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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SERTAD2-TGFA (FusionGDB2 ID:80249)

Fusion Gene Summary for SERTAD2-TGFA

check button Fusion gene summary
Fusion gene informationFusion gene name: SERTAD2-TGFA
Fusion gene ID: 80249
HgeneTgene
Gene symbol

SERTAD2

TGFA

Gene ID

9792

7039

Gene nameSERTA domain containing 2transforming growth factor alpha
SynonymsSei-2|TRIP-Br2|TRIPBR2TFGA
Cytomap

2p14

2p13.3

Type of geneprotein-codingprotein-coding
DescriptionSERTA domain-containing protein 2transcriptional regulator interacting with the PHD-bromodomain 2transcriptional regulator interacting with the PHS-bromodomain 2protransforming growth factor alphaTGF-alpha
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313349, ENST00000476805, 
ENST00000295400, ENST00000445399, 
ENST00000418333, ENST00000450929, 
ENST00000444975, ENST00000460808, 
Fusion gene scores* DoF score3 X 1 X 3=94 X 3 X 3=36
# samples 45
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SERTAD2 [Title/Abstract] AND TGFA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSERTAD2(64977415)-TGFA(70692865), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERTAD2

GO:0030308

negative regulation of cell growth

16098148

TgeneTGFA

GO:0000187

activation of MAPK activity

11278323

TgeneTGFA

GO:0045741

positive regulation of epidermal growth factor-activated receptor activity

11278323

TgeneTGFA

GO:0045840

positive regulation of mitotic nuclear division

11278323

TgeneTGFA

GO:0050679

positive regulation of epithelial cell proliferation

11278323


check buttonFusion gene breakpoints across SERTAD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TGFA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-7069-01ASERTAD2chr2

64977415

-TGFAchr2

70692865

-
ChimerDB4HNSCTCGA-CQ-7069SERTAD2chr2

64977415

-TGFAchr2

70692865

-
ChimerDB4HNSCTCGA-CQ-7069SERTAD2chr2

64977415

-TGFAchr2

70692868

-


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Fusion Gene ORF analysis for SERTAD2-TGFA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000313349ENST00000295400SERTAD2chr2

