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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SF1-CST6 (FusionGDB2 ID:80433)

Fusion Gene Summary for SF1-CST6

check button Fusion gene summary
Fusion gene informationFusion gene name: SF1-CST6
Fusion gene ID: 80433
HgeneTgene
Gene symbol

SF1

CST6

Gene ID

7536

1476

Gene namesplicing factor 1cystatin B
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162CPI-B|CST6|EPM1|EPM1A|PME|STFB|ULD
Cytomap

11q13.1

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162cystatin-Bcystatin B (stefin B)epididymis secretory sperm binding proteinliver thiol proteinase inhibitor
Modification date2020031820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377387, ENST00000377390, 
ENST00000377394, ENST00000227503, 
ENST00000334944, ENST00000422298, 
ENST00000433274, ENST00000489544, 
ENST00000312134, 
Fusion gene scores* DoF score21 X 11 X 13=30032 X 2 X 1=4
# samples 263
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/4*10)=2.90689059560852
Context

PubMed: SF1 [Title/Abstract] AND CST6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSF1(64545834)-CST6(65779657), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCST6

GO:0010466

negative regulation of peptidase activity

6203523

TgeneCST6

GO:0045861

negative regulation of proteolysis

3488317


check buttonFusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CST6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1489-01ASF1chr11

64545834

-CST6chr11

65779657

+
ChimerDB4OVTCGA-13-1489-02ASF1chr11

64545834

-CST6chr11

65779657

+
ChimerDB4OVTCGA-13-1489-01ASF1chr11

64545834

-CST6chr11

65779657

+
ChimerDB4OVTCGA-13-1489-02ASF1chr11

64545458

-CST6chr11

65779656

+
ChimerDB4OVTCGA-13-1489-02ASF1chr11

64545833

-CST6chr11

65779656

+


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Fusion Gene ORF analysis for SF1-CST6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000377387ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
In-frameENST00000377390ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
In-frameENST00000377394ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
In-frameENST00000227503ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
In-frameENST00000334944ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
5UTR-3CDSENST00000422298ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
intron-3CDSENST00000433274ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
intron-3CDSENST00000489544ENST00000312134SF1chr11

64545834

-CST6chr11

65779657

+
In-frameENST00000377387ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000377390ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000377394ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000227503ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000334944ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000422298ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000433274ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000489544ENST00000312134SF1chr11

64545458

-CST6chr11

65779656

+
intron-3CDSENST00000377387ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
In-frameENST00000377390ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
In-frameENST00000377394ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
In-frameENST00000227503ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
In-frameENST00000334944ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
5UTR-3CDSENST00000422298ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
intron-3CDSENST00000433274ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+
intron-3CDSENST00000489544ENST00000312134SF1chr11

64545833

-CST6chr11

65779656

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377390SF1chr1164545834-ENST00000312134CST6chr1165779657+78236964659195
ENST00000377394SF1chr1164545834-ENST00000312134CST6chr1165779657+79938666376195
ENST00000227503SF1chr1164545834-ENST00000312134CST6chr1165779657+79938666376195
ENST00000334944SF1chr1164545834-ENST00000312134CST6chr1165779657+838425702115195
ENST00000377387SF1chr1164545458-ENST00000312134CST6chr1165779656+8974837610254
ENST00000377390SF1chr1164545833-ENST00000312134CST6chr1165779656+7833696470216
ENST00000377394SF1chr1164545833-ENST00000312134CST6chr1165779656+8003866642221
ENST00000227503SF1chr1164545833-ENST00000312134CST6chr1165779656+8003866642221
ENST00000334944SF1chr1164545833-ENST00000312134CST6chr1165779656+83942570311230

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377390ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0145291810.9854708
ENST00000377394ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0227122270.97728777
ENST00000227503ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0227122270.97728777
ENST00000334944ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0225714780.9774285
ENST00000377387ENST00000312134SF1chr1164545458-CST6chr1165779656+0.0441414970.9558585
ENST00000377390ENST00000312134SF1chr1164545833-CST6chr1165779656+0.0335589160.9664411
ENST00000377394ENST00000312134SF1chr1164545833-CST6chr1165779656+0.37364060.6263594
ENST00000227503ENST00000312134SF1chr1164545833-CST6chr1165779656+0.37364060.6263594
ENST00000334944ENST00000312134SF1chr1164545833-CST6chr1165779656+0.381785750.6182142

