTGTGTTATATAGTGGTTTTTTTTTTCCTCTTTGGAACTCTTGTGTTGTTAATAAAATGAAATGATTACTTTTTAATT

>In-frame_ENST00000342374_ENST00000290231_TCGA-N8-A4PN_SERINC3_chr20_43139929_-_NCOA5_chr20_44691528_length(amino acids)=354AA_start in transcript=158_stop in transcript=1222
MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCD
VLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSGPISRQPLGATSGASLKTQPSS
QPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQ

--------------------------------------------------------------
>In-frame_ENST00000342374_ENST00000290231_TCGA-N8-A4PN-01A_SERINC3_chr20_43139929_-_NCOA5_chr20_44691527_length(transcript)=2538nt_BP=633nt
GGTGGGCGGGGCCACGCCGTGACGCATCCGTGCGTCTGTGGAAGGCTGCGTTTCCGGCCTGAGAAACCGTCATGTTTCTGGGGAGTCACC
TCAGCTGGCAGTTACCACCGTGTTAGAAAGCAGCCTCAGGACCGGCCACCTCCATCACTGGCGTCACCATGGGGGCTGTGCTGGGTGTCT
TCTCCCTCGCCAGCTGGGTTCCATGCCTCTGCAGCGGTGCCTCATGTTTGCTGTGTAGTTGCTGTCCTAACAGTAAGAATTCCACGGTGA
CTCGCCTCATTTATGCTTTCATTCTCCTCCTGAGCACTGTCGTATCCTATATCATGCAGAGAAAAGAGATGGAAACTTACTTGAAGAAGA
TTCCTGGATTTTGTGAAGGGGGATTTAAAATCCATGAGGCTGATATAAATGCAGATAAAGATTGTGATGTGCTGGTTGGTTATAAAGCTG
TGTATCGGATCAGCTTTGCCATGGCCATCTTTTTCTTTGTCTTTTCTCTGCTCATGTTCAAAGTAAAAACAAGTAAAGATCTCCGAGCGG
CAGTACACAATGGGTTTTGGTTCTTCAAAATTGCTGCCCTTATTGGAATCATGGTTGGCTCTTTCTACATCCCTGGGGGCTATTTCAGCT
CAGGCCCGATTTCCCGCCAACCACTCGGGGCGACCTCGGGTGCCTCGCTGAAGACACAGCCAAGCTCCCAACCGCTCCAGAGCGGCCAAG
TGCTCCCCTCTGCTACACCCACTCCATCTGCACCCCCCACCTCCCAGCAAGAGCTTCAGGCCAAAATCCTCAGCCTCTTCAATAGTGGCA
CAGTGACGGCCAATAGCAGCTCTGCATCCCCCTCGGTTGCTGCCGGAAACACCCCAAACCAGAATTTTTCCACAGCAGCAAACAGCCAGC
CTCAACAAAGATCACAGGCTTCTGGCAATCAGCCTCCAAGCATTTTGGGACAGGGAGGATCTGCTCAGAACATGGGCCCCAGACCTGGGG
CTCCTTCCCAAGGGCTTTTTGGCCAGCCTTCCAGTCGCCTGGCACCTGCTAGCAACATGACTAGCCAGAGGCCTGTGTCTTCCACAGGTA
TCAACTTTGACAATCCAAGTGTACAGAAGGCTCTGGATACCCTGATCCAGAGTGGCCCTGCTCTCTCCCACCTGGTTAGCCAGACCACAG
CACAGATGGGGCAGCCACAGGCCCCCATGGGATCTTACCAGAGGCATTACTGAAGCTAAATCTTTCAACTCTCCCCAGTCCCCTCATCCC
CTGGCCTCCTCCCACTTACTTGTTCTAAATAGAGCTGTTTGGAGGATGTTCTCTGCGCTCCCAGGCCGGCATCGAGTGTCATCAATTTCT
ACCACCTGCTCTCTCTTCTGCCCAAGGCTGTGTTGCTTATTCCTTACAAAGTTTATACTGCATTTGGGGCTGTATCTTTTTTTGTTTTTT
GTTTTGTAGAAAATAAATATCTCCGGGGGCAGTACAGGTGTCTGGGCTTGTATTTGATGGGGTTTCTCCGGTCCCTGTTTCTACTGGATT
TGGAGCCAGGCCCAGCTAGCCAAGTTTGGAATGGCATTTGTCATGTCAGTAGCCACCACCTTTGTTCATTGTGAACCTACCAAGGCTTTC
CAGCTTCATACACATTGACCAGAGCTCAAGCTCCTGCCTGCAACTCCTGCCTAGAGTTGAAGAAAAGCAAACTGGCCTTGGCAGGCACAG
TGTCATCATACCCTCACCCCATATGTTTGGGGTCTGCTTGAGGATTCATAAATCAGCCACTCTGGATTGTTGAGGAATGGCCATGGCAGC
CACAGAAAAAAGAATTTTTCTCTCTGAGCCAAGGTTGTTTTTTGTTTTTTTCTCTTTTCTTTTTTGTTTTCATTTCATTGGAAGATCTCC
AATGGACTGAACAGCTCCAGTCAGCAGCAGTTACCACAAACTGTGAATCTGGGCCCCACCACTCTTCCCTGTTAACCAGTTCTGTCAGCA
TCCCCCTCTCCAGCAGCACTTCCATGAAGTTGGTTCTGAGACTCTGGCCGTGAACACCCGTTTCTTCAGTGATTTGTTTTGGGCTTTTGG
CTCAAAACCCCAGGCTCTTGTTTTTGTCTAGACTCTTATTCTGTTTCCTGAGCAGCAGGAGGTAGGGACCACTTTGATGTCAGACTTCTG
GTAGCTGGACATGTTCTCGAGATGGGTGGCTGTTCGCGACTTTTGTACCAGAGTGAAATTGTTAGAAGGAGGGTTTCTGGCTGTGGTTCT
AAATGGAGCCCCAGGAAGCTGCCCTCTCCCCAGGGTTTGTGCTCAGTAGAGCCCTGTGGATCACAGTCTTGAGGTCCTCTAGCAGGGGTG
AGGGAGAGCAGCGACTTCAGCTGAGTCCCTGCCAGTGGTTAAGCAAACAATGGTTTCAAAATTCAAGGTCCCCAAATGGCAGCATTTTAT
GTTCTGACCTGTTTGTGTTATATAGTGGTTTTTTTTTTCCTCTTTGGAACTCTTGTGTTGTTAATAAAATGAAATGATTACTTTTTAATT

>In-frame_ENST00000342374_ENST00000290231_TCGA-N8-A4PN-01A_SERINC3_chr20_43139929_-_NCOA5_chr20_44691527_length(amino acids)=354AA_start in transcript=158_stop in transcript=1222
MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCD
VLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSGPISRQPLGATSGASLKTQPSS
QPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SERINC3-NCOA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SERINC3-NCOA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SERINC3-NCOA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERINC3C0033578Prostatic Neoplasms1CTD_human
HgeneSERINC3C0376358Malignant neoplasm of prostate1CTD_human