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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SERPINA1-TF (FusionGDB2 ID:80160)

Fusion Gene Summary for SERPINA1-TF

check button Fusion gene summary
Fusion gene informationFusion gene name: SERPINA1-TF
Fusion gene ID: 80160
HgeneTgene
Gene symbol

SERPINA1

TF

Gene ID

5265

7018

Gene nameserpin family A member 1transferrin
SynonymsA1A|A1AT|AAT|PI|PI1|PRO2275|alpha1AT|nNIFHEL-S-71p|PRO1557|PRO2086|TFQTL1
Cytomap

14q32.13

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-1-antitrypsinalpha-1 antitrypsinalpha-1 protease inhibitoralpha-1-antiproteinasealpha-1-antitrypsin nullalpha-1-antitrypsin short transcript variant 1C4alpha-1-antitrypsin short transcript variant 1C5epididymis secretory sperm binding proteinserotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilin
Modification date2020032720200313
UniProtAcc.

GTF2A1L

Ensembl transtripts involved in fusion geneENST00000440909, ENST00000448921, 
ENST00000437397, ENST00000355814, 
ENST00000393087, ENST00000393088, 
ENST00000404814, ENST00000449399, 
ENST00000402629, ENST00000555289, 
ENST00000402696, ENST00000264998, 
ENST00000475382, 
Fusion gene scores* DoF score28 X 24 X 6=40329 X 12 X 4=432
# samples 2813
** MAII scorelog2(28/4032*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/432*10)=-1.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERPINA1 [Title/Abstract] AND TF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSERPINA1(94848929)-TF(133472439), # samples:1
Anticipated loss of major functional domain due to fusion event.SERPINA1-TF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTF

GO:0048260

positive regulation of receptor-mediated endocytosis

12704209


check buttonFusion gene breakpoints across SERPINA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A73C-01ASERPINA1chr14

94848929

-TFchr3

133472439

+


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Fusion Gene ORF analysis for SERPINA1-TF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000440909ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000440909ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000440909ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
Frame-shiftENST00000448921ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000448921ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000448921ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
Frame-shiftENST00000437397ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000437397ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000437397ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
Frame-shiftENST00000355814ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000355814ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000355814ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
Frame-shiftENST00000393087ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000393087ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000393087ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
In-frameENST00000393088ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000393088ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000393088ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
In-frameENST00000404814ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000404814ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000404814ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
In-frameENST00000449399ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000449399ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000449399ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
Frame-shiftENST00000402629ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-5UTRENST00000402629ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
5CDS-3UTRENST00000402629ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+
intron-3CDSENST00000555289ENST00000402696SERPINA1chr14

94848929

-TFchr3

133472439

+
intron-5UTRENST00000555289ENST00000264998SERPINA1chr14

94848929

-TFchr3

133472439

+
intron-3UTRENST00000555289ENST00000475382SERPINA1chr14

94848929

-TFchr3

133472439

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393088SERPINA1chr1494848929-ENST00000402696TFchr3133472439+3468120112253081618
ENST00000404814SERPINA1chr1494848929-ENST00000402696TFchr3133472439+32249579812837618
ENST00000449399SERPINA1chr1494848929-ENST00000402696TFchr3133472439+32159489722828618

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393088ENST00000402696SERPINA1chr1494848929-TFchr3133472439+0.0035759270.996424
ENST00000404814ENST00000402696SERPINA1chr1494848929-TFchr3133472439+0.0036107760.99638927
ENST00000449399ENST00000402696SERPINA1chr1494848929-TFchr3133472439+0.0035967290.99640334

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Fusion Genomic Features for SERPINA1-TF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SERPINA1chr1494848928-TFchr3133472438+0.0003175540.9996824
SERPINA1chr1494848928-TFchr3133472438+0.0003175540.9996824

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SERPINA1-TF


check button Go to

FGviewer for the breakpoints of chr14:94848929-chr3:133472439

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TF

GTF2A1L

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.478

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTFchr14:94848929chr3:133472439ENST00000402696117361_68372.0699.0DomainTransferrin-like 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000355814-25368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000393087-25368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000393088-47368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000402629-24368_392215.33333333333334360.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000404814-36368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000437397-36368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000440909-25368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000448921-47368_392215.33333333333334419.0RegionNote=RCL
HgeneSERPINA1chr14:94848929chr3:133472439ENST00000449399-36368_392215.33333333333334419.0RegionNote=RCL
TgeneTFchr14:94848929chr3:133472439ENST0000040269611725_34772.0699.0DomainTransferrin-like 1