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Fusion Genomic Features for SF1-CST6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SF1-CST6


check button Go to

FGviewer for the breakpoints of chr11:64545834-chr11:65779657

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-11315_19135.33333333333334674.0MotifNuclear localization signal
TgeneCST6chr11:64545458chr11:65779656ENST000003121340380_840150.0MotifNote=Secondary area of contact
TgeneCST6chr11:64545833chr11:65779656ENST000003121340380_840150.0MotifNote=Secondary area of contact
TgeneCST6chr11:64545834chr11:65779657ENST000003121340380_840150.0MotifNote=Secondary area of contact

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-113324_6370549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-114324_6370639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-113324_637135.33333333333334674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-113324_6370640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-113324_6370572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-113324_6370614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-113324_63710.333333333333334549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-114324_63710.333333333333334639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-113324_6370674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-113324_63710.333333333333334640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-113324_63710.333333333333334572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-113324_6370614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-113324_63710.333333333333334549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-114324_63710.333333333333334639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-113324_6370674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-113324_63710.333333333333334640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-113324_63710.333333333333334572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-113324_6370614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-113141_2220549.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-114141_2220639.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-113141_222135.33333333333334674.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-113141_2220640.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-113141_2220572.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-113141_2220614.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-113141_22210.333333333333334549.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-114141_22210.333333333333334639.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-113141_2220674.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-113141_22210.333333333333334640.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-113141_22210.333333333333334572.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-113141_2220614.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-113141_22210.333333333333334549.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-114141_22210.333333333333334639.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-113141_2220674.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-113141_22210.333333333333334640.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-113141_22210.333333333333334572.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-113141_2220614.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-11315_190549.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-11415_190639.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-11315_190640.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-11315_190572.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-11315_190614.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-11315_1910.333333333333334549.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-11415_1910.333333333333334639.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-11315_190674.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-11315_1910.333333333333334640.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-11315_1910.333333333333334572.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-11315_190614.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-11315_1910.333333333333334549.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-11415_1910.333333333333334639.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-11315_190674.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-11315_1910.333333333333334640.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-11315_1910.333333333333334572.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-11315_190614.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-113277_2960549.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-114277_2960639.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-113277_296135.33333333333334674.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-113277_2960640.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-113277_2960572.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-113277_2960614.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-113277_29610.333333333333334549.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-114277_29610.333333333333334639.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-113277_2960674.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-113277_29610.333333333333334640.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-113277_29610.333333333333334572.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-113277_2960614.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-113277_29610.333333333333334549.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-114277_29610.333333333333334639.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-113277_2960674.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-113277_29610.333333333333334640.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-113277_29610.333333333333334572.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-113277_2960614.0Zinc fingerCCHC-type


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Fusion Gene Sequence for SF1-CST6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000377390_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(transcript)=782nt_BP=369nt
ACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAG
GCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCT
CCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCC
GGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCA
CGCCGTTGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACTTCCGAGACACGCACATCA
TCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCCGCAAGACCAGGGTCACTG
GAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTGAGGTCCTTGTGGTTCCCT
GGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATTGGGTTTGGGGCCATGGTG

>In-frame_ENST00000377390_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(amino acids)=195AA_start in transcript=646_stop in transcript=59
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------
>In-frame_ENST00000377394_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(transcript)=799nt_BP=386nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACTT
CCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCCG
CAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTGA
GGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATTG

>In-frame_ENST00000377394_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(amino acids)=195AA_start in transcript=663_stop in transcript=76
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------
>In-frame_ENST00000227503_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(transcript)=799nt_BP=386nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACTT
CCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCCG
CAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTGA
GGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATTG

>In-frame_ENST00000227503_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(amino acids)=195AA_start in transcript=663_stop in transcript=76
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------
>In-frame_ENST00000334944_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(transcript)=838nt_BP=425nt
CGGAGCTCAGTTCACGCAGTAACAAATGAAGTGCGCGCTGCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTA
ACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCC
CAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGC
CGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGA
AAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCACGCCGTTGGTGCAGAAGGCGGCGCAGGCGGCCGT
GGCCAGCTACAACATGGGCAGCAACAGCATCTACTACTTCCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAA
GTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCCGCAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGGC
AGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTGAGGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTG
TGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATTGGGTTTGGGGCCATGGTGGAGGGCACTTCAGGTCCGTGGGCCGTATCTGTCA