64977415

-TGFAchr2

70692865

-
intron-3CDSENST00000313349ENST00000445399SERTAD2chr2

64977415

-TGFAchr2

70692865

-
intron-3CDSENST00000313349ENST00000418333SERTAD2chr2

64977415

-TGFAchr2

70692865

-
intron-3CDSENST00000313349ENST00000450929SERTAD2chr2

64977415

-TGFAchr2

70692865

-
intron-3CDSENST00000313349ENST00000444975SERTAD2chr2

64977415

-TGFAchr2

70692865

-
intron-5UTRENST00000313349ENST00000460808SERTAD2chr2

64977415

-TGFAchr2

70692865

-
5UTR-3CDSENST00000476805ENST00000295400SERTAD2chr2

64977415

-TGFAchr2

70692865

-
5UTR-3CDSENST00000476805ENST00000445399SERTAD2chr2

64977415

-TGFAchr2

70692865

-
5UTR-3CDSENST00000476805ENST00000418333SERTAD2chr2

64977415

-TGFAchr2

70692865

-
5UTR-3CDSENST00000476805ENST00000450929SERTAD2chr2

64977415

-TGFAchr2

70692865

-
5UTR-3CDSENST00000476805ENST00000444975SERTAD2chr2

64977415

-TGFAchr2

70692865

-
5UTR-5UTRENST00000476805ENST00000460808SERTAD2chr2

64977415

-TGFAchr2

70692865

-
intron-3CDSENST00000313349ENST00000295400SERTAD2chr2

64977415

-TGFAchr2

70692868

-
intron-3CDSENST00000313349ENST00000445399SERTAD2chr2

64977415

-TGFAchr2

70692868

-
intron-3CDSENST00000313349ENST00000418333SERTAD2chr2

64977415

-TGFAchr2

70692868

-
intron-3CDSENST00000313349ENST00000450929SERTAD2chr2

64977415

-TGFAchr2

70692868

-
intron-3CDSENST00000313349ENST00000444975SERTAD2chr2

64977415

-TGFAchr2

70692868

-
intron-5UTRENST00000313349ENST00000460808SERTAD2chr2

64977415

-TGFAchr2

70692868

-
5UTR-3CDSENST00000476805ENST00000295400SERTAD2chr2

64977415

-TGFAchr2

70692868

-
5UTR-3CDSENST00000476805ENST00000445399SERTAD2chr2

64977415

-TGFAchr2

70692868

-
5UTR-3CDSENST00000476805ENST00000418333SERTAD2chr2

64977415

-TGFAchr2

70692868

-
5UTR-3CDSENST00000476805ENST00000450929SERTAD2chr2

64977415

-TGFAchr2

70692868

-
5UTR-3CDSENST00000476805ENST00000444975SERTAD2chr2

64977415

-TGFAchr2

70692868

-
5UTR-5UTRENST00000476805ENST00000460808SERTAD2chr2

64977415

-TGFAchr2

70692868

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SERTAD2-TGFA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SERTAD2-TGFA


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SERTAD2-TGFA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SERTAD2-TGFA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SERTAD2-TGFA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SERTAD2-TGFA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTGFAC2239176Liver carcinoma2CTD_human
TgeneTGFAC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneTGFAC0018671Head and Neck Neoplasms1CTD_human
TgeneTGFAC0018675Head Neoplasms1CTD_human
TgeneTGFAC0019207Hepatoma, Morris1CTD_human
TgeneTGFAC0019208Hepatoma, Novikoff1CTD_human
TgeneTGFAC0020542Pulmonary Hypertension1CTD_human
TgeneTGFAC0021368Inflammation1CTD_human
TgeneTGFAC0023903Liver neoplasms1CTD_human
TgeneTGFAC0023904Liver Neoplasms, Experimental1CTD_human
TgeneTGFAC0024623Malignant neoplasm of stomach1CTD_human
TgeneTGFAC0024667Animal Mammary Neoplasms1CTD_human
TgeneTGFAC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneTGFAC0027533Neck Neoplasms1CTD_human
TgeneTGFAC0027746Nerve Degeneration1CTD_human
TgeneTGFAC0030246Pustulosis of Palms and Soles1CTD_human
TgeneTGFAC0030354Papilloma1CTD_human
TgeneTGFAC0033578Prostatic Neoplasms1CTD_human
TgeneTGFAC0033860Psoriasis1CTD_human
TgeneTGFAC0034063Pulmonary Edema1CTD_human
TgeneTGFAC0034069Pulmonary Fibrosis1CTD_human
TgeneTGFAC0038356Stomach Neoplasms1CTD_human
TgeneTGFAC0086404Experimental Hepatoma1CTD_human
TgeneTGFAC0162770Right Ventricular Hypertrophy1CTD_human
TgeneTGFAC0205874Papilloma, Squamous Cell1CTD_human
TgeneTGFAC0205875Papillomatosis1CTD_human
TgeneTGFAC0206624Hepatoblastoma1CTD_human
TgeneTGFAC0273115Lung Injury1CTD_human
TgeneTGFAC0278996Malignant Head and Neck Neoplasm1CTD_human
TgeneTGFAC0333355Inflammatory disease of mucous membrane1CTD_human
TgeneTGFAC0345904Malignant neoplasm of liver1CTD_human
TgeneTGFAC0376358Malignant neoplasm of prostate1CTD_human
TgeneTGFAC0746787Cancer of Neck1CTD_human
TgeneTGFAC0751177Cancer of Head1CTD_human
TgeneTGFAC0887900Upper Aerodigestive Tract Neoplasms1CTD_human
TgeneTGFAC1257925Mammary Carcinoma, Animal1CTD_human
TgeneTGFAC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneTGFAC2350344Chronic Lung Injury1CTD_human
TgeneTGFAC3711374Nonsyndromic Deafness1CTD_human
TgeneTGFAC4721507Alveolitis, Fibrosing1CTD_human