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Fusion Gene Sequence for SERPINA1-TF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393088_ENST00000402696_TCGA-DD-A73C-01A_SERPINA1_chr14_94848929_-_TF_chr3_133472439_length(transcript)=3468nt_BP=1201nt
GTGGGCAGGAACTGGGCACTGTGCCCAGGGCATGCACTGCCTCCACGCAGCAACCCTCAGAGTCCTGAGCTGAACCAAGAAGGAGGAGGG
GGTCGGGCCTCCGAGGAAGGCCTAGCCGCTGCTGCTGCCAGGAATTCCAGGTTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACT
CTCCTGTGCCTGCCAGAAGAGACAGAGCTTGAGGAGAGCTTGAGGAGAGCAGGAAAGGGCGGCAGTAAGTCTTCAGCATCAGGCATTTTG
GGGTGACTCAGTAAATGGTAGATCTTGCTACCAGTGGAACAGCCACTAAGGATTCTGCAGTGAGAGCAGAGGGCCAGCTAAGTGGTACTC
TCCCAGAGACTGTCTGACTCACGCCACCCCCTCCACCTTGGACACAGGACGCTGTGGTTTCTGAGCCAGGTACAATGACTCCTTTCGCAG
CCTCCCCCGTTGCCCCTCTGGATCCACTGCTTAAATACGGACGAGGACAGGGCCCTGTCTCCTCAGCTTCAGGCACCACCACTGACCTGG
GACAGTGAATCGACAATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGTGCTGCCTGGTCCCTGTCTCCCTGGCTGAG
GATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCTTCAACAAGATCACCCCCAACCTGGCT
GAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCTCCCCAGTGAGCATCGCTACAGCCTTT
GCAATGCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCAACCTCACGGAGATTCCGGAGGCTCAG
ATCCATGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGACCACCGGCAATGGCCTGTTCCTCAGC
GAGGGCCTGAAGCTAGTGGATAAGTTTTTGGAGGATGTTAAAAAGTTGTACCACTCAGAAGCCTTCACTGTCAACTTCGGGGACACCGAA
GAGGCCAAGAAACAGATCAACGATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGCTTGACAGAGACACAGTT
TTTGCTCTGGTGAATTACATCTTCTTTAAAGGCAAACGAAGCGGATGCTGTGACACTGGATGCAGGTTTGGTGTATGATGCTTACCTGGC
TCCCAATAACCTGAAGCCTGTGGTGGCAGAGTTCTATGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCTGTTGCTGTGGTGAAGAA
GGATAGTGGCTTCCAGATGAACCAGCTTCGAGGCAAGAAGTCCTGCCACACGGGTCTAGGCAGGTCCGCTGGGTGGAACATCCCCATAGG
CTTACTTTACTGTGACTTACCTGAGCCACGTAAACCTCTTGAGAAAGCAGTGGCCAATTTCTTCTCGGGCAGCTGTGCCCCTTGTGCGGA
TGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACCCTTAACCAATACTTCGGCTACTCGGGAGCCTTCAA
GTGTCTGAAGGATGGTGCTGGGGATGTGGCCTTTGTCAAGCACTCGACTATATTTGAGAACTTGGCAAACAAGGCTGACAGGGACCAGTA
TGAGCTGCTTTGCCTGGACAACACCCGGAAGCCGGTAGATGAATACAAGGACTGCCACTTGGCCCAGGTCCCTTCTCATACCGTCGTGGC
CCGAAGTATGGGCGGCAAGGAGGACTTGATCTGGGAGCTTCTCAACCAGGCCCAGGAACATTTTGGCAAAGACAAATCAAAAGAATTCCA
ACTATTCAGCTCTCCTCATGGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGGTTTTTAAAAGTCCCCCCCAGGATGGATGCCAAGAT
GTACCTGGGCTATGAGTATGTCACTGCCATCCGGAATCTACGGGAAGGCACATGCCCAGAAGCCCCAACAGATGAATGCAAGCCTGTGAA
GTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGTGTTAACAGTGTAGGGAAAATAGAGTGTGTATCAGCAGAGAC
CACCGAAGACTGCATCGCCAAGATCATGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTACATAGCGGGCAAGTGTGG
TCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTTGCTATAGCAGTGGTGAA
GAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACCGCTGGCTGGAACATCCC
CATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGGTCTAAGAAAGACTCCAG
TCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTACACAGGCGCTTTCAGGTG
TCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCTGATCCATGGGCTAAGAA
TCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGCCACCTGGCCAGAGCCCC
GAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTATTTGGAAGCAACGTAAC
TGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGTTTGGCCAAACTTCATGA
CAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACCTCATCACTCCTGGAAGC
CTGCACTTTCCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACCAAGGTGAAGATGGGAACGCAGATGATCCATGAGTTTGCCCTGGT
TTCACTGGCCCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCTGAACAAAAAATAAAAATTATTATT
GATTTTATATTTCAAAAACTCCATTCTTTCCTAAATATTTTCAACAAAGGATTTCTTTATGCATTCTGCCTAAATACCTATGCAACTGAG
CCCTTCCTTCTCAGCTCAAGATTCGTCTGGTCTTTCCCTACAGCTTTGTGTGTGCCATGGCCACATCTCCTGGGTACAGTTCAAGGAGAC