>In-frame_ENST00000334944_ENST00000312134_TCGA-13-1489-01A_SF1_chr11_64545834_-_CST6_chr11_65779657_length(amino acids)=195AA_start in transcript=702_stop in transcript=115
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------
>In-frame_ENST00000377387_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545458_-_CST6_chr11_65779656_length(transcript)=897nt_BP=483nt
CCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAG
CGAACGCCACGCCGTTGGGTAAGCTGGGCCCCCCCGGGCTGCCCCCGCTCCCCGGGCCCAAAGGAGGCTTCGAGCCGGGCCCTCCGCCTG
CACCCGGGCCTGGGGCGGGGCTGCTGGCTCCCGGGCCGCCGCCGCCCCCGCCCGTGGGCTCGATGGGGGCCCTGACCGCGGCCTTCCCCT
TCGCGGCGCTGCCTCCGCCGCCTCCGCCGCCGCCCCCTCCGCCTCCCCAGCAGCCGCCGCCGCCTCCACCGCCACCGTCCCCCGGCGCCT
CGTACCCGCCGCCGCAGCCGCCCCCTCCGCCGCCGCTCTACCAGCGCGTGTCGCCGCCGCAGCCGCCGCCACCCCAGCCGCCGCGTAAGG
ACCAGCAGCCGGGCCCGGCCGGCGGCGGAGGAGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATC
TACTACTTCCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACA
GACTGCCGCAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGT
GACTTTGAGGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAA

>In-frame_ENST00000377387_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545458_-_CST6_chr11_65779656_length(amino acids)=254AA_start in transcript=761_stop in transcript=0
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHLLRRRPGPAAGPYAAAGVAAAAAATRAGRAAAEGAAAAAGTRRRGTVAVEAAAAAGEAEGAAAEAAEAAPRRGRPRSGPPSSPRAGA

--------------------------------------------------------------
>In-frame_ENST00000377390_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(transcript)=783nt_BP=369nt
ACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAG
GCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCT
CCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCC
GGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCA
CGCCGTTGGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACTTCCGAGACACGCACATC
ATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCCGCAAGACCAGGGTCACT
GGAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTGAGGTCCTTGTGGTTCCC
TGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATTGGGTTTGGGGCCATGGT

>In-frame_ENST00000377390_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(amino acids)=216AA_start in transcript=647_stop in transcript=0
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------
>In-frame_ENST00000377394_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(transcript)=800nt_BP=386nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACT
TCCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCC
GCAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTG
AGGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATT

>In-frame_ENST00000377394_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(amino acids)=221AA_start in transcript=664_stop in transcript=2
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------
>In-frame_ENST00000227503_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(transcript)=800nt_BP=386nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGGTGCAGAAGGCGGCGCAGGCGGCCGTGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACT
TCCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCAAGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCC
GCAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGGCAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTG
AGGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACTGTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATT

>In-frame_ENST00000227503_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(amino acids)=221AA_start in transcript=664_stop in transcript=2
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------
>In-frame_ENST00000334944_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(transcript)=839nt_BP=425nt
CGGAGCTCAGTTCACGCAGTAACAAATGAAGTGCGCGCTGCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTA
ACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCC
CAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGC
CGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGA
AAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCACGCCGTTGGGTGCAGAAGGCGGCGCAGGCGGCCG
TGGCCAGCTACAACATGGGCAGCAACAGCATCTACTACTTCCGAGACACGCACATCATCAAGGCGCAGAGCCAGCTGGTGGCCGGCATCA
AGTACTTCCTGACGATGGAGATGGGGAGCACAGACTGCCGCAAGACCAGGGTCACTGGAGACCACGTCGACCTCACCACTTGCCCCCTGG
CAGCAGGGGCGCAGCAGGAGAAGCTGCGCTGTGACTTTGAGGTCCTTGTGGTTCCCTGGCAGAACTCCTCTCAGCTCCTAAAGCACAACT
GTGTGCAGATGTGATAAGTCCCCGAGGGCGAAGGCCATTGGGTTTGGGGCCATGGTGGAGGGCACTTCAGGTCCGTGGGCCGTATCTGTC

>In-frame_ENST00000334944_ENST00000312134_TCGA-13-1489-02A_SF1_chr11_64545833_-_CST6_chr11_65779656_length(amino acids)=230AA_start in transcript=703_stop in transcript=11
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SF1-CST6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SF1-CST6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SF1-CST6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSF1C0025202melanoma1CTD_human
TgeneCST6C0006142Malignant neoplasm of breast1CTD_human
TgeneCST6C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneCST6C0025202melanoma1CTD_human
TgeneCST6C0033578Prostatic Neoplasms1CTD_human
TgeneCST6C0376358Malignant neoplasm of prostate1CTD_human
TgeneCST6C0678222Breast Carcinoma1CTD_human
TgeneCST6C1257931Mammary Neoplasms, Human1CTD_human
TgeneCST6C1458155Mammary Neoplasms1CTD_human
TgeneCST6C4704874Mammary Carcinoma, Human1CTD_human