>In-frame_ENST00000393088_ENST00000402696_TCGA-DD-A73C-01A_SERPINA1_chr14_94848929_-_TF_chr3_133472439_length(amino acids)=618AA_start in transcript=1225_stop in transcript=3081
MDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVA
NFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDC
HLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
PEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDT
PEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNK
EGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKIL

--------------------------------------------------------------
>In-frame_ENST00000404814_ENST00000402696_TCGA-DD-A73C-01A_SERPINA1_chr14_94848929_-_TF_chr3_133472439_length(transcript)=3224nt_BP=957nt
ATGCACTGCCTCCACGCAGCAACCCTCAGAGTCCTGAGCTGAACCAAGAAGGAGGAGGGGGTCGGGCCTCCGAGGAAGGCCTAGCCGCTG
CTGCTGCCAGGAATTCCAGGTTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACTCTCCTGTGCCTGCCAGAAGAGACAGAGCTTG
AGGAGAGCTTGAGGAGAGCAGGAAAGCCTCCCCCGTTGCCCCTCTGGATCCACTGCTTAAATACGGACGAGGACAGGGCCCTGTCTCCTC
AGCTTCAGGCACCACCACTGACCTGGGACAGTGAATCGACAATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGTGCT
GCCTGGTCCCTGTCTCCCTGGCTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCT
TCAACAAGATCACCCCCAACCTGGCTGAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCT
CCCCAGTGAGCATCGCTACAGCCTTTGCAATGCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCA
ACCTCACGGAGATTCCGGAGGCTCAGATCCATGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGA
CCACCGGCAATGGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGATAAGTTTTTGGAGGATGTTAAAAAGTTGTACCACTCAGAAGCCT
TCACTGTCAACTTCGGGGACACCGAAGAGGCCAAGAAACAGATCAACGATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGG
TCAAGGAGCTTGACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAGGCAAACGAAGCGGATGCTGTGACACTGGATGCA
GGTTTGGTGTATGATGCTTACCTGGCTCCCAATAACCTGAAGCCTGTGGTGGCAGAGTTCTATGGGTCAAAAGAGGATCCACAGACTTTC
TATTATGCTGTTGCTGTGGTGAAGAAGGATAGTGGCTTCCAGATGAACCAGCTTCGAGGCAAGAAGTCCTGCCACACGGGTCTAGGCAGG
TCCGCTGGGTGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAGCCACGTAAACCTCTTGAGAAAGCAGTGGCCAATTTCTTC
TCGGGCAGCTGTGCCCCTTGTGCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACCCTTAACCAA
TACTTCGGCTACTCGGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGATGTGGCCTTTGTCAAGCACTCGACTATATTTGAGAACTTG
GCAAACAAGGCTGACAGGGACCAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGCCGGTAGATGAATACAAGGACTGCCACTTGGCC
CAGGTCCCTTCTCATACCGTCGTGGCCCGAAGTATGGGCGGCAAGGAGGACTTGATCTGGGAGCTTCTCAACCAGGCCCAGGAACATTTT
GGCAAAGACAAATCAAAAGAATTCCAACTATTCAGCTCTCCTCATGGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGGTTTTTAAAA
GTCCCCCCCAGGATGGATGCCAAGATGTACCTGGGCTATGAGTATGTCACTGCCATCCGGAATCTACGGGAAGGCACATGCCCAGAAGCC
CCAACAGATGAATGCAAGCCTGTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGTGTTAACAGTGTAGGG
AAAATAGAGTGTGTATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATCATGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGG
TTTGTCTACATAGCGGGCAAGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCA
GGGTATTTTGCTATAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTT
GGCAGAACCGCTGGCTGGAACATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGT
GCCCCTGGGTCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATAC
TACGGCTACACAGGCGCTTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGA
AAAAACCCTGATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTAT
GCGAACTGCCACCTGGCCAGAGCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAG
CAGCACCTATTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGAC
ACAGTATGTTTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAA
TGCTCCACCTCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACCAAGGTGAAGATGGGAACG
CAGATGATCCATGAGTTTGCCCTGGTTTCACTGGCCCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTG
CTGAACAAAAAATAAAAATTATTATTGATTTTATATTTCAAAAACTCCATTCTTTCCTAAATATTTTCAACAAAGGATTTCTTTATGCAT
TCTGCCTAAATACCTATGCAACTGAGCCCTTCCTTCTCAGCTCAAGATTCGTCTGGTCTTTCCCTACAGCTTTGTGTGTGCCATGGCCAC

>In-frame_ENST00000404814_ENST00000402696_TCGA-DD-A73C-01A_SERPINA1_chr14_94848929_-_TF_chr3_133472439_length(amino acids)=618AA_start in transcript=981_stop in transcript=2837
MDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVA
NFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDC
HLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
PEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDT
PEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNK
EGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKIL

--------------------------------------------------------------
>In-frame_ENST00000449399_ENST00000402696_TCGA-DD-A73C-01A_SERPINA1_chr14_94848929_-_TF_chr3_133472439_length(transcript)=3215nt_BP=948nt
CACGCAGCAACCCTCAGAGTCCTGAGCTGAACCAAGAAGGAGGAGGGGGTCGGGCCTCCGAGGAAGGCCTAGCCGCTGCTGCTGCCAGGA
ATTCCAGGTTGGAGGGGCGGCAACCTCCTGCCAGCCTTCAGGCCACTCTCCTGTGCCTGCCAGAAGAGACAGAGCTTGAGGAGAGCTTGA
GGAGAGCAGGAAAGCAGCCTCCCCCGTTGCCCCTCTGGATCCACTGCTTAAATACGGACGAGGACAGGGCCCTGTCTCCTCAGCTTCAGG
CACCACCACTGACCTGGGACAGTGAATCGACAATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGTGCTGCCTGGTCC
CTGTCTCCCTGGCTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCATGATCAGGATCACCCAACCTTCAACAAGA
TCACCCCCAACCTGGCTGAGTTCGCCTTCAGCCTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCTCCCCAGTGA
GCATCGCTACAGCCTTTGCAATGCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATCCTGGAGGGCCTGAATTTCAACCTCACGG
AGATTCCGGAGGCTCAGATCCATGAAGGCTTCCAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGACCACCGGCA
ATGGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGATAAGTTTTTGGAGGATGTTAAAAAGTTGTACCACTCAGAAGCCTTCACTGTCA
ACTTCGGGGACACCGAAGAGGCCAAGAAACAGATCAACGATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGC
TTGACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAGGCAAACGAAGCGGATGCTGTGACACTGGATGCAGGTTTGGTG
TATGATGCTTACCTGGCTCCCAATAACCTGAAGCCTGTGGTGGCAGAGTTCTATGGGTCAAAAGAGGATCCACAGACTTTCTATTATGCT
GTTGCTGTGGTGAAGAAGGATAGTGGCTTCCAGATGAACCAGCTTCGAGGCAAGAAGTCCTGCCACACGGGTCTAGGCAGGTCCGCTGGG
TGGAACATCCCCATAGGCTTACTTTACTGTGACTTACCTGAGCCACGTAAACCTCTTGAGAAAGCAGTGGCCAATTTCTTCTCGGGCAGC
TGTGCCCCTTGTGCGGATGGGACGGACTTCCCCCAGCTGTGTCAACTGTGTCCAGGGTGTGGCTGCTCCACCCTTAACCAATACTTCGGC
TACTCGGGAGCCTTCAAGTGTCTGAAGGATGGTGCTGGGGATGTGGCCTTTGTCAAGCACTCGACTATATTTGAGAACTTGGCAAACAAG
GCTGACAGGGACCAGTATGAGCTGCTTTGCCTGGACAACACCCGGAAGCCGGTAGATGAATACAAGGACTGCCACTTGGCCCAGGTCCCT
TCTCATACCGTCGTGGCCCGAAGTATGGGCGGCAAGGAGGACTTGATCTGGGAGCTTCTCAACCAGGCCCAGGAACATTTTGGCAAAGAC
AAATCAAAAGAATTCCAACTATTCAGCTCTCCTCATGGGAAGGACCTGCTGTTTAAGGACTCTGCCCACGGGTTTTTAAAAGTCCCCCCC
AGGATGGATGCCAAGATGTACCTGGGCTATGAGTATGTCACTGCCATCCGGAATCTACGGGAAGGCACATGCCCAGAAGCCCCAACAGAT
GAATGCAAGCCTGTGAAGTGGTGTGCGCTGAGCCACCACGAGAGGCTCAAGTGTGATGAGTGGAGTGTTAACAGTGTAGGGAAAATAGAG
TGTGTATCAGCAGAGACCACCGAAGACTGCATCGCCAAGATCATGAATGGAGAAGCTGATGCCATGAGCTTGGATGGAGGGTTTGTCTAC
ATAGCGGGCAAGTGTGGTCTGGTGCCTGTCTTGGCAGAAAACTACAATAAGAGCGATAATTGTGAGGATACACCAGAGGCAGGGTATTTT
GCTATAGCAGTGGTGAAGAAATCAGCTTCTGACCTCACCTGGGACAATCTGAAAGGCAAGAAGTCCTGCCATACGGCAGTTGGCAGAACC
GCTGGCTGGAACATCCCCATGGGCCTGCTCTACAATAAGATCAACCACTGCAGATTTGATGAATTTTTCAGTGAAGGTTGTGCCCCTGGG
TCTAAGAAAGACTCCAGTCTCTGTAAGCTGTGTATGGGCTCAGGCCTAAACCTGTGTGAACCCAACAACAAAGAGGGATACTACGGCTAC
ACAGGCGCTTTCAGGTGTCTGGTTGAGAAGGGAGATGTGGCCTTTGTGAAACACCAGACTGTCCCACAGAACACTGGGGGAAAAAACCCT
GATCCATGGGCTAAGAATCTGAATGAAAAAGACTATGAGTTGCTGTGCCTTGATGGTACCAGGAAACCTGTGGAGGAGTATGCGAACTGC
CACCTGGCCAGAGCCCCGAATCACGCTGTGGTCACACGGAAAGATAAGGAAGCTTGCGTCCACAAGATATTACGTCAACAGCAGCACCTA
TTTGGAAGCAACGTAACTGACTGCTCGGGCAACTTTTGTTTGTTCCGGTCGGAAACCAAGGACCTTCTGTTCAGAGATGACACAGTATGT
TTGGCCAAACTTCATGACAGAAACACATATGAAAAATACTTAGGAGAAGAATATGTCAAGGCTGTTGGTAACCTGAGAAAATGCTCCACC
TCATCACTCCTGGAAGCCTGCACTTTCCGTAGACCTTAAAATCTCAGAGGTAGGGCTGCCACCAAGGTGAAGATGGGAACGCAGATGATC
CATGAGTTTGCCCTGGTTTCACTGGCCCAAGTGGTTTGTGCTAACCACGTCTGTCTTCACAGCTCTGTGTTGCCATGTGTGCTGAACAAA
AAATAAAAATTATTATTGATTTTATATTTCAAAAACTCCATTCTTTCCTAAATATTTTCAACAAAGGATTTCTTTATGCATTCTGCCTAA
ATACCTATGCAACTGAGCCCTTCCTTCTCAGCTCAAGATTCGTCTGGTCTTTCCCTACAGCTTTGTGTGTGCCATGGCCACATCTCCTGG

>In-frame_ENST00000449399_ENST00000402696_TCGA-DD-A73C-01A_SERPINA1_chr14_94848929_-_TF_chr3_133472439_length(amino acids)=618AA_start in transcript=972_stop in transcript=2828
MDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVA
NFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDC
HLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTC
PEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDT
PEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNK
EGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKIL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SERPINA1-TF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SERPINA1-TF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SERPINA1-TF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERPINA1C0023895Liver diseases6CTD_human
HgeneSERPINA1C0086565Liver Dysfunction6CTD_human
HgeneSERPINA1C0221757alpha 1-Antitrypsin Deficiency6CTD_human;GENOMICS_ENGLAND
HgeneSERPINA1C0023890Liver Cirrhosis3CTD_human
HgeneSERPINA1C0239946Fibrosis, Liver3CTD_human
HgeneSERPINA1C0005586Bipolar Disorder2CTD_human;PSYGENET
HgeneSERPINA1C0024117Chronic Obstructive Airway Disease2CTD_human
HgeneSERPINA1C0030328Panniculitis, Nodular Nonsuppurative2CTD_human
HgeneSERPINA1C0525045Mood Disorders2PSYGENET
HgeneSERPINA1C1527303Chronic Airflow Obstruction2CTD_human
HgeneSERPINA1C2239176Liver carcinoma2CTD_human
HgeneSERPINA1C0001418Adenocarcinoma1CTD_human
HgeneSERPINA1C0003469Anxiety Disorders1CTD_human
HgeneSERPINA1C0003850Arteriosclerosis1CTD_human
HgeneSERPINA1C0003949Asbestosis1CTD_human
HgeneSERPINA1C0005587Depression, Bipolar1CTD_human
HgeneSERPINA1C0006267Bronchiectasis1CTD_human
HgeneSERPINA1C0008370Cholestasis1CTD_human
HgeneSERPINA1C0013221Drug toxicity1CTD_human
HgeneSERPINA1C0013990Pathological accumulation of air in tissues1CTD_human
HgeneSERPINA1C0019080Hemorrhage1CTD_human
HgeneSERPINA1C0019693HIV Infections1CTD_human
HgeneSERPINA1C0020615Hypoglycemia1CTD_human
HgeneSERPINA1C0022660Kidney Failure, Acute1CTD_human
HgeneSERPINA1C0024115Lung diseases1CTD_human;GENOMICS_ENGLAND
HgeneSERPINA1C0024121Lung Neoplasms1CTD_human
HgeneSERPINA1C0024623Malignant neoplasm of stomach1CTD_human
HgeneSERPINA1C0024713Manic Disorder1CTD_human
HgeneSERPINA1C0027627Neoplasm Metastasis1CTD_human
HgeneSERPINA1C0034067Pulmonary Emphysema1CTD_human
HgeneSERPINA1C0034069Pulmonary Fibrosis1CTD_human
HgeneSERPINA1C0038356Stomach Neoplasms1CTD_human
HgeneSERPINA1C0039841Thiamine Deficiency1CTD_human
HgeneSERPINA1C0041755Adverse reaction to drug1CTD_human
HgeneSERPINA1C0042384Vasculitis1CTD_human
HgeneSERPINA1C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneSERPINA1C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneSERPINA1C0205643Carcinoma, Cribriform1CTD_human
HgeneSERPINA1C0205644Carcinoma, Granular Cell1CTD_human
HgeneSERPINA1C0205645Adenocarcinoma, Tubular1CTD_human
HgeneSERPINA1C0221227Centriacinar Emphysema1CTD_human
HgeneSERPINA1C0242379Malignant neoplasm of lung1CTD_human
HgeneSERPINA1C0264393Panacinar Emphysema1CTD_human
HgeneSERPINA1C0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneSERPINA1C0271708Fasting Hypoglycemia1CTD_human
HgeneSERPINA1C0271710Reactive hypoglycemia1CTD_human
HgeneSERPINA1C0338831Manic1CTD_human
HgeneSERPINA1C0376280Anxiety States, Neurotic1CTD_human
HgeneSERPINA1C0524851Neurodegenerative Disorders1CTD_human
HgeneSERPINA1C0751733Degenerative Diseases, Spinal Cord1CTD_human
HgeneSERPINA1C1279420Anxiety neurosis (finding)1CTD_human
HgeneSERPINA1C1565662Acute Kidney Insufficiency1CTD_human
HgeneSERPINA1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneSERPINA1C2350878Focal Emphysema1CTD_human
HgeneSERPINA1C2609414Acute kidney injury1CTD_human
HgeneSERPINA1C2930617Pulmonary Fibrosis - from Asbestos Exposure1CTD_human
HgeneSERPINA1C2930967Gastro-enteropancreatic neuroendocrine tumor1CTD_human
HgeneSERPINA1C4505456HIV Coinfection1CTD_human
HgeneSERPINA1C4721507Alveolitis, Fibrosing1CTD_human
TgeneTFC0521802Congenital atransferrinemia5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneTFC0036341Schizophrenia3PSYGENET
TgeneTFC0001956Alcohol Use Disorder2CTD_human
TgeneTFC0001973Alcoholic Intoxication, Chronic2CTD_human
TgeneTFC0002395Alzheimer's Disease2CTD_human
TgeneTFC0007097Carcinoma2CTD_human
TgeneTFC0011265Presenile dementia2CTD_human
TgeneTFC0015695Fatty Liver2CTD_human
TgeneTFC0024667Animal Mammary Neoplasms2CTD_human
TgeneTFC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneTFC0085762Alcohol abuse2CTD_human
TgeneTFC0205696Anaplastic carcinoma2CTD_human
TgeneTFC0205697Carcinoma, Spindle-Cell2CTD_human
TgeneTFC0205698Undifferentiated carcinoma2CTD_human
TgeneTFC0205699Carcinomatosis2CTD_human
TgeneTFC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgeneTFC0494463Alzheimer Disease, Late Onset2CTD_human
TgeneTFC0546126Acute Confusional Senile Dementia2CTD_human
TgeneTFC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgeneTFC0750901Alzheimer Disease, Early Onset2CTD_human
TgeneTFC1257925Mammary Carcinoma, Animal2CTD_human
TgeneTFC2711227Steatohepatitis2CTD_human
TgeneTFC0004352Autistic Disorder1CTD_human
TgeneTFC0013221Drug toxicity1CTD_human
TgeneTFC0013502Echinococcosis1CTD_human
TgeneTFC0019158Hepatitis1CTD_human
TgeneTFC0019193Hepatitis, Toxic1CTD_human
TgeneTFC0021368Inflammation1CTD_human
TgeneTFC0022660Kidney Failure, Acute1CTD_human
TgeneTFC0027626Neoplasm Invasiveness1CTD_human
TgeneTFC0027726Nephrotic Syndrome1CTD_human
TgeneTFC0028754Obesity1CTD_human
TgeneTFC0030524Paratuberculosis1CTD_human
TgeneTFC0035258Restless Legs Syndrome1CTD_human
TgeneTFC0041755Adverse reaction to drug1CTD_human
TgeneTFC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneTFC0271901Microcytic hypochromic anemia (disorder)1CTD_human
TgeneTFC0282193Iron Overload1CTD_human
TgeneTFC0345967Malignant mesothelioma1CTD_human
TgeneTFC0860207Drug-Induced Liver Disease1CTD_human
TgeneTFC1262760Hepatitis, Drug-Induced1CTD_human
TgeneTFC1565662Acute Kidney Insufficiency1CTD_human
TgeneTFC2609414Acute kidney injury1CTD_human
TgeneTFC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneTFC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneTFC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneTFC4553297Cystic Echinocccosis1CTD_human